product - a diversified global pharmaceutical company · 37 38 43 . 4 humco • +1 (855) 925-4736...

PRODUCTC ATA L O GC O M P O U N D I N G

www.Humco.com +1 (855) 925-4736

HUMCO GLOBAL HEADQUARTERS201 W. 5th St, Floor 12Austin, TX 78701

PHONE & FAX+1 (855) 925-4736 - toll free+1 (512) 474-7400+1 (512) 474-7414 - fax

[email protected]

ONLINE ORDERINGwww.Humco.com

PROFESSIONAL SERVICE HOURSMonday-Friday, 8:30 AM - 5:30 PM Central Standard Time

PHARMACEUTICAL RESOURCECENTER & CUSTOMER SERVICE

+1 (855) 925-4736 - toll free+1 (512) [email protected]• Formulation questions• Stability testing & BUD data• Penetration studies• Request a sample• Certificate of Analysis

REMIT PAYMENTS TO7400 Alumax DriveTexarkana, TX 75501

SHIPPING - FREEUPS Ground Service is free for DTP (Direct-to-Pharmacy) accounts on orders of more than $100 and weighing less than 200 pounds in the lower 48 states. For orders less than $100, shipping charges based on weight will apply.

Excludes hazardous materials, oversized (larger than 84”) items, drop shipped, and any items requiring special handling.

ALASKA & HAWAIIUS published rate

OUTSIDE THE U.S.Please call your International Representa-tive for current shipping charges

HAZARDOUS MATERIALSPer package fee of $25 in addition to air or ground shipping charge.

BACK ORDERSWe will notify you if any items are unavailable to ship. All back orders will be shipped free, UPS 3 day service, unless otherwise specified.

SDS & BUD STUDIESAvailable online at www.Humco.com

2 HUMCO • VERSION 1.0 • +1 (855) 925-4736 • WWW.HUMCO.COM

WWW.HUMCO.COM • +1 (855) 925-4736 • VERSION 1.0 • HUMCO 3

CONTENTSABOUT HUMCOHUMCO COMPOUNDINGPRODUCT LISTACTIVE PHARMACEUTICAL INGREDIENTSVALIDATED STABILITY STUDIESCREAMS & LOTIONSGEL BASES & OINTMENTSPRE-MIXED EXCIPIENT BASESORAL VEHICLESMISCELLANEOUS INGREDIENTS

4568

101233373843

4 HUMCO • +1 (855) 925-4736 • WWW.HUMCO.COM

Humco, founded in 1872, is a diversified global pharmaceutical company. Humco is focused on developing, manufacturing and commercializing innovative pharmaceuticals and high-quality over-the- counter (OTC) medicines for patients around the world.

With headquarters in Austin, TX, Humco serves over 45,000 pharmacies through its Pharmaceutical Segment and its Consumer OTC Products franchise. The Company is anchored by its lead-ing non-sterile compounding deliv-ery vehicles, including topical and transdermal creams, syrups and suspensions. Humco also serves consumers through its established and diverse Consumer OTC Prod-ucts business of over 160 items with product placement in all major drug, food, and mass-market retail chains, along with independent, locally owned pharmacies.

Humco’s leading team of professionals have strong exper-tise ranging from product develop-ment to commercialization in the Company’s state-of-the-art FDA registered, cGMP compliant facili-ties.

With a presence in approximately 20 countries, Humco is committed to working with pharmacists, physicians, health- care providers and patients to deliver innovative and meaningful treaments that help people around the world live longer, healthier lives.

ABOUT HUMCO

WWW.HUMCO.COM • +1 (855) 925-4736 • HUMCO 5

HUMCO COMPOUNDING

OUR APPROACH:

•We can be counted on

•We get the job done

•We take responsibility

•We find a better way

•We succeed as a team

Humco proudly manufactures and distributes a diversified line of phar-maceutical products. We focus on developing products that offer dynamic solutions and help to fulfill unmet pa-tient and pharmacist needs.

Humco has a vast portfolio ofpharmaceuticals thataid in imperativesolutions across several key therap-eutic categoriesincluding:

• Pain Management• Infectious Disease• Hormone Replacement Therapy• Wound Care• Dermatology and Aesthetics Humco has established a leading rep-utation for developing, manufacturing, and commercializing a diversified line of non-sterile topical and oralpharmaceutical compounding delivery vehicles. Our patented compounding products range from ready-to-use

topical creams and gels to oralsyrups and suspensions. Our prod-ucts are designed to provide an opti-mal delivery system for a variety offormulations based on the desired route of administration and therapeu-tic intent. Humco’s delivery vehicles are tailored to meet pharmacist’s non-sterile compounding needs while reducing the compounding preparation time and improving therapeutic outcome for patients.

In addition to our delivery vehicles, Humco offers an extensive selection of Active Pharmaceutical Ingredients (APIs) that are conveniently pack-aged in a variety of sizes to effectively accommodate the needs of pharma-cists, hospitals, and pharmaceutical companies.


TOPICAL BASES & VEHICLESCREAMS & LOTIONSAnhydrous Base™VERSATILE TOPICAL CREAM

Item No. Size Price 6013-01 1 lb/454 g $50.00

GENEDERM™ DERMATOLOGICAL TOPICAL CREAM

Item No. Size Price 6026-56 500 g $186.00

HRT Botanical™HORMONE THERAPY TOPICAL CREAM

Item No. Size Price 6001-01 1 lb/454 g $38.006001-79 10 lb/4500 g $240.00

HRT Heavy™HORMONE THERAPY TOPICAL CREAM

Item No. Size Price 6002-01 1 lb/454 g $38.006002-79 10 lb/4500 g $240.006002-81 40 lb/18200 g $660.00

Liposomal Heavy™VERSATILE TOPICAL CREAM


Liposomal Regular™VERSATILE TOPICAL CREAM


Multibase™ VERSATILE TOPICAL CREAM


PENcream™ VERSATILE TOPICAL CREAM


RECURA™ANTIFUNGAL TOPICAL CREAM

Item No. Size Price 6020-56 500 g $1000.006020-59 2500 g $5000.00

SALTSTABLE LO™ PAIN MANAGEMENT TOPICAL CREAM


SALTSTABLE LSADVANCED™PAIN MANAGEMENT TOPICAL CREAM

Item No. Size Price 6021-56 500 g $90.006021-57 4500 g $525.006021-58 18000 g $1890.00

GEL BASES & OINTMENTSLavare™WOUND WASH GEL


PLO20 Flowable™VERSATILE TOPICAL LIGHT CREAM

Item No. Size Price 0135-01 1 lb/454 g $65.00

PLO20 Non-Flowable™ VERSATILE TOPICAL CREAM


Universal Water Gel™VERSATILE TOPICAL GEL


PRE-MIXED EXCIPIENT BLENDSEmulsion Concentrate™VISCOSITY ENHANCER

Item No. Size Price 6016-94 4 oz $35.006016-98 8 oz $57.006016-28 1 gal $800.00

USP GUIDELINESIt is the responsibility of the pharmacists to follow USP Guidelines and state-specific rules on proper compounding procedures and techniques. Compounders should refer to USP Chapter <795> and <1075>, which relate to non-sterile compounding, to help define good compounding practice and provide general information on acceptable strength, quality and purity.

Sanare Advanced™ SCAR THERAPY BASE


Syrpalta (No Color)SYRUP VEHICLE

Item No. Size Price 3927-16 16 oz/473 ml $16.00

Versa Free™SYRUP VEHICLE

Item No. Size Price 0125-16 16 oz/473 ml $16.500125-28 1 gal/3.8 L $85.00

Versa Plus™SUSPENDING VEHICLE


Cherry Syrup™ SYRUP VEHICLE


Flavor Blend™SYRUP & SUSPENDING VEHICLE


Flavor Plus™SUSPENDING VEHICLE


Flavor Sweet-SF™SYRUP VEHICLE

Item No. Size Price 0094-16 16 oz/473ml $12.250094-28 1 gal/3.8 L $80.00

Flavor Sweet™SYRUP VEHICLE


Mouthwash-AF™ ALCOHOL FREE MOUTHWASH BASE


Mouthwash-GP™ GENERAL PURPOSE MOUTHWASH BASE


Mouthwash-OM™ MOUTHWASH BASE FOR ORAL MUCOSITIS


Raspberry SyrupSYRUP VEHICLE


Simple SyrupSYRUP VEHICLE

Item No. Size Price 2661-16 16 oz/473 ml $12.002661-28 1 gal/3.8 L $65.002661-75 5 gal/19 L $180.00

Sorbitol Solution70% USP SYRUP


Syrpalta (Red) SYRUP VEHICLE



Our compounding bases and vehicles are ready-made with wetting agents already incorporated into the base. Most formulations will not require any additional wetting or milling, greatly reducing the compounding preparation time.

ORAL VEHICLES

*Prices are current at time of printing (July 1, 2017); however, pricing and specifications are subject to change without notice. Please contact the Resource Center or visit the website for updated pricing.

BULK PRICING AVAILABLEContact us for pricing on bulk quantities

+1 (855) 925-4736

Amantadine Hydrochloride, USP


Amitriptyline Hydrochloride, USP


Baclofen, USP Item No. Size Price 8032-62 100 g $275.008032-43 1000 g $1150.00

Benzocaine, USP Item No. Size Price 8049-62 100 g $15.008049-43 1000 g $85.00

Bupivacaine Hydrochloride, USP


CyclobenzaprineHydrochloride, USP


DHEA (Micronized) (Prasterone)


Diclofenac, USP Item No. Size Price 8052-62 100 g $65.008052-43 1000 g $399.00

Doxycycline Hyclate, USP


Estradiol, USP(Micronized)


Estriol, USP(Micronized)


Estrone USP Item No. Size Price 8067-19 25 g $143.008067-62 100 g $328.00

ACTIVE PHARMACEUTICAL INGREDIENTS


Fluconazole, USP Item No. Size Price 8036-19 25 g $119.008036-62 100 g $305.00

Flurbiprofen, USP Item No. Size Price 8053-19 25 g $109.008053-62 100 g $225.008053-43 1000 g $790.00

Fluticasone Propionate, USP (Micronized)


Gabapentin, USP Item No. Size Price 8055-62 100 g $260.008055-43 1000 g $550.00

Ibuprofen, USP Item No. Size Price 8038-19 25 g $9.008038-62 100 g $14.008038-43 1000 g $65.00

Ketamine Hydrochloride, USP


Ketoprofen, USP Item No. Size Price 8056-62 100 g $55.008056-43 1000 g $385.00

Lidocaine Hydrochloride, USP


Methimazole, USPItem No. Size Price 8074-62 100 g $145.008074-43 1000 g $840.00

Miconazole, USP Item No. Size Price 8041-19 25 g $39.008041-62 100 g $120.00

Pentoxifylline, USP Item No. Size Price 8071-43 1000 g $389.00

Phenytoin Sodium, USP


Before Humco considers purchasing an Active Pharmaceutical Ingredient (API), we pre-qual-ify our suppliers to ensure that they manufacture the API under current Good Manufacturing Practices, as expected in ICH Q7A requirements.

Once the API is received, a statistical sample is taken and tested in our on-site laboratories. Through comprehensive and thorough testing, we ensure the identity of the API and that the potency meets the USP requirements and are comparable to the manufacturer’s Certificate of Analysis (CofA).

We use qualified and calibrated state-of-the-art analytical equipment under the Laboratory Controls delineated in 21 CFR 211. A few examples of these include:


API Standards & Testing

• Fourier Transform Infrared Spectro-photometer (FTIR)• Ultra Violet/Visible Light Spectro-photometer (UV/Vis)• Identification by Chemical Reac-tions

• Identification by Flame• High Pressure Liquid Chromatogra-phy (HPLC)• Gas Chromatograph (GC)• Thin Layer Chromatography (TLC)• Titrations

Humco is committed to adhering to the highest quality standards to ensure that our products are consistently valued as the best option for patients and pharmacists.

Prilocaine, USP Item No. Size Price 8030-43 1000 g $750.00

Progesterone, USP(Micronized)


Promethazine Hydrochloride, USP


Testosterone, USP (Micronized)


Tetracaine Hydrochloride, USP


Liothyronine, USP(T3)


Levothyroxine, USP(T4)


Thyroid, USP(Porcine)

8077-62 100gm $350.008077-43 1000gm $1950.00

Verapamil Hydrochloride, USP


Active Ingredient HRT Botanical

HRTHeavy

LiposomalHeavy

LiposomalRegular

Multi-base

PEN-cream

PLO20Non-Flowable

PLO20 Flowable

RECURA SaltStable LO

SaltStable LS Advanced

Amitriptyline HCl 90

Baclofen 90

Benzocaine 90

Bupivacaine HCl 90

Capsaicin 90

Clomipramine HCl 90 90

Cyclobenzaprine HCl 90 90

Dehydroepiandrosterone 90

Dexamethasone 90

Diclofenac 90

Diclofenac Na 90

Diltiazem 90 90

Diphenhydramine HCl 90

Estradiol 90 180

Estriol 120 180

Estrone 150 180

Fluconazole 180

Fluoxetine HCl 90 90

Flurbiprofen 90

Gabapentin 90 90 90 90 90 90

Haloperidol 90 90

Hydroquinone 90

Ibuprofen 90 60 90 90

Ketamine HCl 90

Ketoprofen 90 90 90 90

Lactic Acid 90

Lidocaine 90 90 90

Lidocaine HCl 90

Menthol 90

Methimazole 90 90 90 90

Methyl Salicylate 90

Metoclopramide 90

Metronidazole 90 90 90 90

Miconazole 180

Pentoxifylline 90

Phenytoin 90

Piroxicam 90 60 60


The Beyond-Use-Date study evaluates the potency and stability of a formula over a course of time, from 30 days to 180 days. Below is an alphabetical listing of the API’s studied for stability with correlating bases used for the compounded preparations. Please note, strength depends on percentage of API used. See appropriate product page for details.

VALIDATED STABILITY STUDIES


Active Ingredient Flavor Blend

Flavor Sweet/SF

Flavor Plus

Versa Free

Versa Plus

Acetazolamide 60 60

Allopurinol 60 60

Alprazolam 60 60

Amiodarone HCl 91 91

Amlodipine Besylate 91 91

Atenolol 60 60

Captopril 23 23 23

Clonidine HCl 60 60

Chloroquine HCl 60 60

Cisapride 60 60

Dapsone 91 91

Diltiazem HCl 60 60 90 90

Dipyridamole 60 60

Enalapril Maleate 60 60

Flecainide Acetate 60 60

Flucytosine HCl 60 60

Hydralazine HCl 63

Ketoconazole 60 60

Lactic Acid 60 60

Lamotrigine 91 91

Metolazone 60 60

Metoprolol Tartrate 60 60

Nifedipine 91 91

Omeprazole 90

Procainamide HCl 60 60

Pyrazinamide 60 60

Quinidine Sulfate 60 60

Rifampin 28 28

Sildenafil Citrate 91 91

Spironolactone 60 60

Tetracycline 90 28 28

Verapamil HCl 60 60

Prednisolone 90 90

Prednisone 90 90

Progesterone 180 180 180

Promethazine 90 90 90 90

Testosterone 180 180 180

Tetracaine HCl 90 90

Verapamil HCl 90

Active Ingredient HRT Botanical

HRTHeavy

LiposomalHeavy

LiposomalRegular

Multi-base

PEN-cream

PLO20Non-Flowable

PLO20 Flowable

RECURA SaltStable LO

SaltStable LS Advanced

Item No. NDC No. Size Price6013-01 00395-6013-01 1 lb $50.00

Humco’s Anhydrous Base™ is designed for low-load hydrophilic and high-load lipophilic actives that are unstable in water. Compatible with numerous drugs across a broad range of applications, Anhydrous Base™ is cosmetically elegant with an exceptional sensory evalua-tion profile over other anhydrous bases, providing a smooth, light, and silky feel.

ANHYDROUS BASE™ BENEFITS:• Contains absolutely no water• Non-greasy • Cosmetically elegant – smooth, light, silky feel• Preservative-free & petroleum-free• Easy to use – actives can be directly incorporated without wetting• 180-day BUD with all API’s based on USP 795• Fragrance-free & dye-free

VERSATILE TOPICAL CREAM


ANHYDROUS BASE™Wound

&Scar

Creams &

Lotions

ANHYDROUS BASE™ PROPERTIES

Specific Gravity 0.95

Color Light Beige

Transdermal Penetration + + +

API CompatibilityHydrophilic 10% & Lipophilic 20% Total API Load - 20%

Typical Applications• Dermatology • HRT • Pain Management • Sports Medicine • Veterinary Medicine • Wound Care

SAMPLE FORMULAS:

Mixing Tips• Mixing Speed - 1000 rpm for

2-5 minutes• If Dispensing in a Pump,

Airless Pump Dispensers are Recommended

Ingredients: Cyclomethicone, dimethicone, and silica and other proprietary ingredients

Glutathione 20% Topical

Glutathione (L) Reduced 20% Anhydrous Base qs 100% Recommended Penetration Enhancer: 50% Lecithin in Isopropyl Palmitate

Hydro/Lido/Nife 2.5/1.5/1% Topical

Hydrocortisone 2.5%Lidocaine HCl 1.5%Nifedipine 1%Anhydrous qs 100%


Creams &

LotionsGENEDERM™

GENEDERM™ provides a firming effect on the skin - tightening and smoothing fine lines and wrinkles. It is uniquely formulated with Sodium Polystyrene Sulfonate, a film forming polymer that creates a matrix and provides excellent binding to the skin, allowing the base to adapt to changes in facial expressions and movement without cracking or peeling. GENEDERM™ can be used to reduce the appearance of fine lines and wrinkles. GENEDERM™ BENEFITS:• Suitable for all skin types• Comfortable - Allows skin to breathe• Can be worn for 4-8 hours, including night-time application• Can be applied without API’s for wrinkle treatment• Visible results after first application

DERMATOLOGICAL BASE FOR WRINKLES

Item No. NDC No. Size Price6026-56 00395-6026-56 500 g $186.00

GENEDERM™ PROPERTIES

pH 5.0 - 6.0

Viscosity 50,000 - 100,000 cps

Physical Format Light Cream

Color Opaque, Off-White


Typical Applications • Dermatology • Wrinkles

Anti Wrinkle:Alpha-Lipoic Acid 5%Ascorbyl Palmitate 2%Estriol Micro Powder 0.3%Niacinamide 2%Tretinoin 0.025%Propylene Glycol 10%GENEDERM qs 100%

SAMPLE FORMULA:

Common Actives in Wrinkle Care:

Vitamin E – 200IU/g Antioxidant to reduce the signs of aging and photo-aging

Vitamin C – 2-10% (as Ascorbyl Palmitate) Antioxidant to reduce the signs of aging

Niacinamide – 2% Stabilizing effect on epidermal barrier function, seen as the reduction in trans-epidermal water loss

Estradiol – 0.01% and Estriol 0.3% After treatment for 6 months, elasticity and firmness of the skin had markedly improved; wrinkle depth and pore sized had decreased by 61-100%; skin moisture had increased and wrinkle depth decreased significantly

Alpha-Lipoic Acid – 5% Twelve weeks treatment with a cream improves clinical characteristics related to photo-aging of facial skin


GENEDERM™CLINICAL STUDY

Clinical Study

STUDYEvaluation of Key Parameters on Outer Parts of 30 Panelist's Eyes, In Vivo, Using Image Analysis In one of the most innovative research projects ever undertaken inmedical aesthetics, ‘The Consumer Product Testing Company' captures the PRIMOS and VISIA image analysis, and opinions on wrinkle length, number, and area from 30 female subjects, ages 35 to 65, with mild to moderate crow's feet (coarse wrinkles) in the outer canthus eye area. The relative skin surface was analyzed as a composite and as a single point in any plane thereby making it possible to examine and compare several cutaneous parameters. The outer parts of the eyes of thirty panelists were used to evaluate several key parameters over eight weeks.

RESULTS'The Consumer Product Testing Company' key findings:

• For women seeking aesthetic treatment, opinions found (89%) positive response for “softened line/wrinkles around eyes, (89%) positive response for “made skin feel firmer/tighter”, and (100%) positive response for “easy to use as daily skin care regimen”.

• PRIMOS image analysis found (71%) of women with wrinkle length decrease.

• VISIA image analysis found (82%) of women with wrinkle number decrease and (79%) of women with wrinkle area decrease.

"Product is non-

irritating and

reduces visibility of

fine lines...

a small amount

goes a long way…

easy to use…

skin feels soft,

smooth, refreshed

and firm…it is not

greasy and has

pleasant smell…it

felt high quality.”

Parameter Genederm®

Roughness 14% DecreaseResidual Length 9% DecreaseAverage Amplitude 10% Decrease Primary Wrinkle 9% DecreaseNumber of Peaks 10% Reduction


GENEDERM™ Dermatological Wrinkle Basehas been proven to reduce or decrease five key parame-ters in relation to wrinkle reduction.

View Full Study at www.Humco.com

"The evaluation of parameters indicates that the use of Genederm™ produced smoothing and restructuring of the skin’s surface after seven days of product application." - Advanced Scientific Imaging Consulting, leading analytical laboratory

Item No. NDC No. Size Price6001-01 00395-6001-01 1 lb $38.00 6001-79 00395-6001-79 10 lb $240.00

HRT Botanical™ is an oil-in-water, light cream, certified hypoaller-genic base, with all natural ingredients and antioxidants. It has a lotion consistency and provides sustained skin penetration. Ideal for lipophilic APIs used in hormone replacement therapy (HRT).

HRT BOTANICAL™ BENEFITS:• Sustained skin penetration and absorption• Paraben-free & fragrance-free• Natural ingredients & natural preservatives• Added antioxidants, botanicals, and herbal extracts• Certified hypoallergenic• Cosmetically elegant• Ideal for vaginal preparations

CERTIFIED HYPOALLERGENIC HRT BASE

HRT BOTANICAL™


Wound &

Scar

Creams &

Lotions

HRT BOTANICAL™ PROPERTIES

pH 6.5


Viscosity 60,000 cps

Physical Format Light Cream

Color Light Beige

Transdermal Penetration + +

API Compatibility Lipophilic - 20%

Typical Applications • Hormone Replacement

Beyond-Use-Date (BUD)

ACTIVE INGREDIENT BUD

Estradiol – 1% 90 Days

Estriol – 1% 120 Days

Estrone – 0.5% 150 Days

Prednisolone 5% 90 Days

Progesterone – 20% 180 Days

Testosterone – 5% 180 Days

Ingredients: Aloe Barbadensis, Cetyl Alcohol, Ethylhexyl-glycerin, Evening Primrose Oil, Glycerin, Glyceryl Stearate, Grape Seed Oil, Hydroxylated Soybean Lecithin, Magnesium Aluminum Silicate, Oleic Acid, Olive Oil, PEG 100 Stearate, Phenoxyethanol, Purified Water, Stearic Acid, Trolamine NF, Vitamin E Acetate, Wheat Germ Oil, Xanthan Gum


Creams &

LotionsHRT HEAVY™

HRT Heavy™ is a heavier cream base than HRT Botanical™; it allows for deep skin penetration and absorption. It is specifically designed for male and female hormone replacement therapy (HRT) and has a moderate to high API carrying capacity. HRT HEAVY™ BENEFITS:• Sustained skin penetration and absorption• Paraben-free• Natural ingredients• Cosmetically elegant• Ideal for intra-vaginal preparations• Stability/potency of 180 days for all hormone APIs

HRT BASE WITH 180 DAY BUD

Item No. NDC No. Size Price6002-01 00395-6002-01 1 lb $38.00 6002-79 00395-6002-79 10 lb $240.00 6002-81 00395-6002-81 40 lb $660.00

HRT HEAVY™ PROPERTIES

pH 7.5



Physical Format Cream

Color White


API Compatibility Lipophilic - up to 40%

Typical Applications • Hormone Replacement



Estradiol – 1% 180 Days

Estriol – 1% 180 Days

Estrone – 0.5% 180 Days



Ingredients: C12-15 Alkyl Benzoate, Caprylic/Capic Triglycer-ide, Cetyl Alcohol, Ethylhexylglycerin, Glycerin USP, Glyceryl Stearate, Hydroxyethyl Acrylate/Sodium, Acryloydimethyl Taurate Coplymer, Oleic Acid, Olive Oil, Peg-100 Stearate, Phenoxyethanol, Polymethylsiloxane, Purified Water, Stearic Acid, Trolamine, and Vitamin E Acetate.


Transdermal Study PROGESTERONE

TRANSDERMAL STUDYStudyEvaluation of the Percutaneous Absorption of Progesterone, In Vitro, Using the Epiderm Skin ModelThe progesterone study evaluated the percutaneous ab-sorption pharmacokinetics of progesterone in the following Humco bases: HRT Botanical™, HRT Heavy™, Anhydrous Base™ and PENcream™. Absorption was measured in hu-man epidermal cultures, in vitro, using the finite dose tech-nique and Franz Diffusion Cells.

Formulas were tested on standardized sections for the per-cutaneous absorption of progesterone over a 12-hour dose period. At pre-selected times after dose application, the dermal receptor solution was completely removed and re-placed with fresh receptor solutions; an aliquot was saved for subsequent analysis. Samples were analyzed for proges-terone content by High Performance Liquid Chromatography (HPLC).

The in vitro human Epiderm skin model is a proven tool, valu-able for the study of percutaneous absorption and determina-tion of pharmacokinetics of topically applied drugs. The mod-el uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a tem-perature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer skin surface, and drug absorption is measured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption, can be accurately determined in this model.

Transdermal Drug Absorption:

• Avoids hepatic first pass effect, reducing adverse reactions to certain drugs

• Reduces minor gastrointestinal tract irritation and systemic toxicity

• Helps avoid possible drug interactions with food and intestinal flora

• Can be applied to different parts of the body (site rotation)

Humco’s PENcream™,

Anhydrous Base™,

HRT Heavy™, and

HRT Botanical™

are Validated Transdermal

Vehicles


PENcream™, Anhydrous Base™, HRT Botanical™, and HRT Heavy™have been proven to transport Progesterone into and through human skin, performing more effec-tively than our competitor's base.

5% PROGESTERONE

Transdermal Study

ResultsThe data did indicate that progesterone penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration to a peak flux occurring at approximately 12 hours after dose application. HRT Botanical™, HRT Heavy™, Anhydrous Base™, and PENcream™ delivered more progesterone than our competitor's base.

The total percent of applied dose that penetrated past the stratum corneum with our competitor’s base is 20% less than Humco’s HRT Botanical™, HRT Heavy™, Anhydrous Base™, and PENcream™.

Flux

(ug/

cm2/

hr)

Time

Progesterone Flux VS Time

0.00

0.05

0.10

0.15

0.20

0.25

0.30 Competitor’s Base

HRT Botanical

HRT Heavy

Anhydrous Base

PENCream

1284

% Progesterone Permeation Through the Stratum Corneum

% P

erm

eatio

n

Progesterone

Com

petit

or’s

Base

HRT

Bot

anic

al™

HRT

Hea

vy™

Anh

ydro

us B

ase™

PEN

Crea

m ™

Competitor’s BaseHRT BotanicalHRT Heavy

Humco's Anhydrous BasePENCream

0.40

0.20

0.00

1.00

0.80

0.60

1.60

1.40

1.20



LIPOSOMAL HEAVY™

Liposomal Heavy™ is formulated with additional emulsifiers to allow for higher API loads and solvent concentrations to be incorporated. Added emollients provide excellent moisturization—an ideal choice for dry and/or dehydrated skin. LIPOSOMAL HEAVY™ BENEFITS:• Cosmetically elegant – excellent moisturizing effect • Faster absorption & deeper penetration than HRT bases• API compatibility – virtually all actives• Natural preservatives• Water & oil-soluble• Ideal for cosmetic facial applications• Paraben-free

MOISTURIZING TRANSDERMAL LIPOSOMAL BASE

Item No. NDC No. Size Price6004-01 00395-6004-01 1 lb $50.00 6004-79 00395-6004-79 10 lb $365.006004-81 00395-6004-81 40 lb $1310.00

Creams &

Lotions

LIPOSOMAL HEAVY™ PROPERTIES

pH 6.0



Format Heavy Cream

Color White

Transdermal Penetration + + + +

API CompatibilityHydrophilic – 10%Lipophilic – 10%Total API Load – 20%

Typical Applications• Dermatology• Pain Management• Sports Medicine

Recommended Use

• Higher API Loads• Dry/Dehydrated Skin• Chemical Peels• Pigmentation Treatments

Ingredients: Caprylic/Capric triglycerides, Cetearyl Alcohol, Ceteareth-20, Cetyl Esters, Wax, Dimethicone 350 NF, Ethyl Alcohol, Ethylhexylglycerin, Glyceryl Stearate, Hydroxyethyl acrylate, Hydroxypropyl starch phospate, Lecithin, Octyldo-decanol, PEG-100 stearate, Phenoxyethanol, Poloxamer 407, Polyoxyethylene (2) stearyl ether, Polyoxyethylene (21) stearyl ether, Polysorbate 60, Propylene Glycol, Purified Bentonite, Purified Water, Sodium acryloyldimethyl taurate copolymer, Sorbitol, Squalene and Stearyl alcohol


ACTIVE INGREDIENT BUDDexamethasone – 1.5% 90 DaysDiclofenac – 4% 90 DaysDiltiazem – 2% 90 DaysGabapentin – 6% 90 DaysHaloperidol – 0.1% 90 DaysHydroquinone – 5% 90 DaysPiroxicam – 0.5% 90 DaysPromethazine – 5% 90 Days


Creams &

LotionsLIPOSOMAL REGULAR™

Liposomal Regular™ is a cosmetically elegant, liposomal transdermal base with excellent skin penetration and moisturizing capabilities. It is formulated to incorporate lipophilic and hydrophilic actives and penetrate deeper and faster than HRT bases.

LIPOSOMAL HEAVY™ BENEFITS:• Cosmetically elegant – excellent moisturizing effect • Faster absorption & deeper penetration than HRT bases• API compatibility – virtually all actives• Natural preservatives• Water & oil-soluble• Ideal for cosmetic facial applications• Paraben-free

TRANSDERMAL LIPOSOMAL BASE



ACTIVE INGREDIENT BUDDehydroepiandrosterone – 1.23% 90 DaysEstradiol – 0.5% 60 DaysGabapentin – 12.28% 90 DaysMethimazole – 5% 90 DaysProgesterone – 4.8% 90 Days

Mixing Tip• Recommended to Reduce Oxidation:

Sodium Bisulfite - 0.5%

Ingredients: Alcohol USP, Caprylic/Capric triglycerides, Ceteareth 20, Cetearyl alcohol, Cetyl alcohol, Ethylhexylglycerin, Glycerin USP, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Isopropyl Palmitate, Magnesium, Aluminum silicate, Oleic acid,Phenoxyethanol, Polymethylsiloxane, Purified water, Soy lecithin, Stearyl alcohol and Xanthan gum

LIPOSOMAL REGULAR™ PROPERTIES

pH 7.5



Format Light Cream

Color Off-White



Typical Applications

• Dermatology• Pain Management• Hormone Therapy• Veterinary Medicine

Recommended Use• Lower API Loads• Cosmetic Preparations


MULTIBASE™

A versatile, oil-in-water natural vanishing cream that uses oleosomic emulsifiers and penetration enhancers. It is an oil-free moisturizing base that provides natural skin penetration. MultiBase™ is designed for both hydrophilic and lipophilic actives and exhibits superior stabil-ity in the presence of low-pH, high-pH, and high-alcohol compounds, allowing for flexible compounding and formulation options.

MULTIBASE™ BENEFITS:• Mineral oil-free, gluten-free, and propylene glycol-free• Noncomedogenic• Enhanced drug absorption & penetration• Ideal for vaginal preparations• Stable over a broad range pH• API compatibility – hydrophilic & lipophilic• Natural ingredients – moisturizers derived from berries, grapes, plums, and pears & emulsifiers derived from vegetable fatty acids& palm oil; thickening agents derived from coconut oil

HIGHLY VERSATILE OIL-IN-WATER CREAM BASE

Item No. NDC No. Size Price6015-01 00395-6015-01 1lb $45.00 6015-79 00395-6015-79 10 lb $380.006015-81 00395-6015-81 40 lb $1400.00

Creams &

Lotions

MULTIBASE™ PROPERTIES

pH 7.0



Physical Format Heavy Cream

Color White

Transdermal Penetration + +


pH Compatibility 3.0 - 11.0

Salt Tolerance Salt Forms - 10%

Typical Applications

• Hormone Replacement • Dermatology • Pain Management • Sports Medicine

Beyond-Use-Date (BUD)ACTIVE INGREDIENT BUD

Capsaicin – 1.2% 90 Days

Lactic Acid – 8.5% 90 Days

Lidocaine – 8% 90 Days

Menthol – 8% 90 Days

Methyl Salicylate – 20% 90 Days

Metronidazole – 8% 90 Days

Phenytoin – 8% 90 Days



HRT Cream:Progesterone 20%Glycerin 10%Multibase qs 100%

Analgesic Cream:Capsicum Oleoresin 0.6% Methyl Salicylate 10%Menthol 4%Multibase qs 100%

SAMPLE FORMULAS:

Ingredients: Purified Water, Ethylhexyl Stearate, Cetearyl Alcohol, Polysorbate-60, Aloe Leaf Juice, Vitamin E, EDTA, Sorbitol, Cyclomethicone and Isothiazolinone


Creams &

LotionsPENCREAM™

PENcream™ is an elegant oil-in-water vanishing cream formulated for enhanced transdermal penetration and absorption. This elegant alternative to PLO, with added emollients, provides a better rub-in and longer-lasting moisturizing effects without irritation. PENcream™ is compatible with a diverse range of hydrophilic and lipophilic actives, has a high API load capacity, and is ideal for hybrid formulations.

PENCREAM™ BENEFITS:• Free of BHT, EDTA, parabens, and urea• Enhanced penetration capability – efficacious API absorption• Hydrophilic & lipophilic compatibility – high loads• Natural ingredients – less irritation than PLO• Cosmetically elegant – lasting moisturizing effect• Applies easily – no sticky residue

TRANSDERMAL OIL-IN-WATER VANISHING BASE


PENCREAM™ PROPERTIES

pH 7.0




Color White


API CompatibilityHydrophilic & Lipophilic - Total API Load - 30%

Typical Applications• Pain Management • Veterinary Medicine


Clomipramine HCl– 7.5% 90 Days

Fluoxetine HCl– 7.5% 90 Days

Gabapentin – 6% 90 Days

Ibuprofen – 10% 90 Days

Ketoprofen - 10% 90 Days


Methimazole – 7.5% 90 Days

Metoclopramide – 2% 90 Days


Promethazine – 5% 90 Days

Tetracaine HCl– 2% 90 Days

Mixing Tips• Water Soluble Powders:

If needed, may levigate with Alcohol, Dimethyl Sulfoxide (DMSO), Glycerin, Polyethylene Glycol (PEG) 300 or 400, Propylene Glycol, or Purified Water

• Oil-Soluble Powders Can be Directly Incorpo-rated

Ingredients: Purified water, isopropyl palmitate, caprylic/capric triglyceride, propylene glycol, ceteareth 20, cetearyl alcohol, glyceryl stearate, PEG-100 stearate, dimethicone,octyldodecanol, lecithin, ethylhexylglycerin, andphenoxyethanol

SAMPLE FORMULAS:

Veterinary:

Methimazole 7.5%PENcream qs 100%

Pain Management Cream 1:

Amitriptyline 2%Diclofenac 1%Gabapentin 5%PENcream qs 100%


RECURA™Creams

&Lotions

RECURA™ topical cream is an innovative compounding delivery vehicle created for creams compounded to treat conditions such as onychomycosis. Utilizing penetration enhancers, RECURA™ pro-vides good penetration into toenails, fingernails, and skin, works well with a variety of antifungal agents, and compounds easily. It has been intensively studied, patented, and peer-reviewed in order to validate the compatibility of the cream with a number of active ingredients.

RECURA™ BENEFITS:• Penetration Ability - contains penetration enhancers and natural oils to facilitate active drug absorption• Drug Compatibility - both oil and water soluble powders can be levigated with alcohol• Compound Diversity - contains penetrating agents for better nail absorption, natural oils for better skin absorption, and is alcohol- dispersible for viscosity adjustment

TOPICAL BASE FOR ANTIFUNGAL ACTIVES

Item No. NDC No. Size Price6020-56 00395-6020-56 500 g $1000.006020-59 00395-6020-59 2500 g $5000.00

RECURA™ PROPERTIES

pH 7.0 - 9.0

Physical Format Viscous Cream

Color Opaque, Light Lavender

Typical ApplicationsFungal treatment on toenails, fingernails, and skin

Nail Cream 1:Miconazole 3 gRECURA 27 g

Nail Cream 2:Fluconazole 3 g RECURA 27 g

Skin Cream:Clotrimazole 0.6 g Ibuprofen 0.6 gRECURA 28.8 g

SAMPLE FORMULAS:

RECURA™ Peer

Reviewed Studies:

• IJPC, Jan/Feb

2016, Pgs 71-80

• IJPC, Mar/Apr 2017,

Pgs 154-159


Published Studies – Beyond-Use-Date (BUD)


Fluconazole – 10% 180 Days

Miconazole – 10% 180 Days

Creams &

Lotions

Your Compounding Vehicle to help you

TOPICAL COMPOUNDING CREAM

ABOUT RECURA• RECURA can be formulated to hold and help in the delivery of various antifungal active ingredients

• In Vitro testing in a novel nail model suggests the potential utility of RECURA topical cream to enhance delivery of antifungal actives across the nail

• Peer reviewed study1 in in vitro nail models comparing drug absorption with RECURA vs. marketed prescription solutions

• RECURA is for topical use only and is not for oral, ophthalmic, or intravaginal use

1 Turner R et al., A Novel Vehicle for Enhanced Drug Delivery Across the Human Nail for the Treatment of Onychomycosis, INTL. J. PHARM. COMPOUNDING 2016;20(1):71-80

Manufactured By:

Humco | 512 E 11th St, Ste 201, Austin, Texas 78701 - USATel. (512)474-7400 | Fax (512)474-7414

[email protected] | www.Humco.com

RECURA topical cream is an innovative compounding delivery vehicle created for creams compounded to treat conditions such as onychomycosis.



SALTSTABLE LO™Creams

&Lotions

SaltStable LO™ is a ready-to-use transdermal cream base providing an elegant alternative to traditional PLOs. It is uniquely designed with a long shelf life and is temperature stable. It will not separate in the presence of high levels of ionic substances or when refrigerated. Added emulsifiers and hydrocolloids provide a chemical penetration enhancer (CPE) value superior to a PLO. SaltStable LO™ is cosmeti-cally elegant and compatible with both hydrophilic and lipophilic APIs allowing for compounding flexibility.

SALTSTABLE LO™ BENEFITS:• Efficacious active drug absorption• In vitro transdermal penetration & API compatibility• Temperature stable & two-year shelf stable• Hydrophilic compatibility – high levels of ionic powders can be directly incorporated • Lipophilic compatibility – moderate levels of oil-soluble powders can be levigated with glycerin, propylene glycol, polyethylene glycol (PEG) 300 or 400, or alcohol• Cosmetically elegant – not tacky or sticky• Natural ingredients – resulting in less irritation

READY-TO-USE TRANSDERMAL PAIN BASE


SALTSTABLE LO™ PROPERTIES

pH 7.0




Color Light Yellow


API CompatibilityHydrophilic 35% & Lipophilic 10% Total API Load 35%

Typical Applications• Pain Management • Veterinary Medicine • Sports Medicine


Benzocaine – 20% 90 Days

Diphenhydramine HCl – 10% 90 Days

Fluoxetine HCl – 5% 90 Days


Ketoprofen – 10% 90 Days


Methimazole – 5% 90 Days


Promethazine – 5% 90 Days

Tetracaine HCl – 4% 90 Days

Ingredients: Isopropyl palmitate, lecithin and proprietary ingredients

SAMPLE FORMULAS:

BLT:

Benzocaine 20%Lidocaine 6%Tetracaine 4%SaltStable LO qs 100%

Lorazepam Formula:

Lorazepam 0.5%SaltStable LO qs 100%

Pain Management Cream:

Baclofen 2%Diclofenac 3%Gabapentin 3%Citric Acid 2%Ethoxy Diglycol 8%Salt Stable LO qs 100%


Creams &

LotionsSALTSTABLE LS ADVANCED™

SaltStable LS Advanced™ is an extension and enhancement of SaltStable LO™. SaltStable LS Advanced™ is a scientifically advanced, extremely durable, robust and versatile transdermal cream base formulated with a silogel that provides a smooth, silky dry feel. SSLS Advanced™ is designed for all actives and is non-specific to salt; it also exhibits superior API carrying capacity (high loads) of multiple actives in one formulation. SaltStable LS Advanced™ demonstrates excellent stability without the need to add emulsifiers.

SALTSTABLE LS ADVANCED™ BENEFITS:• Increased stability with a high percent of APIs & multiple actives• Validated in vitro transdermal vehicle up to 8 APIs in one formulation • Less sticky & less tacky because of silogel (silicone-based organogel)• Off-white, cosmetically elegant cream• API compatibility – compatible with all actives, non-specific to salt• Time saving – ready-to-use base, no need for wetting or adding thickening agents • Ideal for formulations with multiple actives & high API loads

READY-TO-USE TRANSDERMAL PAIN BASE

Item No. NDC No. Size Price6021-56 00395-6021-56 500 g $90.00 6021-57 00395-6021-57 4500 g $525.00 6021-58 00395-6021-58 18000 g $1890.00

SALTSTABLE LS ADVANCED™ PROPERTIES

pH 7.1 - 7.5


Viscosity 1,200,000 cps


Color Off White



Typical Applications• Pain Management • Veterinary Medicine • Sports Medicine


Baclofen – 2% 90 Days

Bupivacaine HCL – 1% 90 Days

Diclofenac Na – 5% 90 Days

Flurbiprofen – 10% 90 Days


Ibuprofen – 3% 90 Days

Ketamine HCl – 10% 90 Days

Ketoprofen – 20% 90 Days

Lidocaine HCl – 5% 90 Days

Pentoxyfylline – 3% 90 Days

Verapamil HCl– 10% 90 Days

Baclofen 2%Bupivacaine 1%Diclofenac 5%Gabapentin 6%Ibuprofen 3%Ketamine HCl 10%Pentoxifylline 3%SSLS Advanced qs 100%

Baclofen 2%Clonidine 0.2%Gabapentin 10%Ketamine 5%SSLS Advanced qs 100%

Diclofenac 5%Ibuprofen 3%Pentoxifylline 3%Verapamil 10%SSLS Advanced qs 100%

Baclofen 2%Flurbiprofen 10%Lidocaine HCl 5%Pentoxifylline 3%SSLS Advanced qs 100%

SAMPLE FORMULAS (90 DAYS):


Transdermal Study

STUDYEvaluation of the Percutaneous Absorption of Pentoxifylline + Ketamine HCl + Ibuprofen + Cyclobenzaprine HCl + Diclofenac Na + Baclofen + Bupivacaine HCl + Gabapentin, In SaltStable LS Advanced™, Into Human Skin, In Vitro, Using the Franz Skin Finite Dose Model

Using Humco’s SaltStable LS Advanced™, the study was designed to evaluate the percutaneous absorption pharmacokinetics of pent-oxifylline, ketamine HCl, ibuprofen, cyclobenzaprine HCl, diclofenac Na, baclofen, bupivacaine HCl and gabapentin in a single formula-tion using Humco’s SaltStable LS Advanced™ base. Absorption was measured in human epidermal cultures, in vitro, using the finite dose technique and Franz Diffusion Cells. The eight drugs were selected due to their frequent use in compounding topical pain formulations along with compoundingmultiple actives in one formulation. The formula was tested on standardized sections with Humco’s SaltStable LS Advanced™ transdermal compounding base, for the percutaneous absorption of the formula over a 48-hour dose period. At pre-selected times after dose application, the dermal receptor solution was removed in its entirety, replaced with fresh receptor solution, and an aliquot saved for subsequent analysis. High Performance Liquid Chromatography (HPLC) analyzed the samples for pentoxifylline, ketamine HCl, ibuprofen, cyclobenzaprine HCl, diclofenac Na, baclofen, bupivacaine HCl and gabapentin content.

The in vitro human Epiderm skin model has proven to be a valuable tool for the study of percutaneous absorption and the determination of the pharmacokinetics of topically applied drugs. The model uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a temperature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer surface of the skin and drug absorption is mea-sured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption can be accurately determined in this model.

SALTSTABLE LS ADVANCED™TRANSDERMAL STUDY

RESULTS Humco’s SaltStable LS Advanced™ compounding base is a proven trans-dermal delivery vehicle able to deliver multiple drugs beyond the stratum corneum, simultaneously into and through the human skin after a single dose. The data indicates that Humco’s SaltStable LS Advanced™ delivered pentoxifylline, ketamine HCl, ibuprofen, cycloben-zaprine HCl, diclofenac Na, baclofen, bupivacaine HCl, and gabapentin simultaneously (and intact) into and through human epidermal cultures, in vitro, from the test formulation provided. The absorption profiles indicate pentoxifylline, ketamine HCl, ibuprofen, diclofenac Na, and bupivacaine HCl had a steady penetration occurring for 32 hours after dose application. And cyclobenzaprine HCl, baclofen and gabapentin had a steady penetration occurring for 48 hours after dose application.


Creams &

Lotions

TESTED FORMULA

Baclofen.......................2%Bupivacaine ....................1% Cyclobenzaprine HCl.2% Diclofenac Na..............5% Gabapentin..................6% Ibuprofen.....................3% Ketamine HCl............10% Pentoxifylline...............3%SaltStable LS Advanced.....qs 100%

Breakthrough Study: SaltStable LS Advanced™has been proven to deliver eight drugs simultaneously through human skin in-vitro.

Flux

(ug/

cm2/

hr)

Time

Baclofen Flux VS Time

0.000

0.005

0.010

0.015

0.020

0.025

0.030SaltStable LS

ActiveMax

48322412842

Flux

(ug/

cm2/

hr)

Time

Bupivacaine Flux VS Time

0.00

0.05

0.10

0.15SaltStable LS

ActiveMax

483224128420

Flux

(ug/

cm2/

hr)

Time

Cyclobenzaprine Flux VS Time

Flux

(ug/

cm2/

hr)

Time

Diclofenac Flux VS Time

Flux

(ug/

cm2/

hr)

Time

Gabapentin Flux VS Time

Flux

(ug/

cm2/

hr)

Time

Ibuprofen Flux VS Time

Flux

(ug/

cm2/

hr)

Time

Ketamine Flux VS Time

Flux

(ug/

cm2/

hr)

Time

Pentoxifylline Flux VS Time

0.00

0.05

0.10

0.15

0.20

0.25

0.30

0.35SaltStable LS

ActiveMax

483224128420 0.00

0.20

0.40

0.60

0.80

1.00

4832241284200.000

0.020

0.040

0.060

0.080SaltStable LS

ActiveMax

483224128420

0.0

1.0

2.0

3.0

4.0SaltStable LS

ActiveMax

4832241284200.0

1.0

2.0

3.0

4.0SaltStable LS

ActiveMax

4832241284200.0

2.0

4.0

6.0SaltStable LS

ActiveMax

483224128420

STUDYEvaluation of the Percutaneous Absorption of Flurbiprofen + Lidocaine

The study evaluated the percutaneous absorption pharmacokinetics of Humco’s Sanare Advanced™ Scar Base. Absorption was measured in human epidermal cultures, in vitro, using the finite dose technique and Franz Diffusion Cells.

The formula was tested on standardized sections with two different transdermal compounding bases. At pre-selected times after dose application, the dermal receptor solution was completely removed and replaced with fresh receptor solution; and an aliquot was saved for subsequent analysis. Samples were analyzed for flurbiprofen and lidocaine content by High Performance Liquid Chromatography (HPLC).

The in vitro human Epiderm skin model is a proven tool, valuable for the study of percutaneous absorption and determi-nation of pharmacokinetics of topically applied drugs. The model uses human epidermal skin mounted in specially designed diffusion cells that allow the skin to be maintained at a temperature and humidity that match typical in vitro conditions. A finite dose of formulation is applied to the outer skin surface, and drug absorption is measured by monitoring the rate of appearance in the receptor solution bathing the inner surface of the skin. Data defining total absorption, as well as rate of absorption, can be accurately determined in this model.

Transdermal Study SANARE ADVANCED™-

TRANSDERMAL STUDY


TESTED FORMULA

Flurbiprofen ...............................10%Lidocaine ......................................5%Sanare Advanced™...........qs 100%

Sanare

Advanced™

out-performs

Competitor’s

Base

by 23-28%


- -

SANARE ADVANCED™ Scar Therapy Base


0

5

10

15

20

25

30

35

40

45Sanare Advanced

Competitor's Base

483224128420

Flurbiprofen Flux VS Time

10% FLURBIPROFEN

Transdermal Study

5% LIDOCAINE

Transdermal Study

has been proven to transport multiple drugs into and through human skin, performing significantly more effectively than our competitor’s base.

Lidocaine Flux VS Time

0

2

4

6

8

10Sanare Advanced

Competitor's Base

483224128420

RESULTSThe data did indicate that flurbiprofen penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration for 48 hours after dose application. Sanare Advanced™ performed significantly better than our competitor's base at delivering flurbiprofen through human skin.

The data also indicated that lidocaine penetrated into and through human epidermal cultures, in vitro, from the test formulations provided. The absorption profiles indicate a steady penetration for 48 hours after dose application. Humco’s Sanare Advanced™ performed significantly better than our competitor’s base at delivering lidocaine through human skin.

The total percent of applied dose that penetrated past the stratum corneum with our com-petitor’s base is 23% less with flurbiprofen and 28% less with lidocaine than Humco’s Sanare Advanced™.

Flux

(ug/

cm2/

hr)

Time

Flux

(ug/

cm2/

hr)

Time

- -

Common Actives in Scar Care:

Pentoxifylline – 0.1 – 0.5% Decreases collagen production, increases activity of collagenase in dermis, inhibits fibroblast hyperactivity

Betamethasone – 0.1% Steroid and anti-inflammatory

Dimethyl Sulfone – 2% Anti-inflammatory

EGCg – 0.1 – 0.5% – Antioxidant

Caffeine – 0.1 – 1% Induces differentiation and proliferation in epidermal keratino-cytes

Collagenase – 350 u/g Reduces collagen production

Hyaluronidase – 250 u/g Breaks down collagen

Tranilast – 1 – 10% Antioxidant, decreases redness and swelling, inhibits collagen synthesis


Creams &

Lotions

TOPICAL SILICONE BASE FOR SCAR THERAPY & OTHER CONDITIONS

SANARE ADVANCED™-

Sanare Advanced™ is an elegant, topical anhydrous silicone gel designed for scar therapy treatment and management. It is uniquely formulated with Carapa Guaianensis Seed Oil found in the Amazon rainforest, an exceptional ingredient that promotes skin renewal, inflammation reduction, and healing. Added emollients and emulsifi-ers allow for versatile compounding for scar and other skin conditions.

SANARE ADVANCED™ BENEFITS:• Provides barrier protection• Increased skin penetration• Formulated for higher loads of polar salt APIs• Skin renewal and inflammation reduction• Soy, gluten, and irritant free• 180-day BUD based on USP 795

SANARE ADVANCED™ PROPERTIES


Physical Format Viscous Gel

Solubility in Water Insoluble

Color Opaque, Off-White

Typical Applications• New Scars • Old Scars • Surgical Scars • Acne Scars • Keloids • Stretch Marks • Scar Tissue • Dermatological Applications

Keloids & Hypertrophic Scars:Betamethasone Valerate 0.1%Tranilast 1%Sanare Advanced qs 100%

Post–Surgical Scars/ New Scars:Collagenase 350 u/gHyaluronidase 250 u/gSanare Advanced qs 100%

Post–Surgical Scars with Pain:Gabapentin 15%Lidocaine 3%Prilocaine 3%Sanare Advanced qs 100%

Age Spots & Wrinkles:Hydroquinone 8%Hydrocortisone 1%Kojic Acid 4%Tretinoin 0.05%Sanare Advanced qs 100%

Rosacea:Metronidazole 1%Niacinamide 4%Sanare Advanced qs 100%

Acne Scars:Lipoic Acid 0.5%Tretinoin 0.1%Sanare Advanced qs 100%

SAMPLE FORMULAS:

Dosage: Apply 2-6 grams topically to affected area 2-4 times daily for 10 to 14 weeks or as directed.

Mixing Tips• Recommended Wetting Agent:Fatty Acid Esters (Isopropyl Palmitate),Fatty Alcohols (Oleyl Alcohol), or Anhydrous Alcohol (Ethanol 200 Proof) Maximum Amount 10%

• Recommended to Reduce Stickiness: Cyclomethicone 5 - 10%

Item No. NDC No. Size Price0112-56 00395-0112-56 500 g $307.20 0112-59 00395-0112-59 2500 g $1372.800112-31 00395-0112-31 5800 g $2825.00

-


Gel Bases &

Ointments

Dosage: Apply 2-6 grams topically to affected area 2-4 times daily for 10 to 14 weeks or as directed.

Lavare™ is a Polyethylene Glycol (PEG) based occlusive, water-sol-uble gel specifically formulated for wound management by promoting a moist environment allowing for optimal healing. Lavare™ contains organic Meadowsweet Extract potentially providing germicidal, anti-inflammatory, and healing properties along with the ability to deliver APIs topically to sensitive wound sites.

LAVARE™ BENEFITS:• Adherent base – occlusive• Water-washable allowing for easy cleaning and debridement• Maintains a moist wound site providing an optimal healing environment• API Compatibility – hydrophilic and lipophilic actives• Soy and gluten free

WATER-WASHABLE WOUND CARE BASE

Item No. NDC No. Size Price7001-62 00395-7001-62 100 g $166.40 7001-56 00395-7001-56 500 g $661.607001-59 00395-7001-59 2500 g $2870.40

LAVARE™-

LAVARE ™ PROPERTIES

pH 6.0


Physical Format Non-Flowable Gel

Solubility in Water Complete

Color White

Typical Applications • Wounds • Ulcers • Burns • Cuts • Abrasions • Dermatological Applications

No Odor/ No Pain:Misoprostol 0.0024%Phenytoin 5%Lavare Gel qs 100%

Odor / No Pain:Misoprostol 0.0024% Phenytoin 5% Metronidazole 2% Lavare Gel qs 100%

No Odor / Pain:Misoprostol 0.0024% Phenytoin 5%Lidocaine 4%Lavare Gel qs 100%

Infected Wound:Misoprostol 0.0024%Phenytoin 5%Gentamicin 0.2%Lavare Gel qs 100%

Infected Wound: Gentamicin 0.1%/gClindamycin 0.1%/gPolymyxin 2,000 u/gLavare Gel qs 100%

Wound Care:Ketoprofen 2%Lidocaine 2%Misoprostol 0.0024%Phenytoin 2%Aloe Vera 0.2%Lavare Gel qs 100%

SAMPLE FORMULAS:

Dosage: Apply up to 4 grams topically 3 times daily as directed, up to 12 grams per day.

Misoprostol – 0.0024% Synthetic analogue of prostaglandin E1, attenuate the inflammatory process and promotes collagen formation by inhibiting IL-1 and TNF, modulates inflammation and decreases wound healing time

Phenytoin – 5% Stimulates collagen deposition, fi-broblast proliferation, glucocorticoid antagonism, and has antibacterial activity

Lidocaine – 4% – Topical anesthetic

Metronidazole – 2% Deodorizing effect of Metronidazole correlate with eradication of anaerobic infection

Nifedipine – 2% Ca2+ channel blocker that greatly improves tissue perfusion and improves healing time

Gentamicin – 0.2% – Antibiotic

Common Actives in Wound Care:

Mixing Tip• Recommended Wetting Agent: Glycerin, Maximum Amount 10%


PLO20 FLOWABLE™Gel Bases

&Ointments

PLO20 Flowable™ is a robust, ready-to-use transdermal base that represents the next generation of pluronic lecithin organogel (PLO) bases. This cosmetically elegant base has a lotion consistency that allows for incorporating high levels of APIs. It contains the same stability properties as PLO20 Non-Flowable™, allowing for versatile compounding. PLO20 Flowable™ provides enhanced chemical penetration that allows a deeper skin permeation than does PLO20 Non-Flowable™. This product is designed to accept the incorporation of high levels of lipophilic actives and moderate levels of hydrophilic actives.

PLO20 FLOWABLE & PLO20 NON-FLOWABLE™ BENE-FITS:• Enhanced penetration – more efficacious drug absorption• API compatibility – high lipophilic & moderate hydrophilic carrying capacity• Adjustable viscosity – PLO20™ & PLO20 Flowable™ may be blended• Temperature & shelf stable• Cosmetically elegant• Validated API compatibility & penetration• No wetting or milling – high levels of oil-soluble powders & moderate levels of water-soluble powders may be directly incorporated

PRE-MADE FLOWABLE PLO

Item No. NDC No. Size Price0135-01 00395-0135-01 1 lb $65.00

Humco's PLO20 Flowable™ ....... 44%Competitor’s Base ........ 39%Traditional PLO ............. 17%

Cumulative % Permeation of

Methimazole through the Stratum Corneum

HUMCO'S PLO20 FLOWABLE™

VS TRADITIONAL PLO

& COMPETITOR'S BASE

PROPERTIES PLO20 FLOWABLE™ PLO20 NON-FLOWABLE™pH 7.0 7.0Specific Gravity 0.97 0.97Viscosity 30,000 cps 300,000 cpsFormat Light Cream/Lotion Heavy CreamColor Light Yellow Light Yellow

Transdermal Penetration + + + + + + + + +


Hydrophilic – 10%Lipophilic – 10%Total API Load – 10%

Best Use High Levels of Lipophilics Low Levels of Lipophilics

Typical Applications• Pain Management• Sports Medicine• Veterinary Medicine

• Pain Management• Sports Medicine• Diabetes & Wound Care• Veterinary Medicine

Ingredients: Isopropyl palmitate, lecithin, poloxamer 407, SD alcohol 40, water and proprietary ingredients

Fluoxetine 5mg/0.1ml

Fluoxetine HCl 5%Grain Alcohol 2%PLO20 Flowable qs 100%

SAMPLE FORMULA:


Gel Bases &

OintmentsPLO20 NON-FLOWABLE™

PLO20 Non-Flowable™ is a ready -to- use, absorption- enhanced transdermal vehicle that is an elegant alternative to PLO transdermal systems. It contains penetration enhancers to facilitate more efficacious active drug absorption, emollients for a better rub- in, preservatives for increased mold resistance, along with emulsifiers allowing for better cold- temperature stability. PLO20 Non-Flowable™ may be blended for viscosity optimization without wetting agents or milling to thin the formula, thus allowing for versatile compounding.

PRE-MADE PLO


Beyond-Use-Date (BUD)ACTIVE INGREDIENT PLO20 FLOWABLE™ PLO20 NON-FLOWABLE™

Diltiazem – 2% – 90 Days

Gabapentin – 6% – 90 Days

Haloperidol – 2% 90 Days –

Ibuprofen – 10% – 60 Days

Ibuprofen – 20% 90 Days 90 Days

Ketoprofen – 10% – 90 Days

Methimazole – 5% 90 Days –

Piroxicam – 1% – 60 Days

Piroxicam – 2% 60 Days –

Prednisolone– 5% – 90 Days

Prednisone – 5% – 90 Days

Prednisone – 10% 90 Days –

Promethazine – 5% – 90 Days

Anti-Nausea/Pain Management Cream:Promethazine 5%PLO20 Non-Flowable qs 100%

SAMPLE FORMULA:

• When you want more efficacious active drug absorption.• When you want to incorporate high levels of lipophilic substances.• When you want a creamier base than a traditional PLO that is more cosmetically elegant and less sticky.• When you want a penetrating cream that can be shipped in cold temperatures.

WHEN DO YOU NEED PLO20™ OR PLO20 FLOWABLE™?

Ingredients: Isopropyl palmitate, lecithin, poloxamer 407, water and proprietary ingredients


UNIVERSAL WATER GEL™

Gel Bases &

Ointments

Universal Water Gel™ is an oil and salt tolerant blend using hydrophobic-inclusive cyclodextrins and electrolyte-tolerant polymers that greatly increases the water solubility and stability of incompatible drugs. Ideal for formulas containing higher levels of oils, botanical ingredients, or poorly soluble actives. It provides improvements in solubility, increase in speed of dissolution, together with physical and chemical stability.

UNIVERSAL WATER GEL™ BENEFITS:• API compatibility – hydrophilic & lipophilic• Excellent electrolyte tolerance• Bioavailability enhancement• Improves active stabilization & compatibility• Highly stable across a broad pH range• Masks the odor of unpleasant actives • Cosmetically elegant• Contains alcohol

VERSATILE TOPICAL GEL BASE


UNIVERSAL WATER GEL™ PROPERTIES

pH 7.0



Physical Format Gel

Color Translucent

Transdermal Penetration +

API CompatibilityHydrophilic & Lipophilic Total API Load - less than 10%

Typical Applications• Dermatology • Pain Management • Diabetes & Wound Care

Ingredients: Alcohol, carbomer, clyclodextrin and purified water

Pain Management:Diclofenac 3%Lidocaine 5%Ethoxy Diglycol 8%Universal Water Gel qs 100%

SAMPLE FORMULAS:

Hormone Therapy:Testosterone 10%Alcohol 10%Universal Water Gel qs 100%

Emulsion Concentrate™ is a pH and salt-tolerant emulsifier/hydrocolloid blend that greatly increases emulsification, stability, and thickness of broken emulsions, and separated and thin formulations. It quickly forms emulsions that are fresh, elegant, fast-absorbing, and non-greasy. EMULSION CONCENTRATE™ BENEFITS:• Ready-to-use polymer in fluid form• API compatibility – virtually all APIs• Elegant sensory profile • Low & high temperature resistant (-5º C – 80º C)• Ingredient compatibility • Broad range of applications

COMPOUNDING ENHANCER

EMULSION CONCENTRATE™


Pre-Mixed Excipient

Bases

Item No. NDC No. Size Price6016-94 00395-6016-94 4 oz $35.00 6016-98 00395-6016-98 8 oz $57.00 6016-28 00395-6016-28 1 gal $800.00

EMULSION CONCENTRATE™ PROPERTIES

pH 4.5 - 6.5


Physical Format Viscous Gel

Color Opaque

Intended Use

• Emulsify all types of oily phases• Stabilize mineral additives• Thicken in adverse conditions – very acidic or very alka-line, oxidizing• Develop fresh formulas that melt on contact with the skin

API Compatibility Virtually all APIs

pH Compatibility 2.0 - 12.0

Salt Tolerance Salt Forms – 35%

Solvent Compatibility Polar & Non-Polar

Temperature Stability Low & High Temperatures

DIFFERENT VISCOSITIES ARE ACHIEVED BY VARYING THE AMOUNT OF EMULSION CONCENTRATE:

3% FOR LOTIONS 5% FOR CREAMS

Ingredients: Proprietary blend of Acrylates, Polysorbate, Starch


MOUTHWASH-GP™Oral

Vehicles

Mouthwash-GP™ is a mouthwash base designed to simplify and standardize the extemporaneous compounding of formulations for delivery to the oral cavity. The pH of Mouthwash-GP™ is buffered to match the natural pH of saliva. The viscous nature of the Mouthwash-GP product allows the pharmacist to dissolve and/or suspend most of the common actives that are prescribed in “Magic Mouthwash”. Mouthwash-GP™ is designed to dissolve or suspend a high amount of active ingredients - maintaining its viscosity when actives are added - such that the oral cavity is coated with medication. The Mouthwash-GP™ packaging container has added head space which allows for mixing of actives by shaking the container.

MOUTHWASH-GP™ BENEFITS:• Oral moisturizer• Coats the mouth• Container head space for mixing • Dye and flavor free• Easily tailored with flavors and colors to improve palatability• Compatible with flavors/dyes that are available for taste-masking of bitter or unpleasant tasting actives

GENERAL PURPOSE MOUTHWASH BASE

Item No. NDC No. Size Price6030-98 00395-6030-98 8 oz $9.74

MOUTHWASH-GP™ PROPERTIES

pH 5.0 - 7.0

Viscosity 1,500 - 4,000 cps

Physical Format Viscous Liquid Solution

Color Clear Liquid

Alcohol Content 10.6% w/w

Intended Use

• Chemotherapy mouth ulcers• Bacterial/viral oral infections• Gingival irritation caused by braces • Throat/esophageal sores

API Compatibility Compatible with most “Magic Mouthwash” actives

Delivery Method Can be expectorated or swallowed

BLM Magic Mouthwash:Diphenhydramine HCl 0.1% Lidocaine HCl 1%Aluminum Hydroxide/ Magnesium Hydroxide/ Simethicone Suspension 37.5%Mouthwash-GP qs 100%

Mary’s Magic Mouthwash:Diphenhydramine HCl 0.25% Hydrocortisone 0.05% Nystatin 0.5% Tetracycline HCl 0.65% Mouthwash-GP qs 100%

Anti-Viral Mouth Rinse:Acyclovir 5% Mouthwash-AF 45% Lidocaine HCl 1% Deoxy D-Glucose 2% Mouthwash-GP qs 100%

SAMPLE FORMULAS:

Flavoring Suggestions?

• For formulations containing Diphenhydramine HCL, use: Banana, Apple, Bubble Gum

• For formulations contain-ing Nystatin/Bio-Statin Suspension, use: Sour Apple, Watermelon, Cherry

• For formulations contain-ing Corticosteroids, use: Bubble Gum, Grape, Apple

• For formulations contain-ing Antibiotics, use: Grape, Watermelon, Strawberry


Oral Vehicles

MOUTHWASH-OM™

Mouthwash-OM™ is a mouthwash base designed to aid symptoms of Oral Mucositis associated with cancer therapy and certain dental conditions. In addition to being alcohol-free, Mouthwash-OM™ contains excipients that are compatible with water-soluble drugs for the treatment of oral pain, mouth sores, and oral infections. MOUTHWASH-OM™ BENEFITS:• Soothing oral moisturizer• Alcohol-free - no burn• Container head space for mixing • Dye and flavor free• Contains botanical extracts• Compatible with flavors/dyes that are available for taste-masking of bitter or unpleasant tasting actives• May be expectorated or swallowed

MOUTHWASH BASE FOR ORAL MUCOSITIS


MOUTHWASH-AF™ALCOHOL-FREE MOUTHWASH BASE FOR HYDROPHOBIC ACTIVESMouthwash-AF™ is a mouthwash base designed to provide solubility of hydrophobic active ingredients while being compatible with the oral mucosa. In addition to being alcohol-free, Mouthwash-AF™ contains excipients that dissolve and coat the mouth with drugs for the treatment of oral pain, mouth sores, and oral infections. MOUTHWASH-AF™ BENEFITS:• Solubilizers for hydrophobic actives• Alcohol-free - no burn• Container head space for mixing • Dye and flavor free• Compatible with hydrophobic and hydrophilic actives• Compatible with flavors/dyes that are available for taste-masking of bitter or unpleasant tasting actives• May be expectorated or swallowed


SAMPLE FORMULAS:

Pain Relief Gargle: Lidocaine HCl 1.5%Sucralfate 5%Diphenhydramine HCl 0.5%Mouthwash-OM qs 100%

Xerostomia Rinse: Pilocarpine HCl 1%Mouthwash-OM qs 100%

SAMPLE FORMULAS: Esophageal Suspension:

Budesonide 0.1%Mouthwash-GP or AF qs 100%

Anti-Infective Mouthwash: Nystatin 1% Tetracycline HCl 2% Acyclovir 5% Deoxy D-Glucose 2%Mouthwash-AF qs 100%


FLAVOR SWEET™Oral Vehicles

Flavor Sweet™ is a cherry-flavored syrup vehicle formulated to simplify the preparation of oral extemporaneous delivery systems. It may be used alone or in conjunction with other agents to give flavor and sweetness while increasing the suspension’s physical stability. Flavor Sweet™ contains suitable preservatives and is buffered to a slightly acidic pH to provide a dependable and consistent vehicle. • Pink colored, cherry flavored syrup• pH 4.5 – pH 5.0• Recommended use – hydrophilic, acid-stable & hydrophobic actives

SYRUP VEHICLE

Item No. NDC No. Size Price0090-16 00395-0090-16 16 oz $9.55 0090-28 00395-0090-28 1 gal $62.00

FLAVOR SWEET-SF™Flavor Sweet SF™ is a sugar-free and alcohol-free cherry flavored syrup. It may be used alone or in conjunction with other agents to give flavor and sweetness while increasing the suspension’s physical stability. Flavor Sweet SF™ contains suitable preservatives and is buffered to a slightly acidic pH to provide a dependable and consistent vehicle. • Pink colored, cherry flavored, sugar-free syrup• pH 4.5 – pH 5.0• Recommended use – hydrophilic, acid-stable & hydrophobic actives• Ideal for diabetic preparations

SUGAR-FREE SYRUP VEHICLE

VERSA FREE™

Versa Free™ is a dye-free, flavor-free, paraben-free, sugar-free, gluten-free and saccharin-free syrup vehicle resulting in fewer patient allergic reactions. Virtually no aftertaste.• Flavor-free clear liquid syrup• pH 4.5 – pH 5.0• Natural ingredients & natural preservatives• Recommended use – hydrophilic, acid-stable & hydrophobic actives• Ideal for diabetic, autistic, & allergy-sensitive patients• Soy & gluten-free

DYE-FREE, CHEMICAL-FREE, AND SUGAR - FREE SYRUP VEHICLE



Ingredients: Sucrose, Purified Water, Glycerin, Sorbitol, Flavoring, FD%C Red #33, and FD&C Yellow #6. Buffered with Sodium Phosphate and Citric Acid. Preserved with Methylparaben and Potassium Sorbate.

Ingredients: Purified Water, Glycerin, Sorbitol, Flavoring, Sodium Saccharin, Xanthan Gum, FD&C Red #40, and FD&C Yellow #6. Buffered with Citric Acid and Sodium Citrate. Preserved with Methylparaben (0.03%), Propylparaben (0.008%), and Potassium Sorbate (0.1%).

Ingredients: Purified Water, Glycerin, Sorbitol, Xantham Gum, and Neotame. Buffered with Sodium Citrate and Citric Acid. Preserved with Potassium Sorbate and Sodium Benzoate.


Oral VehiclesFLAVOR PLUS™

ORAL SUSPENDING VEHICLEFlavor Plus™ is a unique flavor-free, aqueous based suspending vehicle used to simplify the process of compounding oral non-soluble suspensions. It is buffered to an acidic pH providing a uniform, consistent and stable vehicle.• Flavor-free, white liquid suspension• pH 3.5 – pH 4.0• Recommended use – hydrophilic, acid-stable & hydrophobic actives• Ideal for diabetic preparations

FLAVOR BLEND™ALL-IN-ONE SYRUP/SUSPENDING VEHICLEFlavor Blend™ is a uniquely formulated flavored oral suspending vehicle designed to simplify the extemporaneous compounding process of oral suspensions. It combines the flavoring agents of Flavor Sweet™ and the suspending agents of Flavor Plus™, along with preservatives and an anti-foam agent to provide an easy preparation of smooth, elegant oral suspensions. • Easy to use• Light pink liquid blend with a cherry flavor• pH 4.5 – pH 5.0• Recommended use – hydrophilic, acid-stable & hydrophobic actives• Incorporate virtually all medicated powders or crushed tablets• Ideal for pediatric & geriatric preparations

VERSA PLUS™DYE-FREE, CHEMICAL-FREE, AND SUGAR - FREE SUSPENSION VEHICLEVersa Plus™ is a dye-free, flavor-free, paraben-free, sugar-free, gluten-free and saccharin-free suspension vehicle resulting in fewer patient allergic reactions. Virtually no aftertaste.• Flavor-free white liquid suspension• pH 3.5 – pH 4.0• Natural ingredients & natural preservatives• Recommended use – hydrophilic, acid-stable & hydrophobic actives• Ideal for diabetic, autistic, & allergy-sensitive patients• Soy & gluten-free




Ingredients: Purified Water, Microcrystalline Cellulose, Sodium,Carboxymethylcellulose, Xantham Gum, and Carrageenan. Buffered with Citric Acid and Sodium Phosphate. Preserved with Potassium Sorbate and Methylparaben.

Ingredients: Purified Water, Sucrose, Glycerin, Sorbitol, Flavoring, Microcrystalline Cellulose, Carboxymethylcellu-lose sodium, Xantham gum, Carageenan, Calcium Sulfate, Trisodium phosphate, and simethicone. Buffered with Citric Acid and Sodium Phosphate. Preserved with Methylparaben and Potassium Sorbate.

Ingredients: Purified Water, Microcrystalline Cellulose, Cara-geenan, Carboxymethycellulose sodium, and Xantham Gum. Buffered with Citric Acid and Sodium Phosphate. Preserved with Potassium Sorbate and Sodium Benzoate.


ADDITIONAL ORAL VEHICLES

Oral Vehicles

Cherry Syrup™Recommended Use: Ionic & Hydrophilic Actives

Sucrose 82% w/v, purified water, artificial cherry flavors, citric acid, FDC Red #40, sodium benzoate as a preservative, inert ingredients and natural preservatives

Item No. Size Price 2662-16 16 oz $12.002662-28 1 gal $65.00

Raspberry SyrupRecommended Use: Ionic & Hydrophilic Actives

Sucrose 82% w/v, purified water, artificial raspberry flavors, citric acid, FDC Red #40, FDC Blue #1, sodium benzoate as a preservative, inert ingredients and natural preservatives.

Item No. Size Price 2664-16 16 oz $14.25

Simple SyrupRecommended Use: Ionic & Hydrophilic Actives

Sucrose 85% w/v, citric acid, purified water, methyl paraben as a preserva-tive along with natural preservatives.

Item No. Size Price 2662-16 16 oz $12.002662-28 1 gal $65.002661-75 5 gal $180.00

Sorbitol Solution70%, USPRecommended Use: Ionic & Hydrophilic Actives, Diabetic Additives

Natural ingredients and preservatives — 70% solution of sorbitol and purified water.


Syrpalta (red)Recommended Use: Ionic & Hydrophilic Actives

Sucrose 83% w/v, purified water, glycerin, artificial flavors, 0.2% alcohol, 0.1% sodium benzoate, 0.001% benzalkonium chloride as a preserva-tive and inert ingredients.


Syrpalta (without color)Recommended Use: Ionic & Hydrophilic Actives

Sucrose 83% w/v, purified water, artificial flavors, 0.2% alcohol, 0.1% sodium benzoate, 0.001% benzalko-nium chloride as a preservative, inert ingredients and natural preservatives.


Product Ingredients Ordering Information

WWW.HUMCO.COM • +1 (855) 925-4736 • VERSION 1.0 • HUMCO 43

Miscellaneous Ingredients

ADDITIONAL CMPDG INGREDIENTS

Almond Oil Sweet, NF Item No. Size Price 1907-91 1 oz $5.691907-16 16 oz $40.43

Arnica Tincture Item No. Size Price 0115-94 4 oz $34.48

Barium Sulfate Powder USP Item No. Size Price 0200-01 1 lb $53.45

Benzoin Compound Tincture USP Item No. Size Price 0243-92 2 oz $6.230243-16 16 oz $42.34

Bismuth Bicarbonate Powder Item No. Size Price 0261-01 1 lb $136.83

Coal Tar Topical Solution USP Item No. Size Price 0617-16 16 oz $24.18

Glycerin USP Item No. Size Price 1031-96 6 oz $5.821031-28 1 gal $102.161031-75 5 gal $150.07

Iodine Tincture, Mild 2% USP Item No. Size Price 1213-91 1 oz $2.451213-16 16 oz $23.17

Mineral Oil Light Item No. Size Price 1673-28 1 gal $101.68

Sweet Oil (Olive Oil) Item No. Size Price 1997-94 4 oz $7.701997-28 1 gal $46.55

Peruvian Balsam Item No. Size Price 2255-94 4 oz $34.56

Polyethylene Glycol 300 Item No. Size Price 2335-75 5 gal $238.67

Propylene Glycol Item No. Size Price 2327-28 1 gal $36.48

Salicylic Acid Powder USP Item No. Size Price 2625-94 4 oz $12.312625-01 1 lb $39.03

Strong Iodine Solution (Lugol's) * Item No. Size Price 2775-16 16 oz $56.20

* To purchase this item you must have a DEA license on file

HUMCO GLOBAL HEADQUARTERS201 West 5th Street, Floor 12Austin, TX 78701

+1 (855) 925-4736 www.Humco.com

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