Precision Medicine PathwayCo-Directors: Tim Schedl (Genetics) Chris Gurnett (Neurology) John Welch (Medicine)

Goal:Introduce students to the uses of genomic and genetic information in the diagnosis and treatment of disease, from current concepts and practice to gaps that need to be filled in achieving precision medicine.

Precision Medicine PathwayCo-Directors: Tim Schedl (Genetics) Chris Gurnett (Neurology) John Welch (Medicine)

Purpose:- Expand/extend your educational experience in the

areas of genetics, genomic & bioinformatics related to medicine. (need not have any relationship to your thesis research)

- For some students, make clinical connections related to thesis research.

- Provide career path information, for postdoctoral research areas or alternatives to traditional PI track.

Pathway components

1. Course, fall of 1st and 2nd years 2. Journal club, spring 1st year, year 23. Clinical connections, spring 1st year, year 2 4. Retreat (yearly)

1. Genetics & Genomics of Disease course (Bio 5487) FallMonday & Wednesday, 3:00 – 5:00 (Fall)Round table presentation/discussion

For class topics see http://pmpathway.wustl.edu/class-information-2016/

Examples:- Translational medicine & ALS clinical trials – Tim Miller, Neurology- Viral metagenomics - Lori Holtz, Pediatrics

- Ethics panel, - Career panel, - Identify likely pathogenic lesion(s) in deidentified patient sequenceinformation (Mendelian case and a cancer case) using the WU Genome Pathology Services analysis platform.

Demonstration of pre-implantation genetic diagnosis at the Washington University Fertility and Reproductive Medicine Center

2. Journal club (meets every two weeks)- Attend Human Genetics Journal club - spring year 1, fall & spring year 2 - present in spring year 2

3) Clinical connections a) Attend recurring clinical conferences (1 per month)- Genomics Tumor Board (3rd Thurs each month)- Pediatric Genetics Conference (every Mon)(Spring 1st year, Fall & Spring of 2nd year)

b) Shadowing a clinician (spring year 1 – year 2)

c) Clinical mentored project (year 2) [Optional]

4) Retreat (October 5, 2017)

- Richard Gibbs Director of Human Genome Sequencing Center, Keynote speaker

- Presentation by students in the second year of the Pathway (either on Thesis research or Clinical mentored project.)

Current Students:

2014 – 2016 2015 – 2017 2016 - 2018Ben Ainscough Damien Abreu Katie CampbellMatt Bailey Lilian Antunes Umber DubeKirsten Brenner Mayank Choudhary Yiran Hou Drew Hagan Brian Earley Emily LewisChristina Mikulka Jennifer Flynn Yang LiManishi Pandey Steven Foltz Cody Ramirez Ji Woong Park Liron Ganel Jimmy WeagleySarah Pyfrom Yu He Wu-Lin Charng Nicole Rockweiler Wen-Wei Liang

Details on Eligibility and the Application to the PrecisionMedicine Pathway can be found on the DBBS Website – Special Emphasis Pathways section

Application due date, June 15.

Will accept up to 10 students.

Eligibility:- Students applying at the end first year of graduate school must be good academic standing. - Students applying at the end second year of graduate school must have completed Program-specific QE. - Students are strongly encouraged to have completed one or more of the following courses: Genomics (Bio 5488), Advanced Genetics (Bio 5491) or Fundamentals of Mammalian Genetics (Bio 5285)

- All interested students should apply.

Application: - Name, birth date, address, academic program and year and citizenship. - Contact information (e-mail and telephone) - PI in which thesis work is being conducted- CV or resume (include a list of graduate courses taken and grade)- Paragraph description of why student is interested in the Pathway- Paragraph description of thesis research*. - Assemble these components into a single PDF, and send to <pmpathway@genetics.wustl.edu>- Two letters of recommendation, one of which is from the thesis advisor*, should be sent directly to <pmpathway@genetics.wustl.edu>

All application material should be submitted by June 15, 2017, to <pmpathway@genetics.wustl.edu>

* If you have not yet joined a thesis laboratory then a rotation lab project and a rotation advisor can be used as a substitute.