1. Precision Behavioral Medicine Dr. Eric Hekler Arizona State University National Physical Activity Plan Congress February 24, 2015 @ehekler 2. @ehekler 3. Why now for Precision Behavioral Medicine? Flickr Stuck in Customs Digital health technologies are pervasive and personal and have the potential to be powerful. @ehekler Health behaviors explain the most in individual health variations. 40 15 5 10 30 Sub-Optimal Health behaviors Social Circumstances Environmental Exposures Healthcare Genetics McGinnis, et al. 2002 Health Affairs 4. What is a precise physical activity intervention? @ehekler Just in time Adaptive Flickr -Casgen 5. What are the pieces of precision? Flickr -Eldeem 6. The pieces Technologies to sense & provide feedback Whats my goal right now? When is now? What will help right now? How do I choose the right option for now? How to study fit between interventions and persons/context? @ehekler 7. Individualized Recommendations Whats my goal right now? Hekler, et al. 2013 Health Education and Behavior @ehekler 8. Decision points When is now?/ When is NOT now? Nahum-Shani, Hekler, & Spruijt-Metz, under review. @ehekler 9. Intervention Options What will help right now? Nahum-Shani, Hekler, & Spruijt-Metz, under review. @ehekler 10. Decision Rules How do choose the right option for now? Hekler & Rivera, NSF EAGER @ehekler 11. Statistical Reinforcement Learning Lab University of Michigan Research: Just In Time Adaptive Interventions (JITAI) Micro-Randomized trial designs and data analysis methods for JITAI development https://community.isr.umich.edu/public/jitai/Workshop.aspx Inbal (Billie) Nahum-Shani Susan MurphyDanny Almirall Pedja Klasnja Ambuj Tewari 12. Just In Time Adaptive Intervention (JITAIs) Individualized treatments delivered when-ever and where-ever the individual needs help, via a wearable device (e.g., smartphone). + Advancing: Micro-randomization trial designs Data analysis methods for constructing good decision rules. Online training algorithms that will personalize decision rules. https://community.isr.umich.edu/public/jitai/Workshop.aspx 13. How to study fit between interventions and persons/context? @ehekler Build and evaluate the perfect intervention. Build and evaluate the pieces of the intervention. Flickr -EldeemFlickr -Pascal 14. Agile Science www.agilescience.org 15. @ehekler We can only make precision behavioral medicine together! 16. The pieces Technologies to sense & provide feedback Whats my goal right now? When is now? What will help right now? How do I choose the right option for now? How to study fit between interventions and persons/context? @ehekler 17. We can only achieve precision behavioral medicine together. Dr. Eric Hekler Arizona State University ehekler@asu.edu @ehekler Flickr -Espen_Faugstad@ehekler