ppt _vitamin b₃ ( niacin )

8/17/2019 ppt _VITAMIN B₃ ( NIACIN )

http://slidepdf.com/reader/full/ppt-vitamin-b-niacin- 1/13

VITAMIN B₃ (NIACIN)Oleh:

Muh.Ihsanuddin



Introduction

ac a! e an e coen*!e or!s o e a! n.Nicotina!ide is the actie &or!" which &unctions as a constituent o&twocoen*!es" na!el" nicotina!ide adenine dinucleotide (NA+) andnicotina!ide adeninedinucleotide 'hos'hate (NA+,). In the &or!s o& these coen*!es"niacin &unctions in!an biolo%ical redo reactions which actiate about dehdro%enases essential toelectron trans'ort and other cellular res'irator reactions. NA+&unctions as an electroncarrier &or intracellular res'iration as well as a co-&actor &or en*!esinoled in theoidation (catabolis!) o& &ats" 'roteins" carbohdrates and alcohol to'roduce ener%.NA+, &unctions as a hdro%en donor in reductie biosnthesis(anabolis!)" such as in

&att acid and steroid snthesis. /i#e NA+" NA+, is a co&actor &oren*!es" such as inthe oidation o& %lucose-0-'hos'hate to ribose-1-'hos'hate in the'entose 'hos'hate'athwa.In non-redo reactions" NA+ is the substrate &or two classes o&

en*!es thatse'arate the niacin !oiet &ro! NA+ and trans&er A+,-ribose to



2. 3i&at #i!ia dan stabilitas



3tru#tur 4i!iaNiacin



356A7A8 ......Asa! ni#tinattelah di#enal oleh 'ara

ahlibio#i!ia se9a# tahun 20;"teta'i 'en%enalanna seba%ai suatu

ita!in anti-'elar%a baru di!ulaitahun 2<$;. Terda'at dua stru#tur

!ole#ul an% !e!'unaibioa#tiitas ita!in ini" ialah sa!

ni#'tinat (ni#otinic acid)" dan a!ida

asa! ni#otinic (ni#otinic acida!ide). Tr'to'hane ternata!eru'a#an bentu# 'roita!in ba%iniacin= 0 !% tr'to'hane setara

den%an 2 !% niacin.



Absorbsi > si!'anan

AbsorbsiNiacin

+i dala! usus halus" niacin dihidroisis dan di absorbsi

seba%ai asa! ni#otinat"ni#otina!ida danni#otina!ida !ononuleotida( MMM )

!etabolis!e

Niacin dan 're#ursorna larutdala! air sehin%%a !udah disera'#e dala! !u#osa dindin% usus halusdan

+ialir#an lebih lan9ut #e dala! hati!elalui ena 'ortae % terda'atdala! 9arin%an berbentu# NA+, II

4dar Ni#otina!ida di dala! darahlen%#a' ( seba%ai NA+ dan NA+, )sebesar $1 ?%@!l

+i ala! 'las!a darah terda'at 0-< u%!l ,ada #ondisi ber'uasa terda'at

Nasin bebas da la! 'las!a darahsebesar "21 u%!l

+i dala hati seba%ai #adar niacin

tertin%%i 1 u% %" dan 9antun%"in al" otot scaleb > otot licin



Metabolis!e

Niacin die#s#resi#an didala! urine dala! bentu#

N!ehthl niacina!ide ( N-Me). +ala! #atabolis!aniacin" !etabolis!e N-Medi'ecah lebih lan9ut !en9adiberba%ai 9enis !etabolitan% belu! benar

identitasna. +i dala!urine" di sa!'in% N-Medie#s#resi#an 9u%a 'ridonedan bebera'a !etabolitelain dala! #uantu! #ecilan% bentu#na belu!

teridentiD#asi.

NetEE....



F?NG3I .....

Niacin ber&un%siseba%ai

4oen*i! NA+> NA+,

!etbolis!e 'rotein"

asa! le!a#"'erna&asan sel dan

deto#siD#asi"

rea#si o#sidasi-

redu#si 'ada%li#olisis"



3?MB57 .....

da%in%" aa!8atii#an"#acan% tanah.Gin9al

i#an"8ati#acan% tanah.Gin9alda%in%" aa!

Lihat tabel nilai niacin dalam berbagai bahan makanan....



Tabel Nilai niacin berbagai bahan makananmg/100 gram )

Bahanmaanan

Mg Bahan makanan mg

4acan tanahlo#al

2$" Aa! "

Teri nasi

#erin%

<"; +a%in% babi "0

3ardin ;"0 +a%in% sa'i "1

I#an #e!bun% 0"1 8ati sa'i 2"

I#an banden% 1" 8ati aa! 2"

I#an #e!bun% " Gin9al #a!bin% "

I#an selarse%ar

"< Gin9al sa'i 0";

I#an tawesse%ar

" Beras $"

?dan% se%ar " Te!'e H#acan% #edelai $"0

,eris udan% " 4acan% tanah "



Food Niacin (mg/100g)

Peanut : 22.;Ancho!" dried : 2$.#ier : 22.1$heat %our" &hole'meal : 2.Bee etract : 1.0Pomret" black (ba&al hitam) : .*ardine" canned : $.1

Bee" lean : $.Mackerel (Tenggiri batang) : $. +hicken" brea,t meat : $.2

(Source: Tee et al.,

1997)

Net....



4elebihan > #e#uran%an .....

4elebihan #e#uran%an niacinda'at !enebab#an:

4elebihan2. Meracuni siste! sara& . /e!a# darah$. Gula darah. Gan%%uan &un%ssi

hati1. Te#anan darahrendah

4e#uran%an2. 'rodu#si ener%i#uran%

#arena 'roser%li#olisis la!bat

. !enebab#an&un%si ota# le!ah

$. 'ela%ra. +iare1. de!entia



T57IMA 4A3I8 .....

ppt _vitamin b₃ ( niacin )

Documents