powerpoint presentation · actinobacteria, bacteroidetes, firmicutes, proteobacteria . foodomics...
TRANSCRIPT
![Page 1: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/1.jpg)
![Page 2: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/2.jpg)
^[now][transl|comput]ational[epi]genomic$
![Page 3: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/3.jpg)
Lab for Bioinformatics and
computational genomics
30 “genome hackers” mostly engineers (statistics)
>100 people Hardware/software engineers,
mathematicians, molecular biologists
scientists, technicians, geneticists, clinicians
dewpal/aerolis
^[now][transl|comput]ational[epi]genomic$
![Page 4: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/4.jpg)
Math
Informatics
Theoretical Biology
Computational Biology
(Molecular)
Biology
Computer Science
Bioinformatics
Discovery Informatics
^[now][transl|comput]ational[epi]genomic$
![Page 5: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/5.jpg)
Math/Chemistry/Biology
Genomics
Food Science
Food-omics 2.0
Nutrition
Bioinformatics
Nutri(epi)genomics
^[now][transl|comput]ational[epi]genomic$
"a discipline that studies the Food and Nutrition domains through the application and integration of
advanced -omics technologies to improve consumer's well-being, health, and knowledge".
![Page 6: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/6.jpg)
![Page 7: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/7.jpg)
![Page 8: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/8.jpg)
![Page 9: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/9.jpg)
Foodomics 2.0
• Genetics • Nutrigenomics • Examples
• Epigenetics • Nutri-epigenetics • Examples
• Metagenomics • Nutri-metagenomics • Examples
• Foodomics 3.0 • Technology • Big Data / AI
![Page 10: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/10.jpg)
5 years ago …
![Page 11: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/11.jpg)
Consumer Genomics Market Expanding Rapidly
MIT Technology Review
Source: 1) https://www.technologyreview.com/s/610233/2017-was-the-year-consumer-dna-testing-blew-up/; 2) Illumina @ JP Morgan Healthcare 2018
![Page 12: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/12.jpg)
What can Consumer Genetic Testing Offer?
Source: https://www.sciencedirect.com/science/article/pii/S2212066116300011
![Page 13: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/13.jpg)
All-in-One Interface Health Risk Genetic Traits Pharmacogenetics Genealogy
Wobblebase’s mission is to bridge the gap between consumers and medical professionals to leverage genetic information to its fullest
potential.
myWobble, GeneWall
![Page 14: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/14.jpg)
Use camera to identify Pill Get “Insert” from database Get pharmacogenomics SNPs Check your SNPs AR / Report
![Page 15: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/15.jpg)
Use barcode to identify product Get ingredients Check your SNPs against ingredients - Sensitivities
- eg peanut - allergens
- Metabolic compatibility AR / Report
![Page 16: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/16.jpg)
Foodomics 2.0
• Genetics • Nutrigenomics • Examples
• Epigenetics • Nutri-epigenetics • Examples
• Metagenomics • Nutri-metagenomics • Examples
• Foodomics 3.0 • Technology • Big Data / AI
![Page 17: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/17.jpg)
©2018 All rights reserved
17
Relative importance of (Epi)genetics (i)
![Page 18: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/18.jpg)
©2018 All rights reserved
Relative importance of (Epi)genetics (ii)
• Epigenetics enables to reuse one
genome for many different
purposes
• Epigenetics driving etiology of many
human diseases
![Page 19: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/19.jpg)
©2018 All rights reserved
19
• Actionability* and integration of
intrinsic with environmental signals
Relative importance of (Epi)genetics (iii)
![Page 20: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/20.jpg)
![Page 21: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/21.jpg)
![Page 22: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/22.jpg)
©2018 All rights reserved
22
![Page 23: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/23.jpg)
Phyto-oestrogens
• Structure – natural products are
mixtures
• α- en β-receptors
• Epigenetic modifier ?
base structure isoflavonen 8-prenylnaringinine (PN) 17-β-estradiol.
![Page 24: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/24.jpg)
Method
MCF-7 cellen MDA-MB-231 cellen ER+ ER-
![Page 25: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/25.jpg)
Data analysis
• 450K Beadchip array (Illumina)
• Dose-response curves with active
compound (8-PN)
![Page 26: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/26.jpg)
![Page 27: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/27.jpg)
Fermented Soy
Active metabolite Equol
Equol: natural agonist ER-beta receptor
anti-proliferation and anti-inflammatoir
effect
Evidence based phytotherapy
![Page 28: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/28.jpg)
Foodomics 2.0
• Genetics – Nutrigenomics – Examples
• Epigenetics – Nutri-epigenetics – Examples
• Metagenomics – Nutri-metagenomics – Examples
• Foodomics 3.0 – Technology – Big Data / AI
![Page 29: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/29.jpg)
![Page 30: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/30.jpg)
We Are More Bacteria Than Human •Healthy adult harbors ~100 trillion bacteria in gut
alone (10x the number of human cells we possess) •Communal gut microbial genome (microbiome) is
~150 times larger than human genome •Reasonable to view microbiome as an organ • Is dominated by 4 large groups of bacteria:
Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria
![Page 31: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/31.jpg)
![Page 32: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/32.jpg)
![Page 33: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/33.jpg)
![Page 34: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/34.jpg)
![Page 35: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/35.jpg)
![Page 36: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/36.jpg)
Foodomics 2.0
• Genetics • Nutrigenomics • Examples
• Epigenetics • Nutri-epigenetics • Examples
• Metagenomics • Nutri-metagenomics • Examples
• Foodomics 3.0 • Technology • Big Data / AI
![Page 37: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/37.jpg)
![Page 38: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/38.jpg)
![Page 39: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/39.jpg)
![Page 40: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/40.jpg)
![Page 41: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/41.jpg)
![Page 42: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/42.jpg)
![Page 43: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/43.jpg)
![Page 44: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/44.jpg)
Add textmining (patents), phylogenetic data
![Page 45: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/45.jpg)
![Page 46: PowerPoint Presentation · Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria . Foodomics 2.0 •Genetics •Nutrigenomics •Examples •Epigenetics •Nutri-epigenetics •Examples](https://reader030.vdocuments.site/reader030/viewer/2022041008/5eb08f4e67624815a02bc72c/html5/thumbnails/46.jpg)
Math/Chemistry/Biology
Genomics
Food Science
Food-omics 2.0
Nutrition
Bioinformatics
Nutri(epi)genomics
^[now][transl|comput]ational[epi]genomic$
"a discipline that studies the Food and Nutrition domains through the application and integration of
advanced -omics technologies to improve consumer's well-being, health, and knowledge".
?