potentiating the immune system in children: bringing up a better future through ayurveda abhimanyu...
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POTENTIATING THE IMMUNE SYSTEM IN CHILDREN:
bringing up a better future through Ayurveda
Abhimanyu Kumar MD(Ay), MSc(Psy),PhD
The
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fect
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HUMAN BEINGS HAVE CROSSED THIS BOUNDARY OF NATURE
BY ADOPTING UN-NATURAL WAYS
The Real World
COLD
FLU
CHICKEN POX
STOMACH UPSET
HELP ME !
HELP !
HELP ME!
The Perfect World The Real World
COLD
FLU
CHICKEN POX
STOMACH UPSET
HELP ME !
HELP !
HELP
ME!
AYURVEDA WAY OF LIFE TELLS US TO UNDERSTAND AND MAINTAIN OUR LIMITS FOR SUSTAINING HARMONY
WITH
NATURE
• The childhood period is the foundation of the life and it is here only the seeds for healthy life should be laid down.
• Proper nutrition, absence of any of the psychosomatic disease and a healthy psychological development are the main domains on which the growth and development of a child is based upon.
Major causes of childhood morbidity & mortality
• Acute respiratory infections (ARI)
• Diarrhea (dehydration)
• Anemia
• Malnutrition
• Poor growth and development (physical & mental)
Acute Lower Respiratory Tract infection (Pneumonia)
• Acute Lower Respiratory Tract infection (Pneumonia) is a leading cause of mortality in children below 5 years of age.
Poor immunity
IMMUNITY IN AYURVEDA
• Vyadhikshamatva (immunity) is interpreted as-
– Vyadhibala virodhitva (antagonistic to strength and virulence of disease) and
– Vyadhi utpada pratibandhakatva (the capacity to inhibit or neutralize or resist or overcome disease causing agents).
This vyadhikshmatva depends on the presence of bala or oja in the body. Oja represents vitality, vigor and capacity to resist decay and disease.
PRAKRITI & IMMUNITY STATUS
Status of Bala (strength/immunity) in different Prakriti
PRAKRITI BALA(STRENGTH/IMMUNITY)
VATA MINIMUM
PITTA MODERATE
KAPHA SUPERIOR
VATA AND PITTA INFERIOR
VATA AND KAPHA MODERATE
PITTA AND KAPHA SUPERIOR
CLINICAL STUDY OF IMMUNOMODULATORY EFFECT OF AN
AYURVEDIC COMPOUND (VAYASTHADI YOGA) IN CHILDREN
Aims and objectives• The main objective of the research to evaluate the immunomodulatory
effect of ayurvedic compound Vayasthadi yoga in children.
Plan of study-
Selection of case• Source – children for the study were screened out from the OPD and IPD
of Kaumarbhritya department of NIA Jaipur• Age group • Children between 06 months to 08 years were selected for the study• Number of case• Total 61 cases were screened out of which 16 number of cases were
discontinued (Final study cases 55).
Grouping of patients• Screened patients were randomly divided into two groups• GROUP A- this group were given the trial drug Vayasthadi yoga (V1)• GROUP B-this group of children were given the placebo.
Inclusion criteria• Age 06 months to 08 years• Cardinal features of immunodeficiency• History of at least three episodes in last two months
Exclusion criteria• Acute and severe infection• Severe malnutrition• Tuberculosis• Infections associated with congenital heart diseases• Specific nasal pathology – deviated nasal septum etc• Malignancies
Discontinuation criteria• Appearance of any major illness during the study period
Side-effect evaluation criteria• To rule out possible side effects t he study drug, clinical criteria
was adopted. It included the documentation of information from the patient on every follow-up, related to features as tachycardia, tremor, headache, sedation, drowsiness, oral thrush etc.
Clinical assessment • Assessment of clinical symptoms, running nose,
sore throat, nasal obstruction, enlarged tonsils, cough, dyspnea, fever and diarrhea depending on the severity was done on four-point scale. Calculation of final score was calculated using following formula
Final score= frequency x severity
Laboratory assessment• Serum immunoglobulin G (IgG)
Study Drug
An Ayurvedic classical formulation containing nine drugs was selected for the study. The drugs used in the preparation of the formulation are
» Haritaki» Pippali» Kustha» Haridra» Sariva» Vacha» Jatamansi» Kaidarya» Brahmi
• Formulation was prepared in the form of syrup in order to enhance its palatability and easy administration in children. This formulation was named vayasthadi yoga (V1)
• Dose – 01 ml/kg body weight in two divided doses
• Duration of trial – 02 months
• Follow up- follow up was done every fortnightly during the trial period and after two months of completion of the therapy.
• Placebo – the placebo for the study was also prepared in the form of syrup named as vayasthadi yoga (V2) composed with the combination of sugar and water .
IgG (mg/dl) AT-BT
Group A
No. %
Group B
No. %
<0 00 00 02 20
0-50 02 20 03 30
50-100 06 60 04 40
100-150 00 00 00 00
150-200 00 00 01 10
>200 02 20 00 00
Status of IgG in both the groups after treatment
Statistical status of the overall effect in both the groups (inter-group)
Groups Mean Score
BT AT
Mean %
N SD SE t p
A 9.27 4.18 44.09 12 1.16 0.33 12.48 < 0.001
B 8.68 8.59 1..04 12 0.22 0.06 1.44 .>0.1
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Thank you