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Washington, DC 20005

POSITIONS OPEN

ANATOMIST/NEUROBIOLOGISTThe Department ofAnatomy, Wright State University

Medical School, invites applications for a tenure-trackfaculty position at the ASSISTANT PROFESSORlevel. The applicant should have a Ph.D., M.D., orequivalent degree with postdoctoral experience in neuro-biology. Preference will be given to individuals withresearch interests in neurobiology or endocrinology us-ing contemporary cellular or molecular approaches. Thecandidate will be expected to carry on an active researchprogn and to attract extramural funding. Primaryteaching responsibility will be in neuroscience. Womenand minorities are encouraged to apply. Applicants shouldsubmit their curriculum vitae, research interests, threerecent reprints, and the names of three references by 15December 1990 to:John C. Pearson, Ph.D., Chairer, Search Committee

Department of AnatomyWright State University School of Medicine

Dayton, OH 45435Wright State University is an Equal OpportunityAfrmative

Action Employer.Texas. ANATOMIST. Full-time, tenure-track posi-

tion. Applicts should hold Ph.D. or M.D. degree,record of productive research in behavioral neuroscienceinvolving primates and teaching experience in an ana-tomic discipline. Preference given to neuroanatomy.Salary commensurate with qualifications and appoint-ment at associate professor level.Send complete curriculum vitae, including names of

three professional references, to: Dr. L. Steele Russell,Interim Head, Department of Anatomy, Coliege ofMedicine, Texas A&M University, College Station,TX 77843.

Texas A&M University is an Equal Opportunity/AfJir-mative Action Employer.ASSISTANT PROFESSOR OF INORGANIC

CHEMISTRY. Harvard University invites applicationsfor an assistant professorship in any area of inorganicchemistry. Applicants should arrange to have three lettersof recommendation sent independently and should pro-vide curriculum vitae and brief descriptions of futureresearch plans. Harvard University is an Affirmative ActionlEqual Opportunity Employer. Applicants from women andminoritygroup members are wekome. Applications and sup-porting material should be sent no later than 30 Novem-ber 1990 to: Professor R. H. Holm, Departnent ofChemistry, Harvard University, 12 Oxord Stret,Cambridge, MA 02138.

The Division of Rheumatology in the Department ofMedicine of the University of Tennessee, Memphis, isrecruiting a scientist to participate in an establishedresearch program. The candidate must possess a Ph.D. inbiochemistry or cell biology and qualify for an appoint-ment at the ASSISTANTR level. Experi-ence in enzymology and molecular biology is essential.Specifically, the candidate must be knowledgeable inenzyme kinetics, the principles of proteinase biochemis-try, molecular doning, expression of recombinant pro-teins, and site-directed mutagenesis. Understanding ofthe principles ofinflammation and articular destruction isdesirable. Qualified applicants should submit their cur-riculum vitae to: Dr. Carlo Mainardi, Chief, MedicalService, Veterans Administr Medical Cen:tr, 1030Jeffrson Avenue, Memphis,TN 38104. The Unimsity ofTennessee, Menphis, is an Equal Emplcymt Opportunity!Tite IX/Seion 504/Affiative Action Employer.

COLUMBIA UNIVERSITY, Department of Psy-chology, anticipates making three faculty appointmentsat the ASSISTANT PROFESSOR level in the generalareas of developmental psychology, physiological psy-chology, and clinical/experimental psychopathology/health psychology. For all three positions, we seek recentPh.D.'s who have demonstrated exceptional promise forexcellence as a scholar-scientists, and who are outstand-ing teachers at both undergraduate and graduate levels.Applicants should submit curriculum vitae, copies ofrecent publications, and have three individuals familiarwith their training and abilities write letters of recom-mendation to: Personnel Search Committee, Depart-ment of Psychology, Schermerhorn Hall, Box 29,Columbia University, New York, NY 10027. Applica-tionsfirom members of minorities and women are encouraged.Columbia University is an AffirmativeAction/Equal Opportu-nity Employer.

14S2

POSITIONS OPEN

The Department of Biology at Hood College has twotenure-track ASSISTANT PROFESSOR positions, fora geneticist and a physiolopist, to begin August 1991.Each successful candidate will teach graduate and under-graduate courses. Hood College is a small liberal artscollege with a significant nontraditional-age student pop-ulation and graduate program. The bioloy departmentoffers undergraduate B.A. degrees in biology and envi-ronmental studies, an M.A. in Environmental Biology,and an M.S. in Biomedical Science. Qualified applicantsmust have a Ph.D. degree and a commitment to researchwith students. Postdoctoral and teaching experience aredesired. Hood Collge subscribes to the policy of hiring onlyU.S. citizens and lawfiuly authorized alien workers. We ac-tively encourage applications from women and memnbers ofminoritygroups. Send curriculum vitae, undergraduate andgraduate transcripts, statement of research interests, andthree letters of recommendation to: Dr. Ann Boyd,Department of Biology, Hood College, Frederick,MD 21701 by 1 December 1990. An Equal OpportunityEmployer.

COGNITIVE NEUROSCIENCE. The PsychologyDepartment at the University ofNorth Carolina (UNC)at Greensboro seeks applications for a tenure-track ap-pointment, at the ASSISTANT PROFESSOR level, inthe area of brain processes and cognitive functioning.Preferred applicants will have demonstrated a promise ofexcellence in research and commitment to teaching atgraduate and undergraduate levels. Ph.D.-granting de-partment has 24 faculty members with strong interdisci-plinary links. Salary is competitive. Copies of curriculumvitae, representative publications, and three letters ofreference should be sent to: Chair, Coni'tive Neuro-science Search, Department of Psychology, UNC-Greensboro, Greensboro, NC 27412. Applicationswill be accepted until 21 November 1990, or until theposition is filled. Applicationsfrom women and racial minor-ities are especially encouraged. An Affinnative Action/EqualOpportunity Employer.

CELL BIOLOGY/NEUROBIOLOGYA tenure-track position, at the ASSISTANT PRO-

FESSOR level, is available in the biology department atWesleyan University for a person who is incorporatingmodem structural and molecular techniques nto re-search addressing fundamental questions in neurobiol-ogy at the cellular level. The position is made possiblethrough a grant from the Howard Hughes MedicalInstitute. Applicants should have postdoctoral experienceand a demonstrated ability to develop an active researchprogram. Other responsibilities include directing theresearch of Ph.D. students and teaching at the under-graduate and graduate level. Please send curriculumvitae, a statement describing a future research program,and arrange that three letters ofrecommendation be sentby 15 November 1990 to: Chair, Search Committeefor Cell Biology/Neurobiology, Department of Biol-ogy, Wesleyan University, Middletown, CT 06457.Wesleyan is an Equal Opportunity/Afifnnative Action Institu-tion. We encourage applications firom minority candidates andwomen.

MOLECUL<AR GENETICISTThe search is re-opened for a tenure-track molecular

geneticist at the level ofASSISTANT PROFESSOR inthe Department of Biology, Carleton College, availableSeptember 1991. Teaching responsibilities include anupper level lecture/laboratory course in genetics; one inmolecular biology, immunology, microbiology, or areaof specialty; and participation in a team-taught introduc-tory course in energetics/genetics. Faculty are expected tomaintain a research program that encourages undergrad-uate participation and to actively seek external researchsupport. Start-up funds are available. The department ismost interested in persons with a commitment to teach-ing and research in the context of a liberal arts college.Ph.D. is necessary; postdoctoral experience is preferred.Under extraordinary circumstances appointment may bemade at a higher rank. Women and minority candidates arestrongly encouraged to apply. Send application, curriculumvitae, undergraduate and graduate transcripts, a state-ment of teachin philosophy, a summary of researchgoals, and three letters of recommendation to: G. J. C.Hili, Department of Biology, Carleton College,Northfleld, MN 55057-4025 by 15 October 1990.

Carleton College is an Equal Opportunity/Afirmative Ac-ton Employer.

SCIENCE, VOL. 249

POSITIONS OPEN

ASSISTANT PROFESSOR OF BIOLOGY. Ap-plications are invited for a tenure-track position to beginSeptember 1991. Preference will be given to candidateswith expertise in the molecular biology of prokaryotes.Teaching responsibilities will include genetics, at leastone advanced course in area of specialization, and partic-ipation in cell biology. Kalamazoo College is an excellentprivate liberal arts college that takes pride in the qualityof its science program. High-quality teaching is of veryhigh priority as is a research program that can engageundergraduates. Ph.D. required. Send letter of applica-tion, curriculum vitae, transcripts, statement of teachingand research interests, and three letters of recommenda-tion to: Dr. Carolyn R. Newton, Department ofBiology, Kalamazoo College, Kalamazoo, MI 49007.Review of applications will begin 1 November 1990.Affirmative Action/Equal Opportunity Employer. KalamazooCollege is committed to diversity and particularly encourageswomen and minorities to apply.

ASSISTANT PROFESSOR/BIOCHEMISTRYApplications and nominations are invited for the po-

sition of assistant professor (tenure track) in the Depart-ment of Chemistry at The University ofToledo. A Ph.D.in chemistry or biochemistry is required, and recentproductive postdoctoral experience is preferred. Thesuccessful candidate will be expected to establish an

independent externally supported research program inbiological chemistry. Applicants must also demonstrate acommitment to excellence in teaching chemistry andbiochemistry at the undergraduate and graduate levels.An application consisting of curriculum vitae, a publica-tions list, and a brief statement of research interestsshould be sent to: Professor Max 0. Funk, Depart-ment of Chemistry, University of Toledo, 2801 WestBancroft Street, Toledo, OH 43606. Applicantsshould also arrange for three letters of recommendationto be sent. Applications will be accepted until 1 Novem-ber 1990 or until a qualified candidate has been identi-fied. The University ofToledo is committed to Equal Oppor-tunity in employment through Afirmative Action.

TWO ASSISTANT PROFESSORSUniversity of South Florida. Two tenure-track posi-

tions beginning 15 August 1991. Ph.D. in geographyrequired. Candidates must have strong commitments toresearch, publications, and seeking external funding aswell as to undergraduate and graduate teaching. Pre-ferred specializations include physical (particularly digitalterrain modeling, geomorphology), human (especiallyurban or political), and methodological (quantitativeanalysis, remote sensing, GIS). Supporting regional spe-cialty highly desirable. Salary competitive.Apply to: Chair, Screening Committee, Depart-

ment of Geography, SOC 107, University of SouthFlorida, Tampa, FL 33620-8100.

Letters of application and a resume must be post-marked no later than 1 December 1990. 7he University ofSouth Florida is an Equal Opportunity/Afirmative ActionInstitution. Women and minorities are encouraged to apply.According to Florida law, applications and meetings regardingsame are open to the public.

ASSISTANT PROFESSOR, DIVISION OF BIO-LOGICAL SCIENCES. Candidates for this tenure-track faculty position should use prokaryotic or eukary-otic microbial systems to answer fundamental questionsin biology. Areas of strong research emphasis in thedivision include (i) cellular, molecular, genetic, anddevelopmental biology; (ii) population biology, ecology,and evolution; (iii) plant sciences; and (iv) neurobiologyphysiology, and behavior. We offer a highly competitivesalary, generous start-up package, modern research lab-oratory and support facilities, an active graduate programwith institutional support for students and postdoctoralassociates, and an interactive faculty. We are firmlycommitted to fostering ethnic and racial diversity in ourfaculty. Applications from women and minorities arestrongly encouraged. Applicants with a Ph.D., postdoc-toral research experience, and a demonstrated potentialfor creative research should send their curriculum vitae,reprints of publications, statement of future research andteaching interests, and names, addresses, and telephonenumbers of three references to: Dr. John David, Divi-sion of Biological Sciences, 110 Tucker Hall, Univer-sity of Missouri, Columbia, MO 65211. Applicationsmust be received by 1 February 1991 to receive fullconsideration.

21 SEPTEMBER 1990

POSITIONS OPEN

ASSISTANT PROFESSORSHIPS. The Depart-ment of Chemistry and Biochemistry of The Universityof Texas at Austin solicits applications for tenure-trackassistant professorships anticipated to be available Sep-tember 1991. Exceptional candidates in all areas ofchemistry/biochemistry will be considered. Candidateswho have demonstrated outstanding research ability andshow promise in teaching should forward curriculumvitae, short descriptions of research plans, and threeletters of reference by 1 November 1990 to: SearchCommittee, Department of Chemistry and Biochem-istry, The University of Texas at Austin, Austin, TX78712. Equal Opportunity/Afirmutive Aation Employer.

BIOCHEMISTRYASSISTANT PROFESSOR

Kent State University invites applications for thistenure-track position to begin August 1991 in the De-partment of Chemistry. Research specializations in allareas of modem biochemistry will be considered butthose involving the application of recombinant DNAmethods are preferred. Candidates should have a Ph.D.degree and postdoctoral training is desirable. Submitcurriculum vitae, undergraduate and graduate tran-scripts, description of research plans, and three letters ofrecommendation by 14 December 1990 to: Dr. RogerK. Gilpin, Chairman, Department of Chemistry,Kent State University, Kent, OH 44242. Equal Oppor-tunity/Affirmative Aton Employer.

ENVIRONMENTAL MICROBIOLOGISTTENURE TRACK

The Department of Biological Sciences, University ofCincinnati, has an opening for an environmental micro-biologist at the ASSISTANT PROFESSOR level start-ing 1 September 1991. The university, a comprehensivestate umversity, has an enrollment of about 36,000students. The department has 30 full-time faculty, and isexpanding in the areas of cellular and molecular biology,as well as environmental and evolutionary biology. Thereare about 70 graduate students, 65% are Ph.D. students.We seek a person who is studying the mechanisms ofbiodegradation of hazardous matenals using physiologi-cal and/or molecular techniques, as well as having astrong interest in bioremediation and/or fermentationtechnology. The successful candidate will be expected todevelop a vigorous, externally funded research program,train graduate students, and teach graduate as well asundergraduate courses in microbial physiology or ap-plied microbiology. The position requlres a Ph.D. andpostdoctoral experience is preferred. Applicants shouldsubmit a description of their research interests, futureresearch plans, and current curriculum vitae, and arrangeto have three letters of evaluation sent to: Dr. J. RobieVestal, Environmental Microbiology Search Commit-tee, Department of Biological Sciences, University ofCincinnati, Cincinnati, OH 45221-0006 by 1 No-vember 1990.

The University of Cincinnati is an Equal Opportunity!Afimative Action Employer.

ASSISTANT PROFESSORThe Division of Toxicology at the University of Ar-

kansas for Medical Sciences invites applicants for twotenure-track positions at the rank of assistant professor.Applicants must have a doctoral degree, postdoctoralexperience, and the ability to develop an independent

research program with extramural funding. Researchemphasis should be in toxicology or a closely relateddiscipline.The Division of Toxicology offers both the M.S. and

Ph.D. degrees. The division anticipates expanding tonine full-time faculty and will be housed in a newresearch building which is under construction. There area number of adjunct faculty at the nearby NationalCenter for Toxicological Research. The association be-tween the division and the NCIR offers the opportunityfor a variety of collaborative research efforts.

Qualified individuals are encouraged to forward theirresum6, list of publications, and the names and addressesofthree references to: Jack A. Hinson, Ph.D., Director,Division of Toxicology, Department of Pharmacol-ogy and Toxicology, oliege of Medicine, Universityof Arkansas for Medical Sciences, 4301 West Mark-ham Street, Little Rock, AR 72205, by 30 November1990. The University ofArkansasfor Medical Sciences is anEqual Opportunity Employer. Qualtfld women and minoritiesare encouraged to apply.

POSITIONS OPEN

ASSISTANT PROFESSOR, PHYSICSThe Smith College Physics Department invites appli-

cations for a 3-year tenure-track appointment in experi-mental physics at the assistant professor level, starting 1September 1991. The candidate should have a Ph.D., acommitment to undergraduate teaching, and should havea strong research program with projects which allowundergraduate involvement. Preference will be given topersons with postdoctoral experience. Funds are availableto start or extend a research project. Located in westernMassachusetts, Smith College is a leader in the educationof women and has an outstanding record in the numberof professional women physicists who are alumnae. TheFive ColleCoConsortium, comprised of Smith, Amherst,Mt. Holyoke, and Hampshire Colleges and the Univer-sity of Massachusetts, provides a rich intellectual andcuitural life for faculty and students as well as additionalcollegial opportunities in teaching and research. A cur-riculum vitae, statement of teaching and research inter-ests and experience, and three letters of reference shouldbe sent to: Professor Bruce Hawkins, Chair, Depart-ment of Physics, Clark Science Center, Smith Col-lege, Northampton, MA 01063. Preference will begiven to applications received before 15 November1990. Smith College is an Afifmative Action/Equal Oppor-tunity Institution. Minorities and women are encouraged toapply.

MOLECULAR MICROBIOLOGY POSMIIONSApplications are invited for two tenure-track positions

at the rank ofASSISTANT PROFESSOR in microbi-ology at the University of Arkansas. Successful candi-dates will have expertise in. the molecular aspects of eitherhumoral immunity, mutagenesis, anaerobic physiology,or microbial pathogenesis, and will teach B.S., M.S., andPh.D. microbiology majors. Candidates must have ademonstrated record ofresearch and a strong potential todevelop an externally funded research program. Applica-tions will be reviewed beginning 1 November 1990.Submit curriculum vitae, statement of teaching andresearch goals, and three letters ofreference to: Dr. D. E.Talburt, Department of Microbiology, University ofArkansas, Fayetteville, AR 72701. The Univerity ofArkansas is anAffirmativeAVctionual Opportunity Employer.

GROSS ANATOMISTDepartment of Surgery, University of California, San

Diego (UCSD). Tenure-track ASSISTANT PROFES-SOR position open to teach gross anatomy at the UCSDSchool of Medicine beginning 1 July 1991. This ismainly a teaching and research position,rwith someadministrative responsibilities. It requires interest andability to teach in the medical school core gross anatomycourse and to offer and participate in elective teaching.The candidate must have a Ph.D. in anatomy andresearch competence of a degree to allow independentproductivity and effective cooperative undertakings withothers. Send curriculum vitae and names of three aca-demic references to: N. A. Halasz, M.D., Professor andHead, Division of Anatomy, UCSD Medical Center,225 Dickinson Street, San Diego, CA 92103. Positioncloses 31 January 1991. Salary per published Universityof California scale. Equal Opportunity/Afirmative ActionEmployer.

ASSISTANT PROFESSORDEPARTMENT OF PHARMACOLOGY

AND TOXICOLOGYDARTMOUTH MEDICAL SCHOOL

Applications are invited from qualified individualspossessing a Ph.D. or M.D. degree and postdoctoralexperience. Although preference will be given to appli-cants with a funded research program in neuropharma-cology (e.g., signal transduction, molecular pharmacol-ogy or ion channels, developmental neurobiology,molecular aspects of neurodegenerative diseases), immu-notoxicology (e.g., immuno-radiotherapy), or moleculartoxicology, other areas of research will also be consid-ered. Responsibilities will include medical and graduateteaching in pharmacology and/or toxicology. Applicantsshould forward a complete curriculum vitae includingany teaching experience and grant support, an outline offuture research plans, and three letters of reference to:Chairman, Department of Pharmacology and Toxi-cology, Dartmouth Medical School, Hanover, NH03756. Deadline for receipt of these materials is 31October 1990. Dartmuth Collge is an Equal Opportunity!Affirnnative Action Employer.

PERSONNEL PLACEMENT I453

POSITIONS OPEN

ASSISTANT PROFESSOR/MEDICAL MICRO-BIOLOGY. Tenure-track position September 1991.Undergraduate teaching in medical microbiology/technology and a graduate course in area of expertise.Productive research, pursuit of outsidc research support,and supervision of M.S. and Ph.D. sudents reqr.Ph.D. required, postdoctoral experience preferred, teach-ing experience desirable. Send curriculum vitae, state-ment of research goals, transcripts, and three letters ofreference to: Medical Microbiology Search, Divisionof Biological Sciences, University of Montana, Mis-soula, MT 59812. Review of candidates begins 19November 1990. AnAinuativeAction/Equal OpportunityEmployer.

NEUROSCIENCE. University of California, SantaBarbara (UCSB). The Department of Psychology an-nounces a tenure-track position at the ASSISTANTPROFESSOR level in neuroscience, effective fall of1991. Responsibilities indude teaching at both under-graduate and graduate levels and supervision of studentsm research. Ph.D. required at time of appointment.Postdoctoral research experience and significant skills inIneuroedocrinology/endocrinology and behavior de-sired. Potential areas of interest within the broad field ofneuroendocrinology/endocrinology include neural con-trol of endocrine secretons, the efects of hormones onthe nervous system and/or physiology and behavior,hormones and development, or psychoneuroimmunol-ogy. Evidence of excellence in teaci and research isrequired. Salary and level depend on qualifications. Sub-mit curriculum vitae and reprints, and anrange for threeletters of recommendation to be sent to: BiopsychologvSearch Committee, Department of Psychology, Umn-versity of California, Santa Barbara, CA 933106. Applications must be received by 15 December 1990.UCSB is an Equal Opportunity/AjlrmativeAction Employr.ProofofU.S. citzuhip orel bilityfor U.S. employment wilbe required prior to employment (Immigration Rfornn andCqntml Act of 1986).

ASSISTANT PROFESSOR/BIOCHEMISTRYApplicants are invited for a tenure-track position of

assistant professor in biochemistry. Preference will begiven to applicants working in molecular/biology genet-iCS or protein structure-function relationship as deter-mined by in vitro mutagenesis or nudeic acid structure-function relationship. Despite these preferences,applications from individuals vaying other research in-terests and expertise are encouraged. Applicants, whoshould have the Ph.D. and postdoctoral experience inbiochemistry or a related field, will be expected todevelop an active, externally funded research program,and to participate in the undergraduate and graduateteaching programs of the department. Normal teachingassignments are a one-semester lecture or laboratorycourse per academic year. Applications should includecurriculum vitae, copies of publications, graduate andundergraduate transcripts, and a brief statement of cur-rent and future research interests. Three people, wellacquainted with the applicant's rmsearch and teachingability, should be asked to send letters of reference.Review of applications will begin in September 1990;interviews wilf be scheduled in late fall of 1990. Inquiriesand applications should be directed to: Dr. James B.Blair, Head, Biochemistry Departnt, 454 PS II,Oklahoma State University, Stillwater, OK 74078-0454. Telephone: 405-744-6189; FAX: 405-744-5339.

Oklahoma State Uniuveity is an Afllmnative AcoWEqualOportunity Employer.

ASSISTANT/ASSOCIATE PROFESSOR. TheDepartment of Botany and Plant Pathology, MichiganState University, is seeking applicants for a 12-month,tenure-track position in the area ofquantitative epidemi-ology, emphasizing modern concepts in population bi-ology, plant pathology, and mathematicalecologicalmodeling. Areas of interest indude soil or foliar host-parasite interactions, genetically transformed organisms,icide resistance, and model development and appli-

cation. Cooperative development of interdisciplinary re-

search and teaching programs will be encouraged. Re-

quirements indude a Ph.D. in plant pathology or cosely

related field. Send resume, summa of rarchtching

expenence, statement of career goals, and three letters of

reference to Dr. Patrick Hart, Detment of Botanyand Plant Pathology, Michigan State University, EastLansing, MI 48824. Closing date for applying is 1November 1990.

14-54

ASSISTANT OR ASSOCIATE PROFESSORSBIOCHEMISTRY/MOLECULAR BIOLOGYThe Department of Biochemistry at the University of

Mississippi Medical Center invites applicatons for twotenure-track positions. The department has strong re-search programs in eukryic gene orsnion andexpression, protein synthesis, ribosome biogenesis, neu-robiochemistry, nucleic acid biophysics, enzymology,and protein chemistry. Succsifl applicants are expectedto establish or have inde ent, high-quality, fundedrsearch programs and to participate in the training ofmedical, dental, and graduate students. Special consider-ation will be given to candidates in areas that comple-ment current research programs. Send curriculum vitae,an oudine of futu research plans, and the names ofthree rerences by 30 October 1990 to: Dr. MarkOlson, Chair, Detrtment ofBiochmistry, The Uni-versity of Mi ppMedical Center, 2500 NorthState Street, jackson, MS 39216-4505. Equal Oppor-tuniy Emplqyr, MFH/V.

VISITING ASSISTANT PROFESSORPosition involves teahing undaduate courses and

active participation in ongog rsear pro on theregulation of gene son. Ihe candidate will beresponsible fof establis independent researchprojects funded by amual sources. Applicants musthave a Ph.D. in biochemistry or related biological fields.Experience in teaching, research, and administrationrequired. Send curriculum vitae and names of threerrences by 15 October 1990 to: Dr. Leah Williams,Department of Biology, 200 Brooks Hall, West Vir-ginia University, Morgantown, WV 26506.

West Vginia Uniersity is an Ajinnatve ActioEqualOpportunity Emplor.CROP PRODUCTION PHYSIOLOGIST. Ten-

ure-track ASSISTANT, ASSOCIATE, OR FULLPROFESSOR; 80% rsearch, 20% taching. Develoment of independent basic research program in tephysiological processes that relate to crop production.T d with modem physiological andbiocheical techiques and % hs is essential aswell as proficiency in field applictions. Develop under-gradgraduaraduate course deain wit contemporary re-search approaches in crop physiology. Send r6sumi,transcripts, brief statement of future applied research,copies of seected publcations, and three Ietters of refer-ence by 1 Januar 1991 to: Dr Bian L ns, Depart-ment of Plant Sci Unives of Arizona, Tucson, AZ 85721. Equal Opportunity/Alnatve ActionEntloyer.

BIOLOGICAL OCEANOGRAPHYSCRIIPPS INSTITUTIONOF OCEANOGRAPHY

Applications are invited for ASSISTANT, ASSOCI-ATE or FULL PROFESSORIAL positions (tenuretrack/tenured); rank, level and salary commensurate withqualifications and expenence, based on University ofCalifornia pay scale. We are especially interested ininterdisciplinary oceanographer-biologists who have hadtraining and experience as occanographers; those whocan teach a kind of occanography that emphasizes themeasurement of the processes and events in the oceanitself as a means to understanding oceanic biology.Preference will be given to candidates whose researchemphasizes aspects ofthe interaction between populationbiology, sea water chemistry, and the physics of watermotion. Research topics which emphasize multiple scaleinteractions and can lenerized to gyre or global scaleissues are sought. Candidates will be expected to conductan active research program supported by extramuralfunds and to be involved ingraduate teaching and thesupervision ofgraduate students. Applicants must hold aPh.D. degree, or be advanced to candidacy, in an appro-pnate field, and have demonstrated excellence and inde-pendence in research. Assistant level candidates will beexpected to show evidence of their potential through apublication record appropriate for their experience andletters of recommendation; associate or full professorial-level candidates must show evidence of a strong researchrecord. Send letter ofapplication induding description ofresearch interests, list ofpublications, resume ofteachingexpeience, and names/addresses of five references to:Chair, Biological Oceanography Searc SIO Gradu-ate Department 0208, University of California, SanDieo, 9500 Giman Drive, La Jolla, CA 92093-0208. Closing date for applications is 15 November1990. An l Oppotnity/Afimnative Action Employer.

HARVARD MEDICAL SCHOOLCENTER FOR BLOOD RESEARCH

Applications are invited for ASSISTANT/ASSOCI-ATE PROFESSOR appointments in 1991 and 1992.We are seeking candidates with strong potential forinnovative research broadly relevant to the cell andmolecular biology of bloodces, the immune system,and associated diseases. Topics ofspecial interest indudecell-cell interactions, receptors and signaling pathways,cell activation, migration, and localization, the cytoskel-eton, hematopoiesis, inflammation, molecular genetics,and v'iroloD-.

andviwl. candidates will receive a faculty appoint-ment in an appropriate Department of Harvard MedicalSchool and will be expected to establish an outstandingresearch program. The position offers significant schol-arly and scientific resources and the opportunity to teachmedical and graduate students. The center will soonoccupy space m a new building on the medical schoolcampus. Applicants should submit curriculum vitae, re-trints of publications, a brief statement of present andhiture :h plans (no more than 500 words), and thenames of three ence to:

Prf Timothy Springer, Vice PresidentCenter fur Blood R ch, Box 367

800 H indig AvenueBoston, 02115

DEVELOPMENTAL NEUROBIOLOGISTUNIVERSITY OF PENNSYLVANIA

The David Mahoney Institute of Neurological Sci-ences (INS) of the University of Pennsylvania is recruit-inga Developmental Neurobiologist at the rank ofASSISTANT or ASSOCIATE PROFESSOR. We areinterested in people working on aspects of nervoussystem development at the molecular or cellular levels ininvertebrate or vertebrate systems. The INS has over 110members and has severl excellent laboratorics workingon molecular, cellular, and biochemical aspects of neuraldevelopment and regencration. Applicants should sendtheir curriculum vitae, a brief description of their re-search interests, and names and addresses of three refer-ences to: Robert L. Barchi, M.D., Ph.D., Develop-mental Search Committee, David Mahoney Instituteof Neurologi Sciences, 452 Medical EducationBuilding,'. niversity of Pennsylvania, Philadelphia,PA 191046074. Equal Opportunity/Afinnative ActionEmplayer.

CHAIRPERSONDEPARTMENT OF BIOLOGY

The University of Miami is searching for a highlyqualified individual for chairperson of the department.Candidates should have an active msearch program,demonstrated administrative skills, and an ability tofacilitate interaction among biologists with diverse inter-ests. The department includes 21 faculty and has anestablished graduate program leading to the Ph.D. Sev-eral biology-related units of the university afford oppor-tunities or collaboration. Candidates should submitcurriculum vitae and the names of four references to:Search Committee, Department of Biology, Univer-sity of Miami, P.O. Box 249118, Coral Gables, FL33124. Deadline for application is 1 November 1990 oruntil the position is filled. An Equal Opportunity/AJlr-native Action Employer.CHEMIST, SYNTHETIC ORGANIC. Responsi-

ble for design and synthesis of haptens and haptenprotein conjugates; synthesis of dyes, enzyme substrates,enzyme inhibitors, and protein and enzyme characteriza-tion. Candidates must have Ph.D. in organic chemistrywith at least 2 years of postdoctoral experience. Musthave cxtensive knowledge of synthetic organic chemistryand mechanisms ofenzyme inhibitor and receptor ligandinteractions. Must be familiar with HPLC, GLC, NMR,UV, and IR instrumentation. Must have expericnce inplanng and execution of multi-step synthesis. Salary:$44,512 per year. Job site: Palo Alto, California. Sendthis ad and your r6sumd to: Job Order #WS18172,P.O. Box 9560, Sacramento, CA 95823-0560, nolater than 6 October 1990.

PERSONNEL PLACEMENT ADS in ourline classified columns can be boxed for highervisibility. Call SCIENCE at 202-326-6555 fordetails.

SCIENCE, VOL. 249

POSITIONS OPEN POSITIONS OPEN

_ IIntramural Research Program

National Institute of Mental Health

The NIMH is accepting applica-tions for a senior neuroscientist withexperience and interest in applyingPET technology to the problem ofbrain function and structure andspecifically to the localization of brainfunction in relation to behavior,cognition and mental disorders.Applicants must hold a doctoral

degree (M.D. or Ph.D.) or equivalentin one of the clinical or basicneuroscience disciplines, e.g.,neuropsychiatry, psychiatry, neur-ology, neuropsychology, neuro-physiology, developmental neuro-biology, etc.The NIMH PET laboratory is

located in NIMH Intramural facilitiesat the Clinical Center of the NationalInstitutes of Health (NIH) inBethesda, Maryland, and theresearch is carried out with thetechnical support of the NIH NuclearMedicine Department. Twodedicated head scanners are sharedamong the three main user Institutesand substantial scanning time andresources are available. (NuclearMedicine operates the cyclotrons,PET scanners, and suppliesradiochemistry services for imagingresearch to all user Institutes.)Opportunities for collaboration inhuman studies abound, and facilitiesfor basic animal research are alsoavailable.Duties will include scientific

leadership, administration andcoordination of the NIMH PETprogram as well as the conduct ofinternationally-recognized research.Salary will be commensurate withthat of other NIMH investigators withequivalent qualifications andresponsibilities, ranging from$50,342 to $78,200 plus full Federalbenefits and, for M.D.'s only, relevantbonuses or special pay. U.S.citizenship required.Send C.V., bibliography, a

statement of future researchdirections, and the names of threereferences to:

Steven M. Paul, M.D.Director

Intramural Research ProgramNational Institute of

Mental HealthBuilding 10, Room 4N-224

9000 Rockville PikeBethesda, MD 20892

The NIMH is an Equal OpportunityEmployer.

THEDRALD DIRECTOR CNEM THE DERALD RUTTENBERG CANCER CENTER01WC,, THE MOUNT SINAI MEDICAL CENTER

Applications are invited for the position of Director of the recently establishedDerald Ruttenberg Cancer Center at The Mount Sinai Medical Center. Thisposition carries the status equivalent to a department chairman. Mount Sinai,with a tradition of excellence in clinical practice, teaching, and medicalresearch is reorganizing its cancer research activities into an institution-wideCancer Center.

We seek a leader trained as a physician, but whose professional prominencehas been achieved as a scientist. Applicants should have a very active researchprogram of major dimensions and an established international reputation forscholarly research. The Director will be expected to pursue his/her researchinterests and shape cancer research programs as a whole through new facultyrecruitment, the establishment of core research facilities, and by institution-wide educational programs. The candidate must have the vision and leadershipskills necessary to enhance the quality of, and interaction between, basicscience and clinical programs and integrate Cancer Center programs with thoseof the other Departments. The Mount Sinai Medical Center is committed to anexpansion of its clinical and basic science cancer programs and intends todevote extensive resources to this endeavor.

Applications or nominations should be addressed to: Dr. Robert A. Lazzarini,Chairman, Ruttenberg Cancer Center Search Committee, Brookdale Centerfor Molecular Biology, Box 1128A, Mount Sinai School of Medicine, NewYork, NY 10029-6547.

Mount Sinai is an Equal Opportunity/Affirmative Action Employer.

AAA_u uin*u** _

UITUNI UNI I I1Z

TheB1 bS innovative world leader in health careallenging career opportunity at our

echnical Center located in Murray Hill,New.- _*

andidate will join a group working witheptide hormones. This position

degree and two plus years of academic9 e rience in cell and molecular biology.

ExDIture techniques and basic recombi-logies is essential.

BOO offers a ca ging and stimulating scientificironment with the opportunity to

* ntists from many disciplines. We providean excellent compensation and benefits package. Forprompt, confidential consideration, please forward yourresume with salary requirements to: The BOC GroupTechnical Center, Human Resources Box E. M., 100Mountain Avenue, Murray Hill, NJ 07974. We are anequal opportunity employer M/F/HN.THE BOC GROUP_w M-,

Technical. Center

. m

DIRECTOR

BiotechnologyProgramCornell University invites applications for the position ofDirector of the Biotechnology Program. The Program, estab-lished in 1983, is funded by industry, state, federal and Cornellsources. The directorship is a half-time administrative ap-pointment. Additionally, the Director must be qualified to beappointed to a tenure-track position in a department consis-tent with his/her expertise. The Director should be interna-tionally recognized in an area related to biotechnology. Expe-rience in agricultural science is desirable, and demonstratedadministrative, management and leadership skills are essen-

tial. Continuation of an active research and teaching programis expected.The Director is the major spokesperson for biotechnology

at Cornell, with liaisons to faculty, external agencies, alumniand the public, overseeing a program with a current annualoperating budget of $4.5 million. In collaboration with theProgram's Scientific Administrative Board, the Director de-termines program goals and focus, funds research grants on

specific projects, is responsible for raisingand maintaining fundsfor the Program and interacts closelywith its current sponsors.A competitive salary with fringe benefits is offered. Appli-

cations, nominations and requests for further information willbe held confidential and should be directed to: Dr. NormanR. Scott, Vice President for Research and Advanced Studies,Cornell University, 314Day Hall, Ithaca, NY 14853. Telephone(607) 255-7200. Applications will be evaluated starting No-vember 1, 1990. The position will be available July 1, 1991.

Cornell University is an equal opportunity!affirmative action employer.

PROFESSOR OF GEOSCIENCESPURDUE UNIVERSITY

The School of Science at Purdue University has estab-lished a dedicated research facility for accelerator mass spec-

trometry (AMS) with the capability to analyze the followingcosmogenic radionuclides: 10Be, 14C, 26A1, 36C1, 4"Ca, and 1291.Funding is in place to support the operation of this facilityand to initiate research programs.

Purdue University's Department of Earth and Atmos-pheric Sciences seeks a distinguished faculty member at theassociate or full professor level with a particular interest inresearch using cosmogenic radioisotopes to study terrestrialprocesses and events. In addition, we encourage applica-tions for visiting professorships of 1- to 2-year duration. Asuccessful applicant will have a Ph.D. in the geosciences andan established record of excellence in basic scientific invest-igation of geoscience problems.

Please send vita to:

Professor Steven J. FritzDepartment of Earth and Atmospheric Sciences

Purdue UniversityWest Lafayette, Indiana 47907 USA

Screening will continue until the position is filled.

Purdue University is an affirmative action/equal opportunity employer.

MOLECULAR GENETICISTThe Department of Molecular Genetics of The Ohio State University isinitiating a search to fill three tenure track positions. It is anticipated thatone of these positions will be shared with the Ohio State BiotechnolgoyCenter. These positions may be filled at the AsIstant Potassor level or atmore advanced levels. We are particularly interested in applicants withresearch Interests In molecular genetic studies of major topics in molecu-lar, cell, developmental biology, or neurobiology using experimentalsystems such as yeast, Drosophila, Caenorhabditis, Mus, and humans.However, highly qualified applicants with other research specialties withinthe broader mandate of our unit will also be considered seriously. A highlycompetitive recruiting package is available, including an attractive (hardmoney) salary, generous laboratory space, substantial funds for equipmentpurchase and funds for initial operating expenses, independent of extramu-ral grant support. The Department and The Ohio State University are in theprocess of a major expansion in Molecular Biology and Biotechnology, anda substantial number of additional positions are anticipated in the future.Women and members of minority groups are enthusiastically encouragedto apply.

The Ohio State University is the flagship institution of the state's highereducation system. It is located in the state capital, Columbus, which is agrowing, yet highly affordable, metropolitan area of about 1.3 millionpeople. Columbus has been ranked by Newsweek as one of the country'sbest places to live and work.

Applications should include a detailed curriculum vitae, a description ofresearch experience, a statement of the nature of the planned independentresearch program, and the name, address and telephone number of each offour scientists who have agreed to serve as references. Applications will beaccepted until suitable candidates are hired but recruiting is scheduled tobegin in earnest by November 1990. Information about our Department canbe obtained by calling our offices at 614-292-8084.

Application materials should be sentto: Dr. Alan M. Lambowlit, Moleuelar

ssTHE BGnofesis8sb,Deparlimem Nelsen-THES lar Genetics, The Ohio SbtX University,OHIO 4o w. 121 Annue, Columbus, OhioSTATE The Ohio State University is an

Equal Opportunity/Affirmative ActionUNIVERSITY Employer.

GENSIA PHARMACEUTICALS, INC. is designingand developing drugs for treatment and diagnosis ofcardiovascular and CNS diseases. Continued growthhas created openings in Research and Development

RESEARCH - Candidates should have a BS/MS/PhDin pharmacology, biochemistry, chemistry, or relatedfield with skills or training in* enzyme purifications and drug screening* cell biology and platelet function* isolated organ and tissue pharmacology* in vivo pharmacology models* medicinal chemistry

DEVELOPMENT - Candidates should have a BSIMSin the life sciences and experience in* designing, implementing, monitorng and reporting

of clinical trials

Gensia offers competitive salary and benefits includingincentive stock options. For consideration, pleasesend a resume with cover letter to Human ResourcesDept., Gensia Pharmaceutcals, Inc., 11025 RoselleSt., San Diego, CA 92121-1204.

,.... ...

G E N S IAPHARMACEUTICALS, INC.

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At e NutraSweht Company,our widely-accepted technological breakthroughs allow us to

make today's world a better place for health-conscious consumers.With $869 million in sales success last year from our widely-

acclaimed product, NutraSweet and the introduction of ournewest breakthrough all-natural fat substitute, Simplesse,

* things keep getting better. The opportunity of a lifetime is now* available for top-notch professionals who are looking to make a

difference by making a good life even better.

RESEARCH SCIENTS r UAs a member of the fermentation research group, you will be respon-

sible for independenty conceiving and implementing scientificprojets for the development of new microbiological

and/or bioconversion processes. Areas of research willfocus primarily on the metabolism/physiology of

microorganisms and the development of processes toproduce novel fermentation products with food

is applications. Strong emphasis will be given to dairy startercultures and related microorganisms.

IN LIFE

BETTER.

A Ph.D. in Microbiology, Microbial Physiology or FoodScience as well as technical competence in the areas of

microbiology, microbial physiology and systematic bacter-iology ar required. 1-3 years of industrial or academicexperience in food microbiology/microbial physiology

would be a definite asset. An understanding of theregulatory aspects of food ingredients is preferred.

As a global leader committed to the development of improved consumer food choices throughthe application of advanced technologies, The NutraSweet Company offers an excellent com-pensation and benefits package plus the career, challenges, recognition and opportnities you

deserve in life. For immediate consideration, please forward your resume to: WayneTompkins, The NutraSweet Company, 601 Eat Kensnton Road, Mt. Prospect,

IL 60056. eoe m/f/h.

TheNutrSweet Company

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DirectorCenter for Drug Targeting

and AnalysisNortheastern University is establishing a new centerfor Drug Targeting and Analysis within the Collegeof Pharmacy and Alied Health Professions. TheUniversity is located in the center of the Bostonmedical and biotechnology research community andwill establish strong collaborative ties with diniciansand researchers in the area. Applications and nomi-nations are invited for a full time director of theCenter. This position also carries a senior facultyappointment in the College of Pharmacy and Alliedhealth Professions. The successful applicant shallhave a Ph.D. in pharmaceutics or in a relateddiscipline. An excellent record of scientific produc-tivity and grantamanship is essential. Experience inthe phannmaceutical industry is desirable. The direc-tor will be expected to develop a strong researchprogram with external support. He/she will haveresponsibility for the scientific and fiscal develop-ment of the center.

Applicants should submit a curriculum vitae and thenames of three references by November 30, 1990 to:

Mehdi Boroujerdi, Ph.D.Associate Dean and Director

of Graduate SchoolCollege of Pharmacy andAllied Health ProfessionNortheastem University

Boston, MA 02115Northeastern University is an equal opportunity/affimative action employer.

DERMATOLOGYPostdoctoral Research AssociatesMolecular Biologists/Biochemists

E t * offmann-La Roche, an established leader in the pharmaceutical indus-try, has two excellent opportunities in our Dermatologics Division, whichhas on-going programs related to acne, psoriasis, skin photoaging andhair growth.

PHOTODAMAGEYou will have the opportunity to apply methods of recombinant DNA technology toproblems involving the action of retinoids on the repair of photodamaged skin. Qualifi-cations include a Ph.D. in Biochemistry, Cell Biology or Pharmacology. Demonstratedexpertise in molecular biological techniques along with a working knowledge of thebiochemistry and physiology of skin desirable.

HAIR GROWTHYou will participate in studies on the regulation of keratinocyte growth and differentia-tion with the aim of understanding the regulation of hair growth at the biochemical lev-el. Qualifications include a Ph.D. in Biochemistry/Cell Biology. Experience in the areasof signal transduction and the regulation of cellular proliferation would be desirable,but not essential.Roche offers a research environment encouraging scientific growth. Interested individ-uals should send a curriculum-vitae indicating past, current and future research inter-ests, to: Mrs. Jane Jusinskl, Roche Dermatologics, Hoffmann-La Roche Inc., Nut-ley, New Jersey 07110. We are an equal opportunity employer.

* Hoffmann-La RocheWorking Today ForA HealthierTomorrow

FACULTY POSITIONDEPARTMENT OF PHYSICAL THERAPYFACULTY OF REHABILITATION MEDICINE

UNIVERSITY OF ALBERTAApplications are invited for two full-time tenure

track appointments, one of which is in the area ofgeriatrics, in the Department of Physical Therapy,University of Alberta, for July 1991. The University ofAlberta offers BSc and MSc degrees in PhysicalTherapy. Qualified candidates should possess a doc-toral degree. A physical therapy background would bean asset. Salary will be commensurate with qualifica-tions and experience (Assistant Professor: $36,910 -$53,374; Associate Professor: S45,694 - $67,658).Responsibilities include undergraduate and gradu-

ate teaching, research and scholarly work, and admin-istrative duties.

Qualified applicants should send a curriculum vitae,state their teaching and research interests, togetherwith the names of three referees to:

Prof. Sharon BrlntnellActIng Dean

Faculty of Rehabilitation Medicine3073 UAH Educaton & Development Centre

University of AlbertaEdmonton, Alberta

T6G 2B7In accordance with Canadian Immigration require-

ments, priority will be given to Canadian citizens andpermanent residents of Canada.

The University of Alberta is committed to theprinciple of equity in employment. The Universityencourages applications from aboriginal persons, dis-abled persons, members of visible minorities andwomen.

The deadline for receipt of applications is January31, 1991.

-..M.

POSITIONS OPEN

SMIT PROFESSOR OF CELL BIOLOGYCALIFORNIA INSTITUTE OF TECHNOLOGY

The Biology Division at the California Institute ofTechnology seeks to fill the new Howard Smit Chair inCell Biology. Cell biology is defined broadly, and encom-passes investigators taking biochemical, biophysical, ge-netic, immunological, morphological, and structural ap-proaches. Persons interested in this senior appointmentshould submit curriculum vitae to: Cell Biology SearchCommittee, c/o Paul H. Patterson, Biology Division,216-76, Caltech, Pasadena, CA 91125. Applicationsfiom women and minority candidates are especially encouraged.

Harvard University: The Department of Linguisticsinvites inquiries from persons qualified for appointmentto a F7ULL PROFESSORSHIP. The candidate shouldbe a theoretical linguist with a specialty in either phonol-ogy or syntax. Preference will be given to candidates withan interest in teaching in other related departments. Thepossibility of joint appointments exists for suitable can-didates. A curriculum vitae and the names of potentialreferees should be sent by 30 November 1990 to:Brendan Maher, University Hall 17, Harvard Univer-sity, Cambridge, MA 02138. Applications fom womenand minorities are especially wekome. Harvard University is anAffirmative Action/Equal Opportunity Employer.

CURATORSHIPMOLECULAR SYSTEMATICSAMERICAN MUSEUM OFNATURAL HISTORY

The American Museum of Natural History invitesapplicants for a tenure-track curatorial position in molec-ular systematics. The museum possesses suitable labora-tory facilities for DNA sequencing and electrophoresis.Applicants may be in any area of molecular systematics.

Research in molecular systematics will complement themuseum's existing research program which seeks both toanalyze phylogenetic relationships among fossil and re-cent taxa, and to elucidate aspects of the evolutionarvprocess. Successful candidate will participate as well in allcuratorial functions, including collections management,exhibition, and museum's administration. Position isavailable beginning 1 July 1991. A Ph.D. or equivalent isrequired. Rank and salary shall be determined basedupon qualifications and experience.

Applicants should forward (i) a statement of researchinterests and goals, (ii) curriculum vitae, (iii) completebibliography, and (iv) names, addresses, and telephonenumbers of at least three references familiar with theapplicant's qualifications and accomplishments. Applica-tions must be submitted by 15 October 1990 to:

Mr. Lee VilenskyPersonnel Department (S)

American Museum of Natural HistoryCentral Park West at 79th Street

New York, NY 10024An Equal Opportunity Employer.

The Delaware Museum of Natural History invitesapplications for an ASSISTANT CURATOR INMALACOLOGY. Responsibilities include departtmen-tal administration, conduction of collection-oriented re-search on molluscan systematics, participation in collec-tion management, and the museum's public programs.Applicants must have a doctorate or equivalent expen-ence. Curatorial experience desired. Position availableimmediately. Send r6sume, names of three references,brief statement of research goals, and reprints by 31October 1990 to: Chair, Search Committee, DelawareMuseum of Natural History, P.O. Box 3937, Wilm-ington, DE 19807.

ENVIRONMENTAL SPECIALISTSLimnologists, wetland and estuarine ecologists, envi-

ronmental scientists. The St. Johns River Water Manage-ment District has current and projected openings inapplied research and research management for surfacewater restoration and preservation programs. Startingsalaries are commensurate with exprience. Master's orPh.D. preferred in limnology, ecology, biology, or re-lated environmental science. SendrCsume identifyingsource of advertisement by 5 October 1990 to: St. JohnsRiver Water Management District, Office of Em-gloyee Relations, P.O. Box 1429, Palatka, FL2178-1429.An Equal Opportunity/AffirmativeAction Emplayevr, veter-

ans prefrence.

ASSOCIATE DEAN AND PROFESSOR OF BI-OLOGICAL SCIENCES. To chair the recently formedDivision of Biological Sciences. The division integratesthe areas of biochemistry, botany, microbiology, andzoology and offers B.S., M.S., and Ph.D. degrees in thesefields. The 40 faculty have an ongoing commitment toexcellence in undergraduate and graduate teaching, re-search, and service. Nominations are solicited. Applicantsmust have a doctoral degree in a biological science,successful research, administrative and teaching experi-ence, as well as the vision and leadership a ility todevelop and strenghen the division. Send curriculumvitae, statement of career goals, and names, addresses,and telephone numbers of five references to: AssociateDean Search Committee, Division of Biological Sci-ences, University of Montana, Missoula, MT 59812.Review begins 30 November 1990 and continues untilthe position is filled. The University of Montana islocated in Missoula, a cosmopolitan Rocky Mountaincommunity of 80,000. The city has often been singledout in national publications for its high quality of life.Abundant recreational opportunities in surroundingstate and national forests and nearby Glacier NationalPark complement a thriving intellectual atmosphere. AnAffirmative Action/Equal Opportunity Employer.

BIOENGINEERDIRECTOR, Orthopaedic Biomechanics Labora-

tory, University of Maryland. Ph.D. engineer experi-enced in biomechanics to develop on-site lab and workclosely with active clinical research program in spine andextremity reconstructive surgery.

Competitive salary and equipment funds with aca-demic appointments in both medical school and collegeof engineering. Please telephone: 301-328-8705 orwrite: Charles C. Edwards, M.D., Professor ofOrtho-paedic Surgery, University of Maryland Hospital,NGW52, Baltimore, MD 21201.

Equal Opportunity Employer, M/F/H/V.Minorities andfemales are encouraged to apply.DEPUTY DIRECTOR, OFFICE OFBIOLOGICAL PRODUCT REVIEW

$71,200 to $79,200In addition, physicians may be eligible for a retention

bonus of up to $20,000 per annum. Incumbent sharesresponsibility with the director for directing over 100professional and support staff in the evaluation andregulation of biological products presented for investiga-tional use or for market release. A plicants should havean M.D. degree from an approved medical school or adoctorate in a related biological or physical science;experience at the executive level in planning, directing,and evaluating broad scientific research or regulatoryprograms and activities which demonstrate the ability toeffectively coordinate and productively integrate the mul-tidisciplinary efforts of a scientific, professional, andtechnological workforce; administrative or managerialexperience at the executive level which demonstratesstrong leadership abilities in a scientific environment; andexperience which indicates the ability to implementEqual Employment Opportunity programs. Applicationfor Federal Employment, SF-171, is required and mustbe received by 18 October 1990. For additional infor-mation, contact: Mr. John Anderson, Division of Hu-man Resources Management, Food and Drug Ad-ministration, Room 4B-09, HFA-408, ParlawnBuilding, 5600 Fishers Lane, Rockville, MD 20857.Telephone: 301-443-1755.

An Equal Opportunity Employer.

FACULTY POSMONS IN CHEMISTRYThe Chemistry Department at the University of Cali-

fornia, Berkeley, solicits applications for positions asASSISTANT PROFESSOR of chemistry, beginningin the fall of 1991. Creative and energetic candidates inany area of chemistry who show exceptional promise forresearch and teaching are sought. Individuals selected forthese positions will be expected to establish an outstand-ing research program. Exceptional candidates with estab-lished programs may be considered for appointment withtenure as professor or associate professor. Candidatesshould send curriculum vitae, a proposed research pro-gram, and arrange to have three letters of recommenda-tion sent to: Chairman, Faculty Recruiting Comnmit-tee, Department of Chemistry, University ofCalifornia, Berkeley, CA 94720. The deadline forreceipt of applications is 1 December 1990. The Univer-sity ofCalto'rnia is an Equal Opportunity/Affirmative ActionEmployer.

BIOCHEMISTRY FACULTY POSITION.Chemistry Department, Pomona College. Tenure-trackposition at the ASSISTANT PROFESSOR level start-ing July 1991 to teach introductory and advancedcourses in biochemistry and to work closely with mem-bers of the Biology Department in the administration ofa joint program in biochemistry and molecular biology.The successful candidates must have a Ph.D. and acommitment to undergraduate teaching and research.There are excellent library, computing, and laboratoryfacilities including a H-P GC/MS system and a 300-MHzNMR spectrometer and ample space for research. Start-up funds for faculty research are available. PomonaCollege, the founding member of The Claremont Col-lege, is among the nation's most selective undergraduateinstitutions. To apply, submit a letter of interest, aresume, transcripts, a description of research interests,and three letters of reference by 29 October 1990 to:Professor Wayne E. Steinmentz, Chemistry Depart-ment, Pomona College, Claremont, CA 91711-6338. Pomona College is anAffirmativeAction/Equal Oppor-tunity Employer and especially invites applicationsfiom womenand minorites.

i4S8

LABORATORY DIRECTORENVIRONMENTAL MONITORING

SYSTEMS LABORATORYOFFICE OF MODELING,MONITORING SYSTEMS,

AND QUALITY ASSURANCELAS VEGAS, NEVADA

ES 401/801/1301$71,200 to $77,600

The U.S. Environmental Protection Agency(EPA) is seeking highly qualified candidates forthe position of laboratory director, Environmen-tal Monitoring Systems Laboratory, Las Vegas,Nevada (EMSL-LV), Office of Modeling, Mon-itoring Systems, and Quality Assurance (OM-MSQA). The EMSL-LV, a component of theOffice of Research and Development, is respon-sible for research and development supporting amajor segment of the agency's programs relatingto human and ecosystem exposure to environ-mental pollutants. The laboratory conducts re-search and development in the areas of: analyticalchemistry, immunochemistry, field monitoringmethods and design, ecological status andtrends, terrestrial ecology, integrated human ex-posure assessment, human biomarkers of expo-sure, remote sensing, geohydrology, and envi-ronmental radiation assessment.

Applicants for this Senior Executive Service(SES) position must have a bachelor's or higherdegree in life sciences, physical sciences, or engi-neering, or a field relating to the work of thelaboratory, and professional experience demon-strating leadership and technical competence inone ofthose fields. Applicants must also meet thetechnical and executive qualifications describedin the Vacancy Announcement. For a copy oftheVacancy Announcement, call or write:

Chaunta GladneyEnvironmental Protection Agency

Executive Resources andSpecial Programs Division

Room M3910 (Mail Code: PM-224)401 M Street, S.W. (Waterside Mall)

Washington, DC 20460Telephone: 202-382-3328

Applications must be postmarked by 6 Novem-ber 1990. EPA iS an Equal Opportunity Employer.

CIENCEcan publish YOUR LOGO with your one-

column line classified ad. No extra fee is assessed:you will be billed at our regular line rate for thenumber of lines the logo occupies. For details,call Classified Advertising: 202-326-6555.

SCIEENCEI, VOL. 249

POSITIONS OPEN POSITIONS OPEN

ScientistAt Genentech, our success in thebiotechnogo nustiy is a result ofsuperb personnel conbinedwith state-of-theart equipment in an eimron-ment where talent and innoaion areallowed to flourish. CurTenty, we areseeking a Sentist to supvse ourV'mus Tesfingand Rearch Lab inorder to ensure the scientific quality ofstudies perfomeDuties indude the imely initiation andcompletion ofceld onsafey studes, virus removal validatonstudies, compleion ofreports forindlusion in reglatory submissionsand the resolution ofcell substratesafetyissue.The sucessfu c atewill have aPh.D. in the Biological Sciences and aminimum of5 yes' aperience,including a post doc, in retrovirusresearch and cell biology. Experience

in HIVresearch, molecularvirology,knowledge ofGLP rglatons andsuperisr skills are deskable.Our commitment to the best is clearlyreflected in our exensive benefitspackage which indudes child carefacilities, fee health dub membesip,an employee stockpuhcase plan andfull paid medicat/dentWsioncoverage. For immediate consiraion,please send your resume to NancySymonds, Genentech, Inc., HumanResources Dept. MD, 460 Point SanBruno BIL, South San Francisco, CA94080. We civey support and promote

action and equal employ-ment opportunity. Women andminorities are encouraed to apply.

CHAIR, DEPARTMENTOF MICROBIOLOGY

Applications are Invited for the position of Professorand Head of the Department of Microbiology at theUniversity of Saskatchewan. The Head is expectedto pursue and build an active research program inmicrobial pathogenesis, microbial genetics, virologyor immunology. The Department Head has com-bined responsibility for the basic science departmentwithin the College of Medicine and for the ClinicalMicrobiology department in the Royal UniversityHospital. The department's service responsibilities inthe Royal University Hospital include bacteriology,serology, mycology, parasitology, mycobacterlology,and clinical immunology and HLA tissue typing. Thedepartment has teaching responsibilities in theheaith sciences (Medicine, Dentistry, OccupationalTherapy, Nursing, Pharmacy) and College of Artsand Sciences. The department offers a postgraduatedegree program at the M.Sc. and Ph.D. levels in thebasic science and at the Ph.D. level in ClinicalMicrobiology. The thirteen member facuity of theDepartment of Microbiology in the College of Medi-cine includes basic science microblologists, virolo-gists, immunologists, and medical microbiologists.Clinical infectious disease physicians in the Universi-ty Hospital are cross-appointed to the department.

Potential appiicants should send a curriculum vitae,a brief statement of current research interests andaddresses of three referees to:

I.M. McDonald, M.D., Dean of Medicine, Universityof Saskatchewan, B103 Health Sciences Building,Saskatoon, Saskatchewan, S7N OWO.

The closing date for applications is December 31,1990. In accordance with Canadian ImmigrationRegulations, preference will be given to Canadiansand landed immigrants.

FACULTY POSITIONDEVELOP LENTAL BIOLOGY

The Department of MolecularGenetics and Cell Biology invitesapplications for new faculty posi-tions in the field of developmentolbiology at the assistant professorlevel, although exceptionol candi-dotes at any level will be consi-dered. We are especially interestedin candidotes using developmentolgenetic approaches to understand-ing pottern formation and inter-cellular regulation, but the qualityof the research program and itsrelationship to existing strengthswill be the most important consi-derations. Complete applicationswith three letters of recommendationshould be sent by November 1,1990 to:

Dr. Anthony P. MahowaldChairman

Depament of Molecular Geneticsand Cell Biology

THE UNIVERSITYOF CHICAGO

920 E. 58th St.Chicago, IL 60637

An Affirmative Action Equal Opportunity Employer(Women and members of minority groups ore

strongly encouraged to apply.)

.M

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CELL BIOLOGY, MOLECULARBIOLOGY, PROTEIN PURIFICATION

Bone Development, Regeneration and RepairChiron Corporation, a leader in soft tissue growth factor and woundhealing research is expanding its growth and differentiation factorprogram in the area of bone morphogenesis.

We seek a motivated and dedicated scientist at the PhD. level toInvestigate the role ofvarious novel recombinantbone proteins in themorphogenesis and repair ofbone. Particularemphasiswilbe placedon bone repair models. The role ofbone morphogenetic proteins indiseases associated with abnormal bone resorption will also be tar-geted.

Applicants should have at least twoyears ofpost-doctoral experiencein bone cell biology or related fields. Also, candidates with somebackground knowledge of the molecular biology of bone would bepreferred. An ability to perform research independently must bedemonstrated by a record of publication In peer reviewed journals.

Two other positions exist at the B.S. or BA. lcvel for RescarchAssociates with an Interest in bone proteins at the molecular level.The first involves the molecular cloning, expression and post-trans-lational processing of novel bone-related proteins. The secondposition will involve the purification of recombinant bone proteinsproduced in heterologous microorganisms such as yeast, or Incultured mammalian cells. For these latter twvo postions, entxy levelapplications are encouraged.

Chiron Corporation, located in the San Francisco Bay Area, offers astimulating and challenging research environment, a competitivecompensation package and opportunities for professional advance-ment. Candidates please send C.V. and 2 references to Chiron Cor-poration. Human Resources Dept. - MB14849, 4580 Horton St.,Emeryvlle, CA 94608.

*CHIRONPCORPO RATIO0N

UNIVERSITY OF WISCONSIN-PARKSIDEASSISTANT PROFESSOR: MOLECULAR BIOLOGIST

The University of Wisconsin-Parkside Biological Sciences Department, aCenter of Excellence designated by the UW System Board of Regents, plans toadd one tenure-track faculty position for September 1991. An earlier startingdate is possible. This position offers opportunities for individuals seeking abalance of research and teaching.

Molecular Biologist: with proven competence in applying the techniques ofmolecular biology and biotechnology or immunology. The research program canbe in any eukaryotic system, preferably on regulation and/or architecture of agenome. Applicants must have a Ph.D. in one of the following fields; molecularbiology, immunology, genetics, developmental biology. Candidates with post-doctoral experience are preferred. The successful candidate should participate inthe undergraduate and graduate programs. Teaching assignments will includeupper level course(s) in the area of specialty, and an introductory course formajors or non-majors.

The University of Wisconsin-Parkside, located in the Chicago-Milwaukeeurban corridor, is a predominantly undergraduate institution. The 12-personbiology department offers an excellent undergraduate program with options/concentration in General Biology, Pre-Health Sciences and Molecular Biologyand a MS program in Applied Molecular Biology with emphasis on Biotechnolo-gy. Current research programs include molecular studies on plant hormones,plant derived insecticides, tabtoxin production and resistance, zinc fingerproteins in plants, and blood clotting factors; effects of electromagnetic fields ongene expression or wound repair; neuronal tissue regeneration; axenic growth ofHydra; circadian rhythms and pineal gland effects; lymphokines and tryptophancatabolism; cytochemistry of Acanthocephala; and enhancement of scienceinstruction. Collaborations are encouraged.

Applications, including a letter of interest, curriculum vitae, a list ofgraduate and undergraduate coursework, a brief summary of research goals,representative publications and 3 letters of reference should be sent to theaddress given below. Review of applications will begin on November 5, 1990and continue until the positions are filled. The Search Committee is interested inhearing from qualified women and members of minority groups. DR. S.P.DATTA, Chairperson, Biological Sciences Deparbnent, University of Wiscon-sin-Parkside, P.O. Box 2000, Kenosha, WI 53141, Telephone: 414-553-2469/553-2327. The University of Wisconsin-Parkside is an Equal OpportunitylAffirmative Action Employer.

AUSTRALIAN NATIONAL UNIVERSITY AUSTRALIARESEARCH FELLOW/POSTDOCTORAL FELLOWIN ECOSYSTEM DYNAMICS (one position),

RESEARCH SCHOOL OF BIOLOGICAL SCIENCES.

The Ecosystem Dynamics Group consists of about eight academic staff whowork collaboratively to investigate the processes of establishment, developmentand rehabilitation of particular ecosystems and to develop predictive models ofchanges in terrestrial ecosystems. Interests within the Group include communitytheory, modelling ecosystem processes, the dynamics of plant populations, fieldeco-physiology and plant-animal interactions. The Australian biota is the majorfocus and many of the Group's field projects are in eucalypt forests andwoodlands. The School is seeking to appoint a Research Fellow or PostdoctoralFellow to work within the Group. Candidates with demonstrated research skills inany of the areas of interest to the Group are encouraged to apply. In particular,candidates interested in testing theory via experimental studies in the field aresought. (Note applicants for the Postdoctoral Fellowships advertised in themiddle of this year will be automatically considered for this additional position.)For further information please contact Dr. Ian Noble or Dr. Marilyn Ball telephone(06) 249 4020, fax (06) 248 9995, Ecosystem Dynamics, RSBS, Box 475 GPO,Canberra 2601, Australia. Closing date: 5 October 1990. Ref: BS 30.8.1.SALARY: Research Fellow; A$33,163-A$43,096 p.a.; Postdoctoral Fellow Grade1 (fixed point); AS28,792-A$32,762 p.a. APPOINTMENT: Research Fellow up tothree years, possibility of extension to five years; Postdoctoral Fellow up to twoyears, possibility of extension to three years. APPLICATIONS should besubmitted in duplicate to the Registrar, The Australian National University, GPOBox 4, Canberra ACT 2601, Australia, quoting reference number and includingcurriculum vitae, list of publications and names of at least three referees. TheUniversity reserves the right not to make an appointment or to appoint byinvitation at any time. Further information is available from the Registrar.

THE UNIVERSITY IS AN EQUAL OPPORTUNITY EMPLOYER

Dy\ National Center for Food Safety /r and Technology

Staff Fellow Positions stXyAvailable Now- A unique opportunity for qualified scientists toplay an important role in a pioneering U.S. food scienceresearch effort in food safety. FDA is seeking Staff Fellows toconduct research in food biotechnology and fermentation tech-nology. Specific disciplines sought include:* Genetic Engineering * Microbial Genetics* Biotechnology * Biosensors* Food Microbiology * Protein Engineering* Fermentation Technology * Related Fields* Recombinant DNAThese positions are available at the National Center for FoodSafety and Technology, located at the IIT Moffett Campus inBedford Park, Illinois. Emphasis is on food safety researchconducted in cooperation with scientists from academia, othergovernment agencies, industry, and other segments of thescience community. Teaching responsibilities in a Food SafetyScience degree program at IIT may be part of the job. Candi-dates must have a master's degree, doctoral degree, or becertified by a university as meeting all requirements leading tosuch a degree in one of the listed disciplines or a closely relateddiscipline. Staff Fellowships are excepted appointments in theFederal Service. Candidates must be United States citizens orresident aliens eligible for naturalization within four years. Initialappointments will be for up to two years. Salary range ($29,891to $45,441) is based on qualifications and experience. A currentcurriculum vitae and bibliography should be sent to Dr. StevenGendel, Biotechnology Section, Food Engineering Branch,DHHS/PHS/FDA, National Center for Food Safety and Tech-nology, 6502 S. Archer Ave., Summit-Argo, IL 60501, not laterthan October 15, 1990.

CHIEFToxicology Branch, GM-14/15

The Developmental TherapeuticsProgram (DTP) of the Division ofCancer Treatment plays a major role inthe national effort to discover anddevelop agents for the treatment ofcancer and AIDS. The programoperates much like a pharmaceuticalcompany, with the major functionalelements found in such a company.The Toxicology Branch within DTPdevelops, implements, and analyzes,through a collaborative researchprogram, investigations on thetoxicological and pharmacologicalproperties of agents in in vivo and invitro experimental systems. Protocolstudies carried out under GoodLaboratory Practice Regulations yielddata which 1) establish an initial dosefor clinical trials; 2) evaluate organsystems adversely affected; 3) assessthe reversibility of the adverse effects;and 4) determine the scheduledependency of observed toxic effects.Information collected by the ToxicologyBranch is filed with the Food and DrugAdministration as the preclinical database for Investigational New DrugApplications which are required prior toinitiation of clinical trials.Pharmacology studies are designed todetermine the schedule dependency oforgan toxicity and to provideinformation to guide dose escalationprocedures and the initial design ofclinical trials regimens. These effortsare performed under contract and aremanaged by the professional staff ofthe Branch. The Branch Chief directsthis effort and coordinates the activitiesof the Branch with other preclinical andclinical components of the Division.

This position requires a Ph.D. (orequivalent) in toxicology, pharma-cology, or chemistry. Preference will begiven to candidates with extensiveexperience in drug development ordiscovery, especially as related tocancer or AIDS. Salary range is$50,342 to $76,982.

Candidates should send a copy of theirApplication for Federal Employment(SF-171), curriculum vitae andbibliography to:

National Institutes of HealthNational Cancer Institute

Personnel Management Branch9000 Rockville Pike

Executive Plaza South, Room T-43ATTN: JAC

Bethesda, Maryland 20892Applications must be received byOctober 31, 1990. For furthertechnical information, interested partiesmay call Dr. Saul Schepartz (301) 496-8720

U.S. Citizenship is RequiredNIH is an Equal Opportunity Employer

.

RESEARCH SCIENTISTMICROBIAL GENETICS

It Amgen has established itself as a leader in the discovery and development ofhuman therapeutic products through applications of molecular biology andbiotechnology. As a result of our on-going commitment to the development ofgene cloning technology, we have an immediate opportunity for a Research Scien-tist to contribute to programs in strain improvement, vector development andenhancement of heterologous gene expression.

Qualified candidates for this position must have a Ph.D. in Molecular Biology or anequivalent discipline and a minimum of 2 years' post-doctoral experience in thegenetics and molecular biology of E coli. Functional understanding of microbialphysiology is desirable.

Amgen's commitment to excellence in research has created a stimulating andchallenging environment conducive to innovation and creativity. As a company wehighly value our human resources and offer an excellent compensation andbenefits package including equity offerings. Our location is northwest of LosAngeles in an attractive community free of traffic congestion and other problemscommonly associated with the Los Angeles area.

If you have the required background and would like to contribute your expertise toour research efforts, please send a complete CV, in strictest confidence, to:

AMGEN, INC.Recruitment, Dept. #553Amgen CenterThousand OaksCA 91320-1789 A M A lIEqualOpportunityEmployer

AOPostdoctoral Research FellowshipsThe PARKE-DAVIS Pharmaceutical Research Division of Wamer-Lambert Companyhas initiated a mulitdisciplinary postdoctoral research program which will provide ex-citing opportunites to conduct basic studies in areas of potential therapeutic utility. Thefollowing fellowships are currently available:

Molecular Virology (Fellowship Z)The Fellow will be involved in investigating the regulation of HIV-encoded gene prod-ucts. Publication of research findings will be strongly encouraged. Applicants shouldhave an M.D. or Ph.D. with experience in recombinant DNA technology.

Endothelin Biology/Cardiovascular Biochemistry(Fellowship G)

The Fellow will conduct research on the cellular biology of endothelin as it relates to car-diovascular pathophysiology. Projects are focused on the characterization of endothelinreceptors and endothelin biosynthesis.-Applicants should have a Ph.D. in Biochemistry,Cell Biology or Pharmacology with experience in receptor/enzyme isolation and charac-terization. Knowledge of signal transduction mechanisms and cell culture is desirable.

Appointments are for one year, renewable for a second year. Compensation indudes$32,000 annual salary with relocation assistance and an attractive benefits package.Our modem, growing research facilities are located adjacent to the University of Mich-igan in an outstanding living and working environment

Send CV with three references to Jack Moyer, Human Resources, PARKE-DAVISPharmaceutical Research Division, Wamer-Lambert Company, 2800 PlymouthRoad, Ann Arbor, Ml 48105. Please indicate the fellowship you are applying for."Smoke-Free Work Environment"

"Equal Opportunity in Action"

PARKE-DAVIS_ ~~ADIVISION OF WA AE

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POSITIONS OPEN

FACULTY POSMONINORGANIC CHEMISTRY

UNIVERSITY OF MARYLANDCOLLEGE PARK (UMCP)

Inorganic chemists with a Ph.D. degree and outstand-ing credentials in any subdiscipline, including bioinor-ganic chemistry and solid-state chemistry, are encouragedto apply. This tenure-track position will probably befilled at the ASSISTANT PROFESSOR level, al-though the department is able to consider more seniorappointments. Applicants should submit a resume and ashort description of future research plans and shouldarrange for three letters of reference to be sent to:Professor George R. Helz, Inorganic Search Com-mittee, Department of Chemistry and Biochemistry,University of Maryland, College Park, MD 20742.Telephone: 301-454-4850 or 301-405-1797. For fullconsideration, all materials should be received by 1November 1990. UMCP is an Equal Opportunity/Afir-mative Action Employer.

FACULTY POSMON IN PHARMACOLOGYThe Department of Pharmacology, University ofTen-

nessee, Memphis, is seeking candidates for two tenure-track positions available 1 July 1991 and one tenure-trackposition available immediately at the rank of ASSIST-ANT OR ASSOCIATE PROFESSOR, dependent onexperience. Candidates should possess the Ph.D. degreein pharmacology, biochemistry, or a related discipline, orthe M.D. degree, and should have demonstrated excel-lence in research and a commitment to teaching. Appli-cants should have experience in application of modemconstructs of biochemistry, molecular biology, or cellbiology to problems of interest to pharmacology. Areasof particular interest include research in transmembranesignaling, tumor biology, cardiovascular pharmacology,and neurochemistry. Candidates will be expected toestablish their independent research programs, and par-ticipate in teaching of pharmacology to professional andgraduate students. Applicationsfrom minority candidates andwomen are strongly encouraged. Please submit curriculumvitae, the names ofthree references, and a briefstatementof future research plans to: Murray Heimberg, Ph.D.,M.D., Chairman, Department of Pharmacology, Uni-versity of Tennessee, Memphis, The Health ScenceCenter, Memphis, TN 38163. Search will continue untilpositions have been filled. The University of Tennessee,Memphis, is an Equal Employment Opportunity/Title DXISection 504/Aflnmnative Ation Employer.

FACULTY POSITIONS MOLECULAR ANDCELL BIOLOGY, PENNSYLVANIA STATE UNI-VERSITY. Applications are invited for faculty positionsat any rank in the Department of Molecular and CellBiology. We seek exceptional candidates whose researchinterests encompass any area of molecular and cell biol-ogy, but special consideration will be given to thosewhose research complements our areas of strength andfuture interest, to include (i) cellular and developmentalregulation in prokaryotic and eukaryotic systems, includ-ing gene regulation, signal transduction, receptors andgrowth factors; and (ii) macromolecular structure/func-tion relationships. Candidates with academic training inbacteriology and/or virology are especially encouraged toapply.

Candidates are expected to have exceptional researchcredentials and a commitment to teaching at the graduateand undergraduate levels in one or more of the disci-plines represented by the department. The department iscontemporary and vigorous and is responsible for re-search and teaching programs in biochemistry, microbi-ology, and molecular and cell biology. The departmenthas 30 research faculty and 80 graduate students. Wemaintain an aggressive research environment and encour-age cooperative and interdisciplinary projects within andoutside the department. Strong interactions exist withthe chemistry and biology departments, the College ofAgriculture, and the newly established BiotechnologyInstitute, with which joint appointments may be possi-ble. Applications will be reviewed starting 8 October1990 and continue until the positions are fled. Candi-dates should submit a resume including a statement ofresearch interests and goals and telephone numbers of atleast three references to: Chairman ofthe Search Com-mittee, Department of Molecular and Cell Biology,108S Althouse Laboratory, The Pennsylvania StateUniversity, University Park, PA 16802. AnA/lmnativeAction/Eqal Opportunity Emp-loyer. Womten and minoritiesare encouraged to apply.

I462

BIOCHEMISTRY, TENURE TRACK. DickinsonCollege, spring or fall of 1991. Ph.D. in biochemistry,with commitment to undergraduate chemical education.A research program with undergraduates is expected.Dickinson is a liberal arts college with ACS accreditation,six chenistry faculty, and new biochemistry teaching andresearch laboratories. Send resume, undergraduate andgraduate transcripts, statement of teaching philosophy,research plans, and three letters of recommendation to:Professor Willliam Schearer, Dickinson College, P.O.Box 1773, Carlisle, PA 17013-2896. Affimative Ac-tionEqual Opportunity Employer.

TENURE-TRACK BIOCHEMISTRY POSI-TION. Rank open, fall 1991. Candidates should have anexpertise in biochemistry, immunochemistry, and medi-cal biochemistry. Teaching may indude upper divisionlecture/laboratory courses and graduate courses. Candi-date is expected to establish a research program inimmunochemistry and be knowledgeable in techniquesusing protein antigen/antibody reactions, tissue/hybrid-oma cultures, and monoclonal antibodies. Further infor-mation and application forms can be obtained from:Chairman, Department of Chemistry, San Jose StateUniversit (SJSU), San Jose, CA 95192-0101. Inter-views will commence after 15 November 1990 andcontinue until the position is filled. Minoities and womenare strongly encouraged to apply. SJSU is an Equal Opportu-nity/AJIrmative Action Employer.

PENNSYLVANIA STATE UNIVERSITYBIOLOGY FACULTY POSMONS

The Department of Biology, Pennsylvania State Com-monwealth Educational System, imvites applications forfive tenure-track positions available August 1991.Berks Campus, Reading: vertebrate biologist posi-

tion requlres teadcing general biology, anatomy, andphysiology. McKeesport Campus, McKeesport: posi-tion requires teaching plant biology and genetics; micro-biology background desirable. Ogontz Campus, Abing-ton: position requires teac general biology; anatomyand physiology aexertise desirable. Wilkes-Barre Cam-pus, Wilkes-Barm: position requires teaching physiol-ogy, ecology, and general biofogy; a background ingenetics is desirable. Hazleton Campus, Hazleton: po-sition requires teaching anatomy, physiology, and gen-eral biology.

Candidates must have Ph.D. degree. Continuingscholarly activity, including research and publication, wibe required. Salary and rank commensurate with qualifi-cations. Application deadline: 1 November 1990 or untilsuitable applicants are found. Separate application mate-rials are required for each position. Send curriculumvitae, transcripts, and three letters ofreference to: SearchCommittee, Box G, 208 Mueller Laboratory, Univer-sity Park, PA 16802. AnAflfrinativeAction/Equal Oppor-tunity Employer. Women and minorities are encouraged toapply.

CRYSTALLOGRAPHERTENURE-TRACK FACULTY POSMIIONSOUTHERN ILLINOIS UNIVERSfTY

AT CARBONDALE (SIUC)The Department of Chemistry and Biochemistry in-

vites applications for a macromolecular x-ray crystallog-rapher at the ASSISTANT, ASSOCIATE, OR FULLPROFESSOR level. The 12-month appointment (withcross appointment in SIUC School of Medicine) is partofthe university's commitment to strengthen and expandits programs in molecular biology. The successful appli-cant will be expected to develop or have an activeresearch program in structural molecular biology andparticipate in teaching. All candidates must have anearned doctorate and postdoctoral experience. Rank willdepend on experience and qualifications. Generous start-up funda are available along with access to computingfacilities and a synchrotron source. Applicants shouldsend their curriculum vitae, a statement of research plans,two reprints, and have at least three letters of referencesent to: Dr. James Tyrrell, Chair, Search Committee,Chemistry and Biochemistry, Southern Illinois Uni-versity at Carbondale, Carbondale, IL 62901. Screen-ing of applicants will commence 22 October 1990 andcontinue until the position is filled. Minority andfemalescntists are encouraged to apply. SIUC is an Equal Opportu-nity/Affirrmative Action Employer.

More than 150,000 people paid to see your ad inSCIENCE. Classified Advertising Departnent tele-phone: 202-326-6555. FAX: 202-682-0816.

FACULTY POSMON INBIOCHEMISTRY/MOLECULAR BIOLOGY

UNIVERSITY OF CALIEFORNIAAT SANTA BARBARA

The Biochemistry and Molecular Biology Programand the Department of Biological Sciences invite appli-cations for a tenure-track teaching/research position atthe ASSISTANT PROFESSOR leve. Potential areasof interest in eukaryotic cell microbiology include, butare not exclusive to oncogenes, retroviruses, receptors,and signal transduction mechanisms. Applicants musthave a Ph.D. degree and postdoctoral training. Thesuccessfil applicant will be expected to conduct a vigor-ous independent research program and to contribute toteaching in molecular cell biology and biochemistry atthe graduate and undergraduate levels. The position iseffective 1 July 1991. Applicants should submit theircurriculum vitae, selected reprints, and a briefdescriptionof previous and anticipated research by 1 December1990O. Applicants should also arrange to have at leastthree letters of reference sent to: Director, c/o FrancesMcCutchon, Interdepartmental Biochemistry/Molec-ular Biology Program, Department of Biological Sci-ences, Umversity of Calomia, Santa Barbara, CA93106.

FACULTY POSMIIONS IN CELL,MOLECULAR, AND STRUCTURAL BIOLOGYApplications are invited for tenure-track positions in

the newly formed Department of Cell, Mo ecar, andStructural Biology at Nothwestem University MedicalSchool. Positions are available at all levels from ASSIST-ANT TO FULL PROFESSOR. Applicants must havea Ph.D., M.D., or equivalent degree, with researchexperience in cell, molecular, or structural biology. Ap-plicants will be screened with respect to their ability tocarry on vigorous independent research and to partici-pate in the various teaching programs administered bythe department. Send complete curriculum vitae and abrief description of research interests to: Dr. Robert D.Goldman, Chairman, Department of Cell, Molecular,and Strctural Biology, Northwestern UniversityMedical School, 303 East Chicago Avenue, Chicago,IL 60611.

Northwestern University is an Equal Opportunity/A/fir-mative Action Educator and Employer and invites applicationsfiom all qual#Wed individuals. Applications from women andminorities are especially sought.

FACULTY POSMIIONSIN MOLECULAR BIOPHYSICS

The Department ofBiophysics and Biophysical Chem-istry at The Johns Hopkins University School of Medi-cine invites applications for several faculty positions inthe newly funded Markey Center for MacromolecularStructure and Function. We anticipate that the appoint-ments will be at the ASSIST PROFESSOR levelalthough more senior appointment may be possible forhighly qualified individuals. Areas of particular currentinterest are macromolecular structure determination byx-ray diffraction or NMR methods but appointments arealso expected in other areas of molcuar biophysics.Send curriculum vitae, a description of research interests,and arrange for three letters of recommendation to besent, by 15 November 1990 to: Dr. Jeremy M. Berg,Department of Biophysics and Biophysical Chemis-try, The Johns Hopkins University School of Medi-cine, 725 North Wolfe Street, BaltimoreMD 21205-2185. FAX: 301-955-0637.AnAfilrnativeAction/EqualOpportunity Employer.

MOLECULAR BIOLOGIST. The Department ofBiology, The University of Alabama, is seeking appli-cants with research interests in any area related to themolecular biology of gene expression for a tenure-trackfaculty position. The appointment can be made at anylevel. The successfil candidate will be a participant in theMolecular Biology Program within the department andwill have access to excellent instrument facilities andgenerous start-up funds. Applicants should submit cur-riculum vitae, statement of research interests, reprints ofrecent publications, and the names and addresses ofthreereferences to: Dr. Janis O'Donnell, Chair, ScarchCommittee, Department of Biology, The Universityof Alabama, Box 870344, Tuscaloosa, AL 35487-0344. Review of applications will begin 31 October1990. The Univeity ofAlabama is an Equal Opportunity/Affimsative Action Employer.

SCIENCE, VOL. 249

POSITIONS OPEN POSITIONS OPEN

Department of Health and Human ServicesPublic Health Service . National Institutes of Health

National Institute on Deafness andOther Communication Disorders

DIRECTORDIVISION OF INTRAMURAL RESEARCH

Opening Dae: August 17, 1990 Cbsing Date: October31, 1990(All applications must be post-marked by the closing date.)

The National Institute on Deafness and OtherCommunication Disorders (NIDCD) is recruiting for theposition of Director, Division of Intramural Research(DIR). The Director, DIR, directs a program of multi-disciplinary fundamental and clinical research for theNIDCD. The Director, DIR, serves as the principaladvisor to the Institute Director on biomedical andscientific affairs involving the intramural researchprograms conducted by basic and clinical researchInvestigators in the field of deafness and othercommunication disorders. The Director develops andrecommends policies for the execution of the intramuralresearch programs, determines their ongoingeffectiveness, and recommends or develops new orrevised direct research programs. In collaboration withsenior officials, the Director, DIR, participates in thedesign and implementation of overall Institutemanagement policies including program planning,budget formulation, and resource allocation. TheDivision of Intramural Research has an FY 1990 budgetof $4.3 million and a current FTE ceiling of 24.

This is a Civil Service position in the Senior ExecutiveService (SES), with base salary currently from $71,200to $79,200 per year depending on qualifications. SESmembers are eligible for various bonuses and awards,and physicians are eligible for a comparabilityallowance of up to $20,000 per year, although totalcompensation cannot exceed the rate for ExecutiveLevel I (currently $107,300 per year). (Alternatively,applicants may be eligible for appointment in theCommissioned Corps of the U.S. Public HealthService.) The SES individual selected, if not presentlyin the Senior Executive Service, must serve a one-yearprobationary period.

Further information about the position and qualificationrequirements may be obtained by contacting Ms.Christine A. Clements at (301) 402-0508 (Voice or TDD)or TDD (301) 402-1134. An Application for FederalEmployment (SF-171) along with a Curriculum Vitaeand Bibliography should be submitted to:

Ms. Christine A. ClementsPersonnel Management Specialist P' IN6>National Institutes of HealthNational Institute on Deafness and nOther Communication Disorders ZBuilding 31, Room B2C05 OE ,9000 Rockville PikeBethesda, Maryland 20892

Additional Information may be obtained from:Dr. Edward Korn, Chairperson, NIDCD SearchCommittee for Director, Division of Intramural Research,NIDCD, National Institutes of Health, Building 10, Room7N214, 9000 Rockville Pike, Bethesda, Maryland20892. (301) 496-2116.

NIH is an Equal Opportunity Employer Ii

FLAVOUR CHEMIST

RESEARCH

SCIENTIST/SENIOR

RESEARCH SCIENTISTA$32,471 -$39,724/A$41,067-$47,070CSIRO DIVISION OF FOOD PROCESSING DAIRYRESEARCH LABORATORY HIGHETT, VICTORIA,AUSTRALIAFIELD: Flavour Chemistry.THE PROGRAM: The Dairy Research Laboratory, aLaboratory within the Division of Food Processing,conducts research aimed at improving the quality of dairyproducts, adding value to dairy products by developing newor improved manufacturing processes and by developingnew products and finding new uses for existing products.Working in association with the dairy industry, theLaboratory undertakes pure and applied research and has areputation for successful development and transfer oftechnology to the commercial sector. The Laboratory hasan active Flavour Group which has investigated bothdesirable and undesirable flavours of dairy products. In thecourse of this work many new techniques have beendevised for the isolation, identification and quantification offlavour compounds. Equipment in the Laboratory includes aFinnigan 1020 gas chromatograph/mass spectrometer/datasystem, several gas chromatographs, HPLC and lowpressure distillation systems.

The position offers to the right scientist an opportunity todevelop a key role in the laboratory through a combinationof scientific excellence and the solution of industrialproblems.

DUTIES: The appointee will be required to develop anexpertise in the various techniques of flavour chemistrycurrently used in the Laboratory, to undertake research intothe desirable flavour of Cheddar cheese and to consult withIndustry in connection with problems in the flavour of food.

QUALIFICATIONS: A PhD degree or equivalentqualification in Chemistry, including extensive experience inthe analysis of trace quantities of organic materialsalthough not necessarily flavour volatiles. Leadershipqualities, research skills and the ability to liaise effectivelywith industr-y are essential.

CONDITIONS: Appointment will be on an indefinite basiswith Australian Government Superannuation benefits.

MORE INFORMATION: Prospective applicants are invited totelephdne Mrs. Gerda Urbach on (613) 556-2211 or write tothe address below for further information. A copy of thedetailed job description and selection criteria can beobtained from Mark Kenward on (613) 556-2211. Facsimileservice is available on (613) 532-0003.

APPLICATIONS: These should be submitted by 19 October1990 and should quote reference number GURS01.Applications should relate to the Selection Criteria andprovide details of relevant personal particulars, includingqualificationsand experience and thenames and contactaddresses of at leasttwo professionalreferees. They shouldbe addressed to:

The Head ofLaboratory,CSIRO Division ofFood Processing,Dairy ResearchLaboratory,

IP.O. Box2, C S I ROHighett, Victoria, 3190,

AU T R AL A

Australia.

CSIRO IS AN EQUAL OPPORTUNITY EMPLOYERCSIRO PROMOTES A SMOKE-FREE ENVIRONMENT 2LI I

POSITIONS OPEN

BIOCHEMISTRY/MOLECULAR BIOLOGYTEXAS A&M UNIVERSITY

The Department of Biochemistry and Biophysics isseeking applications for FACULTY POSTIIONS.These are 12-month, tenure-track positions to be filled bySeptember 1991. Academic rank is open and dependentupon experience and qualifications. Outstanding individ-uals havng research interests dealing with the molecularaspects of regulation, structure, mechanism, or functionin microbial, animal, or plant systems are sought. Inaddition to research, participation in the department'sundergraduate and graduate teaching programs will berequlred. A Ph.D. in either biochemsstry or a relatedfe plus appropriate postdoctoral experience, is re-quired.

Applicants should send curriculum vitae, list of publi-cations, a brief description of current and future researchdirections, and have three letters ofreference sent to: Dr.Robert D. Welis, Department of Biochemistry andBiophysics, Texas A&M University, College Station,TX 77843-2128.

The Texas A&M University System is an AffirmativeAction/Equal Opportunity Employer.

MOLECULAR GENETICISTThe Department of Psychiatry of the Mount Sinai

School of Medicine is seeking a well-trained molecularbiologist interested in applying techniques of molecularbiology to the investigation o the molecular genetics ofschizophrenia.

Applicants should have a Ph.D. and/or M.D. andrelevant experience in PCR techniques, RFLP analysis,DNA cloning, and sequencing. The successfdl candidatewill work closely with a multidisciplinary team ofmolec-ular biologists, geneticists, psychiatrists, and clinical psy-chologists to determine linkage of various genetic mark-ers to schizophrenia using well-characterized families.Substantial laboratory space and facilities have beenallocated for this project. Oppornanities for independentresearch within the project are also available.

Salary and rank will depend on qualifications andexperience. Applicants should submit curriculum vitaeand three letters of reference to: Larry D. Altstiel,M.D., Ph.D., Department of Psychiatry, The MountSinai School ofMedicine, One Gustave L. Levy Place,New York, NY 10029-6574.The Mount Sinai School ofMedicine is an Equal Opportu-

nity/Affirmative Action Employer. Women and minorities areencouraged to apply

NEUROENDOCRINOLOGISTThe Neuroscience Unit at the Douglas Hospital Re-

search Center is seeking a Ph.D., neuroendocrinologistwith (i) a developed research program related to matu-rational changes in endocrine function, (ii) a backgroundin molecular and cellular endocrinology, and (iii) anemphasis on hypothalamic-pituitary-adrenal function.The position is potentially tenure track, depending uponthe strengths and performance ofthe individual, who willbe expected to develop a strong, independent researchprogram, acquire funding support, and participate ingraduate student training. There are minimal teacg oradministrative responsibilities. The Douglas HospitalResearch Center is associated with McGill University andcurrently consists of eight faculty members with researchinterests ranging from molecular biology to psychobiol-ogy, with a strong record of collaboration, as well as anumber ofgraduate and postdoctoral fellows. Send letterof interest, curriculum vitae, the names of three or morereferences, and any inquiries to: Michael J. Meaney,Douglas Hospital Research Center, Department ofPsychiatry, McGill University, 6875 Boulevard La-Salle, Montnial, Qu6bec H4H 1R3, Canada.

In accordance with Canadian immigration requirements, pri-ority will begiven to Canadian citizens andpennanent residentspossessing the required training and research background.

POSTDOCTORAL POSMON. Available imme-diately to study neuronal nicotinic receptors. Studies willfocus on characterization of transiently expressed acetyl-choline receptors in cos cells. Ph.D. and/or M.D. andexperience in cell culturing is required. Experience inbasic molecular biology techniques and/or patch clamp-ing is desirable. Send curriculum vitae and names ofthreereferences to: Dr. Barbara A. Dodson, Department ofAnesthesia, Box 0648, or Dr. John Forsayeth, De-partment of Physiology, Box 0444, University ofCalifornia, San Francisco, San Francisco, CA 94143.

I464

ORGANIC CHEMISTENZYME INHIBITORS

A staff position requiring a Ph.D. in organic chemistryto join the chemistry group of a leading neurosciencecompany. The investigators will develop both peptideand non-peptide enzyme inhibitors for the treatment ofneurodegenerative diseases. Broad experience in organicsynthesis is necessary. Experience with molecular model-ling iS desirable.

Cephalon, located near suburban Philadelphia, offersan outstanding collaborative research environment, anexcellent compensation package, and a newly constructedlaboratory facility. Send resume and the names of threereferences to: Dr. James Kauer, Cephalon, Inc., 145Brandywine Parkway, West Chester, PA 19380.

The Department of Obstetrics and Gynecology at theUniversity of Tennessee College of Medicine is activelyrecruiting a full-time PERINATOLOGIST for its Di-vision of Maternal/Fetal Medicine. The teaching hospitalserves as the Tertiary Care Center for 80 counties in WestTennessee, East Arkansas, North Mississippi, SouthernMissouri, and a part of Kentucky; an area with approx-imately 40,000 deliveries per year. About 50% of thepregnancies delivered at the center are high-risk pregnan-cies. Perinatal services each year indude over 20,000outpatient visits, 7,800 deliveries, and over 1,400 pa-tients seen in reproductive genetics. Excellent opportu-nity to participate in teactng in a Board-approvedfellowship program and collaborate in ongoing researchin clinical perinatology, critical care in obstetrics, ultra-sound, and prenatal diagnosis. Board-eligibility/Board-certification in mat mecine is required. Inter-ested candidates should send curriculum vitae to: BahaM. Sibai, M.D., Division ofMaternalFetal Medicine,University of Tennessee, Memphis, 853 JeffersonAvenue, Room E-102, Memphis, TN 38103. Tele-phone: 901-528-5660.The University of Tennessee, Memphis, is an Equal Em-

ployment Opportunity/Afirmative ActiontTitle IX/Section504 Employer.

HARVARD MEDICAL SCHOOLPOSTDOCTORAL POSMON

Position available immediately to study the role ofcyclic GMP in signal transduction and cellular function.Research involves role ofcGMP in platelet and smoothmusdce cell signaling pathways, and isolation and charac-terization ot unique substrates for cGMP-dependentprotein kinase. Ph.D. in molecular biology with addi-tional expertise in protein biochemistry preferred. Abilityto work independently necessary. Send curriculum vitaeand names/tekephone numbers of three references to: Dr.Michael E. Mendelsohn, Department ofMedicine, 75Francis Street, Boston, MA 02115.

An Equal Opportunity Employer.

POSTDOCTORAL RESEARCH POSMIIONIN TROPICAL PALYNOLOGYSMITHSONIAN TROPICALRESEARCH INSTITUTE

The Smithsonian Tropical Research Institute (STRI)invites applicants for a 3-year postdoctoral position inpaleoecological palynology to start in July 1991. Theinstitute is a bureau of the Smithsonian Institution andhas headquarters in the Republic of Panama. The Centerfor Paleoecology at STRI is documenting the environ-mental and ecological history of the region, includinganthropogenic ifuences on ecosystems. Investigatorsparticipating in the work of the center include PaulColinvaux, Richard Cooke, Jeremy Jackson, and DoloresPiperno. Annual stipend starting at $25,000 plus travel,benefits, and research support. Screening will begin on 1

January 1991 and continue until the position is filled.Applicants should include statement of research interests,curriculum vitae, reprints, and names, addresses, andtelephone numbers of three references. Send to:

Palynology Search CommitteeSmithsonian Tropical Research Institute

APO Miami 34002-0011The Smidtsonian Institution is an Equal Opportunity/Affir-

mativeAction Employer, and appointment can be made withoutregard to nationality.

SCIENCE recruitment ads reach thousands of scien-tists in all disciplines, worldwide. Classified Advcrtisingtelephonc: 202-326-6555. FAX: 202-682-0816.

POSTDOCTORAL POSMONS. To study neuro-trophic factors (NGF and NGF-related). Transcription,mRNA stability, transgenic mice, cell lines, primarycultures, in vitro assays, computer modeling. Outstand-ing new laboratories. Dedicated core facilities. Strongintcrdepartmental interactions. Send curriculum vitacand names of three references to: Gcrhard Heinrich,M.D., Biomolecular Medicine, Evans 600, UniversityHospital, Boston University Medical Center, 88 EastNcwton Street, Boston, MA 02118.

POSTDOCTORAL POSiIONS. Several posi-tions are available immediately to study various aspects ofgene expression induding: thyroid hormone receptor-I)NA interactions and hormonal regulation and cell-specific expression of renin, growth hormone, and pro-lactin genes. Experience in cell culture, transfection,general recombinant DNA and protein-DNA interac-tions is advantageous, however highly motivated individ-uals with badcgrounds in related areas are encouraged toapply. Send application, curriculum vitae, and the namesand telephone numbers oftwo references to: Dr. DanielF. Catanzaro, Department of Physiology and Bio-physics, Cornell University Medical College, 1300York Avenue, New York, NY 10021. Telephone:212-746-6497; FAX: 212-746-8690.

POSMIION INMOLECULAR BIOLOGY/IMMUNOLOGY

Postdoctoral position available from November 1990to work on one of the following topics: (i) expressionand protein engineering of soluble T cell receptors inEscherichia coli, (ii) genetic manipulation of antibodyfragments and the construction of novel immunotoxinsusing Escherichia coli as an expression host. For a relevantreference, please see Ward et al., Nature 341, 544-546(1989). For the postdoctoral position, expertise in mo-lecular biology expression of recombinant proteins and/or immunology is desirable, but not essential. Particularemphasis will be placed on the development of immuno-therapeutic strategies for cancer and autoimmunity.

Applications, including curriculum vitae and thenames of two referees, should be sent to: Dr. E. SallyWard, Cancer Immunobiology Center, University ofTcxas Southwestern Medical Center, 5323 HarryHines Boulevard, Dallas, TX 75235-8576.AnAffrmative ActiorEqual Opportunity Employer.

POSTDOCTORAL POSMON. Two positions forPh.D. in neuroscience or related discipline to participatein studies of the pharmacology of brainstem and spinalcord pain pathways. First position (available immedi-ately) to study involvement of GABAA/benzodiazepine/barbiturate receptor complex and GABAB receptors.Second position (availablc 1 February 1990) to studyrole ofopioid receptor subtypes. Experience with behav-ioral testing, microinjection, or stimulation techniquespreferred. Neuroanatomical or neurochemical expertisealso desirable. Send curriculum vitae, two-page descrip-tion of research interests, and names of three referencesto: Donna L. Hammond, Ph.D., Department of An-esthesiology and Critical Care, The University ofChicago, 5841 South Maryland Avenue, Box 428,Chicago, IL 60637.

An Affirmtive Ation/Equal Opportunity Employer.

POSTDOCTORAL POSMIIONENDOCRINE TOXICOLOGY

Department of Pharmacology and Toxicology, Mich-igan State University. A Ph.D. scientist is needed toparticipate in research directed toward understanding thebiochemical mechanisms by which certain chemicals in-hibit the synthesis of insulin in animal and/or cellularsystems. A strong background in biochemistry, pharma-cology, or other disciplnes in which molecular biologyknowledge and cxperience have been gained is desirabre.Measurement ofmRNA levels by Northern analysis andother methods of investigation into the processes con-nected with synthesis of polypeptide hormones will bepart of the research program. Funds are available for a 1-or 2-year commitment. Contact:

Lawrence J. Fischer, Ph.D.Institute for Environmental Toxicology

C-231 Holden HallMichigan State UniversityEast Lansing, MI 48824

Telephone: 517-353-6469

SCIENCE, VOL. 249

POSITIONS OPEN POSITIONS OPEN

RESEARCH SCIENTISTSPromega Corporation is seeking talentedindividuals for the following areas:

CLINICAL DIAGNOSTICSMOLECULAR BIOLOGY

Research and development for directdetection of pathogenic organisms in clini-cal samples requires specialties in mo-lecular biology, enzymology, nucleic acidchemistry, non-radioactive detection andmedical microbiology. The project requiresnovel enzymatic approaches to targetamplification, the use of paramagneticparticles, and luminescent detection.

DNA TYPINGDevelopment of DNA typing products forpaternity/forensic applications includingnucleic acid probe labeling; Southern,Northern, and Western blots; and chemi-luminescent detection.Qualifications for these positions includea Ph.D. in a scientific discipline and atleast 2 years experience or a B.S. degreeand overall equivalent experience.We offer a competitive salary; compre-hensive benefits; a challenging, high-growth environment; career opportunities;and modern facilities. All information willbe kept in strict confidence. Toapply or forfurther information, forward a resume andsalary history or write to:

Promega CorporationHuman Resources/SCI2800 Woods Hollow RoadMadison, WI 53711-5399

Equal Opportunity Employer.

04mega

NCI FELLOWSHIP PROGRAM INCLINICAL ONCOLOGY AND CANCER

EPIDEMIOLOGYThe National Cancer Institute is accepting applications for a joint fellowshiptraining program in clinical oncology and cancer epidemiology. Physicians withmultidisciplinary training in clinical oncology, epidemiology, and etiologicresearch are becoming increasingly important in identifying cancer risk factorsthat may lead to further insights into human carcinogenesis and preventionstrategies. This fellowship program offers such multidisciplinary training tophysicians who have completed a minimum of two years in internal medicine orpediatrics.

The Clinical Oncology-Cancer Epidemiology Program is part of NIH's ClinicalAssociate Program, and offers three-year fellowships beginning July 1, 1991.The first year consists of clinical training in the Clinical Oncology Program,Division of Cancer Treatment. During this year, associates undertake theprimary care of inpatients and outpatients entered into clinical trials anddevelop expertise in cancer diagnosis and treatment. Openings are availablein the Medicine Branch, the NCI-Navy Medical Oncology Branch, and thePediatric Branch.

During the second and third years, associates spend about 80% of their time inthe Epidemiology and Biostatistics Program, Division of Cancer Etiology, andthe remainder of their time in continued clinical activities in the Division ofCancer Treatment. In the epidemiology program, associates work under thedirection of senior investigators in the Environmental Epidemiology Branch, theClinical Epidemiology Branch, the Radiation Epidemiology Branch, and theBiostatistics Branch. All Branches are involve in research into environmentaland host determinants of cancer. Opportunities for collaborative research mayalso be available in one of the intramural laboratories within the Institute.

This three-year fellowship is designed to fulfill the subspeciality requirementsfor Medical Oncology and Pediatric Hematology-Oncology. Candidates whohave completed at least one year of clinical oncology training may beconsidered for direct entry into the second year of this program. ClinicalAssociates may enter the U.S. Public Health Service by means of the CivilService or Commissioned Corps. For the Civil Service appointment, thestarting salary is $37,000, with annual increases of $2,000 for each additionalyear in the program. Salaries for Commissioned Officers vary based on levelof training and experience. Clinical Associates receive benefits that includehealth care, life insurance, vacation, and sick leave. In addition, moving andtravel expenses are provided.

For further information and application procedures, please contact either:

Gregory Curt, M.D.Clinical DirectorNational Cancer InstituteBldg. 10, Rm. 12N214Bethesda, MD 20892(301) 496-6375

Joseph F. Fraumeni, Jr., M.D.Associate Director forEpidemiology and BiostatisticsNational Cancer InstituteExecutive Plaza North, Rm. 543Bethesda, MD 20892(301) 496-1611

Deadline for Applications: March 1, 1991

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NATIONAL CANCER INSTITUTENATIONAL INSTITUTES OF HEALTH

U.S. PUBLIC HEALTH SERVICE

Li! NIH is an Equal Opportunity Employer

TWO RESEARCH SCIENTISTPOSITIONS

IMMUNOLOGY ANDMOLECULAR BIOLOGY

The R. W. Johnson Pharmaceutical ResearchInstitute is currently seeking two research sci-entists to join the Immunology group at theToronto, Canada site. The successful candi-dates will participate in a new drug discoveryprogram focusing on the use of cloned recep-tors for the discovery of novel antagonists ofadhesion molecules.The successful candidates should have Ph.D.degrees and postdoctoral experience. One posi-tion requires expertise in molecular biologywhereas the second position requires expertisein cellular immunology or cell biology. Experi-ence in the area of cell adhesion and leukocytemigration will be an asset.Please forward your curriculum vitae and refer-ences to: Mr. Pelly Shafto, Human Resources,R.W. Johnson Pharmaceutical Research Insti-tute, 19 Green Belt Drive, Don Mills, OntarioM3C 11L9 Canada.

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OPPORTUNITIESIN NEUROBIOLOGY

Amgen, a leader in the discovery and marketingof hematopoietic and tissue repair growth fac-tors, has made a significant commitment to thedevelopment of protein therapeutics to treat neu-rological disorders. We have immediateopenings at several career levels for scientists toparticipate in a multi-disciplinary research pro-gram to discover and develop novel neurotrop-hic factors using IN VITRO assays and IN VIVOmodels.

Successful candidates will have experience inone or more of the following: neuronal cell cul-ture, neuropharmacology, neuroanatomy, lesionand disease paradigms and nervous systemdevelopment. Additional expertise in immuno-logic techniques and molecular biology isdesirable.

RESEARCH SCIENTIST POSITIONS.Candidates should have a Ph.D. or equiv-alent in a relevant area and 1-3 years ofpostdoctoral experience. Additional expe-rience as an independent scientist in aca-demic or industry settings is desirable butnot essential.POST-DOCTORAL POSITIONS. APh.D. or equivalent in a relevant area ofneurobiology is required.RESEARCH ASSOCIATE POSI-TIONS. A Bachelor's degree or equivalentand relevant work experience in neurobi-ology, including neuronal cell culture orneurohistochemistry, are necessary.

Amgen offers a stimulating and challengingresearch environment on the leading edge ofbiotechnology. Our need for these positionsreflects an ever increasing commitment to thedevelopment of significant products for humanhealth care through excellence in research.

If you have the necessary skills and would like tobe a part of an organization that places a highpriority on its human resources, please send usa complete C.V. in confidence.

Amgen representatives will attend the upcom-ing Society of Neurosciences meeting. We willprovide the opportunity for confidential inter-views there. Please indicate if you plan toattend so that we may schedule interviewdates and times with you in advance.

AMGEN, INC.Recruitment, Dept. #557Amgen CenterThousand OaksCA 91320-1789EqualOpportunityEmployer

(The Science of SuccessSyntex has earned its reputation in the pharmaceuticalindustry for superior and innovative research. Ourstrong commitment to R&D has opened new doorsin patient care around the world. We have an out-standing opportunity for a Toxicologist to join us

in our Palo Alto research headquarters.

ToxicologistYou will be responsible for designing, monitoring, andreporting preclinical toxicology studies in a varietyof therapeutic areas. Information will be used to sup-port national and international regulatory findingsfor new drug registrations.

To qualify, you'll need a PhD in Toxicology or a relateddiscipline with 2 + years' postdoctoral experience.You'll also need familiarity with regulatory require-ments and the ability to work in a team-orientedenvironment. Excellent communication and inter-personal skills essential. Pharmaceutical or biotechbackground preferred.

Syntex, located on the San Francisco Peninsula, offersa competitive compensation and relocation package

which includes an incentive bonusplan. For immediate consideration,please send your resume to: Syntex,Professional Staffing, Dept. KH/SC,3401 Hillview Avenue, Palo Alto,CA 94303. We are an equal oppor-

SYNTEK( tunity employer.

UNIVERSITY OF MICHIGAN MEDICAL CENTERDEPARTMENT OF DERMATOLOGYThe Department of Dermatology is seeking an

individual to join a multidisciplinary group to investigatethe regulation of growth and differentiation of human skincells by retinoids (vitamin A-related compounds). Studieswill focus on the regulation ofgene transcription by nuclearretinoic acid receptors and characterization ofthe biologicalactivity of retinoic acid analogues. This information willprovide a better understanding of the molecular basis ofthe effects of retinoids on skin. Expertise in molecularbiology techniques preferred. Funding is available for atleast three years with possibility of long-term employment.

Interested persons should send their curriculum vitae toJohn J.Voorhees, M.D., Chairman, Department ofDermatology, University of Michigan Medical Center, 1301E. Catherine, Kresge 1, R6558, Ann Arbor, Ml 48109-0528.

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The Upjohn Company, arecognized leader in pharmaceuticalresearch and development, is seeking applications for theposition of Biochemistry Associate in our Control Biotech-nology Development group. This position requires either anM.S. in Biochemistry or a B.S. in a biological science andseveral years of relevant experience. Technical strength andinterest in protein biochemistry plus background and experi-ence with protein spectroscopy, chromatography and electro-phoresis are needed.The selected candidate will contribute tothe development of analytical methods that define proteinprimary structure and conformation for product registrationand stability studies.Upjohn offers a competitive compensation andbenefits pack-age in addition to a stimulating, multi-disciplinary researchand manufacturing environment at our modem facilities lo-cated in Kalamazoo, Michigan. Qualified applicants are in-vited to submit their resumes, cover letters and copies oftranscripts to: THE UPJOHN COMPANY, CORPORATERECRUMTING/5704-CA, 7000 PORTAGE ROAD, KALA-MAZOO, MI 49001-0199. Please refer to position number5704-CA in your cover letter. An Equal Opportunity Em-ployer M/F.OUR COMMrI ENET TO SCIENTIFIC EXCELLENCE CONTINUES...

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UNIVERSITY OF COPENHAGENFACULTY OF NATURAL SCIENCESPROFESSOR IN ASTROPHYSICS

Applications are invited for a Chair (Professorship) in Astrophysics at the Department ofAstronomy, from June 1, 1991.The Professor will be appointed as a Civil Servant under the Ministry of Education andResearch. The annual salary is approximately Danish Kroner 360.000.

Applicants with a special knowledge of theoretical astrophysics or of observational astrophys-ics (including instrumentation) will be considered. Applicants with a wide range of qualifica-tions within several areas - especially those relating to the Institute's field of research -would be preferred. Present and planned research projects are expected to be described inthe application.The research activities of the Institute are centered around distant galaxies and clusters ofgalaxies, the structure and development of the Milky Way, and stellar structure and evolutionincluding solar physics. The Institute is partly situated in Copenhagen and partly in Brorfelde.The scientific staff includes 1 full professor and 15 associate professors. Denmark is amember of ESO and ESA, and the Astronomical Observatory has two national telescopes(1 .5m and 0.5m) at the La Silla Observatory. Further, Copenhagen University is a user of theLa Palma Observatory and runs a fully automatic meridian circle there. From 1990 there will beaccess to the Nordic Optical Telescope at La Palma. The Institute has at its disposal highlyspecialized electronic and mechanical workshops as well as access to excellent computerfacilities. The Institute has an extended national collaboration (e.g. with the Danish SpaceResearch Institute and the Niels Bohr Institute) as well as an international collaboration.

The Professor will participate in the Department's teaching at all levels. The language ofinstruction is Danish, but English might be accepted for a period of two years after theappointment.

Applications should include copies of the scientific publications and further documentationwhich the applicant wishes to be considered, to be forwarded in triplicate together with a list ofall submitted material.

Information concerning the applicant's teaching experience must be included. A Study Board(studienaevn) will be asked to evaluate the applicant's teaching experience.Evaluation of the applicants qualifications will be undertaken by a specially appointed ScientificCommittee. The Committee's report will be sent to all applicants in an unabridged form.

Further information may be obtained from The Director, Astronomical Observatory, 0sterVoldgade 3, DK-1350 Copenhagen K, Denmark.

Applications are to be addressed to Her Majesty the Queen of Denmark and sent to the Facultyof Natural Sciences, Panum Instituttet, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.The closing date for receipt of applications is November 30, 1990 at 12 hours.

POSTDOCTORAL FELLOW/RESEARCH FELLOW/SENIOR RESEARCH FELLOWRESEARCH APPOINTMENTS IN PHOTOSYNTHESIS AND PHYSIOLOGICALPLANT PATHOLOGY, RESEARCH SCHOOL OF BIOLOGICAL SCIENCES, THEAUSTRALIAN NATIONAL UNIVERSITY. Several appointments are available andwill be filled over 2 years from May 1991. Applications are invited from personswho have or will acquire experience in the following areas: (a) Photosynthesis,especially in areas which may help relate light reactions and carbon metabolism.Expertise in fluorescence analysis or photoacoustic evaluation of photosystemprocesses and/or analysis of the function of pigmentprotein complexes is beingsought. Preference will be given to applicants with experience of theseapproaches in higher plants and their environments. (b) Physiological plantpathology, especially in areas to do with interactions between plant viruses andphotosynthetic functions. Applicants with experience in both plant photosynthet-ic physiology and virology will have an advantage. The successful candidates willjoin a research group in the School which will be headed by Professor C.B.Osmond, FRS, FM, who will take up his appointment as Director of the Schoolduring the first half of 1991. Initial enquiries can be directed to: Professor C.B.Osmond, Department of Botany, Duke University, Durham, NC 27706, USA ORProfessor B.E.S. Gunning, Acting Director, Research School of BiologicalSciences, The Australian National University, GPO Box 475, Canberra ACT 2601,Australia, telephone 61 6 2493841, facsimile 61 6 249 0758. Closing date: 5October 1990. Ref. BS 22.8.1. SALARY: Senior Research Fellow; A$45,729-A$54,255 p.a.; Research Fellow; A$33,163-A$43,096 p.a.; Postdoctoral FellowGrade 1 (fixed point); A$28,792-A$32,762 p.a. APPOINTMENT: Senior Re-search Fellow/Research Fellow up to three years, possibility of extension to fiveyears; Postdoctoral Fellow up to two years, possibility of extension to threeyears. APPLICATIONS should be submitted in duplicate to the Registrar, TheAustralian National University, GPO Box 4, Canberra ACT 2601, Australia,quoting reference number and including curriculum vitae, list of publications andnames of at least three referees. The University reserves the right not to make anappointment or to appoint by invitation at any time. Further information isavailable from the Registrar.

THE UNIVERSITY IS AN EQUAL OPPORTUNITY EMPLOYER

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POSITIONS OPEN

POSTDOCTORAL POSITION. Available imme-diately to study proteins/genes associated with cellularcompetence for shoot or callus induction in in vitro plantcultures. Ph.D. in plant biology required. Experience inplant tissue culture, protein biochemistry, and recombi-nant DNA techniques required. Send curriculum vitaeand names of three references by 17 October 1990 to:Dr. Stephen G. Ernst, Department of Forestry, Fish-eries and Wildlife, University of Nebraska-Lincoln,Lincoln, NE 68583-0814. Telephone: 402-472-6633. An Affirmative Action/Equal Opportunity Employer.

POSTDOCTORAL POSITION. Available imme-diately. Biologist/immunologist wanted with expertise inimmunology and molecular biology. Responsibilities willbe theproduction of anti-idiotype vaccines (hybridoma-.derived and recombinant antibodies) against cancer andAIDS. Please send your curriculum vitae with descrip-tion of previous research experience and two letters ofrecommendation to: Dorothee Herlyn, D.V.M., Asso-ciate Professor, The Wistar Institute, 3601 SpruceStreet, Philadelphia, PA 19104. FAX: 215-898-0980. Equal Opportunity Employer, MIF.

POSTDOCTORAL POSITIONSTo participate in molecular and genetic analyses of the

functions of extracellular matrix molecules in C. elgansdevelopment (e.g., Cell 55, 555;J. Biol. Chem. 264,17574; Mol. Cell. Biol. 10, 2081). Send curriculum vitaeand names of three references to: Dr. James M. Kramer,Laboratory for Molecular Biology MC067, Univer-sity of Illinois, P.O. Box 4348, Chicago, IL 60680.An Equal Opportunity/Affirmative Action Employer.

POSTDOCTORAL POSITION. Ph.D. (physiolo-gy, animal science, nutrition, or related area) for work inNIH-funded study of the effects of parenteral nutritionon intestinal growth and development in neonatal swine.Experience in intestinal function (e.g., transport, mor-phology, enzyme analysis, etc.) and experience handlingexperimental animals is preferred. Send curriculum vitaeand three letters of recommendation to: Mark G. Cle-mens, Ph.D., Pediatric Surgical Laboratory, JohnsHopkins University, School ofMedicine, Departmentof Surgery, CMSC 7-116, 600 North Wolfe Street,Baltimore, MD 21205.

POSTDOCTORAL POSMONS. Available imme-diately to study cell-extracellular matrix interactions atthe University of California, San Francisco (UCSF).Projects include the structural and functional character-ization of a novel metalloproteinase inhibitor, study ofmechanism(s) involved in the promotion of oncogenictransformation by this protein, and the identification andcharacterization of related members of this family ofproteins. Background in cell and molecular biology,biochemistry, or immunology desirable. Please send cur-riculum vitae and three letters of recommendation to:Dr. Susan P. Hawkes, Department of Pharmacy,UCSF, San Francisco, CA 94143-0446. UCSF is anAffirmative Action/Equal Opportunity Employer.

POSTDOCTORAL ASSOCIATE, PLANTFIREEMOLECULAR BIOLOGY. Cloning of reproductive-specific genes from poplar, genetic engineering of treesterility. Contact: Professor Steve Strauss, Departmentof Forest Science, Oregon State University, Corvallis,OR 97331-5705. Telephone: 503-737-2244, FAX:503-737-1393, email/internet: strauss @ fsl.orst.edu.Position availability closes 1 November 1990.

POSTDOCTORAL ASSOCIATEMOLECULAR CELL PHYSIOLOGYHARVARD MEDICAL SCHOOL

Two postdoctoral positions available immediately inthe molecular cell biology of transport proteins in polar-ized epitheial cells. One project focuses on structure-function relationships in Cl-/HCO3 exchanger pro-teins (JBC 263, 17092). The second project addressesthe function of the cystic fibrosis transmembrane regula-tor and its effects on ion transport. Both offer theopportunity to investigate determinants of epithelialpolarity (PNAS 86, 5429). Interested Ph.D.'s or M.D.'swith prior experience in molecular cell biology or intransport physiology should send curriculum vitae andthree references to: Seth L. Alper, M.D.-Ph.D., Molec-ular Medicinc Unit, Beth Israel Hospital, 330 Brook-line Avenue, Boston, MA 02215.

21 SEPTEMBER 1990

POSTDOCTORAL POSTIION. To study the roleof the microtubule cytoskeleton in celi motility andmorphogenesis. The project will focus on control ofmicrotubule dynamics by growth factors and will com-bine biochemical, immunological, and video-based mi-croscopy approaches. Send curriculum vitae and threeletters of reference to: Dr. Gregg G. Gundersen, De-partment of Cell Biology ani Anatomy, ColumbiaUniversity, College of Physicians and Surgeons, 630West 168th Street, New York, NY 10032. We takeAffirmativeAction toward Equal Opportunity.

POSTDOCTORAL FELLOWSHIP. The Hema-tology Division, Vanderbilt University, is seeking quali-fied postdoctoral candidates to pursue basic research inthe thrombosis and hemostasis field. Areas of researchinclude: structure and functions of serine proteases andtheir inhibitors, regulation of serpin biosynthesis. Can-didates must have a strong background in protein bio-chemistry or in cellular and molecular biology. Sendcurriculum vitae to: Dr. Marc Sclhapira, VanderbiltUniversity, Hematology Division, Nashville, TN37232. Vanderbilt University is an Equal Opportunity/Affir-mativeAction Employer.

POSTDOCTORAL FELLOWSHIPS. The Line-berger Cancer Research Center of the University ofNorth Carolina (UNC) at Chapel Hill will have openingsin 1990-91 for persons completing graduate studies totrain with excellent investigators in basic research intumor virology, chemical carcinogenesis, drug develop-ment, cancer cell biology and tumor immunology. Train-ing is available in recombinant DNA technology, geneexpression, DNA replication, mutagenesis, molecularenzymology, regulation of cellular proliferation, growthfactors, immunogenetics, molecular genetics of cancer,and combined programs. Unique training resources andcore facilities are housed in the NCI-designated Line-berger Comprehensive Cancer Center. Candidates must beU.S. citizens or permanent residents. Send for brochurelisting faculty and apply with curriculum vitae, threeletters of recommendation, a statement of research inter-ests, and graduate school records to: Director, CB#7295, Lineberger Comprehensive Cancer CenterSchool of Medicine, University of North Carolina atChapel Chapel hapel Hill, NC 27599. UNC's CancerResearch Center is an Affimative Action/Equal OpportunityEmployer. Minority applicants are encouraged voluntarily toidentify demselves.

The Department of Neurosciences, University of Cal-ifornia, San Diego (UCSD), is seeking qualified appli-cants for positions as ASSISTANT RESEARCHNEUROSCIENTIST and POSTDOCTORAL FEL-LOW. The qualified individuals will be involved in theresearch of the molecular aspect of neurodegenerativedisease, especially ischemia, for a period of 3 years.Successful candidate is expected to have a strong back-ground of biochemistry and molecular biology. Currentfocus of research is biochemical and molecular biologicalcharacterization of protein kinases and molecules in-volved in phosphorylation cascade reactions during ani-mal mode[ofischemia. Salary will be commensurate withcandidate's experience and university policy. Send curric-ulum vitae and names and addresses of five references to:Drs. Tsunao Saitoh or Justin Zivin, U.C.S.D., De-partment of Neurosciences, 9500 Gilman Drive, LaJolla, CA 92093-0624. UCSD is anAfirmtaveActioniEqual Opportunity Employer. Closing date for applicationsis 31 October 1990.

HUMAN CHEMORECEPTION. The John B.Pierce Laboratory, devoted to research and education inhealth and the environment and affiliated with YaleUniversity, seeks an ASSISTANT FELLOW (analo-gous to assistant professor) with experience in the humansense of smell and sensory irritation to join an ongoingresearch program. Applicants should have a doctoraldegree in a relevant specialty. Experience in pharmacol-ogy/toxicology and biochemistry would be particularlydesirable. Applicants should send curriculum vitae, astatement of research plans, representative publications,and the names of three references by 1 November 1990to:

Human Chemoreception Search CommitteeThe John B. Pierce Laboratory

290 Congress AvenueNew Haven, CT 06519-1403

The John B. Pierce Laboratory is an Equal Opportunity/Affirmnative Action Employer.

Cytel is a growing biotechnology com-pany pursuing recent breakthroughsin the field of immunology, virologyand vascular biology. Company focusis on the discovery and development ofnovel regulatory molecules throughinnovative concepts in a rational drugdesign.Candidates with expertise in the fieldof cellular immunology/immuno-chemistry are sought to participate inan aggressive research and develop-ment program at the postdoctoral andstaff scientist levels. To qualify, an in-dividual must have a Ph.D. in bio-chemistry, immunology, cell biologyor equivalent, and a working knowl-edge of basic immunochemistry andcellular immunology techniques. Ex-perience in antigen recognition ofT cells is favored.Cytel offers competitive salaries andexcellent benefits. For immediate con-sideration, please send your resumeto:

Cytel CorporationDept. AS

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MCIENCAE

POSITIONS OPEN

POSITIONS OPEN

ADVANCED POSTDOCTORAL or RE-SEARCH ASSOCIATE POSMIION, Center forAIDS Research at Stanford: Ph.D. or M.D. with up to 2or 3 years of advanced postdoctoral training or experi-ence in viral immunology, cellular immunology, proteinchemistry, or related fields to implement a funded pro-gram under a National Cooperative Vaccine Develop-ment Group for AIDS. The work involves new adjuvantapproaches for recombinant subunit proteins, to bestudied in vivo and in vitro viral models to determine thebest methods of administrating HIV antigens in futurevaccine efforts. The candidate should be capable ofconducting an active independent research programwhich would be a component of a larger effort in the areaof host resistance to viral infection. Interested applicantscontact: Thomas C. Merigan, M.D., Director, Centerfor AIDS Research, Stanford University, Stanford,CA 94305. Stanford University is an Equal OpportunityEmployer.

POSTDOCTORAL RESEARCHIN CELL BIOLOGY

CENTER FOR BASIC RESEARCHIN DIGESTIVE DISEASES

MAYO CLINICPostdoctoral position available for recent Ph.D. or

M.D. to study the molecular and biochemical mecha-nisms of secretion in digestive tissues. Experience inimmunological, molecular, or biochemical techniques isdesirable. Applicants must be U.S. citizen. Send curriculumvitae, statement of research interests, and names of threereferences to: Dr. N. F. LaRusso, Director, Center forBasic Research in Digestive Diseases, Guggenheim17, Mayo Clinic, Rochester, MN 55905. An EqualOpportunity/Affirmative Action Employer.

ASSISTANT RESEARCHER/POSTDOCTOR-AL SCIENTIST. Retroviral Research Laboratory, Can-cer Research Center of Hawaii, has a full-time positionbeginning November 1990, federal grant fundingthrough September 1991, competitive renewal thereaf-ter. Incumbent will conduct clinical and epidemiologicalstudies of HIV proviral sequences in patients. Theproject will use molecular technology to develop diag-nostic and prognostic markers to follow individualsinfected with HIV. Minimum requirements: Ph.D. in anappropriate discipline, or an M.D. with research experi-ence in molecar biology. Minimum annual salary:$35,376. To apply send curriculum vitae and names,addresses, and telephone numbers of four references to:Dr. Tom Humphreys, University of Hawaii, PacificBiomedical Research Center, 1993 East-West Road,Honolulu, HI 96822. Inquiries: 808-539-7327. Clos-ing date: 1 November 1990. Equal Opportunity/Aflir-mative Action Employer.

RESEARCH ASSOCIATE to conduct research onreversible immortalization of neural and muscle cells,developing new approaches to the treatment of musculardystrophy and other degenerative diseases. Candidatesmust have a M.S. in biochemistry with 3 years researchexperience in molecular genetics and gene manipulation.The successful candidate must have research experiencein: (i) primary muscle cell culture and neural cell culture;immortalization of neural and musde cells; (ii) antisenseoligodeoxynucleotide construction and manipulation;expression vector construction for immortalization; (iii)tumor suppressor gene expression and regulation inneural and muscle cells; (iv) cell analysis by flow cytom-etry and the MTT method. Forty hours per week;$27,000 per year. Send this ad and your resume induplicate to: C. Wester, UCLA/Reed Neurology, 710Westwood Plaza, Los Angeles, CA 90024-1769. AnEqual Opportunity Employer.

DIRECTOR, ELECTRONIC ENGINEERING(Computer Science). Design and develop algorithms andsoftware systems for multidimensional medical imagedisplay and analysis, for VIEW-2000 and Stardent work-stations, using imaging modalities such as CT and MRI.Must have Ph.D. in computer science for medical appli-cations or biomedical engineering and image processingplus 2 years of experience in this job or related research.Must be able to develop software for VIEW-2000 andStardent and have combination of theory and designengineering, and experience must be in field of low-levelsegmentation ofCT and MRI. Salary: $61,800 per year.Job and interview in Brea, California. Send this ad andresume to: Job #BLW18267, P.O. Box 9560, Sacra-mento, CA 95823-0560 by 5 October 1990.

1470

POSTDOCTORAL ASSOCIATEOpportunity to participate in ongoing research di-

rected at: charactenzation of the genes and molecularmechanisms involved in the formation of meningiomasand other neural crest tumors; molecular and cellularcharacterization of a recently identified oncogene/DNAbinding protein. Send curriculum vitae with the names,addresses, and telephone numbers of three references to:Dr. Donna George, Department ofHuman Genetics,Howard Hughes Medical Institute, University ofPennsylvania School of Medicine 422 Curie Boule-vard, Philadelphia, PA 19104-6145. An Equal Oppor-tunity Employer.

POSTDOCTORAL RESEARCH ASSOCIATEA postdoctoral research associate position, funded for

3 years, is available immediately to study tissue-specificregulation of a human gene. Research involves molecularcloning and expression of genes for transcription factors,transcriptional studies, and protein purification. Candi-dates must have biochemistry and/or molecular biologybackground. Salary will be commensurate with experi-ence. Please send resume and arrange to have three lettersof references sent to: Gokul C. bas, Department ofMolecular Biology, The University of Texas HealthCenter at Tyler, P.O. Box 2003, Tyler, TX 75710.FAX: 214-877-7558.An Afinnative AciooEqual Opportunity Employer.

RESEARCH ENGINEER. Develop hybrid speechrecognition system using advanced signal processing andacoustic phonetic knowledge base. Develop software torecognize and understand human speech. Must havePh.D. plus 6 months of experience or M.S. plus 4 yearsof experience; degree must be in Computer Science orElectronic Engineering. Experience must include ad-vanced signal processing, phoneme-based stochasticmodeling of speech, neural net theory and techniques,and knowledge base construction and application formachine intelligence. Must have research experience in

automatic speech recognition. Job and interview in SantaBarbara, California. Salary: $4685 per month. Send thisad and resume to: JOB #KV17958, P.O. Box 9560,Sacramento, CA 95823-0560 by 5 October 1990.

RESEARCH INVESTIGATOR. The Departmentof Dermatology, University of Michigan, seeks a Ph.D.with one or more years of postdoctoral experience inmolecular and/or cellular biology to join an establishedlaboratory studying the molecular biology of growthregulation and gene regulation in human skin. Areas ofinterest include: receptor tyrosine kinases, growth factorgene regulation, retinoid and steroid receptors, anddermal-epidermal interactions. Send curriculum vitaeand two letters of reference to: James T. Elder, M.D.,Ph.D., University of Michigan, C560 MSRB II, Box0672, Ann Arbor, Ml 48100672. An Equal Oppor-tunity/Aflirmative Acaion Employer.

The California Air Resources Board is accepting ap-plications for AIR POLLUTION RESEARCH SPE-CIALISTS. Applicants must have a bachelor's degreewith major work in engineering, math, or physical/biological/environmental sciences and 4 years of experi-ence mn those areas including 1 year of specialized expe-

rience in research consultation and determination of

research design/methods for studies in air pollution orrelated field. May substitute graduate work on year foryear basis for 3 years of experience. Salary: $3741 to$4516 per month plus benefits. Inquire before 15 Octo-ber 1990. Write to: Air Resources Board, 1234 UStreet, Sacramento, CA 95818 or telephone: 916-323-1158.

FISHERY RESEARCH. The Texas Parks and Wild-life Department seeks two RESEARCH SPECIAL-ISTS in the Coastal and Inland Fisheries Branches todesign, perform, and report applied quantitative researchinto broad aspects of fishery management, manage databases, and support technical programs. Qualifications

include an M.S. degree in fishery science, biology, statis-tics or related field, and expertise in staiastics and com-puting. Applicants with Ph.D. are welcome. Salary is$31,848. Contact: Steve Gutreuter, Ph.D., InlandFisheries Branch, telephone: 512-389-4652, orMaury F. Osborn, Coastal Fisheries Branch, tele-phcnqe: 512-389-4647, Texas Parks and WVildlife De-partment, 4200 Smith School Road, Austin, TX78744. An AffirmativeAction/Equal Opportunity Employer.

ARNOLD RESEARCH COORDINATOR. TheArnold Arboretum of Harvard University invites appli-cations for a coordinator to manage a multidisciplinaryresearch project in the rain forests of tropical Asia underthe local direction of Professor Peter Ashton. Responsi-bilities will include: establishment of field research sitesin cooperation with country scientists; coordination ofdata collection, including site visits and supervision ofproject personnel; establishment, management, and anal-ysis of a central database; preparation of reports andresearch publications. Qualifications will indude Ph.D.in plant biology; field experience in tropical forests,preferably in Asia; proven managerial skills with collab-orative programs; experience with computer databasemanagement; demonstrated research capabilities. Sendr6sumei, letter of interest, and the names of three refer-ences to: Dr. Robert E. Cook, Arnold Arboretum,125 Arborway, Jamaica Plain, MA 02130.

RESEARCH ASSOCIATE to perform research ondegenerative neurological diseases using genetic engi-neering techniques to develop in vitro models, and todevelop treatments employing gene therapy approaches.Required qualification: M.S. degree with a minimnum of3 years of experience or M.D. degree. Laboratory expe-rience must include (i) preparation and characterizationof DNA/RNA and plasmid DNA, polymerase chainreaction (PCR), clomng and subcloning of cDNA, pu-rification and labeling of oligonudeotides, microinjec-tion, and familiarity with head and neck cancers andassociated oncogenes; (ii) primary cell culture and clon-ing, immunofluorescent assay, enzyme-linked immuno-sorbent assay (ELISA), virus stocks and infected cells;(iii) microsurgery on embryonic brain. Forty hours perweek; $29,784 per year. Send this ad and your resume induplicate to: C. Wester, Reed Neurology/UCLA, 710Westwood Plaza, Los Angeles, CA 90024-1769. AnEqual Opportunity Employer.

STAFF SCIENTIST position available to conductresearch and development on tests that will detect chem-ically induced structural and chromosome aberrationsand aneuploidy in somatic and germ cells. Ph.D. ingenetics and a minimum of2 years of research experiencein conducting in vivo chromosome aberrations and aneu-ploidy assays using antikinetochore and antibodytaLzgnis required. Salary: $18.60 per hour. Please mall rsumndeand copy of ad to: Department of Economic andEmployment Development, 1100 North EutawStreet, Room 212, Baltimore, MD 21201. Job order# 8945159. Job location: Rockville, Maryland.

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SCIENCE, VOL. 249

POSITIONS OPEN POSITIONS OPEN

Inflammationhlmmunology

Research Opportunities

Pfizer Inc is an international leader in the researchand development of health care products. The De-partment of Immunology and Infectious Diseases ofthe Central Research Division is committed to innova-tive research leading to the discovery of novel thera-peutics for the treatment of inflammatory diseases.Our approach to drug discovery encourages indi-vidual creativity as an important element in guiding ateam effort toward a therapeutic target. This philoso-phy results in an environment that is challenging tothe individual while enhancing group productivity.Scientific growth and development are stimulated byfrequent interactions with prominent scientists inacademia and medicine as well as with members ofthe research community within Pfizer.

A PhD degree, appropriate postdoctoral training anda record of accomplishment in your research en-

deavors is required for each of the following posi-tions. Previous industrial research experience is wel-come but not essential.

Osteoarthritis- We seek both a laboratorysupervisor and a research leader in this area. Thelatter position is distinguished by a requirement formore extensive research experience in OA in orderthat the individual be capable of playing a clearscientific leadership role. Both positions would focuson developing and applying-systems related to thepathogenesis and treatment of osteoarthritis. Appro-priate fields of training include protein biochemistry,molecular biology, cell biology or experimental pa-thology. For those with in vitro expertise, experiencewith cartilage/chondrocyte biochemistry/metabolismis required (with regulation by cytokines being ofparticular interest). For those whose primary experi-ence has been with in vivo models of osteoarthritis,experimental assessment of mechanisms and phar-macological effects will be important.

Inflammation Models - This position callsfor research experience in the area of acute andchronic in vivo models of pain and/or inflammatorydisease (including, but not limited to, arthritis). It willinvolve the application of known models and estab-lishment of new ones relevant to novel drug targets.The abilityto extract multiple levels of information fromsuch models is particularly important (e.g., sympto-matic, histological, biochemical, electrophysiologi-cal, behavioral).Pulmonary Diseases - We seek two sci-entists to contribute to the discovery of new anti-asthma/allergy therapies. Current interests encom-pass the pharmacologic manipulation of leukocytefunctions/interactions in models of airway inflamma-tion/hyperreactivity. One position calls for experiencewith animal models of pulmonary disease and theirmechanistic basis. Appropriate fields of training in-clude physiology, pathology or pharmacology. Expe-rience with methods and theory of pulmonary me-chanics is especially desired. The second positionwill focus on immune cell regulation, with a particularemphasis on modulation of cytokines, receptors andsignal transduction processes. Appropriate fields oftraining include immunology, biochemistry, cell biologyor pharmacology. For this position, prior research onproblems associated with immediate and delayed hyper-sensitivity reactions is desirable, but not required.We offer a stimulating research environment and anexcellent opportunity for professional recognition andadvancement. In addition, we provide a competitivesalary/benefits package and an opportunity to live inan attractive Connecticut shore community. Qualifiedapplicants should submit their resume and refer-ences in confidence to: Dr. Jerry K. Larson, AssistantDirector, Employee Resources, Central Research Di-vision, Pfizer Inc, Eastern Point Road, Groton, Con-necticut 06340. An equal opportunity employer.

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