polysaccharide a a widely distributed immunoregulatory microbial product matthew rhodes and...
TRANSCRIPT
Polysaccharide Aa widely distributed immunoregulatory microbial product
Matthew Rhodes and Catherine LozuponeUniversity of Colorado, Denver
Rocky Mountain Bioinformatics Conference
December 11th 2014
Mazmanian and Kasper 2006
Mazmanian 2009
The Microbial Health Factor (PSA)
One bacterial molecule sufficient to mediate healthy immune response!!!
BAD GOODPSA
The B. fragilis PSA Operon
Coyne et al. 2001
E-ValueH
its to
wcf
RNext best hit in B. fragilis (PSB)
IL-10 Production Amongst PSA Producers
Red: PSA Black:No-PSA
0
200
400
600
IL-1
0 (p
g/m
l)
Neff unpublished
PSA and HIV
Erysipelotrichales and HIV OTUs
Red: Genome without PSAOrange: OTU up with HIVGreen: Genome with PSABlue: OTU down with HIV
Thank You!!!Lozupone LabPalmer LabSarkis Mazmanian and other CollaboratorsComputational Bioscience for Funding