photo credit: firefly with glow, by terry priest on flickr (creative commons)//flic.kr/p/h1kaj

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Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)http ://flic.kr/p/ h1KAJ

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Page 1: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ

Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)http://flic.kr/p/h1KAJ

Page 3: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ

(Protein)

Page 4: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 6: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 7: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ

Transcription

The decision to transcribe a gene is the most important step in the control of gene expression.

Transcription starts and stops at distinct sites at the ends of a gene.

A gene

Animation

Page 8: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ

Eukaryotic Genes are Segmented

Genes are made of parts represented in the mRNA (exons) and parts that are transcribed but not present in the mRNA (introns).

In some genes more than 90% of the pre-mRNA is destroyed, never to appear in the mRNA.

Introns are removed from the primary transcript and exons are spliced together to make mRNA.

Animation

Page 9: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ

Alternative Splicing – More Bang for the Buck

This has the consequence that the count of our genes (~20,000) seriously underestimates the count of our different proteins.

Page 10: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ

The Genetic Language Uses 4 Letters Written Into 3-Letter Words

Page 11: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 12: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 13: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 14: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 18: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 19: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 23: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 24: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 25: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 28: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 29: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ
Page 30: Photo credit: Firefly with glow, by Terry Priest on Flickr (Creative Commons)//flic.kr/p/h1KAJ

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