(Continued from page 1499)

Non-Radiometric Assays. Technology and Applica-tion in Polypeptide and Steroid Hormone Detection.Barry D. Albertson and Florence P. Haseltine, Eds. Liss,New York, 1988. xx, 361 pp., illus. $68. Progress inClinical and Biological Research, vol. 285. From ameeting, Bethesda, MD, Oct. 1987.

Optical Nonlinearities and Instabilities in Semi-conductors. Hartmut Haug, Ed. Academic Press, SanDiego, CA, 1988. xii, 400 pp., illus. $65.Optimal Experience. Psychological Studies of Flow

in Consciousness. Mihaly Csikszentmihalyi and IsabellaSelega Csikszentmihalyi, Eds. Cambridge UniversityPress, New York, 1988. xiv, 416 pp., illus. $37.50.Oxy-Radicals in Molecular Biology and Patholo-

gy. Peter A. Cerutti, Irwin Fridovich, and Joe M.McCord, Eds. Liss, New York, 1988. xx, 586 pp., illus.$110. UCLA Symposia on Molecular and Cellular Biolo-gy, vol. 82. From a symposium, Park City, UT, Jan.1988.

Particle Physics and Introduction to Field Theory.T. D. Lee. 2nd ed. Harwood, New York, 1988. xviii,865 pp. $82; paper, $24. Contemporarv Concepts inPhvsics, vol. 1. Updated reprint, 1981 ed.Peregrine Falcon Populations. Their Management

and Recovery. Tom J. Cade et al., Eds. The PeregrineFund, Boise, ID, 1988. xviii, 949 pp., illus. + plates.$45. From a conference, Sacramento, CA, Nov. 1985.Physical and Computational Aspects of Convec-

tive Heat Transfer. Tuncer Cebeci and Peter Bradshaw.2nd ed. Springer-Verlag, New York, 1988. xii, 487 pp.,illus. Paper, $45.The Physics and Applications of Amorphous

Semiconductors. Arun Madan and Melvin P. Shaw.Academic Press, San Diego, CA, 1988. xii, 545 pp., illus.$69.50.Physics at LEAR with Low Energy Antiprotons.

C. Amsler et al., Eds. Harwood, New York, 1988. xviii,827 pp., illus. $112. Nuclear Science Research Confer-ence Series, vol. 14. From a workshop, Villars-sur-Ollon,Switzerland, Sept. 1987.

Probability and Inference in the Law of Evidence.The Uses and Limits of Bayesianism. Peter Tillers andEric D. Green, Eds. Kluwer, Norwell, MA, 1988. xii,345 pp., illus. $79. Boston Studies in the Philosophy ofScience, vol. 109. Based on a symposium, Boston, MA,April 1986.

Probability in the Sciences. Evandro Agazzi, Ed.Kluwer, Norwell, MA, 1988. x, 269 pp. $59. SyntheseLibrary, vol. 201.

Schirra's Space. Walter M. Schirra, Jr. with RichardN. Billings. Quinlan, Boston, 1988. xii, 227 pp. +plates. $16.95.School Matters. Peter Mortimore et al., University of

California Press, Berkeley, 1988. vi, 313 pp. $35; paper,$12.95.Science and Civilisation in China. Vol. 5, Chemis-

try and Chemical Technology. Part 9, Textile Technolo-gy: Spinning and Reeling. Dieter Kuhn. CambridgeUniversity Press, New York, 1988. xxoxiv, 520 pp., illus.$110.Science and Corporate Strategy. DuPont R&D,

1902-1980. David A. Hounshell and John Kenly Smnith,Jr. Cambridge University Press, New York, 1988. xx,756 pp., illus. + plates. $39.50. Studies in EconomicHistorv and Policy.Simulation Fidelity In Training System Design.

Bridging the Gap between Reality and Training. RobertT. Havs and Michael J. Singer. Springer-Verlag, NewYork, 1989. xx, 415 pp., illus. Paper, $39. RecentResearch in Psychology.Single-Mode Fibers. Fundamentals. E.-G. Neu-

mann. Springer-Verlag, New York, 1988. xiv, 530 pp.,illus. $89.50. Springer Series in Optical Sciences, vol. 57.The Social Psychology of Knowledge. Daniel Bar-

Tal and Arie W. Kruglanski, Ed. Cambridge UniversityPress, New York, and Editions de la Maison des Sciencesde l'Homme, Paris, 1988. xii, 399 pp. $54.50.

Social Structure and Personal^ty Development.The Individual as a Productive Processor of Reality.Klaus Hurrelrnann. Cambridge University Press, NewYork, 1988. x, 163 pp. $34.50; paper, $12.95.Solitons and Polarons In Conducting Polymers.

Lu Yu. World Scientific, Teaneck, NJ, 1988. xvi, 754pp., illus. $78; paper, $37.Solvents and Solvent Effects in Organic Chemis-

try. Christian Reichardt. 2nd ed. VCH, New York,1988. xxii, 534 pp., illus. $98.Somatic Cell Genetics of Woody Plants. M. R.

Ahuja, Ed. Kluwer, Norwell, MA, 1988. xxii, 225 pp.,illus. $59. Forestry Sciences. From a meeting, Gros-shansdorf, F.R.G., Aug. 1987.

17 MARCH I989

POSITIONS WANTED

Biochemist. Ph.D. Extensive experience in lipoproteinand cholesterol metabolism in tissue culture systems andanimal models. Enzymology, protein isolation and char-acterization, receptor studies. Strong publications. Seeksacademic or industrial position. Box 36, SCIENCE.

Biopharmaceutics/Pharmacokinetics, Ph.D. with 11years ofexperience in academia seeks position in pharma-ceutical industry evaluating clinical protocol, trainingrepresentatives, professional relations or similar position.References and resume available upon request. Box 37,SCIENCE.

Chemist, Biochemist, Physiological Sciences, Ph.D.,M.D., Extensive teaching: clinicaland analytic biochem-istry, cancer, instrumentation; visible, UV, infrared,TLC, GC, electrophosis, fluorometry; government, aca-demic/hospital. Box 354, Rochelle Park, NJ 07662.

POSITIONS WANTED

Environmental/Comparison Physiologist, Ph.D. Es-tablished investigator with publications in thermoregula-tion, perinatal development, and drug-stress interaction.Current funding in ethanol research. Seeks academicposition offering teaching and research opportunities.Box 27, SCIENCE.

Insect Biochemist. Ph.D. Entomology, M.S. Biochem-istry; expert HPLC, expert enzyme, expert hormones,expert Macintosh, antibodies, Polydna virus, phero-mones, reviewer for Science. Seeks research position.Box 22, SCIENCE.

POSITIONS OPEN

Environmental Monitoring Research Branch, ANA-LYTICAL RESEARCH LABORATORY MANAG-ER, Georgia Tech Research Institute. Our Environment,Health and Safety Division is currently seeking an analyt-ical chemist who meets the following minimum require-ments: (i) Ph.D. in analytical chemistry. (ii) Minimum of5 years of experience beyond doctorate. (iii) Excellentresearch reputation in indoor air quality. (iv) Broad-based analytical experience. (v) Experience in environ-mental protection issues. (vi) Ability to manage activitiesof analytical facility. GTRI offers competitive salaries andan outstanding benefits package. Send resume to: RussCappello, Technical Recrunter, Human ResourcesDepartment, Code: SCI-2 Georgia Tech ResearchInstitute, Georgia Institute of Technology, Atlanta,GA 30332-0800. An Equal Education/Employment Op-portunity Institution.

ANATOMY POSITIONUNIVERSITY OF NEW ENGLAND

The Division of Life Sciences invites application for atenure-track position in anatomy and physiology at therank of assistant professor. Requirements include aPh.D. in anatomy and experience in undergraduateteaching. Other desirable experiences/interests includeinterdisciplinary curriculum development, scholarship,and teaching students in physical/occupational therapyprograms and life science majors. Duties include teachinggross human anatomy, neuroanatomy, and anatomy/phy-siology courses. Projected starting date is summer 1989.Submit a resume and a statement of teaching goals by 7April 1989 to: Mr. Michael Miles, Director of Person-nel, University of New England, Biddeford, ME04005. The University of New England is an AffirmativeAction/Equal Opportunity Employer.

ASSISTANT PROFESSOR IN ANATOMY. Ap-plications are invited from qualified individuals possess-ing the Ph.D. or M.D. degree and a minimum of 2 yearsof postdoctoral studies, for a position at the rank ofassistant professor. The responsibilities of the positioninclude participation in microscopic and neuroanatomycourses taught to medical and graduate students, anddemonstration of an active, productive research programin cell and/or molecular biology.

Applications should include curriculum vitae and thenames of three references, and sent before 1 May 1989to: Anthony J. Shmidt, Ph.D., Professor and Chair-man, Department of Anatomy, Rush Medical Col-lege, 1653 West Congress Boulevard, Chicago, IL60612.

Rush University is an Equal Opportunity/Affirmative ActionEmployer.

ASSISTANT PROFESSORS, School of Pharmacy,University of Colorado. Applications are invited for twotenure-track positions at the assistant professor level in

pharnacology/pharmaceutical chemistry. Positions re-quire a Ph.D. in an appropriate area and relevant post-doctoral experience. Preference will be given to thosehavin an undergraduate degree in pharmacy. The suc-cessful applicants will be expected to develop strongextramuraly-funded research programs in their areas ofinterest. Other responsibilities include teaching at theundergraduate and graduate levels. Applicants shouldsubmit curriculum vitae, a one-page summarv of researchplans, and the names and addresses of three references by20 April 1989 to: Dr. John A. Thompson, School ofPharmacy, University of Colorado, Boulder, CO80309-0297. The University of Colorado is an EqualOpportunity/Afirmative Action Employer.

PERSONNEL PLACEMENT 150I

PersonnelPlacement

SCIENCE publishes each Friday, except the last Fridayof the year. Advertising is accepted only in writing; noabbreviations. Any deadline in ad must be at least 2weeks after date of issue in which ad appears. Also,personnel advertising is accepted only with the under-standing that the advertiser does not discriminateamong applicants on the basis of race, sex, religion,age, color, national origin, handicap, or sexual prefer-ence. SCIENCE reserves the right, in its discretion, todecline to publish advertisements submitted to it.

LINE CLASSIFIED ADVERTISING DEADLINES:Thursday, 10 a.m., 2 weeks prior to issue date (mailedon issue date). For deadlines for display advertising,please contact Scherago Associates.

POSITIONS WANTED: 400 per word, plus $4 for use ofbox number, per week. $10 minimum, per week.Prepayment required. This rate is available only toindividuals seeking jobs.

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To ESTIMATE ad cost:Structure ad copy on a separate page, on lines of 52characters and spaces. Include any desired heading.Each line of heading, and/or extra line spaces, and allpartial lines (including centered reply information) arecounted as full lines. Ad titles located within the textare printed in boldface caps and are only 32 charac-ters per line. In ESTIMATING the cost, multiply totallines x $40.00 = approximate cost of ad. (This is anapproximate cost ONLY: Allow for variation betweenestimated lines and actual typeset lines and the result-ing final cost. Purchase orders must allow for somedegree of flexibility and/or adjustment.)

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1333 H Street, NWWashington, DC 20005

POSITIONS OPEN

ASSISTANT DIRECTORDIAGNOSTIC MOLECULAR GENETICS

The Department of Pathology (Diagnostic Labora-tories) of Vanderbilt University Medical Center invitesapplications for the position of Assistant Director, Im-munopathology Laboratory, Division of Molecular Ge-netics. Candidates must have a Ph.D. degree with exten-sive experience in molecular biology techniques withparticuar interest in the development of diagnostic tests.Faculty appointment available commensurate with cre-dentials.

Please submit curriculum vitae, synopsis of researchinterests and career objectives to:

Thomas L. McCurley, M.D.Director, Immunopathology LaboratoryRoom 4605, The Vanderbilt Clinic

Vanderbilt University Medical CenterNashville, TN 37232-5310

Vanderbilt University is an Equal Opportunity/AffirmativeAction Employer.

ASSISTANT PROFESSORCELL PHYSIOLOGY/

ELECTRON MICROSCOPYThe Biology Department at the University of Puget

Sound is accepting applications for a tenure-track posi-tion in the areas of cellular physiology and electronmicroscopy to bein Augu t 1989. Requires Ph.D.,strong backgroun in cular-animal physiology andelectron microscopy, and a commitment to undergradu-ate teaching. Special areas of interest include endocrinol-ogy, neurobiology, immunology and epithelial transport.Teach a course which meets the physiology requirementfor biology majors, participate in the introductory biolo-gy program, offer an advanced elective specialty courseand provide department with expertise in electron mi-croscopy. Initiate/maintain a strong research programinvolving undergraduates, participate in student advisingand departmentalUniversity governance, and continueprofessional development. The Department has nine full-time faculty with diverse expertise and modern facilitiesincluding an electron microscope laboratory with a ZeissEM 109 TEM and ISI SS40 SEM. Submit letter describ-ing interests and goals, curriculum vitae, transcripts andthree letters of reference by 7Aprl 1989, to: PhysiologySearch, University of Puget Sound, P.O. Box 7297,Tacoma, WA 98407. An Equal Opportunity/AffirmativeAction Educator/Employer.

THE UNIVERSITY OF CALGARYASSISTANT PROFESSOR IN

BIOCHEMISTRYThe University of Calgary Department of Biological

Sciences invites applications for a tenure-track appoint-ment in biochemistry at the assistant professor leveleffective 1 January 1990.

Requirements include a minimum of 2 years of post-doctoral experience with a record of creative work andpotential for teaching and developing an independentresearch program. Applicants with an interest in anyaspect of contemporary protein biochemistry will beconsidered but those with experience in aspects of thestructure and function of membrane proteins, glycopro-teins, or transport and translocation mechanisms, and awillingness to teach a course on modern membranebiochemistry will be preferred.The Biochemistry Division of the Department of

Biological Sciences is responsible for the undergraduateprogram in biochemistry and contributes to the graduateprogram in coordination with the Department of Medi-cal Biochemistry. The Department is well-equipped forprotein biochemistry and DNA sequencing. State-of-the-art equipment for biological fermentations, 400- and500- MHz NMR and access to the University's CYBER205 supercomputer are available.

Salary and rank are commensurate with qualificationsand experiences. In accordance with Canadian immigrationrequirements, priority will be given to Canadian citizens andpermanent residents of Canada. The University of Calgary iscommitted to employment equity.

Qualified individuals should send curriculum vitae, adetailed description of their research objectives andarrange to have three letters of reference sent by 1 May1989 to: Dr. T. A. Thorpe, Head, Departnent ofBiological Sciences, The University of Calgary, 2500University Drive N.W., Calgary, Alberta, CanadaT2N 1N4.

POSITIONS OPEN

ASSISTANT PROFESSOR: To conduct and super-vise independent research in the metabolic roles andgenetics of the zinc metalloenzyme alcohol dehydrogen-ase (ADH) isozymes and to isolate and characterizepharmacologically active compounds from plants withpreventive or therapeutic effects on alcohol intoxication.Applicants should have experience in the isolation ofADH or related isozymes from human and animal tissuesand in the determination of the phenotypes of humanADH isozymes; culture of mammalian cells; workingwith laboratory animals; receptor binding assay tech-niques; ion and ligand uptake experiments; kinetic analy-sis and chemical characterization of metalloenzymes.Applicants should also have knowledge of identifyingherbs with preventive or therapeutic effects on alcoholintoxication and experience in the extraction and purifi-cation of pharmacologically active materials from plants.Requirements include Ph.D. in biochemistry and 6 to 8years of related research experience. Salary: $30,000 to$35,000. Send r&sumes to: CBBSM, Harvard MedicalSchool, 250 Longwood Avenue, Boston, MA 02115.Attention: Charles Alongi.

ASSISTANT PROFESSORMOLECULAR NEUROBIOLOGY

CASE WESTERN RESERVE UNIVERSITYThe newly established Center for Neurosciences at

Case Western Reserve University School ofMedicine hasa tenure-track opening at the assistant professor level fora person using molecular biological techniques to studyneural function. Candidates should have a strong back-ground in molecular biology, at least 2 years of postdoc-toral research experience, and should be ready to start anindependent research program. Renovated laboratoryspace and start-up funds will be available. Teachingduties will involve lecturing on the neurosciences tograduate and medical students. The Center for Neurosci-ences currently includes six primary faculty appointmentsand will expand over the next several years to approxi-mately twice that size. In addition, more than fifteenneuroscientists with appointments in other departmentsplay an active role in the research and teaching activitiesof the Center. The research interests of the currentfaculty are focused on neuronal development and onneuronal plasticity in adult organisms. Interested candi-dates should send their curriculum vitae, a briefsummaryof their future research plans, and the names of fourreferences to: Dr. Story C. Landis, Center for Neuro-sciences, Case Western Reserve University School ofMedicine, 2119 Abington Road, Cleveland, OH44106-2333, by 18 April 1989. Case Western ReserveUniversity is an Affirmative Acion/Equal OpportunityEmployer.

ASSISTANT PROFESSOR, TOXICOLOGY. TheDepartment of Physiological Sciences of the Universityof Florida, College of Veterinary Medicine, is seekingapplicants for a tenure-track assistant professor positionin toxicology. Preference will be given to an individualwith demonstrated experience in molecular or biochemi-cal toxicology. The incumbent is expected to develop aproductive research program in association with theCenter for Environmental Toxicology and participate ininstruction of toxicology. Interested applicants shouldhave a Ph.D. degree in toxicology, pharmacology, or arelated field. Salary will be commensurate with profes-sional and academic credentials and experience.

Applicants should send curriculum vitae, a statementof professional goals, and names of three potentialreferences to: Dr. S. F. Sundlof, Search CommitteeChairperson, Position VM-8811, University ofFlori-da, Box J-137, Gainesville, FL 32610. Applicationdeadline is 30 April 1989. An Equal Opportunity/Afirma-tive Action Employer.

ASSISTANT RESEARCH SCIENTIST. To par-ticipate in a research program on the cellular and molecu-lar genetic manipulation of cereal/grass species. Ph.D.with 3 to 4 years of postdoctoral experience and strongbackground in cell culture and the use of recombinantDNA techniques in cereal and grass species. Salary:$30,918 per annum plus retirement and health insurancebenefits. Send curriculum vitae, transcripts, copies ofrelevant publications, a statement of research interests,and arrange for four letters ofrecommendation to be sentto: Professor Indra K. Vasil, 511 Carr Hall, Universi-ty ofFlorida, Gainesville, FL 32611. Telephone: 904-392-1193; FAX: 904-392-6479, before 30 April1989. Equal Opportunity/Affirmative Action Employer.

POSITIONS OPEN

ASSISTANT OR ASSOCIATE PROFESSORTENURE-TRACK POSMIION

DEPARTMENT OF OTOLARYNGOLOGYThe Otological Research Group is seeking a research

biochemist with a background in carbohydrate/proteinbiochemistry with an emphasis on receptors, or celladherence relative to developmental biology, to developa biochemical/molecular biological program in the De-partment of Otolaryngology. AdditionaI skil/knowledgeof molecular biology desirable. Individual will participatein a team effort with a group of researchers studying eardisease. Salary commensurate with experience. Postdoc-toral experience required. Send curriculum vitae withthree professional references to: Ms. Teresa Martin,The Ohio State University, Otological Research Lab-oratories, 456 West 10th Avenue, Room 4331, Co-lumbus, OH 43210.

University of California, San Diego (UCSD), Schoolof Medicine is seeking outstanding candidates to filltenured-track positions at the ASSISTANT TO FULLPROFESSOR levels. Demonstrated creativity and pro-ductivity in the field of molecular biology as applied toneurosciences are an essential criteria for appointment.The positions require teaching at the graduate andmedical school un ergraduate levels. Opportunities existfor collaborative research with the broad, interdisciplin-ary Neurosciences Group at UCSD and associated insti-tutions. Salary will depend on qualifications of theapplicants. All applications received by 20 May 1989 willreceive thorough consideration. Send curriculum vitae,bibliography, and names and addresses of five referencesto: Dr. Robert Katzman, Department of Neurosci-ences, M-024, University ofCalifornia, San Diego, LaJolla, CA 92093. The University of California is an EqualOpportunity/Affirmative Action Employer.

UNIVERSITY OF MARYLANDASSOCIATE DIRECTOR

AGRICULTURAL EXPERIMENT STATIONAssist in the development of programs, budgets, fund-

ing initiatives, and the allocation and control of re-sources. Headquarters at the University of Maryland atCollege Park, with nine field locations throughout Mary-land. Eamed doctorate and qualification for appointmentat full professor rank in an academic department re-quired. Exemplary research background, a record ofcompetitive grantsmanship, quality publications, experi-ence in graduate education and, preferably, administra-tive experience. Salary commensurate with qualificationsand experience. This position will be filled as soon as aqualified candidate is identified. Closing date for nomi-nations and/or applications is 1 May 1989. Applicationsmust be accompanied by curriculum vitae. Three refer-ence letters should be sent directly to the Chair, SearchCommittee. All correspondence should be addressed to:Dr. Sashi Mohanty, Chair, Search Committee, Re-gional College of Veterinary Medicine, Room 3222,Chemistry Building, University ofMaryland, CollegePark, MD 20742. The University of Maryland is anAffirmative Action/Equal Opportunity Employer.

ASSOCIATE DIRECTOR/ASSOCIATE DEAN.The University of Vermont is seeking an AssociateDirector of the Extension Service and Associate Dean ofthe Division of Agriculture, Natural Resources, andExtension. This person is responsible to the Director ofthe Extension Service for the day-to-day management ofthe Extension Service, including all programming, bud-geting, human resources and related activities, and wlllact as the liaison with other units within and outside theUniversity to enhance integration of research and out-reach education. Candidates must have successful admin-istrative and human resource management experienceand a strong commitment to outreach education andresearch. An earned Ph.D. in a research discipline isrequired. Professional experience in the Extension Ser-vice is desirable. Applicants should submit a letter ofapplication, a current curriculum vitae, a list of publica-tions, evidence of successful leadership and effectivecommunications, a statement of professional goals andphilosophy, and a list offive names of referees. Nomina-tions and applications should be sent to: Dr. Lorraine P.Berkett, Chair, Extension Associate Director SearchCommittee, Department of Plant and Soil Science,University ofVermont, Burlington,VT 05405-0082.Deadline for receiving application and supporting mate-rial is 2 May 1989. The position will be available on orbefore 1 September 1989.

SCIENCE, VOL. 2431502

POSITIONS OPEN

ASSOCIATE IN CLINICAL RESEARCHDEPARTMENT OF SURGERY

BRIGHAM AND WOMEN'S HOSPITALBOSTON, MASSACHUSETTS

Division of Cardiac Surgery at Harvard MedicalSchool and Brigham and Women's Hospital has anopening for a clinical research associate. Applcant shouldhave experience with data entry, and basic programnuingskills to head up large data bank for coronary arterysurgery. Excellent wages and benefits.Send resumr to:

Lawrence H. Cohn, M.D.Chief, Division of Cardiac SurgeryBrigham and Women's Hospital

75 Francis StreetBoston, MA 02115

ASSOCIATE IN PHYSIOLOGYUNIVERSITY OF IOWACOLLEGE OF MEDICINE

Applications are invited for faculty positions at theassociate (non-tenure) level. Individuals whose interestscoincide with existing faculty strengths in cellular andmolecular aspects of endocrine regulation, nervous sys-tem signalling or membrane structure and function areparticularly encouraged to apply. Candidates should havethe Ph.D. or equivalent degree and at least 2 years ofpostdoctoral research experience. Please submit a letter ofapplication, with curriculum vitae, three reprints ofrecent experimental work, and names of at least threereferences, to:

Dr. Robert E. FellowsDepartment of Physiology and Biophysics

The University of Iowa5-660 Bowen Science Building

Iowa City, IA 52242The University ofIowa is an Equal Opportunity/Affirmative

Action Employer. Women and minorities are encouraged toapply.

ASSOCIATE IN RESEARCHDEPARTMENT OF SURGERY

HARVARD MEDICAL SCHOOL ANDBRIGHAM AND WOMEN'S HOSPITAL

BOSTON, MASSACHUSETTSDivision of Cardiac Surgery at Harvard Medical

School and Brigham and Women's Hospital has anopening for a research associate in cardiac surgical re-search. Applicant should have experience with in-vivoand in-vitro experimentation, chronic animal prepara-tions and basic cardiac research techniques includingisotopic blood flow measurement, cardiac biochemistryand ultrasonic crystals. Candidate should have a Ph.D.,or M.D./Ph.D. in cardiovascular physiology, pathology,or related field and capacity for interdisciplinary researchand growth. Please send resume and references to:

Lawrence H. Cohn, M.D.Chief, Division of Cardiac SurgeryBrigham and Women's Hospital

75 Francis StreetBoston, MA 02115

BIOLOGIST: Assistant professor, tenure-track. Start1 September 1989. Teach developmental biology, genet-ics, course in specialty. Participate in general courses formajors and non-majors. Opportunity for research. Ph.D.required. Letter of application, evidence of teachingpotential, curriculum vitae, and three reference letters by14 April 1989 to: Dr. Tom Frederick, Biology Depart-ment, Rochester Institute of Technology, 1 LombMemorial Drive, Rochester, NY 14623. AfirmativeAction/Equal Opportunity Employer.

BIOLOGISTS. Two 1-year leave/sabbatical replace-ments beginning fall 1989. We seek broadly trainedbiologists able to teach at least two of the following:genetics, general biology for non-majors, invertebratezoology, developmental biology, introductory zoology.It is probable that the positions will be filled with onefutl-time and one three-quarter time appointment. Sendletter of application, curriculum vitae, transcripts, andthree letters of reference to: Dr. Larry H. Jones, Chair,Biology Department, The University of the South,Sewanee, TN 37375. Application review will begin 30March 1989. Equal Opportunity Employer. Women andminorities are encouraged to apply.

BIOCHEMISTA Midwest manufacturer of specialty ingredients for

the animal feed industry seeks a biochemist to join itstechnical service group. The position involves travelingwith the company's sales force to affect technical trainingin the field, and to meet with customers. The individualwill also coordinate field experiments with various uni-versities, and writing of technical/sales bulletins. Thisposition involves 60% travel in the United States andabroad. The successful candidate will possess excellentverbal and written communication skills and enjoy com-municating science to the feed industry. The positionrequires a Ph.D. in biochemistry or related field. Anexcellent compensation package is offered. U.S. citizen-ship required.

Please submit resumes to: J. W. Harms, ExecutiveDirector of Sales and Marketing, Kemin Industries,Inc., P.O. Box 70, Des Moines, IA 50301.An Equal Opportunity Employer.

BIOLOGICAL PHYSICSCORNELL UNIVERSITY

SENIOR RESEARCH ASSOCIATE for positionas supervising scientist for the Developmental Resourcefor Biophysical Imaging and Opto-electronics. Will haveoperating responsibility for the resource laboratories andample opportunities for research applying modem physi-cal optics to the molecular biophysics of cellular dynam-ics. Current emphasis on electro-optical microscopicimage acquisition, digital image analysis, non-linear op-tics, photolysis and fluorescence photochemistry, confo-cal imaging, picometer imaging interferometry. Ph.D. inexperimental biophysics, optical or chemical physics orbiophysical chemistry should be appropriate. This posi-tion carries laboratory management responsibility as wellas research opportunity for interdisciplinary researchwith collaborating biophysicists and biologists. Somepostdoctoral experience desirable.A POSTDOCTORAL RESEARCH ASSOCIATE

position is also available in the Developmental Resourcefor Biophysical Imaging and Opto-electronics for re-search, innovative biophysical instrumentation develop-ment and opportunities for interdisciplinary research mmolecular and cellular biophysics.Send resume, statement of research interests, names of

three referees or letters ofrecommendation to: ProfessorWatt W. Webb, Cornell University, Applied andEngineering Physics, Clark Hall, Ithaca, NY 14853-2501. Cornell University is an Equal Opportunity/Affirma-tive Action Employer.

BIOLOGIST. A tenured-track position at the rank ofassistant professor is available August 1989. Instructionalresponsibilities emphasize the presentation of an eveningoffering of introductory biology fall and spring semestersand an opportunity to offer graduate courses. A Ph.D. isrequired with teaching experience preferred. Candidatesare expected to develop a productive research program.Send curriculum vitae, a description ofresearch plans andnames and addresses of three references to: Harold G.Marshall, Chairman, Department of Bioklgical Sci-ences, Old Dom n University, Norfblk, VA 23508.Review process will begin 1 April 1989 and will remainopen until a qualified candidate is found. An AffirmativeAcion/Equal Opportunity Institution and requires compliancewith the Immigration Reform and Control Act of 1986.

CHEMICAL ENGINEERINGMASSACHUSETTS INSTITUTE

OF TECHNOLOGYApplicants are invited for a tenure-track FACULTY

POSITION in the Department of Chemical Enieer-ing. Applicants should have a Ph.D. in chemical engi-neering or a closely related field, should have demon-strated excellence in academic research, and should have astrong interest in teaching graduate and undergraduatechemical engineering. Applicants are preferred with in-terest in either polymer science and engineering orchemical reaction engineern'g applied to processing ofadvanced materials. ExceptionaI candidates for seniorlevel positions will be considered. Send resume includingthe names of at least three references, graduate transcriptsand a description of research interests to: Dr. Robert A.Brown, Head, Department ofChemical Engineering,Massachusetts Institute of Technology, Cambridge,MA 02139. Material should be received by 15 April1989. MIT is an Equal Opportunity/Affirmative AcionEmployer and encourages applications from minorities andwomen.

CARDIOVASCULAR FACULTY POSMONApplications are invited for a tenure-track faculty

position in the area of cardiovascular physiology andcontrol of circulation at the level of associate or fullprofessor. Candidates must have a Ph.D. or M.D. degreeand sufficient postdoctoral teaching and research experi-ence commensurate with the expected level of appoint-ment. This position will complement an interactivegroup offacuy with strong commitment to the study ofcellular and integrative aspects of neural and endocrinecontrol of physiological systems. The successful candi-date will be expected to develop and maintain a strongindependent research program and to participate inteaching the medical and graduate students. Interestedapplicants should submit by 1June 1989 curriculumvitae, statement of research goals and accomplishments,summary of teaching experience, and the names of fourreferences to:

Esmail Koushanpour, Ph.D.Chairman, Search CommitteeDepartment of Physiology

Northwestern University Medical School303 East Chicago Avenue

Chicago, IL 60611Telephone: 312-908-8220/7991

Northwestern University is an Afirmative Action/EqualOpportunity Employer. Hiring is contingent upon eligibility towork in the United States.

CELL BIOLOGIST/ELECTRON MICROSCO-PIST. The Department of Physiology and Neurobiolo-gy, University of Connecticut, Storrs, Connecticut, issoliciting applications for an anticipated tenure-trackposition at the associate/full professor level beginning 1January 1990. A Ph.D. or M.D. degree is necessary. Theposition will require participation in the Department'sgraduate program, development of an independent re-search program, and supervision of a well equipped andstaffed biological EM facility and its service function.Proficiency in TEM and SEM instrumentation and appli-cation of ultrastructural and analytical methods to bio-logical samples is required. Research interests shouldcomplement existing faculty research programs in renalphysiology, endocrinology, and neurobiology. Possibleareas of interest include, but are not limited to, ultra-structural studies of membrane transport, secretory pro-cesses, synapses, cell motility, determinants of cell shape,and cell-cell or cell-substrate interactions. Qualified womenand members of minority groups are encouraged to apply.Curriculum vitae, including a description of researchinterests, and names ofthree references should be sent to:Dr. Guillermo R. Pilar, Head, Department of Physi-ology and Neurobiology, Box U42, The UniversityofConnecticut, 75 North Eagleville Road, Storrs, CT06269-3042. Salary negotiable according to qualifica-tions. Screening will begin 14 April 1989, and willcontinue until the position is filled. Affirmative Action/Equal Opportunity Employer. Search #9A162.

CELLULAR BIOLOGIST (IMMUNOLO-GIST)-Tenure-track assistant professorship starting fall1989. We seek a cellular biologist with expertise inimmunology who will teach upper level and graduatecourses in these areas, and share teaching general biolo-gy. Research opportunities include a modem laboratoryand much equipment. Send curriculum vitae and threeletters of reference by 17 April to: Dr. Alfred Chaet,Search Committee Chairperson, Department of Biol-ogy, The University ofWest Florida, Pensacola, FL32514. Equal Opportunity/Affinnative Action Institution.

National Park Service, Indiana Dunes National Lake-shore, Porter, Indiana, invites applications for CHIEFSCIENTIST. Incumbent is responsible for all park re-search activities in the fields of geology, soil science,hydrology, air quality, zoology, botany, and fire ecologyas well as personnel and administrative matters of thedivision. A , conducts studies in own area of expertise.Must be a U.S. citizen. Ph.D. or equivalent combinationof professional experience and graduate education re-quired in the major areas of ecological inquiry. Salarycommensurate with experience. Further details from:Glen Alexander, Indiana Dunes. Telephone: 219-926-7561, extension 411. The National Park Service is anEqual Opportunity/Afinmative Action Employer.

PERSONNEL PLACEMENT 150317 MARCH I989

POSITIONS OPEN POSITIONS OPEN

POSITIONS OPEN

OIMMUNOMEDICSM.SJPH.D.-CHEMIST

Immunomedics, the pioneer company in the use ofantibodies for cancer imaging and therapy, is expanding itsDeparment of Radiochemistry and Immunochemistry.

Applicant: M.S./Ph.D.level with expertse in organicsynthesis and experience in one or more of the following:analytical chemistry, radiochemistry, or immunochemistry.We offer an attractive employment package including

paid health/dental, a 401K retirement plan and theopportunity for stock and stock option merit rewards.

Please send curriculum vitae, slary requirements, andcareer objectives to:

Personncl DirectorImmunomcdics, Inc.150 Mt. Bethel Road

CN 4918Warren, NJ 07060

An Equal Opportunity Employer M/F.

CHIEF, DIVISION OF ONCOLOGY/HEMA-TOLOGY-Full-time academic appointment available atSouthern Illinois University School of Medicine. Asso-ciate Professor or Professor of Medicine, depending onexperience. Internal Medicine and Oncology/Hematolo-gy certification or equivalency is required. Teaching andpatient care responsibilities with a strong interest inclinical research. Send resumes to: Oliver E. Owen,M.D., Professor and Chairman, Department of Inter-nal Medicine, SIU School of Medicine, P.O. Box19230, Springfield, IL 62794-9230. SIU School ofMedicine is an Equal Opportunity/Affirmative Action Employ-er. This position will be open until April 1989 or untilfilled.

DEVELOPMENTALPHYSIOLOGIST/GENETICIST

TENURE-TRACK ASSISTANT PROFESSORThe Department of Biological Sciences at the Univer-

sity of Windsor, is seeking a person with a researchprogram in developmental physiology or developmentalgenetics of animal systems. Preference will be given to anindividual working on aquatic organisms. The successfulcandidate will be expected to obtain external researchfunding. Duties will include: participating in the teach-ing of undergraduate animal physiology courses, andgraduate courses in area of specialization; and the direct-ing of graduate students at M.Sc. and Ph.D. levels. Thisposition is available 1 July 1989. Later start date may benegotiated.

Please send application by 15 April 1989 to:Dr. M. L. Petras

Department of Biological SciencesUniversity of WindsorWmdsor, OntarioCanada, N9B 3P4

The University of Windsor offers Equal Opportunities toqualified female and male candidates. Women are particularlyencouraged to apply.

In accordance with Canadian immigration requirements priori-ty will be given to Canadian citizens and permanent residents.

DIRECTORIDAHO WATER RESOURCESRESEARCH INSTITUTEUNIVERSITY OF IDAHO

MOSCOW, IDAHORequircd qualifications include: a Ph.D. and ability to

qualify as a tenured professor in an academic department;experience in program initiation, budgeting and person-nel management; ability to communicate orally and inwriting; and experience in obtaining and administeringresearch grants and contracts. Full-time 12-month posi-tion. Requires travel. Salary is competitive and commen-surate with qualifications.Send detailed resume and the names ofthree references

to: Peggy Hammel, Sccretary, IVVRRI Search Com-mittee, 106 Morrill Hall, University of Idaho, Mos-cow, ID 83843. Telephone: 208-885-6429. Searchand selection procedures will be closed when qualifiedcandidates have been identified, but not earlier than 21April 1989. Equal Opportunity Employer/Affirmative ActionInstitution.

DEPUTY DIRECTOR GENERAL-The Interna-tional Center for Living Aquatic Resources Management(ICLARM), which carries out research in aquaculture,capture fisheries and coastal area management in tropicaldeveloping countries, is seeking a Deputy with a strongbackground in the aquatic or agrcultural sciences. TheDeputy's main roles will be to foster relationships withdonors and represent the Center internationally. Sendapplication as soon as possible, including addresses andtelephone numbers of three references to: DirectorGeneral, ICLARM, MC P.O. Box 1501, Makati,Philippines, or Fax: (63-2) 816-3183.

DIRECTOR AND PROFESSOR, School of Natu-ral Resources and Associate Dean, College of Agricul-ture, The Ohio State University. Applications and nomi-nations are invited for the position of Director of theSchool of Natural Resources, which offers the onlycomprehensive, multi-disciplinary undergraduate andgraduate academic programs in natural resources inOhio. At present, there are 27 full-time faculty andapproximately 250 undergraduate and 45 graduate stu-dents in the School. The Director, who reports to theVice President and Executive Dean of the College ofAgriculture, has fiscal and administrative responsibilityfor all instructional, research, and public service/exten-sion programs in the School. Qualifications for theposition includc an earned doctorate and a record ofresearch and teaching consistent with appointment as atenured full professor. Candidates shall have demonstrat-ed administrative experience and leadership ability, pref-erably in a multi-disciplinary academic unit. Candidatesshall also have the ability to communicate effectively.Nominations and cxpressions of interest will bc receiveduntil 15 April 1989 or until suitable candidates have beenidentified; the position is available 1 Septembcr 1989. Aposition descnption and application materials will beprovided. Address correspondence to: Dr. James H.Brown, Chair, SNR Director Search Committee, 210Kottman Hall, Ihc Ohio State University, Colum-bus, OH 43210-1085 or call: 614-292-2265. TheOhio State University is an Equal Opportunity/AfinnativeAction Employer.

YALE UNIVERSITYDIRECTOR

SCIENCE AND ENGINEERINGCOMPUTING FACILITY (SECF)

Yale University invites applications from individualswith experience supporting the use of distributed com-puters in a forefront academic institution. The Directorwill supervise a small staffof technical personnel and willprovide technical advice and assistance to the faculty inthe science and engineering departrnents and to theOffice of the Provost on the instructional and researchapplications of the full range of computers (micros tosupers). The Director also represents the interests of ourscientific computing community with vendors and withvarious consortia (e.g., DECUS, Apple University Con-sortium, the national supercomputer centers). Applicantsshould have a doctoral degree or equivalent in some fieldof science or engineering. The possibility exists forcombinng this position with a teaching or researchappointment in the science or engineering departmentthat corresponds most directly with the candidate's inter-ests. Review of candidates will begin upon receipt ofapplications or nominations. To be considered applica-tions must be received by 1 May 1989. Send r6sumrewiththe names of three references to: Professor R. Apfel,Chair, SECF Search Committee, Council of Engi-neering, P.O. Box 1968 Yale Station, Yale UniversityNew Haven, CT 06520. Yale University is an AffirmativeAction/Equal Opportunity Employer and encourages applica-tions from members of minority groups.

EASTERN KENTUCKY UNIVERSITYECOLOGIST

One-year visiting position or sabbatical leave replace-ment beginning 15 August 1989, teaching biology andecology to students not majoring in the sciences. Ph.D.required. Send curriculum vitae, photocopies of all tran-scnpts, and three letters of reference to: Bruce MacLar-en, Department ofNatural Science, Easten KentuckyUniversity, Richmond, KY 40475 by 7 April 1989.Telphone: 606-622-2319.

Employment eligibility verification required, ImmigrationReform and Control Act of 1986. Eastern Kentucky Universityis an Equal Opportunity/Affirmative Action Employer.

EDUCATION-FACULTY POSITION-MI-CRO-FLUID DYNAMICS-Thc Applied Ocean Sci-encc Program at the University of Delaware's Coilege ofMarine Studies invites applications for a tenure-trackfaculty position to start anytime after 1 Scptember 1989.Requires Ph.D. in the physical sciences or cngineeringfields. Strong background in theoretical and experimen-tal work on underwater fluid dynamics desirable. In-volves teaching at the graduate level and development ofan independent, funded research program in micro-fluiddynamics including interactions at sold boundaries. Op-portunity to interact with ongoing research in: remotesensing, electromagnetic and sound wave interactionwith suspended particles, theoretical and numericalmethods in acoustic wavc propagation, air/sea interac-tions, corrosion and fouling. Send resume with namesand addresses of three references to: Dr. Stephen C.Dexter, Chairman, AOS Search Committee, Collegeof Marinc Studies, University of Delaware, Lewes,DE 19958. Closing date: 1 June 1989. The University ofDelaware is an Equal Opportunity Employer which encouragesapplications from qualified minority groups and women.

ENDOCRINOLOGIST-Diabetologist/Nutrition-ist Board-certified physician needed for a fuil-time aca-demic appointment with Southern Illinois UniversitySchool of Medicine. This position is needed to expandthe current metabolic, endocrine, nutritional and diabe-tes center. Rank and salary to be negotiated. Researchand service activities are integrated with an innovativeteaching program. Send resumes to: Oliver E. Owen,M.D., Professor and Chairman, Departmcnt of Inter-nal Mcdicine, Southern Illinois University School ofMedicne, P.O. Box 19230, Springfield, IL 62794-9230. This position will be open until April 1989 oruntil filed. SIU is an Equal Opportunity/Afirmative ActionEmployer.

ENVIRONMENTAL BIOLOGISTECOTOXICOLOGY

The Department of Biology, University of NorthernIowa, invites applications from individuals with a Ph.D.degree, with postdoctoral or equivalent experience pre-ferred, for a new tenure-track position effective August1989. The applicant's research should address the toxiceffects of air, water, or soil-borne pollutants and/orhazardous substances upon organisms in ecological sys-tems. The research should invite participation by under-graduate and M.A. students. Teaching responsibilitiestypically include three courses per year from the follow-ing: specialties, introductory biology, and general educa-tion. Research and consulting opportunities exist withthe on-campus Center for Safe and Economic Manage-ment of Solid Waste and Hazardous Substances. Excel-lence in both teaching and research is expected. Salary iscompetitive and faculy rank is open. Applicants shouldsend curriculum vitae, graduate transcripts, a statementof interests and goals in both teaching and research,relevant reprints, and four letters of reference by 15 April1989 to:

Dr. E. Russell TePaskeDepartment of Biology

University of Northern owaCedar Falls, IA 50614-0421

The University of Northern Iowa is an Equal OpportunityEducator and Employer with a comprehensive plan for Affirma-tive Action. The University specifically invites and encouragesapplications from women and minorities.

FACULTY POSITION IN X-RAYCRYSTALLOGRAPHY ORSTRUCTURAL BIOPHYSICS

BAYLOR COLLEGE OF MEDICINEWe invite applications for two tenure-track positions

in macromolecular x-ray crystallography and related areasof structural and theoretical biophysics. The departmentis seeking outstanding scientists who are committed toestablishing productive research programs in the expand-ing structural biophysics group. Preference will be givento applicants at the assistant professor level, but moresenior individuals will be considered. A new core x-raylaboratory, equipped with state-of-the-art instruments,has been established. Applicants should send curriculumvitae, three representative publications, a statement ofFresent and future research interests, and have threcetters of reference sent to: Dr. F. A. Quiocho, HowardHughes Medical Institute and Department of Bio-chemistry, Baylor College ofMedicne, Houston, TX77030. An Equal Opportunity Employer.

SCIENCE, VOL. 243If504

POSITIONS OPEN POSITIONS OPEN

POSTDOCTORAL POSITIONS.........~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~...............

BOEHRINGER INGELHEIM PHARMACEUTICALS, Inc. is engaged in thediscovery, development, manufacture and marketing of novel therapeutic agents.Our commitment to research has created the opportunity for the followingpostdoctoral positions in our drug discovery programs.

ei Ittmmunologist . .............EThis individual will conduct research in the field of neutrophil or lymphocyteadhesion or adhesion molecule related functions. RESPOND TO DEPT. JC-1S-PDRR

XW~~~~~~~~~~~~~~~~~~~~~~~~... ....-This position requires an interest in cancer and/or viral immunology. Theincumbent will perform important research projects in this area. RESPOND TODEPT. JC-1S-PDVM

.vBochmist_______________________Candidates should have a background and interest in enzymology, physicalorganic chemistry or kinetics. Research goals will be to investigate the kinetics,specificity and mechanism of viral proteases. RESPOND TO DEPT. JC-1S-PDMSBOEHRINGER INGELHEIM offers a competitive salary and benefits package,modern and fully equipped laboratories and the opportunity to apply youreducation and experience to challenging areas of research. Our Research andDevelopment Center is situated in a very desirable area of SOUTHWESTERNCONNECTICUT (in DANBURY).Candidates interested in these positions should send a curriculum vitae, alongwith the names of three references, indicating appropriate dept. code, to:BOEHRINGER INGELHEIM PHARMACEUTICALS, Inc., 90 East Ridge,PO. Box 368, Ridgefield, CT 06877. We are an equal opportunity employer mrf h v.

oehrimneratt Ingelheim

.. . .

Medical AffairsOfficer

T CELL SCIENCES, INC., is a health care com-pany engaged in the development and marketingof therapeutic and diagnostic products. Positionsat T CELL SCIENCES include a career-enhancingenvironment and offer the opportunity to interfacewith internationally recognized scientists in con-veiling their discoveries into products.We are seeking an experienced Medical AffairsOfficer to participate in planning, conducting andevaluating a clinical trial program involvin9recombinant product(s) in potential therapies formyocardial injury and events involving tissuedamages. Clinical trials for future products willinclude autoimmune diseases and certaincancers. The individual will be responsible foridentitying and coordinating multicenter clinicaltrials; coordinating the development of clinicalprotocols; reviewing and interpreting all safetyand efficacy issues of the therapeutic agentsunder evaluation; and preparing clinicalstudy reports, IND updates and NDAsubmissions.The successful candidate will have anM.D. degree (Board Certified in InternalMedicine) with additional training in one ormore of the following disciplines: immunol-ogy, cardiology, infectious diseases andrheumatology; 3 or more years of pharma-ceutical drug trial experience; knowledgeof regulatory affairs; and exceptionalorganizational, communications and man-agement skills.Interested candidates please forwardresume/C.V., salary requirements anddescription of career goals/publica-tions or abstracts to Paula R. Freeman,T Cell Sciences, Inc., 38 Sidney St.Cambridge, MA 02139.

TCELLSENCES

Imnportcmt ContributionsToAn Essendal Effort.

If you've been looking for an organization where your contributions will make astrong and positive impact, may we suggest The MITRE Corporation. A not-for-profitorganization providing expert systems engineering solutions to military and civilagencies of the U.S. Government, we are currently providing technical support tomanage the nation's hazardous waste problems for the EPA and to meet the man-dates of the Defense Environment Restoration Act. These are the essential efforts thatcan make excellent use of your proven expertise.

IoxicologistsMcLean, VA & San Antonio, TXWe currently have openings at our Washington Center and our San Antonio Site forprofessionals with high levels of skill and dedication to provide quality assurance ofhuman health risk assessments performed by contractors on Air Force InstallationRestoration Sites. Specific responsibilities include evaluating work plans for ade-quacy of approach; reviewing risk assessments for accuracy, completeness andvalidity of conclusions; and analyzing expect risk reductions. You will assist the AirForce in coordinating activities with EPA regional and state offices to ensure regula-tory compliance. To qualify, you must have an advanced degree in Toxicology orrelated discipline, plus at least 3 years of experience in conducting chemical expo-sure and risk assessments, preferably at hazardous waste sites. Familiarity withCERCLA/SARA, the RI/FS process and EPA guidelines for conducting risk assess-ment at N PL sites is essential. Excellent communications skills a must.

Please submit your resume to N.S. Scott, The MITRE Corporation,7525 Colshire Dr., McLean, VA. 22102. U.S. Citizenship required. An EqualOpportunity Employer.

MSITRE____

NATIONAL INSTITUTESOF HEALTH

POST DOCTORALFELLOWSHIP

TRANSGENIC MICEExperience in molecular biol-

ogy to work in laboratory usingtransgenic mice to study thepathogenesis of viruses (e.g.,HIV and HSV) and autoimmunediseases. Initial appointment willbe for two years, with renewalson a yearly basis. Starting salaryrange, depending on experi-ence, is $24,000 to $40,000 peryear. The position is availableimmediately. Send CurriculumVitae and names of references toDr. Lois Salzman, Deputy Di-rector, Intramural ResearchProgram, National Institute ofDental Research, National In-stitutes of Health, 9000 Rock-ville Pike, Building 30, Room121, Bethesda, Maryland20892.

NIH is an Equal OpportunityEmployer

:::::. .. -, ..........X. '...

I

POSITIONS OPEN

ENDOCRINOLOGIST/PHYSIOLOGIST:KRUG International, support contractor for the Bio-medical Labs at NASAJJSC, seeks a Ph.D. with researchexperience in fluid and electrolyte regulation. The candi-date's research will be expected to focus on hormonaland/or biochemical mechanisms of acute and chronicvolume changes. Training on human clinical researchwith a physiological emphasis is preferred. Applicantsshould submit curriculum vitae and four references to:June E. Richmond, Human Resources Manager,KRUG International, P.O. Box 58827, Houston, TX77258. An Equal Opportutnity Employer/employment eligibil-ity verificationi required.

FACULTY POSITIONANALYTICAL MICROSCOPIST/

MATERIALS SCIENTISTApplicants are sought for a full-time tenure-track

position at the assistant professor level. A strong back-ground in analytical electron microscopy and a Ph.D. inmaterials science or a related discipline is required.Candidates should be interested in teaching undergradui-ate and graduate courses and in developing a strongresearch program. Proposed starting date is negotiable.In order to ensure full considerations, applicationsshould be received by 1 May 1989.

Northwesteni is atn Affirmative Action/EqUal OpportunityEmployer. Hiring is continigenit upon eligibility to work itn theUntited States. Send resumr, publications and the names ofthree references to:

Professor L. D. MarksNorthwestern University

Department of Materials Scienceand Engineering

Evanston, IL 60208

FACULTY POSITIONSThe Department of Molecular Genetics, Biochemistry

and Microbiology announces the opening of sevcraltenure-track faculty positions. These are in the areas of!(i)human genetics, particularly for an individual currentlyinterested in genetic diseases affecting the cardiovascularsystem, (ii) protein chemistry, the utilization of genetictechniques to study structure-function, and (iii) molecu-lar immnunology. Appointments can be at any level.Generous space and start-up monies are available. Thecurrent department has 27 faculty and 50 graduatestudents and maintains core facilities in cell culture,recombinant technology including DNA sequencing,and transgenic mice production. Interested applicantsshould submit curriculum vitae, brief description ofanticipated research, and names of three qualified refer-ences to: Jerry B. Lingrel, Ph.D., Professor and Chair,Molecular Genetics, Biochemistry and Microbiology,University of Cincinnati College of Medicine, 231Bethesda Avenue, Cincinnati, OH 45267-0524.

The Utniversity of Cincinnati is ant Equal Opportunity!Affinnative Action Enployer.

FACULTY POSITIONS INAPPLIED MOLECULAR

BIOLOGY/BIOCHEMISTRYThe Department of Chemical and Biological Sciences

at the Oregon Graduate Center is expanding its biotech-nology program and invites applications for three facultypositions in molecular biology and protein engineering.We are interested in researchers in the fields of (i)molecular biology of yeast/fungi, (ii) molecular biology/biochemistry of prokaryotic soil microorganisms, and(iii) genetic engineering of proteins.Rank and salary are open. Investigators who value an

environment fostering excellence in research are encour-aged to apply.Minimum requirements: Ph.D., several years of post-

doctoral experience, and ability to develop a strongresearch program and graduate level courses in areas ofspecialty. Appointments will be made at the level ofassistant professor or higher depending on qualifications.Send curriculum vitae, a statement of research inter-

ests, and the names, addresses, and telephone numbers ofthree references to:

Dr. Michael H. Gold, Search Committee ChairDepartment of Chemical and Biological Sciences

Oregon Graduate Center19600 N.W. Von Neumann Drive

Beaverton, OR 97006-1999Equal Opportunity Employer.

POSITIONS OPEN

FACULTY POSMONBIOLOGICAL SCIENCES

COMPARATIVE PHYSIOLOGIST: Tenure-trackassistant professor position anticipated for fall 1989 at acomprehensive university of 25,000 students, located ina pleasant community 60 miles west ofChicago. A Ph.D.and postdoctoral experience are required. The successfulcandidate will be expected to maintain a vigorous re-search program, and direct graduate (M.S. and Ph.D.)students.

Candidates must have a broad knowledge of compara-tive physiology and preference will be given to a personwith a research program in invertebrate physiology. Toteach comparative physiology and participate in intro-ductory courses.Send curriculum vitae, statement of research goals,

three letters of reference and representative reprints by15 April 1989 to: Dr. Marvin J. Starzyk, Chairman,Department of Biological Sciences, Northern IllinoisUniversity, DeKalb, IL 60115-2861. Telephone:815-753-1753. The University is an Affirmative Action/Equal Opportunity Employer.

FACULTY POSITIONS IN X-RAYCRYSTALLOGRAPHY

The Department of Biological Chemistry and Molecu-lar Pharmacology at Harvard Medical School and theDana-Farber Cancer Institute are seeking applications tofill two positions at the assistant professor level to belocated at the Dana-Farber Cancer Institute. Applicantsshould be interested in using crystallographic methods tosolve problems in structural biology and biochemistryand should have an appropriate combination of relatedgraduate and postdoctoral level research experience. In-terested applicants should send an outline of futureresearch plans, curriculum vitae, bibliography and thenames of three to four references to: Professor Christo-pher Walsh, Chairman, Biological Chemistry andMolecular Pharmacology, Search Committee, Har-vard Medical School, 240 Longwood Avenue, RoomCL-213, Boston, MA 02115. Women and minorities areencouraged to apply. Harvard Uttiversity and Dana-FarberCancer Institute are Equal Opportunity Employers.The Bugher Foundation and the American Heart

Association have recently established a Center for Re-search on the Molecular Biology of the CardiovascularSystem at the University of Texas Southwestern TexasMedical Center. FELLOWSHIPS are available to peo-ple interested in establishing a career in basic cardiovas-cular research. Successful candidates will work 2 or 3years in laboratories at the Medical Center using thetechniques of molecular biology to study the cardiovas-cular system in health and disease. Selected candidateswill also be given the opportunity to extend their clinicaltraining in cardiology. Applicants holding M.D. orM.D./Ph.D. degrees should send copies of their curricu-lum vitae and two letters of reference from their mentorsto: Dr. J. Sambrook, Chairman, Biochemistry De-partment, UT Southwestern Medical Center, 5323Harry Hines Boulevard, Dallas, TX 75235-9038.Equal Opportunity/Affirmative Action Employer.HIV MOLECULAR BIOLOGIST, a junior level

research position in our Department of Virology andImmunology. We are seeking a scientist with researchinterests in the molecular biology ofhuman immunodefi-ciency virus (HIV) infection. Candidates should have aPh.D., M.D., or D.V.M. degree with accomplishmentsthat demonstrate the ability to maintain an independentresearch program. The appointee will complement thecurrent research in HIV infection conducted by Drs.Jonathan S. Allan, Tran C. Chanh, Jorg W. Eichberg,Patrick Kanda, and Ronald C. Kennedy. The programfocuses on vaccines, therapeutics, and pathogenesis ofHIV and SIV infection in nonhuman primate animalmodels.The Southwest Foundation for Biomedical Research is

a nonprofit, private research institution with a staff of45scientists and facilities for DNA sequencing, oligonucle-otide and peptide synthesis, hybridomas, electron mi-croscopy, flow cvtometry, and computer modeling. Italso has extensive nonhuman primate resources whichinclude baboons, rhesus monkeys, and chimpanzees.

Interested candidates should mail curriculum vitae,brief summary of research goals, and names and tele-phone numbers of three references to: Personnel Direc-tor (9), Southwest Foundation for Biomedical Re-search, P.O. Box 28147, San Antonio, TX 78284.Equal Opportunity Employer M/F.

POSITIONS OPEN

FOSSIL ENERGY POSTGRADUATE RE-SEARCH PROGRAM-Opportunities at EnergyTechnology Centers in Morgantown (West Virginia)and Pittsburgh. Research positions in the areas of physi-cal sciences, engineering, and mnicrobiology available.Degree within last 3 years required as is U.S. citizenshipor PRA status. Contact: Fossil Energy PostgraduateProgram, University Programs Division, Oak RidgeAssociated Universities, Box 117, Oak Ridge, TN37831-0117; Telephone: 615-576-3456.

HUMAN GENETICIST-STAFF COLLABORATOR

The National Institute on Alcohol Abuse and Alcohol-ism (NIAAA) invites applications for a staff collaboratorposition for a multi-site research program, "Collabora-tive Studies on the Genetics of Alcoholism CooperativeAgreement" to identify the genetic basis for alcoholism.The staff collaborator will have substantial scientificinput, in collaboration with participating grantees, in theplanning and conduct of the research programs. Appli-cants must have a Ph.D. or M.D. and have experience inconducting independent research in human genetics,genetic epidemiology or molecular genetics. This oppor-tunity may be filled as a competitive Civil Service ap-pointment (annual salary range $41,121 to $63,172) oras a visiting scientist or comparable appointment. Sendcurriculum vitae or request for information to: SueShafer, Ph.D., Acting Director, Division of BasicResearch, NIAAA, 6600 Fishers Lane, Rockville,MD 20857. Telephone: 301 443-2530. NIAAA is anEqual Opportunity Employer.

IMMUNOLOGY POSITION OPENINGAssistant/associate professor, tenure-track. Candidates

should be prepared to pursue a vigorous research program.Send curriculum vitae, statement of research interests, andthree letters ofreference to: H. K Ziegler, Ph.D., Depart-ment of Microbiology and Immunology, Emory Uni-versity School of Medicine, Atlanta, GA 30322. EqualOpportunity/Affirmative Action Employer.

INSTRUCTOR IN PHYSIOLOGY

Applications are invited from persons with a Ph.D.and/or M.D. for the position of instructor in physiology.The successful candidate will assist faculty in teaching ofphysiology to medical students and advanced courses ofendocrinology to graduate students. (S)he will performresearch with a neuroendocrine group investigating theroles played by peptides in central disorders and in small-cell carcinoma. Some teaching experience is highly desir-able. Preference will be given to candidates with abackground in small anima surgery, radioimmunoassay,high performance liquid chromatography and/or cellculture. Applicants should send curriculum vitae andthree letters of reference to: Dr. William G. North,Departnent of Physiology, Dartnouth MedicalSchool, Hanover, NH 03756. Dartmouth College is anEqual Opportunity/Afirmative Action Employer.

LABORATORY SUPERVISORHISTOLOGY LABORATORY SUPERVISOR.

Experienced ASCP certified histology technician withsupervisory experience is needed for a high volumeprivate pathology research laboratory located in theWashington, DC metro area near Dulles InternationalAirport. Salary commensurate with experience and quali-fications. Benefits package includes paid vacation, healthinsurance, 401K retirement plan, and much more. Inter-ested and qualified individuals should send resumes to:Experimental Pathology Laboratories, Inc., P.O. Box474, Herndon, VA 22070; or telephone: CynthiaBono at 703-471-7060 for information. Equal Opportu-nity Employer M/F/H/V.

MALARIA RESEARCH. TWO POSTDOCTOR-AL POSITIONS available 1 April 1989 to study: (i)interaction of malarial proteins with red cell membranes;(ii) regulation ofgene expression. Applicants with appro-priate training for either position contact or send curricu-lum vitae to: Dr. A. Kifejian, Public Health ResearchInstitute, 455 First Avenue, New York, NY 10016.Telephone: 212-578-0829. PHRI is an Equal Opportuni-ty Employer.

SCIENCE, VOL. 243I5o6

Opportunities in Drug MetabolismSmith Kline & French Laboratories, a leader in pharmaceutical research, is expanding its Drug Metabolism Department. We are seeking technically skilled and highlymotivated scientists from various backgrounds to participate in our drug discovery and drug development research. We have newly created openings in the following areas:

Protein/Peptide ChemistryOpportunities exist for those with interest and experience in the study of the metabolism, disposition and pharmacokinetics of therapeutic peptides and proteins. Thesuccessful candidates will design, conduct and interpret studies and prepare reports and publications of their findings. In addition, the successful applicant will establish aresearch program which will advance the understanding or peptide/protein metabolism. Positions are available for those with B.S., M.S. or Ph.D. degrees in proteinchemistry or related areas. Prior experience in the chemical and physical methods for protein isolation and structure determination is essential. Refer to position L0040.

Bioanalytical ChemistrySeveral positions are available in the Bioanalytical Methods Development Section. The primary function of these jobs will be to develop analytical methodology HPLC, GC,GCMS, RIA, etc., for the analysis of potential therapeutic agents in biological fluids. The successful candidates will be expected to develop or participate in thedevelopment of independent research programs in the area of novel 'trace" analysis. Positions are avaiable for those with B.S., M.S. or Ph.D. degrees in analyticalchemistry or related areas. Prior experience in the area of bioanalytical methods development and trace analysis is essential. Refer to position L0041.

PharmacokineticsChallenging positions are open for those with expertise in the areas of clinical pharmacokinetics, prectinical pharmacokinetics, toxicokinetics and in vitro kinetics. The

successful applicants will apply pharmacokinetics principles to the discovery and development of potential new therapeutic agents. Duties will include the design, conduct,interpretation and reporting of pharmacokinetic studies. Openings are available for persons with B.S., M.S., Ph.D. or Pharm.D. degrees in pharmaceutical chemistry or

related areas. Prior experience in the area of pharmacokinetics is essential. Refer to position L0042.

Mass SpectrometryThe Department has recently expanded the Mass Spectrometry Section and is seeking scientists with experience in running a mass spectrometer. The successful

candidate will work with senior staff in the structure elucidation of metabolic products of potential new therapeutic agents. Primary duties will include design of studies,generation of mass spectrometric data, interpretation of results, reporting of conclusions and maintenance of equipment. The successful candidates will have B.S. or M.S.degrees in chemistry or related areas with prior experience in running and maintaining a mass spectrometer. Refer to position L0043.

Based in a new, state-of-the-art research facllity in suburban Philadelphia near Valley Forge, SK&F provides a stimulating and challenging scientific environment in which

to grow and excel. We offer an attractive compensation/benefits and relocation package and support continuing education efforts. For confidential review, please forward

your C.V. and names of three references to: Liz McKendry, Associate Employment Administrator, Smith Kline & French Laboratories, Research and Development, P.O.

Box 1539, King of Prussia, PA 19406-0939. M/F/H/V.

Manager, Ophthalmic/Sterile Products

The Consumer Products Division of Pfizer, located in Parsip-pany, NJ, is recognized worldwide for its quality ophthalmic/sterile products such as Visine, and for proprietary over-the-counter health care products. This growth oriented divisionhas immediate challenges for a scientist with strong leader-ship abilities, a background in production and solid researchcapabilities.

In this key position, you will help develop new products andimprove existing ones. This will involve supervising bothchemists and research assistants in all aspects of productdevelopment, including animal and human studies, evalu-ative testing and product performance. You will also developtest methodologies, coordinate product stability programsand assist in cost savings programs. Your achievements willimpact directly on research, production, marketing and sales.

To qualify, you must possess a BS or MS in Chemistry or arelated science, and at least f ive years experience in ophthal-mic or sterile liquid dosage form development. A PhD wouldbe a plus.

Pfizer offers a competitive salary and excellent benefitspackage. For prompt consideration, please forward resumeand salary requirements in confidence to: A. J. Murphy,Personnel Director, Pfizer Inc., 100 Jefferson Road, Parsip-pany, NJ 07054. An equal opportunity employer.

Switzerland

'A

CHEMIST / BIOCHEMISTMAAG is the Agrochemical Division of Hoffmann-La Rochewith headquarters in Switzerland and subsidiaries in Franceand the USA. As part of our expansion program, we requirea Ph.D. chemist or biochemist with experience in analyticaltechniques (especially HPLC) to join our Metabolism Sec-tion in the Department of Registration and EnvironmentalStudies. Duties will include the study of the behaviour ofnew candidate plant protection compounds in plants, soiland water. Study reports are used to support the interna-tional registration of our successful research compounds.Industrial experience as well as experience in working withradiolabelled compounds (14C) would both be advantagesbut are not essential. Our laboratories are modern and fullyequipped. Dielsdorf is situated in pleasant, rural surround-ings about 10 miles outside Zurich. We hope to fill thisimportant position with a scientist who is interested inlaboratory work and who would thrive on the inter-discipli-nary nature of the position. The successful candidate willsupervise 1-2 lab. technicians.

Candidates with Swiss citizenship or who qualify for a SwissWork Permit "C" are eligible to apply. Please send adetailed CV to the Personnel Officer, Dr. R. MAAG AG, CH-8157 Dielsdorf, Switzerland. (Telephone: 01 1 41 1 855 1 1 1 1).

POSITIONS OPEN

MICROBIOLOGIST-ASSISTANT PROFESSOR

UNIVERSITY OF CALIFORNIA, DAVISThe Department of Food Science and Technology

seeks a microbiologist for a tenure-track position asassistant professor and assistant microbiologist in theAgricultural Experiment Station. The candidate will beexpected to use molecular or classical approaches indeveloping a research program that investigates microor-ganisms or microbiological problems of importance to.foods or food processing. Applicants will be selected forinterviews on the basis of research accomplishments,potential for developing a strong research program, andability to train, teach, and advise students in food scienceand related basic disciplines. Graduate training at Davisuses the Graduate Group system, and the appointeewould direct Ph.D. and M.S. students from the Microbi-ology, Food Science, Biochemistry, and/or GeneticsGraduate Groups, depending on research interests. Un-dergraduate teaching responsibilities will be coordinatedwith the four microbiologists currently in the Depart-ment and will be within the appointee's area ofspecializa-tion. A Ph.D. in microbiology or related field is required.Send curriculum vitae, publication list, statement ofresearch interests, and the names and addresses of fourreferences to: Dr. C. W. Price, Delartment of FoodScience and Technology, Universsty of California,Davis, CA 95616. To assure consideration, please sub-mit application by 1 May 1989. UC Davis is an EqualOpportunity/Affirmative Action Employer.

MOLECULAR ENTOMOLOGY-PLANT PROTECTION

BOYCE THOMPSON INSTITUTE ATCORNELL UNIVERSITY

The Boyce Thompson Institute at Comell Universityinvites applications for a tenure-track position in plantprotection at the level of ASSISTANT SCIENTIST.The Institute has an ongoing program in plant protec-tion which includes research projects on microbial patho-gens of insects and insect-plant interactions. The candi-date will be expected to establish a vigorous, independentresearch program that will combine the principles ofmolecular biology with the fundamentals of insect biolo-gy to develop novel strategies for plant protection.Applicants should have strong experience in basic molec-ular biology that could be applied to insect development,reproduction, and/or pathology of insects. Candidateswith records of achievement in postdoctoral positions ortheir equivalent will be considered. Send curriculumvitae, transcripts of college records, a list of three refer-ences, and a statement of research interests by 15 May1989 to: Dr. Richard C. Staples, Chairman, PlantProtection Search Conunittee, Boyce Thompson In-stitute, Tower Road, Ithaca, NY 14853.

OREGON HEALTH SCIENCESUNIVERSITY

CENTER FOR RESEARCH ONOCCUPATIONAL AND ENVIRONMENTAL

TOXICOLOGYNEUROTOXICOLOGICAL SCIENCES

Newly created, state-supported, multidisciplinary Cen-ter in neuroscience-rich environment seeks potential orestablished independent SCIENTISTS primarily toconduct basic research on molecular and cellular mecha-nisms underlying adverse actions of chemicals on themammalian nervous system. Special interest areas inxenobiotic-receptor-gene interactions, perturbations ofgene-product expression and their relationship to neuro-degenerative diseases. Other areas indude behavioraltoxicology; analytical and synthetic chemistry; chrono-toxicology; developmental neurobiology and mutagene-sis; geronto-neurotoxicology; immunoneurotoxicology;neuroepidemiology; molecular neurophysiology; molec-ular toxicogenetics; neuroendocrine and neurosensorytoxicolotoxicoxicognosy; and tumorgenesis. Ten scientistand staff scientist positions available (start-up 1989tol991) on term, tenure-track or tenure appointmentsequivalent to assistant, associate or full professor, de-pending on qualifications, experience and potential. Sala-ries competitive with other major universities, with50%+ generated from funded research. Submit fiullydeveloped application by 7 April 1989 to: Dr. P. S.Spencer, Director and Senior Scientist, Center forResearch on Occupational and Environmental Toxi-cology, Oregon Health Sciences University, P.O. Box8366, Portland, OR 97207-8366. Oregon Health Sci-ences University is an Equal Opportunity/Affirmative ActionEmployer.

POSITIONS OPEN

NEUROSCIENTIST-RESEARCH FACULTYPOSITION available. Duties include supervising gradu-ate students and postdoctoral fellows. The candidateshould have Ph.D. and/or M.D. degrees with at least 2years of postdoctoral experience in areas of physiologyand biophysics of mammalian cortical neurons and cir-cuits and mechanisms of epilepsy. Ability to competesuccessfully for extramural funds is essential. Applica-tions should include curriculum vitae and names of threereferences. Write to: Dr. Timothy A. Pedley, TheNeurological Institutc, 710 West 168th Street, NcwYork, NY 10032. Columbia University takes AffirmativeAcion to ensure Equal Opportunity.

NMR STAFF SCIENTIST position available in theDepartment of Neurology at Henry Ford Hospital.Areas of research include the application ofNMR to thestudy of human and animal brain metabolism and bloodflow with an emphasis on stroke, dementia, and Parkin-son's disease. The successful applicant will have a Ph.D.and at least 2 years of postdoctoral training in in vivoNMR, and will be encouraged to develop their ownresearch interests. The Department of Neurology, aNINCDS Center for Stroke Research, has two dedicatedresearch NMR systems; an 80-MHz whole-body and a400-MHz wide-bore system. The purchase and installa-tion of an additional whole-body 3.OT magnet isplanned for fall 1989. Other facilities include numerousbiochemistry labs and fully-equipped machine and elec-tronics shops. Resume shoutd be sent to: Dr. J. A.Helpem, Director ofNMR Research, Department ofNeurology, Henry Ford Hospital 2799 West GrandBoulevard, Detroit, MI 48202. Tclephone: 313-876-2620.

OCEANOGRAPHER. The Oceanographic Centerof Nova University intends to fill a faculty position in atleast one of the following areas: Experimental physicaloceanography, theoretical physical oceanography, fisher-ies biology. The successful applicant will have the Ph.D.degree in one of these disciplines or in a related area andwill have the ability to develop a rigorous, independentresearch program. Research projects will be supportedentirely by contracts and grants. To supplement researchsalaries, limited graduate teaching opportunities areavailable. Submit curriculum vitae and three referencesto: Dr. Julian McCreary, Director, Nova UniversityOceanographic Center, 8000 North Ocean Drive,Dania, FL 33004. An Equal Opportunity/Affirmative Ac-tion Employer.

PEDIATRIC CARDIOLOGISTSThe Department of Pediatrics at the University of

Michigan is seeking two Board-eligible/certified pediatriccardiologists for full-time, academic tenure-track posi-tions. Send curriculum vitae to: A. Rosenthal, M.D.,Director, Pediatric Cardiology, C.S. Mott Children'sHospital, University of M Medical Center,Ann Arbor, MI 49109-0204. The University ofMichi-gan is an Equal Opportunity/Affirmative Action Employer.

Ph.D. IN IMMUNOLOGY/VIROLOGY/MOL-ECULAR BIOLOGY needed by young company inBoston area to work on development of novel productsfor HIV testing, antibody-based research/diagnostictests, and nucleic acid hybridization. Focus will be onnew laboratory instruments. Candidate should haveexperience with protein/DNA electrophoresis, westernand southern blottin, and other molecular biologytechniques. Please send curriculum vitae to: Carol Wat-kins, Immunetics, Inc., 380 Groen Street, Cam-bridge, MA 02139.

POSTDOCTORAL FELLOW IN NEUROSCI-ENCE position available immediately to join a multidis-ciplinary neuropharmacology group studying the regula-tion of central and penpheral neuropeptide processing andmetabolism by drugs and disease. Opportunities to learnsolid-phase peptide synthesis and purfication, cell culture,RIA/HPLC, peptide mapping by HPLC and brain micro-slice techniques. Salary is negotiable. Closing date 30December 1989. Send curriculum vitae and names of threereferences to: Dr. Thomas P. Davis, Department ofPharmacology, University of Arizona, College ofMedicine, Tucson, AZ 85724. An Equal Opportunity/Affinnative Action Title IX Section 504 Employer.

POSITIONS OPEN

POPULATION/QUANTITATIVE GENETI-CIST with focus in fisheries science. Assistant professorin marine science, tenure-track. Expertise in contempo-rary methods of genetic analysis of natural populations,cvolutionary biology and stats essential. Successful appli-cant to develop a vigorous, independent research pro-gram using marinc organisms, collaborate in fisheriesprojects, participate in graduate teaching and researchprograms, and supervise Ph.D. and M.A. students. Ph.D.required. Postdoctoral or other appropriate researchpreferred. Scnd three references, curriculum vitae, andstatement of research interests by 15 April 1989 to: Dr.Roger Mann, Chair, Populations Genetics SearchCommittee, School of Marine Sacince, College ofWViliam and Mary, Gloucester Point, VA 23062. Theposition to be filled by 1 July 1989. The College of Williamand Mary is an Equal Opportunity/Affirmative Action Employ-er. Women and minorities are encouraged to apply.

Applications are invited for POSTDOCTORAL AS-SOCIATE positions in the laboratory of Dr. StephenReeders, Assistant Investigator, Howard Hughes Medi-cal Institute at Yale University. Molecular and cell bio-logical approaches will be applied to renal organogenesis,and the growth and differentiation of renal tubularelements. Another main interest of the laboratory is thestudy of inherited disorders ofrenal development. Appli-cants should have a strong background in molecularbiology, cell biology, development biology, or genetics.Appointments are for 2 years with an additional yearpossible. The salary range is $20,000 to $25,000 peryear, based on qualifications and experience, and anexcellent benefits package is offered. Send curriculumvitae:

Stephen ReedersAssistant Investigator

Howard Hughes Medical InstituteLCI 208, 333 Cedar Street

Yale University School of MedicineNew Haven, CT 06510

Telephone: 203-785-6737

POSTDOCTORAL ASSOCIATE POSITION INVISUAL NEUROPHYSIOLOGY available for re-search on extrastriate and inferior temporal cortex. Cur-rent research includes single neuron recording and be-havioral, ablation and anatomical experiments. Experi-ence in single neuron recording required. Behavioral,anatomical, and/or "C" programming experience desir-able. Send curriculum vitae, reprints, and names of threereferences to: C. G. Gross, Department ofPsychology,Prnceton Univcrsity, Pnnceton, NJ 08544. EqualOpportunity/Affirmative Action Employer.

POSTDOCTORAL FELLOW ORRESEARCH ASSOCIATE

Two positions available immediately. Type of ositiondependent on qualifications of the applicant. Ongoingprojects include:Chromosome 3 deletion in small cell lung cancerRetinoblastoma gene aberration in small cell lung

cancerIdentification of tumor suppressor genesRole of receptor kinases in cell differentiationPlease send in curriculum vitae, a summary of research

interests and names of three references by 1 June 1989to:Susan L. Naylor, Ph.D., or Alan Y. Sakaguehi, Ph.D.

Department of Cellular and Structaral BiologyUniversity of Texas Health Science Center

7703 Floyd Curl DriveSan Antonio, TX 78284

Telephone: 512-567-3842 or 512-567-3857An Equal Opportunity/Affirmative Action Employer.

POSTDOCTORAL FELLOWSHIP available July1989 for studies of post-receptor pathways of growthfactor action in hunan fibroblasts. Experience in analysisofgrowth factor response pathways or in basic molecularbiology techniques useful. Supported by a NIH traininggrant-U.S. citizenship required. May participate inendocrinology fellowship if qualified. Send curriculumvitae and names/telephone numbers of three referencesto: Dr. R. W. Recs-Jones, Department of Medicne,Columbia University, 630 West 168th Street, NewYork, NY 10032. Columbia University takes AfirmativeAction to ensure Equal Opportunity.

SCIENCE, VOL. 24315o8

POSITIONS OPEN

POSTDOCTORAL FELLOW AND/ORRESEARCH ASSOCIATE

RETROVIRUS RESEARCH LABORATORYCOLORADO STATE UNIVERSITY

A person(s) with experience in research techniques invirology, protein biochemistry, immunology, and/or cel-lular biology to participate in investigations of the mech-anisms ot retrovirus infection and disease in modelsystems is sought. Background in virologic and immuno-logic assays, nucleic acid, protein detection and purifica-tion methods are most relevant. Capacity for indepcn-dent work and ability to interact productively withcolleagues are important. Minimum requirements: M.S.or Ph.D. in biologic science, relevant experience. Salarycommnensurate with credentials.

Deadline: 1 June 1989Please send resume to: Dr. Edward A. Hoover,

Professor, Department of Pathology, Colorado StateUniversity, Fort Collins, CO 80523.

Colorado State University is an Equal Opportunity/Afirma-tive Action Employer and complies with all Federal andColorado State laws, regulations, and executive orders regardingAfirmative Acion requirements.

POSTDOCTORAL FELLOWSHIP/RESEARCHASSOCIATE available immediately to study cellularand molecular biology of regulation of microfilamentscytoskeletal organization and motility in neutrophils andmyeloid cells. Background in cell biology, biochemistry,and/or molecular biology preferred. Appointent mlaboratory will be in Department of Celf Biology andAnatomy at the University of Alabama at Birmingham.Send curriculum vitae, names and addresses of threereferences to: Dr. Thomas H. Howard, University ofAlabama at Birmingham, Pediatric Hematology On-cology, The Children's Hospital of Alabama, 16007th Avenue South, Birmingam, AL 35233. TheUniversity ofAlabama at Birmingham is an Equal Opportuni-ty/Affirmative Action Employer.

POSTDOCTORAL FELLOWSHIPSDEPARTMENT OF CELLULAR AND

DEVELOPMENTAL BIOLOGYORGANISMIC AND

EVOLUTIONARY BIOLOGYHARVARD UNIVERSITY

A limited number of postdoctoral research positionsbecome available from time to time. Some appointmentsare funded through research grants awarded to facultymembers and are ordinarily for 1 year, sometimes renew-able, other appointments are possible through postdoc-toral fellowships. For a list offaculty members who havepostdoctoral positions available, write to the respectivedepartment office: Harvard University, 16 DivinityAvenue, Cambridge, MA 02138. (Do not send applica-tions.) Harvard University is an Equal Opportunity A rma-

tive Action Employer.

POSTDOCTORAL OPPORTUNITIESHoward Hughes Medical Institute, a leading medical

research organization, has postdoctoral positions avail-able to study the structure-function relationships ofblood-clotting proteins or cellular regulation of receptorexpression.You will work in a new facility with monoclonal, tissue

culture and structural biology core facilities. Experiencein molecular or cell biology, or protein or physicalchemistry is preferred.To apply, send curriculum vitae and two recommenda-

tions to: Charles T. Esmon, Ph.D., Howard HughesMedical Institute, do Oklahoma Medical ResearchFoundation, 825 NE 13, Oklahoma City, OK 73104.Equal Opportunity Employer.

POSTDOCTORAL POSITION

Available for a microbiologist with biochemical back-ground. Candidates should have experience in handlinganaerobic microorganisms, in the characterization oflipopolysacharides and proteins, and in the use of iso-topes. Send resumr and two letters of reference to:Professor Wllliam W. Yotis, Department ofMicrobi-ology, Loyola University Stritch School of Medicine,MaIyIo IL 60153. Telephone: 312-531-3397.Loyola University ofChicago is an Equal Opportunity/Affirm-ative Action Employer.

17 MARCH I989

Cal Bio, a leading biotechnology company engaged in developing humantherapeutics and protein drug delivery systems, has positions available in thefollowing research areas:

Scientist/Sr. Scientist- Biological TestingUse a broad physiology background and 3-5 years' relevant experience to testin vivo models for tissue repair, drug delivery systems, cardiopulmonary func-tions, or metabolic systems. Position includes supervision of 2-3 ResearchAssociates. A PhD is required and industry experience preferred. Code LM-CK.

Protein Biochemist- NeurobiologyJoin a team of molelcular and cell biologists developing novel therapeutics forthe treatment of neuropathies. Position requires experience with proteinanalysis and purification techniques including all types of chromatography aswell as biochemical, biological, and immuno assays. Experience with polypep-tide hormones and their receptors is helpful. Qualified candidate has a PhD ina scientific discipline with or without postdoctoral experience. Previousresearch experience in neurobiology not required. Code LM-FF.

ScientistApply your expertise to cDNA library construction, oligonucleotide design andscreening, and expressions strategies for cloned cDNA's. Candidate shouldpossess a PhD and 2-4 years' related experience. Code LM-LJ.

Protein BiochemistConduct research on human therapeutics for Diabetes/Obesity, one of CalBio's four focus areas. This position requires protein purification expertiseinvolving analytical HPLC method development. Individual should possess aPhD with 1-2 years' experience, or a BS/MS with 3-5 years' experience.Code LM-RA.

PostdoctoralTwo opportunities exist: the first involves research into the molecular biologyand biochemistry of growth factors and their role in wound healing, the secondrequires analysis of the receptors for atrial natriuretic peptides and their syn-thetic analogs. Code LM-JF.

Research AssociateslSr. Research AssociatesSeveral positions exist for researchers in our four focus areas: diabetes/obesity, tissue repair, cardiopulmonary, and drug delivery research. A BS/MSplus 1-3 years' lab experience in one of the following areas is required: ProteinChemistry, Molecular Biology, Biochemistry and Cell Biology. Code LM-RR.Cal Bio offers a stimulating work environment and a competitive compensa-tion and benefits program. For immediate consideration, please forwardyour curriculum vitae, hdilCatb job ode, to: Liza Mingione, CaliforniaBiotechnology Inc., Human Resources, 2450 Bayshore Parkway, MountainView, CA 94043. We are an equal opportunity/ affirmative action employer.

CAL---BIO

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The Department of Experimental Pathology, Smith Kline & FrenchLaboratories, has a position available for a veterinary clinical pathologist.Smith Kline & French, a leader in pharmaceutical research, is located insuburban Philadelphia, near Valley Forge.The successful applicant must have demonstrated expertise in the field ofclinical pathology and a proven record of accomplishment either throughpublication or relevant postdoctoral experience leading to an M.S. or Ph.D.degree. Board certification is preferred but is not essential. Expertise incomparative hematopathology is highly desirable. The position hasmanagerial responsibility for a group of ten technologists in hematologyand clinical chemistry. The incumbent will direct studies intended to definethe toxicologic profile of pharmacological agents and will participate as amember of a team engaged in drug development. The successful candidatewill be expected to design and conduct studies to resolve issuessurrounding drug-induced hematoxicities. The position offers substantialopportunity for collaboration with scientists involved in the discovery anddevelopment of novel thrombolytic agents and hematopoietic growthfactors. Opportunities for professional growth are also offered throughpublication and presentation at scientific meetings.Smith Kline & French Laboratories offers excellent compensation and workrelated benefits, an attractive rebcation policy and a collegial workenvironment that offers considemable opportunity for personal andprofessional growth. For confidential consideration, please forward yourcurriculum vitae to: Elizabeth McKendry, Associate EmploymentAdministrator, L0045, Smith Kline & French Laboratories, Research andDevelopment, P.O. Box 1539, King of Prussia, PA 19406-0939. We are anEqual Opportunity Employer, M/F/H/V.

ASSISTANT DIRECTORThe Princeton Plasma Physics Laboratory, one of the world's leading

laboratories engaged in the development of magnetic fusion as an inex-haustible energy source, seeks an Assistant Director who will serve asExecutive Officer for the Laboratory's internal and external Advisory Coun-cils and be responsible for the Laboratory's interaction with federal andstate government and long-range planning activities.

The essential qualifications for this position are experience with FFR&Dlaboratory relationships with federal and state legislative bodies andexecutive agencies, an advanced degree and experience in physics or aclosely allied engineering discipline, and experience as a technical man-ager. Familiarity with the interactions of the academic and industrial sectorswith FFR&D institutions is highly desirable.

The Laboratory offers stimulating and challenging work, a salary fullycommensurate with experience and a comprehensive benefit package.

Please forward a detailed resume, names of references, and salaryrequirements by 31 March 1989 to:

Dr. Harold P Furth, DirectorPrinceton Plasma Physics Laboratory

Post Office Box 451Princeton, New Jersey 08543

An Equal Opportunity/Affirmative Action Employer

_Plasma Physics

~Princeton University

ISkin Biology-AssociatesThe Hairgrowth Research Group of The Upjohn Company is seekinghighly motivated applicants for research associate positions to participatein studies of mechanisms that control growth and differentiation in hairand/or skin. These positions are available to MS or BS level professionalshaving several years of related experience. Must have demonstrated abili-ty to work independently and in collaboration with members of a multi-disciplinary research team.

Morphologist-Conduct in vivo research with animals and primates tocharacterize structural derangement in the skin and hair follicles of animalmodels. Develop assays to quantitatively evaluate stimulation or inhibi-tion of hair growth. Must be skilled in administration of drugs to animals,collection and preparation of skin and hair for examination at the lightand electron microscopic levels. Experience in modern morphologicaltechniques such as computerized image analysis, immunohistochemistryand autoradiography is desirable.

Cell Biologist-identify and characterize molecules that modulate in-tercellular communication in hair follicles and/or skin. Studies requireexperience in generating monoclonal antibodies, developing im-munoassays, or preparing skin specimens for histological examination.Additional knowledge of biochemical techniques (e.g., purification, elec-trophoretic analyses) is desirable.

We are located in southwestern Michigan, midway between Chicago andDetroit. Upjohn offers personal and career advancement opportunities,a highly competitive salary, comprehensive benefits and relocationassistance. For confidential consideration, call from outside of Michigantoll free 1/800/253/8600, ext. 3-6767, (inside Michigan call collect616/323-6767) to request an employment application be sent. Please referto advertisement number 23690-HA when calling. An Equal Opportuni-ty Employer M/F.

Our Commitment to ScientificExcellence Continues . ..

DEPARTMENT OF HEALTH AND HUMAN SERVICESPublic Health Service

Alcohol, Drug Abuse, and Mental Health AdministrationNational Instvtte of Mental Health

Extramural Staff Fellowships in NeuroscienceThe Neurosciences Research Branch, of the Division of Basic Sciences,

an extramural grant program of the NIMH, has immediate staffingopportunities in the areas of Melecular Neurobielogy/lmmunelogy and Thuret-ical NNresclenec The staff fellows will assist existing program staff in thedevelopment of two new grant support programs designed to encouragethe application of experimental strategies utilizing either advancedmolecular biologicaVimmunological techniques or mathematical andcomputational techniques toward understanding basic brain function andmental health research problems. Responsibilities include: conductinganalyzing and evaluating research and research trends; consulting withgrant applicants; conducting workshops; interacting with researchers invarious research settings.Applicants must have a PhD. degree and up to three years of post-

doctoral research experience in a neuroscience-related discipline, withextensive training in either molecular biological theory and technology ormathematical/computationaVtheoretical neuroscience. Initial appointmentswill be made for up to two years with yearly extensions to a maximum ofseven years. Starting salaries range from $28,850 to $53,460. Relocationexpenses may be paid. U.S. citizenship or permanent residency status isrequired. Fellows are eligible for full Government benefits and leave. Dutystation is Rockville, MD. Applications will be accepted until positionsare filled.Interested persons should send a letter of interest and a curriculum vita

in confidence to: Ronald Schoenfeld, PhD., Acting Chief, NeurosciencesResearch Branch, Division of Basic Sciences, National Institute of MentalHealth, Room 11-105, 5600 Fishers Lane, Rockville, MD 20857. (301)443-1504.

ADAMHA is an Equal Opportunity Employer

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The US. Environmental Protection Agency direct and manage the program. This includes(EPA) is seeking candidates for the position of developing the program to meet the evolvingDirector, Human Studies Division, Health Effects needs of EPA, presenting the program, developingResearch Laboratory (HERL). This position is and managing budgets, supervising the staff,located in Research Triangle Park, N.C. and is a directing the progress of the program and ensuringpermanent full-time position with a salary range the scientific quality and productivity of the pro,gram.Hur, an '>,I,5 f i es of $57,158 to $74,303 per annum commensurate The preferred candidate for this position would

Igf/gIfgf^@gX Sf@ t@ with qualifications. Additional salary incentives possess the following qualifications:/ff X v ,xx>M"> g2j7,.t ' are available should a physician be selected for

this position. 1. Advanced degree in a biological or medicalHealth Effects HERL has a staff of about 300, over 100 of whom discipline or epidemiology with at least six yearsResearch Laboratory hold doctoral level degrees. The Laboratory has a of professional experience in any of these areas.

divese rogrmwich ncldes n vtro,anial, Appllcable graduate coursework may be substitutedResearch Triangle Park, NC o afor a portion of the preferred experience.human, clinical, and epidemiological research

designed to address issues related to the health 2. Experience as a supervisor of a scientific!effects of air and water chemical and biological professional staff.pollutants. 3. Recognized scientific expertise as evidenced by

AN% The Human Stiiaies Division (HSD) is a multi- multiple publications in peer-reviewed literaturedisciplinary program organized into two branches: and invitations to participate in national and inter-Clinical Research and Epidemiology with a com- national meetings/panels.

AP bined EPA staff of 35, with approximately 75 on-site 4 Proven ability to provide leadership in directingcontractor personnel. The Division is a focal the development and progress of a creative and

U.S. point for planning, conducting, coordinating, effective multidisciplinary human researchsupporting and evaluating a program of clinical program.Envirorinmental and epidemiological investigations to improve the 5 US citizenship is required.

- understanding of human health risks associatedProtection with environmental pollution. The program includes Forward curriculum vitae and names of threelx)th intramural investigations andextamuralarrange references prior to May 1 (previously April 17)Rgency osaneamrlx_Q-ments with universities, industry, private research 1989 to: Dr. Lawrence W Reiter, clo Terni Burrll,institutions and other government agencies. The HRMD (MD-29), U.S. Environmental Protection

An Equal Opportunity Employer primary responsibilities of the Director are to Agency, Research Triangle Park, NC 27711.

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GLAXO INSTITUTE FOR MOLECULAR BIOLOGY S.A.

The Geneva biotechnology research unit of the largest U.K. pharmaceutical group has a vacancy for:

AN ANIMAL-CELL FERMENTATION SCIENTISTWe are expanding our activities in the area of animal cell cultivation and are seeking a scientist to lead a cellculture laboratory within our Fermentation group. The successful candidate should have a strong scientificbackground in the general area of animal cell biology or fermentation and post-doctoral experience in theculture of animal cells in fermenters. In addition the applicant should be able to contribute actively to thedevelopment of research projects in one or more of the areas of current interest to the Institute. Currentprojects include antiviral and antifungal therapeutics, inflammatory diseases and the regulation of cellproliferation and development.

The Institute has a staff of over one hundred, grouped in small teams of specialists from several domains ofmodern biology. We are part of the Glaxo Group - one of the world's leading pharmaceutical companies -which has an outstanding reputation for the quality of its research and products.

We offer an excellent salary and benefits package, with opportunities for career development in one of themost attractive parts of Europe.

If you are interested in this position, please send your curriculum vitae with a list of publications and thenames of three references to: Rita Gloor, Personnel Manager, GLAXO IMB SA, 46, route des Acacias,1211 Geneva 24, Switzerland.

POSITIONS OPEN

POSTDOCTORAL PHARMACOLOGISTXOMA Corporation is a world leader in the develop-

ment and clinical testing of therapeutic pharmaceuticalsfor human use. This highly visible position is responsiblefor the overall scientific and administrative direction ofthe Pharmacology group. Design, carry out an interpret-ed pharmacological pharmacokinetic and efficacy studieswith XOMA products currently in development. Willalso develop animal model systems for evaluation ofseptic shoc , anti-cancer and immune-related diseasespublication/presentation to the FDA. One to two juniorscientists report to this position. Ph.D. in Pharmacologyor related discipline, 0 to 5 years of postdoctoral experi-ence, including extensive use of laboratory rodents forpharmacokinetic, tissue distribution studies. Experiencewith immunological model systems using normal andnude mice, biostatistics and computer usage desirable;supervision experience desired. XOMA offers competi-tive salary and comprehensive benefits in an outstandingwork environment. For consideration, please forwardyour curriculum vitae and salary history to: Director ofHuman Resources, XOMA Corporadon, 2910 Sev-enth Street, Berkeley, CA 94710. Equal OpportunityEmployer.

POSTDOCTORAL POSITION available 1 JulY1989 or thereafter to study the role of autocrine growthfactors and mechanisms ofoncogene action in the regula-tion of epithelial growth and differentiation in cultureand in vivo. This project will employ techniques ofhuman keratinocyte, mesotheial, and fibroblast cell cul-ture and defective retroviral transduction, and may alsoinvolve in vitro mutagenesis and gene cloning. Appli-cants should have a recent Ph.D. in molecular genetics,biochemistry, or epithelial cell biology. Position carriesjoint appointment in the Department of Cellular andMolecular Physiology at Harvard Medical School. Sendcurriculum vitae, summary of research and course experi-ence, thesis abstract, and the names of three referencesto: Dr. James G. Rheinwald, Dana-Farber CancerInstitute, 44 Binney Street, Boston, MA 02115. AnEqual Opportunity Employer.

POSTDOCTORAL POSITION for a Ph.D. tostudy electrophysiology of transmitter release at theneuromuscular junction. Available up to 3 years startingat $21,370 per annum. Send curriclum vitae and namesof three references to: M. D. Miyamoto, PharmacologyDepartment, Box 19810A, East Tennessee State Uni-versity, Johnson City, TN 37614. ETSU is an EqualOpportunity/Affirmative Action Employer and employs onlyU.S. citizens and aliens authorized to work in the UnitedStates. Position contingent upon grant fimding.

POSTDOCTORAL POSITION available immedi-ately to study regeneration in the central and peripheralnervous system. Both in vivo and in vitro models will beused. Experience with animal models, cell biology, im-munochemistry and tissue culture desirable. Send curric-ulum vitae, names, addresses, and telephone numbers ofthree references, and a brief description of researchexperience to: R. Pitas, Gladstone Foundation Labo-ratories for Cardiovascular Disease, University ofCalifornia, P.O. Box 40608, San Francisco, CA94140-0608.

POSTDOCTORAL POSIIION available immedi-ately to study the enzymatic mechanisms of DNA recom-binases and DNA helicases. The research will include theuse of protein engineering to construct mutant enzymeshaving altered catalytic properties. Experience in mecha-nistic enzymology, nucleic acid biochemistry, or proteinchemistry is required. Send curriculum vitae and namesof references to: Dr. F. R. Bryant, Department ofBiochemistry, Johns Hopkins University, 615 NorthWolfe Street, Baltimore, MD 21205.

POSTDOCTORAL POSITION available in CellBiology laboratory interested in hematopoietic cell dif-ferentiation. Opportunity to study the role of tyrosinekinase oncogenes in megakaryocyte differentiation or therole of nuc ear oncogenes in normal human monocytedifferentiation. Experience with techniques in contempo-rary cell and molecular biology required. Send curricu-lum vitae with three references to: R A. Mufson, Ph.D.,American Red Cross, Holland Laboratory, 15601Crabbs Branch Way, Rockville, MD 20855. EqualOpportunity Employer/M/F/V/H.

POSITIONS OPEN

POSTDOCTORAL POSMON available immedi-ately to study translational regulation of growth factors.Recent Ph.D. with experience in recombinant DNAtechnology is preferred. Salary commensurate with quali-fications. Send curriculum vitae and three letters ofreference to:

Kailash C. Gupta, Ph.D.Department of Immunology/Microbiology

Rush Medical College1653 West Congress Parkway

Chicago, IL 60612Rush is an Equal Opportunity/Affinnative Action Employer.

POSTDOCTORAL POSMON in computer-aideddrug design, available 1 June 1989. The project involvesdeveloping novel methods of deducing the receptor sitegeometry and energetics from experimental binding data.The ability to write computer programs is essential, andfamiliarity with QSAR is helpful. Send curriculum vitaeand names of three references to: Dr. G. M. Crippen,Collegc of Pharmacy, University of Michigan, AnnArbor, MI 48109. Equal Opportunity/Affirmative ActionEmployer.

POSTDOCTORAL POSITION available immedi-ately for pharmacologist/biochemist to study signal trans-duction in tumor promotion and progression. interestedcandidates should send their curriculum vitae and namesof three references to: Dr. Barbour S. Warren, Univer-sity ofTcxas M. D. Anderson Cancer Center, SciencePark, P.O. Box 389, Smithville, TX 78957. An EqualOpportunity/Affirmative Acion Employer. UTMD AndersonCancer Center is a smoke-free workplace.

POSTDOCTORAL POSITION available immedi-ately for multidisciplinary study of angiogenesis in am-phibian model systems. Background in cell culture andimmunocytochemistry desirable. Send curriculum vitaeand names of three references to: Dr. Carl M. Ro-vainen, Department of Cell Biology and Physiology,Box 8101, Washington University School of Medi-cine, 660 South Euclid, St. Louis, MO 63110. Tele-phone: 314-362-2299. Affirmative Acion/Equal Opportu-nity Employer.

POSTDOCTORAL POSMIIONLaboratories studying phospholipid-derived mediators

and ionic fluxes in pancreatic islets have positions forpostdoctoral fellows with experience in biochemistry,chemistry, pharmacology, or a related discipline. Train-ing provided in GC, HPLC, GC/MS, phosphoproteinanalysis, immunoassays, small animal surgery. In depart-ment with multidisciplinary collaborative interactions instudy of insulin secretion, insulin action, diabetic compli-cations, and islet transplantation. Positions supported bytraining grant requiring U.S. citizenship or permanentresident status. Salary on NIH scale. Contact: Dr. JohnTurk or Dr. Michael McDaniel, Box 8118, Washing-ton University School ofMedicine, 660 South EucldAvenue, St. Louis, MO 63110. Equal Opportunity/Af-firmative Action Employer.

POSTDOCTORAL POSITION-ECOSYSTEM MODELING

Applicants should have a strong background in quanti-tative studies, experience in simulation modeling, and aninterest in holistic studies of ecosystems. Doctoral train-ing may be in any area of biological or environmentalscience. Appointment will begin in August, 1989 orlater. This is a full-time, 12-month appintent with asalary of $20,000 and a full range of benefits. A1-yearrenewal is possible. Submit resume three letters ofrecommendation and transcripts of all academic work to:Orie L. Loucks, Department of Zoology, MiamiUniversity, Oxford, OH 45056. Equal Opportunity/Affirmative Action Employer.

POSTDOCTORAL POSMIION IN MOLECU-LAR ENDOCRINOLOGY. Position available July1989 for studies ofhormonal regulation ofgonadotropingenes. Research involves promoter mutagenesis, genetransfer experiments and interactions of hormone re-sponse elements with transcription factors. Backgroundin molecular biology preferred. Send curriculum vitae,description of research background, and three letters ofreference to: Dr. Larry Jameson, Chief, Thyroid Unit,Massachusetts General Hospital, Boston,MA 02114.An Affiirmative Action/Equal Opportunity Employer.

POSITIONS OPEN

POSTDOCTORAL POSMONIN MARINE AND ESTUARINE SCIENCESThe University ofMaryland Center for Environmental

and Estuarine Studies (UMCEES), Horn Point Environ-mental Laboratories, located on Chesapeake Bay, isseeking to fill a postdoctoral position in any one of abroad spectrum of disciplines. These include: physicaloceanography; phytoplankton, zooplankton and bacter-ioplankton dynamics; ecology of vascular plant commu-nities; nutrient cycling processes; benthic ecology andgeochemistry; iverebrate behavior, development andphysiology; and seafood technology. The position isavailable from 1 November 1989, for 1 year withpossible renewal for a maximum of2 years. Send r6sumrand three letters of reference by 30 April 1989 to: Dr.W. Michael Kemp, Chairman, Postdoctoral SearchCommittee, Horn Point Environmental Labora-tories, P.O. Box 775, Cambridge, MD 21613. TheUniversity ofMaryland is an Affirmative Action/Equal Oppor-tunity Employer.

POSTDOCTORAL POSIIION INPLANT MOLECULAR BIOLOGY

To work on one of the following: (i) Evolution ofgene families and mechanisms of DNA duplication andmovement within and among the plant genomes, (ii)Molecular evolution of flower-pollinator interaction.Other topics in molecular evolution might also be suit-able. Position available 1 July 1989. Write to: EranPichersky, Biology Department, University of Michi-gan, Ann Arbor, MI 48109; Telephone: 313-936-N522. Please include curriculum vitae, and have threeletters of recommendation sent directly.

The University ofMichigan is a non-discriminatory/Afirma-tive Action Employer.

POSTDOCTORAL POSMIIONS available imme-diately to study cytoskeletal-membrane interactions inneural cells. Projects deal with the interaction of brainspectrin with other proteins (synapsin I, amelin, ankyrin,actin, calmodulin and adducin). Candidates should havebackground in biochemistry/molecular biology or mono-clonal antibody technology. Send curriculum vitae andthe names of three references to:

Dr. Steven R. Goodman, ChairmanDepartment of Structural and Cellular Biology

University of South AlabamaCollegc of Medicine, Room 2042 MSB

Mobile, AL 36688The University of South Alabama is an Equal Opportuni-

ty/Affirmative Action Employer.

Several POSTDOCTORAL POSMIIONS in iso-tope biochemistry available 1 June 1989 or later. Studiesoo isotope fractionation in enzyme-catalyzed reactionsand in plants. Send curriculum vitae and letters ofrecommendation by 1 May 1989 (or until suitablecandidates apply) to: Dr. Marion H. O'Leary, Head,Departnent of Biochemistry, University of Nebras-ka-Lincoln, Lincoln, NE 68583-0718.

U.S. DEPARTMENT OF AGRICULTUREAGRICULTURAL RESEARCH SERVICEPOSTDOCTORAL RESEARCH ASSOCIATE

immediately available to characterize and clonc avianlymphokines. Candidate must have background in bio-chemistry, immnunology or molecular biology. Experi-ence in lymphokine research is desired. Ph.D. required.Salary is commensurate with experience ($28,852 to$34,580). Send applications (SF-171) to: Dr. H. Lille-hoj, USDA, ARS, Protozoan Diseases Laboratory,Building 1040, BARC-East, Beltsville, MD 20705 orcall: 301-344-1771. Applications should be marked9E002 and received by 1 September 1989. An EqualOpportunity Employer.

POSTDOCTORAL RESEARCH ASSOCIATEPosition available to study the structure and functional

domains of the two surface glycoproteins of the Para-myxovirus, Newcastle disease virus, and the mechanismof viral neutralization by monoclonal antibodies. Sendcurriculum vitae and the names of three references to:Dr. Ronald Iorio, Departnent of Molecular Geneticsand Microbiology, University ofMassachusettsMedi-cal School, 55 Lake Avenue North, Worcester, MA01655. Affinnative Action/Equal Opportunity Employer.

SCIENCE, VOL. 243I512

Opportunities inInflammation, Pulmonary and

Immunology ResearchPfizer Central Research has several immediate open-ings for research assistants within its expanding Depart-ment of Immunology and Infectious Diseases. You willjoin multidisciplinary projectteams engaged in researchtowards discovery of novel therapies for a variety ofinflammatory, pulmonary and autoimmune diseases.

Histologist/Electron MicroscopistYou will conduct in vitro and in vivo experimentsutilizing histological and ultrastructural techniques.Ideally, you should have an MS or BS degree in abiological science with experience operating andmaintaining a range of laboratory instrumentsincluding SEM, TEM and ultramicrotomes. Laboratoryskills in one or more of the following areas are alsodesirable: immunohistochemistry, immuno-electronmicroscopy, image analysis and cell labeling.BiochemistWill conduct experiments related to the biochemistryand physiology of human and mammalian white bloodcells. You should possess an MS or BS degree inbiochemistry, immunology or biology. Laboratoryexperience in the following areas is desirable: isolationof cells from blood and exudates; measurement ofmembrane receptors using radioligand binding assays;quantitation, isolation and purification of arachidonicacid pathway metabolites and intracellular proteins.Experience with HPLC and electrophoretic tech-niques would be particularly useful.

ImmunologistRequires an MS in immunology or biochemistry or aBS with extensive laboratory experience. Experiencein one or more of the following areas is necessary: cellmediated immunity; regulation of lymphokine produc-tion/activity; production, characterization and purifica-tion of monoclonal and polyclonal antibodies; in vivomodels of arthritis and autoimmunity.Pulmonary BiologistThe successful candidate will have a BS or MS degreein physiology or biology and experience with pulmonarypharmacology. Ideally, this experience should

include the development of aerosol drug deliverysystems and the measurement of the mechanics ofrespiration.Cellular PhysiologistA BS or MS degree plus several years of relevantresearch experience in cellular physiology or immunol-ogy and cell surface phenotyping are required. Exper-tise in characterizing ion channels by whole cell patch-clamp recording techniques and/or fluorescenceimaging would be especially valuable. Other usefulexperience would include a working knowledge ofbasic fluorescence and computers.Analytical BiochemistYou will quantitatively analyze a variety of mediatorsand investigative compounds in the context of in vivomodels. Requires at least a BS degree in a relevantarea of science and experience with HPLC techniques.Experience with other analy'tical methods such asRIA and ELISA, as well as a familiarity with computeranalysis of data, is also desirable.Pfizer offers a stimulating scientific research environ-ment with the opportunity to interact with scientistsfrom several disciplines. In addition, Pfizer has acompetitive compensation/benefit package alongwith relocation assistance to this southeastern Connec-ticut shoreline community. Please send a resumeindicating position of interest, a description of yourresearch experience, and names of three referencesto: Mrs. Lorraine C. Corr, Personnel Associate, PfizerCentral Research, Eastern Point Road, Groton, CT06340. An equal opportunity employer

I

A cytogeneticist (PhD) withcredentials in clincial cyto-genetics is required for a 700+bed teaching hospital in NewYork City. A laboratory forclinical material of600 sq. ft. isavailable and additional spacefor research will be remodeledfor a candidate with researchgrant support. The hospital isthe major affiliate of SUNY(Downstate) and an appoint-ment will be made at the assis-tant or associate professorlevel. The present clinical loadis 400 amniocentesis and 50-70leukemias/year.

Please send resume to:

H. Simpkins, M.D., Ph.D.Professor of Pathology (SUNY)Chair, Department of Pathology

The Staten Island Hospital andRichmond Memorial HospitalCommunity Health System of Staten Island

"Partners in Quality Care"475 Seaview Ave, Staten Island, NY 10305

JUNIORRESEARCHBIOLOGIST

Merck Sharp and Dohme ResearchLaboratories, a world leader in thedevelopment of ethical pharma-ceuticals for human and animalhealth, is currently offering an ex-cellent career opportunity for abiologist to join a team working onavian coccidiosis in the Depart-ment of Biochemical Parasitologyin Rahway, New Jersey.The position requires a M.S. degreeor equivalent (or B.S. plus two ormore years of research experience)in Poultry Science or related field.Experience in avian parasitology orimmunology would be useful.Salary and benefits are excellent.Our location is Rahway, NewJersey, 25 miles from New York City.Interested applicants should sub-mit a resume to Ms. DeloresBarefield, Merck Sharp and DohmeResearch Laboratories, P.O. Box2000, WBD-362, Rahway, NewJersey 07065. An equal opportunityemployer mi/f/v/h.

Enzymatics, Inc- usesstate-of-the-art applied enzymology in de-

veloping a new generation of ma-chine independent medical diagnos-tics and bzosensors. We are lookingfor motivatedproblem solvers tojoinour rapidlygrowing team.Research Scientist, Ph.D.: Will have4+ years postdoctoral experience.Strong background in organic chem-ist?y with experience in polymer orprotein chemistry required.

ResearchAssociates, MS/BS: Requires2+ yea?s ofproblem solving experi-ence in biochemistry.Enzymatics, Inc. exists in an innova-tiveand dynamicR&D environment.We offer equity participation, com-petitve salary and benefits, and un-7imited growtb potential. Send res-ume, including salary history andthree references to:

Personnel, Enzymatics, Inc355Business CenterDnrve * Horsham, PA19044 EOEM/F

- Wdl BiogyWe are currently seeking a staffscientist to join our tissuegrowth and repair group. Theideal candidate will be respon-sible for initiating and directingresearch aimed at understand-ing the roles of growth factorsand their receptors in celldifferentiation, with particularemphasis on the mechanismsof signal transduction. A PhDin cell and developmental biol-ogy, at least 2 years of relevantpostdoctoral work and previousexperience with growth factors,receptors and in vitro assays re-quired.We offer a stimulating and dy-namic work environment in ad-dition to an excellent salary andcomprehensive benefitsprogram.Interested candidates shouldforward a resume, in confidence,to: Barbara Covel, Director ofHuman Resources, GeneticsInstitute, 87 CambridgeParkDrive, Cambridge, MA 02140.

An Equal OpportunityEmployer, M/F/HN.

Genetics Institute

UNIVERSITY OF TEXASHEALTH SCIENCE CENTER

AT SAN ANTONIOFACULTY POSITION

The Program in Physical Therapy Educationannounces a 12-month, tenure track position atthe Associate/Assistant Professor rank. We areseeking an individual with expertise in cardiopul-monary physiology/rehabilitation, exercise physi-ology, neurophysiology or a closely related area.Applicants need not be physical therapists butmust have interest and background in areasrelated to rehabilitation. Opportunities to teachat the graduate and undergraduate levels as wellas perform research in areas of interest andrelated activities. Research support Includingstart-up monies Is negotiable.San Antonio offers high quality, affordable

living in a city which has numerous recreationalopportunities and major tourist attractions. Allthis with no state Income tax. Our program isvery well resourced and numerous opportuni-ties exist for collaborative research with otherdepartments within the Health Science Center.Salary and benefits package are excellent.

Applications are now being accepted and willcontinue to be accepted until the position isfilled. Start date is negotiable.

Contact:Pamela A. Stanton, EdD,

//4,^ DirectorPhysical Therapy ProgramThe University of Texas HealthScience Center at San Antonio7703 Floyd Curl DriveSan Antonio, Texas 78284

The University of Texas Health Science Centerat San Antonio is an equal opportunity!

affirmative action employer.

TERATOLOGIST/REPRODUCTIONTOXICOLOGIST

Life Science Research-Roma Toxicolo-gy Centre seeks applications for the posi-tion of Study Director from individualswith 2 to 5 years experience in productsafety assessment using the Segment I,11 and III protocols. Working knowledge ofvisceral and skeletal examination meth-ods for assessing altered fetal develop-ment is desirable. An interest in investi-gation of alternative methods for indicat-ing developmental and reproductivehazards will be useful.Ability to effectively communicate in En-glish is essential. Knowledge of Italian isdesirable, but instruction will be provided.The laboratory is located on the coast ofItaly 20km south of Rome. We offer aunique opportunity to gain internationalexperience in contract toxicology with acompetitive salary.Please send Curriculum Vitae by expressmail to:

Director of ToxicologyLife Science Research-Roma Toxicology CentreVia Tito Speri, 1400040 Pomezia (Roma)-ItaliaFax no. : 36-6-9125387Tel. no. : 39-6-9120351I

r

UNATIONAL INSTITUTESOF HEALTH

IMMUNOLOGIST/CELL BIOLOGIST

Experience in immunology,cell biology and molecular biol-ogy to study the role of humanCD5+ B lymphocytes in the nor-mal and autoimmune repertoireand to make human monoclonalantibodies. The candidateshould have at least two yearspostdoctoral experience. The ini-tial appointment will be for twoyears, with renewals on a yearlybasis. Starting salary range, de-pending on experience, is$30,000 to $50,000 per year. Theposition is available immedi-ately. Send Curriculum Vitae andnames of references to Dr. LoisSalzman, Deputy Director In-tramural Research Program,National Institute of DentalResearch, National Institutesof Health, 9000 Rockville Pike,Building 30, Room 121,Bethesda, Maryland 20892.NIH is an Equal OpportunityEmployer.

CHAIRMANMEDICAL SCIENCES DIVISION

Nominations and applications are invited for the position of Chairman of the Medical Sciences Division of Oak RidgeAssociated Universities. ORAU is a private, not-for-profit consortium of 49 colleges and universities and a managementand operating contractor of the U.S. Department of Energy. Its mission is to carry out research and development inmedical sciences, science/engineering education, productivity management and training, and energy/environmentsystems.

The chairman provides scientific and managerial leadership to strengthen, build and conduct Division programs thataddress critical medical and health issues associated with energy. The Chairman's responsibilities include providing broadscientific and managerial leadership, developing a strong staff, allocating resources, and representing the Division tofederal agencies, universities, and other organizations.The Division's interdisciplinary staff of about 125 investigates the medical benefits and costs to the human body fromnatural and synthetic substances, primarily those from energy and energy-related technologies. It carries out basicpreclinical research; develops beneficial applications to human health from science and technology; develops techniquesto avoid moderate, or reverse negative health impacts; analyzes the health risks and outcomes from applications oftechnologies; and provides information systems and management expertise to deal with health-related impacts.Qualifications for the position include a doctorate in medicine and/or health science; an established record of excellence inresearch and/or research leadership; the ability to build a strong organization and staff, and to work effectively within andoutside ORAU. Excellent writing and presentation skills and leadership qualities reflected in vision, innovation, andorganization are required.Applications should include a letter of interest, a vita, a list of publications, and the names and addresses of at least threereferences. The Search Committee will begin its review in April 1989 and continue until the position is filled. The appointeewill assume the full responsibilities of Chairman in early 1990. A transition period preceding the retirement of theincumbent is planned.Applications, nominations, and inquiries should be sent to: Jon M. Veigel, President, Oak Ridge AssociatedUniversities, P.O. Box 117, Oak Ridge, TN 37831-0117. An Equal Opportunity Employer.

OAKTRIDGEASSOCIATED UNIVERSITIES

Group LeaderProtein Chemistry-Enzymology

The Henkel Group, a leader in appliedchemistry, with worldwide annual salesof $5 billion, seeks a senior scientistto join existing biotechnology efforts.A position of responsibility is availableat Henkel's West Coast researchfacility in Northern California.The successful candidate will reportto the Director and assist in programdevelopment. Applicants should havea PhD in Chemistry, Biochemistry,Microbiology or a closely related fieldand three or more years' experienceafter postdoctorate in industry or aca-demia. Scientific leadership in proteinchemistry and enzymology is essential,as is experience directing PhD scien-tists. Incumbent will plan, direct andconduct research in the analysis andapplication of industrial enzymes forHenkel products and processes.For confidential consideration, sendcomplete curriculum vitae with refer-ences and salary requirements to: Per-sonnel Director, HENKEL RESEARCHCORPORATION, 2330 CircadianWay, Santa Rosa, CA 95407. We arean equal opportunity employer.

en

FE

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POSITIONS OPEN

POSTDOCTORAL RESEARCH ASSOCIATEto develop nonconventional systems for crop improve-ment. Two-year appointment at $22,000 per year, avail-able immediately. Funded by the Christine Lee ShepardMemorial Fund, established to promote innovative re-search for plant improvement. Required: Ph.D.; trainingin recombinant DNA and/or plant tissue culture. Sendcurriculum vitae, including coursework transcripts, astatement of research interests, and have three letters ofreference sent by 15 April 1989, to: Dr. Frank VVhite,Department of Plant Pathology, Throckmorton Hall,Kansas Statc University, Manhattan, KS 66506. Tcle-phone: 913-532-6176. Equal Opportunity/Affirmative Ac-tion Employer.

POSTDOCTORAL RESEARCHASSOCIATE POSITION

A postdoctoral position is open to study nuclearscaffold enzymes in relation to RNA Transport. Appli-cants should have a strong background (with publica-tions) in either monoclonal antibody production andhandling or in cloning/sequencing procedures. Salarycommensurate with experience. Excellent benefit pack-age. Equal Employment Opportunity. For further informa-tion, contact: Dr. Gary Clawson, 202-994-5057.

THE ROCKEFELLER UNIVERSITYPOSTDOCTORAL RESEARCH FELLOWSHIPOne position is available for a postdoctoral researcher

trained in molecular and/or biochemical techniques tostudy various aspects of growth regulation and responseof epithelial cells to autocrine hormones and cytokines.Applicants with backgrounds in growth regulation,growth factors/oncogenes, or immunology are preferred.Salary depends upon experience. Please send curriculumvitae and names of three references to: Dr. D. M.Carter, The Rockefeller University, 1230 York Ave-nue, New York, NY 10021-6399.

RICE UNIVERSITYPOSTDOCTORAL RESEARCH POSMIIONFor studies of regulation of sterol synthesis. Experi-

ence in mammalian cell culture and/or metabolic andbioanalytical studies of sterols and related compoundsdesirable. Salary dependent on qualifications and ex ri-ence. Send resume with names of references to: .JSchroepfer, Jr., Department of Biochemistry, RiceUniversity, P.O. Box 1892, Houston, TX 77251.Rice University is an Equal Opportunity/Afirmative ActionEmployer.

POSTGRADUATE POSITION IN MICROBI-OLOGY to do research in Microbial Coal CleaningSection of the Pittsburgh Energy Technology Center.Project involves isolation of bacteria that remove sulfurfrom model compounds and coal. Graduate degree with-in past 3 years and U.S. citizenship or PRA statusrequired. Contact: Fossil Energy Postgraduate Pro-gram, University Programs Division, Oak Ridge As-sociated Universities, P.O. Box 117, Oak Ridge, TN37831-0117. Telephone: 615-576-3456.

RESEARCH ASSOCIATE on neurotransmitter in-teractions using biochemical and histological techniquesin brain and culture. Ph.D. with experience in cDNAhybridization, immunocytochemistry, RIA, HPLC orcell culture preferred. Stipend $20,000 per year. Excite-ment of expanding neurobiology group. Respond withcurriculum vitae and names of three references to: R. M.Beckstead, Department ofAnatomy and Cell Biology,Medical University of South Carolina, Charleston,SC 29524. Equal Opportunity Employer.

RESEARCH ASSOCIATE (POSTDOCTORAL)available immediately to study the neuronal mechanismsunderlying the behavioral effects of hallucinogens, CNSstimulants and related compounds. The applicant shouldhave a Ph.D. (or ABD) in experimental psychologypharmacology or related biomedical science, knowledgeof drug discrimination methods, and an interest in more"molecular" techniques (neurotoxin lesions, in vivo dial-ysis, etc.) in conjunction with this procedure. Expertisein computer programming and interfacing is desirablebut not mandatory. Send curriculum vitae and threeletters of reference to: James B. Appel, Ph.D., Behav-ioral Pharmacology Laboratory, Department of Psy-chology, University ofSouth Carolina, Columbia, SC29208. The University of South Carolina is an EqualOpportunity/Afirmative Action Employer.

IMI6

POSTDOCTORAL RESEARCH: Biodehalogena-tion, microbial enzymatic, and active site dehalogena-tion reactions: 14C synthesis, metabolism, quantitation ofpathways and kinetics, active site chemistry. Available 1February 1989. Send resume and three letters of recom-mendation to: Dr. C. E. Castro, Nematology Depart-ment, University of California at Riverside, River-side, CA 92521.

YALE UNIVERS1IYRENAL RESEARCH-Department of Cellular and

Molecular Physiology, Investigate ion transport by renalepithelial cells. Research involves the regulation of ionchannels by different hormones and second messengers.

Applicants should have a M.D. or Ph.D. degree withat least 3 years of experience. A background in renal cellseparation and patch-damp technique is essential.

Salary commensurate with qualifications and experi-ence. Applications, with curriculum vitae and the nameof three referees, should be sent to: Dr. G. Giebisch,Department of Cellular and Molecular Physiology,333 Cedar Street, New Haven, CT 06511.

RESEARCH POSITIONThe Universities Space Research Association has an

ongoing need for research scientists and assistants toinvestigate processes or products which are limited oraffected by conditions not shared by the Space and Earthenvironments (e.g., microgravity, high vacuum, etc.).Candidates should be able to quantify these limitationsand effects theoretically and/or experimentally. They willbe expected to: develop theories for various heat andmass transport processes encountered during crystalgrowth and solidification; develop numerical codes andperform analysis on mass redistribution, interface stabil-ity, defect formation in structural, electronic, and opticalmaterials; and/or evaluate the effects of residual gravita-tional forces on materials and processes. Additionally,candidates could provide assistance with ground-basedand flight hardware related to studies to ascertain thepotential benefits of processing materials in space. Workwill be conducted in the Microgravity Sciences Divisionof the Space Science Laboratory, NASA/Marshall SpaceFlight Center. Scientists must have Ph.D. in related field(e.g., Materials Science or Physics). Assistants must haveundergraduate degree in related field. The appointmentwill be for 1 year, renewable. Salary commensurate withexperience (minimum $33,000 per year for scientists)with full medical and retirement benefits. Send resumnto: USRA, Dr. James M. Van Alstine, 4950 Corpo-rate Drive, Suite 100, Huntsville, AL 35806. USRA isan Equal Opportunity/Afirmative Action Employer.

PENNINGTON BIOMEDICALRESEARCH CENTER

BATON ROUGE, LOUISIANAPennington Biomedical Research Center, a newly-

opened modern research facility affiliated with LouisianaState University Medical Center in New Orleans, invitesapplication to fill several RESEARCH POSITIONS inthe Laboratory of Neurosciences. The primary researchgoal of this center is in the area of nutrition.

(1) Senior Neurochemist (one position): The candi-date must have a Ph.D. or M.D. with at least 3 years ofpostdoctoral experience and strong research accomplish-ments. Preference will be given to candidates with experi-ence in nutritional research. Salary and faculty rank willbe commensurate with background.

(2) Research Associate (two positions): The candi-date may have a B.S., M.S., or Ph.D. degree in chemis-try, biochemistry, psychology, or pharmacology withexperience in neurochemical/neuropharmacological re-search. Salary will be commensurate with educationalbackground and experience.

(3) Research Associate in Anatomy (one position):The candidate may have a B.S., M.S., or Ph.D. degree inchemical or biological sciences. Candidates with experi-ence in receptor autoradiography, and brain microdissec-tion techniques. Salary will be commensurate with edu-cational background and experience.

Qualified candidates should contact:Dr. Chandan Prasad

Department of MedicineLSU Medical Center1542 Tulane Avenue

New Orleans, LA 70112-2822LSUMC is an Equal Opportunity/Afirmative Action

Employer.

The Medical College of Wisconsin Department ofOphthalmology invites applications for two filll-time,tenure-track RESEARCH POSMONS at senior andjunior faculty levels. Requires Ph.D. or M.D. with atleast 2 years of postdoctoral research experience and NIHRO1 support. Candidates should have training in one ofthe following areas: cell biology, molecular biology(genetics) or immunology, and an interest in working onclinically relevant problems. Send curriculum vitae, sum-mary of research interests, and names of three referencesto: Search Commnittec, Medical College ofWisconsinEye Insfitute, 8700 West Wisconsin Avenue, Milwau-kee, WI 53226. Affirmative Action/Equal Opportunity Em-ployer M/F/H.

RESEARCH TECHNICIANHOWARD HUGHES MEDICAL INSTrrUTE-

DALLASA position for a research technician is currently avail-

able for aexperienced B.A./B.S. or M.S. histologist/mi-croscopist to join an ongoing investigation (in colabora-tion with Dr. Robert Hammer) of insulin receptorstructure/function in transgenic mice. Experience re-quired includes the preparation of frozen and paraffinsections for immunocytochemistry and immunofluores-cence. Preference will be given to candidates who alsohave experience with in situ hybridization, light micros-copy (bright field, phase, fluorescence) and photomicros-copy. Excellent facilities are available. Send a currentcurriculum vitae and the names of three references to:

Dr. Leland EllisHoward Hughes Medical Institute

University of Texas Southwestern Medical Center5323 Harry Hines Boulevard

Dallas, TX 75235-9050

SUPERVISORY PHARMACOLOGIST ORRESEARCH CHEMIST, GM-14

Supervisory Pharmacologist or Research Chemist,GM-14, to serve as Chief of the PharmacodynamicsTeam, Biochemical Pharmacology Branch, U.S. ArmyMedical Research Institute of Chemical Defense, Aber-deen Proving Ground, Maryland. Responsible for super-vising and managing fundamental research on mecha-nisms of action of toxic agents, and the development ofconcepts ofprophylaxis and therapy. Qualified applicantsmust have established expertise in pharmacokinetic mod-cling, neurotransmitter pharmacology, enzyme kinetics,toxicokinetics or molecular biology as indicated throughpeer reviewed publications. Demonstrated ability to ef-fectively manage and supervise research in the aboveareas is highly desirable. Salary range is $48,592 to$63,172 per annum. Position requires Bachelor's Degree(or higher) in an appropriate discipline and 3 years ofprofessional experience. Ph.D. desired. U.S. citizenship isrequired and the applicant must be able to obtain a securityclearance. Resumes must be received by 15 April 1989and sent to: Commander, U.S. Army Aberdeen Prov-ing Ground Support Activity, Attention: STEAP-PA-CR-D (Ms. Davis), Aberdeen Proving Ground, MD21005-5001. Equal Opportunity Employer.

SUPERVISORY PHARMACOLOGIST ORRESEARCH CHEMIST, GM-15

Supervisory Pharmacologist or Research Chemist,GM-15, to serve as Chief ofthe Biochemical Pharmacol-ogy Branch, U.S. Army Medical Research Institute ofChemical Defense, Aberdeen Proving Ground, Mary-land. Responsible for supervising and managing funda-mental research on mechanisms of action of toxic agents,and the development of concepts of prophylaxis andtherapy. Qualified applicants must have established ex-pertise in biochemical pharmacology as indicatedthrough peer-reviewed publications. Demonstrated abili-ty to efficiently and effectively manage and superviseinterdisciplinary research teams is highly desirable. Salaryrange is $57,158 to $74,303 per annum. Position re-quires Bachelor's Degree (or higher) in an appropriate

scipline and 3 years of professional experience. Ph.D.desired. U.S. citizenship is required and the applicant must beable to obtain a security clearance. Resumes must be receivedby 15 April 1989 and sent to: Commander, U.S. ArmyAberdeen Proving Ground Support Activity, At-tention: STEAP-PA-CR-D (Ms. Davis), AberdeenProving Ground, MD 21005-5001. Equal OpportunityEmployer.

SCIENCE, VOL. 243

POSITIONS OPEN POSITIONS OPEN

\ .\ .

CIBA-GEIGY Animal Health is seekingqualified individuals to fill open positionswithin its BIOVET Unit, a young and dy-namic R & D group established in 1985 topursue product opportunities in animalhealth care based on biotechnology-de-rived materials. Specifically, we look for a

R & D Scientist

with a DVM degree plus a minimum of 2-3years of post-graduate training (such asresidency, industrial experience or a PhD)in the areas of Internal Clinical Medicineand/or Pathology. We also look for a

Postdoctoral Fellow

with a DVM degree plus further training inImmunology or Microbiology.

Candidates for both positions must have athorough knowledge of the livestock in-dustry in North America or Europe and aminimum of one year experience in gener-al veterinary practice. Expertise in datamanagement and statistics is desirable.

The prospective members of the team willbe working in our R & D center situated inthe French-speaking area of Switzerland.They will have the excellent opportunity towork in a highly interactive environmentand to contribute actively to the solution ofpractical problems in animal health care.

Please send your application with docu-mented history under code "Science 239"to Mr. H. Schmid, CIBA-GEIGY Ltd., Per-sonnel Department, P.O. Box, CH-4002Basle.

CIBA-GEIGYi~~~~~~~~~~\ \

The Parke-Davis Pharmaceutical Research Division ofWarner-Lambert, a world leader in pharmaceutical devel-opment, has an immediate opening in the Pathology andExperimental Toxicology Department for a Toxicologist.Requires an outstanding individual with industrial or ac-ademic background and training in experimental toxicol-ogy. This individual will participate in designing, conduct-ing and reporting of various preclinical toxicology studieswith new drug candidates. The successful candidatemust be able to work independently and as a member ofa highly specialized team. This position requires a Ph.D.degree or equivalent in a biological science and 1-3years' experience in toxicology. ABT certification is desir-able.Our research facilities, adjoining The University of Mich-igan campus in Ann Arbor, Michigan, are among the fin-est and best equipped in the world and are devoted ex-clusively to the discovery and development of new drugs.Join the exciting research and development team at War-ner-Lambert and enjoy outstanding compensation andenvironment. Interested, qualified applicants shouldsend their resume and salary requirements in confidenceto: Ms. S. Hultquist, Human Resources Representa-tive, PARKE-DAVIS, 2800 Plymouth Road, Ann Arbor,Ml 48105.

PARKE-DAVISDIVISION OF VARNER LAMBERT COMPANY

"Equal Opportunity in Action"

BUILDING ANEW LAB?

LET THE SCIENCE FREE PRODUCTINFORMATION SERVICE PUT YOU INTOUCH WITH THE VENDORS WHOSEPRODUCTS YOU WILL NEED.

SIMPLY WRITE US A LETTER STATINGTHE SPECIFICS ABOUT YOUR PROPOSEDLAB AND WE WILL DO THE REST.

WRITE TO:

SCIENCE MAGAZINENEW LAB SERVICE DEPT.1515 BROADWAYNEW YORK, N.Y. 10036

I I I

Smith Kline & French Laboratories, a leader in pharmaceuticalresearch, is seeking additional Postdoctoral Scientists to ex-

pand its current research programs. These are exceilent op-

portunities for innovative interdisciplinary research in our newand superbly equipped Research and Development Center insuburban Philadelphia near Valley Forge, PA.The Department of Molecular Genetics is seeking outstandingPh.D. scientists to pursue research in the following areas:

* Molecular genetics of yeast (S. cerevisiae and C. albicans).* Molecular biology of Interleukin I secretion and/or receptor

recognition.

The successful candidates must have:* Ph.D. in Biological Science or related area.* Experience in recombinant DNA techniques.* Experience in Molecular Biology and protein purification is

desirable.

For confidential review, qualified candidates should forwardyour C.V. and names of 3 references to: Barbara J. Schwartz,S0065, Employment Administrator, Smith Kline & FrenchLaboratories, Research & Development, P.O. Box 1539, Kingof Prussia, PA 19406-0939. We are an Equal OpportunityEmployer, M/F/H/V.

U.S. PATENT AND TRADEMARK OFFICEPOSITION: Microbiologist/Patent Examiner Opportunity in-volves the scientific and legal evaluation of patent applica-tions involving recombinant DNA, molecular and cellularimmunology, molecular genetics, microorganisms, cell biolo-gy, cell culture, fermentation, enzymology or clinicalchemistry.QUALIFICATIONS: A full 4-year or longer professional curric-ulum in an accredited college or university leading to aBachelor's Degree or higher with specific study in MolecularBiology, Biochemistry, Immunology, Enzymology, Embryolo-gy, Protein Chemistry, Microbiology or Cell Biology.

A Ph.D. or M.S. degree with relevant research experience ispreferred. A B.S. degree with significant research experiencewill be considered.

Research Experience in any of the following areas would bebeneficial: DNA cloning, protein chemistry, gene expression,sequencing techniques, muteins, hybridoma technologies,monoclonal antibody applications, mammalian or plant celllines, cell culture, immunossays, hybridization techniques,fermentation, enzymatic reaction, diagnostics and automationof clinical analysis.SALARY: Dependent upon experience and qualifications.LOCATION OF POSITION: Arlington, VA

For further information contact:Patent and Trademark OfficeOffice of Personnel, C&ECPK 1, Suite 700Washington, D.C. 20231703-557-3631Toll free: 800-368-3064

DEPARTMENT OF HEALTH AND HUMAN SERVICESAlcohol, Drug Abuse, and Mental Health Administration

U.S. Public Health ServiceNational Institute of Mental Health

Deputy Division DirectorThe Division of Basic Sciences has an immediate opening for a

supervisory health scientist administrator to serve as Deputy Director ofthe Division. The Division supports a broad range of research inneurosciences and behavioral sciences through grants and contracts touniversities, hospitals, and other research organizations. The Division hasan annual budget of approximately $70 million, which supports research,research development, and research training activities, and has a staff ofabout 40. The Deputy Director assists the Director in the scientific andadministrative management of the Division, and in the evaluation anddevelopment of basic research programs related to mental illness.Therefore, a broad knowledge of the scientific fields represented byDivision programs is essential.Applicants should possess an M.D. or a Ph.D. degree, or equivalent

training, in a discipline related to neuroscience or behavioral science, andshould have extensive experience in direct research as well as researchadministration. The position will be filled through the Civil Service orCommissioned Corps of the U.S. Public Health Service. The grade of theposition is a GM-15, with a salary range from $57,158 to $75,500 perannum. Benefits include a retirement plan, health and life insurance, sickand annual leave. Relocation expenses may be paid. Duty station isRockville, MD. U.S. citizenship is required.Any applicant not currently employed in the Federal Government will be

required to obtain an eligible notice of rating.Submit applications for Federal Employment (SF-1 71) and curriculum

vita to Ms. Benesch, Division of Personnel Management, Room 15C-12,5600 Fishers Lane, Rockville, MD 20857, (301)443-5407. Applicationsmust be postmarked no later than May 1 2, 1989.

ADAMHA is an Equal Opportunity Employer

ImmunologistPfizer Central Research has an opening in its immuno-therapy research group for an immunologist interested inparticipating in the discovery of new immunostimulatoryagents. You will join a multidisciplinary team of scientistsworking in state-of-the-art research facilities. Our currentinterests encompass the pharmacologic manipulation ofT-cells. macrophages, and/or hemopoeitic stem cells inpatients at increased risk of infection.You must have a PhD and postdoctoral training inimmunobiology or immunochemistry with an emphasis onmechanisms of cellular activation and a documentedrecord of accomplishment. Areas of research interest couldinclude receptor-ligand interactions. second messengersystems or maturational processes. Previous industrialresearch experience is welcome but not essential.This position offers excellent opportunities for profession-al recognition and development. We offer an excellent sa-lary. benefit and relocation package plus an attractivesoutheastern Connecticut shore location. Qualified appli-cants should submit their resume, including the names,addresses and phone numbers of three professional refer-ences, to: J.K. Larson, PhD, Assistant Director, EmployeeResources, Pfizer Central Research, Eastern Point Road,Groton, CT 06340. An equal opportunity employer.

I

Scientists

factivelyimpactingonbreaktbrougbsin

biotec/,nologyis whatYou/iaveinmind,

cometoScbering-Plog/i.

We have immed iate chal lenges with i nour Biotechnology Group in Union,New Jersey for innovative scientificthinkers who would like to participatein one of today's most exciting andsignificant areas of health care, withopportunities to impact on the areasof cell culture development and rDNAtechnology.This is an outstanding opportunity toenhance your own considerable exper-tise while supporting scale-up ofrecombinant protein expression inmammalian cells. Your involvementwill include maintaining and charac-terizing cell cultures, as well as per-formingvarious cell biology/physiologystudies. You should have a BS or MS inBiochemistry, Cel I Biology or a closelyrelated field providing in-depth under-standing of cell biology. Backgroundmust include 1-7 years hands-on expe-rience, preferably in an industrial set-ting, using advanced techniques inmolecular biology and analytical pro-cedures for detecting proteins.As partof a $3-billion pacesetter inthe health care industry, you'll receivethe support to pursue your best ideas,as well as an attractive salary and fullbenefits package. For immediate, con-fidential consideration, forward yourresume and salary history to: Mr.Michael Urdanick, Schering-PloughCorporation, 1011 Morris Avenue,Union, NJ 07083. We are an equalopportunity employer.Wh1atyetouahveirnmid, wepu0^tifactiom

q§3 Schering-Plough

I I

-ill

Phanaceullcal ResearchThe Parke-Davis Pharmaceutical Research Di-vision of Warner-Lambert has an excellent ca-reer opportunity for a creative and energeticScientist to join our Biochemistry Section asGroup Leader in Molecular Biology. The suc-cessful candidate will lead a growing group ofPh.D. and assistant scientists in a highly inter-active environment, providing enabling technol-ogy for various drug discovery efforts. Our labs,recently equipped for state-of-the-art DNA syn-thesis and sequencing, peptide synthesis, andamino acid analysis, provide an exciting envi-ronment for basic and applied research whichwill be complemented by interaction with collab-orators in leading academic laboratories and bi-otechnology companies.Qualifications should include:* Ph.D. in Molecular Biology/Biochemistry* At least 4 years' postdoctoral experience inmodern molecular biology

* Experience in cardiovascular pharmacology,especially lipoproteins and atherosclerosis,preferred

* Experience in protein separation and purifi-cation desired

* Effective oral, written and interpersonal skillsResponsibilities will be:* Supervision of studies applying all aspects ofmodern molecular biology technologies todrug discovery

* Isolation and purification of therapeuticallyrelevant proteins

* Interact with other biochemists, biologists,medicinal chemists and pharmacologists in-volved in ongoing drug discovery efforts

* Liaison with senior molecular biologists in-volved in drug discovery at collaboratingleading biotechnology laboratories

We offer excellent compensation and benefitsat our modern facilities adjacent to the Univer-sity of Michigan campus. Qualified applicantsshould send curriculum vitae in confidence to:Ms. S. Hultquist, Human Resources, Parke-Davis Pharmaceutical Research Division,Warner-Lambert Company, 2800 PlymouthRoad, Ann Arbor, Ml 48105.

PARKE-DAVISDIVISION OF VARNER LAMBERT COMPANY

"Equal Opportunity in Action"

-

POSITIONS OPEN

SABBATICAL REPLACEMENT. Organic area.Assistant professor for 1 year with possible extension to 2years beginning August, 1989. Ph.D. required. DenisonUniversity is a high-quality liberal arts college located incentral Ohio. This ACS-certified departmnent has excel-lent facilities for teaching and research including modeminstrumentation. Primary responsibilities will be in theorganic area but participation in the general chemistryprogram will also be expected. Some experience in thebiochemistry area would be helpful. A strong commit-ment to undergraduate teaching is required. Interestedapplicants should send letter of application, resume,transcripts, and three letters of recommendation by 31March 1989 to: Dr. Richard R. Doyle, Chairman,Department ofChemistry, Denison University, Gran-vile, OH 43023. An Equal Opportunity Employer. Womenand minorities are encouraged to apply.

A full-time STAFF SCIENTIST position is availableto study molecular biology of signal transduction inplants. Candidates must have a Ph.D. in plant science andat least five publications in peer-reviewed professionaljournals evidencing experience in signal transduction inplants. Postdoctoral experience in calcium research as itrelates to signal-induced processes as well as experience inrecombinant DNA techniques are required. Salary range$30,000 to $36,000 per year. Submit curriculum vitae, alist of publications, and three letters of reference by 20April 1989 to: Professor B. W. Poovaiah, Departmentof Horticulture and Landscape Architecture, Wash-ington State University, Pufilman, WA 99164-6414.WSU is an Equal Opportunity/Afirmative Action educator andemployer. Protected group members are encouraged to apply.

SUPERVISORY NEUROSCIENTISTGM-14

To serve as Research Team Leader, NeurotoxicologyBranch, U.S. Army Medical Research Institute of Chem-ical Defense, Aberdeen Proving Ground, Maryland. Re-sponsible for supervising, managing and conductingresearch on either (i) the molecular mechanisms of actionof neurotoxic threat agents or (ii) the effects of neurotox-ic agents on the integration of neural events, systemfunction and behavior. Research is focused on biologicaltoxins (e.g., saxitoxin, brevetoxin, etc.), and the develop-ment of concepts of prophylaxis and therapy. Qualifiedapplicants must have established expertise in electrophys-iology, membrane biophysics, neuropharmacology, inte-grative neural systems, experimental psychology and/orneurotoxicology as indicated by peer-reviewed publica-tions. Demonstrated ability in multidisciplinary researchprogram planning and administration is highly desirable.The ideal candidate will have a Ph.D. in one of the basicanimal sciences, physiology, pharmacology, psychology,or a closely related discipline. Salary range is $48,592 to$63,172 per annum. U.S. citizenship is required and theapplicant must be able to obtain a security clearance. Resu-mes must be received by 17 April 1989. Send to: Com-mander, U.S. Army Aberdeen Proving Ground, At-tention: STEAP-CP-RT (Ms. C. Davis), AberdeenProving Ground, MD 21005-5001. Equal OpportunityEmployer.

SUPERVISORY NEUROSCIENTISTGM-15

To serve as Chief of the Neurotoxicology Branch,Pathophysiology Division, U.S. Army Medical ResearchInstitute of Chemical Defense, Aberdeen ProvingGround, Maryland. Responsibilities include supervisingand managing research on the mechanisms of action ofneurotoxic threat agents with particular emphasis onbiological toxins (e.g., saxitoxin, brevetoxin, etc.). Thegoals of these research initiatives are the development ofeffective medical treatment regimes for threat agents.Qualified applicants should have a background in neuro-physiology, neuroanatomy, neuropharmacology, experi-mental psychology and neurotoxicology as indicated bypeer-reviewed publications. Demonstrated ability in mul-tidisciplinary research program planning and administra-tion is highly desirable. The ideal candidate will have aPh.D. in one of the basic animal sciences, physiology,pharmacology, psychology, or a closely related discipline.Salary range is $57,158 to $74,303 per annum. U.S.citizenship is required and the applicant must be able to obtain asecurity clearance. Resumes must be received by 17 April1989. Send to: Commander, U.S. Army AberdeenProving Ground, Attention: STEAP-CP-RT (Ms. C.Davis), Aberdeen Proving Ground, MD 21005-5001. Equal Opportunity Employer.

POSITIONS OPEN

mCtSCIENCE ITEM WRITERS

Opportunity for present or former science teachers(undergraduate college experience preferred) to workpart-time at home writing questions for a testing pro-gram administered nationally by The American CollegeTesting Program (ACT). In addition to a strong back-ground in science, the work requires precise writing tomeet exacting standards.

For additional information, write as soon as possibleto: Editorial Manager, Test Development Depart-ment (S), ACT National Office, 2201 North DodgeStreet, P.O. Box 168, Iowa City, IA 52243. Pleaseidentify areas of specialization-biology (botany, zoolo-gy), chemistry (general, biochemistry), physics, or physi-cal science. Include resume to indicate formal educationand teaching experience.

ACT is an Equal Opportunity/AffirmativeAction Employer.

(j)TRATAGENETECHNICAL SALES REPRESENTATIVE

Stratagene, a rapidly growing innovative supplier ofmolecular biology research products, currently has anopening for qualified and experienced technical salesrepresentatives. Immediate openings are available in theSouthern California and Midwest areas. These positionsrepresent a unique opportunity for qualified individualsto participate in a growing technical sales organization.Candidates should have strong practical experience inmolecular biology, and a B.S. degree in molecular biolo-gy or related field. Prior sales experience is beneficial.Please forward resume of qualifications to: Stratagene,Attention: Kim Brown/Personnel, 11099 North Tor-rey Pines Road, Lajolla, CA 92037.

The Division of Nutritional Sciences at Cornell Uni-versity invites applications for TWO TENURE-TRACK POSMONS in nutritional biochemistry/mo-lecular genetics/cell biology. Candidates should have adoctoral degree, postdoctoral experience, and demon-strate potential for outstanding accomplishments in re-search and teaching.The Division of Nutritional Sciences is a broadly

based interdisciplinary unit of 38 tenure-track facultyconcerned with the chemical, biological, clinical, andsocial science aspects of nutritional science. The success-ful candidates would be expected to have or developstrong research programs suitable for graduate studenttraining in basic sciences, e.g. mammalian metabolism,and to participate in the Division's undergraduate andgraduate teaching program. Initial appointments will bemade at the rank and salary indicated by the qualifica-tions of successful candidates. Screening will begin 1May 1989 and continue until the positions are filled.Send application with resume and the names and ad-dresses of at least three references to: Dr. Michael N.Kazarinoff, 230 Savage Hall, Cornell University, Ith-aca, NY 14853.

TOXICOLOGIST (436488) $469.20 to $646.40per week. The Department of Agriculture, Food andRural Resources is recruiting qualified candidates to fillan immediate vacancy in the Board of Pesticides Controlin Augta, Maine. This is professional work in theidenti cation of health hazards due to pesticides in theair, water and land. Minimum qualifications are an 8-yearcombination of education, training and experience withprimnary emphasis in toxicology. An example of an ac-ceptable combination of trainmg and experience wouldbe a Bachelors degree in toxicology, epidemiology, bio-chemistry or directly related and 4 years of experience intoxicology, pesticides, or directly related field. Preferencewill be given to candidates with experience in performingand/or interpreting chemical analyses of pesticides. Ap-plications and Supplemental Qualifications Question-naires available at the Bureau of Human Resources andJob Service Offices must be submitted to: The Bureau ofHuman Resources, State Office Building, Station 4,Room 214, Augusta, ME 04333 no later than 5:00p.m. on 3 April 1989. An Equal Opportunity/AffirmativeAction Employer M/F/H.

POSITIONS OPEN

SYSTEMATIC ENTOMOLOGISTAssistant Professor/Assistant Curator, Departments of

Entomology, Systematics and Ecology, and Snow Ento-mological Museum. Tenure-track, 9-month appoint-ment, expected starting date 27 August 1989. Dutiesinclude: (i) productive research in systematic entomolo-gy; (ii) enhance collections and programs of SnowEntomological Museum; (iii) teaching graduate andundergraduate courses in entomology or biological sci-ences; (iv) promote and direct graduate student research.Required qualifications: (i) Ph.D. in insect systematics orclosely related field; (ii) evidence of ability to: communi-cate ideas effectively; carry out a vigorous research andfield program; (iii) familiarity with appropriate curatorialprocedures; (iv) comnmitment to excellence in research,graduate training and teaching.

Applications, including curriculum vitae; publications,manuscripts, grant applications; statement of researchinterests, goals and activities; teaching philosophy andexperience, and courses the candidate would like toteach-and three letters of recommendation should besent by 31 March 1989 to: Dr. James S. Ashe, SnowEntomological Museum, Snow Hall, University ofKansas, Lawrence, KS 66045; telephone: 913-864-3065.

Equal Opportunity Employer/Affirmative Action.

University of California, Los Angeles (UCLA) Urolo-gy Division seeks Board-certified UROLOGIST withexpertise in renal transplantation for faculty position.Requirements: proven ability to organize clinical train-ing; ability to collaborate in immunology research; expe-rience in reconstructive and pediatric urology; excellentsurgical skills. Applicants should contact: The UCLADivision of Urology, Los Angeles, CA 90024-1738.UCLA is an Equal Opportunity/Affirmative Action Employer.

VICE PRESIDENT FORACADEMIC AFFAIRS

WESLEYAN UNIVERSITYApplications and nominations are invited for the posi-

tion of Vice President for Academic Affairs at WesleyanUniversity. Wesleyan University is best known for liberalarts undergraduate education and graduate divisionsemphasizing the Arts and Humanities, and the Social andNatural Sciences. There are 2800 students and 353faculty. Wesleyan also has a respected Graduate LiberalStudies Program. Wesleyan prides itself on aid-blindadmissions and its faculty and student body reflect adiversity of ethnic, cultural, and geographical back-grounds.

In creative partnership with the President, the VicePresident for Academic Affairs will be the principaladministrative officer concerned with shaping education-al priorities. Responsibilities will include reviewing andguiding curricular development and educational bud-gets; presiding over faculty organization and develop-ment, including recruitment, promotion, and retention;and attracting, allocating, and monitoring external fund-ing. The successful candidate will have a record ofaccomplishment in teaching, research, and leadership.

Applicants should send a personal statement of interestand qualifications along wit-h a complete resurnm and thenames of three references to:

Professor Jill Morawski, ChairSearch Committee-Vice President for

Academic AffairsProvost's Office, North College

Wesleyan UniversityMiddletown, CT 06457

Applications received by 31 March 1989 will beassured full consideration.An Equal Opportunity and Affirmative Action Employer.

PROGRAM

CAREER CHANGE OPPORTUNITYThis unique program offers the candidate with an

eamed doctorate in the sciences the opportunity toobtain the Doctor of Optometry (O.D.) degree in twocalendar years. Employment opportunities exist in pri-vate practice, industry, education and research. Contact:Dr. D. Chauncey, Program Director, AcceleratedProgram, The New England College of Optometry,Room S, 424 Beacon Street, Boston, MA 02115.

SCIENCE, VOL. 243I520

Adress inquiries, with a photograph to PUBLIVAL/202027, Route des Gardes - 92190 MEUDON (FRANCE)

The Department of Pharmacology of Smith Kline & French Laboratories,located in suburban Philadelphia, Pennsylvania, is seeking outstandingscientists to expand its current research programs in cerebrovascularpharmacology and stroke. The individuals will be involved in amultidisciplinary research effort focused on mechanistic studies of brainischemia and its pathogenesis as directed toward the discovery of noveltherapeutic strategies for treatment of stroke.Successful candidates will have:* a Ph.D. in Pharmacology, Physiology, Biophysical or Neuroscience

with at least 3 years postdoctoral experience in cardiovascular/cerebrovascular related research

* experience in neurochemical methods, including neurotransmitterassays (RIA, HPLC), is desired. Experience in culture of neuronal/glial cells is most advantageous

* a strong publication record* good oral and written communication skills* demonstrated ability to interact with a multidisciplinary research team

We offer excellent compensation and benefits as well as an attractiverelocation policy. For confidenfial consideration, send your C.V. andnames of three references to Barbara J. Schwartz, S0092, EmploymentAdministrator, Smith Kline & French Laboratories, Research andDevelopment Division, P.O. Box 1539, King of Prussia, PA 19406-0939.We are an Equal Opportunity Employer, M/F/H/V.

International Conference on Metalsin Soils, Waters, Plants and AnimalsApril 30 - May 3, 1990Orlando, Florida

Organized by the University of Georgia's Savannah River EcologyLaboratory, the conference will provide a forum for the disseminationof current knowledge concerning the sources, pathways, behavior,fate, and effects of metals and metalloids in the environment. Oralpresentations, posters, keynote speakers, and panel discussions willfocus on the following themes:

* Contamination of soils, plants, surface water, andgroundwater

* Behavior and interchange at soil-plant, plant-atmosphere,and sediment-water interfaces

* Pathway/transport phenomena* Bioavailability as affected by chemical speciation, soilamendments, mitigation, and other factors

* Biotransformation* Accumulation, acclimation, and toxicity in organisms* Food chain transfer* Effects of acid precipitation on metals in the environment* Speciation and modeling applications* Modern measurement techniques* Metal-waste management* Regulatory criteria and guidelines* Risk/health assessment

Field trips and workshops related to the above themes are alsoplanned. The proceedings of the conference will be published.

For further information and the Call for Papers, contact:

Dr. Domy C. Adriano, Conference DirectorInternational Conference on MetalsSavannah River Ecology LaboratoryDrawer EAiken, South Carolina 29802 USA(803) 725-2472

AIDS RESEARCH AT THE NATIONALINSTITUTES OF HEALTH

DIRECTOR OF PROTEIN EXPRESSIONLABORATORY

The Office of the Director of the National Institutes ofHealth seeks a senior scientist to direct the Protein Expres-sion Laboratory at the campus in Bethesda, Maryland. Theprincipal function of this new laboratory will be to expressand purify HIV proteins in large quantities for structural,biochemical, and pharmacological studies. This Laboratorywill be part of the existing effort at the NIH to developtherapeutic agents, based on structural and mechanisticconsiderations, that will interfere with the HIV life cycle. TheDirector of the Protein Expression Laboratory will be ex-pected to recruit additional senior scientists, post-doctoralfellows, and technicians.

Requirements include a Ph.D. in Molecular Biology orBiochemistry, at least three years of post-doctoral expe-rience, expertise in the use of recombinant DNA techniquesfor the expression of proteins, as well as expertise in thepurification of proteins. Salary is negotiable, dependentupon experience.

Interested candidates should send a curriculum vitaeandnames and telephone numbers of at least 3 references to:

0_ I/VS> Dr. Joseph E. Rail

o+ o, Deputy Director for Intramural Researchi)0<& gBuilding 1, Room 126

z Jco National Institutes of Health^+ 9000 Rockville Pike

HEt\ Bethesda, Maryland 20892The National Institutes of Health, which is located 10 miles

from the center of Washington, D.C., is the largest biomedi-cal research institution in the world, and is an EqualOpportunity Employer.

The research center of the largest pharmaceu-tical company in FRANCE is strengthening anddiversifying its capabilities:

MEDICAL CHEMISTSorganic synthesis:* heterocyclic* lipid and peptide analogs

PHARMACOLOGISTS* inflammation,* pulmonary, diabetology,* rheumatology,* cardio-vascular diseases

You are scientists dedicated to the invention of newmedicines with a post graduate degree anddemonstrated achievement in applied research.Some positions involve direction of a group while others offerprofessional development to entry level research scientists.Our research center is located in the attractivewestern outskirts of Paris.

II II

9 1:4

FELLOWSHIPS

DOCTORAL PROGRAM IN MOLECULAR,CELLULAR, AND SYSTEMS PHYSIOLOGY. Ourgraduate program offers coursework and research train-ing leading to the Ph.D. in physiology. The Departmentis well-known for its research activities in a number ofareas, including muscle and cardiovascular physiology.Investigators in the Department employ physiological,biochemical, biophysical, and molecular biological tech-niques to elucidate the function of biological systemsfrom the level of organ systems to the level of individualbiological molecules. Financial support is available toqualified applicants with appropriate undergraduatetraining. For further information, contact: Dr. HowardKutchai, Box 449, University of Virginia HealthSciences Center, Charlottesville, VA 22908 or tele-phone him at 804-924-2195. We are an Equal Opportuni-ty Employer.

GRADUATE FELLOWSHIPS IN BIOCHEM-ISTRY, ANATOMY OR PHYSIOLOGY are avail-able for research studies in the Regulatory PeptideCenter of the Department of Biomedical Sciences,Creighton University, Omaha, NE 68178, starting inthe fall of 1989. The applicant should state the disciplineof interest when requesting further information from theDepartment Chairman. CU is an Equal Opportunity/Af-firmative Aaion Employer.

POSTDOCTORAL FELLOWSHIPS IN CAR-DIOVASCULAR SCIENCES. Positions are availablefor advanced studies in cardiovascular physiology, phar-macology, and pathology at the University of Virginia.A strong multidisciplinarv program with eleven investi-gators provides a wide-range of experimental techniquesand conceptual models ranging from studies on controlof ANF in the intact animal to the molecular biology ofthe renin-angiotensin system. Applicants should applyto: Dr. Brian R. Duling, Department of Physiology,Health Sciences Center, University of Virginia, Char-lottesville, VA 22908. We are an Equal OpportunityEmployer.

POSTDOCTORAL RESEARCH TRAININGFELLOWSHIPS

Fellowships available to residents of North Americawith Ph.D., M.D., or comparable degree and less than 1vear of postdoctoral laboratory experience by applicationdate for beginning training in basic biomedical research.The 3-vear award consists of a stipend of $20,000 for thefirst year, with increments of $1,000 for each of the next2 years; $1,000 per annum research allowance; travel tofellowship location; annual meeting. Application dead-Line 15 August 1989; fellowships activate following July.For appLication forms, write or telephone: The HelenHay Whitney Foundation, 450 East 63rd Street, NewYork, NY 10021; telephone: 212-751-8228.

RESEARCH DEVELOPMENT AWARDS ATTHE NATIONAL ZOOLOGICAL PARK

The National Zoological Park (NZP) is offering Re-search Fellowships for scientists to complete a majorpiece ofwork in their specialty, and to gain experience inresearch opportunities specific to zoological parks partic-ularly in the areas of evolutionary biology, animal behav-ior, physiological zoology, ecology, sociobiology, repro-ductive physiology, conservation biology, and veterinarysciences. Applicants with a distinguished record of re-search contributions and those whose interests comple-ment the NZP's current professional research staff arepreferred.Each award is for a maximum of 3 years; stipends to

be commensurate with professional level and experience.Applicants must be at least 3 years postdoctorate. Timingand duration of the Fellowships are flexible, but theappointment must be activated within a year of theaward and may not exceed a total of 36 months induration (awards may be divided into several intervals,not less than 6 months each).

Field research is appropriate; however, Fellows are tobe primarily based at the NZP to maximize interactionsand collaborations with NZP staff. Individuals who havereceived support from or through the NZP for a signifi-cant period during the preceding 5 years are ineligible toapply.For information contact: Dr. Devra G. Kleiman,

Assistant Director for Research, National ZoologicalPark, Washington, DC 20008. Application deadline is1 July 1989.

FELLOWSHIPS

WASHINGTON UNIVERSITYCENTER FOR CELLULAR ANDMOLECULAR NEUROBIOLOGY

The Washington University Center for Cellular andMolecular Neurobiology is pleased to announce theavailability of a limited number of FELLOWSHIPSfor advanced postdoctoral work in neurobiology. Theobject of these special awards is to enable outstandingyoung scientists to perform collaborative research in oneor more laboratories associated with the Center. Fellowswill be paid an annual salary based on years ofexperience.A list of faculty associated with the Center and theircurrent research interests is available on request. Once aresearch sponsor is identified a formal application will bereviewed. Requests should be addressed to:Center for Cellular and Molecular NeurobiologyDepartment ofAnatomy and Neurobiology,

Box 8108Washington University School of Medicine

660 South Euclid AvenueSt. Louis, MO 63110

An Equal Opportunity/Affirmative Action Employer.

CONFERENCEANNOUNCING AN NIH CONFERENCE

Modeling in Biomedical Research: An Assessmentof Current and Potential Approaches

Applications to Studies inCardiovascular/Pulmonary Functions and DiabetesTo be held 1 to 3 May 1989, in Masur Auditorium,

The Warren Grant Magnuson Clinical Center, NationalInstitutes of Health, Bethesda, Maryland.

Sponsored by the Division of Research Resources, theDivision of Research Services, and the Office of MedicalApplications of Research of NIH.

Continued innovation and refinement of model sys-tems is crucial to rapid progress in biomedical research.This conference continues NIH's evaluation of model-ing, from the use of non-human primates and inverte-brate species to cell cultures and mathematical andphysical approaches. To emphasize the use ofmany typesofmodels to solve basic biomedical questions, the confer-ence will focus on two areas of great importance to thenation's health: cardiovascular/pulmonary function (1May 1989) and diabetes (2 May 1989).

Scheduled presenters on 1 May include: J. I. E.Hoffman, M. Gimbrone and F. Dewey, N. Staub, S.Factor and R. S. Chadwick, C. Peskin, S. Wickline, R.Ruffolo, and K. Brown and R. Robertson. Those on 2May include: J. Roth, G. Grodsky, 0. M. Rosen, D.Greene, A. Rossini, P. Lacy, R. Bergman, and J. Fain.A panel of scientists chaired by Dr. Gordon H. Sato,

Director of W. Alton Jones Cell Science Center, willquestion the presenters, prepare a summary statement ofthe material presented, and evaluate the strengths andlimitations of the various model systems. On 3 May1989, the panel will present its draft statement and invitecomments from the audience.To register for the conference or obtain further details,

contact: Susan Wallace, Prospect Associates, Suite500, 1801 Rockville Pike, Rockville, MD 20852;telephone: 301468-6555.

SYMPOSIUM60TH ANNIVERSARY SYMPOSIUM OF

THE JACKSON LABORATORYIN HONOR OF

DR. ELIZABETH S. RUSSELLGERM CELLS, PIGMENTATION

AND ERYTHROPOIESIS14 to 16 June 1989Speakers include:

Jane Barker Ed GeisslerAlan Bernstein Mary Ann HandelMurray Brilliant David HarrisonVerne Chapman Nancy JenkinsNeal Copefand Harvey LodishEva Eicher Peter RigbyJohn Eppig Lianne RussellEugene Goldwasser Oliver Smithies

And othersRegistration fonns may be obtained from:

Ruth Mealey, Symposium CoordinatorThe Jackson LaboratoryBar Harbor, ME 04609

CALL FOR PROPOSALS

U.S. Environmental Protection Agency: HHAG/OHEA and HERL/OHR invite PROPOSALS FORCOOPERATIVE AGREEMENTS on biologically-based dose-response modeling for developmental toxici-ty. Project is part of Office of Research and Develop-ment's efforts to support development of improvedhealth risk assessment procedures. Proposals should at-tempt to incorrate basic mechanistic/site of actioninformation and pertinent information on processes thatinfluence chemical action. Integration ofthis informationwith pharmacokinetic/pharmacodynamic interactions attarget site may provide more accurate estimates ofhumanrisk. Consideration of other factors also important indevelopment of dose-response models such as thresholdconcept, the number, size and spread ofdose groups, andeffect of timing and duration of exposure on the out-come. Approaches should include some means of verify-ing the model at doses below observable dose range instandard Segment II studies. Preference will be givenproposals including integrated approach to problem.First year effort expected to involve development ofbackground inforrnation and strategy(ies) for approach-ing problem, with subsequent years devoted to develop-ing models, collection of additional animal data, andvalidation procedures. Possibility of interaction with on-going research efforts at EPA or other federal labs may beconsidered. Preproposals (seven to ten pages) to outlineapproach, provide cost estimates, staff qualifications/ca-pabilities of organization(s) involved. Following reviewof preproposals, selected applicants will be asked tosubmit final proposals. EPA anticipates making one ortwo awards for project periods of 3 to 5 years; $160,000total this year. 14 April 1989 deadline for submission ofpreproposals to: Dr. Carole A. Kimmel, U.S. Environ-mental Protection Agency, 401 M Street, S.W. (RD-689), Washington, DC 20460. Telephone: 202-382-7331. More information on research goals and scopeavailable from Dr. Kinumel or Dr. Kavlock 919-541-2326. This solicitation is subject to Parts 30 and 40 ofEPA Grant Regulations, therefore profit-making organi-zations are prohibited from applying. EPA reserves theright not to make any awards from this solicitation.

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