personalized medicine and you!
DESCRIPTION
Realize preventive medicine through predictive risk profiling, determining baseline markers of wellness and variability, and engaging in personalized pre-clinical interventionsTRANSCRIPT
Personalized Medicine and You!
Melanie Swan Founder
DIYgenomics+1-650-681-9482
@DIYgenomics www.DIYgenomics.org
Health Technology Forum
September 27, 2012, San Francisco, CA
Slides: http://slideshare.net/LaBlogga
September 27, 2012DIYgenomics.org 2
The Realization of Preventive MedicineCondition Lifecycle
80% Pre-Clinical 20% Clinical
Telemedicine
eHealth Initiatives
Social Health Media
Higher-deductible insurance
Consumer Genomics
Health Social Networks
Health Collaboration Communities
Crowdsourced Health Studies
Personal Health Records (PHRs)
Mobile Health Apps
Quantified Self-tracking Devices Biosensors
Participatory Medicine
Hospital Re-admit Reduction Programs
Personalized Molecular
Diagnostics
Wellness Profiling
Disease Risk Prevention
Personalized Cancer
TreatmentHealth Coach
P4 Medicine
(Light) Engagement (Heavy)
Home Monitoring Programs
Swan, M. Health 2050: The Realization of Personalized Medicine through Crowdsourcing, the Quantified Self, and the Participatory Biocitizen. J Pers Med 2012, 2(3), 93-118.
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Health Social Networks and Collaboration
Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525.
Health Collaboration Communities
Health Social Networks
September 27, 2012DIYgenomics.org 4
DIYgenomics: Research Model
Goal: preventive medicine Realize preventive medicine through predictive risk profiling,
determining baseline markers of wellness and variability, and engaging in personalized pre-clinical interventions
Generalized hypothesis One or more polymorphisms may result in out-of-bounds
baseline levels of phenotypic markers which may be ameliorated through personalized intervention
Genotype Phenotype Intervention Outcome+ + =
Source: Swan, M., Hathaway, K., Hogg, C., McCauley, R., Vollrath, A. Citizen science genomics as a model for crowdsourced preventive medicine research. J Participat Med. 2010, Dec 23; 2:e20.
Vitamin B Study: MTHFR SNPs + Vitamin B & Homocysteine Blood Test + Vitamin B = Personalized Outcomes
September 27, 2012DIYgenomics.org
Big Data: Integrating Health Data Streams
5Swan, M. Health 2050: The Realization of Personalized Medicine through Crowdsourcing, the Quantified Self, and the Participatory
Biocitizen. J Pers Med 2012, 2(3), 93-118.
Genome SNP mutations
Structural variationEpigenetics
Microbiome
Transcriptome
Environmentome
Metabolome
Diseasome
Proteome
Personal and Family Health History
Prescription History
Lab Tests: History and Current
Demographic Data
Self-reported data: health, exercise,
food, mood journals, etc.
Biosensor Data Objective Metrics
Quantified Self Device Data
Mobile App Data
Quantified Self Data Streams
Traditional Data StreamsNew Data Streams
Standardized Instrument Response
Legend: Consumer-available
September 27, 2012DIYgenomics.org 6
Sensor Mania! Wearable Electronics
Source: Swan, M. Sensor Mania! The Internet of Things, Objective Metrics, and the Quantified Self 2.0. J Sens Actuator Netw 2012, submitted.
The Brain: 24/7 Consumer EEG, Eye-tracking, Emotion Mapping, Augmented Reality Glasses
Smartwatch (Pebble) and Smartring (ElectricFoxy)Electronic tattoos (mc10), $1 blood API (Sano
Intelligence), and Electronic T-shirt (Carre)Dried blood spot testing (ZRT Lab)Continuous Monitors (Medtronic)
Image credit: Cisco
September 27, 2012DIYgenomics.org
DIYgenomics Memory Study
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Operated on:
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13 DIYgenomics Studies in Open Enrollment
Source: Swan, M. Sensor Mania! The Internet of Things, Objective Metrics, and the Quantified Self 2.0. J Sens Actuator Netw 2012, submitted.
Sleep, Genomics, and Caffeine 20 sleep SNPs + 3 standardized sleep
instruments + myZeo + caffeine intervention
Empathy OXTR SNP + IRI (Interpersonal Reactivity Index)
+ Personal Virtual Coach
Microbiome Human gut disease risk SNPs + Microbiome
Sequencing + Questionnaire + Probiotic
Diabesity prevention Diabetes & obesity risk SNPs + Hemoglobin &
other blood tests + Glucometer tracking
Genotype Phenotype Intervention Outcome+ + =
Full List: http://ww.DIYgenomics.org
September 27, 2012DIYgenomics.org
DIYgenomics Studies in Design
Predictive Risk Profiling Immune System and Diseasome Environmentome (Body Burden and Capacity) Cancer Risk and Drug Response
Mental Performance Optimization Creativity Learning Flow State
Diabesity Prevention Do you have a Sweet Tooth? Genomics and Dietary Preference
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Genotype Phenotype Intervention Outcome+ + =
Image credit: http://sciencemag.org
Source: DIYgenomics
September 27, 2012DIYgenomics.org 10
Personalized Preventive Medicine and You!
Individual
2. Peer collaboration and health advisors
Health social networks, crowdsourced studies, health advisors, wellness coaches, preventive care plans,
boutique physicians, genetics coaches, aestheticians, medical tourism
3. Public health systemDeep expertise of traditional health system
for disease and trauma treatment
1. Continuous health information climate Automated digital health monitoring, self-tracking devices, and mobile apps providing personalized recommendations
Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525.
September 27, 2012DIYgenomics.org 11
DIYgenomics Press Coverage
"...'accelerating the professionalization' of do-it-yourself studies" - March 2012
"Ordinary people are taking control of their health data" - December 2011 "A group called DIYgenomics has banded together to analyse their genomes, and even conduct and participate in small clinical trials" - October 2010
"...early adopters are showing how empowering and beneficial to science personal genetic information can be" - September 2010
"...they wanted to build a model trial that could be easily replicated by citizen scientists anywhere" - March 2011
Thank you!
Melanie SwanFounder
DIYgenomics+1-650-681-9482
@[email protected]: http://slideshare.net/LaBloggaCreative Commons 3.0 license
Collaborators:
Lorenzo Albanello
Janet Chang
Cindy Chen
John Furber
Hong Guo
Kristina Hathaway
Laura Klemme
Priya Kshirsagar
Lucymarie Mantese
Raymond McCauley
Personal genome appsCrowd-sourced clinical trials
Marat Nepomnyashy
Ted Odet
Roland Parnaso
Thomas Pickard
William Reinhardt
Greg Smith
Aaron Vollrath
Lawrence S. Wong
International collaborations:
JST and Rikengenesis
Takashi Kido
Minae Kawashima
Jin Yamanaka
University Hospitals of Geneva
Louis Nahum
Armin Schnider