perhitungan dapar niar
DESCRIPTION
daparTRANSCRIPT
Perhitungan Perhitungan DaparJenis dapar/kombinasi:Dapar fosfat/ sodium fosfat dibasic, monobasicTarget pH:7,4 pH stabil heparin sodium 5.5-8.0Kapsitas dapar:4.5 8.5 = 0.01Diketahui : pKa1=2.15BM Monosodium Fosfat= 138pKa2=7.20BM disodium Fosfat= 142pKa3=12.38 pKa= - Log [Ka]7.20= - Log [Ka]Ka= 10-32 Ka= 6.3 x 10-8 pH= - Log [H+]7.4= - Log [H+][H+]= 3.9 x 10-8 = 2,303 x C0.1= 2,303 x C0.1= 2,303 x C= 2,303 x C x 0.23620.5439 C=0.1C= C= 0.184 moL/L pH= pKa + log 7.4= 7.2 + log log = 7.2- 7.4log = 0.2 = 0.631[Garam]= 0.631 [Asam] C= [Garam]+ [Asam]0.184= 0.631[Asam]+ [Asam]0.184= 1.631 [Asam][Asam]= = 0.113 [Garam]= 0.631 [Asam]= 0.631 [0.113]= 0.071 Massa disodium Fosfat=BM x [Garam] x V=142 x 0.071x 0.1=1.0082 % Massa monosodium Fosfat=BM x [Asam] x V=138 x 0.113x 0.1=1.5594 % Perhitungan TonisitasBahan%LisoBMEMassa NaCl (%)
Heparin Sodium3.36--0.080.2688
Disodium Fosfat1.0082-1420.420,423
Sodium Fosfat1.5594-1380.290,452
Jumlah NaCl dalam sediaan = 1,1438 (hipertonis) Perhitungan BahanHeparin Sodium=Metil Paraben=Propil Paraben= Disodium Fosfat = sodium Fosfat =