pediatrik onkoloji yayınları
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Pediatrik Onkoloji YayınlarıTRANSCRIPT
Prof. Dr. Alp ÖzkanUzm. Dr. Bahar Genç
TÜRK PEDİATRİK ONKOLOJİ YAYIN GÖSTERGELERİ
1953-2011
TÜR
K PED
İATRİK
ON
KO
LOJİ
YAYIN
GÖ
STERG
ELERİ 1953-2011
Prof. Dr. Alp Ö
zkanUzm
. Dr. Bahar Genç
978-975-420-974-7
TÜRK PEDİATRİK ONKOLOJİ YAYIN GÖSTERGELERİ
1953-2011
Prof. Dr. Alp Özkan
Uzm. Dr. Bahar Genç
NOBEL TIP KİTABEVLERİ
© 2013 Nobel Tıp Kitabevleri Ltd. Şti.
TÜRK PEDİATRİK ONKOLOJİ YAYIN GÖSTERGELERİ 1953-2011
Prof. Dr. Alp ÖzkanUzm. Dr. Bahar Genç
ISBN: 978-975-420-974-7
Bu kitabın, 5846 ve 2936 sayılı Fikir ve Sanat Eserleri Yasası Hükümleri gereğince yazarın yazılı izni olmadan bir bölümünden alıntı yapılamaz; fotokopi yöntemiyle çoğaltılamaz; resim, şekil, şema, grafik, vb.’ler kopya edilemez. Her hakkı Nobel Tıp Kitabevleri Ltd Şti’ne aittir.
Resimler: Balaban
Düzenleme: NobelTıpKitabevleri-HakkıÇakır
Kapak: AlpÖzkan,HakkıÇakır
Baskı/Cilt: NobelMatbaacılık,Hadımköy-İSTANBUL
İçindekiler
Önsöz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . VIIKitabınMetodolojisi . . . . . . . . . . . . . . . . . . . . . . IX
BÖLÜM 1 GENEL TOPLAMLAR VE KARŞILAŞTIRMALAR . .1
1 TürkPediatrikOnkolojiYayınGöstergeleri (1953-2011):GenelToplamlarve Karşılaştırmalar . . . . . . . . . . . . . . . . . . . . .3
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER . . . . . . . . . . . . . . .17
2 Lenfoma . . . . . . . . . . . . . . . . . . . . . . . .19 a .HodgkinLenfoma . . . . . . . . . . . . . . . . .21 b .Non-HodgkinLenfoma . . . . . . . . . . . . . .23 3 MerkeziSinirSistemiTümörleri . . . . . . . . . . .69 4 Nöroblastom . . . . . . . . . . . . . . . . . . . . . 139 5 WilmsveDiğerBöbrekTümörleri . . . . . . . . . 159 6 YumuşakDokuSarkomları . . . . . . . . . . . . . 173 a .Rabdomiyosarkom . . . . . . . . . . . . . . . . 173 b .Non-RabdoidYumuşakDokuSarkomları . . . 175 7 Osteosarkom . . . . . . . . . . . . . . . . . . . . . 173 8 EwingSarkomu . . . . . . . . . . . . . . . . . . . 207 9 Retinoblastom . . . . . . . . . . . . . . . . . . . . 21710 NazofarenksKanseri . . . . . . . . . . . . . . . . . 22911 GermHücreliTümörler . . . . . . . . . . . . . . . 24112 KaraciğerTümörleri . . . . . . . . . . . . . . . . . 26313 Histiyositozlar . . . . . . . . . . . . . . . . . . . . 27514 NadirTümörler . . . . . . . . . . . . . . . . . . . 303
BÖLÜM 3 HEMATOLOJİK MALİGNİTELER . . . . . . . . . . . 335
15 Lösemiler . . . . . . . . . . . . . . . . . . . . . . . 337 a .AkutLenfoblastikLösemiler . . . . . . . . . . . 339 b .AkutMiyeloidLösemiler . . . . . . . . . . . . . 388 c .KronikLösemiler . . . . . . . . . . . . . . . . . 410 d .BifenotipikLösemiler . . . . . . . . . . . . . . . 415 e .KarışıkHastaGruplarıylaYapılanYayınlar . . . 41616 MiyelodisplastikveMiyeloproliferatif Sendromlar . . . . . . . . . . . . . . . . . . . . . . 435
BÖLÜM 4 DESTEK TEDAVİLER . . . . . . . . . . . . . . . . . . . 445
17 DestekTedaviYayınları . . . . . . . . . . . . . . . 447
a .İnfeksiyon/FebrilNötropeni . . . . . . . . . . . 451 b .Aciller . . . . . . . . . . . . . . . . . . . . . . . 485 c .DiğerDestekTedaviYayınları . . . . . . . . . . 506
BÖLÜM 5 GEÇ ETKİLER . . . . . . . . . . . . . . . . . . . . . . . . 567
18 GeçEtkiler . . . . . . . . . . . . . . . . . . . . . . 569 a .KardiyakEtkiler . . . . . . . . . . . . . . . . . . 571 b .EndokrinEtkiler . . . . . . . . . . . . . . . . . 581 c .İkincilKanserler . . . . . . . . . . . . . . . . . . 585 d .DiğerGeçEtkiYayınları . . . . . . . . . . . . . 590
BÖLÜM 6 BENİGN TÜMÖRLER . . . . . . . . . . . . . . . . . . . 601
19 BenignTümörler . . . . . . . . . . . . . . . . . . . 603 a .Adenomlar . . . . . . . . . . . . . . . . . . . . . 604 b .Hamartom . . . . . . . . . . . . . . . . . . . . .607 c .İnflamatuvarPsödotümör . . . . . . . . . . . . 609 d .KemikLezyonları . . . . . . . . . . . . . . . . . 612 e .LipomatözLezyonlar . . . . . . . . . . . . . . . 615 f .Mastositoz . . . . . . . . . . . . . . . . . . . . . 621 g .MesenkimalTümörler . . . . . . . . . . . . . . 622 h .NörojenikTümörler . . . . . . . . . . . . . . . 629 ı .VaskülerLezyonlar . . . . . . . . . . . . . . . . 633 j .DiğerMaligniteyiTaklitEdenDurumlar . . . . 643
BÖLÜM 7 TRANSPLANTASYON . . . . . . . . . . . . . . . . . . . 657
20 Transplantasyon . . . . . . . . . . . . . . . . . . . 659
BÖLÜM 8 DİĞER YAYINLAR . . . . . . . . . . . . . . . . . . . . .685
21 DiğerYayınlar . . . . . . . . . . . . . . . . . . . . 687
BÖLÜM 9 TÜRK PEDİATRİK ONKOLOJİ YAYINLARININ YER ALDIĞI DERGİLER . . . . . . . . . . . . . . . . . 717
22 TürkPediatrikOnkolojiYayınlarının YerAldığıDergiler . . . . . . . . . . . . . . . . . . 719
V
Önsöz
Bukitapbirbellektazelemegereksinimindendoğdu .‘İnsan belleğiyle var olan yaratıktır ve bu nedenle, belleğini yitirmiş in-sanın ilerlemesi mümkün olamıyor. Bellek yıkımı çöküşün nedenlerinden biridir.’Akademikdeğeryargılarınınhızladeğiştiğibirdönemdeyiz .Bukitaptayeralanherçalışmadeğeryargılarıdeğişsebiledeğerindenbirşeykaybetmeyecektir .Herdeğerinyoğunbiremekiçerdiğinibilimdünyasıiçindekiinsanlarçokiyibilirler .
Kitabınsatıraralarınıokumakveyorumlamakokuyucuyadüşmektedir .Bensadeceaktardım .Sizdenaldığımısizesundum .BukitaplabiryerdealtmışyıllıkTürkpediatrikonkolojibilimselyayıntarihinisunmayaçalıştım .Bazıarkadaşlarımızıntekbaş-larınabirüniversiteolduklarınıgördüm .Onlarveülkembilimiadınaçoksevindim .İhtiyacıkarşılamakistedim,önemliolanınbuolduğunainanıyorum .
TürkresimsanatınınbüyükustasıBalaban’avedesenlerinisağlayanBilim-SanatGalerisiyöneticisisevgiliNevzatMetin’esonsuzteşekkürler .
KitabıntasarımıvebasımıiçinNobelTıpKitabevleriyöneticisiErsalBingölveHakkıÇakır’ateşekkürediyorum .
SonsözBahar’a,hızırgibiyetişti .Oolmasaydıbukitabıtamamlayamazdım .Sevgilerimiyazıyorum .
Alp ÖzkanCerrahpaşa-2009
ASM-Gebze-2013
VII
Kitabın Metodolojisi
Buçalışmadaülkemizdenüretilmişçocuklukçağıkanserlerivekanseritaklitedenselimdurumlaraaitve31Aralık2011tarihinekadarbasılmışyayınlarınbirdökümüyapılmıştır . Yayın dökümü için ana kaynak olarak NCBI (NationalCenter for Bıotechnology Information)’nin indeksi Pubmedkullanılmıştır .Pubmed’de indekslenmeyenancakScienceCi-tation Index’de yer alan yayinlar da ayrica yayın dökümüneeklenmiştir .SCI-E’yedahilolanTürkdergileri, indeksedahilolduktan sonraki tarihlerden itibaren taranmışlardır . Taramaüçgrupbilimdalıvehastalıkhistopatolojikkodlarınıiçermiş-tir .PediatrikOnkoloji,PediatrikHematolojivediğerbranşlar(beyin cerrahisi, çocuk cerrahisi vb) taramadaki yazar kay-naklarını oluşturmuştur . Pediatrik Onkoloji uzmanları listesiTPOG(TürkPediatrikOnkolojiGrubu),PediatrikhematolojiuzmanlarılistesiTPHD(TürkPediatrikHematolojiDerneği),Pediatrikcerrahiuzman listesiTürkÇocukCerrahisiDerne-ğiyoluylasağlanmıştır .İsimlerkişilerinçalıştığıkurumlaraaitinternet adreslerinden doğrulanmıştır ve eksik isimler eklen-miştir .Ayrıcakişilere ait yayınlardakidiğeryazarlarla çaprazkarşılaştırmayapılarakkontroledilmiştir .EldeedilenisimlereaitçocukonkolojisineaityayınlarPubmedaracılığıyla taran-mış, selimhematolojiyeait yadaayırıcı tanısındakanseryeralmayanyayınlartaramadışıbırakılmıştır .Biryayındakitara-nankişidışındakidiğeryazarlarındayayınlarıayrıcataranmışveçocukonkolojisiileilgiliolmasıdurumundadökümedahiledilmiştir . Pediatrik Onkoloji ve daha çok pediatri polikliniğinebaşvuran malign ya da benign kitlesi olan hastaların da ço-cuk onkolojisi yayınları içinde yer almasının uygun olacağıdüşünülmüştür .Bunedenlekitleylebaşvuranveayırcıtanıdamalignitedüşünülenolgularileilgiliyayınlardadahiledildi .Nazofarenks karsinomu gibi daha çok radyasyon onkolojisitarafındanizlenenyadadüşükdereceligliomlargibioperas-yon sonrası nöroşirurji kliniklerinden hastaların pediatrikonkolojikliniklerindegörülmeyebileceiğidüşünülerekhisto-patolojikkodlarlataramayapıldı .Aranankodlar:
- Leukemia- Lymphoma- Braintumor- Spinetumor- Neuroblastoma- Wilms’tumor- Rhabdomyosarcoma
- Softtissuesarcoma- Ostesarcoma/bonetumor- Ewingsarcoma- Retinoblastoma- Nasopharynxcarcinoma- Histiocytosis- Germcelltumor- Livertumor
İsimlerdeki yazım hatalarından dolayı zaman zamanPubmed’in yetersiz kaldığı görüldü . Bu durum çapraz yazarkarşılaştırmasıyapılarakgiderilmeyeçalışıldı . Yurtdışıkaynaklıyadamultisentrikyayınlardayazarsı-ralamasında ilk isimolunmamasıdurumundakişininyayınıgözükmeyeceğiiçin,okişiilkyazarolarakgösterildi . Türkiye’debirkurumdagörevyapmaktaikenyurtdışındaeğitimamaçlıbulunulduğusıradayapılanyayınlarokurumunisimiyle kaydedildi, Türkiye bağlantısı olmadan yurtdışındabulunulduğusıradayapılançalışmalar iseoülkenin ismi ilekaydedildi .Kurumlarınsıralamasıyapılırkenilkisimyazarınbağlıolduğukurumyayınınkurumuolarakkabuledildi . Herkonubaşlığı içinokonudaençokyayınıve ençokilkisimyayınıolankişivekurumlarbelirlenmeyeçalışıldı .Buistatistiğiyapmamızdakiamaçşöyleaçıklanabilir .Olanaklarıkısıtlımerkezlerdetedavisimümkünolmayanhastalıklardayada üst merkez konsültasyonu gerektiğinde o konudaki refe-ransmerkezvekişileribelirlemek . Yayınsayılarınagöreilk10listeleriyapılırken,10 .sıradakiyayınsayısınınbirdenfazlakişiyadakurumtarafındanpay-laşılmasıdurumunda, tümkurumvekişiler temsiledilmeyeçalışıldı .Yeterlidökümyapacaksayıdayayınolmamasıduru-mundaiselistelerdahaazkişivekurumlasınırlandırıldı . TümbilgilerThomsonISIWebofScience(WoS)kayna-ğındandoğrulanmıştır .PubmedSCI-E’yedahilolmayanya-zılarıda içermektedir,bizimdökümümüzdebuşekildeolanyayınsayısı61olarakbulunmuştur .Bukitapteyeralan2410yayıniçindeihmaledilebilirbirdeğerolduğundan,61yayınayrıtutulmamıştır . Kitabınanaamacıistatistikdeğildir,ülkemizdepediatriktümörlerintedavisinderolalankişilereelaltındakaynakol-ması,referansolarakkendiyayınlarımızındahafazlakullana-lıbilmesivegençneslintanımaşansıyakalayamayacağıustala-rıneserlerineulaşımınsağlanmasıdır .
IX
3
1953-2011yıllarıarasında toplam2410yayın tespitedilmiştir .Yazılarda toplam4152yazargörevalmıştır .Yazıbaşınayazarortalaması4 .9yazardır .Buyayınlarda158kurumgörevalmıştır .
TABLO 1. Birinci isim ilk 10 yazar
ADI, SOYADI KURUM DERLEMEEDİTÖRE MEKTUP
ÖZGÜN ARAŞTIRMA
SERİ ÇALIŞMA
VAKA TAKDİMİ TOPLAM
Gönül Hiçsönmez Hacettepe Üniversitesi 3 14 5 5 17 44
Şinasi Özsoylu Hacettepe Üniversitesi 0 29 2 0 3 34
Sevgi Yetgin Hacettepe Üniversitesi 1 2 10 1 13 27
Ayhan Çavdar Ankara Üniversitesi 0 4 15 5 1 25
Canan Akyüz Hacettepe Üniversitesi 0 1 3 11 9 24
Nilgün Kurucu Yarış Karadeniz Teknik Üniversitesi 1 3 5 2 12 23
Yavuz Köksal Selçuk Üniversitesi 0 0 2 1 19 22
Ali Varan Hacettepe Üniversitesi 3 0 2 11 6 22
Funda Çorapçıoğlu Kocaeli Üniversitesi 0 2 5 1 13 21
Rejin Kebudi İstanbul Üniversitesi 1 0 5 3 10 19
1 Türk Pediatrik Onkoloji Yayın Göstergeleri (1953-2011): Genel Toplamlar ve Karşılaştırmalar
BÖLÜM 1 TÜRK PEDİATRİK ONKOLOJİ YAYIN GÖSTERGELERİ (1953-2011): GENEL TOPLAMLAR VE KARŞILAŞTIRMALAR4
TABLO 2. Birinci isim ilk 10 pediatrik onkolog
ADI, SOYADI KURUM DERLEMEEDİTÖRE MEKTUP
ÖZGÜN ARAŞTIRMA
SERİ ÇALIŞMA
VAKA TAKDİMİ TOPLAM
Ayhan Çavdar Ankara Üniversitesi 0 4 15 5 1 25
Canan Akyüz Hacettepe Üniversitesi 0 1 3 11 9 24
Nilgün Kurucu Yarış Karadeniz Teknik Üniversitesi 1 3 5 2 12 23
Yavuz Köksal Selçuk Üniversitesi 0 0 2 1 19 22
Ali Varan Hacettepe Üniversitesi 3 0 2 11 6 22
Funda Çorapçıoğlu Kocaeli Üniversitesi 0 2 5 1 13 21
Rejin Kebudi İstanbul Üniversitesi 1 0 5 3 10 19
Serhan Küpeli Çukurova Üniversitesi 0 3 3 2 11 19
Tezer Kutluk Hacettepe Üniversitesi 0 5 6 4 4 19
Münevver Büyükpamukçu Hacettepe Üniversitesi
0 0 2 13 1 16
TABLO 3. Yazar sırası gözetilmeksizin ilk on yazar
ADI, SOYADI KURUM DERLEMEEDİTÖRE MEKTUP
ÖZGÜN ARAŞTIRMA
SERİ CALİSMA
VAKA TAKDİMİ TOPLAM
Münevver Büyükpamukçu Hacettepe Üniversitesi 1 14 37 57 94 203
Canan Akyüz Hacettepe Üniversitesi 0 6 27 48 48 129
Tezer Kutluk Hacettepe Üniversitesi 0 7 26 49 29 111
Ali Varan Hacettepe Üniversitesi 3 6 17 36 36 98
Murat Tuncer Hacettepe Üniversitesi 4 19 35 15 24 97
Gönül Hiçsönmez Hacettepe Üniversitesi 3 21 17 9 34 84
Mualla Çetin Hacettepe Üniversitesi 0 3 32 16 31 82
Bilgehan Yalçın Hacettepe Üniversitesi 1 3 12 19 34 69
Sevgi Yetgin Hacettepe Üniversitesi 1 5 25 14 24 69
Aytemiz Gürgey Hacettepe Üniversitesi 0 7 24 13 19 63
TABLO 4. Yazar sırası gözetilmeksizin ilk on pediatrik onkolog
ADI, SOYADI KURUM DERLEMEEDİTÖRE MEKTUP
ÖZGÜN ARAŞTIRMA
SERİ CALİSMA
VAKA TAKDİMİ TOPLAM
Münevver Büyükpamukçu Hacettepe Üniversitesi 1 14 37 57 94 203
Canan Akyüz Hacettepe Üniversitesi 0 6 27 48 48 129
Tezer Kutluk Hacettepe Üniversitesi 0 7 26 49 29 111
Ali Varan Hacettepe Üniversitesi 3 6 17 36 36 98
Bilgehan Yalçın Hacettepe Üniversitesi 1 3 12 19 34 69
Nur Olgun Dokuz Eylül Üniversitesi 0 2 20 6 24 52
Aynur Oğuz Gazi Üniversitesi 0 3 20 9 18 50
Faik Sarıalioğlu Başkent Üniversitesi 0 4 9 11 24 48
Rejin Kebudi İstanbul Üniversitesi 2 1 14 12 18 47
Ceyda Karadeniz Gazi Üniversitesi 0 3 19 8 17 47
5KONU 1 Türk Pediatrik Onkoloji Yayın Göstergeleri (1953-2011): Genel Toplamlar ve Karşılaştırmalar
TABLO 5. Özgün araştırma ve seri çalışma toplamına göre ilk isim on yazar (8 yayını olan 3 yazar eklenmiştir)
ADI, SOYADI KURUM ÖZGÜN ARAŞTIRMA SERİ CALİSMA TOPLAMAyhan Çavdar Ankara Üniversitesi 15 5 20
Münevver Büyükpamukçu Hacettepe Üniversitesi 2 13 15
Canan Akyüz Hacettepe Üniversitesi 3 11 14
Ali Varan Hacettepe Üniversitesi 2 11 13
Su Gülsün Berrak Marmara Üniversitesi 9 2 11
Sevgi Yetgin Hacettepe Üniversitesi 10 1 11
Gönül Hiçsönmez Hacettepe Üniversitesi 5 5 10
Tezer Kutluk Hacettepe Üniversitesi 6 4 10
Aynur Oğuz Gazi Üniversitesi 6 3 9
İnci Ayan İstanbul Üniversitesi 4 4 8
Aytemiz Gürgey Hacettepe Üniversitesi 4 4 8
Rejin Kebudi İstanbul Üniversitesi 3 5 8
TABLO 6. Özgün araştırma ve seri çalışma toplamına göre ilk isim on pediatrik onkolog
ADI, SOYADI KURUM ÖZGÜN ARAŞTIRMA SERİ CALİSMA TOPLAM
Ayhan Çavdar Ankara Üniversitesi 15 5 20
Münevver Büyükpamukçu Hacettepe Üniversitesi 2 13 15
Canan Akyüz Hacettepe Üniversitesi 3 11 14
Ali Varan Hacettepe Üniversitesi 2 11 13
Su Gülsün Berrak Marmara Üniversitesi 9 2 11
Tezer Kutluk Hacettepe Üniversitesi 6 4 10
Aynur Oğuz Gazi Üniversitesi 6 3 9
İnci Ayan İstanbul Üniversitesi 4 4 8
Rejin Kebudi İstanbul Üniversitesi 5 3 8
Nilgün Kurucu Yarış Karadeniz Teknik Üniversitesi 5 2 7
TABLO 7. Yazar sırası gözetilmeksizin özgün araştırma ve seri çalışma toplamına göre ilk on yazar
YAZAR ADI KURUM ADIDERLEME/SERİ ÇALIŞMA/ÖZGÜN ARAŞTIRMA
TOPLAMI
Münevver Büyükpamukçu Hacettepe Üniversitesi 95
Canan Akyüz Hacettepe Üniversitesi 75
Tezer Kutluk Hacettepe Üniversitesi 75
Ali Varan Hacettepe Üniversitesi 56
Murat Tuncer Hacettepe Üniversitesi 54
Mualla Çetin Hacettepe Üniversitesi 48
Sevgi Yetgin Hacettepe Üniversitesi 40
Aytemiz Gürgey Hacettepe Üniversitesi 37
İnci Ayan İstanbul Üniversitesi 32
Bilgehan Yalçın Hacettepe Üniversitesi 32
BÖLÜM 1 TÜRK PEDİATRİK ONKOLOJİ YAYIN GÖSTERGELERİ (1953-2011): GENEL TOPLAMLAR VE KARŞILAŞTIRMALAR6
TABLO 8. Yazar sırası gözetilmeksizin özgün araştırma ve seri çalışma toplamına göre ilk on pediatrik onkolog
YAZAR ADI KURUM ADIDERLEME/SERİ ÇALIŞMA/ÖZGÜN ARAŞTIRMA
TOPLAMI
Münevver Büyükpamukçu Hacettepe Üniversitesi 95
Canan Akyüz Hacettepe Üniversitesi 75
Tezer Kutluk Hacettepe Üniversitesi 75
Ali Varan Hacettepe Üniversitesi 56
İnci Ayan İstanbul Üniversitesi 32
Bilgehan Yalçın Hacettepe Üniversitesi 32
Ayhan Çavdar Ankara Üniversitesi 29
Aynur Oğuz Gazi Üniversitesi 29
Rejin Kebudi İstanbul Üniversitesi 28
Ceyda Karadeniz Gazi Üniversitesi 27
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ŞEKİL 5. En çok yayını olan ilk 10 kurumun yayın sayıları ve sitasyon ortalamaları karşılaştırması. (Yayın başına düşen ortanca sitasyon sayısı tüm kurumlar için 2 olarak bulunmuştur.)
ŞEKİL 6. Kurumların yayın kaynaklarına göre yayın dağılımları.
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19
1953-2011yıllarıarasındatoplam220adetLenfoma/Retiküloendotelyalsistemkonuluyayıntespitedilmiştir .Lenfomaaltgrup-larınabakıldığında69Hodgkinlenfoma,137Hodgkindışılenfoma,14herikitiptelenfomayayınıbulunmuştur .
Lenfomayayınlarının73adediderleme,özgünaraştırmaveseriçalışmaşeklindeolup,147adedieditöremektupveolgusunum-larındanoluşmaktadır .
TABLO 1. Tüm lenfoma yayınları için en çok birinci isim yayını olan ilk 10 yazar
YAZAR ADIİLK İSİM YAYIN SAYISI (TÜM LENFOMA GRUBU)
Ayhan Çavdar, Tezer Kutluk 9
Yavuz Köksal 8
Münevver Büyükpamukçu 7
Ceyda Karadeniz 6
Serhan Küpeli, Nilgün Yarış Kurucu, Aynur Oğuz 5
Funda Çorapçıoğlu, Sevgi Gözdaşoğlu, İnci İlhan 4
TABLO 2. Yazar sırası gözetilmeksizin tüm lenfoma yayınları için en çok yayını olan ilk 10 yazar
YAZAR ADIYAYIN SAYISI
(TÜM LENFOMA GRUBU)Münevver Büyükpamukçu 53
Canan Akyüz 34
Tezer Kutluk 28
Ali Varan 20
Bilgehan Yalçın 17
Ceyda Karadeniz 16
Aynur Oğuz 16
Ayhan Çavdar 14
Sevgi Gözdaşoğlu 14
Faik Sarıalioğlu 14
2 Lenfoma
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER20
TABLO 3. Tüm lenfoma yayınlarına göre en çok yayını olan ilk 10 kurum
LENFOMA YAYINLARINDA İLK 10 KURUM YAYIN SAYISIHacettepe Üniversitesi 80
Gazi Üniversitesi 24
Ankara Üniversitesi 19
İstanbul Üniversitesi 16
Dokuz Eylül Üniversitesi 8
Dr. Sami Ulus EAH 7
Selcuk Üniversitesi 6
Cukurova Üniversitesi 5
Kocaeli Üniversitesi 5
Karadeniz Teknik Üniversitesi 5
TABLO 4. Tüm lenfoma yayınları içinde en çok sitasyon alan ilk 10 yayın
YAZAR ADI KURUM YIL ÇALIŞMA ADI DERGİ ADI ÇALIŞMA TİPİ
SİTASYON SAYISI
Kapucu LO Hacettepe Üni. 1997 Evaluation of therapy response in children with untreated malignant lymphomas using technetium-99m-sestamibi
J Nucl Med Özgün araştırma
37
Kutluk T Hacettepe Üni. 1997 Childhood cancer and hypercalcemia: report of a case treated with pamidronate
J Pediatr Vaka takdimi
35
Cavdar AO Ankara Üni. 1994 Burkitt’s lymphoma in Turkish children: clinical, viral [EBV] and molecular studies
Leuk Lymphoma
Özgün araştırma
21
Cavdar AO Ankara Üni. 1993 Burkitt’s lymphoma between African and American types in Turkish children: clinical, viral (EBV), and molecular studies
Med Pediatr Oncol
Özgün araştırma
21
Ceyhan M Hacettepe Üni. 1994 Lymphoma with bilateral cavernous sinus involvement in early childhood
Pediatr Neurol Vaka takdimi
18
Buyukpamukcu M
Hacettepe Üni. 1999 Hodgkin’s disease in Turkish children: clinical characteristics and treatment results of 210 patients
Pediatr Hematol Oncol
Seri çalışma
16
Alpaslan G Gazi Üni 1999 Disturbances in oral and dental structures in patients with pediatric lymphoma after chemotherapy: a preliminary report
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
Özgün araştırma
15
Ertem M Ankara Üni 2000 Immune thrombocytopenia and hemolytic anemia as a presenting manifestation of Hodgkin disease
Pediatr Hematol Oncol
Vaka takdimi
15
Kutluk T Hacettepe Üni 1999 Serum CA 125 levels in children with non-Hodgkin’s lymphoma
Pediatr Hematol Oncol
Özgün araştırma
14
Kebudi R Istanbul Üni 1997 Hypertrophic osteoarthropathy and intrathoracic Hodgkin disease of childhood
Med Pediatr Oncol
Vaka takdimi
14
21KONU 2 Lenfoma
TABLO 5. Hodgkin lenfoma yayınları için en çok birinci isim yayını olan ilk 10 yazarDiğer 38 yazarın birer yayını vardır.
YAZAR ADI İLK İSİM YAYIN SAYISIAyhan Çavdar 6
Münevver Büyükpamukçu, Serhan Küpeli 4
Semha Berberoğlu, Suna Emir, Sevgi Gözdaşoğlu, İnci İlhan, Ceyda Karadeniz, Rejin Kebudi, Asuman Müftüoğlu, Aynur Oğuz
2
TABLO 6. Hodgkin lenfoma konusunda yazar sırası gözetilmeksizin en çok yayını olan ilk 10 yazar
YAZAR ADI HODGKİN LENFOMA YAYIN SAYISI Münevver Büyükpamukçu 22
Canan Akyüz 13
Tezer Kutluk 12
Emel Babacan 9
Ayhan Cavdar 9
Sevgi Gozdasoglu 9
Ulya Ertem 7
Ali Varan 7
Ayten Arcasoy 6
Bilgehan Yalcin 6
TABLO 7. Hodgkin lenfoma yayınlarına göre en çok yayını olan ilk 10 kurumDiğer 11 kurumun birer yayını vardır.
KURUM ADI HODGKIN LENFOMA YAYIN SAYISIHacettepe Üniversitesi 29
Ankara Üniversitesi 12
İstanbul Üniversitesi 8
Gazi Üniversitesi 4
Dr. Sami Ulus EAH 3
Kocaeli Üniversitesi 2
A. HODGKIN LENFOMA
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER22
TABLO 8. Yayın sitasyon sayısına göre ilk 10 yayın
YAZAR ADI KURUM YIL ÇALIŞMA ADI DERGİ ADI ÇALIŞMA TİPİ
SİTASYON SAYISI
Büyükpamukçu MHacettepe Üni.
1999Hodgkin’s disease in Turkish children: clinical characteristics and treatment results of 210 patients
Pediatr Hematol Oncol
Seri çalışma
16
Ertem MAnkara Üni.
2000Immune thrombocytopenia and hemolytic anemia as a presenting manifestation of Hodgkin disease
Pediatr Hematol Oncol
Vaka takdimi
15
Kebudi Rİstanbul Üni.
1997Hypertrophic osteoarthropathy and intrathoracic Hodgkin disease of childhood
Med Pediatr Oncol
Vaka takdimi 14
Çavdar AOAnkara Üni.
1987Zinc and anergy in pediatric Hodgkin’s disease in Turkey
CancerÖzgün araştırma 12
Yalçın BHacettepe Üni.
2002Hodgkin’s disease and ataxia telangiectasia with pulmonary cavities
Pediatr Pulmonol
Vaka takdimi 11
Varan AHacettepe Üni.
1999Prognostic importance of magnetic resonance imaging in bone marrow involvement of Hodgkin disease
Med Pediatr Oncol
Seri çalışma
11
Oğuz A Gazi Üni. 2005Prognostic factors and treatment outcome in childhood Hodgkin disease
Pediatr Blood Cancer
Seri çalışma 11
Topçu MHacettepe Üni.
1992Paraneoplastic syndrome manifesting as chronic cerebellar ataxia in a child with Hodgkin disease
J PediatrVaka takdimi
10
Akyüz CHacettepe Üni.
2005Intracranial involvement in Hodgkin’s disease
Pediatr Hematol Oncol
Vaka takdimi 9
Karadeniz C Gazi Üni. 2001Hypertrophic osteoarthropathy and childhood Hodgkin disease
Pediatr Hematol Oncol
Editöre mektup 9
Çavdar AOAnkara Üni.
1980 Zinc deficiency in Hodgkin’s disease Eur J CancerÖzgün araştırma 9
23KONU 2 Lenfoma
TABLO 9. NonHodgkin lenfoma yayınları için en çok birinci isim yayını olan ilk 10 yazarDiğer 87 yazarın birer yayını vardır.
YAZAR ADI İLK İSİM YAYIN SAYISITezer Kutluk 8
Yavuz Köksal 6
Ceyda Karadeniz 4
Nilgün Yarış Kurucu 4
Münevver Büyükpamukçu 3
Funda Çorapçıoğlu 3
Sinan Akbayram, Safiye Aktaş, Canan Akyüz,Su Berrak, Perran Boran, Ayhan Çavdar, Çağlar Çıtak, Sevgi Gözdaşoğlu, Aynur Oğuz, Visal Okur
2
TABLO 10. Non-Hodgkin lenfoma konusundan yazar sırası gözetilmeksizin en çok yayını olan ilk 10 yazar
YAZAR ADI NON-HODGKİN LENFOMA YAYIN SAYISIMünevver Büyükpamukçu 28
Canan Akyüz 20
Tezer Kutluk 16
Ali Varan 11
Bilgehan Yalcin 11
Ceyda Karadeniz 8
Yavuz Köksal 8
Aynur Oguz 8
Faik Sarialioglu 8
Ömer Uluoğlu 7
TABLO 11. Non-Hogkin lenfoma yayınlarına göre en çok yayını olan ilk 10 kurum
KURUM NHL YAYIN SAYISIHacettepe Üniversitesi 48
Gazi Üniversitesi 16
İstanbul Üniversitesi 7
Dokuz Eylül Üniversitesi 7
Ankara Üniversitesi 6
Çukurova Üniversitesi 5
Selçuk Üniversitesi 5
GATA 4
Karadeniz Teknik Üniversitesi 4
Akdeniz, Dicle, Erciyes, Kocaeli ve Van Yüzüncü Yıl Üniversiteleri
3
B. NON-HODGKIN LENFOMA
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER24
TABLO 12. Yayın sitasyon sayısına göre ilk 10 yayınYAZAR ADI KURUM YIL ÇALIŞMA ADI DERGİ ADI ÇALIŞMA
TİPİSİTASYON SAYISI
Kutluk THacettepe Üni.
1997Childhood cancer and hypercalcemia: report of a case treated with pamidronate
J PediatrVaka takdimi
35
Çavdar AOAnkara Üni.
1994Burkitt’s lymphoma in Turkish children: clinical, viral [EBV] and molecular studies
Leuk Lymphoma
Özgün araştırma
21
Çavdar AOAnkara Üni.
1993Burkitt’s lymphoma between African and American types in Turkish children: clinical, viral (EBV), and molecular studies
Med Pediatr Oncol
Özgün araştırma
21
Ceyhan MHacettepe Üni.
1994Lymphoma with bilateral cavernous sinus involvement in early childhood
Pediatr Neurol
Vaka takdimi
18
Kutluk THacettepe Üni.
1999Serum CA 125 levels in children with non-Hodgkin’s lymphoma
Pediatr Hematol Oncol
Özgün araştırma
14
Taçyıldız NDr. Sami Ulus EAH
1998
Unusually high frequency of a 69-bp deletion within the carboxy terminus of the LMP-1 oncogene of Epstein-Barr virus detected in Burkitt’s lymphoma of Turkish children
LeukemiaÖzgün araştırma
13
Ertem UDr. Sami Ulus EAH
1997Burkitt’s lymphoma in 63 Turkish children diagnosed over a 10 year period
Pediatr Hematol Oncol
Seri çalışma
13
Berrak SGMarmara Üni.
2002Discrepancies in the immunophenotype of lymphoma cells in samples obtained simultaneously from di� erent anatomic sites
Am J Clin Pathol
Özgün araştırma
12
Kutluk THacettepe Üni.
1989 Renal lymphoma. An unusual presentation in a child Turk J PediatrVaka takdimi
11
Kurugoğlu S
İstanbul Üni.
2002Radiological features in paediatric primary gastric MALT lymphoma and association with Helicobacter pylori
Pediatr Radiol
Vaka takdimi
11
25KONU 2 Lenfoma
Department of Pediatric Oncology, Ankara University Fa-culty of Medicine, Ankara, Turkey.
Abstract Fifty-one cases of Hodgkin’s disease in Turkish children
under15yearsofagewereclinicallyanalyzed,and40ca-seswereevaluatedhistopathologicallyaccordingtotheRyeConference classification . Complete clinical, laboratory,and radiologic findings for each patient were examined .Mostpatientswereoflowsocioeconomicclass,andnearlyall were Caucasian . Th e most common presenting clini-calsignwascervical lymphnodeenlargement;hepatosp-lenomegaly was noted in 18 patients . Nearly three timesasmanymalesasfemaleswerefoundamongthepatientswhose diseases were histologically analyzed, and most ofthechildrenwithHodgkin’sdiseasewereinthefirstdecadeoflife .Classificationofthecasesrevealedapredominance(67 .5%)ofthemixedcellularity(MC)type .Of40patientsanalyzed,34haddiseaseinclinicalstageIV,mostlyoftheMCtype .Th edataindicatedacorrelationofthehighinci-denceoftheMCtypeofHodgkin’sdiseasewiththesocioe-conomicandenvironmentalconditionsinTurkey .
7 . EurJCancer .1980Mar;16(3):317-21 . Zinc deficiency in Hodgkin’s disease. CavdarAO,BabacanE,ArcasoyA,ErtenJ,ErtemU . Department of Pediatric Oncology, Ankara University Fa-
culty of Medicine, Ankara, Turkey.8 . ActaHaematol .1980;63(5):286-8 . Lack of correlation between skin reactivity and T
lymphocytes and monocytes in Hodgkin’s disease. MüftüoğluAU,YalçinB . Cerrahpasa Medical Faculty, University of Istanbul, Istan-
bul, Turkey. Abstract
28untreatedpatientswithHodgkin’sdiseasehavebeenstu-diedinrespecttoskinreactivitytopurifiedproteinderiva-tiveanddinitrochlorobenzeneandbloodmonocytesandTlymphocytes .Cutaneousanergyasdefinedbyunresponsi-venesstobothpurifiedproteinderivativeanddinitrochlo-robenzenewasfoundin43%ofpatientsandin7%ofthecontrolgroup .AlthoughtherewasasignificantreductioninE-rosettinglymphocytesinHodgkin’scases,wefoundnodifferencesinthemeannumbersofE-rosettinglymphocy-tesandmonocytesbetweennormergicandanergicpatients .We, therefore, conclude that skin reactivity isnotdirectlycorrelatedwiththetotalnumbersofE-rosettinglymphocy-tesormonocytesinHodgkin’sdisease .
9 . ClinOncol .1982Mar;8(1):73-6 . Achalasia of the oesophagus associated with Hodgkin’s
disease in children. BuyukpamukcuM,BuyukpamukcuN,CevikN .
1 . NEnglJMed .1967Jul20;277(3):126-9 . Passive transfer of tuberculin sensitivity to patients with
Hodgkin’s disease. MüftüoğluAU,BalkuvS . Cerrahpasa Medical Faculty, University of Istanbul, Istan-
bul, Turkey. 2 . AmJDisChild .1968May;115(5):607-10 . Renal amyloidosis and Hodgkin’s disease in a child. SayB,CitipitiogluB,BaykaraE,TinaztepeB . Department of Pediatrics,Hacettepe University, Ankara,
Turkey. 3 . TurkJPediatr .1972Jan;14(1):1-6 . Erythropoietin in children I. Findings in Hodgkin’s Di-
sease. CitipitioğluB . Department of Pediatrics,Hacettepe University, Ankara,
Turkey. 4 . NewIstanbulContribClinSci .1974Jun;11(1):31-8 . High frequency of Hodgkin’s disease in Turkish Children. CavdarAO,GözdaşoğluS,ArcasoyA,TopuzU,BabacanE . Department of Pediatric Oncology, Ankara University Fa-
culty of Medicine, Ankara, Turkey.5 . BollIstSieroterMilan .1977Jul31;56(3):228-34 . Serum zinc levels, lymphocyte counts and functions in
pediatric Hodgkin’s disease. BabacanE,CavdarAO,ArcasoyA . Department of Pediatric Oncology, Ankara University Fa-
culty of Medicine, Ankara, Turkey.Abstract
Serum zinc levels, total lymphocyte counts, cutaneousreactivity to three intradermal antigens and the in vitrolymphoblastictransformationresponsetoPHAwereeva-luatedin24childrenwithHodgkin’sdiseaseand20controlcases .Serumzinclevelwasmeasuredbyatomicabsorpti-onspectrophotometer(PerkinElmerM103)inHodgkin’scasesandfoundtobesignificantlydecreasedinthewholegroupofpatientsandreachedthelowestlevelinLDtypeandtheIVthstageofdisease .Th eoverallresponsetoPHAwasreducedinHodgkin’scases .ItwassignificantlylowinthegroupofLDsubtype .Delayedcutaneoushypersensiti-vityreactionswerealsomarkedlydecreasedintheIVstageandMC,LPsubtypesofHodgkin’spatients .Ourprelimi-naryresultsdisclosedarelationshipbetweenserumzinclevelandthelymphocyteabnormalitiesinHodgkin’sdise-ase .
6 . JNatlCancerInst .1977Mar;58(3):479-81 . Hodgkin’s disease in Turkish children: a clinical and his-
topathologic analysis. CavdarAO,TacoyA,BabacanE,GözdaşoğluS,Arcasoy
A,TopuzU,CinS,ErtenJ .
HODGKIN LENFOMA YAYINLARI
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER26
betweenserumzinclevel,cutaneousanergyandLP .Apos-siblecontributingroleofzincdeficiencyindefectivecellmediated immunity in Hodgkin’s disease was proposed,andadministrationoforalzinc,asanatural immunosti-mulantisconsideredinthislymphoma .
14 .TurkJPediatr .1987Jan-Mar;29(1):61-5 . Giant cell pneumonia associated with Hodgkin’s disease. TinaztepeK,OrmeciAR,TinaztepeB . Division of Pediatric Oncology, Hacettepe Children’s Hospi-
tal, Ankara, Turkey.15 .MedPediatrOncol .1990;18(2):173-5 . Cytotoxic drug-induced fever: a report on procarbazine-
induced hyperpyrexia. AkyolH,SarialioğluF,BüyükpamukçuM,AkyüzC . Division of Pediatric Oncology, Hacettepe Children’s Hospi-
tal, Ankara, Turkey.Abstract
Acaseofhyperpyrexiainducedbyprocarbazineinachildwith Hodgkin’s disease, neurofibromatosis, and pectusexcavatumdeformity ispresented .After thediagnosisofstage IIIS Hodgkin’s disease, combined COPP chemot-herapy was initiated . One week later she presented withhighfever .Afteradiagnosisof infectionwasmade,che-motherapywasstoppedandantibioticsweregiven .Nearlythe same picture recurred three times after reinstitutingchemotherapy .Onthefourthoccasion,thepatienthadtobehospitalizedbecauseofhyperpyrexiaandarrhythmia .Th ere was no obvious reason for fever, and cytotoxic-inducedfeverwasconsidered .Th edrugsweregivenoneatatime .Whenatestdose(10mg)ofprocarbazinewasgiven,shedevelopedahighfeverwithseverenauseaandvomiting .Th ereactionwascontrolledbyantihistaminicsandsteroids .Toourknowledgethis is thesecondreportonhyperpyrexiaduetoprocarbazineadministration .
16 .TurkJPediatr .1991Jul-Sep;33(3):185-90 . Multiple primary malignancy: a report on Langerhans
cell histiocytosis associated with Hodgkin’s disease. KaradenizC,SarialioğluF,GöğüşS,AkyüzC,KüçükaliT,
KutlukT,BüyükpamukçuM . Hacettepe University Institute of Oncology, Ankara.
Abstract Sincemultipleprimarymalignanttumorsarerareinchild-
ren, their presence can be a diagnostic and therapeuticproblem .Inthisreport,wepresentasix-year-oldboywithLangerhans cell histiocytosis and Hodgkin’s disease . Onadmission, the patient had lytic lesions and a periostealreactiononthelefttrochantermajorfromwhichanopenbonemarrowbiopsywasperformed .Th ebiopsy revealedLangerhanscellhistiocytosis .Eightmonthslater,thechildpresentedwithenlargedleftcervicallymphnodesandthebiopsydemonstratedHodgkin’sdisease .Althoughtherewasaneight-monthintervalbetweenthetwohistopathologicaldiagnoses,thediffusepulmonaryparenchymalinfiltrationobservedonthefirstadmission,waslaterconfirmedbyan
Division of Pediatric Oncology, Hacettepe Children’s Hospi-tal, Ankara, Turkey.
10 .ProgClinBiolRes .1983;129:255-60 . Cell-mediated immunity, serum and lymphocyte zinc
levels in Hodgkin’s disease. AcarS,ErseyF,SanalO,BechelI,GebriN .11 .ProgClinBiolRes .1983;129:207-20 . Zinc status and cellular immunity in pediatric Hodgkin’s
disease. CavdarAO,BabacanE,ErtemU,GözdasoğluS,ArcasoyA . Department of Pediatric Oncology, Ankara University Fa-
culty of Medicine, Ankara, Turkey.Abstract
Inthepresentstudyweinvestigatedserum,plasma,RBCand hair zinc concentrations in pediatric Hodgkin’s ca-sesatinitialpresentationandinremission(measuredbyatomic absorption spectrophotometry) . In addition, im-muneparameterssuchastotallymphocytecounts(TLC),E-rosettetest(E-R),lymphocyteproliferative(LP)respon-sestoPHA,andskinteststofourantigensweresimultane-ouslyinvestigatedinsomecases .Althoughallzinclevelswerefoundtobesignificantlylowbeforetreatment,sug-gestingchroniczincdeficiency,serumandplasmazincle-velsreturnedtonormalduringremission .Apositivecor-relationcouldbedetectedonlybetweenserumzinclevelsandlymphocyteblastogenicresponsetoPHA .Hodgkin’spatients with complete anergia also showed significantlylowerserumzinclevelsandLPresponsestoPHAthanthepatientswithoutanergia .
12 .TurkJPediatr .1983Oct-Dec;25(4):267-70 . Histiocytic cell phagocytosis and pancytopenia in a
child with Hodgkin’s disease. YetginS,TelN,BerkelAI . Division of Pediatric Oncology, Hacettepe Children’s Hospi-
tal, Ankara, Turkey.13 .Cancer .1987Jan15;59(2):305-9 . Zinc and anergy in pediatric Hodgkin’s disease in Turkey. CavdarAO,BabacanE,GözdaşoğluS,ErtenJ,CinS,Ar-
casoyA,ErtemU . Department of Pediatric Oncology, Ankara University Fa-
culty of Medicine, Ankara, Turkey.Abstract
Blood (serum, erythrocytes) and hair zinc levels weredetermined in 60 biopsy-proven pediatric Hodgkin’sdisease cases at diagnosis . Cellular immunity also wasassessed through total lymphocyte counts, E-rosette for-mation, lymphoproliferative response (LP), and delayedcutaneoushypersensitivity tests todinitrochlorobenzene,streptokinase-streptodornase, purified protein derivativeandphytohemagglutinin(PHA)insomeofthesepatients .Interestingly, anergic patients unresponsive to four anti-gensshowedsignificantlymoredepressedserumzincle-velsaswellasdecreased lymphoproliferativeresponsetomitogen (PHA) . A positive correlation could be shown
27KONU 2 Lenfoma
between 20-30 Gy . All patients had normal cardiovascu-lar findingsonclinicalexamination .ECGandchest radi-ographywerewithinnormal limits inallpatients .Restingleftventricularejection fractionand fractional shorteningweredecreasedinonlyonepatient(4%),buttherewasnosignificantdifferencebetweenthepatientgroupandacont-rolgroupforleftventricularsystolicfunction(p>0 .05) .Inthepatientgroup,earlydiastolicpeakvelocity,peakvelocityatatrialcontraction, leftventricular isovolumicrelaxationtime,andtherateofdecreaseofflowvelocityinearlydiasto-leweresignificantlydifferentfromthatofthecontrolgroup(p<0 .05) . Inconclusion, the lateeffectsofourtreatmentprotocolforHodgkin’sdiseaseappeartobeminimal .Th eseobservationssupportcombinedmodality,low-doseirradi-ationregimensinchildrenandadolescentsandsuggesttheneedforcarefulcardiacscreeningoftreatedpatients .
20 .JChemother .1995Oct;7(5):463-6 . Late eff ects of chemoradiotherapy in pediatric Hodgkin’s
disease. GözdasogluS,CavdarAO,BabacanE,MengübasK,Yavuz
G,UnalE,PamirA,OcalG,HalukGökçoraI . Department of Pediatrics, University of Ankara, School of
Medicine, Turkey.Abstract
We treated 137 Turkish children with biopsy-provenHodgkin’sdisease,followedupbetweentheyears1964and1989 .Mostpatientsweretreatedandwereinadvancedstagewithhistologicalsubtypeofmixedcellularity(67 .5%) .Ra-diotherapy(Mantleform)and/orMOPP,ABVDandOPPAcombinationchemotherapyregimenswereusedin75 .84%ofpatients .Th efollow-upperiodinthesepatientsrangedfrom5to24years .Th elateeffectsin28patientswhowereevaluated for the late sequelae of chemoradiotherapy arepresented .Sevenoutof28patientsshowedretardedsexualmaturation .Testicularandovarianfunctionswereassessedin11patients,allofwhomshowedelevatedserumFSHle-velsand2azoospermia .Analysisofthyroidfunctionswascarriedoutinpatientsreceivingradiotherapytotheneck .Th ethyroidglandwaspalpablein6patients .Furtheranaly-sisshoweddiffusehyperplasiain5andnodularin1patient .Th enodulewasexcisedandreportedas“nodularcolloidalgoiter” . Two patients had elevated TSH levels . “Swan-likeneck”wasobservedin3patientswhohadreceived40to42Gyradiotherapytotheneck .Cirrhosisduetochroniche-patitisBinfectionwasdiagnosedin2patientsasanunusu-al latecomplication .Th esecondarymalignancyoccurredin only 1 case in the form of “fibrosarcoma” . Th e secondneoplasmwasprobablyradiation-inducedasitoccurredinthefieldofpriorradiotherapy
21 .PostgradMedJ .1995Nov;71(841):689-91 . Anaemia in a child. BerberoğluS . Department of Pediatric Oncology, Oncology Hospital, An-
kara, Turkey.
open-lungbiopsyasHodgkin’sdisease .Th epatientwassaidto have two concurrent lymphoreticular malignancies . Toourknowledge,thisistheyoungestcasereportedwiththisassociationintheEnglishlanguageliterature .
17 .JPediatr .1992Feb;120(2Pt1):275-7 . Paraneoplastic syndrome manifesting as chronic cere-
bellar ataxia in a child with Hodgkin disease. Topcu M, Gucuyener K, Topaloglu H, Renda Y, Akyuz
C,KaleG Department of Pediatric Neurology, Hacettepe University
Children’s Hospital, Ankara, Turkey.Abstract
An 8-year-old boy had nausea and vomiting associatedwith nystagmus, ataxia, and dysarthria of acute onset .Th reeyearslaterhehadamassintheanteriormediasti-num as a result of Hodgkin disease of mixed cellularity .Th isassociationofparaneoplasticcerebellardegenerationwithHodgkindiseasehasbeendescribedinadults .
18 .TurkJPediatr .1995Jul-Sep;37(3):289-92 . Immune thrombocytopenic purpura in a child with
Hodgkin’s disease. BerberoğluS,SarialioğluF,AkyüzC,KutlukT,Büyükpa-
mukçuM . Department of Pediatrics, Hacettepe University Faculty of
Medicine, Ankara.Abstract
Th e occurrence of immune thrombocytopenic purpu-ra (ITP) inHodgkin’sdisease isuncommon .Th is reportdescribesapatientwhodevelopedITPtwicebeforesple-nectomy,andforthethirdtimeseveralyearslater,prece-dinganabdominalrelapseofthedisease .Wesuggestthatpatients with a history of Hodgkin’s disease undergo di-ligentsearches foractivediseasewhenITPisdiagnosed .ITPmaybe theonlymanifestationofactivediseaseandmayprecedehistologicdocumentationofHodgkin’sdise-asebymonthsoryears .
19 .PostgradMedJ .1995Mar;71(833):164-7 . Late cardiac eff ects aft er treatment for childhood
Hodgkin’s disease with chemotherapy and low-dose ra-diotherapy.
IlhanI,SarialiogluF,OzbarlasN,BüyükpamukçuM,Ak-yüzC,KutlukT .
Dr Sami Ulus Childrens’ Hospital, Ankara, Turkey.Abstract
Twenty-four patients under 18 years when treated forHodgkin’s disease (20 male, four female) were examinedno less than five years after the completion of the treat-ment . Th e mean age was 17 years (range 9 .5-25 .0 years)at the time of study . All patients received six courses ofcyclophosphamide-oncovin-procarbazine-prednisolonechemotherapy;inaddition,ninepatientsreceivedlow-doseradiotherapy excluding the mediastinum and eight of 24patients received mediastinal radiotherapy; the dose was
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER28
rare .Only5caseshavebeenassociatedwithHodgkindise-ase,includingthepresentboy .ItisimportantthatpatientswithsymptomsofHOAandanintrathoracicmassbeexa-minedcarefullytoruleoutamalignancy .
24 .PediatrHematolOncol .1997Jul-Aug;14(4):359-66 . Hodgkin’s disease in 82 Turkish children diagnosed
over a 10-year period: epidemiological, clinical, and histopathologic features and prognosis with prolonged chemotherapy.
ErtemU,DuruF,DağdemirA,TaçyildizN,PamirA,Ak-çayözA,UluoğluO,TeziçT .
Department of Pediatric Oncology and Pathology, Dr. Sami Ulus Children’s Hospital, Ankara, Turkey.
Abstract Inthisstudy,82TurkishchildrenwithHodgkin’sdisease
(HD)between1and14yearsofageanddiagnosedovera10-yearperiodwereevaluatedretrospectively .Morethanhalf of the patients (54%) presented with advanced sta-ges of HD . Mixed cellularity (MC) was the most frequ-ent(56 .1%)histopathologictype,whichwasfollowedbynodularsclerosing(NS,18 .3%)infrequency .Noneofthepatientsreceivedradiotherapyasinitialtreatment .In67children theCOPPregimenaloneand in15 theABVDregimenalternatingwithCOPPwerestarted,tobegivenasatotalof12courses .InthepatientswhopresentedwithstageI-IIHDtheoverallsurvival(OAS)rateand5-yeareventfreesurvival(EFS)ratewere92 .3%and77 .8%,res-pectively .Inthepatientswithadvanceddisease(stageIII-IV)OASand5-yearEFSwereestimatedtobe89 .5%and67 .4%,respectively .Noserioustoxicityofchemotherapywasdetectedduringthefollow-up .Inthisgroup,clinical,epidemiologicalandhistopathologicfeaturesofthedise-aseshowedaspecialpatternclosetothetypeIpatternofHD .Regardingthesurvivalrulesandoccurrenceof lowtoxicity in our patients, results of prolonged chemothe-rapyaloneseemtobeencouraginginmostofthechild-renwithHD .However,thefollow-updurationisnotyetsufficienttodeclareaclearconclusionrelatedtothelatecomplications .
25 .RadiatMed .1998Sep-Oct;16(5):359-61 . Th yroid dysfunction in children receiving neck irradia-
tion for Hodgkin’s disease. AtahanIL,YildizF,OzyarE,UzalD . Department of Radiation Oncology, Hacettepe University,
Faculty of Medicine, Ankara, Turkey.Abstract
Th yroidfunctionwasstudiedin46long-termsurvivorsofpediatricHodgkin’sdiseasewithamedianfollow-uptimeof10 .5years .Th emeanageofthepatientsatthetimeoftreatment was 8 years . Treatment consisted of radiothe-rapyaloneinsevenpatientsandcombinedradiationandchemotherapyin39patients .Th eradiotherapydosetothethyroidglandwas less than2000cGy inone,2000-2500cGyin15,2500-3000cGyin17,andgreaterthan3000cGy
22 .ActaPaediatr .1996Mar;85(3):324-6 . Long-term pulmonary function in children with
Hodgkin’s disease. IlhanI,SarialioğluF,BilgiçH,GöçmenA,Büyükpamukcu
M,AkyüzC,KutlukT . Department of Pediatric Oncology, Hacettepe University,
Ankara, Turkey.Abstract
Westudiedthelong-termpulmonaryfunctionof25pati-entswhowereatleast5yearspost-treatmentforHodgkin’sdisease .Th emeanageofthepatientswas17years(range9 .5-25years)atthetimeofstudy .Twenty-oneofthepati-entsweremale .AllpatientsreceivedsixcoursesofCOPPchemotherapyand,inaddition,8ofthe25patientsrecei-vedradiotherapytothemediastinuminlowormoderatedoses(20-30Gy) .Onepatienthadsymptomsofbronchi-ectasia .Th echestradiographsofninepatients(36%)sho-wedminimalabnormalities .Wedividedpatientsintotwogroups while evaluating their pulmonary function testsaccordingtowhethertheyreceivedmantleirradiationornot .Inpatientswhoreceivedmantle irradiation,pulmo-naryfunctiontestsshowedaminimaldecreaseinFEV1 .Th edecreaseinFEV1indicatedanobstructiveventilatorydefect .Weconcludedthatourtreatmentprotocolsforpa-ediatricHodgkin’sdiseasewerecurative,welltolerableandmightminimizepulmonaryfunctionalchanges .
23 .MedPediatrOncol .1997Dec;29(6):578-81 . Hypertrophic osteoarthropathy and intrathoracic
Hodgkin disease of childhood. KebudiR,AyanI,ErsevenG,GörgünO,DarendelilerE,
CelikA . Division of Pediatric Oncology, University of Istanbul,
Turkey.Abstract
BACKGROUND: Hypertrophic osteoarthropathy (HOA), well known in
adults, is rarely encountered in children . Th e clinical fe-atures includeclubbingof the fingersand toes, arthritis,andpainfulperiostealnewboneformationofthetubularbones .Th eassociationofmalignantdisorderswithHOAismorecommoninadultsthaninchildren .
CASE: Inthispaper,a12-year-oldboywithintrathoracicHodg-
kindiseaseandHOAispresentedandfourotherchildrenwithHOAandHodgkindiseaseintheliteraturereviewed .
DISCUSSION: Th epresenceofHOAhasbeenthoughttobeabadprog-
nostic sign, but complete remission of Hodgkin diseaseand regression of clinical signs and symptoms of HOAwere attained in our patient after chemotherapy and ra-diotherapy, and continue during 9 months post-therapyfollow-up .
CONCLUSIONS: HOAaccompanyingamalignanttumorinchildrenisvery
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28 .MedPediatrOncol .1999Apr;32(4):267-71 . Prognostic importance of magnetic resonance imaging
in bone marrow involvement of Hodgkin disease. VaranA,CilaA,BüyükpamukçuM . Department of Pediatric Oncology, Hacettepe University,
Ankara, Turkey.Abstract
BACKGROUND: Determinationofbonemarrowinvolvementisimportant
in staging Hodgkin disease (HD), so we compared theeffectivenessofmagnetic resonance imaging (MRI)withbonemarrowbiopsyindiagnosingbonemarrowinvolve-mentinHDpatients .
PROCEDURE: Twenty-sixpatientswiththediagnosisofHDwereinclu-
dedinthisstudy .Th eagesofthepatientswerebetween4and24years,withamedianof12 .Elevenofthemhadsta-geIIIorIVdiseaseand15hadbeenpreviouslydiagnosedashavingHDandwereinrelapse .Th eywereevaluatedbybonemarrowbiopsyandMRIoflumbarvertebrae .Th ebi-opsiesweretakenfromtheanterosuperioriliacspinewithanage-appropriateJamshidibiopsyneedle .Within14daysfollowing biopsy, MRI of lumbar vertebrae was carriedout .
RESULTS: MRI revealed decreased signal intensity in T1-weighted
imagesin7of26patients .Ontheotherhand,bonemar-rowbiopsiesshowedHDinvolvementinthreeoutofsevenpatients .Th eremaining19patientswhohadnormalboneMRIwerenegativeforHDintheirbonemarrowbiopsies .Th e patients with positive MRIs and negative biopsy forHDhadbonepain .Oneofthemhadafemoralperioste-alreactiononbonesurvey;theothertwohadheightlossintheirlumbarvertebralbodies .Th erewasastatisticallysignificantdifferenceinthedisease-freesurvivalratesbet-weenMRI-positiveand-negativepatientsinthefollowing24monthsperiod(P<0 .0001) .
CONCLUSIONS: Th isstudysuggeststhatMRIisausefulmethodfordiag-
nosingbonemarrowinvolvementinHD,inthatourMRI-positivepatientshadahigherrelapserateinthe24monthsfollow-upperiodthantheMRI-negativepatients .
29 .PediatrHematolOncol .1999Mar-Apr;16(2):119-29 . Hodgkin’s disease in Turkish children: clinical characte-
ristics and treatment results of 210 patients. BüyükpamukçuM,AtahanL,CağlarM,KutlukT,Akyüz
C,HazarV . Department of Pediatric Oncology, Hacettepe University Fa-
culty of Medicine, Ankara, Turkey.Abstract
AlthoughHodgkin’sdisease(HD)isoneofthecommonmalignancies in childhood, there is limited informationfromdevelopingcountries inEnglish literature .Th eaimof this study is to give epidemiologic features and treat-
in13patients .Evaluationconsistedofclinicalexaminationandthyroid functiontestsof totalandfree triiodothyro-nine, thyroxin, arid thyroid stimulating hormone levels .Twenty-oneof46patients(45 .6%)showedthyroidfunc-tionabnormalities,howeveronlynineofthemhaddiffu-se or nodular hyperplasia on physical examination . Riskfactorsofage,chemotherapyschema,totalradiationdose,and dose per fraction did not significantly influence theincidenceofthyroiddysfunction .
26 .TurkJPediatr .1999Oct-Dec;41(4):517-20 . A case of hemophilia A associated with Hodgkin’s disease. KoçA,VaranA,BüyükpamukçuM,GürgeyA . Department of Pediatrics, Hacettepe University Faculty of
Medicine, Ankara.Abstract
Lymphoreticularmalignanciesaremorecommoninpa-tientswithhemophilia,butitisusuallyattributedtohu-manimmunodeficiencyvirus(HIV)infectionassociatedwithrepeateduseofbloodproducts .However,thereareacoupleofhemophiliacpatientswithmalignanciesbutwithoutHIVinfectionintheliterature .WereportacaseofahemophiliacpatientswhohadHodgkin’sdiseaseat2 .3yearsoldwithoutanycongenitaloracquiredimmu-nodeficiencyandwithoutuseofanybloodproducts .Th ispatientshowedthatmalignancycandevelopinhemop-hiliacswithoutHIVinfection,butfurtherstudiesarene-ededtoclarifywhetherhemophiliacsaremoresusceptib-letomalignancies .
27 .PediatrHematolOncol .1999Nov-Dec;16(6):557-60 . Peripheral neuropathy during alpha-interferon therapy
in a child with Hodgkin’s disease. EmirS,KutlukT,ChanKW,YalçinB,VarliK,Büyükpa-
mukçuM . Department of Pediatric Oncology, Hacettepe University Fa-
culty of Medicine, Ankara, Turkey.Abstract
Peripheralneuropathy isoneof therarelyreportedneu-rologicalcomplicationsofinterferontherapy .Th eauthorsreport such a case in a 15-year-old boy during alpha-interferon therapy for Hodgkin’s disease . He receivedalpha-interferonatadoseof1 .8millionunits/day5timesa week by subcutaneous injections as adjuvant immu-notherapy post autologous stem cell transplant . Twentymonths after the initiation of therapy, he complained ofsevere pain in his lower distal extremities . Neurologicalexaminationrevealedtheabsenceofdeeptendonreflexes .A nerve conduction study showed a sensorial, polyneu-ropathic involvement in the lower extremities . Within 4weeksafterthestoppingofinterferon,hispainimproved,andrecoverywasalsoseenbynerveconductionstudies .Symptomsreappearedattheresumptionofinterferontre-atment . Th is study suggests that peripheral neuropathymay rarely occur in patients given long-term interferontreatmentathighcumulativedosage .
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER30
tinentliterature .Ourexperienceamong661childrenwithHDrevealedtencases(1 .5%)withnephropathy;eightofthesewerebiopsyproven .Tissuediagnoseswereamyloi-dosis(AAtype)infourcases,andmembranoproliferativeglomerulonephritisandminimalchangeglomerulopathyintwocaseseach .Sexdistributionwasequal .Th erewasapredominanceofthemixedcellular(MC)histologictypeinourpatientswithHD .Nephropathywasshowntoan-tedate thediagnosisofHD in twocases and toheraldarelapseinone .Inbrief,thedevelopmentofanephropathyinapatientwithHDcanbeconsideredasaparaneoplasticphenomenon .Renal amyloidosismayalreadybepresentatthetimeofdiagnosisofHDandmustbekeptinmindasacauseofproteinuriaduetopreexistingnephropathy .Developingrenalparaneoplasticsyndrome,eveninearly-stagedHD,inchildren,maybeapoorprognosticfactor .
33 .JPediatrHematolOncol .2000Mar-Apr;22(2):158-61 . Paraneoplastic cerebellar degeneration and Horner
syndrome: association of two uncommon findings in a child with Hodgkin disease.
EmirS,KutlukMT,GöğüşS,BüyükpamukçuM . Department of Pediatric Oncology, Hacettepe University Fa-
culty of Medicine, Ankara, Turkey.Abstract
An 11-year-old boy admitted with a right cervical masswasfoundtohaveHodgkindisease .Onadmission,healsohad rightHomer syndromeand severe cerebellar ataxia .CranialMRIrevealedmarkedcerebellaratrophy .Hewastreatedwithchemotherapyconsistingofdoxorubicin,ble-omycin,vinblastine,anddacarbazine(ABVD),inadditiontoradiotherapy .Th reemonthsafter initiationoftherapy,hehadapartialremissionoftumor .Neurologicsymptomsimproveddramaticallyafterchemotherapystarted .Hodg-kindiseaseshouldbeincludedinthedifferentialdiagnosisofchildrenwithcerebellarfindingsandHornersyndrome .
34 .PediatrHematolOncol .2000Mar;17(2):181-5 . Immune thrombocytopenia and hemolytic anemia as a
presenting manifestation of Hodgkin disease. ErtemM,UysalZ,YavuzG,GözdaşoğluS . Ankara University School of Medicine, Department of Pedi-
atrics, Turkey. Abstract
A very unusual clinical presentation of Hodgkin diseasewith immune thrombocytopenia and autoimmune he-molyticanemiaisreported .A6 .5-year-oldboypresentedwiththrombocytopenia,Coombs’positivehemolyticane-mia, and multiple small posterior cervical lymph nodes .After a course of high-dose methylprednisolone therapywith a diagnosis of Evans syndrome, complete responseforthrombocytopeniaandpartialresponseforanemiawasachieved .SixweekslatertherewasasuddenincreaseinthesizeofleftposteriorcervicallymphnodesandabiopsywascompatiblewithHodgkindisease,mixedcellularitytype .Th echildwassuccessfullytreatedwithchemotherapyand
ment results of 210 previously untreated children withHDfromadevelopingcountry .Between1June1984and31 December 1992, all children seen who were youngerthan18yearsoldwithnewlydiagnosed,untreated,biopsy-proven Hodgkin’s disease were included in this study . Aclinicalstagingsystemwasusedtodeterminethedissemi-nationofthedisease .WhilepatientswithstageI-IIdiseasereceived canapé treatment protocol (three cycles COPP[cyclophosphamide, vincristine, procarbazine, predni-solone] or ABVD [doxorubicin, bleomycine, vinblastine,dacarbazine] plus low-dose involved-field radiotherapy),patientswithstageIII-IVdiseaseweretreatedbysandwichprotocol(sixcyclesCOPPpluslow-doseinvolved-fieldra-diotherapy) .Atotalof210patientswithamedianageof8 years were eligible for this study . Male to female ratiowas3:1and37(17 .6%)werelessthan5yearsofage .Th emajor histologic subtype was mixed cellularity (69 .6%) .Overallsurvivalrateswere91 .5and87 .7%,andevent-freesurvivalrateswere71 .5and70 .5%at5and10years,res-pectively .Nosecondarymalignancyhasbeenobservedsofar .Th eprevalenceofHodgkin’sdiseaseinyoungchildrenishigherandthedistributionofhistologicsubtypesisalsodifferentfrommanyWesterncountries .Canapéandsand-wichtreatmentprotocolscouldbeusedsafelyinclinicallystagedchildhoodHDwithtolerabletoxicity .
30 .MedPediatrOncol .1999Jan;32(1):18-24 . Hodgkin disease in children: clinicoepidemiologic and
viral (Epstein-Barr virus) analyses. CavdarAO,PamirA,GözdaşogluS,BabacanE,YavuzG,
UnalE,UluogluO,TaçyildizN,IkincioğullariA . Pediatric Hematology and Oncology Research Center, Anka-
ra University, Turkey. 31 .MedPediatrOncol .2000Nov;35(5):509 . Ataxia telangiectasia and Hodgkin disease. KutlukMT,YalçinB,BüyükpamukçuM . Department of Pediatrics, Hacettepe University Faculty of
Medicine, Ankara, Turkey. Comment on Fataloutcomeintwogirlswithhodgkindiseasecompli-
catingataxia-telangiectasia(Louis-Barsyndrome)despitefavorableresponsetomodified-dosechemotherapy .[MedPediatrOncol .2000]
32 .TurkJPediatr .2000Apr-Jun;42(2):109-14 . Hodgkin’s disease and renal paraneoplastic syndromes
in childhood. BüyükpamukçuM,HazarV,TinaztepeK,BakkaloğluA,
AkyüzC,KutlukT . Department of Pediatrics, Hacettepe University Faculty of
Medicine, Ankara, Turkey.Abstract
Th epurposeofthisstudywastoinvestigatechildrenfol-lowedashavingbothHodgkin’sdisease(HD)andneph-ropathyanddiscussthefactorswhichmightplayrolesinthepathogenesisofthisassociationbyreviewingtheper-
31KONU 2 Lenfoma
on 3 cases of AT with HD who had mediastinal diseaseandparenchymalpulmonaryinvolvementwithcavitation .Of6ATpatientsinourHDseries,3developedpulmonarycavities .Th epatientsdisplayedpulmonaryinfiltration,ca-vitationinthelungparenchyma,andmediastinalenlargedlymphnodesonbothplainchestX-raysandthoraciccom-putedtomographies .Noinfectiousetiologieswereestab-lishedforthepulmonaryfindings .Histopathologicalexa-minationofopenlungandmediastinalbiopsiesrevealedHD,andallpatientsreceivedmultiagentchemotherapies .Th eoutcomewasfatalinall3patients .Respiratoryinfec-tionsaretheprinciplecauseformorbidityandmortalityin AT patients . Reports on cavitating pulmonary lesionsinHDarequiterare .Furthermore,dataregardingthepat-terns of pulmonary involvement in AT patients with orwithoutHDare lacking .Th e increased incidenceofma-lignanciesinATpatientsmayrelatetoimmunodeficiencyandtothechromosomalalterationsidentified .
39 .AnalQuantCytolHistol .2002Oct;24(5):249-53 . Prognostic role of natural killer cells in pediatric mixed
cellularity and nodular sclerosing Hodgkin’s disease. OrtaçR,AktaşS,DinizG,ErbayA,VerginC . Department of Pathology and Pediatrics, Dr. Behcet Uz
Children’s State Hospital, Izmir, Turkey. Abstract
OBJECTIVE: Tostudynaturalkillercells’spontaneouscytotoxiccapa-
cityagainsttumorcellsandtheirprognosticsignificanceinclassicalHodgkin’sdisease .
STUDY DESIGN: Th irty-eightpediatricmixedcellularityandnodularscle-
rosing Hodgkin’s disease patients were included in thestudy .Immunohistochemicalstainingwasperformedfornaturalkillercellsinthebackgroundusingthemonoclo-nalantibodyCD57inserialsectionsofB5-formalin-fixed,paraffin-embeddedtissueblocks .CD57-positivecellswerecountedwithanimmersionobjectiveamong5,000cellsonrepresentativeareasof thetumors .Th edegreeofnaturalkillercellswasclassifiedaslow(<150cells)orhigh(>or=150cells) .Multivariateregressionanalysiswasperformedto determine the differences between patients with andwithoutrelapse .
RESULT: Th e mean of CD57-positive cell numberfor all the cases
was173 .42+/-117 .34(range,20-500) .CD57-positivecellswerehighin21casesandlowin17 .Th emeanofCD57-positivecellnumberswas191 .85+/-115 .33inthedisease-free group and 84 .44 +/- 57 .90 in the relapsing group .Logrankanalysisshowedstatisticalsignificancebetweenevent-freesurvivalandnumberofCD57-positivecells(P= .0207) .
CONCLUSION: Inmultivariateanalysis,CD57expressionprovedtobea
prognosticfactorindependentfromotherfactors .Asare-
radiationtherapy .Hehasbeenofftherapyfor28monthsandhasnoclinicalorlaboratoryevidenceofautoimmunecytopenia .Acombinationofimmunethrombocytopeniaand autoimmune hemolytic anemia may be associatedwithHodgkindisease .Th erecognitionofthisclinicalpic-tureasacomplicationofHodgkindiseasehasimportantimplications . Th is complication appeares to be managedbestbythedefinitivetreatmentofHodgkindisease
35 .PediatrHematolOncol .2000Mar;17(2):133-9 . Natural killer cell numbers and cytotoxic activity in pe-
diatric Hodgkin disease. Ikincioğullari A, Doğu F, Babacan E, Oflaz G, Ertem U,
YavuzG,UnalE,GözdaşoğluS,TaçyildizN,DağdemirA,CavdarAO .
Department of Pediatric Immunology-Allergy, Ankara Uni-versity Medical School, Turkey.
Abstract Inthisstudyperipheralbloodnaturalkiller(NK)cellacti-
vitywasevaluatedin17pediatriccaseswithHodgkindise-ase(HD)(9untreated,8inremission)and20age-matchedhealthychildren .PeripheralbloodCD16andCD56mole-culeexpressionswerealsoexamined .NodifferencerelatedtoNKcellnumbersandcytotoxicactivitywasdetectedateitherstageofthedisease .Incasesinwhichlong-termre-missionhasbeenachieved(>or=5years)NKcellactivitywasslightlybutnotsignificantlyincreasedinparallelwithremissionduration .Finally,no relationbetweenNKcellactivityandtheetiology,prognosis,andseverityofthedi-seasehasbeenestablishedinchildrenwithHD .
36 .PediatrHematolOncol .2001Jan-Feb;18(1):79-82 . Hypertrophic osteoarthropathy and childhood Hodg-
kin disease. KaradenizC,OguzA,DalgiçN . Department of Pediatrics,, Gazi University Faculty of Medi-
cine, Beşevler/Ankara, Turkey.37 .MedPediatrOncol .2001Mar;36(3):398-9 . Th e vanishing bile duct syndrome in a child with Hodg-
kin disease. OzkanA,YorukA,CelkanT,ApakH,YildizI,OzbayG . Department of Pediatric Hematology-Oncology,
Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey.
38 .PediatrPulmonol .2002May;33(5):399-403 . Hodgkin’s disease and ataxia telangiectasia with pulmo-
nary cavities. YalçinB,KutlukMT,SanalO,AkyüzC,AnadolD,Cağlar
M,GöçmenA,BüyükpamukçuM . Department of Pediatric Oncology, Institute of Oncology,
Hacettepe University, Ankara, Turkey.Abstract
Ataxiatelangiectasia(AT)homozygoteshaveanincreasedriskfordevelopmentofHodgkin’sdisease(HD) .Parench-ymallunginvolvementisnotuncommoninHD;however,cavitarypulmonary lesionsarequiteunusual .Wereport
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER32
lymphomaassociatedwithcysthydaticdiseasefromTur-key .Th eauthorsreportsuchacaseofHodgkinlympho-ma . Intrahepatic cystic masses were diagnosed duringultrasoundexaminationforclinicalstagingonadmission .Th ediagnosisofcysthydaticoftheliverwasconfirmedbysurgery .Althoughtherewasnoresidualand/ornewcystformationonradiologicfollow-up,elevatedantibodytiters(indirecthemagglutinationtest)persistedfollowingsurgi-calexcisionatleastfor2yearsoffollow-up .
43 .PediatrHematolOncol .2005Oct-Nov;22(7):589-96 . Intracranial involvement in Hodgkin’s disease. AkyüzC,YalcinB,AtahanIL,VaranA,KutlukMT,Bü-
yükpamukçuM . Hacettepe University Institute of Oncology, Department of
Pediatric Oncology, Ankara, Turkey. Abstract
Th eauthorsreport3casesofHodgkin’sdiseasewithint-racranialinvolvement .Th epatientswere4,12,and15ye-arsold(male/female=1/2) .Initially,theyweretreatedwithABVD or COPP chemotherapies and low-dose involvedfield radiotherapy . Intracranial recurrences occurred 27,40,and42monthsafterinitialdiagnosis,respectively .Twopatientsexperiencedconvulsionsandtheothercomplai-nedofdiplopia .Th emetastatic lesionswerelocatedsup-ratentorially with CT or MRI . Despite initial responseachieved following systemic chemotherapy and externalirradiationtocraniallesions,allpatientsdiedwithdisse-minateddisease .InpatientswithintracranialinvolvementofHodgkin’sdisease,prolongeddisease-freesurvivalmaybeachievedbycombinedmodalitytreatment .
44 .PediatrBloodCancer .2005Oct15;45(5):670-5 . Prognostic factors and treatment outcome in childhood
Hodgkin disease. OguzA,KaradenizC,OkurFV,CitakEC,PinarliFG,Bora
H,AkyurekN . Department of Pediatrics, Professor of Pediatric Oncology,
Chief of Division, Gazi University Faculty of Medicine, Be-şevler/Ankara, Turkey.
AbstractBACKGROUND:
Th egoalsofthisstudyincluded:(1)Identificationoffac-tors prognostic for event-free survival (EFS) and overallsurvival (OS), and (2) Definition of risk groups for riskadaptedtherapyinchildrenwithHodgkindisease(HD) .
PROCEDURE: From 1991 to 2003, 69 children with newly diagnosed,
untreatedbiopsy-provenstageI-IVHDweretreatedwithchemotherapy(CT)andlow-doseinvolvedfieldradiothe-rapy(LD-IFRT) .Th erelationshipofpretreatmentfactorstoEFSandOSwasanalyzedbyunivariateandmultivariateanalysis .
RESULTS: Th e5-yearEFSandOSforallpatientswere90 .77%and
96 .22%,respectivelywithamedianfollow-upof73months
sult, CD57 expression by background natural killer cellsmaybeusedasaprognosticparameterinmixedcellularityandnodularsclerosingHodgkin’sdisease .
40 .HematolJ .2003;4(1):78-81 . Pulmonary tuberculosis in children with Hodgkin’s
lymphoma. KarakasZ,AgaogluL,TaravariB,SaribeyogluE,SomerA,
GulerN,UnuvarA,AnakS,YalcinI,DeveciogluO . Department of Pediatrics, Istanbul School of Medicine, Is-
tanbul University, Turkey. Abstract
Th e clinical presentation of tuberculosis (TB) andHodgkin’slymphoma(HL)withpulmonaryinvolvementissimilarandraisesproblemsofdifferentialdiagnosis .ItmayalsobedifficulttodistinguishTBfromrelapsedlymphoma .Th epurposeofthisstudywastoevaluatetheassociationofHLandpulmonaryTBandtodiscussdifferentialdiagno-sis .Medical recordsof70childrenwere reviewedretros-pectively . A total of 27 patients (38%) had mediastinal-pulmonaryinvolvementinitially .Systemicsymptomswerepresentin37(52%)patients .Inall,14patients(20%)hadpulmonaryTB;threeofthemwerediagnosedashavingTBbeforeHL,twoofthemhadTBandHLconcomittantlyatinitialdiagnosis,sevenofthemduringlymphomatherapyandtwoofthemafterthecessationoflymphomatreatment .PPDwaspositive(>10mm)onlyinsevenpatients .Inall,11patientswithpulmonaryTBhaddiffusepulmonaryin-filtrations and mediastinal enlargement at lung contrast-enhanced computed tomography and X-ray, which wasdifficulttodifferentiatefromHL .Biopsieswereperformedinfivepatients .Nomortalitybecauseoftheinfectionwasseen .Onlyonepatienthadbeenlostasrelapsed-resistantHL . To evaluate mediastinal lymphadenopathies is verycrucialandthedifferentialdiagnosisisdifficult;hencetheassociationbetweenHLandtheTBmustbeconsideredes-peciallyincountrieswhereTBishighlyendemic .
41 .BiolTraceElemRes .2003Feb;91(2):191-2 . Th e strong correlation between serum copper level and
the copper/zinc ratio to histopathological changes, cli-nical stage, and prognosis of Hodgkin’s disease.
GözdaşoğluS,AkarN . Department of Pediatric Immunology-Allergy, Ankara Uni-
versity Medical School, Turkey.42 .PediatrHematolOncol .2004Mar;21(2):95-9 . Coexistence of Hodgkin lymphoma and cyst hydatic di-
sease of the liver. YavuzG,EmirS,UnalE,TaçyildizN,GençgönülH,Yag-
murluA,FitözS,ErekulS . Department of Pediatric Oncology, Ankara University Fa-
culty of Medicine, Ankara, Turkey.Abstract
Although both Hodgkin lymphoma and cyst hydatic di-sease in children have been seen with an increased fre-quency, there isnopreviously reportedcaseofHodgkin
33KONU 2 Lenfoma
46 .JPediatrHematolOncol .2006Apr;28(4):234-6 . Hodgkin lymphoma in a child with Diamond Blackfan
anemia. YarisN,ErduranE,CobanogluU . Department of Pediatric Oncology, Karadeniz Technical
University Faculty of Medicine, Trabzon, Turkey. Abstract
Diamond Blackfan anemia (DBA) is a rare disease cha-racterized by aplasia or hypoplasia of erythroid lineage .Normochromic,usuallymacrocytic,butoccasionallynor-mocytic anemia and reticulocytopenia are characteristicfindingsofDBA .DBAisassociatedwithanincreasedriskofmalignancy .Mostofthereportedmalignanciesareacu-temyeloidleukemia .Solidtumorsincludinghepatocellu-larcarcinomaandosteosarcomahavealsobeenidentified .Wecouldfind29reportedcaseswithDBAandmalignancy .TwoofthemwerediagnosedasHodgkinlymphomaat15and23years,respectively .Herewereporta7-year-oldboywithDBAwhodevelopedHodgkindisease .
47 .LeukRes .2006Jul;30(7):899-902 .Epub2005Nov28 . Hypertrophic osteoarthropathy and intrathoracic
Hodgkin’s disease in children. KebudiR,AyanI,GörgünO,AğaoğluFY,DizdarY,Da-
rendelilerE . Istanbul University, Oncology Institute, Division of Pediatric
Oncology, Turkey. Abstract
BACKGROUND: Hypertrophicosteoarthropathy(HOA)isasyndromecha-
racterizedbyclubbingof the fingersand toes,periostealnewboneformationofthelongbonesandpolyarthritis .
CASE REPORT: In thisreport, twochildrenwith intrathoracicHodgkin’s
diseaseandHOAarepresented .CONCLUSIONS:
Intrathoracic neoplasms are one of the major causes ofHOA in adults; however HOA is rarely associated withintrathoracic malignancies in children . HOA associatedwithintrathoracicHodgkin’sdiseaseisevenmorerare,butshouldbekeptinmind
48 .TurkJPediatr .2007Apr-Jun;49(2):218-22 . Osseous presentation of Hodgkin’s disease: a case report
and review of the literature. KöseoğluRD,SenayliA,BiçakçiU,Onuk-FilizN,SezerT,
CelkanT . Department of Pathology, Gaziosmanpaşa University, Fa-
culty of Medicine, Tokat, Turkey.Abstract
Th eboneinvolvementinthelaterstagesofHodgkin’sdise-aseisanexpectedphenomenon,butitisveryrareinearlystagesofthedisease .About49casesofHodgkin’sdiseasepresentingwithboneinvolvementhavebeenreportedintheliterature .Wereporteda14-year-oldboyinitiallyeva-luatedwithpainlocalizedattheleftilium .Althoughallthe
(3-137months) .Maletofemaleratiowas3:1and21child-ren(32 .3%)werelessthan7yearsofage .Mixedcellularitywasthepredominanthistologicsubtype(38 .5%) .Factorsassociated with inferior EFS by univariate analysis wereextranodaldisease,hemoglobinlevel<11g/dl,numberofinvolved lymph node regions and stage . By multivariateanalysisonlystageIVdiseasewassignificant .
CONCLUSION: Our study confirms that excellent results are achievab-
lewithcombinedmodalitytherapyinchildhoodHD .Inorder to use risk-adapted therapy in children with HD,clinicalprognosticfactorsshouldbevalidatedwithlarge,multicenteredprospectiveclinicalstudies .
45 .SaudiMedJ .2005Apr;26(4):571-5 . Hodgkin’s disease and association with Epstein-Barr vi-
rus in children in Southeast Turkey. YilmazF,UzunlarAK,SogutcuN,OzaydinM . Department of Pathology, Faculty of Medicine, Dicle Uni-
versity, Diyarbakir, Turkey. Abstract
OBJECTIVES: Th erearerelativelyfewreportsonhistologicandimmu-
nophenotypicfeaturesofHodgkin’sdisease(HD)inchild-reninTurkey .Th eaimofthepresentstudyistocharacteri-zetheclinicopathologic,immunophenotypicfeaturesandEbstein-Barrvirus(EBV)statusofHDinchildreninourregion .
METHODS: Fifty-twocasescodedasHDintheDepartmentofPatho-
logy,MedicalFaculty,DicleUniversity,Turkey,from1990to 2002 were retrieved . We analyzed clinicopathologicdata,immunophenotype,andEBVstatusofallpatients .
RESULTS: Inmost cases, thecervical lymphnodeswere involved .
Th e52cases(35boys,17girls;maletofemaleratiowas2 .1) were categorized as mixed cellularity (MC) in 23(44 .2%), lymphocytepredominance(LP) in16(30 .8%),nodular sclerosis (NS) in 10 (19 .2%), and lymphocytedepletion (LD) in 3 (5 .8%) . Of 33 cases, including MCand NS, Hodgkin’s Reed-Sternberg cells and variantswere positive for CD15 in 27 cases (81 .8%) and positi-veforCD30in30cases(90 .9%) .AllthecasesofLPde-monstrated the characteristic phenotype of this variant(CD45RB+,CD20+,CD15-,CD30-) .Epithelialmembra-neantigenstainedthelymphocytic/histiocyticcellsin3cases(18 .7%)of16 .Epstein-Barrvirus-LMP1wereposi-tivein31cases(61 .5%)ofatotalof52casesandthemostwereMC(91 .3%) .
CONCLUSION: Inconclusion,mixedcellularityHDisthemostcommon
histologicsubtype .Th isresultdifferedfromthatreportedin developed countries . We found a striking associationwithexpressionofEBV-latentmembraneprotein1inma-lignantcellsinchildhoodHD .
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER34
motherapy .Atthirdandfourthmonthofpostchemothe-rapy follow-up, increased Gallium uptake and positiveFDG-PET/CT in right lower quadrant of abdomen wasobserved .Openbiopsyrevealedlymphoidhyperplasia .Hehasbeenfollowedfor21monthswithoutanyevidenceofdisease . Despite its documented benefit, we believe thatresultsofFDG-PET/CTshouldbeinterpretedwithgreatcautioninordertoavoidunnecessaryinterventions .
52 .PediatrHematolOncol .2008Mar;25(2):159-61 . Breast involvement in nodular lymphocyte predomi-
nant type Hodgkin lymphoma in childhood. AksuG,InanN,CorapciogluF,TugayM,AnikYA .53 .PatholResPract .2008;204(2):89-96 .Epub2008Jan18 . Immunohistochemical expression of angiogenic cytoki-
nes in childhood Hodgkin lymphoma. CitakEC,OguzA,KaradenizC,AkyurekN . Department of Pediatric Oncology, Faculty of Medicine,
Gazi University, Huseyin Onat Sokak, No. 15/13, Asagiay-ranci, Ankara 06510, Turkey.
Abstract Th isimmunohistochemicalstudywascarriedouttoevalu-
atetheroleofvascularendothelialgrowthfactor(VEGF),matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), their inhibitor (tissue inhibitorofmetalloproteinase-1,TIMP-1),andmicrovesseldensity(MVD)intheclinicopat-hologicbehaviorofchildhoodHodgkin’slymphoma(HL) .Paraffin-embedded histologic sections from 15 childrenwithHLwereimmunohistochemicallystainedwithMMP-2,MMP-9,TIMP-1,VEGF,andCD31antibodiestoinvesti-gatethecorrelationbetweentheexpressionofthesemarkersandtheclinicopathologiccharacteristicsofHL .ExpressionofMMP-2andVEGFinHodgkinandReed-Sternbergcells(HRS)wasmore frequent innodularsclerosis than inot-her subtypes (p=0 .07 and 0 .08, respectively) . None of thestudy parameters in HRS cell were associated with age,sex, disease stage, extranodal disease, and the occurrenceofbulkytumor .Th erewasa trendtowardadvancedstageinnegativeTIMP-1staining inHRScells (p=0 .06) . Inre-active lymphocytes, MMP-2 expression was correlatedwithMVD(r=0 .68,p=0 .005),andMMP-9expressionwascorrelatedwithBsymptoms(p=0 .003) .Also, lowTIMP-1expressioninreactivelymphocyteswasfrequentlyfoundinpatientswithadvancedstage(p=0 .048) .Th erewasapositivecorrelationwiththeratioofMMP-2expressioninreactivelymphocytes and MVD (r=0 .68, p=0 .005) . Expression ofMMP-9inreactivelymphocyteswascorrelatedwithMVDwithout statistical significance (r=0 .487, p=0 .06) . Our re-sultssuggestthat,asinmanysolidtumors,angiogenesisandangiogenicfactorsmayplayanimportantroleinchildhoodHL .Larger seriesofpatientsareneeded todetermine theprognosticvalueofangiogenesisinchildhoodHL .
54 .JTh oracOncol .2008Aug;3(8):915-6 . Superior vena cava syndrome in a child and venous col-
lateral pathways: MDCT imaging.
radiologicalexaminationssuggestedanosseousanomaly,histopathologic evaluation of the pelvic lymphadenopat-hiesprovideddefinitediagnosisofthedisease .WediscussthepossibledifferentialdiseasesandreviewtheliteratureregardingtheosseouspresentationofHodgkin’sdisease .
49 .PediatrBloodCancer .2008Jun;50(6):1290 . Cerebellar dysfunction caused by procarbazine and
consumption of excessive amount of bananas. KüpeliS,VaranA,BüyükpamukçuM . Hacettepe University Institute of Oncology, Department of
Pediatric Oncology, Ankara, Turkey. 50 .EurJPediatr .2008Apr;167(4):419-23 .Epub2007Jun29 . Childhood intrathoracic Hodgkin lymphoma with
hypertrophic pulmonary osteoarthropathy: a case re-port and review of the literature.
UtineEG,YalçinB,KarnakI,KaleG,YalçinE,DoğruD,KiperN,AkyüzC,BüyükpamukçuM .
Department of Pediatrics, Division of Chest Diseases, Ha-cettepe University Sihhiye, 06100, Ankara, Turkey.
Abstract Hypertrophic osteoarthropathy (HOA) is characterized
byclubbing,periostealnewboneformationandpolyart-hritis .Th epathogenesisofclubbinginvolvesanincreasedexpressionofplatelet-derivedgrowthfactor(PDGF)andvascular endothelial growth factor (VEGF) from the di-gitally lodged platelet clumps, which bypass the pulmo-narycapillarynetworkasaresultofvarioussystemicdi-sorders .IntrathoracicneoplasmsarerarecausesofHOAinchildren .Wereportherea14-year-oldboywithdigitalclubbing,whoeventuallyreceivedthediagnosisofintrat-horacicHodgkin lymphoma(HL)andHOA .EightcasespreviouslyreportedwiththesetwodiagnosesarereviewedtoemphasizetheprognosticsignificanceofHOAinchild-hoodHL .CONCLUSION:Giventhepathogenesisofclub-bingandtheprognosticsignificanceofHOA,intrathora-cicdiseaseshouldbeconsideredwhenHOAisdetectedinachildwithaknownorsuspectedmalignantdisease,andtheoccurrenceofHOAduringfollow-upshouldalertthephysiciansforpossiblerecurrenceoftheneoplasticdiseaseorintrathoracicinvolvement .
51 .PediatrBloodCancer .2008Apr;50(4):881-3 . False positivity of FDG-PET/CT in a child with Hodg-
kin disease. BekerDB,BerrakSG,CanpolatC,TugtepeH,OnesT,Te-
cimerT . Pediatric Hematology-Oncology, Marmara University Me-
dical Center, Altunizade, Istanbul, Turkey.Abstract
RoleofPositronEmissionTomography(PET)withF-18-2-fluoro-2-deoxy-D-glucose(FDG)instagingofHodgkindisease is well established despite several controversies .We report a Stage III Hodgkin lymphoma patient withfalse positive FDG-PET/CT results . Seven-year-old malewithHodgkinlymphomawasinremissionatendofche-
69
1953-2011yıllarıarasındatoplam281adetMerkezisinirsistemitümörlerikonuluyayıntespitedilmiştir .Buyayınlarınçoğun-luğunöroşirurjibilimdallarıncavesıklıklaanatomikaltgruplaragöreraporedilmiştir .Bunedenlehistopatolojiyegöretambirsınıflamayapmakmümkünolmamıştır .Ensıkglialtümörlereaityayıntespitedilmişolup(90),ikincisıradakarışıkhastagruplarınaaityayınlaryeralmaktadır(örneğin;posteriorfossatümörleri) .
Tablo 1. MSS yayınlarının 123 adedi derleme, özgün araştırma ve seri çalışma şeklinde olup, 158 adedi editöre mektup ve olgu sunumlarından oluşmaktadır.
TANI YAYIN SAYISIGlial tümörler 85
Birden fazla tanılı yayınlar 57
Diğer 51
Embiryonal tümörler 39
Koroid pleksus tümörleri 13
Tablo 2. MSS tümörleri konusunda en çok birinci isim yayını olan yazarlar
YAZAR ADI BİRİNCİ İSİM YAYIN SAYISIR Nuri Şener 11
Yusuf Ersahin 8
İsmail H Tekkök 8
Mehmet Turgut 8
Burçak Bilginer 6
Su Berrak 5
Memet Ozek 5
Canan Akyüz, Necmettin Pamir, Ali Varan, Nalan Yazıcı, Faruk Zorlu
4
3 Merkezi Sinir Sistemi Tümörleri
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER70
Tablo 3. MSS tümörleri konusunda yazar sırası gözetilmeksizin en çok yayını olan ilk 10 yazar
YAZAR YAYIN SAYISINejat Akalan 29Figen Soylemezoglu 23Münevver Buyukpamukcu 18Yusuf Erşahin 18Memet Özek 16Tezer Kutluk 14Canan Akyüz 13Necmettin Pamir 13Aydın Sav 13Faruk Zorlu 13
Tablo 4. MSS tümörleri yayınlarına göre en çok yayını olan ilk 10 kurumKURUM YAYIN SAYISIHacettepe Üniversitesi 70Ege Üniversitesi 30İstanbul Üniversitesi 26Marmara Üniversitesi 19GATA 11Acıbadem Üniversitesi 7Gazi Üniversitesi 7Adnan Menderes Üniversitesi 7Ankara Üniversitesi 6Çukurova ve Karadeniz Teknik Üniversiteleri 5
Tablo 5. Yayın sitasyon sayısına göre ilk 10 yayın
YAZAR ADI KURUM YIL ÇALIŞMA ADI DERGİ ADI ÇALIŞMA TİPİ
SİTASYON SAYISI
Ozek MMMarmara Uni
1996Intramedullary spinal cord tumors in children under the age of 3 years
J NeurosurgSeri çalışma
96
Kutluk THacettepe Uni
1997Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomas
Clin Cancer Res
Özgün araştırma
89
Ersahin Y Ege Uni 1996Cerebellar mutism: report of seven cases and review of the literature
NeurosurgerySeri çalışma
78
Erdincler PIstanbul Uni 1998
Intracranial meningiomas in children: review of 29 cases Surg Neurol
Seri çalışma 57
Hakyemez BUludag Uni
2006Evaluation of di� erent cerebral mass lesions by perfusion-weighted MR imaging
J Magn Reson Imaging
Özgün araştırma
40
Ersahin Y Ege Uni 1997Cerebellar mutism: report of two unusual cases and review of the literature
Clin Neurol Neurosurg
Vaka takdimi
40
Gokay HIstanbul Uni 1984 Supratentorial intracerebral schwannomas Surg Neurol
Vaka takdimi 34
Turgut MAdnan Menderes Uni
1998 Transient “cerebellar” mutismChilds Nerv Syst
Derleme 33
Yurtseven T Ege Uni 2003 Neuroendoscopic biopsy for intraventricular tumorsMinim Invasive Neurosurg
Seri çalışma
31
Erdogan CUludag Uni
2005Brain abscess and cystic brain tumor: discrimination with dynamic susceptibility contrast perfusion-weighted MRI
J Comput Assist Tomogr
Seri çalışma
31
71KONU 3 Merkezi Sinir Sistemi Tümörleri
servationssuggestthatincreaseintheamountofmucoidmaterialmaycontributetorapidenlargementofintraor-bitalandintracranialopticgliomas .
3 . RadiotherOncol .1992Apr;23(4):245-8 . Results of post-operative or exclusive radiotherapy in
grade I and grade II cerebellar astrocytoma patients. AkyolFH,AtahanIL,ZorluF,GürkaynakM,AlanyaliH,
OzyarE . Department of Radiology, Hacettepe University Faculty of
Medicine, Ankara, Turkey.Abstract
43 Patients with the diagnosis of cerebellar astrocytomawere post-operatively treated, between 1 January 1976and31December1985 .Th eiragerangedbetween2and51yearswithamedianof13 .Th erewere22malesand21females .Th etumourswerereportedasgradeIin18,andgradeIIin25patients .Th eprimarysurgicalinterventionwasintheformofbiopsyin3,subtotalexcisionin24andmacroscopictotalexcisionin16 .Allpatientsweretreatedwithcobalt-60teletherapyunit,toatotaltumourdoseof4500-5500cGyin6-7weeks .Th eobtained5and10yearactuarialsurvivalratesare78%and78% .Ourstudygivesthe impression that, age, sex and tumour grade are notdetermining factors in survival and post-operative radi-otherapyimprovesprognosis incases treatedbysubtotalexcision while it remains unnecessary in those who hadundergonetotalsurgicalremoval .
4 . JChildNeurol .1993Oct;8(4):354-6 . Intramedullary astrocytoma presenting as spinal mus-
cular atrophy. AysunS,CinbişM,OzcanOE . Department of Paediatric Neurology, Hacettepe University
Faculty of Medicine, Ankara, Turkey.Abstract
Wepresenta6-year-oldpatientwithaspinalcordtumorwhohadbeenfollowedwiththediagnosisofspinalmuscu-laratrophysincetheageof23months .Reasonsforreeva-luatingthediagnosisofspinalmuscularatrophyweretheearlyonsetofscoliosis,theslightasymmetryinweaknessofextremities,andtheappearanceofurinaryretentioninthe last 3 days . Magnetic resonance imaging revealed averylong,intramedullarytumorextendingfromthelevelof theseventhcervical segment to theconusmedullaris,later reported tobeagrade I astrocytoma .We thereforerecommendthatmagneticresonanceimaging,anoninva-siveandsensitivetechniqueforintraspinalpathologies,beperformedineverypatientwithanatypicalformofspinalmuscularatrophy .
1 . Neurochirurgie .1984;30(3):153-8 . Intracranial ependymomas. Study of 81 cases and com-
parison with the literature. NamerIJ,PamirMN,BenliK,ErbengiA . Hacettepe University, Ankara, Turkey.
Abstract Forten-yearsofperiod,between1973-1982,81caseswith
intracranialependymomahavebeenoperatedinH .U .T .F .Neurosurgery Department . Supratentorial localisationhavebeenfoundin24cases(30%),and infratentorial in57(70%) .80%ofthepatientsinsupratentorialgroupand91%ininfratentorialgroupwereundertheage20 .Insup-ratentorialgroup79%wereinparaventricularlocalisation,and21%wereintraventricular .Ininfratentorialgroup70%ofthecaseswerelocalisedwithintheIV .ventricle,20%inprovince of the tentorial roof, 5% in the lateral recessusand5%intocerebellum .Th e40patientswhowerefollo-wed up were rated according to the localisation and thegradesofthetumors,thetypeofthesurgicalinterventionandchemotherapywithrespecttothepostoperativesur-vival .Asaresultonlythetotalresectionofthetumorwasfoundtobesignificant .
2 . BrJOphthalmol .1989Oct;73(10):832-7 . Optic glioma of childhood: clinical, histopathological,
and histochemical observations. BilgiçS,ErbengiA,TinaztepeB,OnolB . Department of Ophthalmology, Hacettepe University, Anka-
ra, Turkey.Abstract
Th isreportdocumentsthe long-termclinicalandhisto-pathological behaviour of eight intraorbital and 16 int-racranialopticnervegliomasandrelatesthetherapeuticdatatotheprognosisforbothvisualacuityandsurvival .Th emeanageatonsetofsymptomswas8 .6yearsandatthediagnosis10 .9years .Itisgenerallyheldthatproptosisismild in intraorbitalglioma,butweencounteredmar-kedproptosisrangingfrom7to12mminsixoftheeightintraorbital gliomas, which contained abundant Alcian-blue-positive mucoid material . Of the patients with int-racranialopticnervegliomas37 .5%survivedforameanof eight years after treatment with radiotherapy or sur-gery combined with radiotherapy . At follow-up rangingfromfivemonthsto11yearsonlyoneofthesixpatientswithintracranialgliomashadfullvisualacuity .Ourob-servationsemphasise that,althoughopticnervegliomasare benign hamartomas, the prognosis for visual acuityandsurvivalisunfavourableincaseswhicharediagnosedandtreatedlate .Histopathologicalandhistochemicalob-
GLİAL TÜMÖRLER
YAYINLAR
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER72
exploredtranscraniallyanddecompressionoftheopticap-paratusandsubtotalresectionofthecystwallwasaccomp-lished . Th e patient received post-operative radiotherapyand stays symptom-free after two years . A review of theliteraturerevealedsixcasesofopticpathwayastrocytomasassociatedwithcystformation .Ourcaseappearsasthefirstcaseofanopticgliomatopresentasanintrasellarmass .
9 . PediatrNeurosurg .1996Aug;25(2):94-9 . A serial CT scan and MRI verification of diff use cereb-
rospinal gliomatosis: a case report with stereotactic di-agnosis and radiological confirmation.
OnalC,BayindirC,SiraneciR,IzgiN,YalçinI,AltinelZ,BarlasO .
Department of Neurosurgery, Istanbul University School of Medicine, Turkey.
Abstract Gliomatosiscerebri isaninfrequenttumorofneuroepit-
helial origin presenting with deterioration of cognitivefunctions, behavioral and mental changes, motor weak-ness,headache,andseizures .Laboratorydataareunconc-lusive .MRIappearstobetheimagingmodalityofchoiceand mainly reveals a bilateral and diffuse infiltration ofmidlineadjacentbrainstructureswhoseanatomicalcon-figurationremainintact .MRI-orCT-guidedstereotacticbiopsyisadvisedasthediagnosticprocedureinsuspectedcases .A9-year-oldgirlwithdiffusecerebrospinalglioma-tosis, investigated with sequential cranial CT scans, andMRI-verifiedspinalcordinvolvementisreported,andthecorrespondingliteratureisreviewed .
10 .ClinNeurolNeurosurg .1996Aug;98(3):217-21 . Subependymal giant cell astrocytoma associated with
tuberous sclerosis: diagnostic and surgical characteris-tics of five cases with unusual features.
TurgutM,AkalanN,OzgenT,RuacanS,ErbengiA . Department of Neurosurgery, Adnan Menderes University
School of Medicine, Aydin, Turkey.Abstract
Fivechildrenwithtuberoussclerosisandintracranialtu-morsweresurgicallytreatedatNeurosurgeryDepartmentof Hacettepe University School of Medicine . Two of thefivepatientspresentedwiththegiantcellastrocytomafil-ling the third ventricle . Direct surgical intervention andtumorremovalwascarriedoutinallfourpatients(threewithatotalsurgicalresectionandonewithasubtotalre-section) and cerebrospinal fluid shunting procedure inone .Histopathologicalexaminationrevealedgiantcellast-rocytomasinfourpatients .Postoperatively,onediedandtherestfourpatientssurvivedwithminorfocalneurologicdifficulties .Th esurgicalresultsandthechangingconceptsinthetreatmentoftuberoussclerosisarediscussedandtheliteratureisreviewed .
11 .JNeuroradiol .1996Jun;23(1):38-40 . Cerebral astroblastoma resembling an extra-axial neop-
lasm.
5 . TurkJPediatr .1993Apr-Jun;35(2):145-50 . Subependymal giant cell astrocytomas in tuberous scle-
rosis. OzekMM,OzekE,PamirMN,OzerAF,ErzenC . Department of Neurosurgery and Pediatrics, Marmara Uni-
versity Faculty of Medicine, Istanbul, Turkey.Abstract
Twocasesoftuberoussclerosiswithsubependymalgiantcell astrocytoma are presented . Th is rare autosomal do-minantdisorderwasalsodetected in familymembersofthepatientswhohadneverhadanysymptomsofcerebralinvolvement .Bothpatientsunderwentsurgerybecauseofsignsofincreasedintracranialpressure .
6 . ChildsNervSyst .1993Feb;9(1):39-42 . Pleomorphic xanthoastrocytoma associated with von
Recklinghausen neurofibromatosis. OzekMM,SavA,PamirMN,OzerAF,OzekE,ErzenC . Department of Neurosurgery, Marmara University Faculty
of Medicine, Istanbul, Turkey.Abstract
Th e authors present a case of pleomorphic xanthoast-rocytoma that occurred in a 14-year-old boy with vonRecklinghausen’s neurofibromatosis . Th e circumscribedtumorwithacysticcomponentwaslocatedinthemedialrighttemporallobe .Th edesignationofpleomorphicxant-hoastrocytoma has been suggested for this neoplasm onthebasisofitsuniquehistologicalfeatures .Th eseincludepositiveglialfibrillaryacidicproteinstaining .
7 . RadiatMed .1994Nov-Dec;12(6):269-72 . Intracranial ependymomas: treatment results and prog-
nostic factors. ZorluAF,AtahanIL,AkyolFH,GürkaynakM,OzyarE . Department of Radiation Oncology, Hacettepe University
Faculty of Medicine, Ankara, Turkey.Abstract
Forty-nine intracranial ependymoma patients were pos-toperativelyirradiatedwithcraniospinal,cranial,orwidelocalfields .Th irty-twopatientsreceivedanadjuvantche-motherapy regimen of vincristine and CCNU with orwithout procarbazine . Th e 10-year actuarial overall andprogression-freesurvivalrateswere57%and57%,respec-tively .Agewastheonlysignificantprognosticfactorinfa-vorofadults(p=0 .01) .
8 . JNeurosurgSci .1994Jun;38(2):137-40 . Optic nerve glioma presenting as a huge intrasellar
mass. Case report. TekkökIH,TahtaK,SaglamS . Institute of Neurological Sciences (IHT), Hacettepe Univer-
sity, Ankara, Turkey.Abstract
Wereport thecaseofa twelve-year-oldboywhopresen-tedwithvisual impairmentandheadacheandwas foundtoharbourapurelyintrasellarcysticpilocyticastrocytomaoriginating fromproximal leftopticnerve .Th emasswas
73KONU 3 Merkezi Sinir Sistemi Tümörleri
13 .ClinNeurolNeurosurg .1997May;99(2):117-23 . Managementofglioblastomamultiforme:withspecialre-
ferencetorecurrence . DurmazR,ErkenS,ArslantaşA,AtasoyMA,BalC,TelE . Department of Neurosurgery, Medical Faculty of Osmanga-
zi University, Eskişehir, Turkey.Abstract
Between 1985 and 1995, 46 patients underwent cranio-tomyforglioblastomamultiforme .Th emeanagewas47,varyingfrom9to71years .Th einfluenceofsuchprognos-ticfactorsasage,preoperativeKarnofskyscore,extentofresection,tumoursite,tumoursize,radiotherapy,reopera-tionaswellasinitialsymptomsuponsurvivalwerestudi-ed .Ofthese,grosscompleteremoval,radiotherapy,preo-perativeKarnofskyscore,andreoperationwereshowntobe statistically significant to the survival time accordingtologrankandunivariatetests .However,age,preoperativeKarnofskyscore,tumoursizeandtemporallocalisationre-mainedassignificantfactorsinmultivariateanalysis .Th eoverall median survival was 53 weeks, with no patientssurvivingmorethan3years .Of thepatients,41%survi-vedoverayearand8 .6%livedovertwoyears .Twenty-sixpatientsdevelopedarecurrentmassafteranintervalof32weeks .Th emedianintervaltimefromoperationtorecur-rencewas longer in thosepatientswhounderwentgrossremovalthaninthosewhohadasubtotalresection,28 .2against20weeks(P<0 .05) .Ofpatientswhohadarecur-rentmass,16werereoperatedon,withasubsequentme-diansurvivaltimeof26 .5weeks .Ourexperiencesuggeststhatthesurvivalofpatientswithglioblastomadependsonmanyfactors, includingradicalsurgeryasaninitialstep .Inaddition,thegrosstotalremovalofthetumouralsode-laysthedevelopmentofrecurrence .
14 .JChildNeurol .1997Feb;12(2):152-4 . Brainstem tumor with infantile spasms. AktanG,SimşekA,AysunS . Department of Pediatric Neurology, Hacettepe University,
Hacettepe Children’s Hospital, Ankara, Turkey.15 .ChildsNervSyst .1997Jan;13(1):50-6 . Anaplastic pleomorphic xanthoastrocytoma. BayindirC,BalakN,KarasuA,KasaroğluD . Department of Neurosurgery, University of Istanbul, School
of Medicine, Turkey.Abstract
A case of anaplastic pleomorphic xanthoastrocytoma(PXA)ina9-year-oldgirlisreported .Histologicalfeatu-resofPXAsarecellularpleomorphismofGFAP-positivecells,withintracytoplasmiclipidicvacuolesandareticu-lin network, bizarre giant cells, low mitotic activity, andlackofnecrosisandofendothelialvascularproliferations .Th ese tumors are generally reported to have a favorablepostoperativecourse .Inourcase,apoorclinicalprognosisandspreadof the illness throughtheCSFwasobserved .Immunohistochemicalfeaturesofthetumor,whichwere
YuntenN,ErsahinY,DemirtasE,YalmanO,SenerRN . Department of Radiology, Ege University School of Medici-
ne, Bornova, Izmir, Turkey.Abstract
Acaseofacerebralastroblastoma isdescribed inwhichMRimagingfindingssuggestedthediagnosisofanextra-axialneoplasm .Th elesionwasproventobeintracerebralbothsurgicallyandhistopathologically .Calvarialerosion,andbucklingofthecerebralcortexbyaperipherallyloca-tedwellcircumscribed,highlyenhancingmass,werethemainMRfindingsleadingtoanerrogenouspreoperativediagnosisofanextra-axialmass .Anastroblastomashouldbeincludedtothedifferentialdiagnosisofasuperficiallylocated tumor presenting with the findings of an extra-axialmass,especiallyinayoungpatient .
12 .RadiotherOncol .1997Oct;45(1):11-5 . Management of optic pathway and chiasmatic-
hypothalamic gliomas in children with radiation the-rapy.
ErkalHS,SerinM,CakmakA . Department of Radiation Oncology, Ankara University Fa-
culty of Medicine, Turkey.Abstract
BACKGROUND AND PURPOSE: Opticpathwayandchiasmatic-hypothalamicgliomasare
rarechildhoodtumors .Th isstudypresentstheexperienceinmanagementofthesetumorswithradiationtherapy .
MATERIALS AND METHODS: Th irty-threechildrenwiththediagnosisofopticpathway
and chiasmatic-hypothalamic gliomas were treated withradiationtherapyfrom1973through1994intheDepart-mentofRadiationOncologyatAnkaraUniversityFacultyof Medicine . Twenty-four children had optic pathwaygliomas and nine had chiasmatic-hypothalamic gliomas .Evidence of neurofibromatosis was present in six child-ren .Subtotalresectionwasperformedin22childrenandabiopsyinseven .Th emostcommonprescriptionfortotaltumordosewas50Gy,deliveredin2Gydailyfractions .Follow-uprangedfrom0 .5to16 .1years(mean,13 .6ye-ars) .
RESULTS: Overall,progression-freeandcause-specificsurvivalpro-
babilities for the entire group were 93%, 82% and 93%,respectively,at5yearsand79%,77%and88%,respecti-vely, at 10 years . Differences in overall, progression-freeand cause-specific survival probabilities between opticpathway and chiasmatic-hypothalamic gliomas were notstatistically significant .Absenceofevidenceofneurofib-romatosiscorrelatedwithsignificantlybetterprogression-freeandcause-specificsurvivalprobabilities .
CONCLUSION: Radiation therapy is effective in stabilization or impro-
vementofvisionandpreventionoftumorprogressioninbothopticpathwayandchiasmatic-hypothalamicgliomas .
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER74
andKaplan-MeiercurvesshowedthelevelofGST-piexp-ressionanditsnuclearlocalizationtobeinverselycorrela-tedwithpatientsurvival .Relativeriskfordeathofpatientswith high versus low tumor GST-pi expression was 3 .2(P=0 .0069)byunivariateanalysisand2 .6(P=0 .036)bymultivariateanalysis .Th erelativeriskofdeathassociatedwiththepresenceofnuclearGST-piingliomacellswas3 .9(P=0 .0001)byunivariateanalysisand4 .4(P<0 .0001)bymultivariateanalysis .Th esedataindicatethathighGST-piexpressionintumorcellsandthepresenceoftheGST-piproteinintumorcellnucleiareassociatedwithclinicallymoreaggressivegliomasandarestrongpredictorsofpoorpatientsurvival .
18 .MedPediatrOncol .1998Feb;30(2):81-4 . Subcutaneous sacrococcygeal myxopapillary epend-
ymoma. IlhanI,BerberogluS,KutluayL,MadenHA . Department of Pediatric Oncology, Ankara Oncology Hospi-
tal, Turkey.Abstract
Wereportan8-year-oldboywithaprimarysubcutaneoussacrococcygealependymoma,araretumorthatisthoughtto arise in embryologic rests . Th e lesion was completelyremoved in our patient, who has been followed withoutrecurrencefor20months .Ourexperience,togetherwiththatoftheother15casesintheworldliterature,supportssurgicalexcisionasthemainstayoftreatment .
19 .MinimInvasiveNeurosurg .1998Dec;41(4):209-13 . Radical surgery and reoperation in supratentorial ma-
lignant glial tumors. DaneyemezM,GezenF,CanakçiZ,KahramanS . Department of Neurosurgery, Gülhane Medical School, An-
kara, Turkey.Abstract
Th etreatmentmodalitiesforgliomasarestillquestioningandsearching .Wereviewedtheeffectoftheextentofsur-gicalresectionandreoperationonthelengthandqualityofsurvivalin152consecutivepatientswhounderwentope-ration for supratentorialgliomasatGATANeurosurgeryclinicbetween1985to1995 .Seventy-twopatients(50%)had glioblastoma multiforme (GBM), and 48 patients(33%) had anaplastic astrocytoma (AA) . Gross total re-sectionwasachievedin70cases(49%),subtotalresectionwasperformedin60cases(42%),andbiopsywascarriedoutin14cases(9%) .Th irty-twopatientswerereoperatedforrecurrencyandthemedianintervalbetweenthefirstoperationandreoperationwas9 .5monthsinglioblastomamultiforme, and 11 .7 months in anaplastic astrocytoma .Th eresectiongroupswerecomparedforage,sex,preope-rativeandpostoperativeKarnofskyrating,tumorlocation,postoperative radiation therapy, and chemotherapy, andsurvival according to multivariate analysis . Preoperati-veKarnofskyratingandsurgicalresectiontypewere themostimportantfactorsrelatedtosurvivalafteroperation
histologically anaplastic in nature, were analyzed . Th ereweresmallfociofnecrosisinthesectionsofthematerialobtained at the first operation and extensive necrosis inthatfromthesecondoperation,althoughthepatienthadnot received radiotherapy between the operations . Th epresenceofnecrosisinPXAisanuncommonandsigni-ficant feature . Itpredicts thepoorprognosisseen in thiscase,andthereforethisreportstronglysupportsthenotionthatnecrosisshouldautomaticallyexcludeatumorfromthePXAcategory .Th ehistologicalgradewasevaluatedasgrade3(accordingtotheWHOclassification) .
16 .ClinNeurolNeurosurg .1997May;99(2):130-4 . Cerebellar mutism: report of two unusual cases and re-
view of the literature. ErşahinY,MutluerS,SaydamS,BarçinE . Department of Neurosurgery, Ege University Faculty of Me-
dicine, Izmir, Turkey. Abstract
Mutism is not a common condition following cerebellardamage .MutismfollowingposteriorcranialfossasurgerywasfirstreportedbyRekateetal .andYonemasuin1985 .Sincethen,manycasereportsofmutismhaveappearedinthe English literature . Very few cases developed mutismfollowingbrainstemsurgery .Althoughmutismhasbeendescribed in patients with head injury, only one case ofmutismcausedbyacerebellar injuryhasbeenreported,to our knowledge . We report on two patients in whichthe cerebellar mutism following a radical excision of anexophyticbrainstemgliomaandcerebellarinjurydevelo-ped .Wereviewedtherelevantliteratureanddiscussedthemechanismofcerebellarmutism .
17 .ClinCancerRes .1997Dec;3(12Pt1):2253-61 . Prognostic significance of glutathione S-transferase pi
expression and subcellular localization in human glio-mas.
Ali-OsmanF,BrunnerJM,KutlukTM,HessK . Section of Molecular Th erapeutics, Department of Experi-
mental Pediatrics, Division of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, 77030, USA.
Abstract Th e glutathione S-transferase (GST)-pi gene is overexp-
ressedinmanyhumancancersandpreneoplastic lesionsandisassociatedwithfailureofcancerchemotherapyandpoorpatientsurvival .AlthoughGST-pioverexpressionintumorsofthecentralnervoussystemhasbeenobserved,the prognostic and/or clinical relevance of this overexp-ressionhas,todate,notbeeninvestigated .Inthisstudy,weanalyzedthelevelofGST-piexpressionanditssubcellularlocalizationin61primarygliomasandcorrelatedthere-sultswithtumorhistology,patientage,andpatientsurvi-val .WeobservedastrongpositivecorrelationbetweenthelevelofGST-piexpressionandtumorgradeandbetweenthepresenceofGST-pi ingliomacellnuclei andpatientage .UnivariateandmultivariateCox regressionanalyses
75KONU 3 Merkezi Sinir Sistemi Tümörleri
Department of Neurosurgery, Istanbul School of Medicine, University of Istanbul, Capa, Turkey.
Abstract Gliomatosis cerebri is a glial neoplastic process that is
diffusely distributed through neural structures, who-se anatomical configuration remains intact . Among themore than 19,000 cases hospitalized in Istanbul Univer-sity Istanbul School of Medicine Department of Neuro-surgery throughout the past 45 years, only 2 cases werediagnosed as gliomatosis cerebri, 1 by stereotactic ante-mortemdiagnosisandtheotherafterautopsy .Inthispa-per,theautopsy-provencaseofthisrarediseasewithco-existentneurofibromatosis--thesixthcasereportedintheliterature--ispresented .
23 .PediatrNeurosurg .1999Sep;31(3):168 . Bilateral optic nerve glioma. ErşahinY,YüntenN . Division of Pediatric Neurosurgery, Ege University Faculty
of Medicine Izmir, Turkey. 24 .ActaOncol .2000;39(1):97-100 . Intracranial ependymomas in childhood--a retrospecti-
ve review of sixty-two children. AkyüzC,EmirS,AkalanN,SöylemezoğluF,KutlukT,Bü-
yükpamukçuM . Department of Pediatric Oncology, Hacettepe University Fa-
culty of Medicine, Ankara, Turkey.Abstract
Ofthe818tumoursofthecentralnervoussystemdiagno-sedbetween1972and1991,62patients(35malesand27females) with histopathologically confirmed ependymo-masweretreatedandfollowed-upattheChildren’sHospi-talofHacettepeUniversityduringthatperiod .Th emedianagewas6years(range1-17years) .Headache,nauseaandvomitingwerethemostfrequentsymptoms;papilledemawas the most common sign in our patients . Tumour si-tes were in the posterior fossa in 47 patients and supra-tentorial in 15 patients . All patients underwent surgery .Gross-totalresectionwasperformedin27patients,sub-totalresectionin32patientsandbiopsyintheremaining3 patients . Initially, 53 patients were given postoperativeradiotherapy . Four patients did not receive radiotherapybecauseoftheiryoungage,whereasfivepatientsdiedpri-ortostartingradiotherapy .Twoslightlydifferenttypesofchemotherapyprotocolswereappliedforanaverageofoneyearin47patients .Event-freeandoverallsurvivalratesat10yearswere36%and50%,respectively .Twentychildrensufferedrelapse4to55monthsafterdiagnosis(median16months) .Relapsesweredistantin3casesandlocalin17 .Agewastheonlystatisticallysignificantprognosticfactor,patientsyoungerthan5yearsofagehavingapoorerout-come .Sex,histopathologictype,localizationofthetumo-ur,extentofsurgery,andchemotherapydidnotinfluencetheprognosisinourstudy .Becausethemajorityofrecur-renceswerelocal,betterlocaltumourcontrolisrequired .
orreoperation .Th egrosstotalresectiongrouplivedlongerthanthesubtotalresectiongroupbylifetableanalysis .Me-diansurvivalofGBMwas76weeksingrosstotalresectiongroup,and33monthsinAAgroupwithtotalresection(p<0 .001) .PreoperativeKarnofskyscoreshadastatisticallysignificant effect on the quality of life and survival afteroperationandreoperationinallcases(p=0 .005) .Radicalsurgeryandreoperationalsoimprovequalityandlengthoflifeinselectivemalignantsupratentorialgliomas .
20 .NeurosurgRev .1998;21(1):23-30 . Th e neurosurgical aspects of neurofibromatosis 2: diag-
nosis and management. TurgutM,PalaoğluS,OzcanOE . Department of Neurosurgery, Adnan Menderes University
Medical Faculty, Aydin, Turkey.Abstract
NF-2 is an extremely rare form of neurofibromatosis(NF)characterizedbycentralsystem(CNS)neuralcrest-derivedtumorsandfrequentlycafeaulaitspots(CLS) .Th epurposeofthisstudywastoreporttheclinicalandimagingfindingsofsevenpatientswiththisdisorderandtostressthatvalueofsurgicaltreatmentinitsmanagement .Sevenpatientsbetween8and32yearsofagewhohadNF-2wereincludedinthestudy .Clinicalcharts,surgicalandpatho-logical findings, and imaging studies were reviewed ret-rospectively .Patientswerefollowedupforto142months .ClinicalevaluationandneuroimagingstudiesdetectedtheclinicalcriteriaofNF-2inallpatients .Twodeathsoccur-redafter surgical intervention inour series .Noneof thepatientssufferedfromrecurrenttumorfollowingsurgery .OurresultsshowthatNF-2isanuncommonentitywhichhasagoodprognosisaftersurgicalintervention,inspiteofthepresenceofmultiplecranialand/orspinallesions .
21 .IntOphthalmol .1999;23(3):167-70 . Cerebellar astrocytoma presenting with acute esotropia
in a 5 year-old girl. Case report. DikiciK,CicikE,AkmanC,KendiroğluG,TolunH . Ophthalmology Department, Istanbul University Cerrahpa-
sa Medical School, Cerrahpasa Istanbul, Turkey.Abstract
Weencountereda5-year-oldgirlwithacuteonsetofalter-nating,comitantesotropiaintheabsenceofdiplopiaandotherneurologicfindings .Shedidnothaveanyrefractiveerrorandseenbilateralpapilledemasinfundusexamina-tion,magneticresonanceimaging(MRI)oftheheadwasperformed .Alargecerebellarastrocytomaandmoderatehydrocephalus was identified and successfully resected .Th eonsetofcomitantesotropiainachildcanbethefirstsign of a cerebellar tumor without any other neurologicsignsandsymptoms .
22 .ChildsNervSyst .1999May;15(5):219-21 . Gliomatosis cerebri with neurofibromatosis: an
autopsy-proven case. OnalC,BayindirC .
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER76
27 .PatholOncolRes .2000;6(2):118-24 . Th e distribution of extracellular matrix proteins and
CD44S expression in human astrocytomas. OzB,KarayelFA,GazioNL,OzlenF,BalciK . Istanbul University, Cerrahpasa Medical Faculty, Depart-
ment of Pathology Aksaray, Istambul, Turkey. Abstract
Aimsof the studywere:1 . toestablish theprevalenceofCD44 protein expression in human astrocytomas; 2 . tocompare the distribution of the extracellular matrix inthesetumors;3 .toinvestigatetherelationbetweenCD44,theextracellularmatrixproteinsandthehistologicalgradeofthetumor .CD44,TypeIVCollagen(ColIV),Laminin(LN), Fibronectin (FN), and Tenascin (TN) expressionweredetectedbyimmunohistochemistryinformalinfixedparaffinembeddedtissuesamplesof52astrocytictumors:35 glioblastomas (GB), 7 Anaplastic astrocytomas (AA)and10astrocytomas(A) .Th e localizationofColIVwasobserved in the basement membrane of the vessel wallsin most of the astrocytomas (88 .4%) with a similar pat-tern obtained with LN staining . 7 of 10 A (70%), 2 of 7AA(28%)and9of35GB(25 .7%)showedLNpositivity .Th erewasanegative correlationbetweenLNexpressionandtumorgrade(p=0 .03) .FNwaseitherlocalizedinthebasement membrane or showed thick multi-layered im-munoreactivityofthevesselwalls .FNexpressionwasseenin6A(60%),4AA(57%)andallof35GB(100%) .Th eFN distribution was not uniform and its staining inten-sityshoweddecreaseinGB .3A(30%),3AA(42%),27GB(77 .1%)showedTNexpressioninthevesselwallsandinsometumorcellsof19GBs .TNexpressionwaspositivelycorrelatedwiththedegreeofvascularendothelialprolife-rationinGB(p<0 .05) .Th eexpressionofCD44swasseenasplasmamembranepositivityofgliomacellsin5of10A(50%), 3 of 7AA (42 .3%) and 29 of 35 GB (82 .8%) . Th eintensity of immunoreaction was quite strong especiallynear the vessels . Th ere was a good correlation betweenTN and CD44s expression in human astrocytic tumors(p=0 .005) .NorelationshipwasobservedbetweenGFAP,ECMproteinsandCD44sexpression .BothCD44sandTNexpressionshowedincreasewithmalignancyinastrocyto-mas .Th esefindingsindicatedthatthehistologicalmalig-nancyoftheastrocytomaswascorrelatedwithexpressionofTNandCD44s .Itwassuggestedthat inastrocytomastherewasabiologicalrelationshiponlybetweenCD44andTN,butnonewiththeotherECMproteins .TNmayplayaroleinangiogenesisinhumanastrocytictumors .
28 .ChildsNervSyst .2000May;16(5):309-11 . Chiasmatic low-grade glioma presenting with sacral
intradural spinal metastasis. AkarZ,TanrioverN,KafadarAM,GaziogluN,OzB,Ku-
dayC . Department of Neurosurgery, Cerrahpaşa Medical Faculty,
Istanbul University, Turkey.
Newtreatmentstrategiesshouldbedevelopedinordertoimprovelocalcontrol .
25 .JChildNeurol .2000Nov;15(11):765-7 . Moyamoya syndrome aft er radiation therapy for optic
pathway glioma: case report. SerdaroğluA,SimşekF,GücüyenerK,OğuzA,Karadeniz
C,BalibeyM . Gazi University, Faculty of Medicine, Department of Paedi-
atrics, Ankara, Turkey. Abstract
Wepresenta4-year-oldgirlwithneurofibromatosis-1whodevelopedmoyamoyasyndromecharacterizedbybilateralstenosisorocclusionofthedistalinternalcarotidarteriesandtheirbranches,leadingtothedevelopmentofanab-normalvascularnetwork .Inlightofaliteraturereview,thepostradiationvasculopathyofthemoyamoyatypeanditsrelationshipwithneurofibromatosis-1arediscussed .
26 .JPediatrSurg .2000Mar;35(3):515-8 . Sacrococcygeal extraspinal ependymomas: the role of
coccygectomy. AktuğT,HakgüderG,SarioğluS,AkgürFM,OlgunerM,
PabuçcuoğluU . Department of Pediatric Surgery, Dokuz Eylül University,
Medical Faculty, Izmir, Turkey.Abstract
BACKGROUND: Ependymomas, the common glial tumors of the spi-
nal cord, occur occasionally outside the central nervoussystem and are called exstraspinal ependymomas (EEP) .EEPs are found primarily in sacrococcygeal region du-ringchildhood .Th epathogenesisandthetreatmentofthesacrococcygeal(SC)ependymomasarestillcontroversial .Th erefore,wepresentourcasewithmetaanalysisofothercasereportstodeterminetheoptimaltreatmentmodalityforSCEEPs .
METHODS: AmetaanalysisofcasereportsofSCEEPs,includingthe
currentcase,wasconducted .AlsoallavailablecasereportsofEEPs,withoutagelimit,wereanalyzedtodeterminethedistributionofEEPslocalization .
RESULTS: EEPsusuallyare found in teratoma localizationssuchas
the SC area, ovary, paraovarian structures, and medasti-num .Th edistributionofEEPslocalizationdifferswithage .LocalrecurrencerateofEEPsaftercoccyxexcisioniszero,however,itincreasesto71%whenthecoccyxwasleftbe-hind .
CONCLUSION: Th e identical clinical characteristics of the SC teratomas
andEEPsimplythattheSCEEPsmaybemonophasicte-ratomasastheirovariancounterpartsarenamed .Coccyxexcisionisanimportantpartofthesurgicaltreatmentofthesetumors,withanapparentdecreaseintherecurrencerate .
77KONU 3 Merkezi Sinir Sistemi Tümörleri
January1996,wereprospectivelyreviewedforthepresen-ceofrecurrenceandhistopathologicaldedifferentiationattheir fourthyearsafter the initial treatment .Twenty-twopatients underwent surgical resection . Of this group, 7patientshadatotal,11hadasubtotaland4patientshadapartialresection .Sixpatientsunderwentstereotacticbi-opsy . All patients, except for the ones in whom a radio-logicaltotalsurgicalremovalcouldbeachieved,receivedpostoperative radiotherapy . In the total surgical-removalgrouponlyonepatienthadrecurrence,whilenoupgradewasnoted .Allofthepatientsinthepartialresectionandstereotacticbiopsygroupsrecurredatahighergrade .Ourresultsindicatethatbothtumorprogressionandhistopat-hologicaldedifferentiationwerelesscommonlyseenwhenatotalorsubtotalresectioncouldbeachieved .So,surgery,asradicalaspossible,shouldbethechoiceoftreatmentinlow-gradehemisphericastrocytomas .
34 .PediatrNeurosurg .2002Sep;37(3):118-21 . An unusual tuberous sclerosis case presenting with fib-
rillary astrocytoma. ErenS,PolatP,ErmanZ . Department of Radiology, Faculty of Medicine, Atatürk Uni-
versity, Erzurum, Turkey. Abstract
Tuberoussclerosis(TS)isanautosomaldominantdisor-der . It is characterized by hamartomatous lesions in va-rious organs such as the brain, skin, kidneys and heart .Subependymal and parenchymal nodules occur in thecerebrum . Although giant cell astrocytoma may developfrom these subependymal nodules, tumor formation isveryrareinthecorticalnodules .Wepresenttheclinical,computed tomography and magnetic resonance imagingfindingsofafibrillaryastrocytomaoriginatingfromacor-ticaltuberina4-year-oldfemalewithTS .
35 .JPostgradMed .2002Apr-Jun;48(2):158-9 . Transient cerebellar mutism aft er posterior fossa sur-
gery. ArslantasA,ErhanC,EmreE,EsrefT .36 .ComputMedImagingGraph .2002May-Jun;26(3):187-91 . Astroblastoma: diff usion MRI, and proton MR spect-
roscopy. SenerRN . Department of Radiology, Ege University Hospital, Bornova,
35100 Izmir, Turkey. Abstract
ApatientwithgradeIIastroblastomaisreported .Th etu-morrevealedaninhomogenousenhancementpatternonT1-weighted images after contrast medium . It containedcyst-like structures with high signal in FLAIR images,consistentwithpresenceofviscousmaterial .Inspectros-copy,NAAwasdecreased,andChowasincreased .Peaksbelonging to lipids and a combined broad peak belon-gingtomyoinositolandglycinewerenoticed .IndiffusionMRI, themeanapparentdiffusioncoefficient(ADC)va-
Abstract Leptomeningealmetastasisoflow-gradegliomasinchild-
ren has been documented in several series, both at thetimeofdiagnosisandatrelapse .Th eauthorsreportauni-quecaseofchiasmaticlow-gradeastrocytomapresentingwithsignsandsymptomsrelatedtothemetastaticsiterat-her than the primary site . In this respect, the possibilityofappearanceofsymptomsandsignsrelatedtoleptome-ningealdisseminationprecedingthesignsandsymptomsbelongingtotheprimarysiteshouldbeconsideredinthistypeofbenigntumours .
29 .JPediatrGastroenterolNutr .2000Apr;30(4):453-7 . An uncommon and oft en overlooked cause of failure to
thrive: diencephalic syndrome. ErtemD,AcarY,AlperG,KotilogluE,PehlivanogluE . Division of Pediatric Gastroenterology and Nutrition, Mar-
mara University School of Medicine, Istanbul, Turkey.30 .ActaRadiol .2000Jul;41(4):375-6 . Chiasmatic glioblastoma of childhood. A case report. CirakB,UnalO,ArslanH,CinalA . Department of Radiology, Yuzuncu Yil University Medical
Center, Van, Turkey.Abstract
A6-year-oldgirlpresentedwithvisualdeteriorationthathadprogressivelyworsenedover2months .MRimagingrevealed a sellar, para- and suprasellar lesion . Subtotaltumor resection was performed . Histopathological diag-nosiswasglioblastomaof theoptic chiasma .Chiasmaticglioblastomaisrareinadultsandextremelyuncommoninchildren .Surgicalresectionimpliesariskofsevereendoc-rinologicandophthalmologiccomplications .
31 .PediatrInt .2000Aug;42(4):389-91 . Primary leptomeningeal astrocytoma in a child. CirakB,CaksenH,UgrasS,UnalO . Department of Neurosurgery, Yuzuncu Yil University Fa-
culty of Medicine, Van, Turkey32 .DevMedChildNeurol .2001Sep;43(9):647-8 . ‘Diff use cerebrospinal gliomatosis’. OnalC,BayindirC,IzgiN,BarlasO . Istanbul University, Istanbul, Turkey33 .JClinNeurosci .2002Sep;9(5):549-52 . Eff ect of surgery on tumor progression and malignant
degeneration in hemispheric diff use low-grade astrocy-tomas.
KiliçT,OzdumanK,ElmaciI,SavA,NecmettinPamirM . Marmara University Institute of Neurological Sciences, Is-
tanbul, Turkey.Abstract
Th eaimof this study is todetermine the impactof sur-geryontumorprogressionandmalignantdegenerationinhemisphericdiffuseastrocytomaWHOgradeII .Twenty-eight patients who were operated or underwent stereo-tactic biopsy for hemispheric diffuse astrocytoma WHOgradeIIatMarmaraUniversitybetweenJanuary1987and
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER78
andmightcontributetodifferentiatingopticgliomasfromhamartomas,andmyelinvacuolization,however, furtherstudieswillberequiredforassessingtheroleofdiffusionimaginginsuchlesions .
39 .TurkJPediatr .2003Jul-Sep;45(3):276-9 . Sacrococcygeal extraspinal ependymoma: a case report. AkpolatN,BozlakN,KazezA,KöseoğullariAA . Department of Pathology, Firat University Faculty of Medi-
cine, Elaziğ, Turkey.Abstract
Ependymomas, the common glial tumors of the spi-nal cord, occur occasionally outside the central nervoussystem and are called extraspinal ependymomas (ESE) .ESE,whichareclinicallyconfusedwithothersacrococc-ygeal tumors,arerarelyseenand foundprimarily in thesacrococcygealregionduringchildhood .Wereportacaseofaseven-year-oldboypresentingwithamidlinemass(6cmdiameter)overhiscoccyx .Th esolidmasswasdiagno-sedasmaxillopapillarytypeofependymoma .Clinicalandhistopathologicalfeaturesofthecasearedescribedandli-teraturereviewed .
40 .Neuropathology .2003Sep;23(3):214-8 . Pilocytic astrocytoma of neurohypophysis. ReísA,KuzeylíK,CobanoğluU,CakirE,UsulH,SariA . Department of Pathology, Faculty of Medicine, Karadeniz
Technical University, Trabzon, Turkey.Abstract
A case of pilocytic astrocytoma of neurohypophysis ispresented . Th e clinical, pathological and MRI featuresofararetumorof theneurohypophysisaredescribed .A5-year-old girl presented with a 3 month history of let-hargy,imbalanceandvisualdisturbances .AMRIrevealeda large suprasellar mass . Histopathological examinationdemonstratedapilocyticastrocytoma .Itsastrocyticnatu-rewasconfirmedbypositive immunostaining forGFAPandthefindingsofanelectronmicroscopy .
41 .PediatrNeurosurg .2003May;38(5):223-31 . Tectal gliomas in children: the implications for natural
history and management strategy. DağlioğluE,CataltepeO,AkalanN . Department of Neurosurgery, Hacettepe University Medical
School, Ankara, Turkey.Abstract
Tumors involving the tectal region constitute a distinctsubgroupofbrainstemgliomaswithanindolentclinicalcourse . Here, we present the clinical and neuroradiolo-gicfeaturesof9childrenwithtectaltumors .Allpatientspresentedwithsignsandsymptomsofhydrocephalusandweremanagedwithventriculoperitonealshuntinsertion .MRI studies revealed focal hyperintense lesions on T2-weightedimageswithoutanycontrastenhancement,andnoevidenceofprogressionwasdemonstratedinanypa-tient .Wealsoreviewedthepublishedseriesoftectalgli-omasintheliteraturetocomparewithourresults .Based
lueof intratumoralcyst-likestructureswas2 .12x10(-3)mm(2)/s less than that of CSF . Th e matrix of the tumorhadlowerADCvaluesrangingfrom1 .19to1 .25x10(-3)mm(2)/s,higherthanthatofnormalcerebralparenchyma .
37 .ComputMedImagingGraph .2002Jan-Feb;26(1):25-31 . Longstanding tectal tumors: proton MR spectroscopy
and diff usion MRI findings. SenerRN . Department of Radiology, Ege University Hospital, Bornova,
Izmir 35100, Turkey. Abstract
Four patients with longstanding tectal tumors are inclu-dedinthisstudy .Th etectallesioninaneurofibromatosistype1(NF1)patientwasduetoahamartoma,whileothersrepresentedgliomas .Onspectroscopy,decreasedNAApe-akswithresultantdecreasesintheNAA/Cho,andNAA/Crratioswereobservedintwopatients .Inthreepatients,ondiffusionMRIthetectaltumorswerehyperintenseonb=1000 s/mm(2) (heavily diffusion-weighted) images .Onapparentdiffusioncoefficient(ADC)maps,theyhadhigh signal, and high ADC values (mean=1 .20 x 10(-3)mm(2)/s),comparedtonormalcerebralparenchyma .Dif-fusionMRIfindingssuggestedthattectaltumorshadare-lativelyhighnucleartocytoplasmicratio(high-signalonb=1000 s/mm(2) images) in association with a relativelylooseintercellularmatrix(highADCvalues) .
38 .ComputMedImagingGraph .2002Mar-Apr;26(2):59-64 . Diff usion MRI in neurofibromatosis type 1: ADC eva-
luations of the optic pathways, and a comparison with normal individuals.
SenerRN . Department of Radiology, Ege University Hospital, Bornova,
35100, Izmir, Turkey. Abstract
In a control group of 12 normal children (ages rangingfrom9monthsto3years;mean=1 .6years)themeanap-parent diffusion coefficient (ADC) value of the normalwhitematter,obtainedfromautomaticallygeneratedADCmaps,was0 .84+/-0 .14x10(-3)mm(2)/s .Apatientwithneurofibromatosis type 1 with bilateral optic gliomas,and extensive optic pathway involvement was evaluatedbydiffusionMRI .MultiplemeasurementsofADCvaluesthroughouttheinvolvedopticradiationsrevealedahighermeanvalue:1 .16+/-0 .06x10(-3)mm(2)/sthanthatofthenormal white matter, suggesting relatively high molecu-larmotionintheseregions,probablyrepresentingmyelinvacuolization . ADC evaluation of a thalamic hamarto-marevealeda lowervalue(=1 .06x10(-3)mm(2)/s)thanthis .Th emeanADCvalueobtainedfrommultiplemea-surementsof theenlargedoptic chiasm,and intraorbitalportionsofthenervewassimilar(=0 .81+/-0 .09x10(-3)mm(2)/s) to thatof thenormal cerebralwhitematterofthecontrolcases .ItappearsthatdiffusionimagingcanbeusefulinevaluationofopticpathwayinvolvementinNF1,
79KONU 3 Merkezi Sinir Sistemi Tümörleri
CakirerS,KaraarslanE . Istanbul Sisli Etfal Hospital, Department of Radiology, Is-
tanbul, Turkey. Abstract
A patient with neurofibromatosis type I (NF1) wasfollowed-up with serial magnetic resonance imaging(MRI) studies over a period of 6 years . A contrast-enhancing lesion of the internal capsule, histologicallyproven to be pilocytic astrocytoma through stereotacticbrainbiopsywithmasseffectandassociatededema,wasdetected to reveal spontaneous involution on follow-upMRIstudies .Althoughspontaneousregressionofgliomasoftheopticpathway-hypothalamusinpatientswithNF1isrelativelycommonintheliterature,spontaneousinvolu-tionofnon-optic(i .e .areasotherthanopticpathwaysandhypothalamus) gliomas is rarely reported . Conservativemanagementwithfollow-upMRIstudiesshouldbecon-sideredfornon-opticglialtumorsandtumor-likemassesinpatientswithNF1,andsurgicaltreatmentshouldnotbeconsideredunlessthelesionsexhibitarapidorunrelentinggrowthonserialMRIstudiesorproducesignificantclini-caldeterioration .
45 .Tumori .2004Jan-Feb;90(1):157-60 . Gliofibroma: an incompletely characterized tumor. Erguvan-OnalR,AteşO,OnalC,AydinNE,KoçakA . Department of Pathology, Inönü University School of Medi-
cine, Malatya, Turkey. Abstract
Althoughgliofibromaisarareandincompletelycharacte-rizedtumor,recentpublicationshaverevealednewaspectsofthisentity .Th ecaseofa16-year-oldboywhowasdiag-nosedashavingagliofibromaispresentedhere,andtheproblemsregardingnosologyarediscussedinthelightoftherecentliterature .
46 .TurkJPediatr .2004Jan-Mar;46(1):95-7 . Pediatric cerebellar cystic oligodendroglioma: case re-
port and literature review. BayseferA,DüzB,ErdoğanE,DeveciMS . Department of Neurosurgery, Gülhane Military Medical
Academy, Ankara, Turkey.Abstract
Oligodendrogliomas rarely occur in the posterior fossa ofchildhoodandconstituteapproximately1%ofpediatricbra-intumors .Onlysixpediatricposteriorfossaoligodendrog-liomacaseshavebeen reported todateandnoneof themwerecystic .Th eauthorspresentaseven-year-oldgirlwithcystic,cerebellarmidlinelocalizedtumor .Astandardsuboc-cipitalcraniectomywasperformedandthetumorwashis-tologicallyconfirmedasoligodendroglioma .Afteroperationthepatientunderwentradiationtherapyandatonethe-yearfollow-up,norecurrenceofthetumorwasobserved .
47 .JSpinalDisordTech .2004Dec;17(6):516-21 . Surgical treatment of intramedullary spinal cord epend-
ymomas: can outcome be predicted by tumor parameters?
ontheseandotherpublishedseries,itwasconcludedthatintrinsictectalgliomasofchildhoodwithsizeslessthan2cmindiameterandwithoutanytumorextensionorcont-rastenhancementconstituteaspecificsubgroupoftectalmasseswhichrarelydisplayinvasiveclinicalbehaviorandshouldbemanagedconservatively .CSFdiversionproce-duresand long-termyearly follow-upexaminationswithMRIscansaresufficientinthesepatients .
42 .JPediatrSurg .2004Oct;39(10):1571-3 . Endoscopic management of the intranasal glioma. AgirdirBV,DerinAT,OzbilimG,OzçaglarH . Department of ENT, Akdeniz University Medical Faculty,
Antalya, Turkey.Abstract
Th eauthorsreporttheendoscopicmanagementofaboywithnasalgliomawhowasonly35daysold .Th enasalglio-maisararecongenitalnasalabnormality,whichmanifestsasamassofextracranialcerebraltissueunconnectedwiththe brain . For surgical excision, some surgeons suggestinitial craniotomy for excluding intracranial extension .Th eauthorssuccessfullyremovedtheintranasalgliomabyendoscopic surgery without craniotomy on a 35-day-oldboy . Intranasal endoscopic surgery is a less-invasive andsafeprocedureanddoesnotresultinpostoperativefacialscarringanddeformity .Th erefore, theuseofendoscopicsurgeryinplaceoflateralrhinotomyprocedureisrecom-mended .
43 .PediatrNeurosurg .2004Jul-Aug;40(4):171-81 . Anaplastic pleomorphic xanthoastrocytomas. Review
of the literature with reference to malignancy potential. TekkökIH,SavA . Mersin University School of Medicine, Mersin, Turkey.
Abstract Malignancypotentialofpleomorphicxanthoastrocytomas
(PXAs)hasratherbeenanunderestimatedreality .Wereportthecaseofa13-year-oldboywhopresentedwithsignsofincreasedintracranialpressure .Th echildhadbeenepilepticsincetheageof2 .Computedtomographyandmagneticre-sonancescansrevealedahugeleftfrontalmass .Atsurgery,asubtotalexcisionwasaccomplished .Histopathologicaldi-agnosiswasanaplasticPXA(gradeIII;WHO,2000) .Th etu-morshowedanincreasedmitoticindexandminimalendot-helialproliferation .Th epatientdied3 .5months laterdueto a fatal intracranial hemorrhage . A review of the entirePXAliteraturerevealed15well-documentedcasesofPXAwithsubsequentmalignanttransformationand11casesofprimaryanaplasticPXA .Th eprognosiswasgrimforbothsubsets of patients . Anaplastic PXAs clearly represent thetransitionbetweentheoriginalPXAconceptandlipidizedgiant-cellglioblastoma .
44 .ActaRadiol .2004Oct;45(6):669-73 . Spontaneous involution of a non-optic astrocytoma in
neurofibromatosis type I: serial magnetic resonance imaging evaluation.
BÖLÜM 2 MALİGN SOLİD TÜMÖRLER80
50 .PediatrBloodCancer .2005Sep;45(3):298-303 . Ependymal tumors in childhood. AgaogluFY,AyanI,DizdarY,KebudiR,GorgunO,Da-
rendelilerE . Department of Radiation Oncology, Istanbul University-
Istanbul Medical Faculty, 34390 Capa Istanbul, Turkey. Abstract
BACKGROUND: Ependymaltumorsareclassifiedasependymoma(benign
orlowgrade)versusanaplasticependymoma(malignantorhighgrade) .Ependymomasrepresent5-10%ofintrac-ranial neoplasm in children . In this study, demographicdata and the treatment results of pediatric patients withependymal tumors, treated inasingle institute, isrepor-ted .
PATIENTS AND METHODS: Between1989and2001,40(22M/18F)previouslyuntre-
atedpatientswithamedianageof5 .5years(3months-15years), of histologically proven ependymal tumors (ex-cept ependymoblastomas) were referred to the InstituteofOncology,UniversityofIstanbul .Th e localizationwassupratentorial in18, infratentorial in20,bothsupraandinfratentorial in twopatients .Histologic subgroupswere18ependymomas(43 .6%),and22anaplasticependymo-mas(56 .4%) .Totaltumorresectionwasperformedin20patients(50%),subtotalin18patients(45%),andbiopsyonlyin2patients(5%) .Postoperativetreatmentconsistedofregional(8patients)orcraniospinal(CSI)(9patients)radiotherapy(RT)inpatientswithependymoma;regional(7 patients) or CSI RT (14 patients) with chemotherapy(ChT)inpatientswithanaplasticependymoma;ChTonly(1patient) inpatients less than3yearsofage .Th estan-dardtechniqueforposteriorfossairradiationwasparallel-opposedlateralfieldsandtotaldosewas45-54Gy .BetweenSeptember1989andMay1991patientsreceivedregimenA, which consisted of RT followed by eight-in-one ChT,givenevery4weeksforeightcourses .PatientswhoweretreatedbetweenJune1991andJuly1994,receivedregimenB, which included two courses of postoperative “VEC”(vincristine,etoposide,cisplatin)ChT,administeredevery3weeks,followedbyRTappliedwithlowdoseconcomi-tantcisplatinusedasaradiosensitizer .Patientswithobjec-tive response to postoperative “VEC” continued to have“VEC”aftercompletionofRTforsixmorecourses .FromAugust1994on,patients received regimenC, consistingofRTandconcomitant infusionof cisplatin followedby“VCPCU” (vincristine, cyclophosphamide, procarbazine,lomustine)administeredevery4weeksforeightcourses .
RESULTS: A totalof40patientswere included in theoutcomeand
survival data . Th e 5-year overall survival (OS) rate was64 .9%, and the 5-year progression-free survival rate was50 .8% for thewhole series .Median time forprogressionor relapse was 24 .3 months and there were 19 patients
PekerS,OzgenS,OzekMM,PamirMN . Department of Neurosurgery, Neurological Sciences Institu-
te, Marmara University, Istanbul, Turkey. Abstract
OBJECTIVE: Th eaimofthisstudywastoinvestigatewhetherthetumor
parameters of spinal intramedullary ependymomas aresignificantpredictorsofclinicalpresentationandpostsur-gicaloutcome .
METHODS: Th estudyinvolved21casesofintramedullaryependymo-
mathatwereoperatedonbetween1988and2001 .Th epa-tientswere13males(62%)and8females(38%),withanagerangeof9-70years(median38years) .
RESULTS: Inmostcases (13;62%),preoperativeneurologicexami-
nationrevealedasensorimotordeficitinatleastonelimb .Complete tumor removal was achieved in all cases . Th epatientswithwidertumorshadpoorerpreoperativeneu-rologicconditionandpoorerneurologicoutcome .Tumorlength(equivalenttomyelotomylength)wasnotcorrela-tedwithpreoperativeneurologicstatus,butlongerlengthwassignificantlyassociatedwithdevelopmentofdysesthe-siapostsurgery .Incontrasttotumorlength,tumor/cordratio(ratioofthetumorwidthtothelargestcordwidthatthetumorsite)wasidentifiedasasignificantpredictorofpreoperativeneurologicstatusandoutcome .Ratiovaluesof>0 .80werecorrelatedwithpoorerpreoperativeclinicalstatusandpoorerneurologicoutcome .Neitherextentofedema(determinedfromlength[inmillimeters]ofhype-rintensityonT2-weightedimages)norpresenceofacystinthetumorwassignificantrelativetopostoperativeneu-rologicrecoveryinthesecases .
CONCLUSIONS: Th isstudydemonstratedthatthewidthofthetumorrela-
tivetothecordisthemainpredictorofneurologicpresen-tation and postoperative status . Th e length of the tumoraffectsthepostoperativedysesthesiadevelopment .
48 .TurkJPediatr .2005Jan-Mar;47(1):98-9 . Secondary glioblastoma multiforme with a new trans-
location t(3;3)(q21;q26) following treatment of acute lymphoblastic leukemia.
YarişN,ErduranE,CelepF,YavuzM,ReisA .49 .PediatrNeurosurg .2005Sep-Oct;41(5):248-52 . Spinal seeding of a pilocytic astrocytoma following
multiple subtotal resections. Zorlu F, Selek U, Akyuz C, Ozturk A, Soylemezoglu F,
AkalanN . Department of Radiation Oncology, Faculty of Medicine,
Hacettepe University, Ankara, Turkey.Abstract
Wereportthecaseofa4-year-oldgirlpresentingwithspi-nal and leptomeningeal dissemination following severalsubtotalresectionsofcerebellarpilocyticastrocytomas .
81KONU 3 Merkezi Sinir Sistemi Tümörleri
52 .DiagnIntervRadiol .2005Jun;11(2):83-6 . Primary cerebellar glioblastoma multiforme. DemirMK,HakanT,AkinciO,BerkmanZ . Departments of Radiology, Haydarpaşa Numune Training
and Research Hospital, Istanbul, Turkey. Abstract
Primary glioblastoma multiforme of cerebellar hemisp-heres in adults is a rare condition . Most of them resultfrom dedifferentiation of astrocytoma to glioblastoma .Wepresenttwocasesofunusualdenovocerebellargli-oblastomas, one of which is the giant-cell variant . Wereview their clinical behaviour with conventional MRimaging features and discuss the key findings that canleadtothecorrectdiagnosisinsightofnewMRimagingtechnologies .
53 .PediatrRadiol .2005Sep;35(9):910-3 . Coexistence of pleomorphic xanthoastrocytoma with
Sturge-Weber syndrome: MRI features. KilickesmezO,SanalHT,HaholuA,KocamazE . Department of Radiology, Diyarbakir Military Hospital, Di-
yarbakir, Turkey.Abstract
Pleomorphicxanthoastrocytomaisarare,corticallybased,partially cystic astroglial tumour with a strongly enhan-cing solid mural nodule . We report an 11-year-old boywithapleomorphicxanthoastrocytomainthecontralate-ralhemisphere to thataffectedbySturge-Weber syndro-me . Th is unique case supports the association betweenSturge-Webersyndromeandastrocytomas .PatientswithSturge-Webersyndromewhoexperienceunexpectedneu-rologicalsymptomsshouldbeevaluatedwithMRI .
54 .RadiotherOncol .2005Jan;74(1):45-8 . Postoperative radiotherapy results in primary spinal
cord astrocytomas. ZorluF,OzyigitG,GurkaynakM,SoylemezogluF,Akyol
F,LaleAtahanI . Department of Radiation Oncology, Faculty of Medicine,
Hacettepe University, 06100 Ankara, Turkey.Abstract
BACKGROUND AND PURPOSE: Weretrospectivelyevaluatedthetherapeuticoutcomesof
patients with primary spinal cord astrocytomas treatedwithconventionalradiotherapyatourinstitute .
PATIENTS AND METHODS: BetweenMay1975andDecember1997,26patientswith
histologicallyprovenspinalcordastrocytomasweretrea-ted with conventional radiotherapy, and twenty-four eli-gible patients were evaluated . Median age was 19 years(2-41years) .FourteenofastrocytomasweregradeI,6ofthemgradeIIand4gradeIII .Tenpatientshadsubtotalex-cision,and14hadonlybiopsyoftheprimarylesion .Pati-entsweretreatedwith1-2Gydailyfractions,andgiventoamediantotaldoseof49 .5Gy(range35-60Gy)externalradiotherapytoprimarytumor .
(43 .6%) with relapse or progression . Non-metastatic pa-tients(P=0 .0008,5-yearOSratewas82%vs .29%),andtotallyresectedpatients(P=0 .01,5-yearOSratewas80%vs .55%),and>or=3yearsofage(P=0 .04,5-yearOSratewas75%vs .38%)hadsignificantlybetteroutcome .
CONCLUSIONS: Th e majority of complete responders were patients who
hadtotaltumorremoval .Treatmentfailureoccurredma-inlywithinthefirst2years,andoutcomewasdismalforpatientswhorelapsedorhadprogressivedisease .Th eme-dianageatdiagnosisis6yearsinourpatientgroup;yo-ungerchildren(lessthan3yearsold)havelessfavorableoutcome .Th erewasnosignificantdifference insurvivalor progression-free survival between the two histologicsubtypes .
51 .JNeurooncol .2005Nov;75(2):189-93 . Postoperative radiotherapy and chemotherapy in the
management of oligodendroglioma: single institutional review of 88 patients.
OzyigitG,OnalC,GurkaynakM,SoylemezogluF,ZorluF . Department of Radiation Oncology, Faculty of Medicine,
Hacettepe University, 06100 Ankara, Turkey. Abstract
We retrospectively evaluate the prognostic factors af-fecting the local control, survival and the potential roleof chemotherapy in the management of patients witholigodendroglioma . Th e medical records of 88 patientstreatedbypostoperativeexternalbeamradiotherapy+/-chemotherapyatourinstitutionbetweenDecember1993andDecember2002wereanalyzed .Ninepatients(10%)were treated with an accelerated fractionation scheme,while 79 patients were treated with conventional doses .Th emedianRTdosewas54 .8+/-2 .58Gyforlow-gradetumors,and58 .7+/-2 .46Gyforhigh-gradetumors .PCVchemotherapyregimenwasgivento18patients;temozo-lamidewasadministeredinthreepatients .Chemotherapywasnotgivenconcomitantly inanypatients .Th emedi-anfollow-upwas56months(range7-134months) .Th e5-yearoverallandprogression-freesurvivalratesforen-tiregroupwere86%and79%,respectively .Patientswithepilepsyatpresentationhadbetter5-yearoverallsurvival(93% vs . 74%, P=0 .04) . High grade tumors had signifi-cantly lower overall survival rate . Age, presence of mo-tordeficitatdiagnosisandhistologicalgradewerefoundhave a significant impact on progression-free survival .Th e5-yearoverallandprogression freesurvivalratesofpatientswithhigh-gradetumorswere69%,51%and74%,68%forchemotherapyandno-chemotherapygroup,res-pectively (P=0 .9 forOS,P=0 .3 forPFS) . Inmultivariateanalysisnosignificantfactoraffectingtheoverallsurvivalandprogression-freesurvivalwasfound .Chemotherapygiven after postoperative radiotherapy in patients witholigodendrogliomadidnot improvesurvival in this ret-rospectivestudy .
337
1953-2011yıllarıarasındatoplam447adetlösemikonuluyayıntespitedilmiştir .Lösemialtgruplarınabakıldığındaensıkakutlenfoblastiklösemikonusundayayınolduğugörülmüştür(TabloI) .Lösemiyayınlarının190adediderleme,özgünaraştırmaveseriçalışmaşeklindeolup,257adedieditöremektupveolgusunumlarındanoluşmaktadır .
TABLO 1. Lösemi alt grup dağılımı
LÖSEMİ TİPİ YAYIN SAYISI
Akut Lenfoblastik Lösemi 228
Akut Miyeloid Lösemi 117
Bifenotipik Lösemi 4
Kronik Lösemiler 23
Karışık lösemi grupları 75
TOPLAM 445
TABLO 2. İlk isim en çok yayını olan ilk 10 yazar
YAZAR ADI YAYIN SAYISIGönül Hiçsönmez 36
Sevgi Yetgin 19
Ayhan Çavdar 14
Şinasi Özsoylu 14
Lale Olcay 9
Şule Ünal 8
Erol Erduran 7
Murat Tuncer 7
Mustafa Büyükavcı 6
Barış Malbora 6
Emel Özyürek 6
TABLO 3. Yazar sırasına bakılmaksızın en çok yayını olan ilk 10 yazarYAZAR ADI YAYIN SAYISIGönül Hiçsönmez 65
Murat Tuncer 63
Mualla Çetin 54
Sevgi Yetgin 52
Şinasi Özsoylu 35
Fatma Gümrük 32
Aytemiz Gürgey 32
Namık Özbek 31
Sevgi Gözdaşoğlu 19
Lale Olcay 19
TABLO 4. En çok yayını olan kurumlar
KURUM SAYIHacettepe Üniversitesi 154
İstanbul Üniversitesi 47
Ankara Üniversitesi 29
Başkent Üniversitesi 20
Dokuz Eylül Üniversitesi 14
Dr. Sami Ulus EAH 12
Ege Üniversitesi 12
Çukurova Üniversitesi 12
Erciyes Üniversitesi 11
Gazi Üniversitesi 11
15 Lösemiler
BÖLÜM 3 HEMATOLOJİK MALİGNİTELER338
TABLO 5. En çok sitasyon alan ilk 10 yayın
YAZAR ADI KURUM YIL YAYIN ADI DERGİ ADIÇALIŞMA TİPİ
SİTASYON SAYISI
Cetin MHacettepe Uni
2005The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease
BloodÖzgün araştırma
83
Senturker SOsmangazi Uni
1997Oxidative DNA base damage and antioxidant enzyme levels in childhood acute lymphoblastic leukemia
FEBS LettÖzgün araştırma
60
Cavdar AO Ankara Uni 1989
High risk subgroup of acute myelomonocytic leukemia (AMML) with orbito-ocular granulocytic sarcoma (OOGS) in Turkish children. Retrospective analysis of clinical, hematological, ultrastructural and therapeutical fi ndings of thirty-three OOGS
Acta Haematol
Seri çalışma 51
Balta G Hacettepe Uni
2003Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia
Am J Hematol
Özgün araştırma
48
Buyukavci M Ataturk Uni 2006Melatonin cytotoxicity in human leukemia cells: relation with its pro-oxidant eff ect
Fundam Clin Pharmacol
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33
Hicsonmez GHacettepe Uni
1991
Diff erentiation of myeloid leukemic cells induced by high-dose methylprednisolone in patients with acute myeloblastic leukemia and its therapeutic potential
Leuk Res Derleme 31
Ozgen U Inonu uni 2000
Comparison of DiOC(6)(3) uptake and annexin V labeling for quantifi cation of apoptosis in leukemia cells and non-malignant T lymphocytes from children
CytometryÖzgün araştırma
30
Hicsonmez GHacettepe Uni
1991
Acceleration of leukocyte recovery by administration of short-course high-dose methylprednisolone in children with acute lymphoblastic leukemia
Pediatr Hematol Oncol
Editöre mektup
30
Ekmekci CGIstanbul Uni
2004Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia
Am J Hematol
Özgün araştırma
29
Tuncer AM Hacettepe Uni 1992
The eff ect of high-dose methylprednisolone treatment on GM-CSF level in children with acute leukemia: a pilot study Leuk Res
Özgün araştırma 28
Hicsonmez G Hacettepe Uni 1996
Morphologic evidence of apoptosis in childhood acute myeloblastic leukemia treated with high-dose methylprednisolone
Leuk Lymphoma Vaka takdimi 28
339KONU 15 Lösemiler
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BerkelI,SayB,TinaztepeB . Ankara University, Ankara, Turkey2 . TurkJPediatr .1970Jan-Apr;12(1):24-33 . Acute leucemia in a patient with juvenile rheumatoid
arthritis displaying cystic osseous lesions. SaatçiU,PirnarT . Hacettepe University, Ankara, Turkey3 . Cancer .1975Oct;36(4):1444-9 . Burkitt’s lymphoma cell leukemia in a Turish boy. CehreliC,TosunN . GATA, Ankara, Turkey
Abstract Burkitt’slymphoma,associatedwithmassivebonemarrow
andeyelidinvolvementthatterminatedwithamanifestedleukemicpicture,wasobservedinaTurkishboy .ReviewoftheworldliteraturerevealedthefactthatBurkitt’slym-phomawithafranklyleukemicpictureisararecondition,andusuallyhasaveryacutecoursewithapoorprognosis .
4 . ActaHaematol .1977;57(3):188-92 . Burkitt’s lymphoma cell leukemia. AcarS,TekinalpG,OzsoyluS,CevikN,YaşarH . Hacettepe University, Ankara, Turkey5 . BollIstSieroterMilan .1977Nov30;56(5):449-56 . E-rosette forming lymphocytes in acute leukemia before
and aft er cell incubation with human serum thymic fac-tor.
OzgerTopuzU,OkçuogluCavdarA,AstaldiG . Ankara University, Ankara, Turkey
Abstract Th eAuthorsstudiedtheeffectofthehumanserumthymic
factor on the peripheral blood leukocytes from ALL pa-tients,by testing the frequencyof theE+cellsbymeansoftheErosetteassaybeforeandaftercellincubationwiththisfactor .Infouroutoftwenty-fourpatientstested,thethymic factor incubation of peripheral blood mononu-clears increased the number of E+ cells . Th e shift fromE-toE+cellscausedbythehumanserumthymicfactoroccurredamongnullcells(E-,SM-Ig-) .Th epossiblevalueof the test in investigatingwhetheraT0 leukemiamightreallyexists ispointedout,aswellas itsprospective im-portanceinmonitoringthevariationsoftheimmatureTcellcountsinrelationshiptothepatient’streatmentandhisdiseasecourse .
6 . MinervaMed .1978Apr14;69(18):1275-80 . Use of thymus hormone in the demonstration of acute
T-null cell lymphocytic leukemia].
OzgerTopuzU,AstaldiG,CavdarA . Ankara University, Ankara, Turkey
Abstract Th eAuthorsstudiedtheeffectofthehumanserumthymic
factor on the peripheral-blood leukocytes from ALL pa-tients,bytestingthefrequencyoftheE+cellsbymeansoftheerosetteassaybeforeandaftercellincubationwiththeabovementionedfactor .In3outof24patientstested,thethymic factor incubation of peripheral-blood mononu-clears increasedthenumberofE+cells .Th eshift fromRtoE+cellscausedbythehumanserumthymicfactoroc-curredamongnull cells (E-,SM-Ig-) .Th epossiblevalueof the test in investigatingwhetheraT0 leukemiamightreallyexists ispointedout,aswellas itsprospective im-portanceinmonitoringthevariationsoftheimmatureTcellcountsinrelationshiptothepatient’streatmentandhisdiseasecourse .
7 . BiblHaematol .1978;45:152-5 . Human serum thymic factor in detecting acute T cell
leukemia. OzgerTopuzU,CavdarAO,AstaldiG . Ankara University, Ankara, Turkey
Abstract Inacuteleukemia,thefrequencyoftheE+cellsamongthe
bloodmononuclearsbeforeandaftertheirincubationwithhumanserumthymicfactorwasinvestigatedbymeansoftheErosetteassay .In4of24patients tested, thethymicfactorincubationoftheirperipheralbloodcellsincreasedthe number of the E+ cells among the mononuclears .Prospective importanceof thetesteither in investigatingwhetheraT0leukemiamightreallyexist,orinmonitoringpossiblevariationsoftheimmatureTcellcountsinrela-tionshiptothepatient’streatmentandhisdiseasecourse,arediscussed .
8 . TurkJPediatr .1979Jan;21(1):24-7 . Acute lymphoblastic leukemia and toxoplasmosis. HiçsönmezG,KanraG,GürselT,YetkinS,AltintaşK .9 . JPediatr .1980Jan;96(1):166-7 . Idiopathic thrombocytopenic purpura with acute leuke-
mia. OzsoyluS . Hacettepe University, Ankara, Turkey10 .TurkJPediatr .1982Jul-Sep;24(3):159-67 . Prognosis in 262 Turkish children with acute lym-
phocytic leukemia. HiçsönmezG,OzsoyluS,YetginS,ZamaniV,GürgeyA,
AtahanI . Hacettepe University, Ankara, Turkey11 .AmJDisChild .1982Dec;136(12):1098-9 . Poland’s syndrome and leukemia.
a. Akut Lenfoblastik Lösemiler
BÖLÜM 3 HEMATOLOJİK MALİGNİTELER340
YetginS,Zamani-ProzorovaV,HiçsönmezG . Hacettepe University, Ankara, Turkey19 .AmJDisChild .1986Jun;140(6):503-4 . Pickwickian syndrome related to central nervous sys-
tem leukemia. OzsoyluS,HiçsönmezG . Hacettepe University, Ankara, Turkey20 .Blood .1986Jul;68(1):322-3 . Serum lactic dehydrogenase isoenzyme pattern in child-
hood lymphoblastic leukemia. HiçsönmezG,CağlarK,RendaN . Hacettepe University, Ankara, Turkey21 .ActaHaematol .1988;80(4):224 . Acute lymphoblastic leukemia and Sweet’s syndrome. TuncerAM . Hacettepe University, Ankara, Turkey22 .IntJPediatrOtorhinolaryngol .1989Jul;17(3):281-6 . Extramedullary leukemia with central facial palsy origi-
nated from poorly diff erentiated abdominal lymphoma. KilinçY,CetikF,TanyeliA,OzşahinogluC,KumiM . Department of Pediatric Hematology, University of Cuku-
rova, Faculty of Medicine, Adana, Turkey.Abstract
An8-year-oldboywaspresentedwithcentralfacialpalsycausedbyextramedullaryleukemiawhichhadoriginatedfrompoorlydifferentiatedabdominallymphoma .Oncer-ebral tomographic scanning, there were adherences inthebasalareaof thebrain .Th eoccurrenceofcentral fa-cialpalsyisveryrareinchildhoodleukemia .However,inthiscasefacialpalsywascentralintypeandappearedasthepresentingsign .Th eoccurrenceofcentralfacialpalsywasconfirmedbytheabsenceofclinical,radiologicalandaudiologicalsignsofperipheralinvolvement .Th econtral-ateral stapediusreflex test (500,1000,and2000Hz)waspresentinthiscase .
23 .PaediatrIndones .1989May-Jun;29(5-6):112-5 . Cerebrospinal fl uid lactic dehydrogenase activity in
children with acute lymphoblastic leukemia treated for cranial prophylaxis.
CaglarMK,HicsonmezG,RendaN . Hacettepe University, Ankara, Turkey
Abstract Totallacticdehydrogenase(TLDH)activityincerebrospi-
nalfluid(CSF)hasbeenprospectivelystudiedinordertodeterminewhether itcouldbeabiochemicalmarker forbraindamageduetocranialprophylaxisinchildrenwithacute lymphoblastic leukemia (ALL) . TLDH activity hasbeen measured in 15 patients before prophylaxis, in 15patients after the prophylaxis which consisted of cranialradiotherapy (2400 rads) and intrathecal methotrexate(0 .5mg/kg-dose,5doses),in8patientsafterradiotherapyalone(2400rads)andin9patientsafterintrathecalmeth-otrexate(0 .5mg/kg-dose,5doses)alone .TLDHactivityinCSFofcombinedprophylaxisgrouphasbeenfoundtobe
HicsönmezG,OzsoyluS . HacettepeUniversity,Ankara,Turkey12 .TurkJPediatr .1983Jul-Sep;25(3):167-74 . Paraplegia aft er intrathecal administration of meth-
otrexate. UlukutluL,YildizI,UğurS,KeskinS . Istanbul University, Istanbul, Turkey13 .TurkJPediatr .1983Oct-Dec;25(4):233-43 . Changes in serum elements of childhood acute lym-
phoblastic leukemia before and during therapy. OsmanS,GürgeyA,ZamaniVP,AltayC . Hacettepe University, Ankara, Turkey14 .BrMedJ(ClinResEd) .1983Apr30;286(6375):1437 . Poor prognosis of childhood acute lymphoblastic leu-
kaemia. HicsönmezG,OzsoyluS,YetginS,ZamaniV,GurgeyA . HacettepeUniversity,Ankara,Turkey15 .TurkJPediatr .1985Oct-Dec;27(4):219-23 . Isolated splenomegaly during remission in childhood
acute lymphoblastic leukemia. OzsoyluS,HiçsönmezG,KoçakN,ZamaniVP . HacettepeUniversity,Ankara,Turkey16 .ScandJHaematol .1985Mar;34(3):256-60 . Prognostic value of the determination of serum lac-
tic dehydrogenase and its isoenzymes in children with acute lymphoblastic leukaemia.
HiçsönmezG,CaglarK,RendaN . Hacettepe University, Ankara, Turkey
Abstract Serumtotallacticdehydrogenase(LDH)levelshavebeen
foundtobesignificantlyhigherin21childrenwithacutelymphoblastic leukaemia (ALL) at initial diagnosis thanthe values of 12 children who achieved remission . Th emeanvalueofserumLDHlevelsinpatientswithhigh-riskfactorswas2347+/-1490U/ml (range430-5460U/ml),while in patients at standard risk it was 652 +/- 385 U/ml(range110-1320U/ml) .Th eserumLDHvalueswereabove 1320 U/ml in 70% of the 13 children with high-riskfactors .Th eserumisoenzymepatternswereanalyzedin17of thesechildrenat the initialdiagnosis .AlthoughLDH-3andLDH-2wereprominentatthetimeofdiagno-sis;LDH-2andLDH-1werethepredominantisoenzymesinremission .Th ehighestconcentrationsofLDH-3wereobservedinthehigh-riskgroupatdiagnosisandtheratioofLDH-3toLDH-2exceeding1 .0wasfoundinchildrenwhohadhigh-riskfactors,butnot inanypatients inthestandardriskgroup .
17 .TurkJPediatr .1986Apr-Jun;28(2):111-4 . Histocompatibility antigens (HLA) in acute lym-
phocytic leukemia. UlukutluL,YaziciH,CamH,EsenE,OzbakirF . Istanbul University, Istanbul, Turkey18 .TurkJPediatr .1986Jan-Mar;28(1):73-5 . Hypocalcemic tetany in a child with acute leukemia.
341KONU 15 Lösemiler
wasattributedtotheoncogeniceffectofradiation .29 .PediatrHematolOncol .1994Mar-Apr;11(2):227-9 . Acute lymphoblastic leukemia associated with Klinefel-
ter syndrome. GürgeyA,KaraA,TuncerM,AlikaşifoğluM,TunçbilekE . Department of Pediatric Hematology, Hacettepe University
Hospital, Ankara, Turkey.30 .JMed .1994;25(3-4):219-29 . Hyperglycemia, ketoacidosis and other complications
of L-asparaginase in children with acute lymphoblastic leukemia.
CetinM,YetginS,KaraA,TuncerAM,GünayM,GümrükF,GürgeyA .
Department of Pediatric Hematology, Hacettepe University, Ankara, Turkey.
Abstract WeshowEscherichiacoliderivedL-asparaginasecompli-
cationsobservedin14of136acutelymphoblasticleuke-miapatientsduringremissioninductiontherapyaccord-ingtoSt . JudeChildren’sHospitalTotalXIProtocol .Weobservedhyperglycemiainsixpatients;twoofthemhadaccompanyingketoacidosis .Oneofthecaseswithketoaci-dosishadperitonitisandpancreatitis .Centralnervoussys-tem symptoms such as convulsions and depression withpersonalitychanges(inonecase)wereobservedinfourofthesesixhyperglycemicpatients .Intracranialbleedingandischemic infarction were shown in cranial computed to-mographiesintwocases .Hypersensitivityreactionswereobserved in seven patients . Patients were randomly as-signedintotwogroupsandtreatedwithconventionaldosesteroids or high dose methylprednisolone . Although thefrequencyofhypersensitivityreactionswerelowerinthehighdosemethylprednisolonegroup,onepatient in thisgrouphadananaphylactic reaction .Th esefindingsonceagain high-light L-asparaginase complications which arenotdosedependentandcanbelifethreatening .
31 .AmJHematol .1994Jan;45(1):94 . Acute lymphoblastic leukemia in Fanconi’s anemia. YetginS,TuncerM,GülerE,DuruF,AliKasifoluM . Department of Pediatric Hematology, Hacettepe University
Hospital, Ankara, Turkey.32 .MedPediatrOncol .1994;22(1):68-9 . High-dose methylprednisolone in resistant and re-
lapsed children with acute lymphoblastic leukemia. HicsönmezG,OzsoyluS,OnatN,ProzorovaZV,Gümrük
F,TuncerM . Department of Pediatric Hematology, Hacettepe University
Hospital, Ankara, Turkey.33 .HematolPathol .1994;8(4):169-75 . Th e eff ect of high-dose methylprednisolone combined
chemotherapy on CD34-positive cells in acute lymphob-lastic leukemia.
TuncerAM,HiçsönmezG,GümrükF,AlbayrakD,DuruF,GüzelE,SayliT .
higherthantheonesbeforestudy(plessthan0 .05) .Th erewereinsignificantelevationsofTLDHactivityintheothertwogroups(pgreaterthan0 .05;pgreaterthan0 .05) .Th isresult indicatedcombinedcranialprophylaxisseemedtobemoretoxicthantheotherprophylaxisregimenswhentheywereusedalone .
24 .TurkJPediatr .1990Jan-Mar;32(1):39-41 . Acute lymphoblastic leukemia in a child with hemo-
globins S and Q-Iran. GürgeyA,OzsoyluS,HiçsönmezG,IrkenG,AltayC . Department of Pediatrics, Hacettepe University Faculty of
Medicine, Ankara.Abstract
A 13-year-old girl with acute lymphoblastic leukemia ispresented . Th e peripheral smear showed, in addition tolymphoblasts, marked anisocytosis, poikilocytosis, andpolychromasia .Invitrosicklingtestwaspositive .Hemo-globinelectrophoresisatpH9 .0onstarchgelrevealedthepresenceofhemoglobinA,hemoglobinS,andabandwithamobilityofhemoglobinA2 .StructuralanalysisrevealedthepresenceofhemoglobinSandanalpha-chainvariant,hemoglobin Q-Iran . Th e patient attained remission withtheinitialtherapyadministeredbutarelapseoccurredfivemonthslater .Ourstudyindicatestheneedfordetailedin-vestigationofleukemiapatientsinwhichabnormalhemo-globinsareprevalent .
25 .ActaPaediatrScand .1991May;80(5):553-4 . Priapism in a child with acute lymphoblastic leukemia. YildizI,OzşahinH,OzbekS . Department of Pediatric Hematology-Oncology, Istanbul
University, Cerrahpaşa Medical School, Turkey.26 .PediatrHematolOncol .1991Oct-Dec;8(4):367-8 . High-dose methylprednisolone for the treatment of pri-
apism in childhood leukemia. Gumruk F, Hiçsónmez G, Ozsoylu S, Gurgey A, Tuncer
AM . Hacettepe University Faculty of Medicine, Ankara.27 .PediatrHematolOncol .1991Apr-Jun;8(2):193-7 . Acceleration of leukocyte recovery by administration of
short-course high-dose methylprednisolone in children with acute lymphoblastic leukemia.
Hiçsönmez G, Onat N, Albayrak D, Yetgin S, Ozsoylu S. HacettepeUniversityFacultyofMedicine,Ankara .28 .ActaPaediatr .1993Mar;82(3):327-8 . Acute lymphoblastic leukemia following optic glioma
treated by radiotherapy and surgery. SayliT,CemerogluAP,TuncerAM,GürgeyA . Department of Pediatric Hematology, Hacettepe University
Hospital, Ankara, Turkey.Abstract
A 14-year-old girl was diagnosed as having acute lym-phoblasticleukemiafollowing5000cGycranialradiother-apyfortreatmentofopticglioma .Intheabsenceofunder-lyingpredisposingfactors,developmentofacuteleukemia
BÖLÜM 3 HEMATOLOJİK MALİGNİTELER342
35 .BloodCells .1994;20(2-3):267-73;discussion273-4 . Erythrocyte-depleted allogeneic human umbilical cord
blood transplantation. PahwaRN,FleischerA,ShihS,UckanD,DurhamS,Garo-
faloP,KarayalcinG,ShendeA,RednerA,PaleyC,etal . Department of Pediatrics, Schneider Children’s Hospital of
Long Island Jewish Medical Center, New Hyde Park, New York 11042, USA.
Abstract Cordbloodisarecentlyrecognizedsourceofhematopoietic
stemcells . It canbeemployedsuccessfully to reconstitutehematopoiesis following allogeneic transplantation . Onecurrent drawback of cord blood as a treatment has beena risk of transfusion reactions attributable to ABO bloodgroupmismatch .Removalofredcellsfromthecordbloodhas led to reduction of the stem cells by 30-50% . In thispaper we report red cell depletion by a method that em-ploys 3% gelatin to effectively sediment the erythrocytesandselectivelydepleteredcellsbutpermits94%recoveryofnucleatedcellsandenrichmentofcolony-formingcellsby granulocyte-macrophage colony-forming units, eryth-rocyteburst-formingunits, andgranulocyte-macrophage-megakaryocyte colony-forming units in the cord bloodpreparation .Th istechniquehasbeenemployedinourstudytoremoveredcellsfromthecordbloodofamaleinfantde-liveredbycesareansection,whichhaspermittedtreatmentofa female siblingsuffering from leukemia .Th erecipientwas8yearsoldandweighted36 .7/kg .CompleteHLAiden-titybetweenthetwosiblingswasestablished .Acordbloodcell transplant of cryopreserved and later thawed cells (4x10(7)nucleatedcellsperkilogram)wasadministeredtothepatientafterintensivemyeloablativechemotherapy .Th epatientexhibitedaprompthematologicrecovery(absoluteneutrophilcount>500byday31,100%malecellsinbonemarrow and peripheral blood by day 25) and has experi-enceda13-monthdisease-freesurvivaltodate .
36 .PediatrHematolOncol .1995Jul-Aug;12(4):403-5 . A case of mucoepidermoid carcinoma of the parotid
gland developing in a child aft er the treatment of acute lymphoblastic leukemia.
AtahanIL,AyhanA,OzyarE,ErtoyD,GürkaynakM . Department of Radiation Oncology, Hacettepe University
Hospital, Ankara, Turkey37 .TurkJPediatr .1996Apr-Jun;38(2):227-9 . Spontaneous complete remission in a child with acute
lymphoblastic leukemia. YetginS,TuncerAM,GülerE,OzbekN . Department of Pediatrics Hacettepe University Faculty of
Medicine, Ankara.Abstract
Afive-year-oldgirlwasadmittedtothehospitalwithfe-verandtenderlymphadenopathy .Shewasdiagnosedwithacute lymphoblastic leukemia (ALL-L3) . Because of in-fectionshewasgivenantibioticsandabloodtransfusion .
University of Hacettepe, Hacettepe Children’s Hospital, De-partment of Pediatric Hematology, Ankara, Turkey.
Abstract Th eexpressionofCD34antigenonthesurfaceofbone
marrowcellsduringremissioninductionwasstudiedin27selectedacutelymphoblasticleukemia(ALL)patientswhowereCD34negativeatpresentationandwerestrati-fiedtoreceivehigh-dosemethylprednisolone(30mg/kg/day po) or conventional-dose prednisolone (2 mg/kg/daypo) .PatientsreceivedeitherinductionwithL-Aspar-aginase, vincristine (VCR), and high-dose methylpred-nisolone[HDMP,30mg/kg/daypofor1week,20mg/kg/daypofor1week,and20mg/kg/daypoeveryotherdayfor 2 more weeks (20 patients)], or identical inductioninwhichHDMPwasreplacedbyprednisolone2mg/kg/daybymouthfor4weeks(8patients) .Bonemarrowcellsfromallpatientswerestudied1,2,and4weeksafterini-tiationof treatmentforexpressionof theCD34antigenusing a three-step indirect immunoperoxidase stainingtechnique . In the 20 patients with ALL who receivedHDMPthepercentageofnormalbonemarrowcellsex-pressing CD34 was significantly higher (p < 0 .05) thaninthe8patientswhodidnotreceiveHDMP .Th emeanpercentage of CD34-positive bone marrow cells duringthefourthweekwas17 .2%inpatientswithALLwhore-ceived HDMP, whereas patients who received 2 mg/kgprednisolone per day had only 6 .1% CD34 cells in themarrow .Absolutepolymorphonuclearleukocyte(pmnl)count was also significantly higher in the patients whoreceivedHDMPinthesecondandthirdweekoftherapy[(absolute pmnl count was 2197 .7/mm3 in the secondweek and 4091 .8/mm3 in the fourth week in the pa-tientswhoreceivedHDMPcomparedto974 .4/mm3and1556 .5/mm3inthepatientswhodidnotreceiveHDMP)(p<0 .05)] .
34 .BrainDev .1994May-Jun;16(3):246-8 . Acute ascending myelitis and encephalopathy aft er in-
trathecal cytosine arabinoside and methotrexate in an adolescent boy with acute lymphoblastic leukemia.
OzönA,TopaloğluH,CilaA,GünayM,CetinM . Department of Pediatrics, Hacettepe University Children’s
Hospital, Ankara, Turkey.Abstract
A14-year-oldboywithacutelymphoblasticleukemiade-velopedacuteascendingmyelitisfollowedbyencephalop-athy after intrathecal administration of methotrexate 15mgandcytosinearabinoside50mg .Th epatienthadnoneoftheriskfactorsnotedpreviouslyinotherpatientswithintrathecaltherapy(IT)inducedneurotoxicity .Th edosesadministeredwerewithinthestandardscales,andtoxicitydevelopedinthesecondboostofIT20daysafterthefirstone .Th eremaynotbeanyparameterstopredicttheoc-currenceofsuchsevereandrareformofCNSneurotoxic-ityattributedtoIT .
343KONU 15 Lösemiler
withprolongedbonemarrowdepression .Despite,coexist-enceofallthesechemotherapyrelatedcomplications,herneurologicfunctionsandmultipleorganfailureimprovedgradually .Aftera70days’periodofinterruption,chemo-therapywasresumedandcontinuedwithoutanyfurthercomplications .Although,theetiologyofherextensivesen-sitivitytosomedrugsremainsunclear,webelievethatitisimportanttodocumenttheseunusualeventsinthischild .
40 .EurJHaematol .1997Jan;58(1):26-31 . High-dose methylprednisolone for children with acute
lymphoblastic leukemia and unfavorable presenting features.
HiçsönmezG,GümrükF,ZamaniPV,TuncerMA,YetginS,GürgeyA,AtahanL,OzsoyluS .
Department of Pediatric Hematology, Ihsan Dogramaci Children’s Hospital, Ankara, Turkey.
Abstract In an attempt to improve treatment outcome high-dose
methylprednisolone (HDMP, 20-30 mg/kg, once a dayorally)wasusedinsteadofaconventionaldoseofsteroid(2 mg/kg/d, in 3 divided doses) in children with acutelymphoblasticleukemia(ALL)withincreasedriskfactors .HDMPcombinedwithcytotoxicagents(vincristineandL-asparaginase)resultedinanimprovedcompleteremissionrate(94%)in48newlydiagnosedchildrenwithALLcom-paredto81%in86historicalcontrolsreceivingstandarddosesteroidcombinedwiththesametreatmentregimen .Th ebonemarrowrelapseratewaslowerinpatientswhoreceivedHDMP(31%)thanincontrols(56%) .Treatmentwasdiscontinuedin56%of48patientsreceivingHDMPandin35%of86controls .Th edifferencewassignificant(p<0 .05) .Th e5-yrcontinuouscompleteremissionratewassignificantlygreaterinpatientsreceivedHDMPcomparedwiththecontrolpatients(60%vs .43%,p<0 .05) .HDMPtreatment was well tolerated without significant adverseeffects .Moreover,during inductiontherapythedurationof leukopenia(<2x10(9)/L)wasshorter inpatientsre-ceivingHDMP .WeconcludethatHDMPcombinedwithotherantileukemicagentsincreasedtheCRrateandpro-longed the duration of remission in children with ALLwhohadincreasedriskfactors .However,theoptimaldos-ageofHDMPanditsroleinmaintenancetherapyshouldbedeterminedinfuture,randomizedstudies .
41 .PediatrHematolOncol .1997Sep-Oct;14(5):491-3 . Late relapse in a patient with acute lymphoblastic leuke-
mia thirteen years aft er diagnosis. AydogduI,TayfunE,OzcanC,HarputluogluM,OzenS,
HiçsönmezG . Inonu University, Malatya, Turkey42 .FEBSLett .1997Oct27;416(3):286-90 . Oxidative DNA base damage and antioxidant enzyme
levels in childhood acute lymphoblastic leukemia. SentürkerS,KarahalilB,InalM,YilmazH,Müslümanoglu
H,GedikogluG,DizdarogluM .
Herbonemarrowwasinremissionafter15dayswithoutchemotherapy .Th iscaseemphasestheroleoftransfusionand/orinfectioninobtainingcompleteremissionwithoutchemotherapy .
38 .ChildsNervSyst .1997Oct;13(10):560-2 . Assessment of brain perfusion by 99mTc-HMPAO
SPECT in akinetic mutism due to high-dose intrave-nous methotrexate therapy.
KarabacakNI,OzturkG,GucuyenerK,GokcoraN,GurselT .
Department of Nuclear Medicine, Gazi University Medical School, Ankara, Turkey.
Abstract Chemotherapy of the central nervous system may cause
neurotoxicity in children with acute lymphocytic leuke-mia . We evaluated regional blood flow in a 6-year-oldchild presenting with akinetic mutism, using 99mTc-HMPAO single photon emission tomography (SPECT)following high-dose intravenous methotrexate therapy .While findings in X-ray computerized tomography weredecreaseddensity inbilateralbasalgangliaand thalamicnuclei with diffusely decreased attenuation of the periv-entricular white matter, a global, frontal dominant pro-foundly abnormal perfusion pattern involving both grayandwhitematterwasobservedintheSPECTstudy .Treat-mentofthecentralnervoussystemwithhighdoseintra-venouschemotherapymaycauseprofoundabnormalitiesinwhiteandgraymatterbloodflowandearlyassessmentoftheneurotoxicitymaybeidentifiedby99mTc-HMPAOSPECTinthepediatricagegroup .
39 .LeukLymphoma .1997Jul;26(3-4):377-85 . Coexistence of life threatening chemotherapy related
leukoencephalopathy, saggital sinus thrombosis and multiple organ failure in a child with acute lymphoblas-tic leukemia: an unusual case with clinical recovery.
DuruF,ErtemU,DagdemirA,KunakB,KeskinT,SaatciI,GündogduS,CilaA .
Dr. Sami Ulus Children’s Hospital Department of Pediatric Oncology and Neurology, Ankara, Turkey.
Abstract Anine-yearoldgirlwithTcellacutelymphoblasticleuke-
mia (ALL) had acute severe neurologic complications attheendoftheremission-inductionchemotherapycourse .Th irty-sixhours following triple intrathecal (IT) therapyandintravenous(IV)administrationofL-asparaginase(L-asp),tetraplegiadevelopedandshebecameunconscious .Shehadboutsofhypertensionandpersistenttachycardiaunresponsivetodigitalistherapy .Magneticresonanceim-aging(MRI)showedmultiplebrainwhitematterhyperin-tensitiesandfillingdefectsinthesaggitalsinus,suggestingthrombosis .Over the40days, inaddition toherneuro-logic compromise she also had transient diabetes melli-tus, severehyperlipidemia,hypoproteinemiaandedema,liver and heart failure and staphylococcus aureus sepsis
719
Dergi Adı Dergi Kısaltması Impact faktörü Yayın sayısı
1 PediatricHematologyOncology PediatrHematolOncol 0 .891 246
2 TurkishJournalofPediatrics TurkJPediatr 0 .441 222
3 JournalofPediatricHematologyOncology JPediatrHematolOncol 1 .159 118
4 PediatricBloodandCancer PediatrBloodCancer 1 .891 86
5 JournalofPediatricSurgery JPediatrSurg 1 .45 70
6 MedicalandPediatricOncology MedPediatrOncol 1 .891 62
7 Child’sNervousSystem ChildsNervSyst 1 .542 59
8 LeukemiaResearch LeukRes 2 .923 35
9 PediatricNeurosurgery PediatrNeurosurg 0 .703 32
10InternationalJournalofPediatricOtorhinolaryngology
IntJPediatrOtorhinolaryngol 1 .167 30
11 TurkishJournalofHematology TurkJHematol 0 .808 29
12 EuropeanJournalofPediatricSurgery EurJPediatrSurg 0 .808 27
13 PediatricsInternational PediatrInt 0 .626 27
14 Leukemia&Lymphoma LeukLymphoma 1 .674 24
15 PediatricRadiology PediatrRadiol 1 .674 24
16 TurkishNeurosurgery TurkNeurosurg 0 .624 24
17 PediatricTransplantation PediatrTransplant 1 .475 23
18 AmericanJournalofHematology AmJHematol 4 .671 20
19 PediatricSurgeryInternational PediatrSurgInt 1 .253 20
20InternationalJournalofHematologyandOncology
UHOD 0 .349 18
21 CancerGeneticsandCytogenetics CancerGenetCytogenet 1 .389 17
22 JournalofNeuro-Oncology JNeurooncol 3 .214 17
22 Türk Pediatrik Onkoloji Yayınlarının Yer Aldığı Dergiler
BÖLÜM 9 TÜRK PEDİATRİK ONKOLOJİ YAYINLARININ YER ALDIĞI DERGİLER720
23 JournalofNeurosurgery JNeurosurg 2 .965 16
24 ActaHaematologica ActaHaematol 1 .354 14
25 AsianPacificJournalofCancerPrevention AsianPacJCancerPrev 0 .659 14
26 EuropeanJournalofPediatrics EurJPediatr 1 .879 14
27 JournalofChildNeurology JChildNeurol 1 .748 14
28 JournalofPediatrics JPediatr 4 .115 14
29JournalofPediatricEndocrinology&Metabolism
JPediatrEndocrinolMetab 0 .875 14
30 ActaNeurochirurgica ActaNeurochir(Wien) 1 .52 13
31 NeurosurgicalReview NeurosurgRev 2 .036 13
32 PediatricDermatology PediatrDermatol 1 .072 12
33 PediatricNeurology PediatrNeurol 1 .522 12
34 TurkishArchivesofPediatrics TurkArchPed 0 .067 12
35JournalofPediatricOphthalmologyandStrabismus
JPediatrOphthalmolStrabismus 0 .323 11
36 Tumori Tumori 0 .606 11
37 IndianJournalofPediatrics IndianJPediatr 1 .048 10
38 JournalofClinicalNeuroscience JClinNeurosci 1 .247 10
39 TürkiyeKlinikleriTıpBilimleriDergisi JMedSci 0 .102 10
40 SurgeryToday SurgToday 1 .224 10
41 ActaPaediatrica ActaPaediatr 2 .073 9
42 AnnalsofHematology AnnHematol 2 .615 9
43 BoneMarrowTransplantation BoneMarrowTransplant 3 .746 9
44 DiagnosticandInterventionalRadiology DiagnIntervRadiol 1 .1 9
45 EuropeanRadiology EurRadiol 3 .222 9
46JournalofExperimental&ClinicalCancerResearch
JExpClinCancerRes 2 .148 9
47 Radiotherapy&Oncology RadiotherOncol 5 .58 9
48ActaOrthopaedicaetTraumatologicaTurcica
ActaOrthopTraumatolTurc 0 .337 8
49 Cancer Cancer 4 .771 8
50 EuropeanJournalofHaematology EurJHaematol 2 .614 8
51 JournalofCraniofacialSurgery JCraniofacSurg 0 .822 8
52 Leukemia Leukemia 9 .561 8
53ComputerizedMedicalImagingandGraphics
ComputMedImagingGraph 1 .467 7
54 Fetal&PediatricPathology FetalPediatrPathol 0 .613 7
55 JournalofChemotherapy JChemother 1 .084 7
56 JournalofClinicalPediatricDentistry JClinPediatrDent 0 .444 7
721KONU 22 Türk Pediatrik Onkoloji Yayınlarının Yer Aldığı Dergiler
57JournalofPediatricGastroenterologyandNutrition
JPediatrGastroenterolNutr 2 .298 7
58 JournalofTropicalPediatrics JTropPediatr 1 .388 7
59 ActaOncologica ActaOncol 3 .33 6
60 ActaPaediatricaJaponica ActaPaediatrJpn 2 .073 6
61 ActaRadiologica ActaRadiol 1 .369 6
62 AmericanJournalofNeuroradiology AJNRAmJNeuroradiol 2 .928 6
63 AmericanJournalofClinicalOncology AmJClinOncol 2 .005 6
64 IndianPediatrics IndianPediatr 1 .048 6
65InternationalJournalofRadiationOncology*Biology*Physics
IntJRadiatOncolBiolPhys 4 .105 6
66 JournalofAAPOS JAAPOS 1 .028 6
67 JapaneseJournalofInfectiousDiseases JpnJInfectDis 1 .491 6
68 KulakBurunBoğazİhtisasDergisi KulakBurunBogazIhtisDerg NONINDEX 6
69 Mycoses Mycoses 2 .247 6
70 NuclearMedicineCommunications NuclMedCommun 1 .404 6
71 PathologyandOncologyResearch PatholOncolRes 1 .366 6
72 PostgraduateMedicalJournal PostgradMedJ 1 .939 6
73 SaudiMedicalJournal SaudiMedJ 0 .52 6
74 SurgicalNeurology SurgNeurol 1 .669 6
75 ActaChirurgicaBelgica ActaChirBelg 0 .432 5
76 JournalofPediatricHematologyOncology AmJPediatrHematolOncol 1 .159 5
77 AnadoluKardiyolojiDergisi AnadoluKardiyolDerg 0 .439 5
78 BritishJournalofHaematology BrJHaematol 4 .941 5
79 ClinicalNeurologyandNeurosurgery ClinNeurolNeurosurg 1 .581 5
80 ClinicalPediatrics ClinPediatr(Phila) 1 .171 5
81 EuropeanJournalofRadiology EurJRadiol 2 .606 5
82 InternationalJournalofDermatology IntJDermatol 1 .142 5
83 InternationalOphthalmology IntOphthalmol 0 .283 5
84 InternationalUrologyandNephrology IntUrolNephrol 1 .471 5
85 JournalofNeurosurgicalSciences JNeurosurgSci 0 .4 5
86 JournalofNuclearMedicine JNuclMed 6 .381 5
87 JapaneseJournalofClinicalOncology JpnJClinOncol 1 .783 5
88 JapaneseJournalofOphthalmology JpnJOphthalmol 0 .924 5
89 MikrobiyolojiBülteni MikrobiyolBul 0 .402 5
90 MinimallyInvasiveNeurosurgery MinimInvasiveNeurosurg 0 .704 5
91OphthalmicPlastic&ReconstructiveSurgery
OphthalPlastReconstrSurg 0 .691 5
92 Ophthalmology Ophthalmology 5 .454 5
93 PediatricCardiology PediatrCardiol 1 .298 5
BÖLÜM 9 TÜRK PEDİATRİK ONKOLOJİ YAYINLARININ YER ALDIĞI DERGİLER722
94İstanbulÜniversitesiTıpFakültesiMecmuası
TipFakMecm NONINDEX 5
95 TransplantationProceedings TransplantProc 1 .005 5
96 AmericanJournalofRoentgenology AJRAmJRoentgenol 2 .775 4
97 AmericanJournalofDiseasesofChildren AmJDisChild 2 .881 4
98 AnnalsofTropicalPaediatrics AnnTropPaediatr 0 .966 4
99 AustralasianRadiology AustralasRadiol 1 4
100 Blood Blood 9 .898 4
101 BritishJournalofOphthalmology BrJOphthalmol 2 .902 4
102EuropeanArchivesofOto-Rhino-Laryngology
EurArchOtorhinolaryngol 1 .287 4
103 ExperimentalHematology ExpHematol 2 .905 4
104 Helveticapaediatricaacta HelvPaediatrActa NONINDEX 4
105 JournalofClinicalOncology JClinOncol 18 .372 4
106JournalofClinicalResearchinPediatricEndocrinology
JClinResPediatrEndocrinol NONINDEX 4
107 JournalofNeurosurgery:Pediatrics JNeurosurgPediatr 1 .533 4
108 Neuropediatrics Neuropediatrics 0 .937 4
109 Neurosurgery Neurosurgery 2 .785 4
110OralSurgery,OralMedicine,OralPathology,OralRadiologyandEndodontology
OralSurgOralMedOralPatholOralRadiolEndod
1 .457 4
111 Pathology-ResearchandPractice PatholResPract 1 .213 4
112 Th ePediatricInfectiousDiseaseJournal PediatrInfectDisJ 3 .577 4
113 PediatricNephrology PediatrNephrol 2 .518 4
114 PediatricPulmonology PediatrPulmonol 2 .533 4
115 RadiationMedicine RadiatMed 0 .487 4
116 SupportiveCareinCancer SupportCareCancer 2 .597 4
117 EuropeanJournalofPediatricSurgery ZKinderchir 0 .808 4
118 Th eAnnalsofTh oracicSurgery AnnTh oracSurg 3 .741 3
119BiologyofBloodandMarrowTransplantation
BiolBloodMarrowTransplant 3 .873 3
120 Brain&Development BrainDev 2 .119 3
121 CancerInvestigation CancerInvest 1 .847 3
122 Chemotherapy Chemotherapy 1 .816 3
123 ClinicalCancerResearch ClinCancerRes 7 .742 3
124 ClinicalandExperimentalOphthalmology ClinExperimentOphthalmol 1 .977 3
125 Clinicalandlaboratoryhaematology* ClinLabHaematol 1 .971 3
126 ClinicalNuclearMedicine ClinNuclMed 3 .674 3
127 Ear,Nose&Th roatJournal EarNoseTh roatJ 0 .04 3