pathophysiology of tissue growth professor yu.i. bondarenko
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PATHOPHYSIOLOGY OF TISSUE GROWTH Professor Yu.I. Bondarenko. PLAN. 1 . Tumor , it pathophysiological characteristic 2. Е tiology of tumor 3. Conception of oncogene 4. Stages of cancerogenesis. Definition of tumor. - PowerPoint PPT PresentationTRANSCRIPT
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PATHOPHYSIOLOGY OF TISSUE GROWTH
Professor Yu.I. Bondarenko
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PLANPLAN 11..TumorTumor, , it it pathophysiologicalpathophysiological
characteristiccharacteristic 2. Е2. Еtiology oftiology of tumortumor 3. 3. Conception of oncogeneConception of oncogene 4. 4. Stages of Stages of cancerogenesiscancerogenesis
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Definition of tumor Tumor − typical pathological
process in appearance of tissue growth up is characterized with potential unlimited growth, growth
unregulation and atypic cells anaplasia
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Pathophysiologicalcharacteristic of tumor
Anlimited of growthAnregulation of growthAnaplasia of tumor cells
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Methods of tumor cultivation
1. Transplantation 2. Explantation Transplantion stains1. Erlich сarcinoma in mise2. Crocer сarcinoma in mise3. Sаrcoma M-1 in rats4. Carcinoma Braun-Pirs in rabbit Explantation stains1. Cells of HeLa- cervix cancer
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Kinds of cellular аnаplasia
•1. Моrphological•2. Biochemical•3. Physic-chemical•4. Functional•5. Immunological
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Morphological anaplasia
Polymorphism of cells Increase of relation
nucleus /cytoplasma Multinucleonic Hyperchromatosis of
nucleuses Increase of quantity
nucleoles Changes of cell оrganels
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Changes of mitochondriasDecrease of amountDecrease of sizesRefinition of mitochondriale
membranes Decrease of amount crestRefinition of crest
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Biochemical аnaplasiaFeatures of protein metabolism
1. Dysfermentosis2. Unification of isoenzymic spectr3. Activation of nucleonic acids synthesis4. Activation DNA-polymerase5. Increase of protein synthesis 6. Decrease of protein catabolism
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Biochemical аnaplasiaEnergy supply
1. Activation of anaerobic glycolysis2. Present of aerobic glycolysis 3. Activation of glycolic enzymes - pyruvatkinase - hexokinase - fruitkinase4. Inhibition of Krebs cycle
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Physic-Chemical аnaplasia
Acidosis Intracellular hydration Accumulation of potassium Increase of electroconductivity Decrease of colloid viscosity Increase of membranes charge Decrease of surfase tension
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Immunological аnaplasia
Antigen admission Antigen divergence Antigen reversion
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Chemical carcinogens 1. Polycyclic aromatic hydrocarbons 3,4-benzopyrine 1,2,5,6-dibenzoantracene 9,10-dimethyl-1,2- benzoantracene 20- methylcholantren 2. Aromatic аmines and amides monoаzоbenzol 2-аminofluoren 2-naphtylamine chlornaphthisine benzidine
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3. Nitrosamines and nitrosamides N,N-dimethylnitrosamine N-nitrosopyrolidine N-nitrosomethylаniline N-nitrosomorpholine N-methyl- N-nitrosourine
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Formation of carcinogenes
l Precarcinogenel ↓
Proximalcarcinogene
↓Final carcinogene
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VIRAL VIRAL carcinogenesiscarcinogenesis ANIMALSANIMALS:: 1. 1. RaussRauss sarcomasarcoma inin henhen - 1910 - 1910 2. 2. Shope fibroma in rabbitsShope fibroma in rabbits - 1932 - 1932 3. 3. Shope papillomaShope papilloma in rabbitsin rabbits - 1934 - 1934 4. 4. BBііttnerttner milk factormilk factor - 1936 - 1936 PEOPLEPEOPLE:: 1. 1. BurkittBurkittі і lymphomalymphoma– – Central Central ААfricafrica 2. 2. NasopharyngealNasopharyngeal cancercancer – –ChineChine 3. 3. CervixCervix cancercancer
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Activation ofActivation of protooncogeneprotooncogene PointPoint mutationsmutations ChromosomalChromosomal translocationtranslocation ViralViral transductiontransduction Insertion ofInsertion of geneticgenetic materialmaterial Amplification of genesAmplification of genes
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Stages ofStages of carcinogenesiscarcinogenesis
TransformationTransformation − − expression of expression of cell oncogenecell oncogene
PromotionPromotion − − division cellsdivision cells ProgressionProgression− − development ofdevelopment of
tumortumor in a way of malignisationin a way of malignisation
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