Holiday Reminder

The University of Pittsburgh will be closed Thursday, November 27 and Friday

November 28 for the Thanksgiving Recess.

UPMC will be closed Thursday November 27, 2014.

The University of Pittsburgh will be closed December 24 through January 1, 2015.

The Administrative offices will be minimally staffed and open during this time.

University and Hospital offices will reopen January 2, 2015.

Pathology News

N O V E M B E R 2 4 , 2 0 1 4

Let us remember

that, as much has

been given us,

much will be

expected from us,

and that true

homage comes

from the heart as

well as from the

lips, and shows

itself in deeds.

~Theodore

Roosevelt

Greetings to all:

We have started a new academic year facing the chal-

lenges that every academic health care facility across the

country is facing with healthcare issues and government

funding for research. Our new chancellor, Patrick

Gallagher, promises to lead on the Pitt side as he gets to

know Pitt and Pittsburgh. On the training side, we have

welcomed our new house staff and on the staff and faculty

side, everyone is getting used to the new Clinical Labora-

tories Building. We continue to seek international collab-

orations and the Kingmed initiative has brought us even

more opportunities with hospitals in China. The work

done by all in the Department is done with persistence and

determination for a successful outcome. Although the

nation is going through a reorganization of healthcare, and

our new Chancellor must lead in a direction to keep the

University growing and flourishing, we continue to be

competitive and draw the best and brightest students, staff

and faculty.

Please know your accomplishments are noticed and

appreciated. As always, please feel free to see me if you

need anything. My door is always open. Have a safe and

happy holiday season.

Sincerely,

George K. Michalopoulos, M.D., Ph.D.

Special Points of

Interest

Promotions and

Faculty

Highlights

Page 2

Grant

Administration

Page 3

Cellular and

Molecular

Pathology

Page 4-5

Department

Highlights

Page 6-8

Publications

Page 9-13

New Arrivals

Page 11

Presentations

Page 14-15

Medical Education

Program

Page 16-18

Seminars

Page 19

Promotions

P A G E 2

Urvashi Surti, Ph.D. promoted to Professor (with tenure)

Dr. Marie DeFrances has been appointed to the Curriculum Committee of the School of Medicine for a

three year term.

Dr. Sara Monaco completed the College of American Pathologists (CAP) course in Ultrasound-guided

FNA in October 2014.

Alka Palekar, M.D., Received a certificate of Award for outstanding Teaching in

Anatomic Pathology on May 17th 2014 by the chief residents on behalf of University of

Pittsburgh Pathology Residents and Fellows.

Bruce S. Rabin, M.D., Ph.D. was recertified by the American Board of Medical

Laboratory Immunology.

Miguel Reyes-Mugica, M.D. received a $40,000 donation to support "The Gavin Bailey Tissue Repository

for Neural Crest Disorders” from Mr. and Mrs. Travis Bailey and the Nevus Outreach, Inc. Also, newly

elected Director of Education and Technology, International Paediatric Pathology Association (IPPA),

11/2014-

Nidhi Aggarwal, M.D., has joined the Division of Hematopathology as an Assistant Professor effective

September 1, 2014. She completed her residency at the University of Pittsburegh in 2011 and subsequently

did a fellowship in Hematopathology. This was followed by another fellowship in Molecular and Genomic

Pathology.

FACULTY HIGHLIGHTS

WELCOME NEW FACULTY

DEPARTING FACULTY

Two of three retiring faculty were recognized at the Department faculty meeting October 24, 2014.

Rita M. Windisch, Ph.D., FACB, Head of Clinical Chemistry at Mercy Hospital, served from January 1,

1965 to October 1, 2014 and Giuliana A. Trucco, M.D. from Magee Women’s Hospital who was with us

from July 1, 1986 to January 12, 2015. William L. Bigbee, Ph.D. (already relocated to San Diego) was with

the University in several capacities from January 1, 1993 - September 30, 2014 also retired. Their service

was recognized and we wish them the best going forward to the next chapter of their lives.

Grant Administration

P A G E 3

GRANT

SUBMISSIONS

Please note that

assistance for your

grant submissions and

post-award questions

can be found on the

Pathology Website at:

www.path.upmc.edu.

Click Grants

Management for a list

of staff and contact

information as well as

the NIH submission

schedule.

Mary Lou Benedetti,

MHR/IR

Congratulations to Andrew Duncan, Ph.D. he received first RO1 award .

Grant title: Mechanisms of Polyploidy and Aneuploidy in the Liver

Source

NIH / NIDDK

Term

9/25/2014 - 6/30/2019

Amount

$1,440,450 (direct)

$2,174,309 (total)

Yuri Nikiforov, M.D., Ph.D.—NIH RO1

Grant title: Translational Evaluaton of Aging, Inflammation and HIV in Lung

Dysfunction

Source: NIH

Term: 7/1/2014 - 5/31/2019

Amount: $1,568,605

Alejandro Soto-Guterierrez, M.D., Ph.D.

Grant title: Mini-livers Derived from Human iPS Cells for Modeling Steatosis

and Therapy

Term: 8/1/2014 - 7/31/2018

Amount: $1,239,952

Sarah Wheeler, DOD

Grant Title: Regulation of Metastatic Breast Cancer Dormancy

Term: 9/30/2014 - 9/29/2017

Amount: $460,029

Jennifer Picarsic, M.D. , collaborating with….

Dr. Heth Turnquist, Assistant Professor of Surgery and Immunology, as a Patholo-

gy Consultant on a Roche Organ Transplantation Research Foundation Grant, enti-

tled, “Prognostic value and function of IL-33/ST2 in pediatric heart transplant re-

cipients with infection.

Michael Shurin, M.D., Ph.D.

Ovarian Cancer Research Fund (OCRF), Program Project Development Grant

(2014-2016) Proposal #: 327038 “Microenvironmental control of premalignant

lesions in ovarian cancer” (Shurin – Project 1 Leader)

Thanksgiving Day

comes, by statute, once

a year; to the honest

man it comes as

frequently as the heart

of gratitude will allow.

~Edward Sandford

Martin

essayist and poet

1856-1939

P A G E 4

Dear Colleagues:

I am happy to report that our program continues to do quite well although due to high graduation rates we

are starting to shrink a little. During the course of the past academic school year, nine students graduated; how-

ever, we also added 5 new students (4 from IBGP and 1 from MSTP), putting us at 27 students so that we contin-

ue to remain one of the largest of the six Interdisciplinary Program affiliates. Despite losing some faculty mem-

bers through career changes, overall our faculty numbers have been growing. This past academic year we added

3 new faculty members to CMP: Melanie Scott and Janet Lee (primary), as well as Sharyl Fyffe-Maricich and

Angus Thomson, secondary) making our current total 68. Please remember to tell interested faculty about join-

ing CMP. We are always interested in adding qualified SOM faculty to our graduate program if their interests

match with ours.

On May 28, we held our highly successful Pathology Retreat, successfully combining our basic and clini-

cal researchers for an afternoon of stimulating talks, followed by a poster session at the University Club. For

those of you who missed it, our keynote speaker was Jon Morrow, MD/Phd, the Chairman of Pathology at Yale.

In house faculty invited to present their research were Peter Lucas, Marie DeFrances, and Sanja Dacic. As most

of you know, I could not have done the retreat without the help of Tara Rohall our administrative assistant, Tara

Rohall (rohallta@upmc.edu) who basically took on this daunting task as one of her first after coming on board

last spring. I think all who were there would agree she did a stand up job!

As in the past, posters were judged and the following were winners in the various categories:

Graduate students:

First place: Lindsey Kelly (mentor: Yuri Nikiforov)

Second place: Edgar Tafaleng (mentor: Ira Fox)

Third place: tie between Beth Oczypok and Katie Wack (mentors: Tim Oury and Donna Stolz, respectively;

each will receive the full prize money)

Basic Research:

First place: Xinwei Wang (mentor: Jian Yu)

Second place: Kan He (mentor: Jian Yu)

Third place: tie between Chante Richardson and Amanda Clark (mentors: Grant Bullock and Alan Wells, re-

spectively; each will receive the full prize money)

Clinical Research:

First place: Jason Chiang (mentor: Clayton Wiley)

Second place: Tanner Bartholow (poster 68 on Hereditary Pancreatitis; mentor: Aatur Singhi)

Third place: Zaibo Li (poster 72 on HER2, mentor: Rohit Bhargava)

From the desk of Dr. Wendy M. Mars ….

CELLULAR AND MOLECULAR PATHOLOGY

P A G E 5

Finally-hold these dates…our annual retreat will be May 22, 2015 with Dr. Kojo Elenitoba-

Johnson from the University of Michigan as our on campus keynote speaker, along with several student

and faculty speakers, and an evening poster session at the University Club. More information will follow

in the next newsletter. The Summer Undergraduate Research Program (SURP) will begin on May

26, 2015. For SURP, we are once again actively seeking interested faculty willing to host college under-

graduates in their laboratories for a 10-week scientific research experience. SURP is a highly competitive

outreach program, specifically designed to recruit high quality students into applying for graduate degrees

through the University of Pittsburgh School of Medicine (UPSOM) programs such as the Interdisciplinary

Biomedical Graduate Program and the Medical School.

The specifics of SURP are as follows:

The cost to the individual investigator is $3500.00. In some cases, there may be supplemental

funding from UPSOM. Please contact me at 412-648-9690 or wmars@pitt.edu if you are

interested in learning more about these funding opportunities.

The program will run from May 26-July 31. Students are expected to have a specific project

that they work on full time. They are also expected to attend supplemental programming 1-

2 hours a week. At the end of the experience they must write an abstract and do a 10-

minute power point presentation of their work.

Student housing and travel will generously be provided by UPSOM.

The success of this program relies on quality mentors well as quality students. Part of our

past success has been due to participation of interested faculty such as you. In addition, we have

implemented several techniques designed to attract the highest quality students to our program

such as a shared online application process. I would venture that many of you who have participat-

ed as SURP mentors in the past can attest to the quality of the students that we are attracting. You

need not be graduate faculty to take on a student.

If you have any questions or are willing to be a mentor this year, please contact me at 412-648-

9690, or via e-mail at wmars@pitt.edu. The application process has already begun. Also, remember that

if you are interested in having issues brought before the CMP steering committee, please share them with

either our CMP administrator, Tara Rohall (rohallta@upmc.edu), or with me (wmars@pitt.edu).

Thanks so much!

Wendy M. Mars, Ph.D.

Director, Pathology SURP and CMP Graduate Program

FOR ALL MEDICAL DOCTORS

ACT 31 OF 2014: INITIAL TRAINING AND

CONTINUING EDUCATION IN CHILD ABUSE

RECOGNITION AND REPORTING REQUIREMENTS

The Bureau of Professional and Occupational Affairs (BPOA), in conjunction with the Department

of Public Welfare (DPW), is providing advance notice to all health-related licensees and funeral di-

rectors that are considered "mandatory reporters" under section 6311 of the Child Protective Services

Law (CPSL) (23P.S. $6311), as amended, that effective January 1, 2015 all persons applying for is-

suance of an initial license shall be required to complete three hours of DPW approved training in

child abuse recognition and reporting requirements as a condition of licensure. Additionally, effec-

tive with the first license renewal after January 1, 2015 all health-related licensees and funeral direc-

tors applying for the renewal of a license issued by the Board shall be required to complete at least

two hours of Board-approved continuing education in child abuse recognition and reporting require-

ments as a condition of renewal.

Please note that Act 31 applies to all health-related licensees, regardless of whether they are subject

to the continuing education requirements of the applicable board. More information regarding this

requirement will be posted on the BPOA website when it is available. For questions, contact Judy

Nestico at nesticojc@upmc.edu. Thank you.

P A G E 6

7 SCAIFE RENOVATION UPDATE

Have you noticed the construction workers moving about and heard the pounding and drilling on the

7th floor of Scaife for the last four to five months? Aim Construction was hired for the Scaife SE

Wing full-scale renovation project. After many months of planning, work on the designs for the state

-of-the-art open lab with glass walls separating the space is currently in progress. The existing labs

and staff were relocated to temporary space on the seventh and eighth floors of Scaife, and the entire

SE Wing was demolished in July. Construction is nearing completion and all the Neuropathology

labs and some Lab Medicine research labs will move in January 2015.

All of the Neuropathology Division will be located on 7 Scaife after the SE Wing is complete. Cur-

rently, the reception and Division Director's Office is now in S701 Scaife, and their sign-out room,

fellows' office and faculty offices occupy the east side of the A-Stem.

When Molecular Diagnostics moved to the CLB, the Scaife SW Wing was renovated, and now it is

occupied by Dr. Jianhua Luo's labs, Dr. Charleen Chu's labs, and Dr. Tim Oury's labs and office. The

NW Scaife wing now houses Dr. Luo's office and the Biospherex Equipment Room.

When the newly renovated labs and offices are pristine and complete, faculty and staff new to the 7th

floor of Scaife will join those who have been there.

Judy Nestico

Pathology Conference in China

In September 2014 the Department of Pathology at UPMC partnered with 301 Hospital in China to

have the first combined pathology conference between these two organizations in Beijing. For an over-

view of the meeting in Chinese you can visit: http://www.301hospital.com.cn/web/shownews/

yyxw/2347.html 301 Hospital is a large, modern hospital with state-of-the art facilities. It is the largest

general hospital of the Chinese People’s Liberation Army. This 4000 bed hospital has over 3.8 million

patient outpatient visits, 140,000 admissions and undertakes over 68,000 operations. The Depart-

ment of Pathology in Hospital 301, much like the AFIP, is renowned nationwide.

Three pathologists from UPMC (Drs Chengquan Zhao, Liron Pantanowitz and Anil Parwani) attended this

meeting. Dr Zhao was one of the key organizers of the meeting. He lectured on common breast lesions,

the role of immunohistochemistry in gynecological pathology, and presented several unknown challeng-

ing cases. Dr Pantanowitz gave lectures on approaches to spindled and myxoid soft tissue tumors. Dr

Parwani spoke about prostate pathology and gave an informative update on the new classification of

renal tumors. Eight expert pathologists from 301 Hospital also presented lectures in various subspeci-

alities. These talks were well received by an attentive audience comprised of around 150 practicing

pathologists and trainees. The meeting was a huge success and everyone is eager for the next com-

bined pathology conference.

This important pathology meeting signifies the establishment of a new collaborative academic relation-

ship between our pathology department at UPMC and that of 301Hospital, one of the largest general

hospitals in China. The intent is to foster collaboration in areas of clinical practice, research, education

and training. Both parties can benefit from the large diversity of patients they serve, pathologies en-

countered, and the talent of their pathologists. This partnership enhances the international visibility

and reputation of both organizations.

P A G E 7

DIVISION OF ANATOMIC PATHOLOGY

First Row: Dr. Simon Chiosea, Dr. Paul Ohori, Dr. Julia Kofler, Dr. Robert Peel, Dr. Reet Pai, Dr. Karen Schoedel

Second Row: Dr. Raj Seethela, Dr. Jeffrey Nine, Dr. Shih Fan Kuan, Dr. Jon Davidson, Dr. Aatur Singhi,

Dr. Sanja Dacic, Dr. Sheldon Bastacky, Dr. Changqing Ma

Third Row: Dr. Michael Landau, Dr. Douglas Hartman, Dr. Samuel Yousem, Dr. Frank Schneider,

Dr. Michel Nalesnik

Faculty Awards

Robert Austin, M.D., received the 2014 ASC’s Panpanicolaou Award. This is the Ameri-

can Society of Cytopathology’s highest honor and is given in recognition of meritorious

contributions in the field of cytopathology.

Dr. Rajiv Dhir is the winner of the Award for Commitment and

Excellence in Services (ACES) and recipients of this award are

recognized at an ACES recognition dinner at the David Lawrence

Convention Center.

Annette Duensing, M.D. received the Jeroen Pit Science Award,

The Life Raft Group (11/2014) and the GIST Science Award, GIST

Patient Group Switzerland (11/2014)

Darrell Triulzi, M.D. was a recipient of this year's AABB President

Award recognizing more than a decade of research on the NIH

REDS research network leading to improvements in blood

availability and safety. (picture to right)

P A G E 8

Qu, H., Tu, Y., Guan, J-L., Xiao, G., and Wu*, C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve

as a regulatable switch in the integrin outside-in signaling circuit. J. Biol. Chem. (2014) First Published on September

18, 2014, doi:10.1074/jbc.M114.580811.

Huang H, Tosun AB, Guo J, Chen C, Wang W, Ozolek JA, Rohde GK. Cancer diagnosis by nuclear morphometry

using spatial information. Pattern Recognit Lett. 2014 Jun 1;42:115-121.

Bhagavatula R, McCann MT, Fickus M, Castro CA, Ozolek JA, Kovacevic J. A vocabulary for the identification

and delineation of teratoma tissue components in hematoxylin and eosin-stained samples. J Pathol Inform. 2014 Jun

30;5:19. doi: 10.4103/2153-3539.135606. eCollection 2014.

Gustavo Rohde, John Ozolek, Anil Parwani, Liron Pantanowitz. CMU bioimaging day 2014: Challenges and op-

portunities in digital pathology. J Pathol Inform 2014;5:32.

Eisses JF, Davis AW, Tosun AB, Dionise ZR, Chen C, Ozolek JA, Rohde GK, Husain SZ. A computer-based auto-

mated algorithm for assessing acinar cell loss after experimental pancreatitis. PLoS One. 2014 Oct 24;9

(10):e110220. doi: 10.1371/journal.pone.0110220. eCollection 2014.

Boichuk S, Lee DJ, Mehalek KR, Makielski KR, Wozniak A, Seneviratne DS, Korzeniewski N, Cuevas R, Parry JA,

Zewe JP, Brown MF, Taguchi T, Schöffski P, Debiec-Rychter M, Duensing A. Unbiased compound screening identi-

fies unexpected drug activities and novel treatment options for gastrointestinal stromal tumors (GIST). Cancer

Res. 2014; 74:1200-1213.

DeCaprio JA, Duensing A. The DREAM complex in anti-tumor activity of imatinib in gastrointestinal stromal tu-

mors. Curr Opin Oncol 2014; 26:415-421.

Boichuk S, Rausch JL, Duensing A. New developments in the management of gastrointestinal stromal tumours:

Regorafenib, the new player in the team. Gastrointestinal Cancer: Targets and Therapy 2014; 4:1-10.

DeWard A., Komori J. and Lagasse E. Ectopic transplantation sites for cell-based therapy. Current Opinion in Or-

gan Transplantation. (2014). Apr;19(2):169-74. PMID: 24480968

Cramer J.M., Zimmerman M.W., Thompson T., Homanics G.E., Lazo J.S., Lagasse E. Deletion of Ptp4a3 reduces

clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice. (2014) Stem Cell Research. Epub

(2014) May 27. PMID: 24950307

DeWard D. A., Cramer J.M., and Lagasse E. Cellular heterogeneity in the mouse esoph-

agus implicates the presence of a non-quiescent epithelial stem cell population. Cell Re-

ports. Published online: October 16th , 2014. http://www.cell.com/cell-reports/pdf/S2211

-1247(14)00810-9.pdf

Georgievskaya Z, Nowalk AJ, Randhawa P, Picarsic J. Bartonella henselae endocarditis

and glomerulonephritis with dominant C3 deposition in a 21-year-old male with a Melo-

dy transcatheter pulmonary valve: case report and review of the literature. Pediatr De-

velopmental Pathology. 2014 Jul-Aug;17(4):312-20

PUBLICATIONS

P A G E 9

Kaynar AM, Yende S, Zhu L, Frederick DR, Chambers R, Burton CL, Carter M, Stolz DB, Agostini B,

Gregory AD, Nagarajan S, Shapiro SD, Angus DC. Effects of intra-abdominal sepsis on atherosclerosis

in mice. Crit Care. 2014 Sep 3;18(5):469. doi: 10.1186/s13054-014-0469-1. PubMed PMID: 25182529;

PubMed Central PMCID: PMC4172909.

2: Zhu X, Ng HP, Lai YC, Craigo JK, Nagilla PS, Raghani P, Nagarajan S. Scavenger receptor function

of mouse Fcγ receptor III contributes to progression of atherosclerosis in apolipoprotein E hyperlipidem-

ic mice. J Immunol. 2014 Sep1;193(5):2483-95. doi: 10.4049/jimmunol.1303075. Epub 2014 Jul 18.

PubMed PMID: 25038257; PubMed Central PMCID: PMC4135013.

Singhi AD, Nikiforova MN, Fasanella KE, McGrath KM, Pai RK, Ohori NP, Bartholow TL, Brand RE,

Chennat JS, Lu X, Papachristou GI, Slivka A, Zeh HJ, Zureikat AH, Lee KK, Tsung A, Mantha GS,

Khalid A. Preoperative GNAS and KRAS testing in the diagnosis of pancreatic mucinous cysts. Clin

Cancer Res. 2014 Aug 15;20(16):4381-9.

Singhi AD, Lilo M, Hruban RH, Cressman KL, Fuhrer K, Seethala RR. Overexpression of Lymphoid

Enhancer-Binding Factor 1 (LEF1) in solid-pseudopapillary neoplasms of the pancreas. Mod Pathol.

2014 Oct;27(10):1355-63.

Singhi AD, Pai RK, Kant JA, Bartholow TL, Zeh HJ, Lee KK, Wijkstrom M, Yadav D, Bottino R, Brand

RE, Chennat JS, Lowe ME, Papachristou GI, Slivka A, Whitcomb DC, Humar A. The histopathology of

PRSS1 hereditary pancreatitis. Am J Surg Pathol. 2014 Mar;38(3):346-53.

P A G E 1 0

PUBLICATIONS

Shurin M.R., Keskinov A.A. Low-Dose Chemomodulation and Cancer Vaccines. Editorial. J Vaccines

Vaccination, 5: e126. doi: 10.4172/2157-7560.1000e126, 2014.

Zhong H, Gutkin D.W., Han B., Ma Y., Keskinov A.A., Shurin M.R., Shurin G.V. Origin and pharmaco-

logical modulation of tumor-associated regulatory dendritic cells. Intl J Cancer, 134(11):2633-45, 2014.

Shurin M.R., Yanamala N., Kisin, E.R., Tkach A.V., Shurin G.V., Murray A., Leonard H., Reynolds J.,

Gutkin D.W., Star A., Fadeel B., Savolainen K., Kagan V.E., Shvedova A.A. Graphene Oxide Attenuates

Th2-type Immune Responses, but Augments Airway Remodeling and Hyperresponsiveness in a Murine

Model of Asthma. ACS Nano, 2014, in press.

Anani W.Q., Ojerholm E.J., Shurin M.R. Resolving Transferrin Isoforms by Aga-

rose Gel Electrophoresis. Lab Medicine, in press, 2014.

Kisin E., Yanamala N., Farcas M., Gutkin D., Shurin M., Kagan V., Bugarski A.,

Shvedova A. Abnormalities in Male Reproductive System after Exposure to Die-

sel and Biodiesel Blend. Environmental and Molecular Mutagenesis, in press,

2014.

Agassandian M., Shurin G.V., Ma Y., Shurin M.R. C-reactive protein and lung diseases. The Intl J Bio-

chem Cell Biology, 53: 77-88, 2014.

RK Dagda, I Pien, R Wang, J Zhu, KZQ Wang, J Callio, TD Banerjee, RY Dagda & CT Chu (2014) Be-yond the mitochondrion: cytosolic PINK1 remodels dendrites through Protein Kinase A. J Neurochem 128: 864-877. doi: 10.1111/jnc.12494. PMCID: PMC3951661

Commentary: http://dx.doi.org/10.1111/jnc.12529. J Neurochem 128: 787-789.

E Plowey, JW Johnson, D Eisenberg, NM Valentino, YJ Liu & CT Chu. Mutant LRRK2 overexpression in cultured cortical neurons elicits glutamatergic synapse activity and excitotoxic neurite degeneration. Bi-ochim. Biophys. Acta (Molecular Basis of Disease) 1842: 1596-1603. http://www.sciencedirect.com/science/article/pii/S0925443914001446 PMCID: PMC4144018

LH Sanders, J McCoy, X Hu, PG Mastroberardino, BC Dickinson, CJ Chang, CT Chu, B Van Houten, JT Greenamyre. (2014) Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson’s disease. Neurobiol Dis 70: 214-223. PMCID: PMC4144978

NK Mesiwala, CT Chu, LV Raju. (2014) Infectious crystalline keratopathy predominantly affecting the pos-terior cornea. Int J Clin Pathol 7: 5250-5253. PMCID: PMC4152095

Book Chapters and Reviews

CT Chu. (2014) Autophagy. In Encyclopedia of Neurological Sciences, 2nd edition. (Michael J. Aminoff and Robert B. Daroff, Editors). Oxford: Academic Press. Volume 1, pp. 355-357.

Monaco, S.E., W.E. Khalbuss, L. Pantanowitz, Editors, Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration, Karger Publishers.

PUBLICATIONS

Matthew Then, M.D. (UPMC East) and his wife Janine welcomed

their first child Nathan Robert on April 26. Nathan weighed 9 lbs

and 2 ozs.

David Azar, M.D. (Mercy Hospital) and wife Donna welcomed

twin boys James Sawyer and Desmond Thomas Azar

November 3, 2014 and weighing 5lb 14oz and 5lb 12oz. Respectively. All are

doing well.

Nidhi Aggarwal, M.D. and her husband Rohit welcomed their first

child, Kavya, September 6, 2014 weighing 7 pounds and 12 ounces.

New Arrivals - CONGRATULATIONS

P A G E 1 1

Salgado C M, Silver RB, Bauer BS, Basu D, Schmitt L, Khakoo Y, Reyes-Múgica M. Skin Of Patients

With Large/Giant Congenital Melanocytic Nevi Shows Increased Mast Cells. Pediatr Dev Pathol. 2014 May

-Jun;17(3):198-203. doi: 10.2350/14-02 1444-OA.1.

Basu D, Lettan R, Krishnan D, Strellec S, Reyes-Múgica M, Rebbaa A. Identification, Mechanism Of Ac-

tion And Anti-Tumor Activity Of A Small Molecule Inhibitor Of Hippo, Tgf Beta, And Wnt Signaling

Pathways. Mol Cancer Ther Jun;13(6):1457-67. doi: 10.1158/1535-7163.MCT-13-0918. Epub 2014 Apr 2.

Trejo Bittar HE, Radder JE, Ranganathan S, Reyes-Múgica M. Clear Cell Sarcoma of the Kidney In A

Child With Fanconi Anemia. Pediatr Dev Pathol. 2014 Apr 15. [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 1. Normal Development of Testicular

Structures: From The Bipotential Gonad To The Fetal Testis. Pediatr Dev Pathol. 2014 Aug 13. [Epub

ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 2. Testicular Descent. Pediatr Dev Pathol.

2014 Jul 30. [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 3. Testicular Development from birth to

puberty. Systematic evaluation of the prepubertal testis. Pediatr Dev Pathol. 2014 Jul 30. [Epub ahead of

print].

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 4. Pubertal and Adult Testis. Pediatr Dev

Pathol. 2014 Jul 30. [Epub ahead of print].

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 5. Gonadal dysgenesis. Pediatr Dev

Pathol. 2014 August 8 [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. Male undermasculinization. Pediatr Dev

Pathol. 2014 August 8 [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 7. Ovotesticular DSD (True hermaphro-

ditism). Pediatr Dev Pathol. 2014 August 8 [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 8. Persistance of embryonal remnants in

the testis. Pediatr Dev Pathol. 2014 August 8 [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 9. Alterations in the number and location

of the testis. Pediatr Dev Pathol. 2014 August 8 [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 10. Ectopic and heterotopic tissues in the

testis. Pediatr Dev Pathol. 2014 August 8 [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 11. Testicular Pathology of Hamartoma-

tous origin. Pediatr Dev Pathol. 2014 August 8 [Epub ahead of print]

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Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 12. Congenital epididymal anoma-

lies. Pediatr Dev Pathol. 2014 Aug 13. [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 13. Calcifications in the testis and par-

atesticular structures. Pediatr Dev Pathol. 2014 August 8 [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 14. Natural history of undescended tes-

tes. Pediatr Dev Pathol. 2014 August 8 [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 15. Macroorchidism As The Expression

Of Several Congenital And Acquired Pathologies. Pediatr Dev Pathol. 2014 August 8 [Epub ahead of

print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 16. Klinefelter syndrome and other

anomalies in X and Y chromosomes. Clinical and pathological entities. Pediatr Dev Pathol. 2014

August 8 [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. Testicular Torsion, testicular appendix

torsion and other forms of testicular infarction. Pediatr Dev Pathol. 2014 August 8 [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 20. Adolescent varicocele. Pediatr

Dev Pathol. 2014 August 8 [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 21. Testicular pathology in inherited met-

abolic diseases. Pediatr Dev Pathol. 2014 Oct 31. [Epub ahead of print]

Nistal M, Paniagua R, González-Peramato P, Reyes-Múgica M. 22. Testicular involvement in

systemic diseases. Pediatr Dev Pathol. 2014 Oct 21. [Epub ahead of print].

Tian AG, Foster KA, Jakacki R, Reyes-Múgica M, Greene S. Neurocutaneous melanosis is

associated with tethered spinal cord. Childs Nerv Syst. 2014 Aug 15. [Epub ahead of print].

Lezcano C, Simons JP, Colman KL, Cohen MS, Lin PL, Reyes-Múgica M. Actinomycosis

Mastoiditis Complicated by Sigmoid Sinus Thrombosis and Labyrinthine Fistula. Pediatr Dev

Pathol. 2014 Aug 18. [Epub ahead of print]

Andrews R, Baumhardt H, Martin B, Belachew D, Reyes-Múgica M. Oral Manifestations of

Hyperpara thyroidism Secondary to Familial Hypophosphatemic Rickets. Pediatr Dentistry 2014;

36 (5):422-424.

Picarsic J, Reyes-Múgica M. Phenotype And Immunophenotype Of The Most Common Pediatric

Tumors. Appl Immunohistochem Mol Morphol Appl Immunohistochem Mol Morphol. 2014 Nov 11.

Epub ahead of print]

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Annett Duensing, M.D.

Targetable pathways in GIST”, GI Pathway Sessions; "e-Grandround“; European School of Oncology

(ESO) in collaboration with Nature Reviews in Clinical Oncology/Critical Reviews in Oncology Hematolo-

gy (July 2014).

Boichuk S, Makielski KR, Brown MF, Rausch JL, Weil EW, Ali AA, Duensing A. The role of ABL1 in

the therapeutic response of GIST cells to imatinib mesylate. Connective Tissue Oncology Society (CTOS),

18th Annual Meeting, October 30-November 2, 2013, New York, NY.

Rausch JL, Ali AA, Mehalek KR, Agha A, Wolf M, Weil EW, Dhillon H, Francis J, Makielski KR,

Taguchi T, Duensing A. Second-generation inhibitors of the proteasome as novel treatment options for gas-

trointestinal stromal tumors (GISTs). Connective Tissue Oncology Society (CTOS), 19th Annual Meeting,

October 15-18, 2014, Berlin, Germany.

George K. Michalopoulos, M.D., Ph.D., gave the 6th Annual Marvin Kuschner Memorial Lecture at

Stony Brook University, Stony Brook NY on November 20, 2014. Title of presentation was “Liver

Regeneration.”

Jennifer Picarsic, M.D.

Presented at the 30th annual Histiocyte Society Annual Meeting in Toronto, ON: Langerhans cell hyperplas-

ia, Langerhans cell histiocytosis (LCH), and the thymus: a clinicopathologic study and review of the

Literature

Aatur Singhi, M.D.

“Integration of DNA Testing in the Preoperative Diagnosis of Pancreatic Cystic Neoplasms”, GI Cancer

Symposium: Current Trends in Pancreatic and Hepatobiliary Malignancies, April 26, 2014, Pittsburgh, PA.

“Histologic Differences of Pancreatitis Pathology with Different Etiologies”, PancreasFest 2014, July 24,

2014, Pittsburgh, PA.

“Things that Confuse and Frustrate GI Pathologists: Pancreatobiliary Frozen Sec-

tions”, American Society for Clinical Pathology (ASCP) 2014 Annual Meeting,

October 10, 2014, Tampa Bay, FL.

Michael Shurin, M.D., Ph.D.

“Nanomaterials and Cancer: Friends or Foes?”, Ben Gurion University of the

Negev, Beer Sheva, Israel. 2014.

PRESENTATIONS

P A G E 1 4

Charleen T. Chu, MD, PhD

Mitophagy & Parkinson’s Disease: Hanging in the Balance. Keystone Symposia Conference on Autophagy:

Fundamentals to Disease, May 24, 2014, Austin, TX.

Regulation of neuronal mitophagy: Cardiolipin externalization as a signaling mechanism. United Mitochon-

drial Disease Foundation: Mitochondrial Medicine, 2014. June 7, 2014, Pittsburgh, PA.

Mitochondrial Quality Control in Parkinson's Disease: A Primary Neuron Perspective. University of Minne-

sota, Twin Cities, Neuroscience Departmental Seminar Series, Sept. 12, 2014, Minneapolis, MN.

Mitochondrial Quality Control and Parkinson's Disease Genes. Basic and Translational Research in Lung

Disease Conference. University of Pittsburgh, Sept 16, 2014.

Mechanisms of mitophagy and mitochondrial biogenesis, in Averting an Energy Crisis: The Vital Role of

Mitochondria in PD. WPC Scientific Update: Parkinson’s Pipeline Umbrella, Sept 30, 2014, webcast.

PRESENTATIONS

P A G E 1 5

Will Smith’s Concussion Movie and UPMC Pathology

Sony Pictures is currently filming a movie in Pittsburgh that will star Will Smith as Dr. Bennet Omalu

(a former Neuropathology Fellow) and Stephen Moyer as Dr. Ronald Hamilton. The movie will be

about the discovery of Chronic Traumatic Encephalopathy in NFL football players and the reaction of

the NFL to this discovery (they were not happy). It is being produced by Ridley Scott and directed by

Peter Landesman (“Parkland”). The movie will also star Alec Baldwin and Albert Brooks. Jonette

Werley, who has been with Neuropathology for over two decades, originally cut and stained the slides

on the first case. She was filmed processing tissues and preparing slides as part of planned montage

sequence. We look forward to seeing her on the big screen!

Ronald Hamilton, M.D.

Miguel Reyes-Mugica, M.D.

International Pediatric Pathology Association (IPPA). Berlin, Germany. September 12-21,

2014. 2014 Recommended approach for the evaluation of the pediatric testis, from the neonate to the begin-

ning of adulthood. This lecture will offer a review of the normal histology and pertinent processes testicular

development, with correlations to significant deviations from the normal patterns. Practical approaches to

objective evaluation of testicular components will be included.

Disorders of sex development (DSD). This lecture will cover the main forms of DSD with correlations

to clinical phenotype, appropriate histological and immunophenotypical analysis.

Pediatric testicular tumors in the setting of DSD. This lecture will review the main testicular tumors

arising as part of a DSD, their morphology and immunohistochemical analysis.

Pediatric melanocytic proliferations. This lecture will review current understanding of congenital mela-

nocytic disorders, including giant/large congenital melanocytic nevi and associated lesions: neurocutaneous

melanocytosis, proliferative nodules, melanoma. Other forms of pediatric nevi, including Spitz lesions will

be reviewed.

Six case presentations.

Residents

Recruitment for July 1, 2015 Class has commenced. There will be 12 interview days with 6 candidates

each day. Select MD PhD candidates are being considered for the research track.

The American Board of Pathology recently endorsed a research track that is similar to our long stand-

ing PIRRT program.

Senior residents will be taking a Laboratory Management Certification program offered by the ASCP.

Dr. Pantanowitz is part of a national initiative to create a PIER (Pathology Informatics Education for

Residents) curriculum that is being tested over the next 2 years. UPMC is one of 13

alpha testing sites of the 40 hour curriculum.

The first ACGME required reporting of milestones for each resident is due by January 9, 2015

Fellows

We have 17 fellows and 5 Clinical Instructors this year.

Recruitment for fellows starting July 1, 2016 is open and slots are being filled

As of July 1, 2016 the maximum number of fellows in any fellowship will be 2 fellows.

The new ACGME required milestones for fellowships will commence July 2015.

Humberto Trejo Bittar, MD, Resident, Anatomic Pathology, PGY-3

Trejo Bittar HE, Yousem S, Wenzel S. Pathobiology of severe asthma. Annual Review of

Pathology. 2015 February (10). Accepted for publication.

Trejo Bittar HE, Dacic S, Pantanowitz L. Detection of Merkel Cell Polyomavirus In Lung Adenocar-

cinomas Carcinomas. Role of Immunohistochemistry. CAP meeting 2014, Chicago.

Trejo Bittar HE, Radder J, Reyes-Mugica M. Clear Cell Sarcoma of the Kidney in a Child with Fan-

coni Anemia. CAP meeting 2014, Chicago.

Trejo Bittar HE, Nikiforova M, Yousem S. c-kit (CD117) Is Overexpressed in a Subset of Lung Ade-

nocarcinomas. A Morphologic and Genetic Analysis. CAP meeting 2014, Chicago.

Positions:

Selected Junior Member of the CAP Histotechnology Committee for 2015.

From the desk of Dr. Trevor Macpherson…..

MEDICAL EDUCATION PROGRAMS

P A G E 1 6

PITT’S HOLIDAY GIFT DRIVE NOVEMBER 17—DECEMBER 15, 2014

Drop off gifts for the annual holiday collection at 710 Alumni Hall. Should have a retail value of $20-25 and be marked for

boy/girl and age of child. The gifts are given to the Salvation Army for distribution to the needy.

SOCKS, HATS , SCARVES AND GLOVES collection NOVEMBER 24-DECEMBER 12, 2014. Drop off bin on 4th floor of Scaife

Hall. Also given to Salvation Army Your thoughtfulness and generosity is appreciated.

Residency Program:

New PGY-1 Class – July 2014:

Lama Farchoukh, MD – American University of Beirut

Michelle Heayn, MD, PhD – Temple University School of Medicine

Thomas Pearce, MD, PhD – Washington University in St. Louis School of Medicine

Dinesh Pradhan, MD – Gauhati Medical College

Jansen Seheult, MD – Royal College of Surgeons in Ireland School of Medicine

Michelle Stram, MD – State University of New York Upstate

Christopher Suciu, MD – Tulane University School of Medicine

Jennifer Yoest, MD – University of Pittsburgh

Fellowship Program:

Fellows – July 2014

Seven fellows have been recruited from outside programs together with ten internal candidates. A total of seventeen

trainees will begin their fellowships on July 1, 2014.

Jason Chiang, MD, PhD (NP) – UPMC – AP residency

Casey Gooden, MD (Heme) – Emory University – AP/CP residency

Christopher Griffith, MD, PhD (Cyto) – UPMC – AP residency

Sarika Jain, MD (MGP) – UPMC – AP/CP residency

Arivarasan Karunamurthy, MD (MGP) – UPMC – AP/CP residency

Rebecca Leeman-Neill, MD, PhD (Heme) – UPMC – AP residency

Kate McFadden, MD (Peds) – UPMC – AP/NP residency

Erika Moore, MD (Heme) – Hospitals of the University of Pennsylvania – AP/CP residency

Lananh Nguyen, MD (Cyto) – UPMC – AP residency

Rebecca Ocque, MD (Cyto) – UPMC – AP/CP residency

Gabriela Quiroga-Garza, MD (GU) – The Methodist Hospital – AP/CP residency

Lisa Radkay-Gonzalez, MD (SP) – UPMC – AP/CP residency

Gregory Riedlinger, MD, PhD (MGP) – Laboratory of Pathology, NCI, NIH – AP residency

Alison Van Dyke, MD, PhD (Thoracic) – Yale-New Haven Hospital – AP residency

Sarah Voss, MD (Transplant) – Penn State Milton S. Hershey Medical Center – AP/CP residency

Lindsay Williams, MD (H&N) – William Beaumont Health System – AP/CP residency

Oleksandr Yergiyev, MD (BST) – Allegheny General Hospital – AP/CP residency

Clinical Instructors – July 2014

Five clinical instructors have also been recruited.

Justin Fender, MD (GI) – Mount Sinai Medical Center – AP/CP residency

Grzegorz Gurda, MD (GYN/Breast) – The Johns Hopkins Hospital – AP/CP residency

Jennifer Leidy, MD (GYN/Breast) – University of Massachusetts – AP/CP residency

Jenny Mas Moya, MD (GI) – Emory University School of Medicine – AP/CP residency

David Webb, MD (GYN/Breast) – University of Virginia – AP/CP residency

P A G E 1 7

Medical Student Update

Humberto Trejo Bittar and Russ Silowash have been appointed as pathology medical student liaisons.

They have participated in the SOM MS-3 career night, the medical student research fair and the Alle-

gheny Medical Society Career night.

A brochure has been developed by the pathology medical student liaisons containing information on our

department medical student opportunities and electives.

Our MS-1 Pathobiology Course is seeking faculty workshop instructors for January 15th through January

23rd 2015. Please contact Dr. DeFrances if you are interested in being a workshop instructor.

Jeff Nine has received over 50 applications form MS-1 and MS-2 students for his Autopsy Discovery

program. He plans a lottery to take 30 students.

Christine Roth recently presented at the SOM Curriculum Committee highlighting findings from an arti-

cle she, Fiona Craig and others published this fall in Human Pathology [(2014) 45: 1985 – 1994] on

the creation of “The Virtual Pathology Instructor: a medical student teaching tool developed using

patient simulator software.”

Zahida Khan MD PhD, Donna B. Stolz PhD, David H. Perlmutter MD, and

George K. Michalopoulos MD PhD.

"Isolation and characterization of PAS+ globule-enriched hepatocyte subsets from a PiZ mouse model of

alpha-1 antitrypsin deficiency: Focus on liver progenitor cells.”

Pennsylvania Society for Gastroenterology Annual Scientific Meeting

Nemocolin Woodlands Resort, Farmington, PA; September 19-21, 2014

SECOND PRIZE - $500 FOR BEST POSTER

Trevor Macpherson, M.D., and Jennifer

Yoest receiving the Robert E. Lee

Pathology award at senior awards

program May, 2014.

Stacey Barron,M.D., a fourth

year AP/CP resident, married

Travis Miller on October 4,

2014 in Pittsburgh. Travis is an

investment portfolio analyst at

BNY Mellon. The couple resides

in Franklin Park. Congratulations!

P A G E 1 8

For the sixth straight year, UPMC's Pathology Medical Student Interest Group (PMSIG) has been awarded a

$1000 prize by the Intersociety Council for Pathology Information (ICPI). The prize money will be used to

support PMSIG's activities such as monthly lunch presentations by pathology faculty and residents which

inform medical students about training and research opportunities in pathology, the Pathology Autopsy Dis-

covery Program overseen by Dr. Jeff Nine which introduces first and second year students to the medical and

educational utility of the autopsy, and other student-led initiatives. Congratulations to this year's PMSIG stu-

dent leaders - Soma Jobagy (President), Terri Jones (Vice President) and Jackie Birkness (Secretary/

Treasurer)! Marie DeFrances, M.D., Ph.D.

PATHOLOGY SEMINARS January, - April, 2015

__________________________________________________

Wednesday, January 14, 2015 - noon

1104 Scaife Hall

“Implications of Molecular Advances in Thyroid Pathology”

Sylvia L. Asa, M.D., Ph.D.

Medical Director, Laboratory Medicine Program

University Health Network and Lakeridge Health

University of Toronto

_______________________________________________

Wednesday, January 21, 2015 - noon

1104 Scaife Hall

“How Autoimmunity Gets Started”

Mark Shlomchik, M.D., Ph.D.

Professor and Chair

Department of Immunology

University of Pittsburgh

______________________________________________

Wednesday, January 28, 2015 - noon

1104 Scaife Hall

“Emerging Immunologic Biomarkers in Surgical Pathology”

Janis M. Taube, M.D.,

Director, Dermatopathology Division

Assistant Professor, Dermatology, Pathology and Oncology

John Hopkins University

Baltimore, MD

______________________________________________

Wednesday, February 11, 2015- noon

1104 Scaife Hall

“Paneth Cell Phenotype in Crohn’s Disease Genetic and

Clinical Relevance”

Ta-Chiang Liu, M.D., Ph.D.

Assistant Professor

Washington University

School of Medicine

________________________________________________

ANNUAL MARTINEZ MEMORIAL LECTURE

Wednesday, February 18, 2015 - noon

Lecture Room 5 Scaife Hall

"Title: TBA

David Ellison, M.D., Ph.D.

Department of Pathology

St. Jude Children’s Research Hospital

Memphis, TN

Wednesday, February 25, 2015- noon

1104 Scaife Hall

“Epigenome Modification in the Pathophysiology of Phenylalanine

Intoxication”

Steven Dobrowolski, Ph.D.

Associate Professor of Pathology

Department of Pathology

Children’s Hospital

__________________________________________

Wednesday, March 4, 2015 - noon

1104 Scaife Hall

"Targeting Novel Androgen Axis Resistance Mechanisms for

DEvelopment of Next Generation Treatment Strategies”

Allen Gao, M.D., Ph.D.

Ralph de Vere White Professor

Director of Urologic Research

Co-Leader, Prostate Cancer Program

University of California Davis Comprehensive Cancer Center

Davis, CA

_____________________________________________

Wednesday, March 11, 2015- noon

1104 Scaife Hall

Title: TBA

Steven Gracheva, Ph.D.

Assistant Professor of Physiology

MSM School of Medicine

Yale University

New Haven, CT

______________________________________________

Wednesday, March 18, 2015- noon

1104 Scaife Hall

Title: TBA

Hao Zhu, M.D.

Children’s Medical Center Research Unit

University of Southwestern

Dallas, TX

____________________________________________

Wednesday, April 8, 2015- noon

1104 Scaife Hall

"Title: TBA

John Cijiang He, M.D.

Icahn School of Medicine at Mount Sinai

New York, NY

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