parkinson’s disease 101 an introduction - · pdf file1/8/2016 1 parkinson’s...
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1/8/2016 1
Parkinson’s Disease 101 An Introduction
Parkinson’s Disease 101: An Introduction
The Johns Hopkins Parkinson’s Disease Community
Outreach and Education Center A National Parkinson Foundation Center of Excellence
Susan Rebecca Dunlop RN, MS (Becky)
Associate Director, Johns Hopkins Parkinson’s Disease and Movement Disorders Center Instructor of Neurology
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Objectives
• Understand basic information about Parkinson’s Disease
• Recognize non-motor and psychological aspects of this complex illness
• Understand treatment options including medications and the value of a comprehensive team approach
• Understand the state of current research and the hope that research provides for those living with PD
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History of Parkinson’s Disease
• James Parkinson wrote “An Essay on the Shaking Palsy” in 1817
• Dopamine Deficiency discovered in 1960s • Levodopa first used successfully in 1961 • Between 1961 and 2015 additional medications
discovered and used in treatment • 1997 Surgical Treatment approved for individuals
with disabling tremor • 2002 Surgical Treatment approved for individuals
with advanced illness
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Essay on the Shaking Palsy by James Parkinson, M.D.
“…involuntary tremulous motion, with lessened muscular power, in parts not in action and even when
supported; with a propensity to bend the trunk forward, and to pass from a walking to a running pace; the senses
and intellect being uninjured.”
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Parkinson’s Disease
• A progressive, chronic, complex, neurological disorder
• Caused by the degeneration of cells that produce dopamine
• Dopamine is a Neurotransmitter (chemical messenger)
• Dopamine is produced by the cells within the Substantia Nigra (black substance)
• One of the few progressive neurological diseases whose symptoms can be alleviated with medications
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Dopamine System in Human Brain
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Neurotransmission
Nerve Cell
Nerve Cell
Axons
Synapse Dopamine
Dopamine is a chemical messenger or neurotransmitter which carries messages across the synapses from one nerve cell to the next
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Parkinson’s Disease vs. Parkinsonism
• Primary or Idiopathic Parkinson’s Disease • Secondary Parkinsonism • Parkinson Plus Syndromes • Heredodegenerative Disease
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Idiopathic
“Cause is Unknown”
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Theories of the Cause
Environmental Factors + Genetic Factors + Age ____________________ Parkinson’s Disease * The vast majority of individuals who develop
Parkinson’s Disease show no clear causative factor.
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Cause of Parkinson’s Disease
*Genetics *Environment
Pathogenesis
Oxidative Stress
Mitochondria Dysfunction Inflammation Protein
Aggregation Apoptosis Cascade
Parkinson’s Disease
“Parkinson’s Disease: The Life Cycle of the Dopamine Neuron”, The New York Academy of Sciences, 2003
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Incidence of Parkinson’s Disease
• Parkinson’s Disease affects about One Million Americans
• 50,000-60,000 Americans are diagnosed each year • Average age of onset is 55-65 years of age • 5-10% of patients are under the age of 40 • Present worldwide in all races and socioeconomic
groups • Slightly higher incidence in men
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Cardinal Signs & Symptoms
• Tremor • Rigidity • Bradykinesia • Impaired Balance
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Tremor
• Resting tremor • Localized to hands, feet, and or legs at rest • Occasional chin tremor • Described as pill rolling tremor in hands • 30% of those diagnoses do not have tremor • Unilateral early in the illness • May impact dominant or non-dominant side
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Rigidity
• Cogwheel Rigidity (a jerky movement felt by the physician on exam)
• Stiffness • Present in joints such as wrist, knee, neck,
elbow, etc.
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Bradykinesia
• Brady refers to slowness • Kinesia refers to movement • May be recognized by lack of armswing • Patient may complain that it takes longer to
complete tasks • May progress to Akinesia (no
movement)without medication
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Impaired Balance
• Unsteadiness or postural imbalance • Occurs much later in the illness if at all • Physician will assess balance with pull test • Hoehn and Yahr Staging used to describe
progression or stage of illness
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Hoehn and Yahr Staging
• Stage 0 – No signs of the disease
• Stage 1 – Unilateral Disease
• Stage 1.5 – Unilateral plus axial
• Stage 2 – Bilateral Disease
• Stage 2.5 – Bilateral Disease, Mild difficulty walking
• Stage 3 – Bilateral Disease, Moderate difficulty walking
• Stage 4- Bilateral Disease, Severe difficulty walking
• Stage 5 – Bilateral Disease, Unable to walk
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Secondary Signs & Symptoms
• Motor Disorders • Neuropsychological Disorders • Autonomic Disorders / Non-Motor
Disorders • Other, including Speech
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Motor Disorders
»Less Frequent Blinking »Micrographia (Small
Handwriting) »Stooped Posture »Shuffling Gait »Hypomimia (Mask Like Face
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Autonomic Disorders The Autonomic nervous system manages body functions as
digestion, hormones, temperature control, bowel and bladder functioning without us being aware.
• Constipation • Urinary Urgency, Frequency, Incontinence • Drooling • Heat Intolerance • Increased Perspiration • Dandruff • Excessive oiliness • Low Blood Pressure • Sexual Functional Problems
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Other Secondary Signs & Symptoms
• Fatigue • Speech and Swallowing Difficulties • Sleep Abnormalities • Vivid Dreams • Restless Legs Syndrone • Neuropsychological Problems
» Depression » Anxiety » Bradyphrenia (Slowness of thinking) » Dementia » Psychosis (Hallucinations and Delusions)
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Psychiatric Diagnoses Also Common Initial Psychiatric Diagnoses (n=117), PDRC Longitudinal Study
43%
22%
15%
9%
8% 0% 3%
Asymptomatic, n=38Depression, n=32Anxiety, n=13Psychosis, n=13Apathy, n=7Disinhibited n=4Not done, n=10
Marsh, 2001
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Progression of Parkinson’s Disease
• Slow • Varies from person to person • Secondary symptoms vary • Anticipate a normal life span • Minority go into Nursing Homes and reach
Stage 5 of Hoehn and Yahr
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Parkinson’s Disease Goal of Therapy
• Adequately control the symptoms when 1.Symptoms interfere with daily functioning 2.Symptoms contribute to embarassment • Individualize therapy • Treat the Secondary Signs and
Symptoms
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Treatment Options
• Medication • Rehabilitation therapies • Social work services • Complementary therapies • Surgery in select cases
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Medication
• Relieve symptoms • Most common starting medications:
– Dopamine agonists (Requip®, Mirapex®) – Levodopa/carbidopa (Sinemet®)
• Treatment is different for each person. • Response to medication is individual.
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Parkinson’s Disease Medications Mirapex Sinemet Apokyn
Requip Sinemet CR Amantadine
Azilect Tasmar Artane
Eldepryl Comtan Stalevo
Apokyn Parcopa Duopa
Rytary
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Individualized therapy involves not only the pharmacological and surgical management, but also the
appropriate use of allied health professionals, assistive
technologies, educational and support resources along the chronic illness continuum.
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PATIENT CENTERED CARE
Patient
Family Neurologist
Physical Therapist
Speech Therapist
Occupational Therapist
Nurse Practitioner
Nurse Primary Physician
Dietician
Psychiatrist
Counselor
Social Worker
Support Groups
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MAKE YOUR MANAGEMENT PLAN UNIQUE TO YOU !
YOU
Your Famil
y Dr.
Pontone
Arita McCoy
RN Dr. Mills
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Needs Vary with Stage of the Ilness
Honey period Motor complications Resistant symptoms Cognitive Decline Period
Onset
Dx Rx 3 Years 8 Years 15 Years
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Rehabilitation Therapy Physical Therapy Occupational Therapy Exercise instruction Activities of Daily Living Gait training Workplace adaptations Fall prevention Home Safety Speech Therapy -- loudness of voice, swallowing
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Social Work Services
• Help in getting social services, community resources and support
• Help with effects of Parkinson’s on the individual and family
• Support groups • Help in dealing with depression, anxiety and
other emotional changes
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Complementary Therapies • Music therapy • Art therapy • Therapeutic
horticulture • Aromatherapy • Animal-assisted
therapy • Yoga • Tai Chi
• Spiritual care • Massage • Healing touch • Stress management • Acupuncture
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• The entire family is affected. • Families can experience many emotional
changes. • Need education, support and resources • Caregiver support groups • Training on physical aspects of caregiving • Planning for the future
Family Experiences and Needs
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The Es of Empowered Living with Parkinson’s Disease
• Education • Exercise • Eating Well • Effective Communication • Effective Coping • Exploring Options
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HOPE That elusive spirit in the heart of man,
With it, desires and fears will withstand.
When present and believed within the soul,
The thread of hope will keep you whole.
Becky Dunlop RN (2009)
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Thanks to the Johns Hopkins Parkinson’s and Movement Disorder
Team Faculty • Zoltan Mari, M.D. • Ted Dawson, M.D., Ph.D. • Liana Rosenthal, M.D. • Gregory Pontone, M.D. • Kelly Mills, M.D. • Alexamder Pantelyat, M.D.
Adjunct Faculty • Howard Weiss, MD • Joseph Savitt, M.D., Ph.D. • Stephen Grill, M.D., Ph.D. • Shawn Smyth, M.D.
Allied Team • Arita McCoy, R.N., B.S.N. • Bailey Vernon, M.P.H., CHES
McCoy, R.N., B.S.N. Bailey Vernon, M.P.H.
Neurosurgeons • Fred Lenz, M.D. • William S. Anderson, M.D.
Additional Allied Team • Marsha Davis, R. D. • Jenn Millar, P.T. • Donna Tippett, M.P.H., M.A.,
CCC-SLP • Nicole Bonsavage • Katerina Salnikova
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Acknowledgments • Thanks to the following individuals who assisted in the
development of this presentation:
• Margaret Anne Coles, BSR, MQI, Barrow Neurological Institute, Phoenix, AZ • Carol Eickhorn, MSN, ARNP, CNOR, NPFCC Coordinator, North Ridge
Medical Center, Ft. Lauderdale, FL • Joan Gardner RN, BSN, NPF Coordinator, Struthers Parkinson Center,
Minneapolis, MN • Gladys Gonzalez-Ramos, Ph.D., New York University School of Social Work • Ruth Hagestuen, RN, MA, NPF National Field Services Director, Miami, FL • Monica Hubmann, ARNP, NPFCC Coordinator, Tallahassee Memorial
Parkinson Center, Tallahassee, FL • Gale Kittle, RN, MPH, Consultant, St. Joseph’s Hospital & Medical Center,
Phoenix, AZ • Sharon Metz, RN, MPH, NPFCC State Coordinator, West Palm Beach, FL • John Morgan, MD, Ph.D., Movement Disorder Specialist, Assistant Professor
of Neurology, Medical College of Georgia