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Diabetes Update
Pam Allweiss, MD, [email protected]
Centers for Disease Control and Prevention.
Division of Diabetes TranslationThe findings and conclusions of this presentation are those of the presenter and
do not necessarily represent views of the Centers for Disease Control and Prevention
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An American Epidemic
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Age-adjusted Percentage of U.S. Adults Who Were Obese or Who
Had Diagnosed Diabetes
Obesity (BMI 30 kg/m2)
Diabetes
1994
1994
2000
2000
No Data 26.0%
No Data 9.0%
CDCs Division of Diabetes Translation. National Diabetes Surveillance System available athttp://www.cdc.gov/diabetes/statistics
2009
2009
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26 millionwith Diabetes
79 million
withPre-Diabetes
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Epidemic of Diabetes
Diabetes affects almost 26 million Americans
(8.3%), one quarter of whom dont know they haveit.
Another 79 million Americans have pre-diabetes,which raises their risk of developing type 2 diabetes,heart disease, and stroke.
About 1.9 million new cases of diabetes were
diagnosed in people aged 20 or older in 2010.
www.yourdiabetesinfo.org www.DiabetesAtWork.org
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0
5
10
15
20
25
0
1
2
3
4
5
6
7
8
1958 61 64 67 70 73 76 79 82 85 88 91 94 97 00 03 06 09
N
umberwithDiabet
es(Millions)
Percentagew
ithDiabetes
Year
Percentage with Diabetes
Number with Diabetes
Number and Percentage of U.S. Population with Diagnosed Diabetes,19582010
CDCs Division of Diabetes Translation. National Diabetes Surveillance System
available athttp://www.cdc.gov/diabetes/statistics
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0
10
20
30
40
50
60
Men Women
Percent
Total Non-Hispanic WhiteNon-Hispanic Black Hispanic
Narayan et al, JAMA, 2003
Estimated lifetime risk of developing diabetes for
individuals born in the United States in 2000
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Source: 20052008 National Health and Nutrition Examination Survey.
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The Diabetes Epidemic
Aging of America
Diverse ethnic groups, various incidence andprevalence of diabetes
Earlier diagnosis and reclassification Pre-diabetes: Borderline Diabetes or a touch
of sugar = real condition that needs to betreated
By 2050, 1 in every 3 adult Americans willhave diabetes if current trends continue
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Estimated Cost of
Diabetes in U.S. (ADA 2007)
Total: $174 billion
Indirect costs include increased absenteeism ($2.6billion) and reduced productivity while at work
($20.0 billion) for the employed population Reduced productivity for those not in the labor
force ($0.8 billion)
Unemployment from disease-related disability
($7.9 billion) Lost productive capacity due to early mortality
($26.9 billion)
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Diabetes 101: What is Diabetes
Notjust a sugar problem Interaction of food, insulin, other hormones
(glucagon) Physical activity/Obesity
Pancreatic function Genetics
Other commonly associated conditions:hypertension, lipid problems
The complications, not just the diagnosis ofdiabetes, cause the problems
Diabetes is common, serious BUT treatable
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Diabetes means:
2 x the risk of high blood pressure
2 to 4 x the risk of heart disease
2 to 4 x the risk of stroke
#1 cause of adult blindness #1 cause of kidney failure Causes more than 60% of non-traumatic
lower-limb amputations each yearNIDDK, National Diabetes Statistics fact sheet. HHS, NIH, 2010.
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Complications
Eyes
Kidneys
Nerves
Cardiovascular disease and stroke
Randomly controlled studies show that these
complications can be prevented or controlled with
good blood sugar control but this might involvemultiple shots etc
More shots does not mean worse diabetes!
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Symptoms
Frequent urination
Excessive thirst
Extreme hunger or
constant eating
Unexplained weight loss
Presence of glucose in
the urine
Tiredness or fatigue
Changes in vision
Numbness or tingling in
the extremities Slow-healing wounds or
sores
Abnormally high
frequency of infection Many people have
no symptoms
Di i (Di b C 1 2010)
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Diagnosis (Diabetes Care 1-2010)
1) A1C 6.5%. (by lab using a method that is NGSP certified and
standardized to the DCCT assay.* (caveats: anemia, pregnancy)
OR
2) FPG 126 mg/dl (7.0 mmol/l). Fasting is defined as no caloric intake
for at least 8 h.*
OR
3) 2-h plasma glucose 200 mg/dl (11.1 mmol/l) during an OGTT. The
test described by the WHO, using a glucose load containing theequivalent of 75 g anhydrous glucose dissolved in water.*
OR
4. In a patient with classic symptoms of hyperglycemia or hyperglycemic
crisis, a random plasma glucose 200 mg/dl (11.1 mmol/l).
*In the absence of unequivocal hyperglycemia, criteria 13 should beconfirmed by repeat testing
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Types of Diabetes
Type 1: traditionally age 40, multiple problems withinsulin secretion and action, may be any age, about80-90% of people with diabetes, Rx may includeoral agents and/or insulin or newer agents(incretins, GLP1 )
Pre-diabetes
Gestational Diabetes
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Who Is At Risk? Age 45 or older
Overweight
Inactive
Ethnic or minoritypopulation
Family history of
diabetes Excess abdominal fat
High blood pressure
Pre-diabetes
High blood fats
Darkening of the skin
Polycystic ovary
syndrome
History of GestationalDiabetes or large baby
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Could You be at Risk for Diabetes?
Where do you start?
ADA Risk Test (paper or online)
www.diabetes.org
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Categories of increased risk for diabetes
(Pre-diabetes)
Impaired Fasting Glucose: FPG 100 mg/dl(5.6 mmol/l) to 125 mg/dl (6.9 mmol/l)
Impaired Glucose Tolerance: 2-h PG in the75-g OGTT : 140 mg/dl (7.8 mmol/l) - 199 mg/dl(11.0 mmol/l)
A1C 5.76.4%
For all three tests, risk is continuous, extending
below the lower limit of the range and becomingdisproportionately greater at higher ends of therange.
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Why Control Diabetes?
Do Any Interventions Work?
Bottom Line: Does better glucose control translateto better outcomes or better health in theindividual?
Yes! For every 1% drop in A1c the risk of microvascular
complications (eye, kidney, and nerve damage) canbe reduced by up to 40%.
http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2007.p
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Control the ABCS
A1c: Glucose control
Blood Pressure control
Cholesterol (lipid) control
Smoking cessation
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Glucose
Liver
Peripheral Tissues
(Muscle)
Pancreas
Receptor +
postreceptor defect
Increased glucose
production
Impairedinsulin
secretion
Insulin
resistance
P.23
Causes of Hyperglycemia in
Type 2 Diabetes
1997 PPS
C
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Source: 20072009 National Health Interview Survey.
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Physiologic Serum Insulin Secretion
Profile
Polonsky KS et al, N Engl J Med 1996.
75
50
25
0
PlasmaInsu
lin
(U/mL)
Time
4:00 8:00 12:00 16:00 20:00 24:00 28:00 32:00
Breakfast Lunch Dinner
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So what are some resources and
how can we use them?
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Where is the community partner?
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National Diabetes Education
Program CDC and NIH program formed after evidence showed that
better glucose control translated into fewer complications
Public and private partnerships to improve diabetes treatmentand outcomes
Increased public awareness of the seriousness of diabetes, its
risk factors, and strategies for preventing diabetic complications NDEP translates the latest science and spreads the word that
diabetes is serious, common, and costly, yet controllable and,for type 2,preventable
Focus group tested by diverse audiences, multiple languages
NO COPYRGHT : Add your logo! Over 200 public/private partnerships
www.yourdiabetesinfo.orgwww.ndep.nih.gov
http://www.ndep.nih.gov/http://www.ndep.nih.gov/http://www.ndep.nih.gov/http://www.ndep.nih.gov/http://www.ndep.nih.gov/ -
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NDEP Campaign Materials: Control &Prevention
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Different types of materials
Print Downloads
Podcasts
Videos
Promotion resources
Behavior change resources
PP Presentations such as: Diabetes: the
numbers, and Science of control
i l f
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Materials for Consumers
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Content
Healthy eating/ how to eat out/tasty recipes
Take care of your feet/Be smart about your
heart
Team care
Tips to stay healthy
Know your numbers
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4 Steps to control your diabetes
brochure
Also available in these languages:
Bengali, Cambodian, Chinese, Gujarati, Haitian
Creole (and CD), Hindi, Hmong, Japanese,
Korean, Laotian, Samoan, Spanish, Tagalog,
Thai, Tongan, Urdu, Vietnamese
Materia s or Pro essiona s an Lay
http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=179http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=18http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=21http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=135http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=163http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=163http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=141http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=139http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=136http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=22http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=134http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=25http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=42http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=19http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=20http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=23http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=180http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=24http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=24http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=180http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=23http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=20http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=19http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=42http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=25http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=134http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=22http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=136http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=139http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=141http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=163http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=163http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=135http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=21http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=18http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=179 -
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Materia s or Pro essiona s an LayWorkers
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The Road to Health/El Camino
Hacia La Buena SaludCHW Primary
prevention toolkit
The Road to Health (RTH) Toolkit/ El camino hacia la buena salud Toolkit :
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The Road to Health (RTH) Toolkit/ El camino hacia la buena salud Toolkit :
AToolkit on Primary Prevention of Type 2 Diabetes for Community Health
Workers (CHWs)/Promotores
The Road to Health Toolkit was developed based on
the findings from the Diabetes Prevention Program(DPP) study and focus groups with African Americanand Hispanic/Latino Community Health Workers.
Focus groups with CHWs from urban and ruralAfrican American and Hispanic/Latino
communities: Diabetes testing, management, and prevention
strategies Barriers, opportunities, perceptions Focus on primary prevention Tools needed Training video
NDEP Websites
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NDEP Websites
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www.diabetesatwork.org Content
General Diabetes Education :
Nutrition, Weight Control, and Physical Activity
Lunch and Learn topics
Lesson Plans (English and Spanish)
Fact Sheets (English and Spanish)
Guide to choosing a health plan, developed with AAHP
Supervisors guide
NO COPYRIGHT!
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Fotonovela: Do it for them! But for you too.
(Hazlo por ellos! Pero por ti tambin.)
This fotonovela is a bilingual (Spn/Eng)fotonovela featuring dramatic stories of Latinas
talking to Latinas about preventing or delaying
type 2 diabetes and being healthy for their
children and themselves.
The stories use three womens challenges in
maintaining a healthy lifestyle to convey an
important message:
Increasing physical activity,
making healthy food choices and
losing weight (if you are overweight)
decreases or delays your risk of developing
type 2 diabetes.
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Tasty Recipes for People with Diabetes and Their Families
(Ricas recetas para personas con diabetes y sus familiares)
A bilingual booklet, Tasty Recipes is
filled with recipes specifically
designed for Latin Americans.
Recipes are accompanied by their
nutritional facts table. The bookletalso includes diabetes health
information and resources.
This effective, yet practical,
educational promotional tool is a
terrific addition to any kitchen.
http://www.ndep.nih.gov/publications/PublicationDetail.aspx?PubId=143http://ndep.nih.gov/media/diabetes-recipe-spanish-omelet.pdfhttp://www.ndep.nih.gov/publications/PublicationDetail.aspx?PubId=131 -
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Words of Wisdom
Cant transform everything at once
Use the web sites to print out forms and
recipes
Dont re-invent the wheel
Learn from others
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The Diabetes Prevention Program (DPP): The New
Frontier: Lifestyle Modifications or Medication
Goal: To prevent or delay the development of type 2 diabetes in personswith impaired glucose tolerance (IGT)
High-risk individuals with IGT and elevated FPG (N=3234) randomized to
Placebo
Intensive lifestyle intervention; at least monthly contact with case
managers
Metformin titrated to 850 mg bid
Reduction at 2.8 years
58% in the intensive lifestyle intervention group 31% in the metformin group
The Diabetes Prevention Program Research Group. Diabetes Care. 1999;22:623.
NIDDK. http://www.niddk.nih.gov/welcome/releases/8_8_01.htm.
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National Diabetes Prevention Program
Goal:
Systematically scale the translated model of theDiabetes Prevention Program (DPP) for high riskpersons in collaboration with community-basedorganizations that have necessary infrastructure,health payers, health care professionals, publichealth, academia, and others to reduce theincidence of type 2 diabetes in the United States.
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National Diabetes Prevention Program
Training = CDC contracted with Emory University to
establish the Diabetes Training and Technical
Assistance Center (DTTAC) and developed Master
Trainer curriculum and unified Lifestyle Coachcurriculumwww.dttac.org.
Recognition Program = CDC and partners developed
the standards for program recognition
For more information:http://www.cdc.gov/diabetes/prevention/
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www.cdc.gov/diabetes/prevention
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How do I get NDEP materials?
All NDEP materials are
copyright-free.Download from
www.yourdiabetesinfo.org
Visit all of the NDEP Websites:
www.ndep.nih.gov
www.betterdiabetescare.nih.gov
www.cdc.gov/diabetes/ndep
www.diabetesatwork.org
http://www.yourdiabetesinfo.org/http://www.ndep.nih.gov/http://www.betterdiabetescare.nih.gov/http://www.cdc.gov/diabetes/ndephttp://www.diabetesatwork.org/http://www.diabetesatwork.org/http://www.cdc.gov/diabetes/ndephttp://www.betterdiabetescare.nih.gov/http://www.ndep.nih.gov/http://www.yourdiabetesinfo.org/