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    Diabetes Update

    Pam Allweiss, MD, [email protected]

    Centers for Disease Control and Prevention.

    Division of Diabetes TranslationThe findings and conclusions of this presentation are those of the presenter and

    do not necessarily represent views of the Centers for Disease Control and Prevention

    mailto:[email protected]:[email protected]:[email protected]
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    An American Epidemic

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    Age-adjusted Percentage of U.S. Adults Who Were Obese or Who

    Had Diagnosed Diabetes

    Obesity (BMI 30 kg/m2)

    Diabetes

    1994

    1994

    2000

    2000

    No Data 26.0%

    No Data 9.0%

    CDCs Division of Diabetes Translation. National Diabetes Surveillance System available athttp://www.cdc.gov/diabetes/statistics

    2009

    2009

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    26 millionwith Diabetes

    79 million

    withPre-Diabetes

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    Epidemic of Diabetes

    Diabetes affects almost 26 million Americans

    (8.3%), one quarter of whom dont know they haveit.

    Another 79 million Americans have pre-diabetes,which raises their risk of developing type 2 diabetes,heart disease, and stroke.

    About 1.9 million new cases of diabetes were

    diagnosed in people aged 20 or older in 2010.

    www.yourdiabetesinfo.org www.DiabetesAtWork.org

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    0

    5

    10

    15

    20

    25

    0

    1

    2

    3

    4

    5

    6

    7

    8

    1958 61 64 67 70 73 76 79 82 85 88 91 94 97 00 03 06 09

    N

    umberwithDiabet

    es(Millions)

    Percentagew

    ithDiabetes

    Year

    Percentage with Diabetes

    Number with Diabetes

    Number and Percentage of U.S. Population with Diagnosed Diabetes,19582010

    CDCs Division of Diabetes Translation. National Diabetes Surveillance System

    available athttp://www.cdc.gov/diabetes/statistics

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    0

    10

    20

    30

    40

    50

    60

    Men Women

    Percent

    Total Non-Hispanic WhiteNon-Hispanic Black Hispanic

    Narayan et al, JAMA, 2003

    Estimated lifetime risk of developing diabetes for

    individuals born in the United States in 2000

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    Source: 20052008 National Health and Nutrition Examination Survey.

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    The Diabetes Epidemic

    Aging of America

    Diverse ethnic groups, various incidence andprevalence of diabetes

    Earlier diagnosis and reclassification Pre-diabetes: Borderline Diabetes or a touch

    of sugar = real condition that needs to betreated

    By 2050, 1 in every 3 adult Americans willhave diabetes if current trends continue

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    Estimated Cost of

    Diabetes in U.S. (ADA 2007)

    Total: $174 billion

    Indirect costs include increased absenteeism ($2.6billion) and reduced productivity while at work

    ($20.0 billion) for the employed population Reduced productivity for those not in the labor

    force ($0.8 billion)

    Unemployment from disease-related disability

    ($7.9 billion) Lost productive capacity due to early mortality

    ($26.9 billion)

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    Diabetes 101: What is Diabetes

    Notjust a sugar problem Interaction of food, insulin, other hormones

    (glucagon) Physical activity/Obesity

    Pancreatic function Genetics

    Other commonly associated conditions:hypertension, lipid problems

    The complications, not just the diagnosis ofdiabetes, cause the problems

    Diabetes is common, serious BUT treatable

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    Diabetes means:

    2 x the risk of high blood pressure

    2 to 4 x the risk of heart disease

    2 to 4 x the risk of stroke

    #1 cause of adult blindness #1 cause of kidney failure Causes more than 60% of non-traumatic

    lower-limb amputations each yearNIDDK, National Diabetes Statistics fact sheet. HHS, NIH, 2010.

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    Complications

    Eyes

    Kidneys

    Nerves

    Cardiovascular disease and stroke

    Randomly controlled studies show that these

    complications can be prevented or controlled with

    good blood sugar control but this might involvemultiple shots etc

    More shots does not mean worse diabetes!

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    Symptoms

    Frequent urination

    Excessive thirst

    Extreme hunger or

    constant eating

    Unexplained weight loss

    Presence of glucose in

    the urine

    Tiredness or fatigue

    Changes in vision

    Numbness or tingling in

    the extremities Slow-healing wounds or

    sores

    Abnormally high

    frequency of infection Many people have

    no symptoms

    Di i (Di b C 1 2010)

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    Diagnosis (Diabetes Care 1-2010)

    1) A1C 6.5%. (by lab using a method that is NGSP certified and

    standardized to the DCCT assay.* (caveats: anemia, pregnancy)

    OR

    2) FPG 126 mg/dl (7.0 mmol/l). Fasting is defined as no caloric intake

    for at least 8 h.*

    OR

    3) 2-h plasma glucose 200 mg/dl (11.1 mmol/l) during an OGTT. The

    test described by the WHO, using a glucose load containing theequivalent of 75 g anhydrous glucose dissolved in water.*

    OR

    4. In a patient with classic symptoms of hyperglycemia or hyperglycemic

    crisis, a random plasma glucose 200 mg/dl (11.1 mmol/l).

    *In the absence of unequivocal hyperglycemia, criteria 13 should beconfirmed by repeat testing

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    Types of Diabetes

    Type 1: traditionally age 40, multiple problems withinsulin secretion and action, may be any age, about80-90% of people with diabetes, Rx may includeoral agents and/or insulin or newer agents(incretins, GLP1 )

    Pre-diabetes

    Gestational Diabetes

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    Who Is At Risk? Age 45 or older

    Overweight

    Inactive

    Ethnic or minoritypopulation

    Family history of

    diabetes Excess abdominal fat

    High blood pressure

    Pre-diabetes

    High blood fats

    Darkening of the skin

    Polycystic ovary

    syndrome

    History of GestationalDiabetes or large baby

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    Could You be at Risk for Diabetes?

    Where do you start?

    ADA Risk Test (paper or online)

    www.diabetes.org

    http://www.diabetes.org/http://www.diabetes.org/
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    Categories of increased risk for diabetes

    (Pre-diabetes)

    Impaired Fasting Glucose: FPG 100 mg/dl(5.6 mmol/l) to 125 mg/dl (6.9 mmol/l)

    Impaired Glucose Tolerance: 2-h PG in the75-g OGTT : 140 mg/dl (7.8 mmol/l) - 199 mg/dl(11.0 mmol/l)

    A1C 5.76.4%

    For all three tests, risk is continuous, extending

    below the lower limit of the range and becomingdisproportionately greater at higher ends of therange.

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    Why Control Diabetes?

    Do Any Interventions Work?

    Bottom Line: Does better glucose control translateto better outcomes or better health in theindividual?

    Yes! For every 1% drop in A1c the risk of microvascular

    complications (eye, kidney, and nerve damage) canbe reduced by up to 40%.

    http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2007.p

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    Control the ABCS

    A1c: Glucose control

    Blood Pressure control

    Cholesterol (lipid) control

    Smoking cessation

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    Glucose

    Liver

    Peripheral Tissues

    (Muscle)

    Pancreas

    Receptor +

    postreceptor defect

    Increased glucose

    production

    Impairedinsulin

    secretion

    Insulin

    resistance

    P.23

    Causes of Hyperglycemia in

    Type 2 Diabetes

    1997 PPS

    C

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    Source: 20072009 National Health Interview Survey.

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    Physiologic Serum Insulin Secretion

    Profile

    Polonsky KS et al, N Engl J Med 1996.

    75

    50

    25

    0

    PlasmaInsu

    lin

    (U/mL)

    Time

    4:00 8:00 12:00 16:00 20:00 24:00 28:00 32:00

    Breakfast Lunch Dinner

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    So what are some resources and

    how can we use them?

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    Where is the community partner?

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    National Diabetes Education

    Program CDC and NIH program formed after evidence showed that

    better glucose control translated into fewer complications

    Public and private partnerships to improve diabetes treatmentand outcomes

    Increased public awareness of the seriousness of diabetes, its

    risk factors, and strategies for preventing diabetic complications NDEP translates the latest science and spreads the word that

    diabetes is serious, common, and costly, yet controllable and,for type 2,preventable

    Focus group tested by diverse audiences, multiple languages

    NO COPYRGHT : Add your logo! Over 200 public/private partnerships

    www.yourdiabetesinfo.orgwww.ndep.nih.gov

    http://www.ndep.nih.gov/http://www.ndep.nih.gov/http://www.ndep.nih.gov/http://www.ndep.nih.gov/http://www.ndep.nih.gov/
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    NDEP Campaign Materials: Control &Prevention

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    Different types of materials

    Print Downloads

    Podcasts

    Videos

    Promotion resources

    Behavior change resources

    PP Presentations such as: Diabetes: the

    numbers, and Science of control

    i l f

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    Materials for Consumers

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    Content

    Healthy eating/ how to eat out/tasty recipes

    Take care of your feet/Be smart about your

    heart

    Team care

    Tips to stay healthy

    Know your numbers

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    4 Steps to control your diabetes

    brochure

    Also available in these languages:

    Bengali, Cambodian, Chinese, Gujarati, Haitian

    Creole (and CD), Hindi, Hmong, Japanese,

    Korean, Laotian, Samoan, Spanish, Tagalog,

    Thai, Tongan, Urdu, Vietnamese

    Materia s or Pro essiona s an Lay

    http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=179http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=18http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=21http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=135http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=163http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=163http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=141http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=139http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=136http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=22http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=134http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=25http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=42http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=19http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=20http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=23http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=180http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=24http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=24http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=180http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=23http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=20http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=19http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=42http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=25http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=134http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=22http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=136http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=139http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=141http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=163http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=163http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=135http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=21http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=18http://ndep.nih.gov/publications/PublicationDetail.aspx?PubId=179
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    Materia s or Pro essiona s an LayWorkers

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    The Road to Health/El Camino

    Hacia La Buena SaludCHW Primary

    prevention toolkit

    The Road to Health (RTH) Toolkit/ El camino hacia la buena salud Toolkit :

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    The Road to Health (RTH) Toolkit/ El camino hacia la buena salud Toolkit :

    AToolkit on Primary Prevention of Type 2 Diabetes for Community Health

    Workers (CHWs)/Promotores

    The Road to Health Toolkit was developed based on

    the findings from the Diabetes Prevention Program(DPP) study and focus groups with African Americanand Hispanic/Latino Community Health Workers.

    Focus groups with CHWs from urban and ruralAfrican American and Hispanic/Latino

    communities: Diabetes testing, management, and prevention

    strategies Barriers, opportunities, perceptions Focus on primary prevention Tools needed Training video

    NDEP Websites

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    NDEP Websites

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    www.diabetesatwork.org Content

    General Diabetes Education :

    Nutrition, Weight Control, and Physical Activity

    Lunch and Learn topics

    Lesson Plans (English and Spanish)

    Fact Sheets (English and Spanish)

    Guide to choosing a health plan, developed with AAHP

    Supervisors guide

    NO COPYRIGHT!

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    Fotonovela: Do it for them! But for you too.

    (Hazlo por ellos! Pero por ti tambin.)

    This fotonovela is a bilingual (Spn/Eng)fotonovela featuring dramatic stories of Latinas

    talking to Latinas about preventing or delaying

    type 2 diabetes and being healthy for their

    children and themselves.

    The stories use three womens challenges in

    maintaining a healthy lifestyle to convey an

    important message:

    Increasing physical activity,

    making healthy food choices and

    losing weight (if you are overweight)

    decreases or delays your risk of developing

    type 2 diabetes.

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    Tasty Recipes for People with Diabetes and Their Families

    (Ricas recetas para personas con diabetes y sus familiares)

    A bilingual booklet, Tasty Recipes is

    filled with recipes specifically

    designed for Latin Americans.

    Recipes are accompanied by their

    nutritional facts table. The bookletalso includes diabetes health

    information and resources.

    This effective, yet practical,

    educational promotional tool is a

    terrific addition to any kitchen.

    http://www.ndep.nih.gov/publications/PublicationDetail.aspx?PubId=143http://ndep.nih.gov/media/diabetes-recipe-spanish-omelet.pdfhttp://www.ndep.nih.gov/publications/PublicationDetail.aspx?PubId=131
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    Words of Wisdom

    Cant transform everything at once

    Use the web sites to print out forms and

    recipes

    Dont re-invent the wheel

    Learn from others

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    The Diabetes Prevention Program (DPP): The New

    Frontier: Lifestyle Modifications or Medication

    Goal: To prevent or delay the development of type 2 diabetes in personswith impaired glucose tolerance (IGT)

    High-risk individuals with IGT and elevated FPG (N=3234) randomized to

    Placebo

    Intensive lifestyle intervention; at least monthly contact with case

    managers

    Metformin titrated to 850 mg bid

    Reduction at 2.8 years

    58% in the intensive lifestyle intervention group 31% in the metformin group

    The Diabetes Prevention Program Research Group. Diabetes Care. 1999;22:623.

    NIDDK. http://www.niddk.nih.gov/welcome/releases/8_8_01.htm.

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    National Diabetes Prevention Program

    Goal:

    Systematically scale the translated model of theDiabetes Prevention Program (DPP) for high riskpersons in collaboration with community-basedorganizations that have necessary infrastructure,health payers, health care professionals, publichealth, academia, and others to reduce theincidence of type 2 diabetes in the United States.

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    National Diabetes Prevention Program

    Training = CDC contracted with Emory University to

    establish the Diabetes Training and Technical

    Assistance Center (DTTAC) and developed Master

    Trainer curriculum and unified Lifestyle Coachcurriculumwww.dttac.org.

    Recognition Program = CDC and partners developed

    the standards for program recognition

    For more information:http://www.cdc.gov/diabetes/prevention/

    http://www.dttac.org/http://www.dttac.org/
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    www.cdc.gov/diabetes/prevention

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    How do I get NDEP materials?

    All NDEP materials are

    copyright-free.Download from

    www.yourdiabetesinfo.org

    Visit all of the NDEP Websites:

    www.ndep.nih.gov

    www.betterdiabetescare.nih.gov

    www.cdc.gov/diabetes/ndep

    www.diabetesatwork.org

    http://www.yourdiabetesinfo.org/http://www.ndep.nih.gov/http://www.betterdiabetescare.nih.gov/http://www.cdc.gov/diabetes/ndephttp://www.diabetesatwork.org/http://www.diabetesatwork.org/http://www.cdc.gov/diabetes/ndephttp://www.betterdiabetescare.nih.gov/http://www.ndep.nih.gov/http://www.yourdiabetesinfo.org/