P21—Assessment, remediation and risk assessment of perfluorinated chemicals at 2 former fire training areas

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  • Abstracts / Reproductive Toxicology 33 (2012) 129 9

    P20The toxicokinetics of various peruorinated alkyl chemi-cals in the Harlan Spraque-Dawley rat

    Chad R. Blystone , Veronica G. Robinson, Cynthia S. Smith, Ron L.Melnick, Kr

    National ToUnited State

    The toxivary greatlysexes, andrisk assessmmetrics. Thity evaluatitoxicokinet(PFBS), peruorooctanperuoroocin male andcharacterizdose (threewith 2% Tw(n=3/timespectroscoptwo compaand eliminarats for PFOdifference pshorter chawhile PFOSrats, PFHxAthese chemvide guidanand assist t


    P21Assesrinated che

    Ian Chatwe

    Transport C

    Transpoareas (FTAsused for remerly inclua fuelling sdistributionthe aircrafttraining exeFilm Formin

    It has beAFFF wereAccording tproducts aring water ((1020%), a(0.11%), trresidual orgof the appliipated thatFTAs over th

    Environm(PFCs) at thand July 20

    plant tissue, and small mammal tissue were collected from the Siteand analyzed for PFCs. In addition to characterizing and delineatingPFCs contamination, site-specic risk based soil and groundwa-ter remedial targets were derived for PFOS and other PFCs. A soil

    g stuxtra

    e freeiate Ps of



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    rsityDaytnt EState

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    er merciamersutevided.S. Eis A. Thayer, Michael J. DeVito

    xicology Program, NIEHS, Research Triangle Park, NC,s

    cokinetic properties of peruorinated alkyl chemicalsdue to differences in elimination rates across species,

    chain length, which makes comparative toxicity andents across the class difcult when using external dose

    e National Toxicology Program is undertaking a toxic-on of the peruorinated chemicals class and conductedic studies of peruorobutane sulfonate potassium saltuorohexane sulfonate potassium salt (PFHxS), per-e sulfonate (PFOS), peruorohexanoic acid (PFHxA),tanoic acid (PFOA), and peruorodecanoic acid (PFDA)female Harlan Sprague-Dawley rats (89 wks old) to

    e the kinetics in this animal model. A single IV or oralconcentrations) was administered in deionized watereen 80. At varying time points plasma concentrationspoint) were determined by chromatography with massy (LCMS/MS). Data sets were evaluated using one orrtmental models (WinNonlin). As expected, the half lifetion rates was shorter and faster respectively in femaleA. PFHxA, PFBS, and PFHxS also displayed a similar sexattern while PFOS and PFDA did not. In both sexes, theined PFBS and PFHxS were eliminated quickly (hours)and PFDA had much longer (weeks) half lives. In femaledisplayed biphasic elimination. The bioavailability foricals was generally around 100%. These data will pro-ce for dose selection in theNTP class toxicity evaluationhe risk assessment for this chemical class.


    sment, remediation and risk assessment of peruo-micals at 2 former re training areas


    anada, Vancouver, British Columbia, Canada

    rt Canada historically operated two former re training) in central British Columbia, Canada. FTAs 1 and 2 were-ghter training between 1972 and 1992. Each FTA for-ded an aircraft mockup (comprised culvert sections),tation (above ground fuel storage and pump) and fuellines. The re training exercises consisted of ooding

    mockupswith fuel, igniting the fuel and conducting rercises using re suppression products such as Aqueousg Foam (AFFF), Super K and Purple K.en estimated that at least 2000 litres (L) and 2700L ofconsumed annually at FTA 1 and FTA 2, respectively.o various Material Safety Data Sheets (MSDS), AFFFe reported to contain a variety of substances includ-6585%), urea (37%), diethylene glycol butyl etherlkyl sulphate salts (15%), peruoroalkyl sulfonate saltsiethanolamine (0.11%), uoroalkylamides (2%) andanic uorochemicals (