p21 mechanism slide
TRANSCRIPT
G1 M
S
G2
R
p53
Direct p21 transcription
Inactive CDK T P
T-loop
ATP 161 14 CDK
PSTAIRE NH2 T Y 15
p21
G1 Arrest
Cell cycle arrest mediated by p53 target p21 (WAF1)
DNA damage
El-Deiry et al., Cell 75:817, 1993
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