p21 mechanism slide

1
G1 M S G2 R p53 Direct p21 transcription Inactive CDK T P T-loop ATP 161 14 CDK PSTAIRE NH 2 T Y 15 p21 G1 Arrest Cell cycle arrest mediated by p53 target p21 (WAF1) DNA damage El-Deiry et al., Cell 75:817, 1993 5,934 citations as of 4-13 The most highly cited original MS in Cell

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Page 1: p21 mechanism slide

G1 M

S

G2

R

p53

Direct p21 transcription

Inactive CDK T P

T-loop

ATP 161 14 CDK

PSTAIRE NH2 T Y 15

p21

G1 Arrest

Cell cycle arrest mediated by p53 target p21 (WAF1)

DNA damage

El-Deiry et al., Cell 75:817, 1993

5,934 citations as of 4-13 The most highly cited original MS in Cell