oxidative decarboxylation
DESCRIPTION
Oxidative Decarboxylation. Oxidative Decarboxylation. Oxidative Decarboxylation. Pyruvate is converted into acetyl- CoA in order to be brought into the mitochondria. Oxidative Decarboxylation. rxn type: decarboxylation redox synthesis enzyme: decarboxylase dehydrogenase - PowerPoint PPT PresentationTRANSCRIPT
Oxidative Decarboxylation
Oxidative Decarboxylation
Oxidative DecarboxylationPyruvate is converted into acetyl-CoA in order to be
brought into the mitochondria.
Oxidative Decarboxylationrxn type: decarboxylation
redox
synthesis
enzyme: decarboxylase
dehydrogenase
synthase
energy: released
Coenzyme ACoenzyme A is a large
organic molecule.
The active functional group is a thiol.
It is also written as
CoA-SH.
Oxidative Decarboxylation Summary
1. 2 pyruvate 2 acetyl-CoA
2. 2 CO2 released
3. 2 NADH produced
Kreb Cycle
Krebs Cycle
Krebs Cycle Overview
Krebs cycle is a cyclical process to:
1. produce additional CO2 molecules
2. generate more high energy molecules (NADH, FADH2 and ATP)
Also known as the citric acid cycle and the tricarboxylic acid cycle (TCA).
Krebs Cycle
Krebs Cycle: Step by StepStep 1:join 2 carbon molecule
with a 4 carbon molecule
rxn type: synthesis
enzyme: synthase
energy: absorbed
Krebs Cycle: Step by StepStep 2:rearrangement of atoms
with the help of H2O
rxn type: isomerization
enzyme: isomerase
energy: equivalent
Krebs Cycle: Step by StepStep 3:synthesis of CO2 and
NADH
rxn type: decarboxylation
redox
enzyme: decarboxylase
dehydrogenase
energy: released
Krebs Cycle: Step by StepStep 4:CO2 release and energy
molecule formation
rxn type: decarboxylation
redox
synthesis
enzyme: decarboxylase
dehydrogenase
synthase
energy: released
Krebs Cycle: Step by StepStep 5:ADP phosphorylation to ATP
rxn type: substrate-level phosphorylation
cleavage
enzyme: kinase
lyase
energy: released
Krebs Cycle: Step by StepStep 6:FADH2 (energy molecule)
formation
rxn type: redox
enzyme: dehydrogenase
energy: released
FAD / FADH2
FAD – flavin adenine dinucleotide (oxidized form)
FADH2 – flavin adenine dinucleotide (reduced form)
Krebs Cycle: Step by StepStep 7:rearranging the
molecule for the next reaction
rxn type: hydration
enzyme: hydrase
energy: absorbed
Krebs Cycle: Step by StepStep 8:energy molecule
formation & recreating molecules for Krebs cycle
rxn type: redox
enzyme: dehydrogenase
energy: released
Krebs Cycle Summary1. two cycles of Krebs for EACH glucose molecule
2. acetyl-CoA oxaloacetate (per cycle)
3. 2 CO2 released (per cycle)
4. 3 NADH produced (per cycle)
5. 1 FADH2 produced (per cycle)
6. 1 ATP produced (per cycle)
Krebs Cycle: Big Picture Perspective
Many of the components of Krebs cycle are used in many other types of metabolic processes.