PATHOGENESISCLINICAL FEATURES

Increase collagen deposition and

decreased fibrinolysis

Increase in cytokines, IL-6 TNF,IF increase in growth

factor TGF

Activated T cell and macrophage

at the site

Areca nut alkaloids catechins and tannin

Oral mucosa stage1

stage3

Stage 2

Restricted mouth opening 66% with sunken cheeks

Restricted tongue movements

Mild blanching Moderate blanching

Involving pterygo mandibular raphe increases trismus