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PATHOGENESISCLINICAL FEATURES
Increase collagen deposition and
decreased fibrinolysis
Increase in cytokines, IL-6 TNF,IF increase in growth
factor TGF
Activated T cell and macrophage
at the site
Areca nut alkaloids catechins and tannin
Oral mucosa stage1
stage3
Stage 2
Restricted mouth opening 66% with sunken cheeks
Restricted tongue movements
Mild blanching Moderate blanching
Involving pterygo mandibular raphe increases trismus