oral nutrisi rd final
DESCRIPTION
lTRANSCRIPT
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Islammiyah DY1), Wistiani1), Galuh H1)
1) Department of Pediatric, Faculty of Medicine, Diponegoro University, Kariadi Hospital, Semarang, Indonesia
Correlation between clinical manifestations and anti ds-DNA of patients with systemic lupus
erythematosus
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BACKGROUNDBACKGROUND
Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease with many clinical manifestations.
Anti ds-DNA antibody is a specific marker for this disease and correlate with disease activity.
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OBJECTIVE
to determine the relationship between clinical manifestations and anti ds-DNA.
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METHODS
Retrospective study Using medical records in Kariadi Hospital between January
2010 and June 2015 was done. Twenty six patients, age range 7-17 years old, were enrolled. Clinical features observed based on the American College of
Rheumatology criteria for SLE. Anti ds-DNA level was classified into ≤ 300 IU/ml and > 300 IU/ml.
Normality of data was analyzed by Shapiro-wilk. Statistic analysis was performed using exact fischer test.
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Subject characteristic
Characteristic Deathn (%)
Surviven (%)
Totaln (%)
GenderFemale
Male
3 (11,54)
0 (0)
20 (76,92)3 (11,54)
23 (88,46)3 (11,54)
AgePrepuberty
Puberty
0 (0)
3 (11,54)
3 (11,54)20 (76,92)
3 (11,54)23 (88,46)
SeveritySevere
Mild
1 (3,85)2 (7,69)
10 (38,46)
13 (50)
11 (42,31)15 (57,69)
Antibody anti ds-DNA
PositifNegatif
1 (3,85)
0 (0)
14 (53,85)5 (19,23)
15 (57,69)5 (19,23)
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Clinical description of pediatric with LES based on ACR Criteria Clinical Symptom Death
n(%)Surviven (%)
Totaln (%)
Malar rash 0 (0) 14 (53,85) 14 (53,85) discoid rash 2 (7,69) 12 ( 46,15) 14 (53,85)Fotosensitivity 1 (3,85) 14 (53,86) 15 (57,69)Mouth ulcer 2 (7,69) 4 (15,38) 6 (23,08)Artritis 1 (3,85) 11 (42,31) 12 (46,15)Serositis 2 (7,69) 7 (26,92) 9 (34,62) Kidney disturbance 2 (7,69) 15 (57,69) 17 (65,38)Nerves disturbance 0 (0) 1 (3,85) 1(3,85)Blood disturbance 2 (7,69) 21 (80,77) 23 (88,46)Immunology disturbance
1 (3,85) 13 (50) 14 (53,86)
Positif Antibody antinuklear
0 (0) 12 (46,15) 12 (46,15)
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Laboratory finding of pediatric with LES based on ACR Criteria
Blood Screening Result
Mean Value
Haemoglobin
8,92 gr/dL
Leucocyte 7.705,5 /mL
Trombocyte 210.877 /mL
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Clinical and laboratory description of pediatric with LES based on ACR Criteria
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Clinical and laboratory description of pediatric with LES based on ACR Criteria
This study was dominated by female patients 24 (92,3%), mean age of onset was ( 7.8 ± 4.6 SD ) years.
The frequency of clinical manifestation were haematologic disorder (eg anemia, leukopenia, and thrombocytopenia) 23 (88,5%), nephritis lupus 17 (65,4%), photosensitivity 15 (57,7%), malar rash and discoid rash 15 (53,8%), ANA positive 12 (46,15%), arthritis 12 (46,15%), serositis 9 (34,62%), oral ulcer 6 (23,08%) and transverse mielitis 1(3,85%).
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Clinical characteristic dan anti ds-DNA corelation in LES pediatric patient
(*) : exact Fischer test There was no correlation found between clinical manifestations and anti ds-DNA (p >0,05).
Laboratory findings
ds-DNA Reaktif
pNo Yes
n % n %
Anemia
No 1 33,3 2 66,70,404
Yes 2 11,8 15 88,2 Leucopeni
No 2 18,2 9 81,81,000
Yes 1 11,1 8 88,9
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(*) : exact Fischer test
Clinical characteristic dan anti ds-DNA corelation in LES pediatric patient
There was no correlation found between clinical manifestations and anti ds-DNA (p >0,05).
Pemeriksaan Laboratorium
ds-DNA Reaktif
pTidak Ya
n % n %
Trombositopeni
Tidak 3 17,8 14 82,41,00
0Ya 0 0 3 100
Proteinuria
Tidak 2 25 6 750,53
7Ya 1 8,3 11 91,7
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Karakteristik seluruh subyek penelitian sebelum intervensi
(*) : exact Fischer test
Clinical characteristic dan anti ds-DNA corelation in LES pediatric patient
There was no correlation found between clinical manifestations and anti ds-DNA (p >0,05).
Variabelds-DNA Reaktif
pTidak YaN % n %
Ruam malar Tidak 1 12,5 7 87,5 0,603Ya 4 33,3 8 66,7
Bercak discoid
Tidak 2 25 6 75 1,000Ya 3 25 9 75
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Karakteristik seluruh subyek penelitian sebelum intervensi
(*) : exact Fischer test
Clinical characteristic dan anti ds-DNA corelation in LES pediatric patient
There was no correlation found between clinical manifestations and anti ds-DNA (p >0,05).
Variabelds-DNA Reaktif
pTidak YaN % n %
Ulkus mulut Tidak 5 31,3 11 68,8 0,530Ya 0 0 4 100
Arthritis Tidak 2 20 8 80 1,000Ya 3 30 7 70
Serositis Tidak 5 38,5 8 61,5 0,114Ya 0 0 7 100
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Karakteristik seluruh subyek penelitian sebelum intervensi
(*) : exact Fischer test
Clinical characteristic dan anti ds-DNA corelation in LES pediatric patient
There was no correlation found between clinical manifestations and anti ds-DNA (p >0,05).
Variabelds-DNA Reaktif
pTidak YaN % n %
Gangguan ginjal
Tidak 2 28,6 5 71,4 1,000Ya 3 23,1 10 76,9
Gangguan saraf
Tidak 4 21,1 15 78,9 0,250Ya 1 100 0 0
Gangguan darah
Tidak 1 100 0 0 0,250Ya 4 21,1 15 78,9
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CONCLUSION
There was no correlation found between clinical manifestations and anti ds-DNA..
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