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    Patients Profile

    Case No.:23832

    Name: C.B

    Age: 28

    Address: Poblacion Bontoc, Mountain Province

    Gender: Male

    Pre-op diagnosis: Multiple Cholelitiasis

    Post-op diagnosis: Multiple Cholelitiasis

    Operation Performed: Open Cholecystectomy

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    Anatomy and Physiology:

    Gallbladder is a muscular organ that serves as a reservoir for

    bile, present in most vertebrates. In humans, it is a pear-

    shaped membranous sac on the undersurface of the right lobe of

    the liver just below the lower ribs. It is generally about 7.5

    cm (about 3 in) long and 2.5 cm (1 in) in diameter at its

    thickest part; it has a capacity varying from 1 to 1.5 fluid

    ounces. The body (corpus) and neck (collum) of the gallbladder

    extend backward, upward, and to the left. The wide end (fundus)

    points downward and forward, sometimes extending slightly beyond

    the edge of the liver. Structurally, the gallbladder consists of

    an outer peritoneal coat (tunica serosa); a middle coat of

    fibrous tissue and unstriped muscle (tunica muscularis); and an

    inner mucous membrane coat (tunica mucosa). The gallbladder lies

    in a shallow depression on the interior surface of the liver, to

    which it is attached by loose connective tissue. Its wall is

    composed largely of smooth muscle. The gallbladder is connected

    to the common bile duct by the cystic duct.

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    The function of the gallbladder is to store bile, secreted by

    the liver and transmitted from that organ via the cystic and

    hepatic ducts, until it is needed in the digestive process. The

    gallbladder, when functioning normally, releases bile through

    the biliary ducts into the duodenum to aid digestion by

    promoting peristalsis and absorption, preventing putrefaction,

    and emulsifying fat. During storage, a large portion of the

    water in bile is absorbed through the walls of the gallbladder,

    so that bile in the gallbladder is five to 10 times more

    concentrated than that originally secreted by the liver. When

    food enters the duodenum, the gallbladder contracts and the

    sphincter of oddi relaxes. Relaxation of this sphincter allows

    the bile to enter the intestine. This response is mediated by

    secretion of the hormone cholecystokin-pancreozymin (CCK-PZ)

    from the intestinal wall.

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    Pathophysiology:

    A.Narrative form:

    Cholesterol, a normal constituent of bile, is insoluble in

    water. Its solubility depends on bile acids and lecithin

    (phospholipids) in bile. In gallstone- prone patients, there is

    decreased bile acid synthesis and increased cholesterol

    synthesis in the live, resulting in bile supersaturated with

    cholesterol, which precipitates out of the bile to form stones.

    The cholesterol- saturated bile predisposes to the formation of

    gallstones and acts as an irritant that produces inflammatory

    changes in the gallbladder.

    Two to three times more women than men develop cholesterol

    stones and gallbladder disease; affected women are usually older

    than 40 years of age, multiparous, and obese patient. Stone

    formation is more frequent in people who use oral

    contraceptives, estrogens, or clofibrate; these medications are

    known to increase biliary cholesterol saturation. The incidence

    of stone formation increases with age as a result of increased

    hepatic secretion of cholesterol and decreased bile acid

    synthesis.

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    B.Schematic form:Predisposing Factors:

    Advanced Age

    Gender

    Ileal

    Resection/Disease

    Race

    Genetics

    Precipitating Factors:

    Obesity/ Overweight

    Pregnancy/

    Contraception

    Frequent Starvation,

    total

    parenteral nutrition

    Clofibrate Use

    Diet/

    Weight loss

    Decreased

    level of Bile

    Acids

    Increased levels

    of fat in

    The blood stream

    Synthesis of

    cholesterol

    In the liver

    Excretion of

    cholesterol

    to the bile

    Ratio of bile salts &

    lecithin with

    cholesterol is no

    longer within the

    area of solubility

    Cholesterol concentration >

    Solubility capacity of the

    bile

    No formation of mixed

    miccelles

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    Lithogenic bile/ supersaturated

    bile (creamy)

    Mucoprecipitates of organic &

    inorganic calcium salts become

    nucleation sites

    Nucleation and production of

    cholesterol monohydrate crystals

    Large cholesterol stones

    Extrusion of stones from

    gallbladder

    Impaction at cystic and bile duct

    Distention of

    billiary and

    fundus of

    gallbladder

    Forceful

    contraction

    of

    gallbladder

    Spasms of

    smooth muscle

    in the duct

    PAIN

    Bile not excreted to duodenum

    Backflow of the bile and goes to

    the circulation

    Levels of

    bilirubin/

    bile

    pigments in

    the

    circulation

    Conversion

    of bilirubin

    to

    urobilinogen

    in the

    intestines

    Excretion of

    urobinilogen

    in the stool

    Grayish

    stool

    Fat not emulsified

    No absorption

    of fat in the

    intestines

    y Nausea andVomiting

    y Fullnessy Indigestiony Vit. ADEK

    Increased

    renal

    excretion

    Dark urine

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    Preparation of the patient:

    A.Skin preparation:

    Begin at the intended sight of incision, either right subcostal,

    right paramedian, or midline, extending from the axilla to the

    pubic symphysis and down to the table on the sides.Skin isprepared with appropriate antiseptic solution (povidone iodine

    solution) at least 1/2-1 hour before surgery and just before

    surgery.

    B.Draping:4 folded towels and a laparotomy sheet, sterile sheets are used

    to cover all of the body except the operation site and adhesive

    drapes are stuck on the operation site.

    Position of patient during induction of anesthesia:

    Lateral position: patient

    begins in supine position. Rolled onto side- operative side up.

    Bottom leg flexed; top leg straight. Bottom arm on armboard, top

    arm on special arm support or pillow. Head supported in

    alignment with body.

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    Position of the patient during the surgery:

    Supine position:a position of the body:

    lying down with the face up, as opposed to the prone position,

    which is face down, sometimes with the hands behind the head or

    neck. When used in surgical procedures, it allows access to the

    peritoneal, thoracic and pericardial regions; as well as the

    head, neck and extremities. Using terms defined in the

    anatomical position, the dorsal side is down, and the ventral

    side is up.

    C.AnesthesiaSubarachnoid block or Spinal anesthesia is an

    extensive nerve block that is produced into the

    subarachnoid space at the lumbar level, usually between L4

    and L5. It produces anesthesia of the lower extremities,

    perineum, and lower abdomen. For lumbar puncture procedure,

    the patient usually lies on the side in a knee- chest

    position. Sterile technique is used as a spinal puncture is

    made and medication is injected through the needle. As soon

    as the injection has been made, the patient is positioned

    on her back. The spread of anesthetic agent and the level

    of anesthesia depend on the amount of fluid injected, the

    speed with which it is injected, the positioning of the

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    patient affecter the injection, and the specific gravity of

    the agent.

    Discussion of the Procedure:

    The incision is right subcostal. The abdominal cavity is entered

    in the usual manner. The gallbladder is grasped. The cystic

    duct, cystic artery, and common bile duct are exposed. The

    surgeon must be aware of anomalies of these structures. The

    cystic artery is clamped using two right angle clamps and

    ligated with a suture passed on a long instrument or by clips,

    as is the cystic duct. The gallbladder is mobilized by incising

    the overlying peritoneum and after local dissection is removed.

    The underlying liver bed may be reperitonealized. A drain may be

    employed exiting a stab wound and secured to the skin with a

    stitch. The wound is closed layer by layer. The skin is closed

    with interrupted stitches.

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    INSTRUMENTATION

    Retractors:

    Army navy retractor

    - Held at one to shallow or superficial incisions.Richardson retractor

    - Used to pull layers of tissue aside in deep abdominal orchest incision.

    Deaver

    - Used to retract deep abdominal or chest incisions.

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    Doyen:

    - Used by surgeons to either actively separate the edges of asurgical incision or wound, or can hold back underlying

    organs and tissues, so that body parts under the incision

    may be accessed.

    Forceps:

    Tissue forceps

    - An instrument with one or more fine teeth at the tip ofeach blade for controlling tissues during surgery,

    especially during suturing.

    Thumb forceps

    - The forceps used for grasping soft tissue; used especiallyduring suturing.

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    Scissors:

    Mayo (curved)

    - designed for cutting body tissues near the surface of the

    wound.

    - used for cutting heavy fascia and sutures.

    Mayo (straight)

    - Used to cut suture and supplies.Metzenbaum

    - Is more delicate than Mayo scissors which is used to cutdelicate tissues.

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    Clamps:

    Towel clip

    - Used to hold towels and drapes in place.Allis

    - Give surgeons the freedom to access internal organs andstructures with minimal damage to the overlying tissues.

    These forceps can grasp, hold, move or lock a tissue into a

    specific position so the surgeon can concentrate on the

    area requiring the surgical procedure. The locking and non-

    locking options give surgeons more options and flexibility.

    Right-angle or Mixter

    - provides a straight surface to cut along when dividing tissue

    that has been occluded.

    - used to clamp hard-to-reach vessels and to place sutures

    behind or around a vessel.

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    Straight clamp:

    - They may be used for occluding blood vessels, manipulating[tissues], or for assorted other purposes.

    Curvedclamp:

    - They may be used for occluding blood vessels, manipulating[tissues], or for assorted other purposes.

    Needle holder

    - Locks the needle in place, allowing the user to maneuverthe needle through various tissues.

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    Miscellaneous:

    Knife or blade holder (#3)

    - Used to cut superficial tissue.

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    Others:

    The dissection is started from gall bladder downwards.

    Anterior and posterior peritoneal leaves are stripped off

    gently. Cystic duct is gradually exposed by stripping fibrous

    bands and lymphatics. A lymph node is usually a land mark for

    cystic artery. Cystic artery is similarly exposed and

    skeletonised. It is critical that no structure is divided until

    the cystic duct and cystic artery are unequivocally identified.

    The fundus of gall bladder is then pushed in lateral and

    cephalad direction. This maneuver exposes the entire gall

    bladder, cystic duct and porta hepatis.

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