olga huk, md, frcsc curriculum vitae may 2009 c… · new york, ny hip arthroplasty ... 1985...

Olga Huk, MD, FRCSC Curriculum Vitae May 2009

IDENTIFICATION Name Olga L. Huk, M.D., FRCSC

Office Address SMBD-Jewish General Hospital, Room E-003 3755 Côte Ste-Catherine Road Montréal, QC H3T 1E2

Telephone (514) 340-8222 ext. 3605

Fax (514) 340-7595

EDUCATION Undergraduate Sept. 1977 - June 1980 McGill University, Montreal, QC Faculty of Science Honors Physiology Degree: B.Sc. Sept. 1975 - June 1977 Marianopolis College, Montreal, QC Health Sciences Degree: DEC Medical Aug. 1980 - June 1985 McGill University, Montreal, QC Faculty of Medicine Degree: M.D.C.M. Post-graduate training Research July 1985 - June 1986 University of Montreal, Montreal, QC Faculty of Medicine Masters in Clinical Science Degree: M.Sc. Clinical July 1991 - June 1992 Cornell University Medical College The Hospital for Special Surgery New York, NY Hip Arthroplasty Fellowship July 1990 - June 1991 Université de Montréal, Montreal, QC Hôtel-Dieu de Montréal Clinical Fellowship Orthopaedic Surgery

Olga Huk, MD, FRCSC Curriculum Vitae April 2009

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July 1986 - June 1990 Université de Montréal, Montreal, QC Orthopaedic Surgery Residency Programme d'Orthopédie Edouard Samson Degree: F.R.C.S.C. July 1984 - June 1985 Queen Elizabeth Hospital, Montreal, QC Mixed Internship Pedagogical Training Professorial Training Workshop. Problem Oriented Learning. Part II. Université de Montréal, Faculté de Médecine. Unité de Recherche et de Développement en Education Médicale. Laval, Québec. March 17-18, 1994. Research Methodology. Université de Montréal, Faculté de Médecine. Unité de Recherche de Développement Education Médicale. Laval, Québec. February 4, 1994. Professorial Training Workshop. Introduction: Problem Oriented Learning. Part I. Université de Montréal, Faculté de Médecine. Unité de Recherche et de Développement en Éducation Médicale. Bromont, Québec. May 18-20, 1993. Professional Certifications 1991 - 1993 New York State Licence

1990 Certified Specialist Orthopaedic Surgery (C.S.P.Q.) The College of Physicians and Surgeons of the Province of Quebec

1990 Fellowship of the Royal College of Surgeons of Canada (F.R.C.S.)

Orthopaedic Surgery

1985 - present Registered Medical Practitioner La Corporation Professionnelle des Médecins du Québec

1985 Licentiate Medical Council of Canada (L.M.C.C.)

1985 Diplomate of the National Board of Medical Examiners, USA

Professional Affiliations (Membership) The Canadian Orthopaedic Association

The Association of Orthopaedic Surgeons of Quebec

American Academy of Orthopaedic Surgeons

Canadian Orthopaedic Research Society

Société International de Chirurgie Orthopédique et de Traumatologie (SICOT)


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APPOINTMENTS University 1994 - present Assistant Professor of Surgery Department of Surgery, McGill University 1994 - present Project Director, Orthopaedic Research Laboratories Lady Davis Institute for Medical Research 1992 - 1994 Clinical Lecturer Department of Surgery, Université de Montréal Hospital 1998 - present Consulting Staff Orthopaedic Surgeon Jewish Rehabilitation Hospital 1994 - present Attending Staff Orthopaedic Surgeon Department of Orthopaedic Surgery SMBD - Jewish General Hospital 1992 - 1994 Attending Staff Orthopaedic Surgeon Division of Orthopaedic Surgery Hôpital Hôtel-Dieu de Montréal 1992 - 1994 Associate Member with Privileges in Orthopaedics Centre Hospitalier Côte-des-Neiges 1992 - 1994 Associate Member with Privileges in Orthopaedics Centre Hospitalier Ste-Jeanne d'Arc 1991 - 1992 Junior Attending Surgeon The Hospital for Special Surgery, New York, NY 1991-1992 Junior Attending Surgeon Sloan-Kettering Memorial Cancer Centre, New York, NY 1991 - 1992 Junior Attending Surgeon Department of Orthopaedic Surgery The New York Hospital-Cornell Medical Centre


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ADMINISTRATIVE RESPONSABILITIES Committees 2005-2008: Adult arthroplasty Subsection Head, Scientific COA Program Committee 2000-present: Canadian Joint Registry, Quebec Representative 2000-present : Member, Scientific Board, Société International de Chirurgie Orthopédique et de

Traumatologie (SICOT) October 2000: National Institute of Health (NIH/AAOS), Consensus Panel: “Wear 2000

Workshop”, Panel Member. Chicago, October 21-23, 2000 1997-present: Member, Committee on Epidemiology, Outcome and Clinical Guidelines,

Canadian Orthopaedic Association 1997-present: Member, Canadian Exeter User Group 1999-present: Transfusion Committee, SMBD - Jewish General Hospital 1997-2000: Member, Committee on Orthopaedic Education, Canadian Orthopaedic

Association 1996-1998: Member Strategy Group, Practice Plan in Orthopaedic Surgery 1995-1999: The Medical Council of Canada, Qualifying Examinations, Part II. Examiner 1994-1994: Member Academic Committee, Hôpital Hôtel-Dieu de Montreal 1992-1994: Member Academic Committee - Programme d'Orthopédie Edouard Samson,

Université de Montréal 1990-1992: Medical Acts Committee - Resident Member - Hôtel-Dieu de Montréal Hospital Professional and Learned Societies (a) Meeting Organizer Member, Scientific Committee. 2nd International Symposium on Advanced Biomaterials (ISAB), Montreal, June 30-July 4, 2000. Member, Scientific Committee. 1st International Symposium on Advanced Biomaterials (ISAB), Montreal, October 2-5,1997.


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Course Co-Chairperson. McGill Hip Course: From Childhood to Adult. Mont-Tremblant, Québec, March 7-9, 1997. Chairperson. Exeter Hip Symposium. Invited Guest: Professor Robin Ling, Exeter, England. Ritz Carleton Hotel, Montreal, May 6, 1996. Site Coordinator. Osteonics Satellite Hip Symposium, Institut de Recherche Clinique de Montréal. Thursday, September 14, 1995. SPECIAL HONORS, AWARDS, RECOGNITION 2007 Duncan Dowson Award, Medical Engineering Division Board of the

Institution of Mechanical Engineers Wear particles from metal-on-metal total hip replacements: Effects of

implant design and implantation time (co-author) 2005 Katryn Rolph Award, McGill University Outstanding achievement and leadership contributing to the advancement of

women in the Department of Surgery 2001 Carroll Laurin Award, Canadian Orthopaedic Foundation Immunohistochemical Localization of Apoptosis-related proteins in

Interface membranes from Aseptically Loose THA. 1999 Robert B. Salter Award, Canadian Orthopaedic Foundation Macrophage response to metal particles. 1997 CORE/ACORE Award, Canadian Orthopaedic Foundation “Macrophage response to particulate debris in vitro.” 1996 Howmedica Award Basic Science Research, Resident Research Day Programme d'Orthopédie Edouard Samson (co-author) Cytotoxicity of ceramics compared to polyethylene. 1994 CORE/ACORE Award, Canadian Orthopaedic Foundation Characterization of particulate wear debris from periprosthetic tissues of

failed ceramic-bearing THAs. 1994 Howmedica Award Basic Science Research, Resident Research Day Programme d'Orthopédie Edouard Samson (co-author) Céramique/céramique vs métal/PE: histologie comparée des PMs de

prothèses totales de hanche. 1993 Zimmer Annual Travel Award, Best Paper in Adult Reconstruction. American Orthopaedic Association


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1989 Syntex Award Basic Science Research Three-dimensional reconstructions of thelumbar spine. 1986 Howmedica Award Basic Science Research Analysis of gait patterns in unoperated Spastic diplegic children. 1981, 1982, 1983 New York Life Insurance Scholarship McGill University, Faculty of Medicine 1979, 1980 Honors, Physiology, McGill University 1978, 1979, 1980 University Scholar, McGill University 1975, 1976, 1977 Dean's List for Academic Achievement Marianopolis College 1975 Marianopolis College Entrance Award in Science INVITED LECTURES 1. OL Huk, L Sedel, A Croce, P Beaulé, H Migaud. “Face à Face”. Arthoplastie de la hanche

adulte: métal versus alumine. 10ième Congrès de l’Association des Orthopédistes de Langue Française. Montréal, QC. 12-17 septembre 2006.

2. OL Huk. What about the serum ions? COA Special Day Session on Arthroplasty. 61st

Annual Meeting of the Canadian Orthopaedic Association. Toronto, ON. June 3, 2006. 3. OL Huk. Resurfacing: Pitfalls to avoid. Instructional Breakfast Lectures. 61st Annual

Meeting of the Canadian Orthopaedic Association. Toronto, ON. June 3, 2006. 4. OL Huk. The new patient. Zimmer Techniques and Technologies for the “New Patient”.

Montreal, QC. May 14, 2005. 5. OL Huk. Metal on Metal THA. Zimmer Techniques and Technologies for the “New

Patient”. Montreal, QC. May 14, 2005. 6. OL Huk, J Antoniou, DJ Zukor. Advances in total hip arthroplasty. Colloque sur les

arthroplasties des members inférieurs. Centre Hospitalier Catherine Booth. Montreal, QC. April 8, 2005.

7. OL Huk. The use of big femoral heads. New Concepts on Surgery of the Hip. Scientific

meeting of the Quebec Orthopaedic Association. Montreal, QC. November 20, 2004.


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8. OL Huk. Metal on metal bearings. New Concepts on Surgery of the Hip. Scientific meeting of the Quebec Orthopaedic Association. Montreal, QC. November 20, 2004.

9. OL Huk, J Antoniou, DJ Zukor. Where are we with metal-metal total hips? Canadian

experience. 2nd Joint and Bone Preserving Surgery of the Hip - 2nd International Conference on Metal-Metal Hip Prostheses: Past Performance and Future Directions. Montreal, QC, June 21, 2003.

10. OL Huk, I Catelas, DJ Zukor, J Antoniou, A Petit. Metal wear products and

apoptosis/necrosis. 2nd Joint and Bone Preserving Surgery of the Hip - 2nd International Conference on Metal-Metal Hip Prostheses: Past Performance and Future Directions. Montreal, QC, June 21, 2003.

11. OL Huk. Joint repair and replacement: a new lease on life. Research Governors Society,

SMBD - Jewish General Hospital. Montreal, QC. November 6, 2002. 12. OL Huk. Why arthroplasty surgeons depend on radiology? Radiology technicians week,

SMBD - Jewish General Hospital. Montreal, QC. November 5 2002. 13. OL Huk. Advances in total hip replacement. 16th Medical Conference of the Hellenic

Medical Society of New York. Omni Hotel, Montreal, QC. June 28, 2002. 14. OL Huk. Canadian Joint Replacement Registry: an update. Symposium annuel de

l’Association d’Orthopédie du Québec. Montébello, QC. 27 septembre 2001. 15. OL Huk. Ceramic vs. polyethylene for total hip arthroplasty. Challenges in Hip and Knee

Replacement: An Advanced Course. Whistler, BC. July 12-14, 2001. 16. OL Huk. Why do alumina particles cause less periprosthetic osteolysis? Les Conférences

Scientifiques du Service d’Othopédie du C.H.U.M. - Les 30 ans du couple alumine-alumine. Montreal, QC. January 17, 2001.

17. OL Huk. What patient-related factors contribute to implant wear? NIH/AAOS Wear 2000

Workshop. Chicago, IL. October 21, 2000. 18. OL Huk. Polyethylene: an overview. Symposium on New Technologies in Hip Arthroplasty

for a New Generation of High Demand Patients. Old Museum of L’Hotel-Dieu de Montréal, QC. September 20, 2000.

19. OL Huk. Polyethylene wear issues. Orthopaedic Symposium - Whistler 2000. Faculty

Member. Whistler, BC. February 24-27, 2000. 20. OL Huk. Cross-linked N-telopeptides for evaluating particulate osteolysis. Symposium on

New Techniques in Arthroplasty. 81st Annual Alumni Meeting of Hospital for Special Surgery, Cornell Medical School, New York, NY. November 5, 1999.


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21. OL Huk. Tissue response to particulate debris. Arthroplasty Symposium, Joint Bearing Surfaces for Total Hip Arthroplasty in the New Millenium. 54th Annual Meeting of the Canadian Orthopaedic Association. St. John’s, NF. July 5, 1999.

22. OL Huk. Femoral bone defects. Total hip replacement in the year 2000. Quebec

Orthopaedic Association. Montreal, QC. May 8, 1999. 23. OL Huk. Ceramic-ceramic prostheses. Total hip replacement in the year 2000. Quebec

Orthopaedic Association. Montreal, QC. May 8, 1999. 24. OL Huk. Macrophage response to particulate debris – an in vitro model. CORE/ACORE

presentation. 53rd Annual Meeting of the Canadian Orthopaedic Association. Ottawa, ON. June 23, 1998.

25. OL Huk. Osteolysis: cause and effect. Hip and knee reconstruction: An Advanced Course.

Faculty Member, Whistler, BC. February 27-28, 1998. 26. OL Huk. The painful total hip joint replacement. Hip and knee reconstruction: An

Advanced Course. Faculty Member. Whistler, BC. February 27-28, 1998. 27. OL Huk. Total hip arthroplasty: Indications, outcome and prevention of osteolysis.

Hellenic Physician’s Association of Quebec. Montreal, QC. February 20, 1998. 28. OL Huk. Revision total hip arthroplasty. Orthopaedic Grand Rounds. Hôpital Notre Dame,

Université de Montréal, Montréal, QC. November 27, 1997. 29. OL Huk. Comparison of pseudomembranes and isolated particulate debris from ceramic-

ceramic vs metal-polyethylene total hip arthroplasty. Workshop on Sliding Surfaces. Bioceramics 10. Paris, France. October 6-9, 1997.

30. OL Huk. Asymptomatic acetabular osteolysis – When to operate? Faculty Member.

Canadian/Brazilian Combined Hip Society Meeting. Toronto, ON. July 10-11, 1997. 31. OL Huk. Particulate osteolysis. Orthopaedic Grand Rounds, Ospedale Maggiore di

Niguarda. Milano, Italy. Sponsored by Sulzer Medica. March 20, 1997. 32. OL Huk. Particulate osteolysis. Orthopaedic Grand Rounds, Felix-Platter Spital. Basle,

Switzerland. Sponsored by Sulzer Medica. March 19, 1997. 33. OL Huk. Metastatic bone lesions: Diagnosis and surgical indications. Radiation oncology

Resident Teaching Rounds. Royal Victoria Hospital. Montreal, QC. October 1996. 34. OL Huk. Update on apoptosis research in Orthopaedics. Université de Montréal,

Programme d’Orthopédie Edouard Samson Symposium for the ABC Travelling Fellows. Hôpital Sainte-Justine, Montreal, QC. May 21, 1996.


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35. OL Huk. Normal hip center and bone graft. Management of Hip Dysplasia Symposium. 51st Annual Meeting of the Canadian Orthopaedic Association, Quebec, QC. May 25-29, 1996.

36. OL Huk. Characterization of particulate wear debris from periprosthetic tissues of failed

ceramic-ceramic bearing total hip arthroplasties. 29th Annual meeting of the Canadian Orthopaedic Association. CORE/ACORE Presentation. Halifax, NS, June 3-7, 1995.

37. OL Huk. Results of total hip replacement in patients with avascular necrosis. Quebec

Orthopaedic Association Meeting. Montmagny, QC. September 23, 1995. 38. OL Huk. Retrieval of ceramic particles from in vivo tissue. Hôpital Saint-Louis de Paris.

Orthopaedic Grand Rounds. Paris, France. Tuesday, October 18, 1994. 39. OL Huk. Hip arthrography. Réunion de l'Association d'Orthopédie du Québec. Mont-

Tremblant, QC. May 26, 1994. 40. OL Huk. Current topics in total hip replacement. Polyethylene wear of non-articular

surfaces of modular acetabular components. The Alumni Association of the Hospital for Special Surgery. New York, NY. November 5-6, 1992.

41. OL Huk. Revision total hip arthroplasty. Surgical Nursing Grand Rounds. SMBD-Jewish

General Hospital. Montreal, QC. May 19, 1997. RESEARCH External Personal Support 1982 Grant for Summer Research Student, McGillUniversity Effect of Panting Frequency on the Plethysmographic Determination of Thoracic Gas

Volume in Chronic Obstructive Lung Disease. Meakins-Christie Laboratory Research Grants 2005-2006 Canadian Orthopaedic Foundation. Serum metal ion levels in patients with metal-on-metal prostheses Co-applicant Amount: $10,000 2002-2006 Fonds pour les Chercheurs et l’Aide à la Recherche Centre International de Biocapteurs et Biochips Principal Applicant: Maryam Tabrizian Co-applicant Amount: $300,000/year ($12,000/year for our laboratory)


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2001-2002 Canadian Orthopaedic Foundation Immunohistochemical localization of apoptosis-related proteins in interface

membranes from aseptically loose THA. Principal Applicant Amount : $10,000 1999-2003 Canada Foundation for Innovation. Laboratoire d’Innovation et d’Analyse de Bioperformance de Dispositifs Médicaux.

Infrastructure Grant for GRBB. Principal Applicant:L’HocineYahia Specifically for a flow cytometer (100,000$) 1996-1999 Natural Science & Engineering Research Council of Canada. Caractérisation des tissus biologiques, modélisation des articulation et conception des

appareils médicaux. Collaborator Amount : $96,050/year 1998 Canadian Orthopaedic Foundation. Cross-link N-telopeptides as markers for evaluating particulate osteolysis. Co-applicant Amount: $10,000 1996-1998 Fonds FCAR Caractérisation des tissus biologiques, modélisation des articulations et conception

des appareils médicaux. Collaborator Amount: $64,000/year 1997 Canadian Orthopaedic Foundation. Cross-linked N-telopeptides as markers for evaluating particulate osteolysis. Co-Applicant Amount : $10,000 1997 Ministère des Affaires Etrangères et du Commerce International-

Gouvernement du Canada. Travel grant given to members of GRBB Co-applicant Amount: $9,000$ 1996 Direction des Études Supérieurs et de la Recherche. Groupe de recherche en biomécanique etbiomatériaux Co-applicant Amount: $35,000 1996 Arthritis Society. Mechanisms leading to periprosthetic osteolysis. Principal Applicant (Granted but not funded)


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1995 Canadian Orthopaedic Foundation. Culture de macrophages en présence de débris d'usure de prothèses totales de hanche

en céramique-céramique et métal-polyéthylène. Principal Applicant Amount : $10,000 1993 Fondation de Recherche et d'Éducation en Orthopédie.

Caractérisation des particules de débris provenant des tissus péri-prothétiques de descellement aseptique des THAs.

Principal Applicant Amount: $3,410 1992 Fondation de Recherche et d'Education en Orthopédie. Fixation stability of ankle arthrodeses: a biomedical evaluation Principal Applicant Amount : $1,500 1991 Orthopaedic Research and Education Foundation. Release and clearance of metal debris from loose and well-fixed total hip prostheses. Co-applicant Amount: $5,000 Article in Peer Reviewed Journals 1. S Bergeron, KJ Kardash, OL Huk, DJ Zukor, J Antoniou. The long-term functional outcome

of femoral versus obturator nerve block following total knee replacement. Clin Orthop Relat Res. 467: 1458-1462, 2009.

2. S Bergeron, KJ Kardash, OL Huk, DJ Zukor, J Antoniou. The long-term functional outcome

after a single perioperative dose of dexamethasone in total hip arthroplasty. Clin Orthop Relat Res. 467: 1463-1467, 2009.

3. VS Nikolaou, SG Bergeron, OL Huk, DJ Zukor, J Antoniou. Evaluation of persistent pain

after hip resurfacing. Bull NYU Hospital for Joint Dis. 67: 168-172, 2009. 4. C Tkaczyk, OL Huk, F Mwale, J Antoniou, DJ Zukor, A Petit, M Tabrizian. The molecular

structure of complexes formed by chromium or cobalt ions in simulated physiological fluids. Biomaterials. 30: 460-467, 2009.

5. CJ Richards, D Giannitsios, OL Huk, DJ Zukor, T Steffen, J Antoniou. Risk of

periprosthetic femoral neck fracture after hip resurfacing arthroplasty: Valgus compared with anatomic alignment. A biomechanical and clinical analysis. J Bone Joint Surg [Am]. 90-A (Suppl 3): 96-101, 2008.


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6. J Antoniou, DJ Zukor, F Mwale, W Minarik, A Petit, OL Huk. Metal ion levels in the blood of patients after hip resurfacing: A comparison between twenty-eight and thirty-six millimeter-head metal-on-metal prostheses. J Bone Joint Surg [Am]. 90-A (Suppl 3): 142-148, 2008.

7. F Mwale, HT Wang, DJ Zukor, OL Huk, A Petit, J Antoniou. Effect of a type II collagen

fragment on the expression of genes of the extracellular matrix in cells of the intervertebral disc. The Open Orthop J. 2: 1-9, 2008.

8. A Petit, F Mwale, C Tkaczyk, J Antoniou, DJ Zukor, OL Huk. Cobalt and chromium ions

induce nitration of proteins in human U937 macrophages in vitro. J Biomed Mater Res-Pat A. 79A: 599-605, 2006.

9. C Fleury, A Petit, F Mwale, J Antoniou, DJ Zukor, M Tabrizian, OL Huk. Effect of cobalt

and chromium ions on human MG-63 osteoblasts in vitro: morphology, cytotoxicity, and oxidative stress. Biomaterials. 27: 3351-3360, 2006.

10. I Catelas, P Campbell, JD Bobyn, JB Medley, OL Huk. Wear particles from metal-on-

metal total hip replacements: effects of implant design and implantation time. Proc Inst Mech Eng Part H – J Eng Med. 220: 195-208, 2006.

11. A Petit, F Mwale, DJ Zukor, J Antoniou, OL Huk. Effect of bisphosphonates on the

stimulation of macrophages by alumina ceramic particles: a comparison with ultra-high-molecular-weight polyethylene. J Mater Sci: Mater Med. 17: 667-673, 2006.

12. Y-K Gong, L Luo, A Petit, OL Huk, DJ Zukor, J Antoniou, FM Winnik, F Mwale. Adhesion

of human U937 macrophages to phosphorylcholine coated surfaces. J Biomed Mater Res – Part A. 72A: 1-9, 2005.

13. I Catelas, A Petit, H Vali, C Fragiskatos, R Meilleur, DJ Zukor, J Antoniou, OL Huk.

Quantitative analysis of apoptosis vs. necrosis induced by cobalt and chromium ions in J774 macrophages. Biomaterials. 26: 2441-2453, 2005.

14. A Petit, F Mwale, C Tkaczyk, J Antoniou, DJ Zukor, OL Huk. Induction of protein

oxidation by cobalt and chromium ions in human U937 macrophages. Biomaterials. 26: 4416-4422, 2005.

15. Li Luo, A Petit, J Antoniou, DJ Zukor, OL Huk, RCW Liu, FM Winnik, F Mwale. Effect of

cobalt and chromium ions on MMP-1, TIMP-1, and TNF-α gene expression in human U937 macrophages: a role for tyrosine kinase. Biomaterials. 26: 5587-5593, 2005.

16. P Martineau, KB Filion, OL Huk, DJ Zukor, L Pilote, MJ Eisenberg, J Antoniou. Primary

hip arthroplasty costs are greater in low-volume than in high-volume Canadian hospitals. Clin Orthop Rel Res. 437: 152-156, 2005.


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17. A Petit, F Mwale, DJ Zukor, I Catelas, J Antoniou, OL Huk. Effect of cobalt and chromium ions on bcl-2, bax, caspase-3, and caspase-8 expression in human macrophages in vitro. Biomaterials. 25: 2013-2018, 2004.

18. TP Schmalzried, OL Huk. Patient factors and wear in total hip arthroplasty. Clin Orthop

Rel Res. 418: 94-97, 2004. 19. I Catelas, P Campbell, JD Bobyn, JB Medley, OL Huk. Comparison of in vitro with in vivo

characteristics of metal particles from metal-metal hip implants. J Biomed Mater Res Part B - Appl Biomater. 70B: 167-178, 2004.

20. J Antoniou, PA Martineau, KB Filion, S Haider, DJ Zukor, OL Huk, L Pilote, MJ

Eisenberg. In-hospital cost of total hip arthroplasty in Canada and the United States. J Bone Joint Surg [Am]. 86A: 2435-2439, 2004.

21. OL Huk, I Catelas, F Mwale, J Antoniou, DJ Zukor, A Petit. Induction of apoptosis and

necrosis by metal ions in vitro. J Arthroplasty. 19 (suppl. 3): 84-87, 2004. 22. N Ma, A Petit, OL Huk, L’H Yahia, M Tabrizian. Safety issue of re-sterilization of

polyurethane electrophysiology catheters: a cytotoxicity study. J Biomat Sci - Polymer Ed. 14: 213-226, 2003.

23. I Catelas, JD Bobyn, JB Medley, JJ Krygier, DJ Zukor, OL Huk. Size, shape, and

composition of wear particles from metal-metal hip simulator testing: effects of alloy and number of loading cycles. J Biomed Mater Res, Part A. 67A: 312-327, 2003.

24. A Petit, DJ Zukor, J Antoniou, OL Huk. Effect of pamidronate on the stimulation of

macrophage TNF-α release by ultra-high-molecular-weight polyethylene particles: a role for apoptosis. J Orthop Res. 21: 81-87, 2003.

25. I Catelas, A Petit, DJ Zukor, J Antoniou, OL Huk. TNF-α secretion and macrophage

mortality induced by cobalt and chromium ions in vitro – Qualitative analysis of apoptosis. Biomaterials. 24: 383-391, 2003.

26. A Petit, DJ Zukor, I Catelas, J Antoniou, OL Huk. Differential apoptotic response of J774

macrophages to alumina ceramic and ultra-high-molecular-weight polyethylene particles. J Orthop Res. 20: 9-15, 2002.

27. A Petit, DJ Zukor, J Antoniou, OL Huk. Expression of caspase-8 and caspase-3 proteins in

interface membranes from aseptically loose total hip arthroplasties. J Mater Sci - Mater Med. 13: 1001-1005, 2002.

28. N Ma, M Tabrizian, A Petit, OL Huk, L’H Yahia. Cytotoxic reaction and TNF-α response

of macrophages to polyurethane particles. J Biomater Sci.-Polymer Ed. 13: 257-272, 2002.


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29. I Catelas, JD Bobyn, JB Medley, J Krygier, DJ Zukor, A Petit, OL Huk. Effect of digestion protocols on metal particles from metal-on-metal hip simulator. Part I. Analysis of particle size and shape. J Biomed Mater Res. 55: 320-329, 2001.

30. I Catelas, JD Bobyn, JB Medley, DJ Zukor, A Petit, OL Huk. Effect of digestion protocols

on metal particles from metal-on-metal hip simulator. Part II. Analysis of ion release and particle composition. J Biomed Mater Res. 55: 330-337, 2001.

31. OL Huk, A Petit, W Ralston, A Lisbona, DJ Zukor. Apoptosis in interface membranes from

aseptically loose total hip arthroplasty. J Mater Sci: Mater in Med. 12: 653-658, 2001. 32. I Catelas, A Petit, DJ Zukor, OL Huk. Cytotoxic and apoptotic effects of metal ions on J774

macrophages - Implication of caspase-3 in the apoptotic pathway. J Mater Sci - Mater Med. 12: 949-953, 2001.

33. J Antoniou, OL Huk, DJ Zukor, M Alini. Collagen crosslinked N-telopeptides as markers

for evaluating particulate osteolysis: a preliminary study. J Orthop Res. 18: 64-67, 2000. 34. I Catelas, A Petit, DJ Zukor, R Marchand, L’H Yahia, OL Huk. Cytotoxicity and

macrophage cytokine release induced by ceramic and polyethylene particles in vitro. J Bone Joint Surg [Br] 81B: 516-521, 1999.

35. I Catelas, A Petit, DJ Zukor, R Marchand, L’H Yahia, OL Huk. Induction of macrophage

apoptosis by ceramic and polyethylene particles in vitro. Biomaterials. 20: 625-630, 1999. 36. I Catelas, A Petit, R Marchand, L’H Yahia, OL Huk. Flow cytometric analysis of

macrophage response to ceramic and polyethylene particles: effect of size, concentration, and composition. J Biomed Mater Res. 41: 600-607, 1998.

37. S Lerouge, OL Huk, L’H Yahia, J Witvoet, L Sedel. Ceramic-Ceramic vs. Metal-

polyethylene Hips: Comparison of periprosthetic tissue. J Bone Joint Surg [Br]. 79B: 135-139, 1997.

38. S Lerouge, OL Huk, L’H Yahia, L Sedel. Characterization of in vivo wear debris from

ceramic-ceramic total hip arthroplasties. J Biomed Mater Res. 32: 627-633, 1996. 39. SG Kantor, MH Huo, OL Huk, EA Salvati. Cemented total hip arthroplasty in patients with

osteonecrosis. A 6-year minimum follow-up study of second generation cement techniques. J Arthroplasty. 11: 267-271, 1996.

40. EA Salvati, JR Lieberman, OL Huk, BG Evans. Complications of femoral and acetabular

modularity. Clin Orthop Rel Res. 319: 85-93, 1995. 41. JA Rodriguez, OL Huk, PM Pellicci, PD Wilson. Autogenous bone grafts from the femoral

head for the treatment of acetabular deficiency in primary total hip arthroplasty with cement. J Bone Joint Surg [Am]. 77A: 1227-1233, 1995.


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42. OL Huk, M Bansal, F Betts, CM Rimnac, EA Salvati. Polyethylene and metal debris generated by non-articulating surfaces of modular acetabular components. J Bone Joint Surg (Br). 76-B: 568-574, 1994.

43. BG Evans, EA Salvati, MH Huo, OL Huk. The rationale for cemented total hip

arthroplasty. Orthop Clinics North America. 24: 599-610, 1993. 44. S Pilette, OL Huk, L’H Yahia, JV Fowles. Evaluation biomécanique comparative de la

stabilité immédiate de trois fixateurs dans l'arthrodèse de la cheville. Ann Chirurg. 47: 905-911, 1993.

45. OL Huk, JV Fowles, MN Newman. Recurrent massive subperiosteal hemorrhage in a

patient with neurofibromatosis: A case report. Can J Surg. 34: 259-262, 1991. 46. SA Shore, OL Huk, S Mannix, JG Martin. Effect of panting frequency on the

plethysmographic determination of thoracic gas volume in chronic obstructive lung disease. Am Rev Resp Diseas. 128: 54-59, 1983.

Book Chapters and Books 1. TP Schmalzried, OL Huk. What Patient-Related Factors Contribute to Implant Wear? In:

Implant Wear in Total Joint Replacement 2001. American Academy of Orthopaedic Surgeons, Rosemont, IL. Goodman and Wright, Eds. pp. 13-19, 2001.

2. B Evans, OL Huk. Editorial Overview. Hip Section. Current Opinion in Orthopaedics.

Current Science, Philadelphi., 6 : 1, 1995. 3. B Evans, OL Huk, PM Pellici. Editorial Overview. Hip Section. Current Opinion in

Orthopaedics. Current Science, Philadelphia. 5: 1-2, 1994. 4. EA Salvati, OL Huk,. Editorial Overview. Hip Section. Current Opinion in Orthopaedics.

Current Science, Philadelphia. 4: 1-2, 1993. 5. EA Salvati, OL Huk. Editorial Overview. Hip Section. Current Opinion in Orthopaedics.

Current Science, Philadelphia. 3: 425-426, 1992. Published abstracts 1. A Petit, F Mwale, J Antoniou, DJ Zukor, OL Huk. Induction de l’oxydation des protéines

par les produits de l’usure des prothèses totales de la hanche? Médecine/Sciences. 19 (Suppl 2); 28, 2003.

2. A Petit, I Catelas, DJ Zukor, F Mwale, J Antoniou, OL Huk. Inhibition de l’expression de

Bcl-2 par les ions cobalt et chrome. Médecine/Sciences. 18 (Suppl 2); 23, 2002.


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3. OL Huk, I Catelas, DJ Zukor, F Mwale, J Antoniou, A Petit. Effet des ions cobalt et chrome sur l’activité des caspases. Médecine/Sciences. 18 (Suppl 2); 24, 2002.

4. A Petit, DJ Zukor, F Mwale, J Antoniou, OL Huk. Bisphosphonates et prothèses de la

hanche: que disent les études in vitro? Médecine/Sciences. 17 (Suppl 2); 52, 2001. 5. A Petit, DJ Zukor, OL Huk. La sécrétion de TNF-α induite par les particules de

polyéthylène de très haut poids moléculaire (UHMWPE) est inhibée par le pamidronate: implication de l’apoptose. Médecine/Sciences. 16 (suppl. 2): 30, 2000.

6. OL Huk, W Ralston, DJ Zukor, A Petit. Identification of apoptosis-related proteins in

pseudomembranes of aseptically loose total hip arthroplasty. J Bone Joint Surg [Br]. 81-B (suppl. I): 99, 1999.

7. I Catelas, A Petit, DJ Zukor, OL Huk. Le Test de l’Annexine V échoue à démontrer la

présence d’apoptose dans les macrophages J774A.1 de souris. Médecine/Sciences (suppl. 2): 14, 1999.

8. A Petit, DJ Zukor, OL Huk. Réponse des macrophages J774 aux particules d’alumine

(Al2O3) et de polyéthylène de très haut poids moléculaire (UHMWPE). Médicine/Sciences. 15 (suppl. 2): 36, 1999.

9. A Petit, DJ Zukor, OL Huk. Implication d’un processus dépendant de la caspase-3 et

indépendant de la p53 dans l’induction de l’apoptose dans les pseudomembranes de prothèses de hanches ayant échoué. Médecine/Science. 14 (suppl. 2):39, 1998.

10. A Petit, W Ralston, DJ Zukor, OL Huk. Présence d’apoptose dans les pseudomembranes

de prothèses de hanches ayant échoué. Médecine/Science. 13 (suppl. 2):19, 1997. 11. OL Huk, M Bansal, JR Lieberman, F Betts, MH Huo, EA Salvati. Generation of

polyethylene and metal debris from cementless modular acetabular components in total hip arthroplasty. J Bone Joint Surg - Orthopaedic Transactions. 17: 791-792, 1993-1994.

12. JA Rodriguez, OL Huk, PM Pellicci, PD Wilson. Long-term results of autogenous femoral

head bone grafting for acetabular deficiency in total hip arthroplasty. J Bone Joint Surg [Br] - Orthopaedic Proceedings. 76-B (suppl. I): 25, 1994.

13. OL Huk, J Braun, JR Lieberman, B Ghelman, EA Salvati. Comparison of acetabular and

femoral components alignment in dislocators vs on dislocators with total hip arthroplasties. J Bone Joint Surg (Br) - Orthopaedic Proceedings. 76-B (suppl. I): 28, 1994.

14. S Lerouge, OL Huk, L’H Yahia, L Sedel. Céramique/céramique vs. métal/polyéthylène:

histologie et biochimie comparés de pseudomembranes de prothèses totales de hanche aseptiquement descellées. Annales de Chirurgie, 48 :800, 1994.


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15. SG Kantor, OL Huk, M Huo, EA Salvati. Total hip replacement in patients with osteonecrosis: A six year minimum follow-up. J Bone Joint Surg - Orthopaedic Transactions. 16: 707-708, 1992-1993.

16. S Pilette, OL Huk, N Hamel, L’H Yahia, JV Fowles. Fixation stability of ankle

arthrodesis: A biomechanical evaluation. J Bone Joint Surg [Br] - Orthopaedic Proceedings. 75B (suppl. III): 234, 1993.

17. JA Rodriguez, OL Huk, PM Pellici, PD Wilson. Long-term results of autogenous femoral

head bone grafting for acetabular deficiency in total hip arthroplasty. J Bone Joint Surg - Orthopaedic Transactions. 17: 151, 1993.

18. N Hamel, S Pilette, L’H Yahia, OL Huk, JV Fowles. Étude biomécanique de trois fixateurs

dans l'arthrodèse de la cheville. Annales de Chirurgie, 46: 866, 1992. Presentations at Scientific Meetings 1. J Antoniou, A Petit, F Mwale, DJ Zukor , OL Huk. Metal ions in the blood of patients

with Articular Surface Replacement. 64th Annual Meeting of the Canadian Orthopaedic Association. Whistler, BC. July 3-6, 2009.

2. J Antoniou, A Petit, F Mwale, DJ Zukor, OL Huk. Surgical variables affect metal ion

levels in the blood of patients with hip surface arthroplasty. 64th Annual Meeting of the Canadian Orthopaedic Association. Whistler, BC. July 3-6, 2009.

3. V Nikolaou, A Petit, OL Huk, DJ Zukor, J Antoniou. Large head metal-on-metal yotal hip

arthroplasty versus hip resurfacing surgery in patients under 60 years of age. Is there a difference to the clinical outcome? 64th Annual Meeting of the Canadian Orthopaedic Association. Whistler, BC. July 3-6, 2009.

4. V Nikolaou, A Petit, OL Huk, DJ Zukor, J Antoniou. Metal-on-metal total hip

arthroplasty: Five to eleven years follow-up. 64th Annual Meeting of the Canadian Orthopaedic Association. Whistler, BC. July 3-6, 2009.

5. J Antoniou, F Mwale, DJ Zukor , OL Huk, A Petit. Oxidative stress markers in the blood

of patients with Articular Surface Replacement. 43rd Annual Meeting of the Canadian Orthopaedic Research Society. Whistler, BC. July 3-4, 2009.

6. J Antoniou, C Tkaczyk, A Petit, F Mwale, DJ Zukor, M Tabrizian, OL Huk. Oxidative

stress markers are not elevated in blood of patients with metal-on-metal hip prosthesis. Annual Meeting of the American Academy of Orthopaedic Surgeons. Las vegas, NV. February 25-28, 2009.

7. J Antoniou, F Mwale, DJ Zukor, OL Huk, A Petit. Metal ion levels in blood of patients

with articular surface replacement. 55th Annual Meeting of the Orthopaedic Research Society. Las Vegas, NV. February 22-25, 2009.


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8. J Antoniou, A Petit, F Mwale, DJ Zukor, OL Huk. Surgical variables affect metal ion

levels in blood of patients with articular surface replacement. 55th Annual Meeting of the Orthopaedic Research Society. Las Vegas, NV. February 22-25, 2009.

9. C Tkaczyk, A Petit, F Mwale, J Antoniou, DJ Zukor, M Tabrizian, OL Huk. Antioxidant

enzymes and oxidative stress markers in the blood of patients with metal-on-metal total hip arthroplasty. 55th Annual Meeting of the Orthopaedic Research Society. Las Vegas, NV. February 22-25, 2009.

10. E Logan, OL Huk, J Antoniou, F Mwale, A Petit, M.Tabrizian. Effect of Co2+, Cr3+, Cr6+

ions on the expression of bone markers in MG-63 pre-osteoblast cells in vitro. 55th Annual Meeting of the Orthopaedic Research Society. Las Vegas, NV. February 22-25, 2009.

11. C Tkaczyk, A Petit, I Semova, F Mwale, DJ Zukor, J Antoniou, M Tabrizian, OL Huk.

Oxidative stress markers in the blood of patients with metal-on-metal total hip arthroplasty. 2nd Combined Meeting of the AOA-COA/CORS. Quebec, QC. June 4-7, 2008.

12. K Debiparshad, OL Huk, DJ Zukor, A Petit, F Mwale, J Antoniou. Metal-on-metal total

hip arthroplasty: four to ten - year results. 2nd Combined Meeting of the AOA-COA/CORS. Quebec, QC. June 4-7, 2008.

13. F Mwale, G Marguier, A Petit, HT Wang, OL Huk, DJ Zukor, J Antoniou.

Characterization of intervertebral disc cells behavior in a mouse subcutaneous model. 41st Annual Meeting of the Canadian Orthopaedic Research Society. Halifax, NS. June 1-3, 2007.

14. F Mwale, J Antoniou, G Marguier, OL Huk, DJ Zukor, LE Chalifour. Effect of the

anticancer drug Doxorubicin and the protective agents Amifostine and Dexrazoxane on bone mass in male rats. 41st Annual Meeting of the Canadian Orthopaedic Research Society. Halifax, NS. June 1-3, 2007.

15. J Antoniou, A Petit, F Mwale, DJ Zukor, OL Huk. Metal ion and oxidative stress marker

levels in blood of patients after hip resurfacing: a comparison with 28 mm- and 36 mm-head metal-on-metal hip prostheses. 62nd Annual Meeting of the Canadian Orthopaedic Association. Halifax, NS. June 1-3, 2007.

16. CJ Richards, D Giannitsios, P Naverre, OL Huk, DJ Zukor, T Steffen, J Antoniou. Risk

factors for periprosthetic femoral neck fracture in hip resurfacing: A biomechanical analysis. 62nd Annual Meeting of the Canadian Orthopaedic Association. Halifax, NS. June 1-3, 2007.

17. S Sharma, J Antoniou, DJ Zukor, L Rosen, OL Huk. Cemented vs. Hybrid PS TKA. A

comparison of clinical and radiographic results. 62nd Annual Meeting of the Canadian Orthopaedic Association. Halifax, NS. June 1-3, 2007.


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18. J Antoniou, A Petit, F Mwale, DJ Zukor, OL Huk. Metal ion levels in blood of patients after hip resurfacing: a comparison with 28 mm- and 36mm-head metal-on-metal hip prostheses. 53rd Annual Meeting of the Orthopaedic Research Society. San Diego, CA. February 11-14, 2007.

19. Mwale, G Marguier, J Antoniou, OL Huk, DJ Zukor, LE Chalifour. The bone quality of

doxorubicin-treated male rats is less severely affected by amifostine and dexrazoxane treatments than female rats. 53rd Annual Meeting of the Orthopaedic Research Society. San Diego, CA. February 11-14, 2007.

20. J Antoniou, A Petit, F Mwale, DJ Zukor, OL Huk. Concentration of metal ions in blood of

patients with metal-on-metal hip bearings. Annual Meeting of the American Academy of Orthopaedic Surgeons. San Diego, CA. February 14-18, 2007.

21. C Tkaczyk, A Petit, F Mwale, J Antoniou, DJ Zukor, OL Huk, M Tabrizian. Formation of

chromium nanostructures in vitro: effect of cell culture media composition. 20th European Conference on Biomaterials. Nantes, France. September 27 – October 1, 2006.

22. J Antoniou, A Petit, F Mwale, DJ Zukor, OL Huk. Metal ion concentrations in blood of

patients with articular surface replacements: a comparison with metal-on-metal hip prostheses. Bioengineering for the Restoration of Joint Function Workshop. Vancouver, BC. June 8-9, 2006.

23. CJ Richards, D Giannitsios, P Naverre, OL Huk, DJ Zukor, T Steffen, J Antoniou. Hip

resurfacing – Valgus vs. neutral alignment. A biomechanical and clinical analysis of periprosthetic femoral neck fractures. 61st Annual Meeting of the Canadian Orthopaedic Association. Toronto, ON. June 2-4, 2006.

24. J Antoniou, A Petit, DJ Zukor, OL Huk. Concentration of metal ions in blood of patients

with metal-on-metal hip bearings. 61st Annual Meeting of the Canadian Orthopaedic Association. Toronto, ON. June 2-4, 2006.

25. C Tkaczyk, A Petit, F Mwale, J Antoniou, DJ Zukor, OL Huk, M Tabrizian. Albumin and

transferrin bind to chromium ions in vitro. 40th Annual Meeting of the Canadian Orthopaedic Research Society. Toronto, ON. June 2, 2006.

26. F Mwale, G Marguier, HT Wang, A Petit, OL Huk, DJ Zukor, J Antoniou. Neo-

intervertebral disc formation by subcutaneous injection of bovine disc cells in mice. 40th Annual Meeting of the Canadian Orthopaedic Research Society. Toronto, ON. June 2, 2006.

27. F Mwale, HT Wang, G Marguier, A Petit, DJ Zukor, OL Huk, J Antoniou. Effect of a type

II collagen fragment on cells of the intervertebral disc. 40th Annual Meeting of the Canadian Orthopaedic Research Society. Toronto, ON. June 2, 2006.


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28. F Mwale, G Marguier, J Antoniou, OL Huk, DJ Zukor, L Chalifour. Effect of amifostine and dexrazoxane on bone mass of doxorubicin treated male rats. 40th Annual Meeting of the Canadian Orthopaedic Research Society. Toronto, ON. June 2, 2006.

29. F Mwale, G Marguier, HT Wang, A Petit, OL Huk, DJ Zukor, J Antoniou. Cells from the

intervertebral disc maintain their phenotypes in a mouse subcutaneous injection model. 12th Annual Canadian Connective Tissue Conference. Ottawa, ON. May 25-26, 2006.

30. F Mwale, HT Wang, G Marguier, DJ Zukor, OL Huk, A Petit, J Antoniou. Effect of a type

II collagen fragment on cells of the intervertebral disc: gene expression of proteinases, collagen, and aggrecan. 12th Annual Canadian Connective Tissue Conference. Ottawa, ON. May 25-26, 2006.

31. F Mwale, G Marguier, J Antoniou, OL Huk, DJ Zukor, LE Chalifour. Effect of drugs used

for treatment of child henmatologic cancers on bone mass of male rats. 12th Annual Canadian Connective Tissue Conference. Ottawa, ON. May 25-26, 2006.

32. J Antoniou, A Petit, F Mwale, DJ Zukor, OL Huk. Metal ion concentrations in blood of

patients with articular surface replacements: a comparison with metal-on-metal hip prostheses. 52nd Annual Meeting of the Orthopaedic Research Society. Chicago, IL. March 19-22, 2006.

33. OL Huk, A Petit, F Mwale, DJ Zukor, J Antoniou. Serum levels of oxidative stress

markers in patients with articular surface replacements and metal-on-metal hip prostheses. 52nd Annual Meeting of the Orthopaedic Research Society. Chicago, IL. March 19-22, 2006.

34. C Tkaczyk A Petit, F Mwale, J Antoniou, DJ Zukor, OL Huk, M Tabrizian. Formation of

chromium nanostructures in vitro: effect of cell culture media composition. 52nd Annual Meeting of the Orthopaedic Research Society. Chicago, IL. March 19-22, 2006.

35. C Tkaczyk, A Petit, J Antoniou, DJ Zukor, M Tabrizian, OL Huk. Interaction of human

proteins with chromium nanostructures. Workshop on Chromium and Human Health. Maine Center for Toxicology and Environmental Health, University of Southern Maine. Portland, ME. August 17 - 19, 2005.

36. C Tkaczyk, A Petit, F Mwale, J Antoniou, DJ Zukor, M Tabrizian, OL Huk. Interaction of

chromium ions with human serum proteins. 52nd Annual Meeting of the Orthopaedic Research Society. Chicago, IL. March 19-22, 2006.

37. F Mwale, KL Ayuen, I Ciobanu, CN Demers, A Petit, OL Huk, DJ Zukor, J Antoniou.

Mesenchymal stem cells response to cobalt and chromium ions. 39th Annual Meeting of the Canadian Orthopaedic Research Society. Montreal, QC. June 3, 2005.

38. C Tkaczyk, A Petit, F Mwale, DJ Zukor, J Antoniou, M Tabrizian, OL Huk. Induction of

heme oxygenase-1 protein expression by cobalt ions in human U937 macrophages. 39th


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Annual Meeting of the Canadian Orthopaedic Research Society. Montreal, QC. June 3, 2005.

39. C Fleury, A Petit, F Mwale, DJ Zukor, J Antoniou, M Tabrizian, OL Huk. Cytotoxicity of

cobalt and chromium ions in human MG-63 osteoblasts in vitro. 39th Annual Meeting of the Canadian Orthopaedic Research Society. Montreal, QC. June 3, 2005.

40. F Mwale, L Luo, DJ Zukor, OL Huk, J Antoniou, FM Winnik, A Petit. Tyrosine kinases

regulate activation of matrix metalloproteinase-1 expression in cobalt and chromium ions-stimulated human U937 macrophages. 39th Annual Meeting of the Canadian Orthopaedic Research Society. Montreal, QC. June 3, 2005.

41. F Moola, OL Huk, DJ Zukor, J Antoniou. Acetabular revision: Outcomes and

complications of reconstruction rings. 60th Annual Meeting of the Canadian Orthopaedic Association. Montreal, QC. June 3-5, 2005.

42. L Luo, CN Demers, KL Ayuen, OL Huk, DJ Zukor, J Antoniou, A Petit, F Mwale. Effect of

cobalt and chromium ions on human mesenchymal stem cells. 11th Canadian Connective Tissue Conference. Montreal, QC. May 26-28, 2005.

43. L Luo, A Petit, J Antoniou, DJ Zukor, OL Huk, RCW Liu, FM Winnik, F Mwale. Effect of

cobalt and chromium ions on MMP-1, TIMP-1, and TNF-α gene expression in human U937 macrophages: a role for tyrosine kinases. 11th Canadian Connective Tissue Conference. Montreal, QC. May 26-28, 2005.

44. L Luo, CN Demers, KL Ayuen, OL Huk, DJ Zukor, J Antoniou, A Petit, F Mwale. Effect of

cobalt and chromium ions on human mesenchymal stem cells. 11th Canadian Connective Tissue Conference. Montreal, QC. May 26-28, 2005.

45. C Fleury, A Petit, F Mwale, J Antoniou, DJ Zukor, M Tabrizian, OL Huk. Cobalt and

chromium ions induce an oxidative stress in MG-63 osteoblasts in vitro. 24th Annual Meeting of the Canadian Biomaterials Society. Waterloo, ON. May 26-28, 2005.

46. C Tkaczyk, A Petit, F Mwale, J Antoniou, DJ Zukor, M Tabrizian, OL Huk. Effects of

cobalt and chromium ions on anti-oxidant enzymes expression in human U937 macrophages. 51st Annual Meeting of the Orthopaedic Research Society. Washington, DC. February 20-23, 2005.

47. C Fleury C, A Petit, F Mwale, J Antoniou, DJ Zukor, OL Huk, M Tabrizian. Effect of

cobalt and chromium ions on protein oxidation and cell morphology in human MG-63 osteoblasts in vitro. 51st Annual Meeting of the Orthopaedic Research Society. Washington, DC. February 20-23, 2005.

48. F Mwale, Y-K Gong, L Luo, OL Huk, J Antoniou, DJ Zukor, A Petit, FM Winnik.

Adhesion and proliferation of non-adherent human U937 macrophages to cell culture dishes coated with a phosphorylcholine-based polymer. 5th Combined Meeting of the Orthopaedic Research Societies. Banff, AB. October 10-13, 2004.


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49. A Petit, F Mwale, J Antoniou, DJ Zukor, C Tkaczyk, OL Huk. Cobalt and chromium ions

induce protein oxidative damage in human U937 macrophages. 5th Combined Meeting of the Orthopaedic Research Societies. Banff, AB. October 10-13, 2004.

50. C Tkaczyk, A Petit, F Mwale, J Antoniou, DJ Zukor, M Tabrizian, OL Huk. Heme

oxygenase-1 protein expression is stimulated by cobalt ions in human U937 macrophages. 5th Combined Meeting of the Orthopaedic Research Societies. Banff, AB. October 10-13, 2004.

51. C Fleury, A Petit, F Mwale, J Antoniou, DJ Zukor, M Tabrizian, OL Huk. Effect of cobalt

and chromium ions on osteoblasts in vitro. 5th Combined Meeting of the Orthopaedic Research Societies. Banff, AB. October 10-13, 2004.

52. C Tkaczyk, A Petit, OL Huk, H BVali M Tabrizian. Interaction of chromium ions with

proteins in cell culture media: formation of chromium phosphate nanostructures. 5th Combined Meeting of the Orthopaedic Research Societies. Banff, AB. October 10-13, 2004.

53. F Mwale, CN Demers, A Petit, OL Huk, DJ Zukor, J Antoniou. Link N stimulates

proliferation of young bovine disc cells but are impaired in their ability to increase matrix production. 5th Combined Meeting of the Orthopaedic Research Societies. Banff, AB. October 10-13, 2004.

54. CN Demers, F Mwale, A Petit, OL Huk, DJ Zukor, J Antoniou. Effect of the amino

terminal peptide of link protein on human mesenchymal stem cells. 5th Combined Meeting of the Orthopaedic Research Societies. Banff, AB. October 10-13, 2004.

55. CN Demers, F Mwale, D Stachura, R Segal, OL Huk, DJ Zukor, J Antoniou.

Characterization of mesenchymal stem cells from osteoarthritis patients. 2004 Gordon Conference on Musculoskeletal Biology & Bioengineering. Andover, NH. July 25-30, 2004.

56. CN Demers, W Douglas, V Lim, A Petit, T Steffen, OL Huk, DJ Zukor, J Antoniou, F

Mwale. Is bovine coccygeal intervertebral disc a suitable model to study human lumbar disc? 2004 Gordon Conference on Musculoskeletal Biology & Bioengineering. Andover, NH. July 25-30, 2004.

57. A Petit, F Mwale, DJ Zukor, J Antoniou, OL Huk. Induction of protein oxidation by cobalt

and chromium ions in human U937 macrophages in vitro. 38th Annual Meeting of the Canadian Orthopaedic Research Society. Calgary, AB. June 18-21, 2004.

58. A Petit, F Mwale, DJ Zukor, J Antoniou, OL Huk. Cobalt and chromium ions induce

nitration of proteins in human U937 macrophages in vitro. 38th Annual Meeting of the Canadian Orthopaedic Research Society. Calgary, AB. June 18-21, 2004.

59. A Petit, Y-K Gong, Françoise Winnik, DJ Zukor, J Antoniou, OL Huk, F Mwale.

Attachment of non-adherent human U937 macrophages to cell culture dishes coated with a


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phosphorylcholine polymer. 38th Annual Meeting of the Canadian Orthopaedic Research Society. Calgary, AB. June 18-21, 2004.

60. L Luo, A Petit, DJ Zukor, OL Huk, J Antoniou, F Mwale. Effect of cobalt and chromium

ions on the expression of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in human U937 macrophages in vitro. 38th Annual Meeting of the Canadian Orthopaedic Research Society. Calgary, AB. June 18-21, 2004.

61. J Antoniou, CN Demers, RL Segal, D Stachura, A Petit, OL Huk, DJ Zukor, F Mwale. Cell

surface marker expression of mesenchymal stem cells from osteoarthritis patients. 38th Annual Meeting of the Canadian Orthopaedic Research Society. Calgary, AB. June 18-21, 2004.

62. CN Demers, J Antoniou, A Petit, OL Huk, DJ Zukor, F Mwale. Do mesenchymal stem cells

undergo hypertrophy when in pellet cultures? 38th Annual Meeting of the Canadian Orthopaedic Research Society. Calgary, AB. June 18-21, 2004.

63. CN Demers, J Antoniou, A Petit, OL Huk, DJ Zukor, F Mwale. Value and limitations in

using the bovine coccygeal disc as a model for the human lumbar disc. 38th Annual Meeting of the Canadian Orthopaedic Research Society. Calgary, AB. June 18-21, 2004.

64. CN Demers, J Antoniou, A Petit, OL Huk, DJ Zukor, F Mwale. Link N cannot stimulate

matrix production but increases cell division of young bovine disc cells. 38th Annual Meeting of the Canadian Orthopaedic Research Society. Calgary, AB. June 18-21, 2004.

65. PA Martineau, K Filion, OL Huk, DJ Zukor, L Pilote, J Antoniou, MJ Eisenberg. Impact of

Hospital volume on cost of total hip arthroplasty in Canada. 59th Annual Meeting of the Canadian Orthopaedic Association. Calgary, AB. June 18-21, 2004.

66. CN Demers, F Mwale, D Stachura, R Segal, OL Huk, DJ Zukor, J Antoniou.

Characterization of mesenchymal stem cells from osteoarthritis patients. 10th Annual Canadian Connective Tissue Conference. Toronto, ON. May 28-30, 2004.

67. CN Demers, F Mwale, OL Huk, DJ Zukor, J Antoniou. Link N treatment of human

mesenchymal stem cells induces chondrogenesis while inhibiting hypertrophy, dedifferentiation, and matrix metalloproteinase expression. 10th Annual Canadian Connective Tissue Conference. Toronto, ON. May 28-30, 2004.

68. Y-K Gong, L Luo, A Petit, OL Huk, DJ Zukor, J Antoniou, FM Winnik, F Mwale.

Stimulation of TNF-α gene expression by cobalt and chromium ions in human U937 macrophages cultured on phosphorylcholine coated surfaces: a comparison with macrophages in suspension. 10th Annual Canadian Connective Tissue Conference. Toronto, ON. May 28-30, 2004.

69. A Petit, F Mwale, J Antoniou, DJ Zukor, OL Huk. Wear products from total hip

arthroplasty induce protein oxidation in human U937 macrophages. 50th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA. March 7-10, 2004.


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70. CN Demers, W Douglas, V Lim, A Petit, T Steffen, OL Huk, DJ Zukor, J Antoniou, F

Mwale. Is bovine coccygeal intervertebral disc a suitable model to study human lumbar disc? 50th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA. March 7-10, 2004.

71. L Luo, A Petit, DJ Zukor, OL Huk, J Antoniou, F Mwale. Induction of MMP-1 and TIMP-

1 gene expression by cobalt and chromium ions in human U937 macrophages in vitro. 4th Annual McGill Biomedical Graduate Conference. Montreal, QC. February 25, 2004.

72. L Luo, Y-K Gong, A Petit, OL Huk, FM Winnik, F Mwale. Stimulation of TNF-α and IL-6

expresssion by cobalt and chromium ions in human U937 macrophages cultured on phosphorylcholine coated surfaces: a comparison with macrophages in suspension. 4th Annual McGill Biomedical Graduate Conference. Montreal, QC. February 25, 2004.

73. OL Huk, DJ Zukor, J Antoniou, F Mwale, A Petit. Effect of cobalt and chromium ions on

caspase activity in human macrophages. 37th Annual Meeting of the Canadian Orthopaedic Research Society. Winnipeg, MB. October 3, 2003.

74. OL Huk, I Catelas, DJ Zukor, J Antoniou, F Mwale, C Tkaczyk, A Petit. Internalization of

metal particles and ions by macrophages in vitro. 37th Annual Meeting of the Canadian Orthopaedic Research Society. Winnipeg, MB. October 3, 2003.

75. DJ Zukor, OL Huk, J Antoniou. Implications of a manufacturer’s recall of acetabular

components. 58th Annual Meeting of the Canadian Orthopaedic Association. Winnipeg, MB. October 3-6, 2003.

76. F Mwale, M Iordanova, C Demers, V Thermil, J Chicoine, D Bullett, DJ Zukor, OL Huk, T

Steffen, P Roughley, J Antoniou. Biological evaluation of chitosan salts cross-linked to genepin as a cell scaffold for disc tissue engineering. 37th Annual Meeting of the Canadian Orthopaedic Research Society. Winnipeg, MB. October 3, 2003.

77. A Petit, F Mwale, J Antoniou, DJ Zukor, OL Huk. Induction de l’oxydation de protéines

par les produits de l’usure des prothèses totales de la hanche. 45ième Réunion Annuelle du Club de Recherches Cliniques du Québec. Orford, QC. 25-27 septembre 2003.

78. A Petit, F Mwale, J Antoniou, DJ Zukor, OL Huk. Induction of protein oxidation by wear

products from total hip arthroplasty. IXth Canadian Connective Tissue Conference. Montreal, QC. July 4-6, 2003.

79. F Mwale, M Iordonova, CN Demers, V Thermil, J Chicoine, A Petit, DJ Zukor, OL Huk, T

Steffen, P Roughley, J Antoniou. Biological evaluation of chitosan salts cross-linked to genepin as a cell scaffold for disc tissue engineering. IXth Canadian Connective Tissue Conference. Montreal, QC. July 4-6, 2003.


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80. I Catelas, H Vali, A Petit, DJ Zukor, J Antoniou, OL Huk. How do chromium ions interact with macrophages in vitro? 29th Annual Meeting of the Society for Biomaterials. Reno, NV. April 30 - May 3, 2003.

81. OL Huk, I Catelas, DJ Zukor, F Mwale, J Antoniou, A Petit. Effect of cobalt and chromium

ions on caspase activity and on bcl-2/bax expression in human macrophages. 49th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA. February 2-5, 2003.

82. F Mwale, CN Demers, A Petit, OL Huk, DJ Zukor, J Antoniou. Increased collagen

synthesis by human bone marrow stromal cells stimulated with transforming growth-beta 1 in serum free pellet cultures. 49th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA. February 2-5, 2003.

83. F Mwale, CN Demers, TJ Moriarty, C Autexier, A Petit, OL Huk, DJ Zukor, J Antoniou.

Effect of triiodothyronine on human and mouse marrow stromal cells. 49th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA. February 2-5, 2003.

84. I Catelas, H Vali, A Petit, DJ Zukor, J Antoniou, OL Huk. Internalization of chromium ions

by macrophages in vitro. 49th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA. February 2-5, 2003.

85. A Petit, I Catelas, DJ Zukor, F Mwale, J Antoniou, OL Huk. Inhibition de l’expression de

Bcl-2 par les ions cobalt et chrome. 44ième Réunion Annuelle du Club de Recherches Cliniques du Québec. St-Sauveur, QC. 19-21 septembre 2002.

86. OL Huk, I Catelas, DJ Zukor, F Mwale, J Antoniou, A Petit. Effet des ions cobalt et

chrome sur l’activité des caspases. 44ième Réunion Annuelle du Club de Recherches Cliniques du Québec. St-Sauveur, QC. 19-21 septembre 2002.

87. C Tkaczyk, A Petit, I Catelas, OL Huk, J Antoniou, DJ Zukor, M Tabrizian. Macrophage

reaction to metal-metal wear particles. 17th European Conference on Biomaterials. Barcelona, Spain. September 11-14, 2002.

88. I Catelas, A Petit, DJ Zukor, F Mwale, J Antoniou, OL Huk. Effect of cobalt and chromium

ions on macrophage mortality: apoptosis vs. necrosis. 57th Annual Meeting of the Canadian Orthopaedic Association. Victoria, BC. June 1-4, 2002.

89. A Petit, I Catelas, DJ Zukor, H Zukor, F Mwale, J Antoniou, OL Huk. Effect of cobalt and

chromium ions on macrophage TNF-α secretion: a kinetic study. 57th Annual Meeting of the Canadian Orthopaedic Association. Victoria, BC. June 1-4, 2002.

90. OL Huk, DJ Zukor, F Mwale, J Antoniou, A Petit, A. Inhibition of UHMWPE particle-

stimulated TNF-α by pamidronate and clodronate. 57th Annual meeting of the Canadian Orthopaedic Association. Victoria, BC. June 1-4, 2002.


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91. F Mwale, CN Demers, A Petit, J Termenoff, V Lim, J Fisher, DJ Zukor, OL Huk, AG Mikos, P Roughley, J Antoniou. Analysis of poly(propylene fumarate-co-ethylene glycol) as a scaffold for use in tissue engineering of intervertebral disc: retention of collagen and proteoglycan. 57th Annual meeting of the Canadian Orthopaedic Association. Victoria, BC. June 1-4, 2002.

92. J Antoniou, CN Demers, W Douglas, A Petit, P Roughley, OL Huk, DJ Zukor, R Poole, F

Mwale. A synthetic peptide of link protein alters biosynthesis of collagens II, IX and proteoglycan in cultured intervertebral disc cells. 57th Annual meeting of the Canadian Orthopaedic Association. Victoria, BC. June 1-4, 2002.

93. DJ Zukor, M Chang, OL Huk, J Antoniou. Modified direct lateral approach in primary THR:

comparison of three techniques. 57th Annual meeting of the Canadian Orthopaedic Association. Victoria, BC. June 1-4, 2002.

94. I Catelas, A Petit, C Fragistakos, F Mwale, J Antoniou, DJ Zukor, OL Huk. Quantitative

analysis of J774 macrophage death induced by cobalt and chromium ions: apoptosis vs. necrosis. 28th Annual Meeting of the Society for Biomaterials. Tampa, FL. April 24-27, 2002.

95. F Mwale, CN Demers, A Petit, J Termenoff, V Lim, J Fisher, DJ Zukor, OL Huk, AG Mikos,

P Roughley, J Antoniou. Analysis of poly(propylene fumarate-co-ethylene glycol) as a scaffold for use in tissue engineering of intervertebral disc: retention of collagen and proteoglycan. 28th Annual Meeting of the Society for Biomaterials. Tampa, FL. April 24-27, 2002.

96. I Catelas, P Campbell, JD Bobyn, JB Medley, HC Amstutz, DJ Zukor, OL Huk. Does a

hip simulator generate metal-metal particles the same size as in vivo? 48th Annual Meeting of the Orthopaedic Research Society. Dallas, TX. February 10-13, 2002.

97. OL Huk, DJ Zukor, J Antoniou, F Mwale, A Petit. Effect of pamidronate and clodronate on

UHMWPE particle-stimulated macrophages. 48th Annual Meeting of the Orthopaedic Research Society. Dallas, TX. February 10-13, 2002.

98. J Antoniou, C Demers, A Petit, OL Huk, DJ Zukor, R Poole, F Mwale. A synthetic peptide of

link protein stimulates synthesis of collagens II and IX, and proteoglycans in intervertebral disc cells. 48th Annual Meeting of the Orthopaedic Research Society. Dallas, TX. February 10-13, 2002.

99. A Petit, DJ Zukor, F Mwale, J Antoniou, OL Huk. Bisphosphonates et prothèses totales de la

hanche: que disent les études in vitro? 43ième Réunion Annuelle du Club de Recherches Cliniques du Québec. Mont Ste-Anne, QC. 20-22 septembre 2001.

100. I Catelas, A Petit, DJ Zukor, OL Huk. Cytotoxic and apoptotic effects of metal ions on J774

macrophages. 25th European Society for Biomaterials Meeting. London, UK. September 11-14, 2001.


- 27 -

101. I Catelas, P Campbell, JB Medley, DJ Zukor, OL Huk, JD Bobyn. Quantitative and compositional analysis of particles from metal-metal THRs. 25th European Society for Biomaterials Meeting. London, UK. September 11-14, 2001.

102. J Antoniou, A Petit, I Catelas, DJ Zukor, OL Huk. Effect of pamidronate on wear particle-

stimulated macrophages. 4th Combined ORS Meeting. Rhodes, Greece. June 1-3, 2001. 103. I Catelas, A Petit, J Antoniou, DJ Zukor, OL Huk. Biochemical pathway of macrophage

apoptosis induced by metal ions. 4th Combined ORS Meeting. Rhodes, Greece. June 1-3, 2001. 104. A Petit, DJ Zukor, J Antoniou, OL Huk. Pamidronate modulation of particle-induced TNF-α

release. 35th Annual Meeting of the Canadian Orthopaedic Research Society. London, ON. June 1-4, 2001.

105. A Petit, I Catelas, J Antoniou, DJ Zukor, OL Huk. Implication of caspase-3 in the induction of

apoptosis by cobalt and chromium ions. 35th Annual Meeting of the Canadian Orthopaedic Research Society. London, ON. June 1-4, 2001.

106. J Antoniou, OL Huk, A Petit, DJ Zukor, F Mwale. Human bone marrow stromal cells can

differentiate into osteoblasts via a chondrocyte phenotype in pellet cultures. 35th Annual Meeting of the Canadian Orthopaedic Research Society. London, ON. June 1-4, 2001.

107. J Antoniou, C Demers, W Douglas, D Ungar, A Petit, OL Huk, DJ Zukor, R Poole, F Mwale.

A synthetic peptide of link protein stimulates biosynthesis of collagens II, IX and proteoglycan in intervertebral disc in vitro. 7th Canadian Connective Tissue Conference. Toronto, ON. May 25-26, 2001.

108. F Mwale, C Demers, A Petit, OL Huk, DJ Zukor, R Poole, J Antoniou. Chondrogenic

differentiation of human bone marrow mesenchymal stem cells by triiodothyronin. 7th Canadian Connective Tissue Conference. Toronto, ON. May 25-26, 2001.

109. A Petit, DJ Zukor, F Mwale, J Antoniou, OL Huk. Effect of pamidronate on the stimulation of

macrophages by alumina ceramic and UHMWPE particles. 7th Canadian Connective Tissue Conference. Toronto, ON. May 25-26, 2001.

110. OL Huk, DJ Zukor, J Antoniou, A Petit. Why ceramic particles cause less periprosthetic

osteolysis? 68th Annual Meeting of the American Academy or Orthopaedic Surgeons. San Francisco, CA. February 28 - March 4, 2001.

111. A Petit, DJ Zukor, OL Huk. La sécrétion de TNF-α induite par les particules de

polyéthylène de très haut poids moléculaire (UHMWPE) est inhibée par le pamidronate: implication de l’apoptose. 42ieme Réunion Annuelle du Club de Recherches Cliniques du Québec. Bromont, QC. September 28-30, 2000.

112. N Ma, M Tabrizian, OL Huk, A Petit, L’H Yahia. Cytotoxicity of pellethane and tecothane

particles. Canadian Biomaterials Society Meeting. Hamilton, ON. August 22-24, 2000.


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113. A Petit, I Catelas, DJ Zukor, OL Huk. Co2+ and Cr3+ induce J774 macrophage apoptosis in

vitro: a role for the caspase-3/PARP pathway. 2nd International Symposium on Advanced Biomaterials. Montreal, QC. June 28 - July 1, 2000.

114. N Ma, M Tabrizian, A Petit, OL Huk, L’H Yahia. Cytotoxicity evaluation of resterilized

electrophysiology cateheters. 2nd International Symposium on Advanced Biomaterials. Montreal, QC. June 28 - July 1, 2000.

115. N Ma, M Tabrizian, A Petit, OL Huk, L’H Yahia. Macrophage response to pellethane

particles. 2nd International Symposium on Advanced Biomaterials. Montreal, QC. June 28 - July 1, 2000.

116. I Catelas, DJ Zukor, A Petit, JD Bobyn, OL Huk. Co2+ and Cr3+ ions induce TNF-α

release and J774 macrophage apoptosis in vitro. 34th Annual Meeting of the Canadian Orthopaedic Research Society. Edmonton, AB. June 3-6, 2000.

117. A Petit, DJ Zukor, OL Huk. Pamidronate inhibits the macrophage TNF-α release induced

by ultra-high-molecular-weight polyethylene (UHMWPE) particles. 34th Annual Meeting of the Canadian Orthopaedic Research Society. Edmonton, AB. June 3-6, 2000.

118. I Catelas, A Petit, DJ Zukor, OL Huk. A cautionary note on the use of Annexin V for the

quantification of particle-induced apoptosis in J774 macrophages. Annual Meeting of the Society for Biomaterials. Kamuela (Big Island), Hawai. May 15-20, 2000.

119. N Ma, M Tabrizian, A Petit, OL Huk, L’H Yahia. Cytotoxicity evaluation of resterilized

catheters. Annual Meeting of the Society for Biomaterials. Kamuela (Big Island), Hawai. May 15-20, 2000.

120. N Ma, M Tabrizian, A Petit, OL Huk, L’H Yahia. Recyclage des cathéters à base de

polyuréthane: étude de cytotoxicité. 68e Congrès de l’ACFAS. Montréal, QC. 15-19 mai 2000. 121. I Catelas, JD Bobyn, H Vali, JB Medley, P Campbell, DJ Zukor, A Petit, OL Huk. Changes

in metal-metal wear particle characteristics with isolation protocols. 46th Annual Meeting of the Orthopaedic Research Society. Orlando, FL. March 12-15, 2000.

122. A Petit, DJ Zukor, OL Huk. Differential cellular macrophage response to alumina ceramic

and ultra-high-molecular-weight polyethylene particles. 46th Annual Meeting of the Orthopaedic Research Society. Orlando, FL. March 12-15, 2000.

123. I Catelas, A Petit, DJ Zukor, OL Huk. Le test de l’Annexine V échoue à démontrer la

présence d’apoptose dans les macrophages J774A.1 de souris. 41e Réunion Annuelle du Club Recherches Cliniques du Québec. Montebello, QC. October 14-16,1999.


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124. A Petit, DJ Zukor, OL Huk. Réponse des macrophages J774 aux particules d’alumine (Al2O3) et de polyéthylène de très haut poids moléculaire (UHMWPE). 41e Réunion Annuelle du Club Recherches Cliniques du Québec. Montebello, QC. October 14-16, 1999.

125. OL Huk, DJ Zukor, A Petit. TNF-α release and poly(ADP-ribose) polymerase cleavage

represent early events in particle-induced macrophage apoptosis. 33rd Annual Meeting of the Canadian Orthopaedic Research Society. St-John’s, NL. July 3-6, 1999.

126. I Catelas, JD Bobyn, H Vali, JB Medley, A Petit, DJ Zukor, OL Huk. Effects of isolation

protocols on the identification and size of metal-metal wear particles. 33rd Annual Meeting of the Canadian Orthopaedic Research Society. St-John’s, NL. July 3-6, 1999.

127. I Catelas, JD Bobyn, H Vali, JB Medley, A Petit, DJ Zukor, OL Huk. The effect of isolation

protocols on size, shape and composition of metal-metal wear particles. 19th Annual Canadian Biomaterials Society Conference, Quebec, QC. June 2-5, 1999.

128. A Petit, DJ Zukor, OL Huk. Cellular macrophage response to alumina ceramic (Al2O3)

and ultra-high-molecular-weight-polyethylene (UHMWPE) particles. 5th Canadian Connective Tissue Conference. Montreal, QC. May 28-29, 1999.

129. J Antoniou, OL Huk, DJ Zukor, D Eyre, M Alini. Collagen cross-linked N-telopeptides for

evaluating particulate osteolysis. 66th Annual Meeting of the American Academy of Orthopaedic Surgeons. Anaheim, CA. February 4-8, 1999.

130. OL Huk, DJ Zukor, A Petit. Apoptosis in pseudomembranes of aseptically loose total hip

arthroplasty: implication of a caspase-3-dependent, p53 independent pathway. 45th Annual Meeting of the Orthopaedic Research Society. Anaheim, CA. February 1-4, 1999.

131. J Antoniou, OL Huk, DJ Zukor, D Eyre, M Alini. Collagen cross-linked N-telopeptides for

evaluating particulate osteolysis. 45th Annual Meeting of the Orthopaedic Research Society. Anaheim, CA. February 1-4, 1999.

132. I Catelas, OL Huk, A Petit, DJ Zukor, JD Bobyn. Isolation and characterization of particulate

debris from cycled metal-metal bearing surfaces. Ottawa Life Sciences National Conference. Ottawa, ON. November 17-18, 1998.

133. I Catelas, A Petit, L’H Yahia, DJ Zukor, OL Huk. An in vitro model to study the

mechanisms leading to apoptosis in pseudomembranes of aseptically loose total hip arthroplasty. Ottawa Life Sciences National Conference. Ottawa, ON. November 17-18, 1998.

134. A Petit, DJ Zukor, OL Huk. Implication d’un processus dépendant de la caspase-3 et

indépendant de la p53 dans l’induction de l’apoptose dans les pseudomembranes de prothèses de hanches ayant échoué. 40e Réunion Annuelle du Club de Recherches Cliniques du Québec. Mont-Tremblant, QC. 15-17 octobre 1998.


- 30 -

135. OL Huk, W Ralston, DJ Zukor, A Petit. Identification of apoptosis-related proteins in pseudomembranes of aseptically loose total hip arthroplasty. 32nd Annual Meeting of the Canadien Orthopaedic Research Society. Ottawa, ON. June 20-24, 1998.

136. I Catelas, A Petit, DJ Zukor, R Marchand, L’H Yahia, OL Huk. Ceraminc and polyethylene

particles induce TNF-α release after their phagocytosis by mouse macrophages in vitro. Annual Meeting of the Society for Biomaterials. San Diego, CA. April 22-26, 1998.

137. I Catelas, OL Huk, A Petit, DJ Zukor, R Marchand, L’H Yahia. In vitro macrophage

apoptosis after stimulation with ceramic and polyethylene particles. 44th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA. March 16-19, 1998.

138. I Catelas, OL Huk, A Petit, DJ Zukor, R Marchand, L’H Yahia. In vitro induction of

macrophage cytokine release by ceramic and polyethylene particles. 44th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA. March 16-19, 1998.

139. A Petit, W Ralston, DJ Zukor, OL Huk. Présence d’apoptose dans les pseudomembranes de

prothèses de hanches ayant échouées. 39e Réunion Annuelle du Club de Recherches Cliniques du Québec, 16-18 octobre, 1997.

140. OL Huk, I Catelas, R Marchand, L’H Yahia. Evaluation of macrophage response to ceramic

particles by flow cytometry. 10th International Symposium on Ceramics in Medicine, Paris, France. October 5-8, 1997.

141. W Ralston, A Petit, DJ Zukor, OL Huk. Apoptosis in pseudomembrane of failed total hip

arthroplasty. 1er Symposium International de Biomatériaux Avancés (SIBA), Montréal, QC, 2-5 octobre 1997.

142. I Catelas, A Petit, R Marchand, L’H Yahia, OL Huk. In vitro induction of apoptotic

macrophage cell death by ceramic particles. 1er Symposium de Biomatériaux Avancés (SIBA), Montréal, QC, 2-5 octobre 1997.

143. I Catelas, R Marchand, L’H Yahia, OL Huk. Flow cytometry study of macrophage response to

ceramic particles. 1er Symposium International de Biomatériaux Avancés (SIBA), Montréal, QC, 2-5 octobre, 1997.

144. I Catelas, OL Huk, A Petit, R Marchand, L’H Yahia. Evaluation of macrophage response

to ceramic particles. World Congress on Medical Physics and Biomedical Engineering, Nice, France. September 14-19, 1997.

145. W Ralston, A Petit, DJ Zukor, OL Huk. Apoptosis at the pseudomembrane-bone interface of

failed hip prostheses: demonstration by the presence of DNA laddering. 31st Annual Meeting of the Canadian Orthopaedic Research Society, Hamilton, ON. May 31-June 4, 1997.

146. I Catelas, OL Huk, R Marchand, L’H Yahia. Evaluation of macrophage response to alumina

and zirconia ceramic particles. 31st Annual Meeting of the Canadian Orthopaedic Research Society, Hamilton, ON. May 31-June 4, 1997.


- 31 -

147. I Catelas, OL Huk, A Petit, R Marchand, L’H Yahia. Evaluation of macrophage response to

alumina and zirconia ceramic particles. 17th Canadian Biomaterials Society Meeting, Montreal, QC. May 15-17, 1997.

148. AE Lisbona, E Wang, DJ Zukor, OL Huk. Apoptosis at the pseudomembrane-bone interface

of aseptically loose total hip arthroplasty. 43rd Annual Meeting of the Orthopaedic Research Society. San Francisco, CA. February 9-13, 1997.

149. W Madaracz, DJ Zukor, OL Huk, TF Korner-Bitensky. Quality of life in the octogenarian

patient following THR. McGill University Division of Geriatric Medicine Research Day. Montreal, QC. April 19, 1996.

150. OL Huk, EA Lisbona, E Wang, DJ Zukor. Apoptosis at the pseudomembrane-bone interface

of aseptically loose total hip arthroplasty. 30th Annual Meeting of the Canadian Orthopaedic Research Society. Québec City, QC. May 25-29, 1996.

151. I Catelas, OL Huk, R Marchand, L’H Yahia. Cytotoxicity of ceramic and polyethylene

particles evaluated by flow cytometry. 30th Annual Meeting of the Canadian Orthopaedic Research Society. Québec City, QC. May 25-29, 1996.

152. OL Huk, S Lerouge, L’H Yahia, L Sedel. Analysis of periprosthetic membranes from failed

ceramic-ceramic total hip arthroplasties and characterization of ceramic debris. The Alumni Association of the Hospital for Special Surgery. New York, NY. November 2-3, 1995.

153. L’H Yahia, S Lerouge, L Sedel, OL Huk. In vivo wear debris and inflammatory response in

tissue around loosened ceramic-ceramic hip prostheses. European Conference on Biomaterials. Porto, Portugal. September 1995.

154. OL Huk, S Lerouge, L’H Yahia, L Sedel, JM Villette. Ceramic-ceramic vs. metal

polyethylene: A comparative analysis of retrieved interface membranes from failed total hip arthroplasties. 41st Annual Meeting of the Orthopaedic Research Society. Orlando, FL. February 13-16, 1995.

155. S Lerouge, OL Huk, L’H Yahia, L Sedel. Céramique-céramique vs métal/polyéthylène:

histologie et biochimie comparées de pseudo-membranes de prothèses totales de hanche aseptiquement descellées. Journée de la Recherche, Département de Chirurgie, Université de Montréal, Montreal, QC. November 19, 1994.

156. S Lerouge, OL Huk, L’H Yahia, L Sedel. Characterization of particulate debris from

pseudomembranes of ceramic bearing total hip arthroplasties. Third Inter-Meeting, Societé Internationale de Recherche Orthopédique et de Traumatologie (SIROT). Boston, Massachusetts. October 27-30, 1994.

157. S Lerouge, L’H Yahia, L Sedel, OL Huk. Ceramic-ceramic vs. metal/polyethylene: compared

histological analysis of pseudomembranes from loosened total hip arthroplasties. Scientific Regulatory Interface Symposium. Ritz Carlton Hotel, Montreal, QC. October 6-7, 1994.


- 32 -

158. OL Huk. Characterization of particulate wear debris from periprosthetic tissues of failed

ceramic-bearing total hip arthroplasties. 49th Annual Meeting of the Canadian Orthopaedic Association. June 14, 1994.

159. S Lerouge, OL Huk, L’H Yahia, L Sedel. Céramique/céramique vs PE: histologie comparée

des pseudomembranes de prothèses totales de hanche descellées. Journée de la Recherche, Département de Chirurgie, Université de Montréal. Montreal, QC. 10 mai 1994.

160. OL Huk, S Pilette, JV Fowles, L’H Yahia. Fixation stability of ankle arthrodesis: A

biomechanical evaluation. 61st Annual Meeting of the American Academy of Orthopaedic Surgeons. New Orleans, Louisiana. February 24 - March 1, 1994.

161. OL Huk, EA Salvati, M Bansal, C Rimnac, F Betts, JR Lieberman, H Huo. Generation of

polyethylene and metal debris from modular acetabular component in total hip arthroplasty (THA). SICOT, 19th World Congress. Seoul, Korea. August 28 - September 3, 1993.

162. S Pilette, OL Huk, L’H Yahia, N Hamel, JV Fowles. Fixation stability of ankle arthrodesis: A

biomechanical evaluation. SIROT, 6th General Meeting. Seoul, Korea. August 27-30, 1993. 163. OL Huk, M Bansal, F Betts, C Rimnac, EA Salvati. Generation of polyethylene and metal

debris from the non-articulating surface of modular acetabular components in total hip arthroplasty. The International Hip Society Meeting. Fukuoka, Japan. August 27-28, 1993.

164. S Pilette, L’H Yahia, OL Huk, JV Fowles. Fixation stability of ankle arthrodesis: A

biomechanical evaluation. International Congress of Biomechanics. Paris, France. July 1993. 165. N Hamel, S Pilette, OL Huk, L’H Yahia, JV Fowles. Fixation stability of ankle arthrodeses:

A biomechanical evaluation. 27th Annual Meeting of the Canadian Orthopaedic Research Society. Montreal, QC. May 30 – June 3, 1993.

166. MA Rodriguez, OL Huk, PM Pellicci, PD Wilson. Long-term results of autogenous femoral

head bone grafting for acetabular deficiency in total hip arthroplasty. 48th Annual Meeting of the Canadian Orthopaedic Association. Montreal, QC. May 30 - June 3, 1993.

167. OL Huk, M Bansal, CM Rimnac, F Betts, EA Salvati, JR Lieberman, MH Huo. Generation of

polyethylene and metal debris from cementless modular acetabular components in total hip arthroplasty (THA). 48th Annual Meeting of the Canadian Orthopaedic Association. Montreal, QC. .May 30 - June 3, 1993.

168. OL Huk, JT Braun, JR Lieberman, EA Salvati, B Ghelman. Comparison of acetabular and

femoral component alignment in dislocators versus nondislocators with total hip arthroplasties. 48th Annual Meeting of the Canadian Orthopaedic Association. Montreal, QC. May 30 - June 3, 1993.

169. OL Huk, M Bansal, JR Lieberman, F Betts, MH Huo, EA Salvati. Generation of polyethylene

and metal debris from cementless modular acetabular components in total hip arthroplasty.


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39th Annual Meeting of the Orthopaedic Research Society. San Francisco, CA. February 15-18, 1993.

170. OL Huk, M Bansal, CM Rimnac, F Betts, JR Lieberman, MH Huo, EA Salvati. Generation

of polyethylene and metal debris from cementless modular acetabular components in total hip arthroplasty. 60th Annual Meeting of the American Association of Orthopaedic Surgeons. San Francisco, CA. February 18-23, 1993.

171. OL Huk, JR Lieberman, PM Pellicci, TP Sculco, EA Salvati. Aspirin versus indomethacin

versus coumadin for the prevention of deep venous thrombosis and their effect on the heterotopic ossification. 60th Annual Meeting of the American Association of Orthopaedic Surgeons. San Francisco, CA. February 18-23, 1993.


head bone grafting for acetabular deficiency in total hip arthroplasty. 60th Annual Meeting of the American Association of Orthopaedic Surgeons. San Francisco, CA. February 18-23, 1993.

173. N Hamel, S Pilette, P Limoges, L’H Yahia, OL Huk, JV Fowles. Etude biomécanique de trois

fixateurs dans l'arthrodèse de la cheville. Journée de la Recherche, Département de Chirurgie, Université de Montréal. Montreal, QC. 27 novembre 1992.


head bone grafting for acetabular deficiency in total hip arthroplasty. The Alumni Association of the Hospital for Special Surgery. New York, NY. November 5-6, 1992.

175. OL Huk, JT Braun, JR Lieberman, EA Salvati, B Ghelman. Comparison of acetabular and

femoral component alignment in dislocators versus nondislocators with total hip arthroplasties. The Alumni Association of the Hospital for Special Surgery. New York, NY. November 5-6, 1992.


head bone grafting for acetabular deficiency in total hip arthroplasty. Eastern Orthopaedic Association 23rd Annual Meeting. Dorado, Puerto Rico. October 17, 1992.


head bone grafting for acetabular deficiency in total hip arthroplasty. Urban Orthopaedic Club. New York, NY. October 17, 1992.

178. SG Kantor, MH Huo, OL Huk, EA Salvati. Total hip replacement in osteonecrosis: A six-

to-ten year minimum follow-up with modern cement techniques. 59th Annual Meeting of the American Academy of Orthopaedic Surgeons. Washington, DC. February 20-25, 1992.

179. S Doty, J Lee, O Huk, EA Salvati. In vivo ultrastructure cell response to metallic particulate

debris. The Hip Society Summer Meeting. Columbia Presbyterian Medical Centre. New York, NY. September 1991.


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180. O Huk, A Jodoin, J Deguise, C Lafortune, A Desjardins. Precision of three-dimensional reconstructions of the lumbar spine. 5th General Meeting of SIROT (Société Internationale de Recherche Orthopédique et de Traumatologie). Montreal, QC. September 1990.

181. O Huk, A Jodoin, J Deguise, C Lafortune, A Desjardins. Precision of three-dimensional

reconstructions of the lumbar spine. 24th Annual Meeting of the Canadian Orthopaedic Research Society. Vancouver, BC. June 1990.

182. O Huk, A Jodoin, A Desjardins, C Lafortune, J Deguise. La précision des reconstructions

tridimensionnelles de la colonne lombaire. Journée Chirurgicale de l'Université de Montréal. Holiday Inn Crown Plaza. Montreal, QC. November 1989.

183. O Huk, C Lafortune, A Jodoin, J Deguise, A Desjardins. Précision de reconstructions

tridimensionnelles de la colonne lombaire. Journée de Recherche, Programme d'Orthopédie Edouard Samson. Hôpital Ste-Justine, Montréal, QC. May 1989.

184. O Huk, J Deguise, C Lafortune, A Jodoin, A Desjardins. Validation de méthodes de

reconstructions tridimensionnelles du rachis lombaire. McGill Resident's Research Day. Montreal, QC. .May 1989.

185. JY St-Laurent, O Huk, M Bissonnette. Lateral digital island flap for distal fingertip

amputations. Third Annual Franklin Hand Society Meeting, Franklin Hall, Philadelphia, PA. December 1987.

186. O Huk, JY St-Laurent, M Bisonnette. Le lambeau latéro-digital en ilot pour la reconstruction

des amputations distales. Journée Chirurgicale de l'Université de Montréal, Hôtel Ritz-Carlton, Montréal, QC. November 1987.

187. M Duhaime, O Huk, H Labelle, P Allard. Kinematic analysis of gait patterns in unoperated

spastic diplegic children. SIROT (Société Internationale de Chirurgie Orthopédique et de Traumatologie), XVII World Congress, Munich, Germany. August 1987.

188. O Huk, J St-Laurent, M Bisonnette. Lateral digital island flap for distal fingertip amputation.

Programme d'Orthopédie Edouard Samson Research Day, Montreal, QC. May 1987. 189. O Huk, H Labelle, M Duhaime, P Allard. Gait patterns of unoperated spastic diplegic

children. North American Congress on Biomechanics, Montreal, QC. August 1986. 190. O Huk, M Labelle, P Allard. Kinematic analysis of gait patterns in unoperated children with

spastic diplegia. 20th Annual Meeting of the Canadian Orthopaedic Research Society. Edmonton, AB. June 1986.

191. P Allard, O Huk, M Labelle, M Duhaime. Gait patterns of unoperated spastic diplegic

children. International Society for Prosthesis and Orthotics, Copenhagen, Denmark. June 1986.


- 35 -

192. O Huk, M Labelle, M Duhaime, P Allard. Kinematic analysis of gait patterns in unoperated spastic diplegic children. Journée de la Recherche, Programme d'Orthopédie Edouard Samson. Montreal, QC. May 1986.

193. O Huk, M Labelle, M Duhaime, P Allard. Analyse kinématique des patrons de marche chez

les diplégiques spastiques non-opérés. 54th Annual Meeting of the Franco-Canadian Association for the Advancement of Science. Montreal, QC. May 1986.

194. O Huk, H Labelle, M Duhaime, P Allard. Analyse kinématique des patrons de marche chez les

diplégiques spastiques non-opérés. Journée de la Recherche de l'Université de Montréal. Hôpital du Sacré-Cœur. Montreal, QC. April 1986.

195. O Huk, H Labelle, M Duhaime, P Allard. Analyse kinématique des patrons de marche chez les

diplégiques spastiques non-opérés. Meeting of the Association des Etudiants aux Grades Supérieurs de la Faculté de Médecine, Université de Montréal. Montreal, QC. February 1986.

Research Trainees Supervised Ph.D. Cathy Tkaczyk. Biomedical Engineering, McGill University. Co-director. Metal-on-metal total hip arthroplasty: macrophage response to metallic wear products. September 2003 - Present. Isabelle Catelas. Biomedical Engineering, McGill University. Co-director. Characterization of metal particles from metal-metal hip prosthesis. September 1998 - February 2002. M.Sc. Cyrille Fleury. Biomedical Engineering, McGill University. Co-director. Effect of cobalt and chromium ions on the redox state of osteoblasts in vitro. September 2003 – May 2005. Nan Ma. Génie Biomédical, École Polytechnique de Montréal, Université de Montréal. Co-director. Effet du polyuréthane sur les macrophages. May 1999 - September 2001. Whitney Ralston. Experimental Surgery, McGill University. Director. Demonstration of apoptotic cell death in pseudomembranes of failed total hip arthroplasty with implication for CPP32 protease pathway. September 1996 - May 1998. Allan Lisbona. Experimental Surgery, McGill University. Director. Apoptosis at the pseudomembrane-bone interface of aseptically loose total hip arthroplasty. September 1995 - May 1997. Isabelle Catelas. Génie Biomédical, École Polytechnique de Montréal, Université de Montréal. Co-director. Etude in vitro de la réponse des macrophages à des particules de matériaux utilisés dans les prothèses de hanches: céramique vs polyéthylène. May 1995 - June 1997.


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Sophie Lerouge. Génie Biomédical, École Polytechnique de Montréal, Université de Montréal. Co-director. Céramique-céramique vs métal-polyéthylène: caractérisation des pseudomembranes et des débris d’usure de prothèses totales de hanche descellées. September 1993 - August 1995. Stéphane Pilette. Génie Biomédical, École Polytechnique de Montréal, Université de Montréal. Co-director. Étude mécanique de l’arthrodèse de la cheville. September 1992 - May 1994. Summer Medical Students Andre-Bogdan Gorgos. Summer Student Bursary Program, McGill Faculty of Medicine. Apoptosis in osteolytic bone from failed total hip arthroplasty. June-July 1998. P Tran. McGill University Medical Student. Quality of life in the octagenerian patient following total joint replacement surgery. January 1996 - May 1996. QH Ly. Summer research bursary, Faculté de Médicine, Université de Montréal. The non-cemented total hip replacement (femoral component). June 1st - August 30, 1993. Nicolas Aubrée. Summer research bursary, Faculté de Médecine, Université de Montréal. The non-cemented total hip replacement (acetabular component). June 1st - August 30, 1993. Other Students and Residents BinNasser, Amhed. McGill Orthopaedic Resident Research Project. Reconstruction rings for total hip arthroplasty. Presented at Resident Research Day, May 2004. Pickle, Andrew. McGill Orthopaedic Resident Research Project. Validity of pre-OP scores in autologous blood donation for total joint arthroplasty: a prospective analysis. Presented at Resident Research Day, May 2003. Pickle, Andrew. McGill Orthopaedic Resident Research Project. Autologous blood donation for joint arthroplasty: a retrospective analysis. Presented at Resident Research Day, April 2002. Farhad Moola. McGill Orthopaedic Resident Research Project. Reconstruction of acetabular defects in total hip arthroplasty: A comparison of the use of reconstruction cages and jumbo cups. Presented at Resident Research Day. May 2001. Bessette Benoit. McGill Orthopaedic Resident Research Project. Total hip arthroplasty in patients less than 21 years old: A minimum ten year follow-up. Presented at Resident Research Day. May 4, 2000. Kevin Draxinger. McGill Orthopaedic Resident Research Project. Impaction allografting: The McGill experience. Presented at Resident Research Day. May 4, 2000.


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Malcom Chang. McGill Medical Student. A comparison of abductor muscle strength after tenotomy or after osteotomy in the direct lateral approach for total hip arthroplasty. September 1999 - 2000. Ronnie Borsuk. Summer student, McGill University, Med-P. Literature review of patient-related factors and prosthetic wear. July-August 2000. Ronnie Borsuk. Summer student, Marianopolis College. Expression of bcl-2 in pseudomembranes from failed total hip arthroplasty. June-July 1999. OTHER CONTRIBUTIONS Journals (Reviewer)

- Biomaterials: Oct 2003; Nov 2006; April 2008.

- Can J Surg: 1998, 2008.

- Clin Orthop Rel Res: Mar 2005.

- Eur J Pharmacol; July 2007.

- J Biomed Mater Res: Mar 2004.

- J Bone Joint Surg: 2006 (1); 2007 (6); 2008 (6); 2009 (4).

- J Clin Pathol: Apr 2005.

- J Orthop Res: 2001.

- Toxicol Letters: Apr 2004, Oct 2004.

- Acta Biomaterialia: Sept 2008.

Grants (Reviewer)

- Fonds de la Recherche en Santé du Québec (FRSQ): 1999.

- Canadian Institute of Health Research (CIHR): 2001, 2003.

- Arthritis Research Campaign, U.K.: 2004.

Articles (non peer-reviewed) 1. OL Huk. Establishing an orthopaedic research laboratory. Canadian Orthopaedic

Association Bulletin, Vol. 40: 29, 1998. 2. OL Huk DJ Zukor. Total Hip Arthroplasty in developmental dysplasia of the hip:

Considerations for acetabular reconstruction. Canadian Orthopaedic Association Bulletin, Vol. 43: 11, 1998.


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3. OL Huk, DJ Zukor. Management of Asymptomatic acetabular osteolysis. Canadian Orthopaedic Association Bulletin, Vol. 43: 15, 1998.

4. I Catelas, R Marchand, L’H Yahia, OL Huk. Evaluation of macrophage response to ceramic

particles by flow cytometry: analysis of phagocytosis and cytotoxicity. Bioceramics. 10: 579-582, 1997.

5. OL Huk. Apoptosis, necrosis and prosthetic loosening: our laboratory update. Canadian

Orthopaedic Association Bulletin, Vol. 37: 18, 1997. 6. I Catelas, OL Huk, R Marchand, L’H Yahia. Cytotoxicity of ceramics compared to

polyethylene by flow cytometry. Bioceramics. 9: 93-96, 1996.

olga huk, md, frcsc curriculum vitae may 2009 c… · new york, ny hip arthroplasty ... 1985...

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