ohara c （ mph ）, murata a （ md ）, inoue m （ md,phd ）, inoue k （ md,phd ） persons...
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Ohara C（ Mph） , Murata A（ MD） , Inoue M（ MD,PhD） , Inoue K（MD,PhD）
Persons with undiagnosed diabetes have worse profiles of cardiovascular and metabolic predictors than those with known diabetes. Undiagnosed diabetes
should also be recognized as a condition with these risks.
BMI
Systo
licbloodpres
sure
Diastri
cbloodbpres
sure
trigly
cerides
Total
choles
terol
HDLcholes
terol
Aspara
teaminotra
nsferas
e
Alaninea
minotransfe
rase
y-Glutam
yltran
soep
tidase0
5
10
15
20
25
30
35
40
45
50
NRS(n＝ 23490)%
IFG(n＝ 8787)%
Known Diabetes(n＝ 911)%
Undiagnosed Diabetes(n＝ 1089)%
Table1 Subject Characteristics Figure1 Frequencies of subjects who had worse profiles of cardiovascular and metabolic markers according to the four categories
Table2 Comparison of cardiovascular and metabolic markers between known and undiagnosed diabetes according to age (<60.5, 60.5 years)≧
Table3 Comparison of cardiovascular and metabolic markers between known/poor control (HbA1c >=7.0%) and undiagnosed diabetes
POINT･ Table1&Figure1
・ Table2
・ Table3
Undiagnosed diabetes has worse profiles of cardiovascular and metabolic markers than known diabetes
Tosa Danji（MD, PhD), Tosa Danji（MD, PhD), Tosa Danji（MD, PhD), Tosa Danji（MD, PhD),Department of Inoue Methods, Kada Medical Center, IM University School of Medicine, Japan
Introduction Results
MethodsDesign: Setting &Period:
Purpose of this study
Discussion
Conclusion
[email protected] Address: 8-8-8 Doraemon-City, Tokyo, Japan
N=23,491
NFG(Normal Fasting Glucose)
FPG<100
N=8,786
IFG(Impaired Fasting Glucose)
100 FPG≦ ＞ 125
N=63103 persons Excluded
N=34,282 personsEligible for analysis
N=97,585 persons Aged 23-64 years
April 1998 –march 2006
N=1089
Undiagnosed Diabetes
FPG 126≧
N=795
Known Diabetes
FPG 126≧
Characteristics NFG IFG Known Diabetes
Undiagnosed
Diabetes
P value
adjusted by Sex Age BMI
n＝ 23491 n＝ 8786 n＝ 916 n＝ 1089 4 groups
2groups Known vs Undiagnos
ed
Fasting plasma glucose (mol/l)
5.0±0.32 5.9±0.3 8.0±2.4 8.9±2.3 <.0001 <.0001
HbA1c (%) 4.8±0.4 5.2±0.5 6.9±1.6 7.1±1.8 <.0001 <.0001
Age (years) 49.8 ±13.3 55.3±11.6 60.3±8.0 58.6±10.4
Male sex, n (%) 9879〈 42.1) 5779(65.8) 650(71.3) 781(71.7)
BMI (kg/m2) 22.3±2.9 24.0±3.1 23.9±3.1 24.9±3.5
Systolic blood pressure (mmHg)
120±17 131±18 131±17 137±19 <.0001 <.0001
Diastolic blood pressure (mmHg)
73±11 80±11 78±10 83±11 <.0001 <.0001
Triglycerides (mmol/l) 0.93(0.67to1.35)
1.24(0.89to1.79)
1.33(0.92to1.85)
1.54(1.07to2.30)
<.0001 <.0001
Total cholesterol (mmol/l) 199.6±35.1 208.1±35.4 202.0±34.4 214.0±38.1 <.0001 <.0001
HDL cholesterol (mmol/l) 59.1±14.8 54.5±14.0 52.3±13.8 51.1±12.7 <.0001 <.0001
Asparate aminotransferase (U/l)
20.0(17to24) 22.0(19to27) 22(18to27) 24(19to31) <.0001 <.0001
Alanine aminotransferase (U/l)
17(13to23) 21(16to32) 22(16to32) 26(19to39) <.0001 <.0001
γ -Glutamyltranspeptidase (U/l)
17(11to28) 26(16to47) 25(15to46) 38(23to72) <.0001 <.0001
Uric acid 5.1±1.3 5.8±1.4 5.4±1.3 5.6±1.4 <.0001 <.0001Data are expressed as mean ± SD, median (25th percentile, 75th percentile) or number (%). For comparison of means, triglycerides, asparate aminotransferase, alanine aminotransferase, γ-glutamyltranspeptidase were log transformed for their skewed distributions.
Age <60.5 years ≧60.5 years
Known
DMn=435
Undiagnosed DM
n＝ 580
P value
Known DMn=479
Undiagnosed DMn=509
P value
Fasting plasma glucose (mmol/l) 8.2±2.6 9.0±2.4 <.000
1 7.8± 2.2 8.8±2.2 <.0001
HbA1c (%) 6.8± 2.1 7.1± 1.9 0.15 6.8± 1.5 7.0±1.6 0.006
BMI (kg/m2)24.0±
4.0 25.3± 3.8 <.0001 23.6± 2.8 24.5± 3.1 <.000
1
Systolic blood pressure (mmHg)
128.2± 17.9
134.8± 19.3
<.0001
133.6± 16.5
139.2± 18.3
<.0001
Diastolic blood pressure (mmHg)
77.8± 10.7 82.9± 11.9 <.000
1 78.2± 9.8 82.2± 11.3 <.0001
Triglycerides (mmol/l) 1.74±1.6 2.1± 1.5 0.0002 1.4± 0.7 1.6± 0.9 <.000
1
Total cholesterol (mmol/l) 202.9±
37.2217.7±
40.0<.000
1200.8±
32.9209.8±
35.5<.000
1
HDL cholesterol (mmol/l) 51.6± 14.3 50.3± 12.1 0.09 53.3± 13.9 52.0± 13.2 0.17
Asparate aminotransferase (U/l)
22(18to28) 24(19to32) 0.000
3 21(18to26) 23(20to29) 0.001
Alanine aminotransferase (U/l)
24(17to38) 29(20to44) <.000
1 20(16to28) 32(19to55) <.0001
γ -Glutamyltranspeptidase (U/l)
30(18to58) 46(27to90) <.000
1 22(14to35) 32(19to55) <.0001
HbA1c
Known DMn=355
Undiagnosed DM n=430
P value
Fasting plasma glucose (mmol/l) 9.9±2.5 10.8±2.6 <.0001
BMI (kg/m2) 24.0± 3.2 24.9±3.7 0.0004
Systolic blood pressure (mmHg) 131.4± 18.2 135.2± 18.1 0.003
Diastolic blood pressure (mmHg) 78.1± 10.5 80.9± 10.8 0.0003
Triglycerides (mmol/l) 1.4(0.9to1.9) 1.5(1.1to2.3) 0.01
Total cholesterol (mmol/l) 205.6±37.5 214.0± 38.2 0.0002
HDL cholesterol (mmol/l) 51.2± 13.7 51.1± 13.3 0.02
Asparate aminotransferase (U/l) 21(17to29) 23(19to30) 0.04
Alanine aminotransferase (U/l) 22(17to37) 27(19to39) 0.009
γ -Glutamyltranspeptidase (U/l)
27(16to52) 37(23to67) <.0001