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NUTRITIONAL FRONTIERS Holistic Truth Defeat Inflammation Naturally with Nutritional Frontiers Inflammation is a health concern that causes both acute and chronic problems What is Inflammation: The inflammatory process consists of a cascade of events in response to injury or trauma. The traumatic insult may be physical, chemical or biological. Sometimes inflammation can occur acutely, but it may also develop into a more chronic problem. The word “inflammation” comes from the Latin inflammare, meaning “to set on fire.” The cardinal signs of inflammation are rubor, redness; calor, heat (or warmth); tumor, swelling; and dolor, pain; These signs may be seen at certain times, but not necessari- ly always present or all together. Changes to the tissues, cells, and blood vessels surrounding the inflamed area are evident. In best case scenarios, the inflammatory process leads to repair & healing. It is when the inflammatory response is abnormal, exaggerated, or prolonged that problems can occur and the inflammatory mediators can cause destruction as well as healing. The Players in Inflammation White blood cells, also called leukocytes, release inflammatory mediators such as cytokines, leukotrienes, and prostaglandins. Some types of leukocytes called phago- cytes also act by ingesting foreign particles (such as bacteria) and cellular debris. Granulocytes, monocytes, and lymphocytes are other types of white blood cells that are involved in the inflammatory process. These mediators induce increased blood flow to the area and leakage of fluid in the tissues, resulting in the symptoms of inflammation. X-Flame is a supplement by Nutritional Frontiers that targets inflammation safely and effectively. Select ingredients in X-Flame have been researched and proven to reduce pain and swelling, increase mobility, and decrease the need for over-the-counter pain medication. X-Flame contains: • Kre-Celazine® 1,500 mg • DMG HCl 250 mg • Turmeric Root Extract (95% Curcuminoids) 200 mg • Boswellia serrata Extract (65% Boswellic Acid) 200 mg • Ginger Root Extract (5% Gingerols) 50 mg • Quercetin (as Quercetin Dihydrate) 75 mg • Rutin 75 mg • Luteolin (from Perilla Leaf Extract) 8 mg • Cayenne Pepper Powder 5 mg Symptoms of Inflammation Acute inflammation may be characterized by joint pain & stiffness; redness; swollen joints that are painful to the touch; loss of function; flu-like symptoms such as fever, chills, decreased appetite, and fatigue. Inflammatory substances may irritate the joint and wear down the cartilage Inflamma- tion can also affect internal organs especially in autoimmune diseases which lead to a state of chronic inflammation. Depending on the location, inflammation can cause things like high blood pressure, asthma aacks, diarrhea, etc. Cardiovascular disease is also related to inflammation. Inflammation plays a role in the development and progres- sion of coronary artery disease. When inflammation occurs in the coronary arteries, it can trigger a series of events that can lead to heart aack and stroke: plaque, rupture of the plaque, thrombus (clot) formation, embolization into the blood vessels, and ultimately heart aack or stroke. Volume 1 Issue 1 April 2015

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Page 1: NUTRITIONAL FRONTIERS Holistic Truth03a5bcb.netsolstores.com › images › holistictruth › april2015.pdf · OMEGA 3D is a blend of non-GMO natural oils from Fish that combines

NUTRITIONAL FRONTIERS Holistic Truth

Defeat Inflammation Naturallywith Nutritional Frontiers

Inflammation is a health concern that causes both acute and chronic problems

What is Inflammation:The inflammatory process consists of a cascade of events in response to injury or trauma. The traumatic insult may be physical, chemical or biological. Sometimes inflammation can occur acutely, but it may also develop into a more chronic problem.

The word “inflammation” comes from the Latin inflammare, meaning “to set on fire.”The cardinal signs of inflammation are rubor, redness; calor, heat (or warmth); tumor, swelling; and dolor, pain; These signs may be seen at certain times, but not necessari-ly always present or all together. Changes to the tissues, cells, and blood vessels surrounding the inflamed area are evident. In best case scenarios, the inflammatory process leads to repair & healing. It is when the inflammatory response is abnormal, exaggerated, or prolonged that problems can occur and the inflammatory mediators can cause destruction as well as healing.

The Players in InflammationWhite blood cells, also called leukocytes, release inflammatory mediators such as cytokines, leukotrienes, and prostaglandins. Some types of leukocytes called phago-cytes also act by ingesting foreign particles (such as bacteria) and cellular debris. Granulocytes, monocytes, and lymphocytes are other types of white blood cells that are involved in the inflammatory process. These mediators induce increased blood flow to the area and leakage of fluid in the tissues, resulting in the symptoms of inflammation.

X-Flame is a supplementby Nutritional Frontiers

that targets inflammation safely and effectively. Select ingredients in X-Flame have been researched and proven to reduce pain and swelling, increase mobility, and decrease the need forover-the-counter pain medication.

X-Flame contains:• Kre-Celazine® 1,500 mg• DMG HCl 250 mg• Turmeric Root Extract (95% Curcuminoids) 200 mg• Boswellia serrata Extract (65% Boswellic Acid) 200 mg• Ginger Root Extract (5% Gingerols) 50 mg• Quercetin (as Quercetin Dihydrate) 75 mg• Rutin 75 mg• Luteolin (from Perilla Leaf Extract) 8 mg• Cayenne Pepper Powder 5 mg

Symptoms of InflammationAcute inflammation may be characterized by joint pain & stiffness; redness; swollen joints that are painful to the touch; loss of function; flu-like symptoms such as fever, chills, decreased appetite, and fatigue. Inflammatory substances may irritate the joint and wear down the cartilage Inflamma-tion can also affect internal organs especially in autoimmune diseases which lead to a state of chronic inflammation. Depending on the location, inflammation can cause things like high blood pressure, asthma attacks, diarrhea, etc. Cardiovascular disease is also related to inflammation. Inflammation plays a role in the development and progres-sion of coronary artery disease. When inflammation occurs in the coronary arteries, it can trigger a series of events that can lead to heart attack and stroke: plaque, rupture of the plaque, thrombus (clot) formation, embolization into the blood vessels, and ultimately heart attack or stroke.

Volume 1 Issue 1 April 2015

Page 2: NUTRITIONAL FRONTIERS Holistic Truth03a5bcb.netsolstores.com › images › holistictruth › april2015.pdf · OMEGA 3D is a blend of non-GMO natural oils from Fish that combines

Conventional Medical Approach to InflammationThe allopathic approach to treating inflammation includes an array of interven-tions. Rest, exercises, physical therapy, medications, and surgery are all part of a conventional treatment plan for both acute and chronic inflammatory diseas-es. Medications prescribed may include:NSAIDs (non-steroidal anti-inflammatory drugs) like aspirin, ibuprofen, naproxen Corticosteroids (e.g. prednisone) Methotrexate, sulfasalazine, anti-malarial drugs like hydrochloroquine.The pharmaceutical drugs typically used in these cases carry risks of side effects. For example, NSAIDS have the following possible side effects: - Gastrointestinal: upper GI bleeding, ulcers, reflux - Renal: acute kidney failure (rare), decreased creatinine clearance

Corticosteroid use may cause nervousness, restlessness, trouble sleeping, increased appetite, dizziness, sodium or fluid retention, increased susceptibility to infection, increased stomach acid secretion (leading to reflux or ulcers), osteoporosis, diabetes, Cushing’s syndrome, and irregular periods among other things.

Alternatives to Alleviating InflammationNutritional Frontiers offers several options for relieving inflammation and its effects such as X-Flame, Omega 3 & 6 Fatty Acid formulations, CybZyme and BetaZyme (taken between meals), and HA Plus.

X Flame continued...What is Kre-Celazine®Kre-Celazine® contains a patented formulation that includes fatty acids and creatine. A case study and a double-blind placebo controlled trial pending publica-tion show its efficacy in reducing inflammation, pain, swelling, stiffness, etc. in various joints.

Here are a few testimoni-als from some users:- “I really like [Kre-Celazine®] and felt it worked better than any other drug I have ever used.” (Client has bilateral arthritis and swelling in knees.)- “The test product did what my over the counter pain medicine could never do. It increased my mobility to where I could actually live a normal life.” (Client suffers from shoulder pain.)- “[Kre-Celazine®] worked so well I did not notice the pain at all during the day. It only took about 3 or 4 days to kick in.” (Client com-plains of back & knee pain.)

DMG- HClDimethylglycine Hydrochloride is a supplement that modulates cytokine production, acts as an anti-oxidant as well as anti-inflam-matory agent, and can lower homocysteine levels. DMG is a methyl donor, which means it transfers a methyl group to other substances. Methylation is required in many biological processes, and methyl donors are probably benefi-cial in the aging process, cognitive function, cardiovascular function, etc. (The full health benefits of methyl donors are still being investigated but these agents are sure to prove to be useful in an array of health conditions.) DMG also enhances athletic performance by improving oxygen utilization. DMG may have some utility in cancer, where it targets melanoma, promotes apoptosis (cell death), and prevents metastasis.

Other ingredients in X-FlameBoswellia serrata- This Ayurvedic herb targets conditions like arthritis, asthma, and colitis. Boswellia does not possess the unpleasant gastric side effects exhib-ited by pharmaceutical NSAIDs. The mechanism of action by which Boswellia improves arthritis is thought to be improved blood supply to the joints and the prevention of connective tissue breakdown.

Turmeric (Curcuma longa)- This bright yellow culinary spice is an anti-oxidant and cholagogue (stimulates gall bladder function), as well as having potent anti-inflammatory actions. Turmeric inhibits the formation of the pro-inflamma-tory mediators thromboxane and prostaglandin. Additionally, it does not interfere with beneficial prostaglandin production and therefore does not harm the stomach lining. Like Boswellia, this distinguishes it from the problematic pharmaceutical NSAIDs.

Ginger root (Zingiber off.)- A tonic to the digestive system, ginger also has analgesic and anti-inflammatory actions.

Cayenne pepper- As a synergizing herb, cayenne is said to enhance the actions of other herbs. Cayenne improves circulation and may be helpful for reducing the pain of arthritis, diabetic neuropathy, postherpetic neuralgia, psoriasis, postsurgical pain, and fibromyalgia.

Quercitin, Rutin, and Luteolin (from Perilla leaf extract) are in the dietary flavonoid family. Flavonoid intake may reduce risk of cancer, neurodegenera-tive disease, and cognitive decline associated with aging. Bioflavonoids are also used for hepatitis, chronic venous insufficiency, gingivitis, and bruising. Quer-citin has been used effectively for prostatitis, asthma, allergies, upper respirato-ry infections, and more.

Page 3: NUTRITIONAL FRONTIERS Holistic Truth03a5bcb.netsolstores.com › images › holistictruth › april2015.pdf · OMEGA 3D is a blend of non-GMO natural oils from Fish that combines

HA Plus and HA Plus Liquid are excellent supple-ments to assist in joint repair and increase joint comfort. HA stands for Hyaluronic acid, which is a substance found through the body especially in cartilage, synovial fluid, skin, and the eye. It supports connective tissue structures. HA Plus also contains Glucosamine sulfate and MSM (methylsulfonylmeth-ane) which are well known to support joint health and proper joint function.

The ingredients in Inflam can help support conditions associated with pain, swelling, & inflammation such as arthritis. This formula was designed to help increase mobility and may decrease the need for over-the-counter pain medication. Inflammation is associated with health conditions such as arthritis, heart disease, autoimmune disease, and inflammatory bowel disease. The inflammatory process refers to a chain of events that occur in the body in response to trauma or injury. Inflammation can be acute or chronic. It leads to changes in the cells, tissues, and blood vessels surrounding the inflamed area.

This combination of herbs may help support conditions associated with inflammation and pain. This formulation does not possess the unpleasant gastric side effects exhibited by anti-inflammatory drugs. Some researched ingredients in this formulation support use in treating various types of arthritis. An active ingredient, turmeric inhibits the formation of the pro-inflammatory mediators thromboxane and prostaglandin.

OMEGA 3D is a blend of non-GMO natural oils from Fish that combines the health benefits of Omega 3 and Vitamin D3. It is a comprehensive “multi” fatty acid supplement that is rich in EPA, DHA and Vitamin D3.• It provides a healthy balance of essential fatty acids that are critical to total body health. These fatty acids play a vital role in the structure of cell membranes, healthy hair and skin, and support cardiovascular, nerve, neurological and immune system functions.• It also provides the desirable ratio of Omega 3 to Vitamin D3 for more efficient and beneficialprostaglandin production.

ReferencesKendall, Roger G. Building Wellness with DMG. Freedom Press, CA. 2003Golini, Jeff. “Controlled Case Study with Kre-Celazine®” Performing Laboratory BioCeutical Research & Development Laboratory, MontanaDivision. September 2007.Poynard T, Valterio C. Meta-analysis of hydroxyethylrutosides in the treatment of chronic venous insufficiency. Vasa 1994;23:244–50.Suzuki H, Yamamoto S, Hirayama C, et al. Cianidanol therapy for HBs-antigen-positive chronic hepatitis: a multicentre, double-blind study.Liver 1986;6:35–44.Amella M, Bronner C, Briancon F, et al. Inhibition of mast cell histamine release by flavonoids and bioflavonoids. Planta Medica 1985;51:16–20.Safayhi H, Mack T, Saieraj J, et al. Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase. J Pharmacol Exp Ther 1992;261:1143–6.Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3–7.Kulkarni RR, Patki PS, Jog VP, et al. Treatment of osteoarthritis with a herbomineral formulation: A double-blind, placebo-controlled, cross-over study. J Ethnopharmacol 1991;33:91–5.Deodhar SD, Sethi R, Srimal RC. Preliminary studies on antirheumatic activity of curcumin (diferuloyl methane). Ind J Med Res 1980;71:632–4.Srivastava KC, Mustafa T. Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypoth 1992;39:342–8.Chopra A, Lavin P, Patwardhan B, Chitre D. Randomized double blind trial of an Ayurvedic plant derived formulation for treatment of rheumatoid arthritis. J Rheumatol 2000;27:1365–72.Sontakke S, Thawani V, Pimpalkhute S, et al. Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee. Indian J Pharmacol 2007;39:27–9.Holt PR, Katz S, Kirshoff R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig Dis Sci 2005;50:2191–3.Chandra D, Gupta SS. Anti-inflammatory and anti-arthritic activity of volatile oil of curcuma longa (Haldi). Indian J Med Res 1972;60:138–42.Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung 1998;48:469–74.Poolsup N, Suthisisang C, Channark P, Kittikulsuth W. Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomizedcontrolled trials. Ann Pharmacother 2005;39:1080–7.Kim LS, Axelrod LJ, Howard P, et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage 2006;14:286–94.Tehranzadeh J, Booya F, Root J. Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Acta Radiol 2005;46:288-96 [review].Akhtar NM, Naseer R, Farooqi AZ, et al. Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee - a double-blind prospective randomized study. Clin Rheumatol 2004;23:410–5.

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