ntp.niehs.nih.gov · f1_m3 c number: c20107 lock date: 02/26/2008 cage range: all date range: all...
TRANSCRIPT
F1_M3C Number: C20107
Lock Date: 02/26/2008
Cage Range: ALL
Date Range: ALL
Reasons For Removal: ALL
Removal Date Range: ALL
Treatment Groups: Include ALL
Study Gender: Both
TDMSE Version: 2.3.0
PWG Approval Date: NONE
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
Note: Animals arranged according to days on test.
DAY ON TEST
B6C3F1 MICE MALE
0004
0004
0156
0548
0561
0562
0584
0588
0591
0643
0655
0678
0685
0698
0726
0727
0730
0730
0730
0731
0731
0731
0731
0731
0731
0 MG/KGANIMAL ID
00006
00020
00026
00038
00008
00007
00021
00010
00032
00049
00043
00040
00022
00012
00050
00003
00009
00024
00025
00001
00002
00005
00011
00014
00015
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + M + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Islets, Pancreatic XHemangiosarcoma X XHepatoblastomaHepatocellular Adenoma X X X X XHepatocellular Adenoma, Multiple X X X X X X XHepatocellular Carcinoma X X X X X XHepatocellular Carcinoma, Multiple X X X X
Mesentery + +
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 2
DAY ON TEST
B6C3F1 MICE MALE
0004
0004
0156
0548
0561
0562
0584
0588
0591
0643
0655
0678
0685
0698
0726
0727
0730
0730
0730
0731
0731
0731
0731
0731
0731
0 MG/KGANIMAL ID
00006
00020
00026
00038
00008
00007
00021
00010
00032
00049
00043
00040
00022
00012
00050
00003
00009
00024
00025
00001
00002
00005
00011
00014
00015
males(cont...)
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Squamous Cell Papilloma
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
Tongue +
Tooth + + + + + + + + + + + + + + + +Odontoma X XOdontoma, Multiple
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma, Metastatic, Zymbal'S Gland XHemangiosarcoma
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Subcapsular, Adenoma X X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +AdenomaCarcinoma X
Parathyroid Gland + + + + + + + M + + + M + + + + + + + + + M + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 3
DAY ON TEST
B6C3F1 MICE MALE
0004
0004
0156
0548
0561
0562
0584
0588
0591
0643
0655
0678
0685
0698
0726
0727
0730
0730
0730
0731
0731
0731
0731
0731
0731
0 MG/KGANIMAL ID
00006
00020
00026
00038
00008
00007
00021
00010
00032
00049
00043
00040
00022
00012
00050
00003
00009
00024
00025
00001
00002
00005
00011
00014
00015
males(cont...)
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Follicular Cell, Adenoma
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +
Testes + + + + + + + + + + + + + + + + + + + + + + + + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node + +
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X
Spleen + + + + + + + A + + + + + + + A + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 4
DAY ON TEST
B6C3F1 MICE MALE
0004
0004
0156
0548
0561
0562
0584
0588
0591
0643
0655
0678
0685
0698
0726
0727
0730
0730
0730
0731
0731
0731
0731
0731
0731
0 MG/KGANIMAL ID
00006
00020
00026
00038
00008
00007
00021
00010
00032
00049
00043
00040
00022
00012
00050
00003
00009
00024
00025
00001
00002
00005
00011
00014
00015
males(cont...)
Hemangiosarcoma
Thymus + + + + + + + + + + + + M + + + + + + + + + + + +Carcinoma, Metastatic, Zymbal'S Gland X
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, Lipoma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X XAlveolar/Bronchiolar CarcinomaCarcinoma, Metastatic, Zymbal'S Gland XHemangiosarcomaHepatocellular Carcinoma, Metastatic, Liver X X X X
Nose + + + + + + + A + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 5
DAY ON TEST
B6C3F1 MICE MALE
0004
0004
0156
0548
0561
0562
0584
0588
0591
0643
0655
0678
0685
0698
0726
0727
0730
0730
0730
0731
0731
0731
0731
0731
0731
0 MG/KGANIMAL ID
00006
00020
00026
00038
00008
00007
00021
00010
00032
00049
00043
00040
00022
00012
00050
00003
00009
00024
00025
00001
00002
00005
00011
00014
00015
males(cont...)
SPECIAL SENSES SYSTEM
Ear
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X X X X XBilateral, Adenoma
Zymbal's Gland +Carcinoma X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Renal Tubule, Adenoma X
Ureter +
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X X
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 6
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0 MG/KGANIMAL ID
00016
00017
00018
00023
00029
00030
00031
00034
00039
00041
00042
00044
00045
00046
00004
00013
00019
00027
00028
00033
00035
00036
00037
00047
00048 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 49
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Carcinoma, Metastatic, Islets, Pancreatic 1Hemangiosarcoma X X X X 6Hepatoblastoma X 1Hepatocellular Adenoma X X X X X X X 12Hepatocellular Adenoma, Multiple X X X X X X X X X X 17Hepatocellular Carcinoma X X X X X X X X X 15Hepatocellular Carcinoma, Multiple X X X 7
Mesentery + + 4
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 7
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0 MG/KGANIMAL ID
00016
00017
00018
00023
00029
00030
00031
00034
00039
00041
00042
00044
00045
00046
00004
00013
00019
00027
00028
00033
00035
00036
00037
00047
00048 * TOTALS
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Squamous Cell Papilloma X 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Tongue + 2
Tooth + + + + + + + + + + + + + + + + + + + + + 37Odontoma X 3Odontoma, Multiple X X 2
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Carcinoma, Metastatic, Zymbal'S Gland 1Hemangiosarcoma X 1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcapsular, Adenoma X 3
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1Carcinoma 1
Parathyroid Gland + + + M M M M M + M + + + + + M + + + + + + + + + 40
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 8
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0 MG/KGANIMAL ID
00016
00017
00018
00023
00029
00030
00031
00034
00039
00041
00042
00044
00045
00046
00004
00013
00019
00027
00028
00033
00035
00036
00037
00047
00048 * TOTALS
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Follicular Cell, Adenoma X 1
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node 2
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 1
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 48
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 9
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0 MG/KGANIMAL ID
00016
00017
00018
00023
00029
00030
00031
00034
00039
00041
00042
00044
00045
00046
00004
00013
00019
00027
00028
00033
00035
00036
00037
00047
00048 * TOTALS
Hemangiosarcoma X X X 3
Thymus M + + + + + + + + + + + + + + + + + + + + + + + + 48Carcinoma, Metastatic, Zymbal'S Gland 1
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Lipoma 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X X X X X 11Alveolar/Bronchiolar Carcinoma X X 2Carcinoma, Metastatic, Zymbal'S Gland 1Hemangiosarcoma X 1Hepatocellular Carcinoma, Metastatic, Liver X X 6
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 49
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 10
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0 MG/KGANIMAL ID
00016
00017
00018
00023
00029
00030
00031
00034
00039
00041
00042
00044
00045
00046
00004
00013
00019
00027
00028
00033
00035
00036
00037
00047
00048 * TOTALS
SPECIAL SENSES SYSTEM
Ear + 1
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X X X X X 10Bilateral, Adenoma X 1
Zymbal's Gland 1Carcinoma 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Renal Tubule, Adenoma 1
Ureter 1
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X 4
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 11
DAY ON TEST
B6C3F1 MICE MALE
0539
0550
0555
0568
0578
0586
0599
0659
0666
0694
0697
0702
0704
0714
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
6 MG/KGANIMAL ID
00065
00074
00090
00092
00079
00070
00096
00068
00087
00076
00058
00086
00085
00053
00063
00064
00066
00069
00072
00077
00083
00052
00054
00055
00056
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Fibrous Histiocytoma, Metastatic, Skin XHemangiosarcoma XHepatoblastoma X X XHepatocellular Adenoma X X X X X X X XHepatocellular Adenoma, Multiple X X X X X X XHepatocellular Carcinoma X X X X X X X X X XHepatocellular Carcinoma, Multiple X X X
Mesentery +
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 12
DAY ON TEST
B6C3F1 MICE MALE
0539
0550
0555
0568
0578
0586
0599
0659
0666
0694
0697
0702
0704
0714
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
6 MG/KGANIMAL ID
00065
00074
00090
00092
00079
00070
00096
00068
00087
00076
00058
00086
00085
00053
00063
00064
00066
00069
00072
00077
00083
00052
00054
00055
00056
males(cont...)
Hepatocellular Carcinoma, Metastatic, Liver
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Squamous Cell Papilloma
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
Tooth + + + + + + + + + + + + + + + + +Odontoma X
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Bilateral, Subcapsular, AdenomaSubcapsular, Adenoma X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +AdenomaAdenoma, Multiple
Parathyroid Gland + + + + + + + + + + + + + M + + + M + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 13
DAY ON TEST
B6C3F1 MICE MALE
0539
0550
0555
0568
0578
0586
0599
0659
0666
0694
0697
0702
0704
0714
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
6 MG/KGANIMAL ID
00065
00074
00090
00092
00079
00070
00096
00068
00087
00076
00058
00086
00085
00053
00063
00064
00066
00069
00072
00077
00083
00052
00054
00055
00056
males(cont...)
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Coagulating Gland +
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +
Testes + + + + + + + + + + + + + + + + + + + + + + + + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node + +
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X
Thymus + + + + + + + + + + M + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 14
DAY ON TEST
B6C3F1 MICE MALE
0539
0550
0555
0568
0578
0586
0599
0659
0666
0694
0697
0702
0704
0714
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
6 MG/KGANIMAL ID
00065
00074
00090
00092
00079
00070
00096
00068
00087
00076
00058
00086
00085
00053
00063
00064
00066
00069
00072
00077
00083
00052
00054
00055
00056
males(cont...)
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, Fibrous Histiocytoma XSubcutaneous Tissue, LipomaSubcutaneous Tissue, Melanoma Malignant X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Skeletal Muscle
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X X X XAlveolar/Bronchiolar Adenoma, Multiple X XAlveolar/Bronchiolar Carcinoma XAlveolar/Bronchiolar Carcinoma, Multiple XHepatoblastoma, Metastatic, Liver XHepatocellular Carcinoma, Metastatic, Liver X X XOsteosarcoma, Metastatic, Uncertain Primary
SiteX
Bronchus, Adenoma X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 15
DAY ON TEST
B6C3F1 MICE MALE
0539
0550
0555
0568
0578
0586
0599
0659
0666
0694
0697
0702
0704
0714
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
6 MG/KGANIMAL ID
00065
00074
00090
00092
00079
00070
00096
00068
00087
00076
00058
00086
00085
00053
00063
00064
00066
00069
00072
00077
00083
00052
00054
00055
00056
males(cont...)
Respiratory Epithelium, Adenoma
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X XCarcinoma X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocellular Carcinoma, Metastatic, Liver
Urethra +
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 16
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
6 MG/KGANIMAL ID
00057
00059
00060
00061
00075
00080
00081
00088
00089
00093
00094
00051
00062
00067
00071
00073
00078
00082
00084
00091
00095
00097
00098
00099
00100 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrous Histiocytoma, Metastatic, Skin 1Hemangiosarcoma X 2Hepatoblastoma X X 5Hepatocellular Adenoma X X X X X X X 15Hepatocellular Adenoma, Multiple X X X X X X X X X X X X 19Hepatocellular Carcinoma X X X X X X X X 18Hepatocellular Carcinoma, Multiple X X X X 7
Mesentery + + 3
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 17
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
6 MG/KGANIMAL ID
00057
00059
00060
00061
00075
00080
00081
00088
00089
00093
00094
00051
00062
00067
00071
00073
00078
00082
00084
00091
00095
00097
00098
00099
00100 * TOTALS
Hepatocellular Carcinoma, Metastatic, Liver X 1
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Squamous Cell Papilloma X 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Tooth + + + + + + + + + + + + + + + + + + + + + 38Odontoma 1
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Bilateral, Subcapsular, Adenoma X 1Subcapsular, Adenoma X X X 4
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1Adenoma, Multiple X 1
Parathyroid Gland + M + + + + + + + + + M + M + + + + + + + + M + M 43
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 18
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
6 MG/KGANIMAL ID
00057
00059
00060
00061
00075
00080
00081
00088
00089
00093
00094
00051
00062
00067
00071
00073
00078
00082
00084
00091
00095
00097
00098
00099
00100 * TOTALS
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Coagulating Gland 1
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node + 3
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 1
Thymus + + + + + + + + + + + + + + + + + M + + + + + + + 48
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 19
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
6 MG/KGANIMAL ID
00057
00059
00060
00061
00075
00080
00081
00088
00089
00093
00094
00051
00062
00067
00071
00073
00078
00082
00084
00091
00095
00097
00098
00099
00100 * TOTALS
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Fibrous Histiocytoma 1Subcutaneous Tissue, Lipoma X 1Subcutaneous Tissue, Melanoma Malignant 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skeletal Muscle + 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X X X 11Alveolar/Bronchiolar Adenoma, Multiple X X X 5Alveolar/Bronchiolar Carcinoma X 2Alveolar/Bronchiolar Carcinoma, Multiple 1Hepatoblastoma, Metastatic, Liver X 2Hepatocellular Carcinoma, Metastatic, Liver X X 5Osteosarcoma, Metastatic, Uncertain Primary
Site1
Bronchus, Adenoma 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 20
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
6 MG/KGANIMAL ID
00057
00059
00060
00061
00075
00080
00081
00088
00089
00093
00094
00051
00062
00067
00071
00073
00078
00082
00084
00091
00095
00097
00098
00099
00100 * TOTALS
Respiratory Epithelium, Adenoma X 1
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X X X X X 7Carcinoma 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocellular Carcinoma, Metastatic, Liver X 1
Urethra 1
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X X X X 6
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 21
DAY ON TEST
B6C3F1 MICE MALE
0402
0442
0449
0512
0548
0554
0597
0598
0609
0655
0655
0669
0672
0674
0681
0688
0693
0710
0723
0730
0730
0730
0730
0730
0731
20 MG/KGANIMAL ID
00144
00138
00125
00109
00105
00140
00136
00104
00133
00101
00116
00124
00118
00145
00147
00107
00108
00150
00149
00106
00120
00121
00134
00143
00102
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + M + + + + + + + + + + + + + M + + M + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +HemangiomaHemangiosarcoma X X X XHepatoblastoma X X X X XHepatoblastoma, Multiple XHepatocellular Adenoma X X X X X X XHepatocellular Adenoma, Multiple X X X X X X X XHepatocellular Carcinoma X X X X X X X X X XHepatocellular Carcinoma, Multiple X X X X X X XHepatocholangiocarcinoma X
Mesentery + + +Fat, Hepatocholangiocarcinoma, Metastatic,
LiverX
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 22
DAY ON TEST
B6C3F1 MICE MALE
0402
0442
0449
0512
0548
0554
0597
0598
0609
0655
0655
0669
0672
0674
0681
0688
0693
0710
0723
0730
0730
0730
0730
0730
0731
20 MG/KGANIMAL ID
00144
00138
00125
00109
00105
00140
00136
00104
00133
00101
00116
00124
00118
00145
00147
00107
00108
00150
00149
00106
00120
00121
00134
00143
00102
males(cont...)
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocholangiocarcinoma, Metastatic, Liver X
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocholangiocarcinoma, Metastatic, Liver X
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocholangiocarcinoma, Metastatic, Liver X
Tooth + + + + + + + + + + + + + + +Odontoma X
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Subcapsular, Adenoma X
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Parathyroid Gland M + + + + + + + + + + + + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + M + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 23
DAY ON TEST
B6C3F1 MICE MALE
0402
0442
0449
0512
0548
0554
0597
0598
0609
0655
0655
0669
0672
0674
0681
0688
0693
0710
0723
0730
0730
0730
0730
0730
0731
20 MG/KGANIMAL ID
00144
00138
00125
00109
00105
00140
00136
00104
00133
00101
00116
00124
00118
00145
00147
00107
00108
00150
00149
00106
00120
00121
00134
00143
00102
males(cont...)
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocholangiocarcinoma, Metastatic, Liver X
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +
Testes + + + + + + + + + + + + + + + + + + + + + + + + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node + + + +Mediastinal, Hepatocholangiocarcinoma,
Metastatic, LiverX
Pancreatic, Hemangiosarcoma X
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Hepatocholangiocarcinoma, Metastatic, Liver X
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 24
DAY ON TEST
B6C3F1 MICE MALE
0402
0442
0449
0512
0548
0554
0597
0598
0609
0655
0655
0669
0672
0674
0681
0688
0693
0710
0723
0730
0730
0730
0730
0730
0731
20 MG/KGANIMAL ID
00144
00138
00125
00109
00105
00140
00136
00104
00133
00101
00116
00124
00118
00145
00147
00107
00108
00150
00149
00106
00120
00121
00134
00143
00102
males(cont...)
Spleen + A + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X XHemangiosarcoma, Multiple
Thymus + + + M + + + + + + + + + + + + + + + + + + + + +
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M
Skin + + + + + + + + + + + + + + + + + + + + + + + + +
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Skeletal Muscle + +Hemangiosarcoma XHepatocholangiocarcinoma, Metastatic, Liver X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X X X X X XAlveolar/Bronchiolar Adenoma, MultipleCarcinoma, Metastatic, Harderian Gland XHepatoblastoma, Metastatic, Liver X XHepatocellular Carcinoma, Metastatic, Liver X X
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 25
DAY ON TEST
B6C3F1 MICE MALE
0402
0442
0449
0512
0548
0554
0597
0598
0609
0655
0655
0669
0672
0674
0681
0688
0693
0710
0723
0730
0730
0730
0730
0730
0731
20 MG/KGANIMAL ID
00144
00138
00125
00109
00105
00140
00136
00104
00133
00101
00116
00124
00118
00145
00147
00107
00108
00150
00149
00106
00120
00121
00134
00143
00102
males(cont...)
Hepatocholangiocarcinoma, Metastatic, Liver X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X X XCarcinoma X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma XLymphoma Malignant X
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 26
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
20 MG/KGANIMAL ID
00103
00113
00126
00130
00131
00137
00139
00142
00146
00110
00111
00112
00114
00115
00117
00119
00122
00123
00127
00128
00129
00132
00135
00141
00148 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 47
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangioma X 1Hemangiosarcoma X X X X X 9Hepatoblastoma X X X 8Hepatoblastoma, Multiple X 2Hepatocellular Adenoma X X X 10Hepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X X X X X 27Hepatocellular Carcinoma X X X X 14Hepatocellular Carcinoma, Multiple X X X X X X X X X 16Hepatocholangiocarcinoma 1
Mesentery + + 5Fat, Hepatocholangiocarcinoma, Metastatic,
Liver1
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 27
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
20 MG/KGANIMAL ID
00103
00113
00126
00130
00131
00137
00139
00142
00146
00110
00111
00112
00114
00115
00117
00119
00122
00123
00127
00128
00129
00132
00135
00141
00148 * TOTALS
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocholangiocarcinoma, Metastatic, Liver 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocholangiocarcinoma, Metastatic, Liver 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocholangiocarcinoma, Metastatic, Liver 1
Tooth + + + + + + + + + + + + + + + + + + + 34Odontoma 1
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcapsular, Adenoma 1
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Parathyroid Gland + + + + + M + + + + + + + + + + + + M + + M M + + 45
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 28
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
20 MG/KGANIMAL ID
00103
00113
00126
00130
00131
00137
00139
00142
00146
00110
00111
00112
00114
00115
00117
00119
00122
00123
00127
00128
00129
00132
00135
00141
00148 * TOTALS
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X 1
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatocholangiocarcinoma, Metastatic, Liver 1
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node 4Mediastinal, Hepatocholangiocarcinoma,
Metastatic, Liver1
Pancreatic, Hemangiosarcoma 1
Lymph Node, Mandibular + + + + + + + + + + + M + + + + + + + + + + + + + 49
Lymph Node, Mesenteric + + + + + + + + + + + + M + + + + + + + + + + + + 49Hepatocholangiocarcinoma, Metastatic, Liver 1
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 29
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
20 MG/KGANIMAL ID
00103
00113
00126
00130
00131
00137
00139
00142
00146
00110
00111
00112
00114
00115
00117
00119
00122
00123
00127
00128
00129
00132
00135
00141
00148 * TOTALS
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 49Hemangiosarcoma X 3Hemangiosarcoma, Multiple X 1
Thymus M + + + + + + + + + + + + + + + + + + + + + + + + 48
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skeletal Muscle 2Hemangiosarcoma 1Hepatocholangiocarcinoma, Metastatic, Liver 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X X X X X X X 17Alveolar/Bronchiolar Adenoma, Multiple X 1Carcinoma, Metastatic, Harderian Gland 1Hepatoblastoma, Metastatic, Liver X X 4Hepatocellular Carcinoma, Metastatic, Liver X X X X X 7
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 30
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
20 MG/KGANIMAL ID
00103
00113
00126
00130
00131
00137
00139
00142
00146
00110
00111
00112
00114
00115
00117
00119
00122
00123
00127
00128
00129
00132
00135
00141
00148 * TOTALS
Hepatocholangiocarcinoma, Metastatic, Liver 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 4Carcinoma 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 1Lymphoma Malignant 1
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 31
DAY ON TEST
B6C3F1 MICE MALE
0256
0449
0562
0580
0609
0623
0638
0655
0665
0669
0672
0672
0682
0693
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
60 MG/KGANIMAL ID
00163
00162
00166
00188
00173
00167
00200
00199
00158
00172
00168
00185
00176
00189
00152
00160
00165
00171
00174
00177
00179
00187
00153
00156
00157
males(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + + + + + + M + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +AdenomaCarcinoma, Multiple X
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X XHepatoblastoma X X X X X XHepatocellular Adenoma X X X X X XHepatocellular Adenoma, Multiple X X X X X X X X X X XHepatocellular Carcinoma X X X X X X X X XHepatocellular Carcinoma, Multiple X X X X X X X XHepatocholangiocarcinoma
Mesentery + +
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 32
DAY ON TEST
B6C3F1 MICE MALE
0256
0449
0562
0580
0609
0623
0638
0655
0665
0669
0672
0672
0682
0693
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
60 MG/KGANIMAL ID
00163
00162
00166
00188
00173
00167
00200
00199
00158
00172
00168
00185
00176
00189
00152
00160
00165
00171
00174
00177
00179
00187
00153
00156
00157
males(cont...)
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Squamous Cell Papilloma X
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
Tooth + + + + + + + + + + + + + + + +
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +AdenomaSubcapsular, Adenoma
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Pheochromocytoma Benign
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Parathyroid Gland + + + M + + + + + M + + + + + + + + + + M M + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 33
DAY ON TEST
B6C3F1 MICE MALE
0256
0449
0562
0580
0609
0623
0638
0655
0665
0669
0672
0672
0682
0693
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
60 MG/KGANIMAL ID
00163
00162
00166
00188
00173
00167
00200
00199
00158
00172
00168
00185
00176
00189
00152
00160
00165
00171
00174
00177
00179
00187
00153
00156
00157
males(cont...)
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + +
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Prostate + + + + + + + + + + + + + + + + + + + + + + + + +
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + +
Testes + + + + + + + + + + + + + + + + + + + + + + + + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma X
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma
Thymus + + + + + + + + + + + + + + + + + + + + + + + + +
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M
Skin + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 34
DAY ON TEST
B6C3F1 MICE MALE
0256
0449
0562
0580
0609
0623
0638
0655
0665
0669
0672
0672
0682
0693
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
60 MG/KGANIMAL ID
00163
00162
00166
00188
00173
00167
00200
00199
00158
00172
00168
00185
00176
00189
00152
00160
00165
00171
00174
00177
00179
00187
00153
00156
00157
males(cont...)
Subcutaneous Tissue, Fibrosarcoma X
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Skeletal Muscle + +Sarcoma X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X X XAlveolar/Bronchiolar Carcinoma X XHepatoblastoma, Metastatic, Liver X XHepatocellular Carcinoma, Metastatic, Liver X X X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma
URINARY SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 35
DAY ON TEST
B6C3F1 MICE MALE
0256
0449
0562
0580
0609
0623
0638
0655
0665
0669
0672
0672
0682
0693
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
60 MG/KGANIMAL ID
00163
00162
00166
00188
00173
00167
00200
00199
00158
00172
00168
00185
00176
00189
00152
00160
00165
00171
00174
00177
00179
00187
00153
00156
00157
males(cont...)
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Hemangioma X
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 36
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
60 MG/KGANIMAL ID
00169
00178
00180
00182
00184
00191
00192
00194
00196
00151
00154
00155
00159
00161
00164
00170
00175
00181
00183
00186
00190
00193
00195
00197
00198 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 49
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1Carcinoma, Multiple 1
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X 3Hepatoblastoma X X 8Hepatocellular Adenoma X X X X 10Hepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X 26Hepatocellular Carcinoma X X X X X 14Hepatocellular Carcinoma, Multiple X X X X X X X X X X X X X X 22Hepatocholangiocarcinoma X 1
Mesentery 2
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 37
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
60 MG/KGANIMAL ID
00169
00178
00180
00182
00184
00191
00192
00194
00196
00151
00154
00155
00159
00161
00164
00170
00175
00181
00183
00186
00190
00193
00195
00197
00198 * TOTALS
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Squamous Cell Papilloma X X 3
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Tooth + + + + + + + + + + + + + + 30
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1Subcapsular, Adenoma X 1
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50Pheochromocytoma Benign X 1
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Parathyroid Gland + + M M + + + + + + + + + + + + + + + M M + + + + 42
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
GENERAL BODY SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 38
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
60 MG/KGANIMAL ID
00169
00178
00180
00182
00184
00191
00192
00194
00196
00151
00154
00155
00159
00161
00164
00170
00175
00181
00183
00186
00190
00193
00195
00197
00198 * TOTALS
NONE
GENITAL SYSTEM
Epididymis + + + + + + + + + + + + + + + + + + + + + + + + + 50
Preputial Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Prostate + + + + + + + + + + + + + + + + + + + + + + + + + 50
Seminal Vesicle + + + + + + + + + + + + + + + + + + + + + + + + + 50
Testes + + + + + + + + + + + + + + + + + + + + + + + + + 50
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma 1
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangiosarcoma X 1
Thymus + + + + + + + + + + + + + + + + + + + + + + M + + 49
INTEGUMENTARY SYSTEM
Mammary Gland M M M M M M M M M M M M M M M M M M M M M M M M M 0
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 39
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
60 MG/KGANIMAL ID
00169
00178
00180
00182
00184
00191
00192
00194
00196
00151
00154
00155
00159
00161
00164
00170
00175
00181
00183
00186
00190
00193
00195
00197
00198 * TOTALS
Subcutaneous Tissue, Fibrosarcoma 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skeletal Muscle 2Sarcoma 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X X X 10Alveolar/Bronchiolar Carcinoma X X 4Hepatoblastoma, Metastatic, Liver X X X 5Hepatocellular Carcinoma, Metastatic, Liver 3
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X X 2
URINARY SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 40
DAY ON TEST
B6C3F1 MICE MALE
0731
0731
0731
0731
0731
0731
0731
0731
0731
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
0732
60 MG/KGANIMAL ID
00169
00178
00180
00182
00184
00191
00192
00194
00196
00151
00154
00155
00159
00161
00164
00170
00175
00181
00183
00186
00190
00193
00195
00197
00198 * TOTALS
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangioma 1
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X 1
*** END OF MALE DATA ***
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 41
DAY ON TEST
B6C3F1 MICE FEMALE
0444
0642
0645
0663
0666
0666
0698
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0 MG/KGANIMAL ID
00222
00248
00211
00250
00236
00246
00227
00203
00204
00205
00206
00207
00210
00212
00214
00217
00220
00221
00224
00225
00234
00237
00242
00243
00247
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hemangioma XHepatocellular Adenoma X X X X X X X XHepatocellular Adenoma, MultipleHepatocellular Carcinoma X X X XHepatocellular Carcinoma, Multiple
Mesentery +
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 42
DAY ON TEST
B6C3F1 MICE FEMALE
0444
0642
0645
0663
0666
0666
0698
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0 MG/KGANIMAL ID
00222
00248
00211
00250
00236
00246
00227
00203
00204
00205
00206
00207
00210
00212
00214
00217
00220
00221
00224
00225
00234
00237
00242
00243
00247
females(cont...)
Squamous Cell Papilloma X
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
Tooth + + + +
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Pheochromocytoma Benign X
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 43
DAY ON TEST
B6C3F1 MICE FEMALE
0444
0642
0645
0663
0666
0666
0698
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0 MG/KGANIMAL ID
00222
00248
00211
00250
00236
00246
00227
00203
00204
00205
00206
00207
00210
00212
00214
00217
00220
00221
00224
00225
00234
00237
00242
00243
00247
females(cont...)
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Cystadenoma XTubulostromal Adenoma
Uterus + + + + + + + + + + + + + + + + + + + + + + + + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node + +
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node, Mesenteric + + + + A + + + + + + + + + + + + + + + + + + + +
Spleen + + + + A + + + + + + + + + + + + + + + + + + + +
Thymus + + + + + + + + + + + + + + + + + + + + + + + + +
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Keratoacanthoma XSubcutaneous Tissue, Fibrosarcoma XSubcutaneous Tissue, Fibrosarcoma, Multiple X
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 44
DAY ON TEST
B6C3F1 MICE FEMALE
0444
0642
0645
0663
0666
0666
0698
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0 MG/KGANIMAL ID
00222
00248
00211
00250
00236
00246
00227
00203
00204
00205
00206
00207
00210
00212
00214
00217
00220
00221
00224
00225
00234
00237
00242
00243
00247
females(cont...)
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma, MultipleHepatocellular Carcinoma, Metastatic, Liver X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 45
DAY ON TEST
B6C3F1 MICE FEMALE
0444
0642
0645
0663
0666
0666
0698
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0 MG/KGANIMAL ID
00222
00248
00211
00250
00236
00246
00227
00203
00204
00205
00206
00207
00210
00212
00214
00217
00220
00221
00224
00225
00234
00237
00242
00243
00247
females(cont...)
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Lymphoma Malignant X X X X X X X
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 46
DAY ON TEST
B6C3F1 MICE FEMALE
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0 MG/KGANIMAL ID
00201
00202
00209
00213
00215
00216
00223
00226
00228
00229
00230
00231
00233
00235
00238
00239
00241
00245
00249
00208
00218
00219
00232
00240
00244 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangioma 1Hepatocellular Adenoma X X X X X X X 15Hepatocellular Adenoma, Multiple X X 2Hepatocellular Carcinoma X 5Hepatocellular Carcinoma, Multiple X 1
Mesentery + + 3
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma 1
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 47
DAY ON TEST
B6C3F1 MICE FEMALE
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0 MG/KGANIMAL ID
00201
00202
00209
00213
00215
00216
00223
00226
00228
00229
00230
00231
00233
00235
00238
00239
00241
00245
00249
00208
00218
00219
00232
00240
00244 * TOTALS
Squamous Cell Papilloma 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Tooth + + + + + + + + + 13
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50Pheochromocytoma Benign X 2
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Parathyroid Gland + + + + + + + + + + + + + + + + + + + + + + + M M 48
Pituitary Gland + + + + M M + + + + + + + + + + + + + + + + + + + 48
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 48
DAY ON TEST
B6C3F1 MICE FEMALE
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0 MG/KGANIMAL ID
00201
00202
00209
00213
00215
00216
00223
00226
00228
00229
00230
00231
00233
00235
00238
00239
00241
00245
00249
00208
00218
00219
00232
00240
00244 * TOTALS
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50Cystadenoma 1Tubulostromal Adenoma X 1
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node + + + + + 7
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 49
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 49
Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 50
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Carcinoma X 1
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Keratoacanthoma 1Subcutaneous Tissue, Fibrosarcoma 1Subcutaneous Tissue, Fibrosarcoma, Multiple 1
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 49
DAY ON TEST
B6C3F1 MICE FEMALE
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0 MG/KGANIMAL ID
00201
00202
00209
00213
00215
00216
00223
00226
00228
00229
00230
00231
00233
00235
00238
00239
00241
00245
00249
00208
00218
00219
00232
00240
00244 * TOTALS
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma, Multiple X X 2Hepatocellular Carcinoma, Metastatic, Liver X 2
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 50
DAY ON TEST
B6C3F1 MICE FEMALE
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0 MG/KGANIMAL ID
00201
00202
00209
00213
00215
00216
00223
00226
00228
00229
00230
00231
00233
00235
00238
00239
00241
00245
00249
00208
00218
00219
00232
00240
00244 * TOTALS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Lymphoma Malignant X X X X X X X X 15
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 51
DAY ON TEST
B6C3F1 MICE FEMALE
0008
0449
0509
0555
0621
0671
0700
0704
0720
0723
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
6 MG/KGANIMAL ID
00300
00276
00288
00277
00296
00272
00254
00287
00251
00253
00255
00258
00262
00264
00267
00268
00273
00275
00278
00281
00282
00283
00285
00291
00292
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +HemangiomaHemangiosarcomaHepatoblastoma XHepatocellular Adenoma X X X X X XHepatocellular Adenoma, Multiple XHepatocellular Carcinoma X X XHepatocellular Carcinoma, MultipleSarcoma, Metastatic, Skeletal Muscle X
Mesentery + + + + +Sarcoma XSarcoma, Metastatic, Skeletal Muscle X
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 52
DAY ON TEST
B6C3F1 MICE FEMALE
0008
0449
0509
0555
0621
0671
0700
0704
0720
0723
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
6 MG/KGANIMAL ID
00300
00276
00288
00277
00296
00272
00254
00287
00251
00253
00255
00258
00262
00264
00267
00268
00273
00275
00278
00281
00282
00283
00285
00291
00292
females(cont...)
Sarcoma, Metastatic, Skeletal Muscle X
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +Squamous Cell Carcinoma XSquamous Cell Papilloma X XSquamous Cell Papilloma, Multiple
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma X
Tooth + + + +
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +Sarcoma, Metastatic, Skeletal Muscle X
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Parathyroid Gland M + + + + + + + + + M + + + + M + M + + + + + + M
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Pars Distalis, Adenoma
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 53
DAY ON TEST
B6C3F1 MICE FEMALE
0008
0449
0509
0555
0621
0671
0700
0704
0720
0723
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
6 MG/KGANIMAL ID
00300
00276
00288
00277
00296
00272
00254
00287
00251
00253
00255
00258
00262
00264
00267
00268
00273
00275
00278
00281
00282
00283
00285
00291
00292
females(cont...)
Pars Intermedia, Adenoma X X
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Ovary + + + + + + + M + + + + + + + + + + + + + + + + +CystadenomaLuteomaThecoma Benign
Oviduct +Sarcoma, Metastatic, Skeletal Muscle X
Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Polyp Stromal X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node + +
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node, Mesenteric A + + + + + + + + + + + + + + + + + + + + + + + +Sarcoma, Metastatic, Skeletal Muscle X
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 54
DAY ON TEST
B6C3F1 MICE FEMALE
0008
0449
0509
0555
0621
0671
0700
0704
0720
0723
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
6 MG/KGANIMAL ID
00300
00276
00288
00277
00296
00272
00254
00287
00251
00253
00255
00258
00262
00264
00267
00268
00273
00275
00278
00281
00282
00283
00285
00291
00292
females(cont...)
Spleen A + + + + + + + + + + + + + + + + + + + + + + + +Hemangiosarcoma XSarcoma, Metastatic, Skeletal Muscle X
Thymus + + + + + + + + + + + + + + + + + + + + + + + + +Sarcoma, Metastatic, Skeletal Muscle X
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Dermis, Fibrous Histiocytoma XSubcutaneous Tissue, Liposarcoma
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Skeletal Muscle +Sarcoma X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma XAlveolar/Bronchiolar Adenoma, MultipleAlveolar/Bronchiolar CarcinomaCarcinoma, Metastatic, Harderian Gland
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 55
DAY ON TEST
B6C3F1 MICE FEMALE
0008
0449
0509
0555
0621
0671
0700
0704
0720
0723
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
6 MG/KGANIMAL ID
00300
00276
00288
00277
00296
00272
00254
00287
00251
00253
00255
00258
00262
00264
00267
00268
00273
00275
00278
00281
00282
00283
00285
00291
00292
females(cont...)
Hepatocellular Carcinoma, Metastatic, Liver XSarcoma, Metastatic, Skeletal Muscle X
Nose + + A + + + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Adenoma XCarcinoma
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Sarcoma X
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma X XLymphoma Malignant X X X X X X
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 56
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
6 MG/KGANIMAL ID
00293
00295
00297
00256
00260
00261
00269
00274
00284
00289
00290
00294
00298
00252
00257
00259
00263
00265
00266
00270
00271
00279
00280
00286
00299 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangioma X 1Hemangiosarcoma X 1Hepatoblastoma 1Hepatocellular Adenoma X X X X X X X 13Hepatocellular Adenoma, Multiple X X X X X 6Hepatocellular Carcinoma X X X X X X X 10Hepatocellular Carcinoma, Multiple X X X 3Sarcoma, Metastatic, Skeletal Muscle 1
Mesentery + + + 8Sarcoma 1Sarcoma, Metastatic, Skeletal Muscle 1
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 57
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
6 MG/KGANIMAL ID
00293
00295
00297
00256
00260
00261
00269
00274
00284
00289
00290
00294
00298
00252
00257
00259
00263
00265
00266
00270
00271
00279
00280
00286
00299 * TOTALS
Sarcoma, Metastatic, Skeletal Muscle 1
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50Squamous Cell Carcinoma 1Squamous Cell Papilloma X X 4Squamous Cell Papilloma, Multiple X 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma 1
Tooth + + + + + + 10
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 49
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50Sarcoma, Metastatic, Skeletal Muscle 1
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Parathyroid Gland + + + M + + + M M + + + + + + + + M + M M M + + + 38
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Pars Distalis, Adenoma X X 2
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 58
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
6 MG/KGANIMAL ID
00293
00295
00297
00256
00260
00261
00269
00274
00284
00289
00290
00294
00298
00252
00257
00259
00263
00265
00266
00270
00271
00279
00280
00286
00299 * TOTALS
Pars Intermedia, Adenoma X 3
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 49Cystadenoma X X 2Luteoma X 1Thecoma Benign X 1
Oviduct 1Sarcoma, Metastatic, Skeletal Muscle 1
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50Polyp Stromal X 2
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node + 3
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 49Sarcoma, Metastatic, Skeletal Muscle 1
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 59
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
6 MG/KGANIMAL ID
00293
00295
00297
00256
00260
00261
00269
00274
00284
00289
00290
00294
00298
00252
00257
00259
00263
00265
00266
00270
00271
00279
00280
00286
00299 * TOTALS
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 49Hemangiosarcoma 1Sarcoma, Metastatic, Skeletal Muscle 1
Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 50Sarcoma, Metastatic, Skeletal Muscle 1
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Dermis, Fibrous Histiocytoma 1Subcutaneous Tissue, Liposarcoma X 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skeletal Muscle + 2Sarcoma 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X 3Alveolar/Bronchiolar Adenoma, Multiple X 1Alveolar/Bronchiolar Carcinoma X 1Carcinoma, Metastatic, Harderian Gland X 1
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 60
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
6 MG/KGANIMAL ID
00293
00295
00297
00256
00260
00261
00269
00274
00284
00289
00290
00294
00298
00252
00257
00259
00263
00265
00266
00270
00271
00279
00280
00286
00299 * TOTALS
Hepatocellular Carcinoma, Metastatic, Liver X X 3Sarcoma, Metastatic, Skeletal Muscle 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 49
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X X X X X 6Carcinoma X 1
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50Sarcoma 1
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 2Lymphoma Malignant X X X 9
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 61
DAY ON TEST
B6C3F1 MICE FEMALE
0011
0253
0501
0585
0627
0649
0660
0669
0703
0709
0715
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
20 MG/KGANIMAL ID
00340
00314
00330
00317
00320
00332
00301
00342
00348
00303
00335
00302
00306
00307
00312
00313
00316
00319
00321
00323
00324
00333
00336
00337
00338
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + M + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +HemangiomaHemangiosarcoma XHepatocellular Adenoma X XHepatocellular Adenoma, Multiple X X X X X X X X X X X X X XHepatocellular Carcinoma X X X XHepatocellular Carcinoma, Multiple X X X
Mesentery + + +
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 62
DAY ON TEST
B6C3F1 MICE FEMALE
0011
0253
0501
0585
0627
0649
0660
0669
0703
0709
0715
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
20 MG/KGANIMAL ID
00340
00314
00330
00317
00320
00332
00301
00342
00348
00303
00335
00302
00306
00307
00312
00313
00316
00319
00321
00323
00324
00333
00336
00337
00338
females(cont...)
Squamous Cell Papilloma X XSquamous Cell Papilloma, Multiple
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
Tooth + + + +
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Parathyroid Gland M M + + + + + M + + + + + M + + + + + + M M + + +
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Pars Distalis, Adenoma X
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 63
DAY ON TEST
B6C3F1 MICE FEMALE
0011
0253
0501
0585
0627
0649
0660
0669
0703
0709
0715
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
20 MG/KGANIMAL ID
00340
00314
00330
00317
00320
00332
00301
00342
00348
00303
00335
00302
00306
00307
00312
00313
00316
00319
00321
00323
00324
00333
00336
00337
00338
females(cont...)
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Cystadenoma X
Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma XFibrous Histiocytoma XPolyp Stromal XSarcoma Stromal XSquamous Cell Carcinoma X
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node + + +
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node, Mesenteric + A + + + + + + + + + + + + + + + + + + + + + + +
Spleen + A + + + + + + + + + + + + + + + + + + + + + + +
Thymus + + + + + + + + M + + + + + + + + + + + + + + + +
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +Carcinoma X
Skin + + + + + + + + + + + + + + + + + + + + + + + + +Subcutaneous Tissue, Fibrosarcoma
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 64
DAY ON TEST
B6C3F1 MICE FEMALE
0011
0253
0501
0585
0627
0649
0660
0669
0703
0709
0715
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
20 MG/KGANIMAL ID
00340
00314
00330
00317
00320
00332
00301
00342
00348
00303
00335
00302
00306
00307
00312
00313
00316
00319
00321
00323
00324
00333
00336
00337
00338
females(cont...)
Subcutaneous Tissue, Melanoma MalignantSubcutaneous Tissue, Neurofibrosarcoma XSubcutaneous Tissue, SarcomaSubcutaneous Tissue, Schwannoma Malignant
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + +
Skeletal MuscleRhabdomyosarcoma, Multiple
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + +
Peripheral Nerve +
Spinal Cord +
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X XAlveolar/Bronchiolar Adenoma, MultipleAlveolar/Bronchiolar Carcinoma XCarcinoma, Metastatic, Harderian Gland X XFibrous Histiocytoma X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 65
DAY ON TEST
B6C3F1 MICE FEMALE
0011
0253
0501
0585
0627
0649
0660
0669
0703
0709
0715
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
0729
20 MG/KGANIMAL ID
00340
00314
00330
00317
00320
00332
00301
00342
00348
00303
00335
00302
00306
00307
00312
00313
00316
00319
00321
00323
00324
00333
00336
00337
00338
females(cont...)
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +AdenomaCarcinoma X X
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Fibrous Histiocytoma X
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic Sarcoma X X XLymphoma Malignant X X X X X
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 66
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
20 MG/KGANIMAL ID
00344
00349
00304
00309
00310
00311
00318
00322
00327
00331
00341
00346
00347
00350
00305
00308
00315
00325
00326
00328
00329
00334
00339
00343
00345 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + + 49
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hemangioma X 1Hemangiosarcoma 1Hepatocellular Adenoma X X X X X X 8Hepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X 29Hepatocellular Carcinoma X X X X X X X X X 13Hepatocellular Carcinoma, Multiple X X 5
Mesentery + + + + + + 9
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 50
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 67
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
20 MG/KGANIMAL ID
00344
00349
00304
00309
00310
00311
00318
00322
00327
00331
00341
00346
00347
00350
00305
00308
00315
00325
00326
00328
00329
00334
00339
00343
00345 * TOTALS
Squamous Cell Papilloma X X X 5Squamous Cell Papilloma, Multiple X 1
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Tooth + + + 7
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Parathyroid Gland M + + + M + + + + + + + + + + + M + + M + + + M M 38
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Pars Distalis, Adenoma 1
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
GENERAL BODY SYSTEM
NONE
GENITAL SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 68
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
20 MG/KGANIMAL ID
00344
00349
00304
00309
00310
00311
00318
00322
00327
00331
00341
00346
00347
00350
00305
00308
00315
00325
00326
00328
00329
00334
00339
00343
00345 * TOTALS
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50Cystadenoma 1
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50Carcinoma 1Fibrous Histiocytoma 1Polyp Stromal X 2Sarcoma Stromal 1Squamous Cell Carcinoma 1
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node + + 5
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 49
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 49
Thymus M + + + + + + + + + + + + + + + + + + + + + + + + 48
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Carcinoma 1
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50Subcutaneous Tissue, Fibrosarcoma X 1
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 69
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
20 MG/KGANIMAL ID
00344
00349
00304
00309
00310
00311
00318
00322
00327
00331
00341
00346
00347
00350
00305
00308
00315
00325
00326
00328
00329
00334
00339
00343
00345 * TOTALS
Subcutaneous Tissue, Melanoma Malignant X 1Subcutaneous Tissue, Neurofibrosarcoma 1Subcutaneous Tissue, Sarcoma X 1Subcutaneous Tissue, Schwannoma Malignant X 1
MUSCULOSKELETAL SYSTEM
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skeletal Muscle + 1Rhabdomyosarcoma, Multiple X 1
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 50
Peripheral Nerve 1
Spinal Cord 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X X 7Alveolar/Bronchiolar Adenoma, Multiple X 1Alveolar/Bronchiolar Carcinoma X 2Carcinoma, Metastatic, Harderian Gland 2Fibrous Histiocytoma 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 70
DAY ON TEST
B6C3F1 MICE FEMALE
0729
0729
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
0731
20 MG/KGANIMAL ID
00344
00349
00304
00309
00310
00311
00318
00322
00327
00331
00341
00346
00347
00350
00305
00308
00315
00325
00326
00328
00329
00334
00339
00343
00345 * TOTALS
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 50
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Adenoma X 1Carcinoma 2
URINARY SYSTEM
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50Fibrous Histiocytoma 1
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma 3Lymphoma Malignant X X X X X X 11
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 71
DAY ON TEST
B6C3F1 MICE FEMALE
0043
0053
0386
0387
0481
0512
0570
0573
0578
0579
0602
0607
0627
0645
0699
0701
0708
0711
0729
0729
0729
0729
0729
0729
0729
60 MG/KGANIMAL ID
00391
00356
00352
00374
00368
00400
00382
00385
00383
00384
00371
00395
00360
00390
00379
00354
00389
00365
00351
00359
00362
00363
00369
00388
00394
females(cont...)
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +
Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +
Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hepatoblastoma XHepatocellular Adenoma X X X XHepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X XHepatocellular Carcinoma X X XHepatocellular Carcinoma, Multiple X X X X X X X X X
Mesentery + + +
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +
Salivary Glands + + + + + M + + + + + + + + M + + + + + + + + + +
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 72
DAY ON TEST
B6C3F1 MICE FEMALE
0043
0053
0386
0387
0481
0512
0570
0573
0578
0579
0602
0607
0627
0645
0699
0701
0708
0711
0729
0729
0729
0729
0729
0729
0729
60 MG/KGANIMAL ID
00391
00356
00352
00374
00368
00400
00382
00385
00383
00384
00371
00395
00360
00390
00379
00354
00389
00365
00351
00359
00362
00363
00369
00388
00394
females(cont...)
Squamous Cell Papilloma X
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +
Tongue
Tooth +
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +
Heart + + + + + + + + + + + + + + + + + + + + + + + + +
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +Pheochromocytoma Benign X
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +
Parathyroid Gland + M + + + M M + + M + + + + M + + + M + + + + M +
Pituitary Gland + + + + + + + + + + + + + + M + + + + + + + + + +
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Follicular Cell, Adenoma X
GENERAL BODY SYSTEM
NONE
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 73
DAY ON TEST
B6C3F1 MICE FEMALE
0043
0053
0386
0387
0481
0512
0570
0573
0578
0579
0602
0607
0627
0645
0699
0701
0708
0711
0729
0729
0729
0729
0729
0729
0729
60 MG/KGANIMAL ID
00391
00356
00352
00374
00368
00400
00382
00385
00383
00384
00371
00395
00360
00390
00379
00354
00389
00365
00351
00359
00362
00363
00369
00388
00394
females(cont...)
GENITAL SYSTEM
Clitoral Gland + + + + + + + + M + + + + + + + + + + + + + + + +
Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Cystadenoma
Uterus + + + + + + + + + + + + + + + + + + + + + + + + +
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +
Lymph Node + + +Mediastinal, Osteosarcoma, Metastatic, Bone X
Lymph Node, Mandibular + + + + + M + + + + + + + + M + + + + + + + + + +Hemangioma
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +
Spleen + + + + + + + + + + + + + + + + + + + + + + + + +
Thymus + + + + + + + M + + + + M + + + + + + + + + + + +
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +
Skin + + + + + + + + + + + + + + + + + + + + + + + + +
MUSCULOSKELETAL SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 74
DAY ON TEST
B6C3F1 MICE FEMALE
0043
0053
0386
0387
0481
0512
0570
0573
0578
0579
0602
0607
0627
0645
0699
0701
0708
0711
0729
0729
0729
0729
0729
0729
0729
60 MG/KGANIMAL ID
00391
00356
00352
00374
00368
00400
00382
00385
00383
00384
00371
00395
00360
00390
00379
00354
00389
00365
00351
00359
00362
00363
00369
00388
00394
females(cont...)
Bone + + + + + + + + + + + + + + + + + + + + + + + + +Osteosarcoma X
Skeletal Muscle +Rhabdomyosarcoma X
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + M + + + + + + + + + +Meningioma Benign
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + +Alveolar/Bronchiolar Adenoma X X X X X XAlveolar/Bronchiolar Carcinoma XHepatoblastoma, Metastatic, LiverHepatocellular Carcinoma, Metastatic, Liver X XOsteosarcoma, Metastatic, Bone X
Nose + + + + + + + + + + + + + + + + + + + + + + + + +
Trachea + + + + + + + + + + + + + + + + + + + + + + + + +
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + M + + + + + + + + + +
Harderian Gland + + + + + + + + + + + + + + M + + + + + + + + + +Adenoma X X
URINARY SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 75
DAY ON TEST
B6C3F1 MICE FEMALE
0043
0053
0386
0387
0481
0512
0570
0573
0578
0579
0602
0607
0627
0645
0699
0701
0708
0711
0729
0729
0729
0729
0729
0729
0729
60 MG/KGANIMAL ID
00391
00356
00352
00374
00368
00400
00382
00385
00383
00384
00371
00395
00360
00390
00379
00354
00389
00365
00351
00359
00362
00363
00369
00388
00394
females(cont...)
Kidney + + + + + + + + + + + + + + + + + + + + + + + + +
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + +Histiocytic SarcomaLymphoma Malignant X X X X X X
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 76
DAY ON TEST
B6C3F1 MICE FEMALE
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
60 MG/KGANIMAL ID
00353
00355
00357
00358
00361
00364
00366
00367
00370
00372
00373
00376
00380
00381
00386
00387
00397
00398
00375
00377
00378
00392
00393
00396
00399 * TOTALS
ALIMENTARY SYSTEM
Esophagus + + + + + + + + + + + + + + + + + + + + + + + + + 50
Gallbladder + + + + + + + + + + + + + + + M + + + + + + + + + 49
Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + + 50
Liver + + + + + + + + + + + + + + + + + + + + + + + + + 50Hepatoblastoma X X X 4Hepatocellular Adenoma X X X X X 9Hepatocellular Adenoma, Multiple X X X X X X X X X X X X X X X X X X X 35Hepatocellular Carcinoma X X X X X X X X X 12Hepatocellular Carcinoma, Multiple X X X X X X X X X X 19
Mesentery + + + 6
Pancreas + + + + + + + + + + + + + + + + + + + + + + + + + 50
Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + + 48
Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + + 50
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 77
DAY ON TEST
B6C3F1 MICE FEMALE
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
60 MG/KGANIMAL ID
00353
00355
00357
00358
00361
00364
00366
00367
00370
00372
00373
00376
00380
00381
00386
00387
00397
00398
00375
00377
00378
00392
00393
00396
00399 * TOTALS
Squamous Cell Papilloma X X X X X X 7
Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + + 50
Tongue + 1
Tooth + + + 4
CARDIOVASCULAR SYSTEM
Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + + 50
Heart + + + + + + + + + + + + + + + + + + + + + + + + + 50
ENDOCRINE SYSTEM
Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + + 50
Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + + 50Pheochromocytoma Benign X 2
Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + + 50
Parathyroid Gland M M + + M + + M + M M M + M M + + + + + + + + + + 34
Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50Follicular Cell, Adenoma 1
GENERAL BODY SYSTEM
NONE
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 78
DAY ON TEST
B6C3F1 MICE FEMALE
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
60 MG/KGANIMAL ID
00353
00355
00357
00358
00361
00364
00366
00367
00370
00372
00373
00376
00380
00381
00386
00387
00397
00398
00375
00377
00378
00392
00393
00396
00399 * TOTALS
GENITAL SYSTEM
Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49
Ovary + + + + + + + + + + + + + + + + + + + + + + + + + 50Cystadenoma X 1
Uterus + + + + + + + + + + + + + + + + + + + + + + + + + 50
HEMATOPOIETIC SYSTEM
Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + 49
Lymph Node + 4Mediastinal, Osteosarcoma, Metastatic, Bone 1
Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + + 48Hemangioma X 1
Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + + 50
Spleen + + + + + + + + + + + + + + + + + + + + + + + + + 50
Thymus + + + + + + + + + + + + + + + + + + + + + + + + + 48
INTEGUMENTARY SYSTEM
Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + + 50
Skin + + + + + + + + + + + + + + + + + + + + + + + + + 50
MUSCULOSKELETAL SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 79
DAY ON TEST
B6C3F1 MICE FEMALE
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
60 MG/KGANIMAL ID
00353
00355
00357
00358
00361
00364
00366
00367
00370
00372
00373
00376
00380
00381
00386
00387
00397
00398
00375
00377
00378
00392
00393
00396
00399 * TOTALS
Bone + + + + + + + + + + + + + + + + + + + + + + + + + 50Osteosarcoma 1
Skeletal Muscle + 2Rhabdomyosarcoma X 2
NERVOUS SYSTEM
Brain + + + + + + + + + + + + + + + + + + + + + + + + + 49Meningioma Benign X 1
RESPIRATORY SYSTEM
Lung + + + + + + + + + + + + + + + + + + + + + + + + + 50Alveolar/Bronchiolar Adenoma X X X X X X 12Alveolar/Bronchiolar Carcinoma 1Hepatoblastoma, Metastatic, Liver X 1Hepatocellular Carcinoma, Metastatic, Liver 2Osteosarcoma, Metastatic, Bone 1
Nose + + + + + + + + + + + + + + + + + + + + + + + + + 50
Trachea + + + + + + + + + + + + + + + + + + + + + + + + + 50
SPECIAL SENSES SYSTEM
Eye + + + + + + + + + + + + + + + + + + + + + + + + + 49
Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + + 49Adenoma X 3
URINARY SYSTEM
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 80
DAY ON TEST
B6C3F1 MICE FEMALE
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0730
0731
0731
0731
0731
0731
0731
0731
60 MG/KGANIMAL ID
00353
00355
00357
00358
00361
00364
00366
00367
00370
00372
00373
00376
00380
00381
00386
00387
00397
00398
00375
00377
00378
00392
00393
00396
00399 * TOTALS
Kidney + + + + + + + + + + + + + + + + + + + + + + + + + 50
Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + + 50
SYSTEMIC LESIONS
Multiple Organ + + + + + + + + + + + + + + + + + + + + + + + + + 50Histiocytic Sarcoma X 1Lymphoma Malignant X X 8
*** END OF REPORT ***
TDMS No. 20107 - 04 P17: NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Date Report Requested: 03/10/2011Test Type: CHRONIC N,N-Dimethyl-p-toluidine Time Report Requested: 11:42:39
Route: GAVAGE CAS Number: 99-97-8 First Dose M/F: 10/26/04 / 10/25/04Species/Strain: MICE/B6C3F1 Lab: BAT
* .. Total animals with tissue examined microscopically; Total animals with tumor M .. Missing tissue+ .. Tissue examined microscopically A .. Autolysis precludes evaluationX .. Lesion present BLANK .. Not examined microscopicallyI .. Insufficient tissue Page 81