Novocastra HD - Pulmonary PathologyHighly Definitive Antibodies

Trust the HD Difference – Highly Definitive Antibodies for Diagnostic Confidence• Independently benchmarked against leading equivalents by external QA*

• Establishing a new quality standard in IHC; simplifying antibody selection

*Independent analysis commissioned by Leica Biosystems and conducted by NordiQC according to the manufacturers’ instructions for use and on the corresponding staining platform.

Human MesotheliomaCytoplasmic staining of malignant cells.

Human Adenocarcinoma of EndometriumCytoplasmic and extracellular staining of malignant glandular endometrial cells.

Human Colonic Mucinous AdenocarcinomaCytoplasmic and membrane staining of absorbative intestinal epithelial cells and malignant tumor cells.

Calretinin Clone CAL6CA125 Clone

OV185:1Carcinoembryoinic Antigen (CD66e)

Clone COL-1

BOND 7 mL PA0346

Liquid 1 mL NCL-L-CALRET-566

BOND 7 mL PA0539 NEW

Liquid 1 mL NCL-L-CA125 NEW

BOND 7 mL PA0848 NEW

Liquid 1 mL NCL-L-CEA-609 NEW

BOND 7 mL PA0088

Human TonsilMembrane staining of epithelial cells and developing B and plasma cells.

CD138 Clone MI15

BOND 7 mL PA0191

Liquid 1 mL NCL-L-CD56-504

CD56 Clone CD564

Human Colonic AdenocarcinomaNuclear and cytoplasmic staining of malignant epithelial-derived cells.

CDX2 Clone EP25

BOND 7 mL PA0375

Cytokeratin 7 Clone RN7

BOND 7 mL PA0942

BOND 30 mL PA0138

Liquid 1 mL NCL-L-CK7-560

Cytokeratin 5 Clone XM26

BOND 7 mL PA0468

Liquid 0.5 mL NCL-L-CK5

Liquid 1 mL NCL-L-CK5

Human TonsilNK cells and CD4/CD8 double positive T cells show a weak to moderate and distinct membrane staining reaction while the majority of lymphocytes are unstained.

Ductal Carcinoma In SituIntense staining of myoepithelial cells.

Epithelial Myoepithelial CarcinomaThe luminal cells show intense staining with CK7 in comparison with the weaker staining of the abluminal (myoepithelial) cells.

Ki67 Clone MM1

BOND 7 mL PA0118

BOND 30 mL PA0410

Liquid 1 mL NCL-L-Ki67-MM1

Melan A Clone A103

BOND 7 mL PA0233

BOND 30 mL PA0044

Liquid 1 mL NCL-L-MelanA

Novocastra HD - Pulmonary Pathology

E-Cadherin Clone 36B5

BOND 7 mL PA0387

Liquid 1 mL NCL-L-E-Cad

Estrogen Receptor Clone 6F11

BOND 7 mL PA0151

BOND 30 mL PA0009

Liquid 1 mL NCL-L-ER-6F11

Liquid 2mL NCL-L-ER-6F11 N/A USA

Human LeiomyosarcomaCytoplasmic staining of malignant tumor cells.

Desmin Clone DE-R-11

BOND 7 mL PA0032

Liquid 1 mL NCL-L-DES-DERII

Invasive Breast CarcinomaClear membrane and cytoplasmic staining of tumor cells.

High Grade B Cell Immunoblastic LymphomaIntense nuclear staining in proliferating B cells.

Human Melanoma A melanoma showing cytoplasmic staining of tumor cells.

Invasive Ductal Carcinoma High ExpressorIntense nuclear staining in nearly 100% of tumor cells.

Cytokeratin 20 Clone Ks20.8

BOND 7 mL PA0022

BOND 30 mL PA0037

Liquid 0.5 mL NCL-L-CK20

Liquid 1 mL NCL-L-CK20

Human ColonIntense staining in the crypts.

BOND 7 mL PA0640

Liquid 0.5 mL NCL-L-VIM-V9

Liquid 1 mL NCL-L-VIM-V9

BOND 7 mL PA0562

Liquid 1 mL NCL-L-WT1-562

Vimentin Clone V9 Wilms’ Tumor Clone

WT49

Human Papillary Lung AdenocarcinomaPunctate cytoplasmic staining of malignant cells and infiltrating macrophages.

BOND 7 mL PA0064

Liquid 1 mL NCL-L-NAPSIN A

Napsin A Clone IP64

BOND 7 mL PA0057

Liquid 0.5 mL NCL-L-p53-D07

Liquid 1 mL NCL-L-p53-D07

p53 Clone DO-7

Human Ductal Carcinoma Intense nuclear staining of tumor cells.

Spindle Cell CarcinomaA spindle cell carcinoma showing intense vimentin staining.

Human Kidney, Wilms’ TumorNuclear staining of invasive tumor cells.

Human Pulmonary AdenocarcinomaNuclear staining of tumor cells.

BOND 7 mL PA0364

Liquid 1 mL NCL-L-TTF-1

Thyroid Transcription Factor-1

Clone SPT24

LeicaBiosystems.com

Novocastra HDHighly Definitive Antibodies

Benefits of BOND Ready-to-Use antibodies

✓ Optimized for staining performance on BOND

✓ Validated antibody concentrations

✓ Ease of use: just plug and play

✓ Increase standardization through automation

✓ Eliminate variability in antibody preparation

Benefits of concentrated liquid antibodies

✓ Flexibility of use on various platforms1

✓ Adaptable to a variety of detection systems1

✓ Adjustable concentration to suit user’s tissue1

✓ Economical option that retains confidence in clone selection

1. The performance of antibodies should be validated when used with automated platforms or manual staining systems other than stated on Instructions for Use.

Improve workflow efficiency and streamline validation.

95.13345 Rev C · 03/2016 · Copyright©2016 Leica Biosystems Newcastle Ltd. All rights reserved. LEICA and the Leica Logo are registered trademarks of Leica Microsystems IR GmbH. Novocastra and BOND are trademarks of Leica Biosystems and its affiliates. Other logos, product and/or company names might be trademarks of their respective owners. The EP clones have been created by Epitomics Inc., using Epitomics’ proprietary rabbit monoclonal antibody technology covered under Patent No.’s 5, 675, 063 and 7, 402, 409.

Independently Evaluated* Specifically SelectedEach antibody in the range has been independently evaluated* by external QA, NordiQC, in comparison with equivalent products from other vendors. The range represents the highest performing antibodies that Leica Biosystems offers for the most commonly performed IHC tests.

*Independent analysis commissioned by Leica Biosystems and conducted by NordiQC according to the manufacturers’ instructions for use and on the corresponding staining platform.