normal sexual differentiation
DESCRIPTION
NORMAL SEXUAL DIFFERENTIATION. Suganda Tanuwidjaja. IDENTITAS GENDER. Genotype Gonadale Sex Phenotype Sex Social Gender. GENOTYPE. Chromosomal (Genetic) Sex. Testis-Determining Genes. XY. XX. Ovary-Determining Genes. Gonadale Sex. Gonadale Steroids And Peptidas (T.DHT.AMH). - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/1.jpg)
NORMAL SEXUALNORMAL SEXUALDIFFERENTIATIONDIFFERENTIATION
Suganda Tanuwidjaja
![Page 2: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/2.jpg)
IDENTITAS GENDERIDENTITAS GENDER
1. Genotype
2. Gonadale Sex
3. Phenotype Sex
4. Social Gender
![Page 3: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/3.jpg)
GENOTYPEGENOTYPE
Chromosomal(Genetic) Sex
Gonadale Sex
Ovary-DeterminingGenes
Testis-DeterminingGenes
Phenotypic Sex
Gonadale SteroidsAnd Peptidas
(T.DHT.AMH)(Gonadale Steroids)
XY XX
♂ ♀
![Page 4: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/4.jpg)
• Male : 46 XY
• Female : 46 XX
Y Chromosome (SRY Gene)
Diff. of The Bipotential Gonad
Testis
X Chromosome
One Dose Active
CHROMOSOMAL SEXCHROMOSOMAL SEX
![Page 5: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/5.jpg)
![Page 6: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/6.jpg)
• Gonadal Sex is determined by SRY
• Indiff. Gonad (SRY) Ovary
(+SRY) Testis
GONADAL SEXGONADAL SEX
![Page 7: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/7.jpg)
1 X Chromosome : SRY
Gonad Ovary (Fetal Periode)
Ova Atrophy
(Only 1 Chr)
![Page 8: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/8.jpg)
Cholesterol
STEROID METABOLISM OF GONADSTEROID METABOLISM OF GONAD
Androgen
Estrogen
Enzim
![Page 9: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/9.jpg)
• Internal Ducts
• External Genital Appearance
• Peran Androgen
PHENOTYPE SEXPHENOTYPE SEX
![Page 10: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/10.jpg)
Masculine
Wolffian Ducts
INTERNAL SEX DUCTS BIPOTENTIALINTERNAL SEX DUCTS BIPOTENTIAL
Feminine
Mullerian Ducts
![Page 11: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/11.jpg)
![Page 12: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/12.jpg)
Mullerian Duct Inhibitory Factor (MIF)
TESTICULAR PEPTIDE PRDCTTESTICULAR PEPTIDE PRDCT(SERTOLI CELL)(SERTOLI CELL)
Mullerian Duct Atrophy
Wolffian Duct Developed
![Page 13: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/13.jpg)
MIF
WITHOUT...WITHOUT...
Developed :
• Uterus
• Oviduct
• Upper 2/3 of Vagina
![Page 14: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/14.jpg)
LEYDIG CELL
Testosteron
Wolffian Ducts
• Epididymis• Vas Deferens• Seminal Vesicle
![Page 15: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/15.jpg)
![Page 16: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/16.jpg)
![Page 17: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/17.jpg)
![Page 18: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/18.jpg)
![Page 19: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/19.jpg)
• Bipotential 8 Weeks
• Genital Tubercle Clitoris
• Urogenital Fold Labia Minora
• Labioscrotal Swelling Labia Majora
EXTERNAL GENITALIAEXTERNAL GENITALIA
![Page 20: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/20.jpg)
![Page 21: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/21.jpg)
TestosteroneDihydrotestosterone
(DHT)
5α Reductase Enzyme
Androgen Receptor (ARs)
![Page 22: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/22.jpg)
Genital Tubercle Penis
DHT
ARs
Urogenital Slit Penile Urethra
Labioscrotal Fold Scrotum
![Page 23: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/23.jpg)
Maternal Human Chorionic Gonadotropin(hCG)
11stst TRIMESTER TRIMESTER
Fetal Testes
Testosterone
Male Development
![Page 24: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/24.jpg)
Fetal Pituitary Gonadotropin
22ndnd TRIMESTER TRIMESTER
Testicular Activity
Further Normal Growth
of The Penis
![Page 25: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/25.jpg)
• Gender Development :
1. Gender Identity
2. Gender Role
3. Sexual Orientation
4. Desire & Capacity for Parenting
SOCIAL GENDERSOCIAL GENDER
![Page 26: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/26.jpg)
• Surrounding
• Physical Differentiation
• Interaction
• Prenatal Androgen
DETERMINED FACTORSDETERMINED FACTORS
![Page 27: NORMAL SEXUAL DIFFERENTIATION](https://reader035.vdocuments.site/reader035/viewer/2022062723/56813b6e550346895da475d5/html5/thumbnails/27.jpg)
Thank YouThank You