non conventional using drugs
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Non conventional using drugs. By: Dr Vahedi. Lifestyle drugs. An eclectic group of drugs that are used for non- medical purposes Including : A) Drugs of abuse B) Cosmetic purposes or for purely social reasons C) Enhance athletic or other performance. - PowerPoint PPT PresentationTRANSCRIPT
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Non conventional using drugs
By: Dr Vahedi
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Lifestyle drugs
• An eclectic group of drugs that are used for non- medical purposes
• Including :• A) Drugs of abuse• B) Cosmetic purposes or for purely social reasons• C) Enhance athletic or other performance
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Lifestyle drugs & medicines , excluding drugs in sport
“lifestyle use”
Primary clinical use
Example Category
Erectile enhancment
Erectile dysfunction
sildenafil Medicines approved for specific indication but that can also be used for other lifestyle purposes
Regrowth of hair
HTN minoxidil Medicines approved for specefic indications that can also be used to satisfy “lifestyle choices” or to treat
“lifestyle disease”Cosmetic alteration
Relief of muscle spasm
Botulinum toxin
Drugs have slight or no current clinical use but which fall into the lifestyle category
Recreational usage
Non as such MDMA, Ecstasy
Drugs that have no clinical utility but which are used to satisfy lifestyle requirements
Widespread for many conditions
non Herbal preparation
Natural products,largely unregulated with claim effects but which cater to lifestyle needs or desires
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Enhance athletic or other enhance performance drugs
• 1) Anabolic Agents• 2) Hormones and related substances• 3) β2 –Adrenoceptor agonists• 4) β- Adrenoceptor antagonists• 5) Stimulants• 6) Diuretics• 7) Narcotic analgesics
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Drugs in sport• Anabolic agents Androgenic steroids ( Testosteron, Nandrolone,…) Effects : Increase Muscle development Muscle mass & improve sporting performance↑ Muscle strength ? Increase aggression and competitivness serious long term side effects
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Drugs in sport
• Other Anabolic Agents :Clenbuterol: ( Anabolic androgenic + agonist action on β2 adrenoceptors)
selective androgen receptor modulators (SARMs) : aryl propionamid analogs Bicyclic hydantoein analogs
tibolone ( estrogen activity +weak androgenic activity)
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Drugs in sport Hormones and related substances
EPO : Increased erythrocyte formation & increased oxygen
transport & blood viscosity Side effects: CAD, Strokes (trombos formation) , HTN
Human growth hormone: Effects: ↑lean body mass , ↓fat , accelerate recovery , cardiac
hypertrophy,acromegaly, liver damage, ↑cancer risk
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Drugs in sport Hormones and related substances
• Insulin: To promote glucose uptake and enegy
production in muscle Probably ineffective in improving
performance Side effect: hypoglycemia
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Drugs in sport Hormones and related substances
• Other related substances:
Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH) in male
Corticotrophins
Insulin-like Growth Factor-1 (IGF-1)
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Drugs in sport• β2 –Adrenoceptor agonists (Exp: Salbutamol
formoterol, salmeterol )Used by Runners, swimmers .Mechanism: ↑O2 uptake and transport
(Bronchodilation) cardiac function , Controlled studies show no improvement performance
• β- Adrenoceptor antagonists (Exp: propranolol) used to reduce tremor and anexity in precision sports
(Shooters, ski jumpers, archery)Negative effect on endurance Depression, bronchospasm, fatigue
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Drugs in sport• Stimulants:Ephedrine , methylephenidate, fenfluramine,
cocaein, amiphenazole , strychnine ,taurineEffects: Some trials have shawn ; to improve performance in spriting,
weightlifting. Increase muscle strengh and reduce muscle fatigue Surprisingly Caffeine apears to be more effective in improving
muscle performance than other more powerful stimulants. Several deaths with taking amphetamines &ephedrine – like drugs
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Drugs in sportStimulants:
– AmphetaminesDelay fatigue, increase alertness, enhance
speed, power, endurance, concentrationSide effects: Hypertension, angina, vomiting, abdominal
pain, cerebral hemorrhage, dependence, death
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Drugs in sportStimulants:
– CaffeineShortened reaction time, improved concentration,
diuresis Primary theory is enhanced release of FFA, sparing
glycogen. Stimulate the release of Ca2+ in muscle cells
Glycogen sparing leading to delayed fatigue> 12 ug/mL is a positive urine per IOC
Side effects:Dyspepsia, cardiac damage, combination with other stimulants
(e.g. ephedrine) may be fatal
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Drugs in sportDiuretics: Rapid weight loss also to mask presence of other agent in urine by dilution
– Overall negative impact on performance– Dehydration, hypotension, muscle cramps,
electrolyte imbalance Narcotic, analgesics: used to mask injury- associated pain Increased risk of further injury, dependence,
drowsiness, mental clouding; in high doses: respiratory depression, hypotension
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CONCLUSION
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Mechanism enhance performance drugs
PHYSIOLOGICAL REASONS
Lose weight, train harder
Mask injury and reduce
tiredness
To build muscle,
increase energy
Increase oxygen
transport
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شما توجه سپاساز با
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