Lunasin and Nutritional Epigenetics vs. Conventional

Cancer Drugs"No other company is advancing the field of epigenetics like Reliv. We are in the middle of a revolution in nutrition, and we are all witnesses." Dr. Alfredo Galvez, the Center of Excellence in Nutritional Genomics at University of California - Davis.

Dr. Galvez is working on the development of functional foods and nutraceutical ingredients based on the lunasin peptide, a soy protein component he serendipitously discovered in 1996 as a postdoctoral researcher at UC Berkeley. 

What makes lunasin different from cancer drugs? 

“Cancer drugs, like tamoxifen for example, target a specific gene (ER-estrogen receptor) and a specific physiological pathway (estrogen receptor pathway) in stopping cancer development. Lunasin, as a low potency dietary ingredient, has been shown in a number of publications to affect multiple genes in multiple pathways, albeit in incremental fashion, to help prevent cancer development.” Dr. Galvez

View how lunasin affects multiple genes in multiple pathways

Conventional Drug Development

From Hanahan and Weinberg, 2000 Cell 100:50-57

Conventional Drug Development

From Hanahan and Weinberg, 2000 Cell 100:50-57

PP2

PI3K

Conventional Drug Development

From Hanahan and Weinberg, 2000 Cell 100:50-57

PP2

PI3KX

Conventional Drug Development

From Hanahan and Weinberg, 2000 Cell 100:50-57

PP2

PI3K

chloroquine

X

Conventional Drug Development

From Hanahan and Weinberg, 2000 Cell 100:50-57

Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways

Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways

Akt

Bcl2

Bcl2

Ras

Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways

Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways

α5β3

NF-κB

Lunasin inhibits oncogene and carcinogen-induced cell transformation.

p53

Akt

Bcl2

Bcl2caspase

Bad

Ras

Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways

Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways

Rbα5β3

NF-κB

p21

Pten

Lunasin inhibits oncogene and carcinogen-induced cell transformation.

Lunasin increases expression of genes associated with tumor suppression, apoptosis, mitotic control and DNA repair.

pp32

p53

Akt

Bcl2

Bcl2caspase

Bad

Ras

Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways

Lunasin as a dietary ingredient prevents disease formation by affecting multiple pathways

Rbα5β3

NF-κB

p21

Pten

Lunasin inhibits oncogene and carcinogen-induced cell transformation.

Lunasin increases expression of genes associated with tumor suppression, apoptosis, mitotic control and DNA repair.

pp32

Tamoxifen chemopreventive drug inhibits estrogen receptor (ER)

ER

1) Prevents cancer formation induced by chemical carcinogens

2) Prevents cancer formation induced by viral oncogenes3) Prevents cancer formation caused by inactivation of

tumor suppressors.4) Inhibits inflammation5) Improves innate immunity or ability to fight infections6) Enhances anti-oxidant effects in cells 7) Prevents metastasis of colon cancer cells to the liver8) Has functional and structural similarity to a human tumor

suppressor9) Increases expression of liver enzyme that detoxifies

carcinogen that can cause prostate cancer

Anti-cancer Properties of Lunasin (published and current research)

Lunasin’s epigenetic mechanism of action

Chromosome

Chromatin

Methyl group

DNA methylation

HISTONE TAILGENE

HISTONEHistones are proteins around which DNA is packaged. Modification of histone tails are important in gene regulation

Methyl group can tag DNA at CpG dinucleotide and is associated with gene repression

Compacted chromatin – DNA inaccesible – gene inactive

Histone tail modifiers (HAT/HDAC)

PCAFSirT1P300/CBP

HISTONE ACETYLATION

Unwound chromatin – DNA accessible – gene active

GENE

Gene Expression On

Lunasin’s epigenetic mechanism of action

Chromosome

Chromatin

Methyl group

DNA methylation

HISTONE TAILGENE

HISTONEHistones are proteins around which DNA is packaged. Modification of histone tails are important in gene regulation

Methyl group can tag DNA at CpG dinucleotide and is associated with gene repression

Compacted chromatin – DNA inaccesible – gene inactive

Histone tail modifiers (HAT/HDAC)

PCAFSirT1P300/CBP

HISTONE ACETYLATION

Unwound chromatin – DNA accessible – gene active

GENE

Lunasin

Gene Expression On

Lunasin’s epigenetic mechanism of action

Chromosome

Chromatin

Methyl group

DNA methylation

HISTONE TAILGENE

HISTONEHistones are proteins around which DNA is packaged. Modification of histone tails are important in gene regulation

Methyl group can tag DNA at CpG dinucleotide and is associated with gene repression

Compacted chromatin – DNA inaccesible – gene inactive

Histone tail modifiers (HAT/HDAC)

PCAFSirT1P300/CBP

HISTONE ACETYLATION

Unwound chromatin – DNA accessible – gene active

GENE

Lunasin

Gene Expression Off

0

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80

100

120

140

160

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1.00 2.66 6.01

204

Fold

Incr

ease

Industry Standard

Soy Protein Isolate

LunaRich™ Soy Powder

LunaRich X™

Lunasin bioactivity of soy protein formulations

LunaRich: Nutrition at a Higher Level

What is it? Reliv's exclusive non-GMO LunaRich® delivers five to ten times the amount of lunasin, a naturally occurring peptide that provides many of soy's documented health benefits. Numerous studies demonstrate lunasin’s superior support for cancer-preventive effects, cardiovascular health, significant anti-inflammatory properties, anti-aging, and skin health. 

LunaRich products are quite simply the most advanced soy formulations on the market today —  Take control of your health!

Order Today: WealthThruNutrition.com