New York University Department of Radiation Oncology

Prospective Randomized Trial of Prone Accelerated Intensity Modulated Whole Breast Radiation Therapy with a Daily Versus

Weekly Boost to the Tumor Bed: 3-Year Results

B.T. Cooper1, G.F. Formenti-Ujlaki1, S.M. Shin1, M. Fenton-Kerimian1, D. Roses2, A.

Guth2, G. Jozsef1, J.K. Dewyngaert1 and S.C. Formenti 1

1Department of Radiation Oncology, 2Department of Surgery, New York University School of Medicine and Langone Medical Center, New York, New York

New York University Department of Radiation Oncology

• 400 pts• Cosmesis data

available in 70% of patients

• Median f/u 40 months• Provider and patient

reported cosmesis were recorded based on the LENT/SOMA criteria.

New York University Department of Radiation Oncology

More patients reporting good or excellent cosmesis in Arm 2 that approached significance (80% vs 88%; p = 0.08)

P = 0.08 P = 0.25

New York University Department of Radiation Oncology

There was no statistical difference in 3 year recurrence free survival between the two arms (98% vs 97%; log-rank p = 0.7)

• One local and two distant recurrences in Arm 1

• Three local and one distant recurrences in Arm 2

P = 0.7