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Curriculum Vitae Europass

Informazioni personali

Cognome(i) / Nome(i) MECOCCI PATRIZIA

E-mail [email protected]

Codice Fiscale MCCPRZ61C57L117P

Esperienza professionale

Date 2011

Principali attività e responsabilità Presidente del Corso di Laurea in Logopedia, Scuola Interdipartimentale di Medicina e Chirurgia

Nome e indirizzo del datore di lavoro Università di Perugia (Italia)

DateDate 2009 →

Principali attività e responsabilitàPrincipali attività e

responsabilità

Direttore, Dipartimento di Geriatria

Nome e indirizzo del datore di lavoroNome e indirizzo del datore di

lavoro

Ospedale Universitario S. M.aria della Misericordia Perugia (Italia)

Date 2009 →

Principali attività e responsabilità Direttore, Scuola di Specializzazione in Geriatria


Date 2006 →

Principali attività e responsabilità Professore Ordinario, Istituto di Gerontologia and Geriatria


Date 2001 - 2006

Principali attività e responsabilità Professore Associato, Istituto di Gerontologia and Geriatria


Date 1997 - 2001

Principali attività e responsabilità Ricercatorerice, Istituto di Gerontologia e Geriatria


Date 10/2002 - 08/2003

Principali attività e responsabilità Visiting Professor ARC-(Prof. Laura Fratiglioni, Prof. Bengt Winblad)

Nome e indirizzo del datore di lavoro Karolinska Institutet Stockholm (Sweden)

Date 01/1992 - 07/1998

Principali attività e responsabilità Ricercatrice, Dipartimento di Neurologia, (Prof. M. Flint Beal)

Nome e indirizzo del datore di lavoro Massachusetts General Hospital-Harvard Medical School Boston (USA)

Date 12/1988 - 06/1991

Principali attività e responsabilità Ricercatrice, Dipartimento of Psichiatria e Neurochimica (Prof. Rolf Ekman)

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Nome e indirizzo del datore di lavoro University of Lund (Svezia)

Istruzione e formazione

Date 1996 →

Titolo della qualifica rilasciata Specializzazione in Geriatria

Nome e tipo d'organizzazione erogatrice dell'istruzione e formazione

Università di Perugia (Italia)

Date 1992 →

Titolo della qualifica rilasciata Dottorato di ricerca ( PhD)

Principali tematiche/competenze professionali acquisite

Biologia e fisiopatologia dell’invecchiamento


Università di Modena (Italia)

Date 1987 →

Titolo della qualifica rilasciata Laurea

Principali tematiche/competenze professionali acquisite

Medicina e chirurgia


Università di Perugia (Italia)

Capacità e competenze personali

Ulteriori informazioni Altre Esperienze e Partecipazioni Professionali

1995-2000 responsabile gruppo di studio sull’invecchiamento cerebrale della Società Italiana di Gerontologia e Geriatria

2000- 2008 responsabile del “Network Geriatrico Italiano sulla Malattia di Alzheimer” della Società Italiana di Gerontologia e Geriatria

2006- a oggi : Membro del “ European Alzheimer Disease Consortium (EADC)” e membro della Steering Committee EDC (2010-2013)

2009-2012a oggi Membro del “Scientific Advisory Panel on Dementia of the European College of Neuropsychopharmacology (ECNP)”

2006–2010 Presidente regionale Umbria-Marche della Associazione Italiana di Psicogeriatria (AIP)

2010-2011 Presidente della Società Italiana of Neurogeriatria (SiNeG) 2009-2014 Presidente Sezione Umbria Società Italiana di Geriatria (SIGG) 2012-2014 Tesoriere Nazionale SIGG

Onorificenze

1987 Premio di laurea della Associazione Medica di Terni.

1987 Premio di laurea della TOE Foundation, Terni.

1988-1990 Borsa di studio della Commissione Episcopale Italiana (CEI) per giovani ricercatori

1989 Premio Società Italiana di Gerontologia e Geriatria per giovani ricercatori

1991 Premio ISGBA (Italian Study Group on Brain Aging)

1992 Finanziamento da parte del CNR per il “Project on Aging”

Allegati AB. Pubblicazioni su riviste indicizzate (in ordine cronologico) (selezionate su 145 rilevabili in PubMed)

1. 1Parnetti L., Mecocci P., Petrini A., Longo A., Buccolieri A., Senin U. Neuropsychological

results of long-term therapy with oxiracetam in DAT/MID patients in comparison with a

Formattato: CV Normal

Formattato: Tipo di carattere: Grassetto

Formattato: Inglese (Stati Uniti)

Formattato: SpazioDopo: 3 pt

Formattato: Tipo di carattere: Arial Narrow



control group. Neuropsychobiology 22: 97-100, 1989.

2. Parnetti L., Mecocci P., Ciuffetti. G., Bellomo G., Senin U. Blood pressure and functional aspects of the aging brain. Arch Geront Geriatr 9: 155-161, 1989.

3. Parnetti L., Mecocci P., Gaiti A., Cadini D., Lombardi F., Visconti L., Senin U. Comparative kinetics of oxiracetam in serum and CSF of patients with dementia of Alzheimer type. Eur J Drug Metab Pharmacol 15: 75-78, 1990.Parnetti L., Mecocci P., Santucci C., Gaiti A., Petrini A., Longo A., Cadini D., Caputo N., Signorini E., Senin U. Is multi-infarct dementia representative of vascular dementias? A retrospective study. Acta Neurol Scand 81: 484-487, 1990.

4. Parnetti L., Mecocci P., Neri C., Palazzetti D.‚ Fiacconi M., Santucci A., Santucci C., Ballatori E., Reboldi G.P., Caputo N., Signorini E., Senin U. Neuroendocrine markers in aging brain: clinical and neurobiological significance of dexamethasone suppression test. Aging Clin Exp Res 2: 173-179, 1990.

5. Mecocci P., Parnetti L., Reboldi G.P., Santucci C., Gaiti A., Ferri C., Gernini I., Romagnoli M., Cadini D., Senin U. Blood-brain-barrier in a geriatric population: barrier function in degenerative and vascular dementias. Acta Neurol. Scand. 84: 210-213, 1991.

6. Parnetti L., Gaiti A., Mecocci P., Cadini D., Senin U. Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type. Eur. J. Clin. Pharmacol. 42: 89-93, 1992.

7. Parnetti L., Gaiti A., Reboldi G.P., Santucci C., Mecocci P., Brunetti M., Cadini D., Senin U. CSF monoamine metabolites in old age dementias. Mol Chem Neuropathol (oggi J Mol Neurosci), 16: 143-157, 1992.

8. Parnetti L., Mecocci P., Reboldi G.P., Santucci C., Brunetti M., Gaiti A., Cadini D., Senin U. Platelet MAO-B activity and vitamin B12 in old age dementias. Mol Chem Neuropathol 16: 23-32, 1992.

9. Mecocci P., Parnetti L., Donato R., Santucci C., Santucci A., Cadini D., Foà E., Cecchetti R., Senin U. Serum autoantibodies against glial fibrillary acidic protein in brain aging and senile dementias. Brain Behav Immunity 6: 286-292, 1992.

10. Mecocci P., Ekman R., Parnetti L., Senin U. Antihistone and anti-dsDNA autoantibodies in Alzheimer's disease and vascular dementia. Biol Psychiatry 33: 380-385, 1993.

11. Mecocci P., MacGarvey U., Kaufman A.E., Koontz D., Shoffner J.M., Wallace D.C., Beal M.F. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol 34: 609-616, 1993.

12. Parnetti L., Mari D., Mecocci P., Senin U. Pathogenetic mechanisms in vascular dementia. Int. J. Clin. Lab. Res. 24: 15-22, 1994.

13. Mecocci P., MacGarvey U., Beal M.F. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol 36: 747-751, 1994.

14. Mecocci P., Parnetti L., Romano G., Scarelli A., Cecchetti R., Polidori M.C., Palumbo B.,Chionne F., Cherubini A., Senin U. Serum anti-GFAP and anti-S100 autoantibodies in brain aging, Alzheimer's disease and vascular dementia. J. Neuroimmunol 57: 165-170, 1995.

15. Schulz J., Matthews R.T., Jenkins B.G., Ferrante R.J., Siwek D., Henshaw D.R., Cipolloni P.B., Mecocci P., Kowall N.W., Rosen B.R., Beal M.F. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo. J Neurosci 15: 8419-8429, 1995.

16. Mecocci P., Cherubini A., Beal M.F., Cecchetti R., Chionne F., Polidori M.C., Romano G., Senin U. Altered mitochondrial membrane fluidity in AD brain. Neurosci Lett 207: 129-132; 1996.

17. Cherubini A., Mecocci P., Senin U., Lowenthal D.T., Barnert G., Chionne F. Autoantibodies against oxidized low-density lipoproteins in older stroke patients. J. Am. Geriatr. Soc. 45:125; 1997.

18. Mecocci P., Cherubini A., Polidori M.C., Cecchetti R., Chionne F., Senin U. Oxidative stress and dementia: new perspectives in AD pathogenesis. Aging 9 (4 Suppl):51-52; 1997.

19. Parnetti L., Senin U., Mecocci P. Cognitive enhancement therapy: the way forward. Drugs 53: 752-768, 1997.

20. Senin U., Cherubini A., Palumbo B., Mecocci P. Pharmaceutical treatment of cognitive disorders in Alzheimer's disease. Funct Neurol 12: 211-212; 1997.

21. Mecocci P., Beal M.F., Cecchetti R., Polidori M.C., Cherubini A., Chionne F., Avellini L., Romano G., Senin U. Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain. Mol Chem Neuropathol 31: 53-64; 1997.

22. Mecocci P., Cherubini A., Senin U. Increased oxidative damage in lymphocytes of Alzheimer disease patients. (Letter) J. Am. Geriatr. Soc. 45, 1536-1537, 1997

Formattato: Tipo di carattere: Arial Narrow, Italiano (Italia)


Formattato: Tipo di carattere: Arial Narrow, Inglese (RegnoUnito)


Formattato: Tipo di carattere: Arial Narrow, Inglese (RegnoUnito)









23. Cherubini A., Lowenthal D.T., Williams L.S., Maggio D., Mecocci P., Senin U. Physical activity and cardiovascular health in the elderly. Aging Clin. Exp. Res. 10: 13-25; 1998.

24. Polidori M.C., Frei B., Cherubini A., Nelles G., Rurdorf G., Keaney J.F., Schwamm L., Mecocci P., Koroshetz W.J., Beal F.M. Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke. Free Rad Biol Med 25: 561-567; 1998.

25. Mecocci P., Cherubini A., Bregocchi M., Chionne F., Cecchetti R., Lowenthal D.T., Senin U. Tau protein in cerebrospinal fluid: a new diagnostic and prognostic marker in Alzheimer disease? Alz Dis Assoc Disord 12: 211-214;1998.

26. Mecocci P., Polidori M.C., Ingegni T., Cherubini A., Chionne F., Cecchetti R., Senin U. Oxidative damage to DNA in lymphocytes from AD patients. Neurology 51: 1014-1017;1998.

27. Cherubini A., Donahue J.L., Lowenthal D.T., Mecocci P., Meuleman J.R., Maggio D., Senin U. The effects of aging and endurance exercise on cardiovascular performance in healthy elderly: a review of the literature. Am J Geriatr Cardiol 7: 25-32, 1998.

28. Mecocci P., Cherubini A., Polidori M.C., Cecchetti R., Chionne F., Senin U. Oxidative stress and lymphocytes in Alzheimer disease. Arch Gerontol Geriatr 26 (suppl 1) 313-316, 1998.

29. Mecocci P., Fanò G., Fulle S., MacGarvey U., Shinobu L., Polidori M.C., Cherubini A., Vecchiet J., Senin U., Beal F.M. Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Rad Biol Med 26:303-308;1999.

30. Lezza A.M.S., Mecocci P., Cormio A., Cherubini A., Beal M.F., Cantatore P., Senin U., Gadaleta

M.G. Mitochondrial 4977 bp deletion and OH8dG correlate in the brain of aged subjects but not in Alzheimer's disease patients. FASEB J 13: 1083-1088, 1999.

31. Polidori M.C., Mecocci P., Briviba K., Reimann A., Cecchetti R., Stahl W., Sies H., Senin U. Plasma lipid peroxidation and vitamin C status in healthy centenarians (Letter). J Am Geriat Soc 47: 1038-1039, 1999.

32. Polidori M.C., Mecocci P., Browne S., Senin U., Beal M.F. Oxidative damage to mitochondrial DNA in Huntington’s disease parietal cortex. Neurosci Lett 272: 53-56, 1999.

33. Brandi M.L. Becherini L., Gennari L., Racchi R., Bianchetti A., Nacmias B., Sorbi S., Mecocci P., Senin U., Govoni S. Association of the oestrogen receptor alpha gene polymorphism with sporadic Alzheimer's disease. Biochem Biophys Res Comm 265: 335-338, 1999.

34. Pippi M., Mecocci P., Saxton J., Bartorelli L., Pettenati C., Bonaiuto S., Cucinotta D., Masaraki G., Neri M., Tammaro A.E., Vergani C., Chionne F., Senin U and Gruppo di Studio sull’Invecchiamento Cerebrale della Società Italiana di Gerontologia e Geriatria: Neuropsychological assessement of the severely impaired elderly patient: validation of the Italian short version of the Severe Impairment Battery (SIB). Aging Clin Exp Res 4: 221-226, 1999.

35. Polidori M.C., Mecocci P., Stahl W., Parente B., Cecchetti R., Cherubini A., Cao P., Sies H., Senin U. Plasma levels of lipophilic antioxidants in very old subjects with non insulin-dependent diabetes. Diabetes Metab Res Rev 16: 15-19, 2000.

36. Polidori M.C., Mecocci P., Cherubini A., Senin U. Physical activity and oxidative stress during ageing. Int J Sports Med 21: 1-4, 2000.

37. Mecocci P.,Polidori M.C., Troiano L., Cherubini A., Cecchetti R., Straatmann M., Monti D., Stahl W., Sies H., Franceschi C., Senin U. Plasma antioxidants and longevity: a study on healthy centenarians. Free Rad Biol Med, 28: 1243-1248; 2000.

38. Cherubini A., Polidori M.C. , Bregnocchi M., Pezzuto S., Cecchetti R., Ingegni T., Di Iorio A:, Senin U., Mecocci P. Antioxidant profile and early outcome in stroke patients. Stroke 31: 2295-2300, 2000.

39. Mecocci P., Di Iorio A., Pezzuto S., Rinaldi P., Simonelli G., Maggio D:, Montesperelli P., Longo A., Cherubini A., Chiarappa N., Abate G., Senin U. Impact of the earthquake of September 26, 1997 in Umbria, Italy, on the socioenvironmental and psychophysical conditions of an elderly population. Aging Clin Exp Res 12: 281-286; 2000.

40. Fulle S., Mecocci P., Fanò G., Vecchiet I., Vecchini A., Racciotti D., Cherubini A., Pizzigallo E., Vecchiet L., Senin U., Beal M.F. Specific oxidative alterations in vastus lateralis muscle of patients with diagnosis of Chronic Fatigue Syndrome. Free Rad Biol Med 29: 1252-1259, 2000.

41. Zuliani G., Volpato S., Mecocci P., Cherubini A. The A677V MTHFR allele is not associated with carotid atherosclerosis in octogenarians. Stroke 31: 990-991;2000.

42. Polidori M.C., Cherubini A., Senin U., Mecocci P. Hyperhomocysteinemia and oxidative stress in ischemic stroke. Stroke 32: 275-278;2001.











43. Ekman R., Gobom J., Persson R., Mecocci P., Nilsson C. Arginine vasopressin in the cytoplasm and nuclear fraction of lymphocytes from healthy donors and patients with depression or schizophrenia. Peptides 22: 67-72, 2001.

44. Polidori M.C., Mecocci P., Frei B. Plasma vitamin C levels are decreased and correlated with brain damage in patients with intracranial hemorrhage or head trauma. Stroke 32: 898-902, 2001.

45. Polidori M.C., Pelliccioli G.P., Catani M., Finali G., Senin U. Mecocci P., Superficial siderosis of the central nervous system: a 70-year-old man with ataxia, depression and visual deficits. Gerontology 47: 93-95, 2001.

46. Cherubini A., Zuliani G., Costantini F., Pierdomenico S.D., Mezzetti A., Mecocci P., Volpato S., Pezzuto S., Bregnocchi M., Fellin R., Senin U. and the VaSA study group. High vitamin E plasma levels and low Low-density lipoprotein oxidation are associated with the absence of atherosclerosis in octogenarians. J Am Geriat Soc 49: 651-654, 2001.

47. Catani M., Cherubini A., Tarducci R., Senin U., Mecocci P. The brain of the elderly between normality and pathology: techniques and technologies for the evaluation. Arch Gerontol Geriatr 33 Suppl 1: 77-80, 2001.

48. Polidori M.C., Marvardi M., Cherubini A., Senin U., Mecocci P. Heart disease and vascular risk factors in the cognitively impaired elderly: implications for Alzheimer's dementia. Aging Clin Exp Res 13:231-239;2001.

49. Catani M., Cherubini A., Tarducci R., Pelliccioli G., Piccirilli M., Gobbi G., Senin U., Mecocci P. 1H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging. Neuroreport, 12:2315-7, 2001.

50. Polidori M.C., Cherubini A., Senin U., Mecocci P. Peripheral non-enzymatic antioxidant changes with human aging: a selective status report. (Review). Biogerontology 2: 99-104, 2001.

51. Fanò G., Mecocci P., Vecchiet J., Belia S., Fulle S., Polidori M.C., Felzani G., Senin U., Vecchiet L., Beal M.F. Age and sex influence on oxidative damage and functional modifications in human skeletal muscle. J Muscle Res Cell Motility 22: 345-351; 2001.

52. Polidori M.C., Menculini G., Senin U., Mecocci P. Dementia, depression and parkinsonism: A frequent association in the elderly. J Alzheimers Dis 3: 553-562, 2001

53. Polidori M.C., Savino K., Alunni G., Freddio M., Senin U., Sies H., Stahl W., Mecocci P. Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure patients: relationship to disease severity. Free Radic Biol Med 32: 148-152; 2002.

54. Mecocci P., Polidori M.C., Cherubini A, Ingegni T., Mattioli P., Catani M., Rinaldi P., Cecchetti R., Stahl W., Senin U., Beal M.F. Lymphocytes oxidative DNA damage and plasma antioxidants in normal aged people and and Alzheimer disease patients. Arch Neurol 59: 794-798, 2002.

55. Ceresini G., Rebecchi I., Morganti S., Maggio M., Solerte S.B., Corcione L., Izzo S., Mecocci P., Valenti G. Effects of vitamin A administration on serum thyrotropin concentrations in healthy human subjects. Metabolism 51: 691-694, 2002.

56. Polidori M.C., Cherubini A., Stahl W., Senin U., Sies H., Mecocci P. Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome. Free Radic Res 36: 265-268, 2002.

57. Zuliani G., Cherubini A., Palmieri E., Volpato S., Mecocci P., De Rango P., Cao P.G., Senin U., Fellin R. Genetic factors associated with the absence of atherosclerosis in octogenarians. J Gerontol 57: M611-615, 2002.

58. Catani M., Mecocci P., Tarducci R., Howard R., Pelliccioli G.P., Mariani E., Metastasio A. Benedetti C. Senin U. Cherubini A. Proton magnetic resonance spectroscopy reveals similar white matter biochemical changes in patients with chronic hypertension and early Alzheimer's disease. J Am Geriatr Soc 50:1707-1710, 2002.

59. Mecocci P., Grossi E., Buscema M., Intraligi M., Savaré R. Cherubini A., Rinaldi P., Senin U. Use of artificial neural networks in clinical trials: a pilot study to predict the responsiveness to donepezil in Alzheimer disease patients. J Am Geriatr Soc 50: 1857-1860, 2002.

60. Polidori M.C., Mecocci P. Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease. J Alzheimers Dis 4: 517-522, 2002.

61. Catani M., Piccirilli M., Cherubini A., Tarducci R., Sciarma T., Gobbi G., Pelliccioli G.P., Petrillo S.M., Senin U., Mecocci P. Axonal injury within language network in primary progressive aphasia: a 1H-MR spectroscopy study. Ann Neurol 53: 242-247, 2003.

62. Maggio D., Barabani M., Pierandrei M., Polidori M.C., Catani M., Mecocci P., Senin U., Pacifici R., Cherubini A. Marked decrease in plasma antioxidants in aged osteoporotic women:



results of a cross-sectional study. J Clin Endocr Metab 88: 1523-1527, 2003.

63. Senin U, Cherubini A, Mecocci P. Impact of population aging on the social and the health care system: need for a new model of long-term care. Ann Ital Med Int 18: 6-15, 2003.

64. Rinaldi P., Mecocci P., Benedetti C., Ercolani S., Bregnocchi M., Menculini G., Catani M., Senin U., Cherubini A. Validation of the five-item Geriatric Depression Scale in elderly subjects in three different settings. J Am Geriatr Soc 51: 694-598, 2003.

65. Ingegni T., Nocentini G., Mariani E., Spazzafumo L., Polidori M.C., Cherubini A., Catani M., Cadini D., Senin U., Mecocci P. Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer’s disease. Dement Geriatr Cogn Disord 16: 151-155, 2003.

66. Polidori M.C., Mecocci P., Stahl W., Sies H. Cigarette smoking cessation increases plasma levels of several antioxidant micronutrients and improves resistance towards oxidative challenge. Br J Nutr 90: 147-150, 2003.

67. Rinaldi P., Polidori M.C., Metastasio A., Mariani E., Mattioli P., Cherubini A., Catani M., Cecchetti R., Senin U., Mecocci P. Plasma antioxidants are similarly depleted in Mild Cognitive Impairment and in Alzheimer disease. Neurobiol Aging 24: 915-919, 2003.

68. Trojano L., Antonelli Incalzi R., Acanfora D., Picone C., Mecocci P., Rengo F.; Congestive Heart Failure Italian Study Investigators. Cognitive impairment: a key feature of congestive heart failure in the elderly. J Neurol 250: 1456-1463, 2003.

69. Hugonot-Diener L., Verny M., Devouche E., Saxton J., Mecocci P., Boller F. Abridged version of the severe impairment battery (SIB). Psychol Neuropsychiatr Vieil 1: 273-283, 2003.

70. Catani M., Piccirilli M., Geloso M.C., Cherubini A., Finali G., Pelliccioli G.P., Senin U., Mecocci P. Rapidly progressive aphasic dementia with motor neuron disease: a distinctive clinical entity. Dement Geriatr Cogn Disord 17: 21-28, 2004.

71. Polidori M.C., Mecocci P., Levine M., Frei B. Short-term and long-term vitamin C supplementation in humans dose-dependently increases the resistance of plasma to ex-vivo lipid peroxidation. Arch Biochem Biophys 423: 109-115, 2004.

72. Mecocci P. Oxidative stress in mild cognitive impairment and Alzheimer disease: A continuum. J Alzheimers Dis 6: 159-163, 2004.

73. Mecocci P., Mariani E., Cornacchiola V., Polidori M.C. Antioxidants for the treatment of mild cognitive impairment. Neurol Res 26: 598-602, 2004.

74. Polidori M.C., Mattioli P., Aldred S., Cecchetti R., Stahl W., Griffiths H., Senin U., Sies H., Mecocci P. Plasma antioxidant status, immunoglobulin G oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia. Dement Geriatr Cogn Disord 18: 265-270, 2004.

75. Polidori M.C., Praticò D., Savino K., Rokach J., Stahl W., Mecocci P. Increased F2 isoprostane plasma levels in patients with congestive heart failure are correlated with antioxidant status and disease severity. J Cardiac Failure 10: 334-338, 2004

76. Mecocci P., Cherubini A., Mariani E., Ruggiero C., Senin U. Depression in the elderly: new concepts and therapeutic approaches. Aging Clin Exp Res 16: 176-189, 2004

77. Scafato, E., Gandin, C., Farchi, G. Abete P., Baldereschi M., Di Carlo A., Inzitari D, Maggi S., Panza F., Solfrizzi V, (I.PR.E.A. Working Group - Italian PRoject on Epidemiology of Alzheimer’s disease). Italian Project on Epidemiology of Alzheimer’s disease (I.PR.E.A.): study design and methodology of cross-sectional survey. Aging Clin Exp Res 17: 29-34, 2005

78. Rinaldi P., Spazzafumo L., Mastriforti R., Mattioli P., Marvardi M., Polidori M.C., Abate G., Bartorelli L., Bonaiuto S., Capurso A., Cucinotta D., Gallucci M., Giordano M., Martorelli M., Masaraki G., Tammaro V.A., Nieddu A., Pettenati C., Putzu P., Tomassini P.F., Vergani C., Senin U., Mecocci P., and the GSIC-SIGG. Predictors of high level of burden and distress in caregivers of demented patients: results of an Italian multicenter study. Int J Geriatr Psychiatry 20: 168-174, 2005.

79. Cherubini A., Martin A., Andres-Lacueva C., Di Iorio A, Lamponi M., Mecocci P., Bartali B., Corsi A., Senin U., Ferrucci L. Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study. Neurobiol Aging 26: 987-994, 2005.

80. Marvardi M., Mattioli P., Spazzafumo L., Mastriforti R., Rinaldi P., Polidori M.C., Cherubini A., Quartesan R., Bartorelli L., Bonaiuto S., Cucinotta D., Di Iorio A., Gallucci M., Giordano M., Martorelli M., Masaraki G., Tammaro E.., Nieddu A., Pettenati C., Putzu P., Solfrizzi V., Tomassini P.F., Vergani C., Senin U., Mecocci P., and the GSIC-SIGG. The Caregiver Burden Inventory in evaluating the burden of caregivers of elderly demented patients: results from a multicenter study. Aging Clin Exp Res 17: 46-53, 2005.

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Formattato: Tipo di carattere: Arial Narrow, Colore carattere:Automatico

Formattato: Tipo di carattere: Arial Narrow, Colore carattere:Automatico, Italiano (Italia)






81. Mecocci P., vonStrauss E., Cherubini A., Ercolani S., Mariani E., Senin U., Winblad B., Fratiglioni L. Cognitive impairment is the major risk factor for development of geriatric syndromes during hospitalization: results from the GIFA Study. Dement Geriatr Cogn Disord 20: 262-269, 2005.

82. Cherubini A., Ruggiero C., Polidori M.C., Mecocci P. Potential markers of oxidative stress in stroke. Free Radic Biol Med 39: 841-852, 2005.

83. Mariani E., Polidori M.C., Cherubini A., Mecocci P. Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromat B 827: 65-75, 2005.

84. Anlasik T., Sies H., Griffiths H.R., Mecocci P., Stahl W., Polidori M.C. Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects. Br J Nutr 94: 639-642, 2005.

85. Saxton J., Kastango K.B., Hugonot-Diener L., Boller F., Verny M., Sarles C.E., Girgis R.R., Devouche E., Mecocci P., Pollock B.G., DeKosky S.T. Development of a short form of the Severe Impairment Battery. Am J Geriatr Psychiatry 13: 999-1005, 2005.

86. Polidori M.C., Praticó D., Ingegni T., Mariani E., Spazzafumo L., Del Sindaco P., Cecchetti R., Yao Y., Ricci S., Cherubini A., Stahl W., Sies H., Senin U., Mecocci P. for the AVASAS Study Group. Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study. BioFactors 24: 265-274, 2005.

87. Pedone C., Ercolani S., Catani M., Maggio D., Ruggiero C., Quartesan R., Senin U., Mecocci P., Cherubini A. Elderly patients with cognitive impairment have a high risk for functional decline during hospitalization: the GIFA study. J Gerontol 60: 1576-1580, 2005.

88. Caltagirone C., Bianchetti A., Di Luca M., Mecocci P., Padovani A., Pirfo E., Scapicchio P., Senin U, Trabucchi M, Musicco M; Italian Association of Psychogeriatrics. Guidelines for the treatment of Alzheimer's disease from the Italian Association of Psychogeriatrics. Drugs Aging 22 (Suppl 1): 1-26, 2005.

89. Metastasio A., Rinaldi P., Tarducci R., Mariani E., Feliziani F.T., Cherubini A., Pelliccioli G.P., Gobbi G., Senin U., Mecocci P. Conversion of MCI to dementia: role of proton magnetic resonance spectroscopy. Neurobiol Aging 27: 926-932, 2006.

90. Monastero R., Mariani E., Camarda C., Ingegni T., Averna M., Senin U., Camarda R., Mecocci P. Association between the apolipoprotein E 4 allele and apathy in probable Alzheimer´s disease. Acta Psych Scand 113: 59-63, 2006.

91. Mariani E., Seripa D., Ingegni T., Nocentini G., Mangialasche F., Ercolani S., Cherubini A., Metastasio A., Pilotto A., Senin U., Mecocci P. Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer’s disease. J Neurol Sci 247:187-191, 2006.

92. Polidori MC, Mariani E, Mecocci P, Nelles G. Congestive heart failure and Alzheimer's disease. Neurol Res 28:588-594, 2006.

93. Mariani E., Cornacchiola V., Polidori M.C., Mangialasche F., Malavolta M., Cecchetti R., Bastiani P., Baglioni M., Mocchegiani E., Mecocci P. Antioxidant enzyme activities in healthy old subjects: influence of age, gender and zinc status. Results from the Zincage Project. Biogerontology 7: 391-398, 2006.

94. Polidori M.C,. Mariani E., Baggio G., Deiana L., Carru C., Pes G.M., Cecchetti R., Franceschi C., Senin U., Mecocci P. Different antioxidant profiles in Italian centenarians: the Sardinian peculiarity. Eur J Clin Nutr 61: 922-924, 2007.

95. Polidori MC, Griffiths HR, Mariani E, Mecocci P. Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease. Amino Acids 32: 553-559, 2007.

96. Galli F., Polidori M.C., Stahl W., Mecocci P., Kelly F.J. Vitamin e biotransformation in humans. Vitam Horm 76:263-280, 2007.

97. Polidori M.C., Praticó D., Parente B., Mariani E., Cecchetti R., Yao Y., Sies H., Cao P., Mecocci P., Stahl W. Elevated lipid peroxidation biomarkers and low antioxidant status in atherosclerotic patients with increased carotid and iliofemoral intima-media thickness. J Inv Med 55: 163-167, 2007.

98. Mariani E., Monastero R., Mecocci P. Mild Cognitive Impairment: a systematic review. J Alzheimers Dis 12: 23-35, 2007.

99. Mariani E., Monastero R., Ercolani S., Caputo M., Mangialasche F., Feliziani F.T., Vitale D.F., Senin U., Mecocci P. for the ReGAl Study Group. Vascular risk factors in Mild Cognitive Impairment subtypes. Findings from the ReGAl project. Dement Geriatr Cogn Disord 24: 448-456, 2007.







100. Cherubini A., Lowenthal D.T., Paran E., Mecocci P., Williams L.S., Senin U. Hypertension and Cognitive Function in the Elderly. Am J Ther14: 533-554, 2007.

101. Aalten P., Verhey F.R.J., Boziki M., Bullock R., Byrne E.J., Camus V., Caputo M., Collins D., De Deyn P.P., Elina K., Girtler N., Holmes C., Hurt C., Marriott A., Mecocci P., Nobili F., Ousset P.J., Frisoni G.B., Salmon E., Tsolaki M., Vellas B., Robert P.H. Neuropsychiatric syndromes in dementia. Results from the European Alzheimer Disease Consortium (EADC): Part I. Dement Geriatr Cogn Disord 24: 457-463, 2007.

102. Aalten P., Verhey F.R., Boziki M., Brugnolo A., Bullock R., Byrne E.J., Camus V., Caputo M., Collins D., De Deyn P.P., Elina K, Frisoni G, Holmes C, Hurt C, Marriott A, Mecocci P., Nobili F., Ousset P.J., Reynish E., Salmon E., Tsolaki M., Vellas B., Robert P.H. Consistency of neuropsychiatric syndromes across dementias: results from the European Alzheimer Disease Consortium. Part II. Dement Geriatr Cogn Disord 25: 1-8, 2008.

103. Passeri G., Vescovini R., Sansoni P., Galli C., Franceschi C., Passeri M. Italian Multicentric Study on Centenarians (IMUSCE). Calcium metabolism and vitamin D in the extreme longevity. Exp Gerontol 43: 79-87, 2008.

104. Ravaglia G., Forti P., Montesi F., Lucicesare A., Pisacane N., Rietti E., Dalmonte E., Bianchin M., Mecocci P. Mild Cognitive Impairment: epidemiology and dementia risk in an elderly Italian population. J Am Geriatr Soc 56: 51-58, 2008.

105. Mariani E., Monastero R., Ercolani S., Rinaldi P., Mangialasche F., Costanzi E., Vitale D.F., Senin U., Mecocci P. for the ReGAl study group. Influence of comorbidity and cognitive status on instrumental activities of daily living in amnestic MCI: Results from the ReGAl project. Int J Geriatr Psychiatry Int J Geriatr Psychiatry 23: 523-530, 2008.

106. Mariani E., Mangialasche F., Feliziani F.T., Cecchetti R., Malavolta M., Bastiani P., Baglioni M., Dedoussis G., Fulop T., Herbein G., Jajte J., Monti D., Rink L., Mocchegiani E., Mecocci P. Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects. Exp Gerontol 43: 445-451, 2008.

107. Caputo M., Monastero R., Mariani E., Santucci A., Mangialasche F., Camarda R., Senin U., Mecocci P. Neuropsychiatric symptoms in 921 subjects with dementia: a comparison between vascular and neurodegenerative types. Acta Psych Scand 117: 455-464, 2008.

108. Ravaglia G., Forti P., Lucicesare A., Pisacane N., Rietti E., Mangialasche F., Cecchetti R., Patterson C., Mecocci P. Plasma tocopherols and risk of cognitive impairment in an elderly Italian cohort. Am J Clin Nutr 87: 1306-1113, 2008.

109. Emre M., Mecocci P., Stender K. Pooled analyses on cognitive effects of memantine in patients with moderate to severe Alzheimer’s disease. J Alzheimers Dis 14: 193-199, 2008.

110. Quaranta D., Bizzarro A., Marra C., Seripa D., Matera M.G., Sebastiani V., Mecocci P., Masullo C. Psychotic Symptoms in Alzheimer’s Disease and 5-HTTLPR Polymorphism of the Serotonin Transporter Gene: Evidence for an Association. J Alzheimers Dis 16: 173-180, 2009.

111. Mecocci P., Bladström A., Stender K. Effects of memantine on cognition in patients with moderate to severe Alzheimer’s disease: post-hoc analyses of ADAS-cog and SIB total and single-item scores from six randomized, double-blind, placebo-controlled studies. Int J Geriatr Psychiatry 24: 532-538, 2009.

112. Mangialasche F., Polidori M.C., Monastero R., Ercolani S., Camarda C., Cecchetti R., Mecocci P. Biomarkers of oxidative and nitrosative damage in Alzheimer’s disease and mild cognitive impairment. Aging Res Rev 8: 285-305, 2009.

113. Polidori M.C., Praticó D., Mangialasche F., Mariani E., Aust O., Anlasik T., Mang N., Pientka L., Stahl W., Sies H., Mecocci P., Nelles G. High fruit and vegetable intake is positively correlated with antioxidant status and cognitive performance in healthy subjects. J Alzheimer Dis 17: 921-927, 2009.

114. Pilotto A., Franceschi M., D’Onofrio G, Bizzarro A., Mangialasche F., Cascavilla L., Paris F., Matera M.G., Pilotto A., Daniele A., Mecocci P., Masullo C., Dallapiccola B., Seripa D. Effect of a CYP2D6 polymorphism on the efficacy of donepezil in Alzheimer’s disease patients. Neurology 73: 761-767, 2009.

115. Lovestone S., Francis P., Kloszewska I., Mecocci P., Simmons A., Soininen H., Spenger C., Tsolaki M., Vellas B., Wahlund L.O., Ward M. AddNeuroMed Consortium. AddNeuroMed--the European collaboration for the discovery of novel biomarkers for Alzheimer's disease. Ann N Y Acad Sci 1180: 36-46; 2009.

116. Simmons A., Westman E., Muehlboeck S., Mecocci P., Vellas B., Tsolaki M., Kłoszewska I., Wahlund L.O., Soininen H., Lovestone S., Evans A., Spenger C. AddNeuroMed Consortium. MRI













measures of Alzheimer's disease and the AddNeuroMed study. Ann N Y Acad Sci 1180: 47-55; 2009.

117. Giacconi R., Kanoni S., Mecocci P., Malavolta M., Richter D., Pierpaoli S., Costarelli L., Cipriano C., Muti E., Mangialasche F., Piacenza F., Tesei S., Galeazzi R., Theodoraki E.V., Lattanzio F., Dedoussis G., Mocchegiani E. Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort. J Nutr Biochem 21: 1008-1014, 2010.

118. Forti P., Rietti E., Pisacane N., Olivelli V., Dalmonte E., Mecocci P., Ravaglia G. Blood homocysteine and risk of depression in the elderly. Arch Gerontol Geriatr 51: 21-25; 2010.

119. Aldred S., Mecocci P. Decreased dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) concentrations in plasma of Alzheimer's disease (AD) patients. Arch Gerontol Geriatr 51:e16-e18; 2010.

120. Aldred S., Bennett S., Mecocci P. Increased low-density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease. Clin Biochem 43: 267-271; 2010.

121. Hurt C.S., Banerjee S., Tunnard C., Whitehead D., Tsolaki M., Mecocci P., Kloszewska I., Soininen H., Vellas B., Lovestone S. AddNeuroMed Consortium. Insight, cognition and quality of life in Alzheimer's disease. J Neurol Neurosurg Psychiatry 81: 331-336; 2010.

122. Cherubini A., Lowenthal D.T., Paran E., Mecocci P., Williams L.S., Senin U. Hypertension and cognitive function in the elderly. Dis Mon 56: 106-147; 2010.

123. Scafato E., Gandin C., Galluzzo L., Ghirini S., Cacciatore F., Capurso A., Solfrizzi V., Panza F., Cocchi A., Consoli D., Enzi G., Frisoni G.B., Gandolfo C., Giampaoli S., Inzitari D., Maggi S., Crepaldi G., Mariotti S., Mecocci P., Motta M., Negrini R., Postacchini D., Rengo F., Farchi G. I.PR.E.A. Working Group. Prevalence of Aging-Associated Cognitive Decline - AACD in an Italian elderly population: results from the cross sectional phase of the Italian PRoject on the Epidemiology of Alzheimer's disease (I.PR.E.A.). Aging Clin Exp Res 22: 440-449, 2010.

124. Forti P., Pisacane N., Rietti E., Lucicesare A., Olivelli V., Mariani E., Mecocci P., Ravaglia G. Metabolic syndrome and risk of dementia in older adults. J Am Geriatr Soc 58: 487-492, 2010.

125. Mangialasche F., Kivipelto M., Mecocci P., Rizzuto D., Palmer K., Winblad B., Fratiglioni L. High plasma levels of vitamin E forms and reduced Alzheimer’s disease risk in advanced age. J Alzheimers Dis 20: 1029-1037; 2010.

126. Liu Y., Paajanen T., Zhang Y., Westman E., Wahlund L.O., Simmons A., Tunnard C., Sobow T., Mecocci P., Tsolaki M., Vellas B., Muehlboeck S., Evans A., Spenger C., Lovestone S., Soininen H. for the AddNeuroMed Consortium. Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease. Neurobiol Aging 31: 1375-1385; 2010.

127. Thambisetty M., Simmons A., Velayudhan L., Hye A., Campbell J., Zhang Y., Wahlund L.O., Westman E., Kinsey A., Güntert A., Proitsi P., Powell J., Causevic M., Killick R., Lunnon K., Lynham S., Broadstock M., Choudhry F., Howlett D.R., Williams R.J., Sharp S.I., Mitchelmore C., Tunnard C., Leung R., Foy C., O'Brien D., Breen G., Furney S.J., Ward M., Kloszewska I., Mecocci P., Soininen H., Tsolaki M., Vellas B., Hodges A., Murphy D.G., Parkins S., Richardson J.C., Resnick S.M., Ferrucci L., Wong D.F., Zhou Y., Muehlboeck S., Evans A., Francis P.T., Spenger C., Lovestone S. Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry 67: 739-748; 2010.

128. Mangialasche F., Solomon A., Winblad B., Mecocci P., Kivipelto M. Alzheimer’s disease: clinical trials and drug development. Lancet Neurol 9: 702-716; 2010.

129. Feliziani F.T., Polidori M.C., De Rango P., Mangialasche F., Monastero R., Ercolani S., Raichi T., Cornacchiola V., Nelles G., Cao P., Mecocci P. Cognitive performance in elderly patients undergoing carotid endarterectomy or carotid artery stenting: a twelve-month follow-up study. Cerobrovascular Dis 30: 244-251; 2010.

130. Maggio D., Ercolani S., Andreani S., Ruggiero C., Mariani E., Mangialasche F., Palmari N., Mecocci P. Emotional and psychological distress of persons involved in the care of patients with Alzheimer disease predicts falls and fractures in their care recipients. Dement Geriatr Cogn Disord 30: 33-38; 2010.

131. Liu Y., Paajanen T., Westman E., Wahlund L.O., Simmons A., Tunnard C., Sobow T., Proitsi P., Powell J., Mecocci P., Tsolaki M., Vellas B., Muehlboeck S, Evans A., Spenger C., Lovestone S., Soininen H. AddNeuroMed Consortium. Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. J Alzheimers Dis 21: 947-966; 2010.

132. Liu Y., Paajanen T., Westman E., Zhang Y., Wahlund L.O., Simmons A., Tunnard C., Sobow T.,














Proitsi P., Powell J., Mecocci P., Tsolaki M., Vellas B., Muehlboeck S., Evans A., Spenger C., Lovestone S., Soininen H. APOE ε2 allele is associated with larger regional cortical thicknesses and volumes. Dement Geriatr Cogn Disord 30: 229-237; 2010.

133. Paajanen T., Hänninen T., Tunnard C., Mecocci P., Sobow T., Tsolaki M., Vellas B., Lovestone S., Soininen H., Addneuromed Consortium. CERAD neuropsychological battery total score in multinational mild cognitive impairment and control populations: the AddNeuroMed study. J Alzheimers Dis 22: 1089-1097, 2010.

134. Liu Y., Paajanen T., Zhang Y., Westman E., Wahlund L.O., Simmons A., Tunnard C., Sobow T., Mecocci P., Tsolaki M., Vellas B., Muehlboeck S., Evans A., Spenger C., Lovestone S., Soininen H. for the AddNeuroMed Consortium. Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study. Neurobiol Aging 32: 1198-1206, 2011.

135. Westman E., Simmons A., Zhang Y., Muehlboeck J.S., Tunnard C., Liu Y., Collins L., Evans A., Mecocci P., Vellas B., Tsolaki M., Kłoszewska I., Soininen H., Lovestone S., Spenger C., Wahlund L.O. for the AddNeuroMed consortium. Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls. Neuroimage 54: 1178-1187, 2011.

136. Seripa D., Bizzarro A., Pilotto A., D’onofrio G., Vecchione G., Gallo A.P., Cascavilla L., Paris F., Grandone E., Mecocci P., Santini S.A., Masullo C., Pilotto A. Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease. Pharmacogenet Genomics 21: 225-230, 2011.

137. Tunnard C., Whitehead D., Hurt C., Wahlund L., Mecocci P., Tsolaki M., Vellas B., Spenger C., Kłoszewska I., Soininen H., Lovestone S., Simmons A. on behalf of the AddNeuroMed Consortium. Apathy and cortical atrophy in Alzheimer's disease. Int J Geriatr Psychiatry 26: 741-748, 2011.

138. Furney S.J., Simmons A., Breen G., Pedroso I., Lunnon K., Proitsi P., Hodges A., Powell J., Wahlund L.O., Kloszewska I., Mecocci P., Soininen H., Tsolaki M., Vellas B., Spenger C., Lathrop M., Shen L., Kim S., Saykin A.J., Weiner M.W., Lovestone S. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol Psychiatry 16: 1130-1138, 2011.

139. Simmons A., Westman E., Muehlboeck S., Mecocci P., Vellas B., Tsolaki M., Kłoszewska I., Wahlund L.O., Soininen H., Lovestone S., Evans A., Spenger C. The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months. Int J Geriatr Psychiatry 26: 75-82, 2011.

140. Costafreda SG, Dinov ID, Tu Z, Shi Y, Liu CY, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Wahlund LO, Spenger C, Toga AW, Lovestone S, Simmons A. Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment. Neuroimage 56: 212-219, 2011.

141. Tiribuzi R., Orlacchio A., Crispoltoni L., Maiotti M., Zampolini M., De Angeliz M., Mecocci P.,

Cecchetti R., Bernardi G., Datti A., Martino S., Orlacchio A. Lysosomal -Galactosidase and -Hexosaminidase activities correlate with clinical stages of dementia associated with Alzheimer's disease and type 2 diabetes mellitus. J Alzheimers Dis 24: 785-797, 2011.

142. Lupton M.K., Proitsi P., Danillidou M., Tsolaki M., Hamilton G., Wroe R., Pritchard M., Lord K., Martin B.M., Kloszewska I., Soininen H., Mecocci P., Vellas B., Harold D., Hollingworth P., Lovestone S., Powell J.F. Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease. PLoS One 6: e17298, 2011.

143. Sultana R., Mecocci P., Mangialasche F., Cecchetti R., Baglioni M., Butterfield D.A. Increased protein and lipid oxidative damage in mitochondria isolated from lymphocytes from patients with Alzheimer's disease: insights into the role of oxidative stress in Alzheimer's disease and initial investigations into a potential biomarker for this dementing disorder. J Alzheimers Dis 24: 77-84, 2011.

144. Panza F., Seripa D., D'Onofrio G., Frisardi V., Solfrizzi V., Mecocci P., Pilotto A. Neuropsychiatric symptoms, endophenotypes, and syndromes in late-onset Alzheimer's disease: focus on APOE gene. Int J Alzheimers Dis (Article ID 721457), 2011.

145. Westman E., Simmons A., Muehlboeck J.S., Mecocci P., Vellas B., Tsolaki M., Kłoszewska I., Soininen H., Weiner M.W., Lovestone S., Spenger C., Wahlund L.O. for the AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative. AddNeuroMed and ADNI: similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America. Neuroimage 58: 818-828, 2011.











146. Westman E., Cavallin L., Muehlboeck J.S., Zhang Y., Mecocci P., Vellas B., Tsolaki M., Kłoszewska I., Soininen H., Spenger C., Lovestone S., Simmons A., Wahlund L.O. for the AddNeuroMed consortium. Sensitivity and Specificity of Medial Temporal Lobe Visual Ratings and Multivariate Regional MRI Classification in Alzheimer's Disease. PLoS One 6(7):e22506, 2011.

147. Furney S.J., Kronenberg D., Simmons A., Güntert A., Dobson R.J., Proitsi P., Wahlund L.O., Kloszewska I., Mecocci P., Soininen H., Tsolaki M., Vellas B., Spenger C., Lovestone S. Combinatorial markers of mild cognitive impairment conversion to Alzheimer's disease--cytokines and MRI measures together predict disease progression. J Alzheimers Dis. 2011;26 Suppl 3:395-405.

148. Thambisetty M, Simmons A, Hye A, Campbell J, Westman E, Zhang Y, Wahlund LO, Kinsey A, Causevic M, Killick R, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Spenger C, Lovestone S; AddNeuroMed Consortium. Plasma biomarkers of brain atrophy in Alzheimer's disease. PLoS One 6: e28527, 2011.

149. Savino M, Seripa D, Gallo AP, Garrubba M, D'Onofrio G, Bizzarro A, Paroni G, Paris F, Mecocci P, Masullo C, Pilotto A, Santini S.A. Effectiveness of a high-throughput genetic analysis in the identification of responders/non-responders to CYP2D6-metabolized drugs. Clin Lab 57 :887-893, 2011.

150. Pigliautile M., Ricci M., Mioshi E., Ercolani S., Mangialasche F., Monastero R., Croce M.F., Federici S., Mecocci P. Validation study of the Italian Addenbrooke’s Cognitive Examination Revised in a young-old and old-old population. Dementia Geriatr Cogn Disord 32: 301-307, 2011.

151. Ricci M., Cornacchiola V., Pigliautile M., Ercolani S., Mecocci P. Fetal variantof circle of the Willis and bilateral symmetrical parietal stroke. Neurol Sci 33: 309-311, 2012.

152. Whitehead D., Tunnard C., Hurt C., Wahlund L.O., Mecocci P., Tsolaki M., Vellas B., Spenger C., Kłoszewska I., Soininen H., Cromb D., Lovestone S., Simmons A. Frontotemporal atrophy associated with paranoid delusions in women with Alzheimer's disease. Int Psychogeriatr 24: 99-107, 2012.

153. Mecocci P., Polidori M.C. Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease. Biochim Biophys Acta 1822: 631-638, 2012.

154. Bennett S., Grant M., Creese A.J., Mangialasche F., Cecchetti R., Cooper H.J., Mecocci P., Aldred S. Plasma levels of complement 4a protein are increased in Alzheimer's disease. Alzheimer Dis Assoc Disord 26: 329-334, 2012.

155. Mangialasche F., Xu W., Kivipelto M., Costanzi E., Ercolani S., Pigliautile M., Cecchetti R., Baglioni M., Croce M.F., Simmons A., Soininen H., Tsolaki M., Kloszewska I., Vellas B.,

Lovestone S. and Mecocci P., on behalf of the AddNeuroMed Consortium. Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. Neurobiol Aging 33: 2282-2290, 2012.

156. Liu Y, Julkunen V, Paajanen T, Westman E, Wahlund LO, Aitken A, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Spenger C, Lovestone S, Simmons A, Soininen H; AddNeuroMed Consortium. Education increases reserve against Alzheimer's disease-evidence from structural MRI analysis. Neuroradiology 54: 929-938, 2012.

157. Riaño D, Real F, López-Vallverdú JA, Campana F, Ercolani S, Mecocci P, Annicchiarico R, Caltagirone C. An ontology-based personalization of health-care knowledge to support clinical decisions for chronically ill patients. J Biomed Inform 45: 429-446, 2012.

158. Proitsi P, Lupton MK, Dudbridge F, Tsolaki M, Hamilton G, Daniilidou M, Pritchard M, Lord K, Martin BM, Craig D, Todd S, McGuinness B, Hollingworth P, Harold D, Kloszewska I, Soininen H, Mecocci P, Velas B, Gill M, Lawlor B, Rubinsztein DC, Brayne C, Passmore PA, Williams J, Lovestone S, Powell JF. Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. Neurobiol Aging 33: 1843.e9-17, 2012.

159. Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Coppola G, Geschwind D, Simmons A, Lovestone S, Dobson R, Hodges A. Mitochondrial Dysfunction and Immune Activation are Detectable in Early Alzheimer's Disease Blood. J Alzheimers Dis 30: 685-710, 2012.

160. Galeotti F, Vanacore N, Gainotti S, Izzicupo F, Menniti-Ippolito F, Petrini C, Chiarotti F, Chattat R, Raschetti R; AdCare Study Group. How legislation on decisional capacity can negatively affect the feasibility of clinical trials in patients with dementia . Drugs Aging 29: 607-614, 2012.
















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161. Lourdusamy A, Newhouse S, Lunnon K, Proitsi P, Powell J, Hodges A, Nelson SK, Stewart A, Williams S, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Lovestone S; AddNeuroMed Consortium, Dobson R Alzheimer's Disease Neuroimaging Initiativ. Identification of cis-regulatory variation influencing protein abundance levels in human plasma. Hum Mol Genet 21: 3719-3726, 2012.

162. Di Domenico F, Barone E, Mancuso C, Perluigi M, Cocciolo A, Mecocci P, Butterfield DA, Coccia R. HO-1/BVR-A System Analysis in Plasma from Probable Alzheimer's Disease and Mild Cognitive Impairment Subjects: A Potential Biochemical Marker for the Prediction of the Disease. J Alzheimers Dis 32: 277-289, 2012.

163. Polidori MC, Pientka L, Mecocci P. A review of the major vascular risk factors related to Alzheimer's disease. J Alzheimers Dis 32: 521-530, 2012.

164. Cocciolo A, Di Domenico F, Coccia R, Fiorini A, Cai J, Pierce WM, Mecocci P, Butterfield DA, Perluigi M. Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights from redox proteomics. Free Radic Biol Med 53: 1868-1876, 2012.

165. Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, Lunnon K, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Mecocci P, Lovestone S, Newhouse S, Dobson R; for the Alzheimers Disease Neuroimaging Initiative. Plasma Based Markers of [11C] PiB-PET Brain Amyloid Burden. PLoS One 7(9):e44260, 2012. Epub 2012 Sep 24.

166. Greco I, Day N, Riddoch-Contreras J, Reed J, Soininen H, K 322 Oszewska I, Tsolaki M, Vellas B, Spenger C, Mecocci P, Wahlund LO, Simmons A, Barnes J, Lovestone SS. Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation. J Transl Med. 2012 Oct 31;10(1):217.

167. Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Geschwind D, Lovestone S, Dobson R, Hodges A. A Blood Gene Expression Marker of Early Alzheimer's Disease. J Alzheimers Dis 33: 737-753, 2013.

168. Velayudhan L, Proitsi P, Westman E, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Spenger C, Hodges A, Powell J, Lovestone S, Simmons A. Entorhinal Cortex Thickness Predicts Cognitive Decline in Alzheimer's Disease. J Alzheimers Dis 33: 755-766, 2013.

169. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J; Alzheimer Genetic Analysis Group. TREM2 variants in Alzheimer's disease. N Engl J Med 368: 117-127, 2013.

170. Spulber G, Simmons A, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Spenger C, Lovestone S, Wahlund LO, Westman E; The AddNeuroMed consortium for the Alzheimer Disease Neuroimaging Initiative. An MRI-based index to measure the severity of Alzheimer’s disease-like structural pattern in subjects with mild cognitive impairment. J Intern Med 273: 396-409, 2013.

171. Mangialasche F, Westman E, Kivipelto M, Muehlboeck JS, Cecchetti R, Baglioni M, Tarducci R, Gobbi G, Floridi P, Soininen H, Kłoszewska I, Tsolaki M, Vellas B, Spenger C, Lovestone S, Wahlund LO, Simmons A, Mecocci P; The AddNeuroMed consortium. Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol. J Intern Med 273: 602-621, 2013.

172. Gallucci M, Mazzuco S, Ongaro F, Di Giorgi E, Mecocci P, Cesari M, Albani D, Forloni GL, Durante E, Gajo GB, Zanardo A, Siculi M, Caberlotto L, Regini C. Body mass index, lifestyles, physical performance and cognitive decline: the "Treviso Longeva (TRELONG)" study. J Nutr Health Aging 17: 378-384, 2013.

173. Aguilar C, Westman E, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Spenger C, Simmons A, Wahlund LO. Different multivariate techniques for automated classification of MRI data in Alzheimer's disease and mild cognitive impairment. Psychiatry Res 212: 89-98, 2013.

174. Nho K, Corneveaux JJ, Kim S, Lin H, Risacher SL, Shen L, Swaminathan S, Ramanan VK, Liu Y, Foroud T, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR, Weiner MW, Baldwin CT, Lunetta K, Farrer LA; for the Multi-Institutional Research on Alzheimer Genetic Epidemiology (MIRAGE) Study, Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H; for the AddNeuroMed Consortium, McDonald BC, Farlow

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MR, Ghetti B; for the Indiana Memory and Aging Study, Huentelman MJ, Saykin AJ. Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment. Mol Psychiatry 18: 781-787, 2013.

175. Leung R, Proitsi P, Simmons A, Lunnon K, Güntert A, Kronenberg D, Pritchard M, Tsolaki M, Mecocci P, Kloszewska I, Vellas B, Soininen H, Wahlund LO, Lovestone S. Inflammatory proteins in plasma are associated with severity of Alzheimer's disease. PLoS One 2013 Jun 10;8(6):e64971.

176. Nho K, Corneveaux JJ, Kim S, Lin H, Risacher SL, Shen L, Swaminathan S, Ramanan VK, Liu Y, Foroud T, Inlow MH, Siniard AL, Reiman RA, Aisen PS, Petersen RC, Green RC, Jack CR, Weiner MW, Baldwin CT, Lunetta K, Farrer LA; (MIRAGE) Study, Furney SJ, Lovestone S, Simmons A, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H; AddNeuroMed Consortium, McDonald BC, Farlow MR, Ghetti B; Indiana Memory and Aging Study, Huentelman MJ, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative (ADNI). Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics. Mol Psychiatry 18: 739, 2013.

177. Sultana R, Baglioni M, Cecchetti R, Cai J, Klein JB, Bastiani P, Ruggiero C, Mecocci P, Butterfield D.A. Lymphocyte mitochondria: toward identification of peripheral biomarkers in the progression of Alzheimer disease. Free Radic Biol Med 65: 595-606, 2013.

178. Mangialasche F, Solomon A, Kåreholt I, Hooshmand B, Cecchetti R, Fratiglioni L, Soininen H, Laatikainen T, Mecocci P, Kivipelto M. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. Exp Gerontol 48: 1428-1435, 2013.

179. Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, Destefano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thornton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML,Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Hollingworth P, Ramirez A, Hanon O, Fitzpatrick AL, Buxbaum JD, Campion D, Crane PK, Baldwin C, Becker T, Gudnason V, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ,Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MJ, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuinness B,Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D,Mancuso M, Matthews F; European Alzheimer's Disease Initiative (EADI); Genetic and Environmental Risk in Alzheimer's Disease (GERAD); Alzheimer's Disease Genetic Consortium (ADGC); Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannfelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M,Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV,Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF,Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS,Boerwinkle E, Riemenschneider M, Boada M, Hiltunen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V,Seshadri S, Williams J, Schellenberg GD, Amouyel P. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 45: 1452-1458, 2013.

180. Paajanen T, Hänninen T, Aitken A, Hallikainen M, Westman E, Wahlund LO, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Spenger C, Lovestone S, Simmons A, Soininen H; AddNeuroMed Consortium. CERAD neuropsychological total scores reflect cortical thinning in prodromal Alzheimer's disease. Dement Geriatr Cogn Dis Extra 3: 446-458, 2013.

181. Whiley L, Sen A, Heaton J, Proitsi P, García-Gómez D, Leung R, Smith N, Thambisetty M, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Lovestone S, Legido-Quigley C; AddNeuroMed Consortium. Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease. Neurobiol Aging 35: 271-278, 2014.

182. Ferrucci L, Baroni M, Ranchelli A, Lauretani F, Maggio M, Mecocci P, Ruggiero C. Interaction between bone and muscle in older persons with mobility limitations. Curr Pharm Des. 20: 3178-3197, 2014.

183. Proitsi P, Lee SH, Lunnon K, Keohane A, Powell J, Troakes C, Al-Sarraj S, Furney S, Soininen H,

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Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJ, De Geus EJ, De Jager PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO, Fernández G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Göring HH, Green RC, Gruber O, Gudnason V, Guelfi S, Håberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Huentelman M, Pol HE, Ikeda M, Jack CR, Jenkinson M, Johnson R, Jönsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaître H, Liu X, Longo DL, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Mühleisen TW, Müller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nöthen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernández MC, Van der Brug M, van der Lugt A, van der Wee NJ, Van Haren NE, van 't Ent D, Van Tol MJ, Vardarajan BN, Vellas B, Veltman DJ, Völzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, Martin NG, Van Duijn CM, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM, Ikram MA. Novel genetic loci associated with hippocampal volume. Nat Commun. 2017 Jan 18;8:13624. doi: 10.1038/ncomms13624

250. Boccardi V, Baroni M, Smirne N, Clodomiro A, Ercolani S, Longo A, Ruggiero C, Bruni AC, Mecocci P. Short-Term Response is not Predictive of Long-Term Response to Acetylcholinesterase Inhibitors in Old Age Subjects with Alzheimer's Disease: A "Real World" Study. J Alzheimers Dis 56: 239-248, 2017.

251. Boccardi V., Baroni M., Paolacci L., Ercolani S., Longo A., Giordano M., Ruggiero C., Mecocci P., The Regal Study Group. Anticholinergic burden and functional status in older people with cognitive impairment: Results from the ReGAl project. J Nutr Health Aging 21: 389-396, 2017.

252. Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch-Contreras J, Thubron EB, Devall M, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Schalkwyk L, Dobson R, Malik AN, Powell J, Lovestone S, Hodges A; AddNeuroMed Consortium. Mitochondrial genes are altered in blood early in Alzheimer's disease. Neurobiol Aging 53: 36-47, 2017.

253. Khan W, Giampietro V, Banaschewski T, Barker GJ, Bokde AL, Büchel C, Conrod P, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Lemaître H, Nees F, Paus T, Pausova Z, Rietschel M, Smolka MN, Ströhle A, Gallinat J, Vellas B, Soininen H, Kloszewska I, Tsolaki M, Mecocci P, Spenger C, Villemagne VL, Masters CL, Muehlboeck JS, Bäckman L, Fratiglioni L, Kalpouzos G, Wahlund LO, Schumann G, Lovestone S, Williams SC, Westman E, Simmons A; Alzheimer–s Disease Neuroimaging Initiative.; AddNeuroMed Consortium, Australian, Imaging, Biomarkers, and Lifestyle Study Research Group.; IMAGEN consortium. A Multi-Cohort Study of ApoE ɛ4 and Amyloid-β Effects on the Hippocampus in Alzheimer's Disease. J Alzheimers Dis 56: 1159-1174, 2017.

254. Proitsi P, Kim M, Whiley L, Simmons A, Sattlecker M, Velayudhan L, Lupton MK, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Powell JF, Dobson RJ, Legido-Quigley C. Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis. Alzheimers Dement 13: 140-151, 2017.

255. Bosco P, Redolfi A, Bocchetta M, Ferrari C, Mega A, Galluzzi S, Austin M,Chincarini A, Collins DL, Duchesne S, Maréchal B, Roche A, Sensi F, Wolz R, Alegret M, Assal F, Balasa M, Bastin C, Bougea A, Emek-Savaş DD, Engelborghs S, Grimmer T, Grosu G, Kramberger MG, Lawlor B, Mandic Stojmenovic G, Marinescu M, Mecocci P, Molinuevo JL, Morais R, Niemantsverdriet E, Nobili F, Ntovas K, O'Dwyer S, Paraskevas GP, Pelini L, Picco A, Salmon E, Santana I, Sotolongo-Grau O, Spiru L, Stefanova E, Popovic KS, Tsolaki M, Yener GG, Zekry D, Frisoni GB. The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: An EADC study. Alzheimers Dement 2017 Mar 3. pii:






Formattato: Tipo di carattere: (Predefinito) Arial, Colorecarattere: Automatico





































https://www.ncbi.nlm.nih.gov/pubmed/?term=Proitsi%20P%5BAuthor%5D&cauthor=true&cauthor_uid=27693183

https://www.ncbi.nlm.nih.gov/pubmed/?term=Kim%20M%5BAuthor%5D&cauthor=true&cauthor_uid=27693183

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https://www.ncbi.nlm.nih.gov/pubmed/?term=Sattlecker%20M%5BAuthor%5D&cauthor=true&cauthor_uid=27693183


https://www.ncbi.nlm.nih.gov/pubmed/?term=Lupton%20MK%5BAuthor%5D&cauthor=true&cauthor_uid=27693183

https://www.ncbi.nlm.nih.gov/pubmed/?term=Soininen%20H%5BAuthor%5D&cauthor=true&cauthor_uid=27693183

https://www.ncbi.nlm.nih.gov/pubmed/?term=Kloszewska%20I%5BAuthor%5D&cauthor=true&cauthor_uid=27693183

https://www.ncbi.nlm.nih.gov/pubmed/?term=Mecocci%20P%5BAuthor%5D&cauthor=true&cauthor_uid=27693183

https://www.ncbi.nlm.nih.gov/pubmed/?term=Tsolaki%20M%5BAuthor%5D&cauthor=true&cauthor_uid=27693183

https://www.ncbi.nlm.nih.gov/pubmed/?term=Vellas%20B%5BAuthor%5D&cauthor=true&cauthor_uid=27693183

https://www.ncbi.nlm.nih.gov/pubmed/?term=Lovestone%20S%5BAuthor%5D&cauthor=true&cauthor_uid=27693183

https://www.ncbi.nlm.nih.gov/pubmed/?term=Powell%20JF%5BAuthor%5D&cauthor=true&cauthor_uid=27693183

https://www.ncbi.nlm.nih.gov/pubmed/?term=Dobson%20RJ%5BAuthor%5D&cauthor=true&cauthor_uid=27693183





S1552-5260(17)30045-6. doi: 10.1016/j.jalz.2017.01.019. [Epub ahead of print]

256. Ruggiero C., Bonamassa L., Pelini L., Prioletta I., Cianferotti L., Metozzi A., Benvenuti E., Brandi G., Guazzini A., Santoro G.C., Mecocci P., Black D., Brandi M.L. Early post-surgical cognitive dysfunction is a risk factor for mortality among hip fracture hospitalized older persons. Osteoporos Int 28: 667-675, 2017.

257. Ferreira D., Hansson O., Barroso J., Molina Y., Machado A., Hernández-Cabrera J.A., Muehlboeck J.-S., Stomrud E., Nägga K., Lindberg O., Ames D., Kalpouzos G., Fratiglioni L., Bäckman L., Graff C., Mecocci P., Vellas B., Tsolaki M., Kłoszewska I., Soininen H., Lovestone S., Ahlström H., Lind L., Larsson E.-M., Wahlund L.-O., Simmons A., Westman E. The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals. Hippocampus, 27:653-667, 2017.

258. Boccardi V, Mecocci P. Telomerase activation and human health-span: an open issue. Aging Clin Exp Res. 2017 May 3. doi: 10.1007/s40520-017-0766-z. [Epub ahead of print] PubMed PMID: 28470632.

259. Paolacci L, Giannandrea D, Mecocci P, Parnetti L. Biomarkers for Early Diagnosis of Alzheimer's Disease in the Oldest Old: Yes or No? J Alzheimers Dis. 58: 323-335, 2017.

260. Chiesi F., Primi C., Pigliautile M., Ercolani S., Conestabile della Staffa M., Longo A., Boccardi V., Mecocci P. The local reliability of the 15-item version of the Geriatric Depression Scale: An item response theory (IRT) study. J Psychosomatic Res 96: 84-88, 2017.

: Mecocci P, MacGarvey U, Kaufman AE, Koontz D, Shoffner JM, Wallace DC, Beal MF. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol. 1993 Oct;34(4):609-16.

2: Mecocci P, MacGarvey U, Beal MF. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann Neurol. 1994 Nov;36(5):747-51.

3: Mecocci P, Cherubini A, Beal MF, Cecchetti R, Chionne F, Polidori MC, Romano G, Senin U. Altered mitochondrial membrane fluidity in AD brain. Neurosci Lett. 1996 Mar 29;207(2):129-32..

4: Mecocci P, Beal MF, Cecchetti R, Polidori MC, Cherubini A, Chionne F, Avellini L, Romano G, Senin U. Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain. Mol Chem Neuropathol. 1997 May;31(1):53-64.

5: Mecocci P, Cherubini A, Senin U. Increased oxidative damage in lymphocytes of Alzheimer's disease patients. J Am Geriatr Soc. 1997 Dec;45(12):1536-7. PubMed PMID: 9400571.

6: Polidori MC, Frei B, Cherubini A, Nelles G, Rordorf G, Keaney JF Jr, Schwamm L, Mecocci P, Koroshetz WJ, Beal MF. Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke. Free Radic Biol Med. 1998 Sep;25(4-5):561-7..

7: Mecocci P, Cherubini A, Bregnocchi M, Chionne F, Cecchetti R, Lowenthal DT, Senin U. Tau protein in cerebrospinal fluid: a new diagnostic and prognostic marker in Alzheimer disease? Alzheimer Dis Assoc Disord. 1998 Sep;12(3):211-4.

8: Mecocci P, Polidori MC, Ingegni T, Cherubini A, Chionne F, Cecchetti R, Senin U. Oxidative damage to DNA in lymphocytes from AD patients. Neurology. 1998 Oct;51(4):1014-7.

9: Mecocci P, Fanó G, Fulle S, MacGarvey U, Shinobu L, Polidori MC, Cherubini A, Vecchiet J, Senin U, Beal MF. Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle. Free Radic Biol Med. 1999 Feb;26(3-4):303-8.

10: Lezza AM, Mecocci P, Cormio A, Beal MF, Cherubini A, Cantatore P, Senin U, Gadaleta MN. Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients. FASEB J. 1999 Jun;13(9):1083-8. PubMed.

11: Polidori MC, Mecocci P, Reimann A, Cherubini A, Cecchetti R, Briviba K, Stahl W, Sies H, Senin U. Plasma lipid peroxidation and vitamin C status in healthy centenarians. J Am Geriatr Soc. 1999 Aug;47(8):1038-9.

12: Polidori MC, Mecocci P, Stahl W, Parente B, Cecchetti R, Cherubini A, Cao P, Sies H, Senin U. Plasma levels of lipophilic antioxidants in very old patients with type 2 diabetes. Diabetes Metab Res Rev. 2000 Jan-Feb;16(1):15-9.

13: Polidori MC, Mecocci P, Cherubini A, Senin U. Physical activity and oxidative stress during aging. Int J Sports Med. 2000 Apr;21(3):154-7.

14: Mecocci P, Polidori MC, Troiano L, Cherubini A, Cecchetti R, Pini G, Straatman M, Monti D, Stahl W, Sies H, Franceschi C, Senin U. Plasma antioxidants and longevity: a study on healthy centenarians. Free Radic Biol Med. 2000 Apr.

15: Cherubini A, Polidori MC, Bregnocchi M, Pezzuto S, Cecchetti R, Ingegni T, di Iorio A, Senin U,











Mecocci P. Antioxidant profile and early outcome in stroke patients. Stroke. 2000 Oct;31(10):2295-300.

16: Fulle S, Mecocci P, Fanó G, Vecchiet I, Vecchini A, Racciotti D, Cherubini A, Pizzigallo E, Vecchiet L, Senin U, Beal MF. Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome. Free Radic Biol Med. 2000 Dec 15;29(12):1252-9.

17: Polidori MC, Cherubini A, Senin U, Mecocci P. Hyperhomocysteinemia and oxidative stress in ischemic stroke. Stroke. 2001 Jan;32(1):275-8.

18: Polidori MC, Mecocci P, Frei B. Plasma vitamin C levels are decreased and correlated with brain damage in patients with intracranial hemorrhage or head trauma. Stroke. 2001 Apr;32(4):898-902. PubMed PMID: 11283389; 15;28(8):1243-8..

19: Polidori MC, Savino K, Alunni G, Freddio M, Senin U, Sies H, Stahl W, Mecocci P. Plasma lipophilic antioxidants and malondialdehyde in congestive heart failure patients: relationship to disease severity. Free Radic Biol Med. 2002 Jan 15;32(2):148-52.

20: Mecocci P, Polidori MC, Cherubini A, Ingegni T, Mattioli P, Catani M, Rinaldi P, Cecchetti R, Stahl W, Senin U, Beal MF. Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease. Arch Neurol. 2002 May;59(5):794-8.

21: Polidori MC, Cherubini A, Stahl W, Senin U, Sies H, Mecocci P. Plasma carotenoid and malondialdehyde levels in ischemic stroke patients: relationship to early outcome. Free Radic Res. 2002 Mar;36(3):265-8.

22: Polidori MC, Mecocci P. Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease. J Alzheimers Dis. 2002 Dec;4(6):517-22.

23: Ingegni T, Nocentini G, Mariani E, Spazzafumo L, Polidori MC, Cherubini A, Catani M, Cadini D, Senin U, Mecocci P. Cathepsin D polymorphism in Italian elderly subjects with sporadic late-onset Alzheimer's disease. Dement Geriatr Cogn Disord. 2003;16(3):151-5.

24: Rinaldi P, Polidori MC, Metastasio A, Mariani E, Mattioli P, Cherubini A, Catani M, Cecchetti R, Senin U, Mecocci P. Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol Aging. 2003 Nov;24(7):915-9.

25: Polidori MC, Mecocci P, Levine M, Frei B. Short-term and long-term vitamin C supplementation in humans dose-dependently increases the resistance of plasma to ex vivo lipid peroxidation. Arch Biochem Biophys. 2004 Mar 1;423(1):109-15.

26: Mecocci P. Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum. J Alzheimers Dis. 2004 Apr;6(2):159-63.

27: Polidori MC, Mattioli P, Aldred S, Cecchetti R, Stahl W, Griffiths H, Senin U, Sies H, Mecocci P. Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia. Dement Geriatr Cogn Disord. 2004;18(3-4):265-70. Epub 2004 Jul 29..

28: Polidori MC, Praticó D, Savino K, Rokach J, Stahl W, Mecocci P. Increased F2 isoprostane plasma levels in patients with congestive heart failure are correlated with antioxidant status and disease severity. J Card Fail. 2004 Aug;10(4):334-8.

29: Mariani E, Polidori MC, Cherubini A, Mecocci P. Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 15;827(1):65-75. Epub 2005 Sep 23

30: Polidori MC, Praticó D, Ingegni T, Mariani E, Spazzafumo L, Del Sindaco P, Cecchetti R, Yao Y, Ricci S, Cherubini A, Stahl W, Sies H, Senin U, Mecocci P; AVASAS Study Group. Effects of vitamin C and aspirin in ischemic stroke-related lipid peroxidation: results of the AVASAS (Aspirin Versus Ascorbic acid plus Aspirin in Stroke) Study. Biofactors. 2005;24(1-4):265-74.

31: Mariani E, Cornacchiola V, Polidori MC, Mangialasche F, Malavolta M, Cecchetti R, Bastiani P, Baglioni M, Mocchegiani E, Mecocci P. Antioxidant enzyme activities in healthy old subjects: influence of age, gender and zinc status: results from the Zincage Project. Biogerontology. 2006 Oct-Dec;7(5-6):391-8.

32: Polidori MC, Mariani E, Baggio G, Deiana L, Carru C, Pes GM, Cecchetti R, Franceschi C, Senin U, Mecocci P. Different antioxidant profiles in Italian centenarians: the Sardinian peculiarity. Eur J Clin Nutr. 2007 Jul;61(7):922-4. Epub 2007 Jan 17.

33: Polidori MC, Griffiths HR, Mariani E, Mecocci P. Hallmarks of protein oxidative damage in neurode-generative diseases: focus on Alzheimer's disease. Amino Acids. 2007;32(4):553-9. Epub 2007 Feb 2.



34: Galli F, Cristina Polidori M, Stahl W, Mecocci P, Kelly FJ. Vitamin E biotransformation in humans. Vitam Horm. 2007;76:263-80.

35: Mariani E, Monastero R, Mecocci P. Mild cognitive impairment: a systematic review. J Alzheimers Dis. 2007 Aug;12(1):23-35.

36: Mariani E, Monastero R, Ercolani S, Mangialasche F, Caputo M, Feliziani FT, Vitale DF, Senin U, Mecocci P; ReGAl Study Group. Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project. Dement Geriatr Cogn Disord. 2007;24(6):448-56. Epub 2007 Nov 1.

37: Mariani E, Mangialasche F, Feliziani FT, Cecchetti R, Malavolta M, Bastiani P, Baglioni M, Dedoussis G, Fulop T, Herbein G, Jajte J, Monti D, Rink L, Mocchegiani E, Mecocci P. Effects of zinc supplementation on antioxidant enzyme activities in healthy old subjects. Exp Gerontol. 2008 May;43(5):445-51. Epub 2007 Nov 1.

38: Caputo M, Monastero R, Mariani E, Santucci A, Mangialasche F, Camarda R, Senin U, Mecocci P. Neuropsychiatric symptoms in 921 elderly subjects with dementia: a comparison between vascular and neurodegenerative types. Acta Psychiatr Scand. 2008 Jun;117(6):455-64. Epub 2008 Mar 19.

39: Ravaglia G, Forti P, Lucicesare A, Pisacane N, Rietti E, Mangialasche F, Cecchetti R, Patterson C, Mecocci P. Plasma tocopherols and risk of cognitive, impairment in an elderly Italian cohort. Am J Clin Nutr. 2008 May;87(5):1306-13.

40: Mangialasche F, Polidori MC, Monastero R, Ercolani S, Camarda C, Cecchetti R, Mecocci P. Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment. Ageing Res Rev. 2009 Oct;8(4):285-305. Epub 2009 Apr 17.

41: Polidori MC, Praticó D, Mangialasche F, Mariani E, Aust O, Anlasik T, Mang N, Pientka L, Stahl W, Sies H, Mecocci P, Nelles G. High Fruit and Vegetable Intake is Positively Correlated with Antioxidant Status and Cognitive Performance in Healthy Subjects. J Alzheimers Dis. 2009 Jun 19. [Epub ahead of print].

42: Forti P, Rietti E, Pisacane N, Olivelli V, Dalmonte E, Mecocci P, Ravaglia G. Blood homocysteine and risk of depression in the elderly. Arch Gerontol Geriatr. 2009 Jul 29. [Epub ahead of print].

43: Aldred S, Mecocci P. Decreased dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) concentrations in plasma of Alzheimer's disease (AD) patients. Arch Gerontol Geriatr. 2009 Aug 7. [Epub ahead of print].

44: Aldred S, Bennett S, Mecocci P. Increased low-density lipoprotein oxidation, but not total plasma protein oxidation, in Alzheimer's disease. Clin Biochem. 2009 Sep 4. [Epub ahead of print] PubMed PMID: 19733555.

45: Ravaglia G, Forti P, Montesi F, Lucicesare A, Pisacane N, Rietti E, Dalmonte E, Bianchin M, Mecocci P. Mild cognitive impairment: epidemiology and dementia risk in an elderly Italian population. J Am Geriatr Soc. 2008 Jan;56(1):51-8. Epub 2007 Nov 20.

46: Quaranta D, Bizzarro A, Marra C, Vita MG, Seripa D, Pilotto A, Sebastiani V, Mecocci P, Masullo C. Psychotic symptoms in Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: evidence for an association. J Alzheimers Dis. 2009 Jan;16(1):173-80.

47: Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H; for the AddNeuroMed Consortium. Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups-The AddNeuroMed study. Neurobiol Aging. 2009 Aug 13. [Epub ahead of print].

48: Pilotto A, Franceschi M, D'Onofrio G, Bizzarro A, Mangialasche F, Cascavilla L, Paris F, Matera MG, Pilotto A, Daniele A, Mecocci P, Masullo C, Dallapiccola B, Seripa D. Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease. Neurology. 2009 Sep 8;73(10):761-7. PubMed PMID: 19738170.

49: Hurt CS, Banerjee S, Tunnard C, Whitehead D, Tsolaki M, Mecocci P, Kloszewska I, Soininen H, Vellas B, Lovestone S. Insight, Cognition and Quality of Life in Alzheimer'S Disease. J Neurol Neurosurg Psychiatry. 2009 Oct 13. [Epub ahead of print].

50: Lovestone S, Francis P, Kloszewska I, Mecocci P, Simmons A, Soininen H, Spenger C, Tsolaki M, Vellas B, Wahlund LO, Ward M; AddNeuroMed Consortium. AddNeuroMed--the European collaboration for the discovery of novel biomarkers for Alzheimer's disease. Ann N Y Acad Sci. 2009 Oct;1180:36-46.

51: Simmons A, Westman E, Muehlboeck S, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Wahlund LO, Soininen H, Lovestone S, Evans A, Spenger C; AddNeuroMed Consortium. MRI measures of Alzheimer's disease and the AddNeuroMed study. Ann N Y Acad Sci. 2009 Oct;1180:47-55.



52: Giacconi R, Kanoni S, Mecocci P, Malavolta M, Richter D, Pierpaoli S, Costarelli L, Cipriano C, Muti E, Mangialasche F, Piacenza F, Tesei S, Galeazzi R, Theodoraki EV, Lattanzio F, Dedoussis G, Mocchegiani E. Association of MT1A haplotype with cardiovascular disease and antioxidant enzyme defense in elderly Greek population: comparison with an Italian cohort. J Nutr Biochem. 2009 Dec 3. [Epub ahead of print]

53: Somberg J, Cherubini A, Lowenthal DT, Paran E, Mecocci P, Williams LS, Senin, U, Hahr AJ, Molitch ME, Cheng JW, Frishman WH, Aronow WS. Topics in clinical pharmacology: cardiovascular and diabetes mellitus. Dis Mon. 2010 Mar;56(3):105-79

54: Scafato E, Gandin C, Galluzzo L, Ghirini S, Cacciatore F, Capurso A, Solfrizzi V, Panza F, Cocchi A, Consoli D, Enzi G, Frisoni GB, Gandolfo C, Giampaoli S, Inzitari D, Maggi S, Crepaldi G, Mariotti S, Mecocci P, Motta M, Negrini R, Postacchini D, Rengo F, Farchi G; I.PR.E.A. Working Group (Italian PRoject on Epidemiology of Alzheimer’s disease). Prevalence of Aging-Associated Cognitive Decline - AACD in an Italian elderly population: results from the cross sectional phase of the Italian PRoject on the Epidemiology of Alzheimer's disease (I.PR.E.A.). Aging Clin Exp Res. 2010 Apr 9. [Epub ahead of print].

55: Forti P, Pisacane N, Rietti E, Lucicesare A, Olivelli V, Mariani E, Mecocci P, Ravaglia G. Metabolic syndrome and risk of dementia in older adults. J Am Geriatr Soc. 2010 Mar;58(3):487-92.

56: Mangialasche F, Kivipelto M, Mecocci P, Rizzuto D, Palmer K, Winblad B, Fratiglioni L. High Plasma Levels of Vitamin E Forms and Reduced Alzheimer's Disease Risk in Advanced Age. J Alzheimers Dis. 2010 Apr 22. [Epub ahead of print].

57: Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H; AddNeuroMed Consortium. Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease. Neurobiol Aging. 2010 May 4. [Epub ahead of print].

58: Mangialasche F, Solomon A, Winblad B, Mecocci P, Kivipelto M. Alzheimer’s disease: clinical trials and drug development. Lancet Neurol 2010 July. [Epub ahead of print].

59: Feliziani FT, Polidori MC, De Rango P, Mangialasche F, Monastero R, Ercolani S, Raichi T, Cornacchiola V, Nelles G, Cao P, Mecocci P. Cognitive performance in elderly patients undergoing carotid endarterectomy or carotid artery stenting: a twelve-month follow-up study. Cerebrovasc Dis. 2010 Aug;30(3):244-51. Epub 2010 Jul 24. PubMed PMID: 20664257.

60: Maggio D, Ercolani S, Andreani S, Ruggiero C, Mariani E, Mangialasche F, Palmari N, Mecocci P. Emotional and psychological distress of persons involved in the care of patients with Alzheimer disease predicts falls and fractures in their care recipients. Dement Geriatr Cogn Disord. 2010;30(1):33-8. Epub 2010 Jul 30. PubMed PMID: 20689280.

61: Liu Y, Paajanen T, Westman E, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H; AddNeuroMed Consortium. Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. J Alzheimers Dis. 2010;21(3):947-66. PubMed PMID: 20693633.

62: Liu Y, Paajanen T, Westman E, Zhang Y, Wahlund LO, Simmons A, Tunnard C, Sobow T, Proitsi P, Powell J, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Evans A, Spenger C, Lovestone S, Soininen H; AddNeuroMed Consortium. APOE ε2 allele is associated with larger regional cortical thicknesses and volumes. Dement Geriatr Cogn Disord. 2010;30(3):229-37. Epub 2010 Sep 15. PubMed PMID: 20847553.

63: Paajanen T, Hänninen T, Tunnard C, Mecocci P, Sobow T, Tsolaki M, Vellas B, Lovestone S, Soininen H, Addneuromed Consortium. CERAD neuropsychological battery total score in multinational mild cognitive impairment and control populations: the AddNeuroMed study. J Alzheimers Dis. 2010;22(4):1089-97. PubMed PMID: 20930314.

64: Furney SJ, Simmons A, Breen G, Pedroso I, Lunnon K, Proitsi P, Hodges A, Powell J, Wahlund LO, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Spenger C, Lathrop M, Shen L, Kim S, Saykin AJ, Weiner MW, Lovestone S. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. Mol Psychiatry. 2010 Nov 30. [Epub ahead of print] PubMed PMID: 21116278.

65: Westman E, Simmons A, Zhang Y, Muehlboeck JS, Tunnard C, Liu Y, Collins L, Evans A, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Lovestone S, Spenger C, Wahlund LO; AddNeuroMed consortium. Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls. Neuroimage. 2011 Jan 15;54(2):1178-87. Epub 2010 Aug 25. PubMed PMID: 20800095.



66: Tunnard C, Whitehead D, Hurt C, Wahlund LO, Mecocci P, Tsolaki M, Vellas B, Spenger C, Kłoszewska I, Soininen H, Lovestone S, Simmons A; AddNeuroMed Consortium. Apathy and cortical atrophy in Alzheimer's disease. Int J Geriatr Psychiatry. 2011 Jul;26(7):741-8. doi: 10.1002/gps.2603. Epub 2010 Sep 27. PubMed PMID: 20872914.

67: Simmons A, Westman E, Muehlboeck S, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Wahlund LO, Soininen H, Lovestone S, Evans A, Spenger C. The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months. Int J Geriatr Psychiatry. 2011 Jan;26(1):75-82. doi: 10.1002/gps.2491. PubMed PMID: 21157852.

68: Sultana R, Mecocci P, Mangialasche F, Cecchetti R, Baglioni M, Butterfield DA. Increased protein and lipid oxidative damage in mitochondria isolated from lymphocytes from patients with Alzheimer's disease: insights into the role of oxidative stress in Alzheimer's disease and initial investigations into a potential biomarker for this dementing disorder. J Alzheimers Dis. 2011;24(1):77-84. PubMed PMID: 21383494.

69: Lupton MK, Proitsi P, Danillidou M, Tsolaki M, Hamilton G, Wroe R, Pritchard M, Lord K, Martin BM, Kloszewska I, Soininen H, Mecocci P, Vellas B, Harold D, Hollingworth P, Lovestone S, Powell JF. Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease. PLoS One. 2011 Feb 25;6(2):e17298. PubMed PMID: 21364883; PubMed Central PMCID: PMC3045431.

70: Costafreda SG, Dinov ID, Tu Z, Shi Y, Liu CY, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Wahlund LO, Spenger C, Toga AW, Lovestone S, Simmons A. Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment. Neuroimage. 2011 May 1;56(1):212-9. Epub 2011 Jan 25. PubMed PMID: 21272654; PubMed Central PMCID: PMC3066277.

71: Seripa D, Bizzarro A, Pilotto A, D'onofrio G, Vecchione G, Gallo AP, Cascavilla L, Paris F, Grandone E, Mecocci P, Santini SA, Masullo C, Pilotto A. Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease. Pharmacogenet Genomics. 2011 Apr;21(4):225-30. PubMed PMID: 20859244.

72: Panza F, Seripa D, D'Onofrio G, Frisardi V, Solfrizzi V, Mecocci P, Pilotto A. Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late-Onset Alzheimer's Disease: Focus on APOE Gene. Int J Alzheimers Dis. 2011 Apr 7;2011:721457. PubMed PMID: 21559196; PubMed Central PMCID: PMC3090058.

73: Ricci M, Cornacchiola V, Pigliautile M, Ercolani S, Mecocci P. Fetal variant of circle of the Willis and bilateral symmetrical parietal stroke. Neurol Sci. 2011 Jul 6. [Epub ahead of print] PubMed PMID: 21732065.

74: Westman E, Cavallin L, Muehlboeck JS, Zhang Y, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Spenger C, Lovestone S, Simmons A, Wahlund LO; for the AddNeuroMed consortium. Sensitivity and Specificity of Medial Temporal Lobe Visual Ratings and Multivariate Regional MRI Classification in Alzheimer's Disease. PLoS One. 2011;6(7):e22506. Epub 2011 Jul 21. PubMed PMID: 21811624.

75: Westman E, Simmons A, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Weiner MW, Lovestone S, Spenger C, Wahlund LO; for the AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initiative. AddNeuroMed and ADNI: Similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America. Neuroimage. 2011 Jul 1. [Epub ahead of print] PubMed PMID: 21763442.

BC. Ricerche finanziate Partner in the ZINCAGE, a specific targeted research project (STREP) funded by the European

Union in the 6th Framework Program (FP6): "Food Quality and Safety", Priority 5, Thematic Area T6: This topic involves epidemiological studies on the influence of diet and lifestyle on healthy ageing, aimed at preventing adult degenerative disease, particularly focusing on cardiovascular diseases and also addressing malnutrition of the elderly. Contract n° 506850

Partner in the InnoMed (Innovative Medicines for Europe) Project, funded by the European Union in the 6th Framework Program (FP6): Life Science Health, Priority 5. Contract n° 518170.

Partner in the K4Care Project (Knowledge-Based Homecare eServices for an Ageing Europe), funded by the European Union in the 6th Framework Program (FP6): Information, Society, Technology, Priority 2. Contract n° 026968

Principal Investigator of the project PRIN 2007 MIUR Oxidative and nitrosative damage of mitochondrial proteins in models of cell senescence and in subjects with Alzheimer's disease: a

Formattato: Tipo di carattere: Grassetto




pre-clinical study on natural forms and new synthetic analogues of vitamin E.

Partner in the project Giovani Ricercatori 2007 Ministero della Salute Epidemiology and risk factors for Mild Cognitive Impairment, Alzheimer’s disease and dementias The Zabùt Aging Project: a 5 years follow-up study on a rural Sicilian community.

Principal Investigator Progetto Fondazione Cassa di Risparmio di Perugia 2009 Biomarkers of inflammation, cognitive functions and risk for Alzheimer’s disease in an elderly population.

Partner in the Project of the Alzheimer's Association (USA) 2010: Effect of preventive interventions on biomarkers for cognitive decline.

Partner in the project Ministero della Salute 2013 Implementazione di un modello organizzativo integrato per la gestione del paziente con demenza: dalla prevenzione alla cura con presa in carico.

Principal Investigator Progetto MusicalMente Regione Umbria 2013 Progetto socio-sanitario per la valutazione dell'efficacia della musicoterapia su pazienti con deterioramento cognitivo cronico progressivo.

Partner in the Project of the Swedish Research Council 2013 The body-mind connection: exploring the biological mechanisms underlying the effects of somatic health on brain aging.

Partner in the Project PredictND funded by the European Union in the 7th Framework Program (FP7) From patient data to clinical diagnosis in neurodegenerative diseases. Contract n° 611005.

Principal Investigator of the project Ministero della Salute (MINSAL) (codice RF-2013-02359594) "Vitamin E, miRNA and inflammation: a tunable network in Alzheimer's disease.”

Partner in the Project Ambient and Assisted Living-AAL 2016 MEMENTO

2008-2010 PRIN Ministero dell’Università e ricerca scientifica. Mecocci P (PI) Oxidative and nitrosative damage of mitochondrial proteins in models of cell senescence and in subjects with Alzheimer's disease: a pre-clinical study on natural forms and new synthetic analogues of vitamin E.

Ruolo: responsabile del progetto

2010-2012 Ministero della salute ( progetti per giovani ricercatori), Monastero R. (PI) Epidemiology and risk factors for mild cognitive impairment, Alzheimer’s diseases and other dementias in a Sicilian rural population. The Zabùt Aging Project

Ruolo: ricercatore

2005-2008 ZINCAGE Moccheggiani E. (PI), specific targeted research project (STREP) finanziato dalla Unione Europea ( 6th Framework Program (FP6):Food Quality and Safety Epidemiological study on the influence of diet and lifestyle on healthy ageing, aimed at preventing adult degenerative disease). Contratto n° 506850

Ruolo: ricercatore

2006-2009 AddNeuroMed-InnoMed (Innovative Medicines for Europe) Lovestone S. (PI) progetto finanziato dalla Unione Europea ( 6th Framework Program (FP6): Life Science Health. Achievement accelerated development of safe and more effective medicines for Alzheimer’s disease with the use of biological markers ). Contratto n° 518170.

Ruolo: ricercatore

2006-2009 K4Care Project (Knowledge-Based Homecare Services for an Ageing Europe) Riaňo D. (PI) finanziato dalla Unione Europea ( 6th Framework Program (FP6):Information, Society, Technology. The main objective of the K4CARE project is to improve the capabilities of the new EU society to manage and respond to the increasing number of senior population requiring a personalized healthcare assistance. Development of an intelligent web platform in order to give service to health professionals, patients, and citizens in general). Contratto n° 026968

Ruolo: ricercatore

Il sottoscritto è a conoscenza che, ai sensi dell’art. 26 della legge 15/68, le dichiarazioni mendaci, la falsità negli atti e l’uso di atti falsi sono puniti ai sensi del codice penale e delle leggi speciali. Inoltre, il sottoscritto autorizza al trattamento dei dati personali, secondo quanto previsto dalla Legge 675/96 del 31 dicembre 1996.





Perugia, 4 dicembre 201231 maggio 2017

Prof.ssa Patrizia Mecocci

Formattato: Rientro: Sinistro: 0 cm

new informazioni personali mecocci patrizia · 2017. 10. 31. · cognome(i) / nome(i) mecocci...

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