667

THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Copyright 0 1973 by The Williams & Wilkins Co.

INDEX

Vol. 187, No. 3Printed in U.S.A.

Volume 187, October-December 1973

Abildskov, J. A., see Urthaler, F., 269

Acetaminophen-iiiduced hepatic necrosis, protective role of

glut.at.hione, 211-induced hepatic necrosis, role of covalent bind-

ing in vivo, 195-induced hepatic necrosis, role of cytochrome

P-450-mediated covalent. binding in vitro, 203-induced hepatic necrosis, role of metabolism,

1852-Acetylaminofluorene, cytochrome P450-depend-

eat binding to microsomes, 203Acetylcholine turnover rate in rat salivary glands,

effect of deafferentation and duet ligation on,measured by steady-state kinetics, 68

Acetylstrophanthidin

effects on spinal cord neural mechanisms, 246inotropic effect, antagonism by aldosterone, 112

Adenosine monophosphate , cyclic , in guinea-pig

heart., increased by phenylephrine, 296Adrenergic blockade, beta, effect on intramyo-

cardial distribution of coronary blood flow,451

Adrenergic neural tone, dependence of sirius node

and atrioventricular junction for automat icityOn, 269

Adrenergic receptoralpha, labeling by ‘4C-Dibenamine, specificity,

524

beta, in isolated rat utertis, relation to mecha-

nism of action of histamine, 511Adrenergic responses, in dog cutaneous vascula-

tore, effects of indomethacin and eicosa-5,8, -11,14-tetraynoic acid (prostaglandin synthesis

inhibitors) on, 315Aldosterone, antagonism of positive inotropic ef-

feet of cardiotonic steroids, 112Alter, W. A., III, Weiss, G. K., Priola, I). V., and

Spurgeon, H. A. : The effects of 6-hydroxy-dopamine on vagal cardioaccelerator systems,99

Amines

biogenic, brain, related to effects of tricyclicantidepressants on attack elicited by hy-

pothalamic stimulation, 550Amines , sympathomimet ic (see Sympat homimetic

amines)Amino acid, hexose and, assimilation by epithe-

hum and muscle of guinea-pig seminal vesicle,

430

Arninoguanidine, effect on metabolism of hista-

mine in brain, 34a-Aminoisobutyric acid, assimilation by epithe-

hum and muscle of guinea-pig seminal vesiele,

430Ammon, H. P. T., Orci, L. and Steinke, J. : Effect

of chlorpromazine (CPZ) on insulin release in

V?t’O and in vitro in the rat, 423

Amodiaquine, effects on metabolism of histamine

in brain, 34

Amphetamine

effects in hypertensive dogs, 308optical isomers, self-administration by rats, 27

d-Amphetaminechlorpromazine , imipramine, morphine and,

self-administration in cocaine-dependent rhe-sus monkeys, 8

morphine and, effects upon locomotor activity ofmice treated with drugs which alter brain

catecholamine content, 1-stimulated behavior in rat, effects of naloxone,

380

d- and i-Amphetamine, effects on fixed-intervaland fixed-ratio behavior in tolerant and non-tolerant rats, 372

Anderson, E. (;., see Taber, C. A., 229

Angiotensin-induced responses in dog gracilismuscle, antagonism by exercise, 78

Antiarrhythmic properties, of UM-272 in canineheart, 260

Anticoagulant action, of dicumarol in rats, effectof phenylbutazone, 176

Antipyrine, metabolism in patients with chronic

renal failure, 612

Antischistosomal drugs

hycanthone effects on spermatogonial cells, de-oxyribonucleic acid synthesis in bone marrow

and dominant lethality in rats, 437

mutagenic act-ion of hycanthone and IA-I on

yeast, 444

Aorta

ral)bit, specificity of alpha adrenergic receptorlabeling by “C-Dibenamine in, 524

rabbit, vascular reaction to vasodilators in, 324

Appel, W. C. and Vincenzi, F. F. : Positive mo-

dopamine , elevation during naloxone-precipi -

668 INDEX Vol. 187

tropic effect of cardiotonic steroids : Differen-tial antagonism by aldosterone, 112

Arachidonic acid, prostaglandins E2 and F� and,

effects on longitudinal stomach strip of rat,501

Archer, R. A., see Lemberger, L., 169

Arias, I. M., see Lichter, M., 612Arthritis, adj uvant-induced, in rat, interactions

of aspirin, indomethacin and other drugs in,

400Aspirin, interactions with indomethacin and other

drugs in adjuvant-induced arthritis in rat., 400Atria, rabbit , aldosterone antagonism of positive

inotropic effect of cardiotonic steroids in, 112

Atrioventricular junction, sinus node and, dog,dependence for ant omaticit.y on adrenergic

neural tone, 269Azathioprine, methylnitroimidazole moiety, met-

abolic fate in rat, 588

Beacham, L. M., III, see de Miranda, P., 588

Behavior

attack, elicited by hypothalamic stimulation,

effects of tricyclic antidepressants related tobrain biogenic amines, 550

cyclazocine-stimulat.ed, in rats, effects of nal-oxone, 380

fixed-interval and fixed-ratio, in tolerant and

nontolerant. rats, effects of d- and l-ampheta-mine, 372

self administration (see Self-administration be-

havior)

Benoist, J. M., see Besson, J. M., 239Benzphet-amine, effects in hypertensive dogs, 308

Berndt, W. 0., see Cooke, W. J. , 158Besson, J. M., Wyon-Maillard, M. C., Benoist,

J. I’sI., Conseiller, C. and Hamann, K. F.:Effects of phenoperidine on lamina V cells inthe cat dorsal horn, 239

Bile, excretion of iopanoate and iophenoxate inrat, effects of phenobarbital and taurocholate,158

Black, M., see Lichter, M., 612Blauw, A. S., II, see Priola, D. V., 121Blood, content in small vessels of canine myocar-

dium, effect of pentrinitrol, nitroglycerin andpropranolol, 465

Blood flowcoronary, beta adrenergic blockade on int.ramyo-

cardial distribution of, 451hepat-ic, d-propranolol clearance and, in mon-

key, increased by glucagon, 581

Boucher, H. , see Langelier, P. , 15Brain

cat, biogenic amines, relation to effects oftricyclic antidepressaiits on attack elicited byhypothalamic stimulation, 550

t ated withdrawal in morphine-dependent mice

and rats, 558mouse, altered catecholamine content, loco-

motor activity and, 1mouse, metabolism of ‘4C-histamine in, 34

type B monoamine oxidase in, �3-pheny1ethyl-amine as specific substrate for, 365

Branch, II. A., Shand, D. 0. and Nies, A. S.:

Hemodynamic drug interactions: The reduc-tion of oxyphenbutazone clearance by dl-propranolol in the dog, 133

Branch, B. A., Shand, I). 0. and Nies, A. S. : In-crease in hepatic blood flow and d-propranololclearance by glucagon in the monkey, 581

Brendel, K. and Meezan, E. : Properties of a puremet abolically act ive glomerular preparation

from rat kidneys. II. Metabolism, 342Brendel, K., see Meezan, E., 332, 352Bretylium tosylate, inotropic action on heart, 121

Briner, W. H., see Somjen, G. C., 602

Bristow, � see (.reen, ii. D., 524

Brodie, B. B.

see J1)llOW, 1.). J. , 195see Mitchell, J. IL, 185, 211

see Potter, W. Z., 203

Brody, M. J., see Powell, J. R., 495

Bromobenzene-induced liver necrosis , role ofdetoxifying enzymes, 218

Brubaker, P. E., see Somjen, C. (1., 602

Bunolol, beta adrenergic blocker, effect. on int.ra-myocardial distribution of coron ary blood

flow, 451

Burcher, E. and Garlick, D. : Antagonism of vaso-constrictor responses by exercise in the gracilis

muscle of the dog, 78Burgess, M. J., see Urthaler, F., 269

Buxbaum, S., set Katchen, B., 152

Cadmium, effects on spermatogenesis studied by

veloci ty sedimentation cell separati on andserial mating, 641

Cafruny, E. J., see Nigrovic, V., 620

Calcium-induced responses of atrial and vascularmuscle, influence of magnesium, 86

Cannabinoid, synthetic (�6a. 10* dimethyl heptyltet rahydrocannabinol) ‘ metabolism , 169

Cannon, W. B., III, see Priola, 1). V., 121

Carbon monoxide, effect on covalent binding in

vitro of acetaminophen in hepatic microsomes,203

Cardiac glycosidesabsorption from rat respiratory tract, 105aglycones and, positive inotropic effect antag-

onized by aldosterone, 112

Cardioaccelerator systems, vagal, effects of 6-hy-droxydopamine, 99

Cardiotonic steroids (cardiac glycosides and

1973 INDEX 669

imiprami tie, morphi ne, d-amphet amine and, self-

aglycones), positive inotropic effect antago-

nized by aldosterone, 112

Cardiovascular effectsof glucagon in cat with chronic heart failure, 475of glyceryl trinitrate and pentrinitrol by dif-

ferent routes of administration in dog, catand rat. , 300

Carlson, E. C., see Meezan, E., 332

Carr, J. V., see Green, S., 437Carrier, 0., Jr., see Turlapat.y, P. D. M. V., 86

Cat(s)blockade by p-chlorophenylalanine of 5-hy-

droxytryptophan facilitatory actions on spinal

reflexes in, 229brain biogenic amines, relation to effects of

tricyclic antidepressant.s on attack elicited byhypothalamic stimulation, 550

Changes in spinal cord neural mechanisms as-

sociat-ed with digitalis in, 246dog, rat and, comparative cardiovascular effects

of glyceryl t.rinitrat.e and pentrinitrol by dif-ferent routes of administration in, 300

dorsal horn, effects of phenoperidine on lamina

V cells in, 239

normal and lesioned, effects of chronically ad-ministered L-dopa, 15

spleen , inhibition by sympathomimet.ic amitiesof nerve stimulat ion -evoked norepinephrinerelease in, 529

��ith chronic heart failure, enhancement of car-

dine performance by glucagon in, 475Cat.echolamine content, altered, in mouse brain,

locomotor activity and, 1

Cellslamina \T, in cat dorsal horn, effects of pheno-

peridine, 239spermat ogonial, deoxyribonucleic acid synthesis

in bone marrow, dominant lethality and, inrats, effects of hycanthone, 437

Chang, IL, see Liii, C-C., 415Cheney, D. L., see Hanin, I., 68

Cheng, M. C. , see Waud, B. E. , 40

Chlorgyline, effects on types A and B monoamineoxidase of brain, 365

Chiorimipramine, effects on attack elicited byhypothalamic stimulation, relation to brain

biogenic amines, 550

p-Chlorophenylalanine, blockade of 5-hydroxy-trypt ophan facilitat ory act ions on spinal re-

flexes by, 2292-(3-Chloro-o-t.oluidino) nicot-inic acid (see Clo-

nixin)

Chlorphentermine, effects on hypertensive dogs,

308Chiorpromazine

effect on insulin release in vivo and in vitro in rat,423

administration in cocaine-dependent rhesusmonkeys, 8

Clarke, D. E. and Sampath, S. S. : Studies on thefunctional role of intraneuronal monoamine

oxidase, 539

Clonixin [2- (3-chloro-o-toluidino) nicotinic acid],metabolism in man, 152

Cobaltous chlorideeffect on acetaminophen-induced hepatic ne-

crosis, 185, 195

effect on covalent binding in vitro of acetami-nophen in hepatic microsomes, 203

Cocaine-dependent rhesus monkeys , chlorpromazine,

imipramine , morphine and d-amphetamineself-administration in, 8

effect on uptake and accumulation of �1I-6,7-dihydroxytetrahydroisoquinoline by periph-

eral sympathetic nerves, 56

Cohen, G., see Locke, S., 56Commarato, M. A., Winbury, M. M. and Kaplan,

H. IL : Glyceryl t.rinitrate and pentrinitrol

(pentaerythritol trinitrate) : Comparativecardiovascular effect-s in dog, cat and rat by

different routes of administration, 300Conseiller, C. , see Besson, J. M., 239Constantine, J. W. and Purcell, I. M. : Inhibition

of platelet aggregation and of experimentalthrombosis by sudoxicam, 653

Cooke, W. J., Berndt, W. 0. and Mudge, G. H.:Effects of phenobarbital and taurocholate on

biliary excretion of iopanoate and iophenoxate

in the rat, 158

Coronary effects of dopamine in dog, 280

Costa, E., see Hanin, I., 68Covalent binding

in vitro, cytochrome P-450 mediated, role inacetaminophen -induced hepatic necrosis , 203

in vivo, role in acetaminophen-induced hepaticnecrosis, 195

Crayfish, giant axons, effect of spart.eine on nervemembrane potassium conductance in, 47

Creagh, T. H., see de Miranda, P., 588

Cucinell, S. A., see Israili, Z. H., 138Cyclazocine-stimulated behavior in rats , effects

of naloxone, 380

Cyst.eine, pretreatment in mice, effect on aceta-minophen -induced hepat.ic necrosis , 211

Cytochrome P-450-mediated covalent binding invitro, role in acetaminophen-induced hepaticnecrosis, 203

Dapsone, metabolism in man and experimental

animals , formation of N -hydroxy metabolites,138

1)avis, D. C.

see Jollow, I). J. , 195

see Mitchell, J. R.., 185

670 INI)EX Vol. 187

amine in rat, 380

effect of phenylbutazone on distribution, elimi-

see Potter, W. Z., 203Davis, E., see Israili, Z. H., 138

Dayton, P. (;., see Israili, Z. H., 138Deafferentation, effect on acetylcholine turnover

rate in rat salivary glands measured by

steady-state kinetics, 68

Dembiec, 1)., see Locke, S., 56de Miranda, P., Beacham, L. M., III, Creagh, T.

H. and Elion, G. B. : The metabolic fate of themethylnitroimidazole moiety of azathioprine

in the rat, 5882-1)eoxyglucose, assimilation by epithelium and

muscle of guinea-pig seminal vesicle, 430Deoxyribonucleic acid, synthesis in bone marrow,

spermatogonial cells, dominant lethality and,in rats, effects of hycanthone, 437

Deprenyl, effects on types A and B monoamine

oxidase of brain, 365Desipramine, effects on attack elicited by hy-

pothalamic stimulation, relation to brain

biogenic amines, 5506-Desmethylgriseofulvin, as major metabolite of

‘4C-griseofulvin in man, 415Desmethylimipramine, effect on uptake and ac-

cumulation of �H-6, 7-dihydroxytetrahydro-isoquinoline by peripheral sympathetic

nerves, 56

‘4C-Dibenamine, specificity of alpha adrenergicreceptor labeling by, 524

Dicumarol, distribution, elimination and antico-agulant action in rats, effects of phenylbuta-

zone, 176Diethyl maleate, pretreatment in mice, effect on

acetaminophen-induced hepatic necrosis , 211

Diformyl dapsone, metabolism in man and experi-mental animals, 138

Digitalis materials, changes in spinal cord neuralmechanisms associated with, 246

Digitoxigenin, effects on spinal cord neuralmechanisms, 246

Digitoxin, absorption from rat respiratory tract,105

Digoxin, absorption from rat respiratory tract, 105

Dihydroouabain, absorption from rat respiratorytract, 105

‘H-6, 7-Dihydroxytetrahydroisoquinoline, uptake

and accumulation by peripheral sympatheticnerves in vivo, 56

�6a, IOa Dimethyl heptyl tetrahydrocannabinol, in

vitro and in vivo metabolism, 169Dissociation constants, drug-receptor, at mam-

malian neuromuscular junction, effect of

halothane, 40Diuretic response to mercury in dogs, effects of

maleic acid and uranyl on, 620

Dixon, H. L., see Lee, I. P. , 641Dog(s)

antihypertensive effects of sympathomimet.icamines in, 308

beta adrenergic blockade on intramyocardial dis-tribution of coronary blood flow in, 451

cat , rat. and, comparative cardiovascular effects

of glyceryl trinitrat.e and pent.rinitrol by dif-ferent routes of administration in, 300

comparative dependence on adrenergic neural

tone by automaticity in sinus node and atrio-ventricular junction of, 269

coronary and myocardial effects of dopamine in,

280cutaneous vasculature, effect of indomethacin

and eicosa-5,8,11,14-tetraynoic acid (pros-taglandin synthesis inhibitors) on adrenergic

responses in, 315

effects of 6-hydroxydopamine on vagal cardioac-celerator systems in, 99

effects of maleic acid and uranyl on mercurial

diuresis in, 620gracilis muscle, antagonism of vasoconstrictor

response by exercise in, 78heart, antiarrhythmic and electrophysiologic

properties of UM-272 in, 260heart., mechanism of inot.ropic action of bretyl-

ium t.osylat.e on, 121

inhibition of platelet aggregation and experi-

mental thrombosis by sudoxicam in, 653metabolism of � IOa dimethyl heptyl tetrahy-

drocannabinol in, 169myocardium, effect of pentrinitrol, nitroglycerin

and propranolol on small vessel blood content

of, 465reduction of oxyphenbutazone clearance by dl-

propranolol in, 133saliva, ouabain-induced i ncrease in potassium

concentration of, 518skeletal muscle and hindpaw, facilitation of re-

flex vasoconst.riction by prostaglandin F2,, in,495

Dombrosky, J. T., see Mawhinney, M. G., 4301)ominant lethality, spermatogonial cells, de-

oxyribonucieic acid synthesis in bone marrowand, in rats, effects of hycanthone, 437

Dong, E., Jr., see Priola, D. V., 121

L-Dopa, chronically administered, effects in nor-

mal and lesioned cats, 15

Dopamine

brain, elevation during naloxone-precipitated

withdrawal in morphine-dependent. mice and

rats, 558

coronary and myocardial effects in dog, 280

formation in cat brain after L-dopa, 15

in rat brain, effects of cyclazocine, 380

Drug interactions

between aspirin, indomethacin and other drugs

in adjuvant-induced arthritis in rat, 400

between naloxone and cyclazocine or (/-amphet-

1973 INDEX 671

nation and anticoagulant action of dicumarol

in rats, 176

reduction of oxyphenhut azone clearance bydi-propranolol in dog, 133

l)ubinsky, B., Karpowicz, K. and Goldberg, M.E. : Effects of tricyclic antidepressants on at-tack elicited by hypothalamic stimulation:

Relation to brain biogenic amities, 550Duct ligation, effect on acetylcholine turnover

rate in rat salivary glands measured by

steady-state kinetics, 68

Electrophysiologic properties, of UM-272 in canine

heart, 260

Elion, 1;. B., see de Miranda, P., 5885,8,l1,14-Eicosatetraynoic acid

influence OH effects of arachidonic acid and

prostaglandins F�2 and F2a on rat stomachstrip, 501

(prosta.glandin synthesis inhibi t or) , effect onadrenergic responses in dog cutaneous vascit-

lature, 315

lnzymes, detoxifying, role in broniobenzene-in -duced liver necrosis, 218

Ephedrine, effects in hypertensive dogs, 308

Epinephrine, effect on protein synthesis in rat

heart, 482lthacrynic acid, effects on oxidative metabolism

in isolated glomeruli, 352lthanol tolerance in goldfish, 391Exercise, antagonism of vasoconst net or responses

in gracilis muscle of dog by , 78

Fenfluraniine, effects in hypertensive (logs, 308Fishman, J. , Hoffwarg, II . and Ilellnian, L. : 1 )is-

posit ion of naloxone-7 , 8-’lI i n normal andnarcotic-dependent men, 575

Furchgott, H. F., see Kirpekar, S. M., 529

Garlick, 1)., see Burcher, l�., 78(liant axons, crayfish and squid, effect of sparteine

on nerve membrane pot assiuni conduct aitce in,47

(;illette, J. 1�l.see Jollow, I). J. , 195

see Mitchell, J. IL, 185, 211see Potter, W. Z., 203

see Zampaglione, N., 218

(lillilan, H. M., see Lanman, H. (1., 105Gland, salivary, rat, effect of deatlerentation and

duct ligation oii acetylcholine turnover rate

in, measured by steady-state kinetics, 68( ilomerular preparation

isolated, effects of ethacrynic aCid on oxidative

metabolism in, 352pure isolated, from rat- kidneys, effects of eth-

acrynic acid on oxidative metal)olism in, 352

Iure metabolically active, from rat kidneys,isolation, 332

pure metal)olically active, from rat kidneys,

metabolism, 342

( ;hicagonenhancement of cardiac performance in eat with

chronic heart failure, 475

-induced increase in hepatic blood flow and

(/-propranolol clearance in monkey , 581Glucose levels in rats, effect of chlorpromazine,

423

( ;hitat hione, protect ive role in acet aminophen-

induced hepatic necrosis, 211(.;ltttethiniide, effect Ofl metabolism of antipyrine

in man, 612

( lyceryl t rinit rate (see also Nitroglycerin)

pent ri nit ml and , cuniparat ive cardiovasculareffects in dog, cat and rat by different routesof administration, 300

( lycosides, cardiac (see Cardiac glycosides)(.lonier, S., see Zimmerman, B. (1., 315( ;oldherg, i�I. F:. , -see l)ubinsky, B. , 550Goldberg, S. IL, see lloffmeister, F., 8Goldfish, tolerance to ethanol in, 391

Goodrich, J. K., see Somjen, (;. (;., 602

Gracilis muscle (see l\luscle, gracilis)Greizerstein, 11. B. and Smith, C. �I. : l)evelop-

ment and loss of tolerance to ethanol in gold-

fish, 391Green, 1!. 1)., Lefever, (. S., i�heys, E. M. and

Bristow, M. : On the specificity of alpha

adrenergic recel)tor labeling by 14C-Dihen-anline, 524

( ree�i, S. , (‘arr, .1. V. , Sauro, F. lvi. aDd Legator,i\I. S. : l;ffects of hycanthone on spermato-

gonial cells, deoxyribonucleic acid synthesis inhone niarro�v 1111(1 dominant lethality in rats,

437

14(�_( ;ris(�Oft1lvitI , al)sorpt ion , Inetal)olisni and cx-(retion in nian, 415

Gross, (. J. and Wininiry, M. M. : Bela adrenergic

blockade on lot ranivocardial (list ribution of

corotiary blood f1oi�� , 451Guinea pig(s)

brain, metabolisni of ‘4(��lijstttiiii�te in, 34

effec t of halot hane on drug-recept or dissociat ion

constants at neuromuscular junction (If, 40

epithelium tind muscle of seminal vesicle, hexose

1111(1 fl�U�() aCid nssiniilat mit l�’ , 430

heart. , phenylephrine-induced increases of car-

dine (�)ntract ilit y , (ycliC adenosine flU)flO-

phosphate and 1)h�sphorylase a in, 296

influence of tuagnesiuni on calciunt-induced re-

spouses of atrial and vascular muscle of, 86

inhibition of platelet aggregat ion by stidoxicani

in, 653

nietal)olisni of dapsotie in, 138

metabolism of �“ . ‘a” dimethvl heptyl tetrahy-

drocannahinol in, 169

(uzman, � see Villarreal, J. I�., 1

672 INDEX Vol. 187

Haavik, C. 0. and Hardman, H. F. : Evaluation ofthe hypothermic action of tetrahydrocanna-

binols in mice and squirrel monkeys, 568Halot-hane , effect on drug-recept or dissociat ion

constants at mammalian neuromuscular junc-tion, 40

Hamann, K. F., see Besson, J. M., 239

Hamrick, M. , see Zampaglione, N., 218Hanin, I., Cheney, 1.). L., Trabucchi, M., Massa-

relli, H., Wang, C. T. and Costa, E. : Applica-

tion of principles of steady-state kinetics tomeasure acet.ylcholine turnover rate in ratsalivary glands : Effect of deafferentation andduct ligation, 68

Hardman, H. F., see Ilaavik, C. 0. , 568Haseman, J. K., see Somjen, U. (.l. 602heart

blood flow, beta adrenergic blockade on intra-

myocardial distribution of, 451canine, effect of pentrinitrol, nitroglycerin and

propranolol on distribution of blood in, 465dog, antiarrhyt.hmic and electrophysiologic

properties of UM-272 in, 260guinea pig, contractility, increased by phenyl-

ephrine, 296inot.ropic action of bret.ylium tosylate on, 121rat, protein synthesis, effect of sympathomi-

metic drugs, 482heart failure, chronic, in cat, enhancement of car-

diac performance by glucagon, 475Hellman, L., see Fishman, J., 575

Hemodialysis, effect on metabolism of antipyrinein man with chronic renal failure, 612

Herman, S. P., see Somjen, (1. (L, 602hlexose, amino acid and, assiniilation by epit.he-

hum and muscle of guinea-pig seminal vesicle,430

Higgins, C. B., see Vatner, S. F., 280

histamine, mechanism of action on isolated ratuterus, 511

“C-Histamine, metabolism in brain, 34

Ho, I. K., see Iwamoto, E. T., 558Hoffmeister, F. and (oldberg, S. B. : A comparison

of chlorpromaz inc , imipramine , morphineand d-amphetamine self-adm mist ration in

cocaine-dependent- rhesus monkeys, 81Ioltzinan, S. G. and Jewett, H. E. : Stimulation of

behavior in the rat by cyclazocine: Effects ofnaloxone, 380

Homovanillic acid, formation in cat brain after

L-dopa, 15Howe, B. B. and Winbury, M. M.: Fffeet of

pentrinit rol , nitroglycerin and propranolol on

small vessel blood content of the canine myo-cardium, 465

Hycanthone

effects on spermatogonial cells, deoxyribonucleicacid synthesis in bone marrow and dominantlethality in rats, 437

IA-4 and, mutagenic action on yeast, 444Hydroxyamphetami tie , effects in hypertensive

dogs, 3086-Hydroxydopamine

effect on uptake and accumulation of ‘H-6,7-dihydroxytetrahydroisoquinoline by periph-

eral sympathetic nerves, 56effects on vagal cardioaccelerator systems, 99

5-Hydroxyt.ryptamine (see also Serotonin)

possible mediation of 5-hydroxytryptophanfacilitatory actions on spinal reflexes, 229

5-Hydroxytryptophan , facilitat.ory actions on

spinal reflexes, blockade by p-chlorophenyl-alanine, 229

Hypertension , in dogs, effects of sympathomimet.ic

amines, 308Ilypothermic action , of tetrahydrocannabinols in

mice and squirrel monkeys, 568

IA-4, hycanthone and, mutagenic action on yeast,

444Imipramine

chlorpromazine, morphine, d-amphet amine and,

self-administration in cocaine-dependent rue-sus monkeys, 8

effects on attack elicited by hypothalamicstimulation, relation to brain biogenic arnines,

550

Indomet-hacin

influence on effects of arachidonic acid andprostaglandins E2 and F2� on rat stomachstrip, 501

interactions with aspirin and other drugs in ad-

juvant-induced arthritis in rat, 400(prostaglandin synthesis inhibit or) , effect on

adrenergic responses in dog cutaneous vas-culature, 315

Inotropic actionof bretylium tosylate on heart., 121of cardiotonic steroids, antagonism by aldos-

terone, 112

pressor and, of dopamine in dog, parasympatho-1%-tic augmentation, 280

Insulin, release in vito and ii, vitro iii rat, effect ofchlorpromazine, 423

lopanoate, iophenoxate and, hiliary excretion in

rat, effects of phenobarbital and taurocholate,

158lophenoxate, iopanoate and, biliary excretion in

rat., effects of phenoharbital and taurocholate,

158Isomers , of amphet aini ne and met hylamphet a-

mine, self-administration by rats, 27Isometheptane, effects in hypertensive dogs, 308

Isoproterenoleffect on protein synthesis in rat heart, 482inhibition of nerve stimulation-evoked nor-

epinephrine release in cat spleen, 529inotropic effect, antagonism by aldosterone, 112

1973 INDEX 673

Langelier, P., Roberge, A. G., Boucher, R. and

Isoxsuprine, effects in hypertensive dogs, 308

Israili, Z. H., Cucinell, S. A., �‘aught, J., I)avis,E., Lesser, J. M. and Dayton, P. G. : Studies

of the metabolism of dapsone in man and cx-perimental animals : Formation of N-hydroxy

metabolites, 138Iwamoto, E. T., Ho, I. K. and Way, E. L. : Eleva-

tion of brain dopamine during naloxone-precipitated withdrawal in morphine-dc-

pendent mice and rats, 558

J#{228}hnchen, E., Wingard, L. B., Jr. and Levy, G.:Effect of phenylbutazone on the distribution,

elimination and anticoagulant action of di-

cumarol in rats, 176Jakschik, B., see Needleman, P., 324

James, T. N., see Urthaler, F., 269

Jewett, II. E., see Holtzman, S. G., 380Johnson, F�. M., Jr., see Needleman, P., 324Jollow, D. J., Mitchell, J. R., Potter, W. Z., Davis,

D. C., Gillette, J. R. and Brodie, B. B.:Acetaminophen-induced hepat.ic necrosis. II.

Role of covalent binding in vivo, 195

Jollow, D. J.

see Mitchell, J. R., 185, 211

see Potter, W. Z., 203see Zampaglione, N., 218

Kaplan, H. B., see Commarato, M. A., 300

Karpowicz, K., see Dubinsky, B., 550Katchen, B., Buxbaum, S. and Ning, J. : Disposi-

tion of clonixin [2-(3-chloro-o-toluidino)nicotinic acid] in humans, 152

Kauker, 1�I. L. : Micropuncture study of renal ac-tion of prostaglandin A2 (PGA2) in rats, 632

Kidneysrat, isolation of pure metabolically active

glomerular preparation from, 332

rat, metabolism of pure metabolically activeglomerular preparation from, 342

rat, pure isolated glomerular preparation, ef-

fects of ethacrynic acid on oxidative metaho-lism in, 352

Kirpekar, S. M., Furchgott, R. F., Wakade, A. R..

and Prat, J. C. : Inhibition by sympat-homi-metic amines of the release of norepinephrine

evoked by nerve stimulation in the cat spleen,529

Kirsch, M., see Nobel-Allen, N., 475Klein, H., see Somjen, G. G., 602Kniffen, F. J., Schuster, D. P. and Lucchesi, B. II.:

Antiarrhythmic and electrophysiologic prop-

erties of UM-272, dimethyl quaternary pro-pranolol, in the canine heart, 260

Koechel, I). A., see Nigrovic, V., 620Kraft, E., see Zimmerman, B. U., 315Krigman, M. R., see Somjen, G. G., 602

Poirier, l.A. J. : Effects of chronically admin-

istered L-dopa in normal and lesioned cats, 15Lanman, B. C., Gillilati, H. Is-i. and Schanker, L.

S. : Absorption of cardiac glycosides from therat respiratory tract., 105

Lee, I. P. and 1)ixoti, H. L. : Fffects of cadmium Ofl

spermatogenesis st tidied by velocity sedi -mentation cell separation and serial mating,

641

Lefever, (!. S., see Green, B. 1.)., 524

Legator, 1�I. S., see Green, S., 437

Lemberger, L., McMahon, IL 1., Archer, H. A.,

Matsumoto, K. and Rowe, II. : The in vitro

and in vivo metabolism of �6a, 1O�t dimet.hylheptyl t.etrahydrocannabinol (I)MPII), 169

Lesser, J. 1�I., see Israili, Z. H., 138

Levy, Cl., see J#{228}hnchen, E., 176

Lichter, M. , Black, M. and Arias, 1. M. : The

metabolism of ant.ipyrine in patients with

chronic renal failure, 612

Lidocaine, effects on ouabain-induced increase in

dog saliva potassium concentration, 518

Liii, C-C., Magat, J., Chang, H., McGlot.ten, J.

and Symchowit.z , S. : Absorption , metabolismand excretion of ‘4C-griseofulviti in man, 415

Liverblood flow , d-propranolol clearance and , i ii inon-

key, increased by glucagon, 581necrosis , acet arninophen -i nduced , l)rOt.ec Live

role of glutathione, 211necrosis, acetaminophen-induced, role of co-

valent binding in i.ivo, 195necrosis, acetaminophen-induced, role of cyto-

chrome P-450-mediat.ed covalent binding in

vitro, 203necrosis , acetaminophen-induced, role of me-

tabolism, 185

necrosis , bromobenzene-induced , role of de-toxifying enzymes, 218

rat. , biot ransforination of methylnit roimidazole

moiety of azathioprine in, 588

Lloyd, J. W., see Mawhinney, M. (�., 430

Locke, S., Cohen, C;. and Dembiec, D. : Uptake and

accumulat ion (-)f �il -6 , 7-dihydrox\’t et rahydro-isoquinoline by peripheral sympathetic nervesin vivo, 56

Locomotor activity of mice treated with drugs

which alter brain catecholaniine (-ontent, ef-

fects of (i-amphetamine and morphine, 1

Lucchesi, B. R.see Kniffen, F. J. , 260see Nobel-Allen, N., 475

Lupanine, effect on nerve membrane potassiumconductance, 47

Magat-, J., see Liii, C.-C., 415

1’Iagnesium, influence on calcium-induced re-

sponses of atrial and vascular muscle, 86

674 INDEX Vol. 187

Maleic acid, uranyl and, effects on mercurial di-

uresis in dogs, 620Mallov, S. : Effect. of sympathomimetic drugs on

protein synthesis in rat heart, 482

Man

absorption, metabolism and excretion of 14C

griseofulvin in, 415

inhibition of platelet aggregation by sudoxicam

in, 653metabolism of clonixin in, 152

metabolism of dapsone in, 138

normal and narcotic-dependent , disposition of

naloxone-7,8-3H in, 575vith chronic renal failure, metabolism of anti-

pyrine in, 612Massarelli, IL, see Hanin, I., 68

Matsumoto, K., see Lemberger, L., 169Mawhinney, I�I. G., I)ombrosky, J. T., Smith, C.

(.1., Thomas, J. A. and Lloyd, J. W. : Hexose

and amino acid assimilation by the epitheliumand muscle of the guinea-pig seminal vesicle,

430

Mc(.Uot.ten, J., see Liii, C-C. , 415

McMahon, fl. E., see Lemberger, L., 169McNeil!, J. and Verma, S. C. : Phenylephrine-in-

duced increases in cardiac contractility, cyclic

adenosine monophosphate and phosphorylasea, 296

Meadows, 1k-I. (;. , Quah, 5.-K. and von Borstel,

II. C. : Mut.agenic action of hycanthone andIA-4 on yeast, 444

l�Ieezan, E. and Brendel, K. : Effects of ethacrynic

acid on oxidative metabolism in isolated

glomeruli, 352

Meezan, E. , Brendel, K. , Ulreich, J. and Carlson,

E. C. : Properties of a pure metabolically ac-tive glomerular preparation from rat kidneys.

I. Isolation, 332Meezan, E., see Brendel, K., 342Mephentermine, effects in hypertensive dogs, 308

Mercury, diuretic response in dogs, effects ofmaleic acid and uranyl, 620

Metabolism

absorption, excretion and, of 14C-griseofulvin inman, 415

in- vitro and in vivo, of � lOa dimethyl heptyltetrahydrocannabinol , 169

of antipyrine in patients with chronic renal fail-

tire, 612

of clonixin in man, 152of dapsone in man and experiment-al animals,

formation of N-hydroxy metabolites, 138

of ‘4C-histamine in brain, 34of methylnitroimidazole moiety of azathiopri ne

in rat, 588

of naloxone-7,8-�H in normal and narcotic-dependent men, 575

of pure metabolically active glomerular prepara-

tion from rat kidneys, 352

oxidative, in isolated glomeruli, effects of etha-crynic acid, 352

role i n acetaminophen -induced hepat ic necrosis,

185role in bromobenzene-induced liver necrosis, 218

Methamphetamine, effects in hypertensive dogs,

308Metaraminol, effects in hypertensive dogs, 308

Methoxamine

effects in hypertensive dogs, 308inhibition of nerve stimulation-evoked nor-

epinephrine release in cat spleen, 529i\-Iet.hylamphetamine, optical isomers, self-ad-

ministration by rats, 273-i\Iethylcholanthrene

effect on acetaminophen-induced hepat ic necro-sis, 185

effect. Ofl bromobenzene-induced liver necrosis,218

3-O-Methylglticose, assimilation by epithelium

and muscle of guinea-pig seminal vesicle, 430Methylhistamine, effect. on metabolism of hista-

mine in brain, 34Methyl mercury (2o3Hg), uptake in tissues related

to neurotoxic effects, 602

Methylphenidate, effects in hypertensive dogs, 308

Micebrain, metabolism of ‘4C-histamine in, 34

effects of cadmium on spermatogenesis in,studied by velocity sedimentation cell separa-

tion and serial mating, 641heart, uptake and accumulation of �H-6,7-di-

hydroxytetrahydroisoquinoline by, 56

hepatic microsomes, binding of acetaminophen

mediated by cytochrome P-450 in, 203

metabolism of M� lOa dimethyl heptyl tetrahy-drocannabinol in, 169

protective role of glutathione in acetaminophen-induced hepatic necrosis in, 211

role of covalent binding in vivo in acetamino-

phen-induced hepatic necrosis in, 195role of drug metabolism in acetaminophen-in-

duced hepatic necrosis in, 185rats and, morphine-dependent, elevation of

brain dopamine during naloxone-precipitatedwithdrawal in, 558

squirrel monkeys and, hypothermic action oftetrahydrocannabinols in, 568

treated with drugs which alter brain cat.echola-

mine content. , effects of d-amphetamine andmorphine on locomotor activity in, 1

Micropunct.ure study of renal action of prost.a-

glandin A2 in rats, 632Microsomes , hepat ic , binding of acetaminophen

to, mediated by cyt.ochrome P-450, 203Millar, K., see Urthaler, F., 269Millard, R. W., see Vatner, S. F., 280Mitchell, J. II. , Jollow, I). J., Potter, W. Z., l)avis,

11). C., Gillette, J. H. and Brodie, B. B.:

chlorpromazine,

(/-amphet amine

1973 INl)EX 675

Acetaminophen-induced hepat ic necrosis. I.

Role of drug metabolism, 185

Mitchell, J. It, Jollow, 1). J., Potter, W. Z., Gil-lette, J. R. and Brodie, B. B. : Acetaminophen-

induced hepatic necrosis. IV. Protective role

of glutathione, 211Mitchell, J. R.

see Jollow, D. J., 195

see Potter, W. Z., 203see Zampaglione, N., 218

Monkey(s)rhesus, cocaine-dependent.,

imipramine, morphine and

self-administration in, 8rhesus, increase in hepatic blood flow and d-

propranolol clearance by glitcagon in, 581rhesus, metabolism of clonixin in, comparison

with man, 152squirrel, mice and, hypothermic action of tetra-

hydrocannabinols in, 568Monoamine oxidase

intraneuronal , funet ional role , 539type B, in brain, $-phenylet.hylamine as specific

substrate for, 365

Morphine

d-amphetamine and, effects upon locomotor ac-tivity of mice treated with drugs which alterbrain catecholamine content, 1

chlorpromazine , imipramine , d-aniphet amine

and, self-administration in cocaine-dependent

rhesus monkeys, 8-dependent mice and rats, elevation of brain

dopamine during naloxone-precipitated with-drawal in, 558

Mudge, C. H., see Cooke, W. J., 158

Muscleatrial and vascular, influence of magnesium on

calcium-induced responses of, 86

gracilis, dog, antagonism of vasoconstrictor re-

sponses by exercise in, 78skeletal, dog, facilitation of reflex vasoconstric-

tion by prostaglandin Fia hi, 495smooth , vascular, sulfhydryl requi rement for

relaxation of, 324

Mutagenic action of hycanthone and IA-4 on

yeast, 444

Myocardial effects of dopamine in dog, 280

Nalorphine, reversal of phenoperidine effects onlamina V cells in cat dorsal horn, 239

Naloxoneeffects on cyclazocine-stimulated behavior in

rats, 380-precipit ated withdrawal in morphine-depend-

ent mice and rats, elevation of brain dopamine

during, 558Naloxone-7,8-H, disposition in normal and riar-

cotic-dependent men, 575Narahashi, T., see Ohta, M., 47

Narcotic-dependent men , disposit ion of naloxone-

7,8-�H in, 575

Needleman, P., Jakschik, B. and Johnson, E. M.,

Jr. : Sulfhydryl requirement for relaxation of

vascular smooth muscle, 324

Neff, N. H., see Yang, Il.-Y. T., 365Nerve, sympathetic, peripheral, uptake and tic-

cumulation of �H -6 , 7-dihydroxyt.etrahydroiso-

quinoline by, 56

Nerve stimulat ion -evoked norepinephrine release

in cat spleen inhibited by sympathomimetic

amines, 529

Nervous system, rat, uptake of methyl mercury

(203Hg) by, relation to neurotoxic effects, 602

Neuromuscular junction, mammalian, effect ofhalothane OH drug-recept or dissociat ion eon -

stants at, 40

Neurotoxic effects, of methyl mercury (203Hg) re-

lated to uptake in various tissues, 602

Nialamide, used in studies on role of monoamine

oxidase in rat., 539

Nicotine-induced vasoconst riction in dog muscle,

facilitation by prostaglandin Fe,,, 495

Nies, A. S.

see Branch, H. A., 133, 581see Splawinski, J. A. , 501

Nigrovic, V., Koechel, 1). A. and Cafruny, E. J.:The effects of maleic acid and uranyl on mer-

curial diuresis in dogs, 620

Ning, J., see Katchen, B., 152

Nitroglycerin (see also ( ;l�’cer)’l trinitrate)

pentrinitrol, propranolol and, effect on small

vessel blood COII ten t of can i tie myocardium,465

Nobel-Allen, N. , Kirsch, M. and Lucchesi, B. H.:

(Uucagon : Its enhancement of cardiac per-

formance in the cat with chronic heart failure,475

Norepinephrine

brain , levels during naloxone-precipit ated with-drawal in morphine-dependent mice and rats,558

effect on protein synthesis in rat heart, 482

-induced responses in dog gracilis muscle, an-tagonism by exercise, 78

in rat brain, effects of cyclazocine, 380release evoked by nerve stimulation in cat

spleen , inhibi t ion l�’ sympat homimet ic

amines, 529responses of dog paw to, effects of indomethacin

and eicosa-5,8,ll,14-tetraynoic acid (prosta-glandin synthesis inhibitors) , 315

synthesis and levels in rats, role of monoamine

oxidase in, 539

NUSS, (... W., see Van Arman, C. G., 400

Oates, J. A., see Splawinski, J. A., 501

Ohta, M. amid Narahashi, T. : Sparteine interaction

676 INI)EX Vol. 187

Wi th nerve membrane potassium conductance,

47Orci, L., see Ammon, H. P. T., 423

Osterberg, R. E. and Raines, A. : Changes in spinalcord neural mechanisms associated with

digitalis administration, 246

Ouabain

absorption from rat respiratory tract, 105

effects on spinal cord neural mechanisms, 246-induced increase in potassiumn concentration in

dog saliva, 518inotropic effect, antagonism by aldosterone, 112

N-Oxidation metabolites, of dapsone in man and

experimental animals, 138Oxyphenbutazone, clearance in dog, reduction by

(/l-propranolol, 133

Pancreatic islets, rat, effects of chlorpromnazine

423

Pancuroniuni , dissociation (oust ant at niani-malian neuron�uscular j ittict ion , effect ofhalothane, 40

Pardo, E. (., see Vidrio, II., 308

Pentaerythritol trinitrate (see Pentrinitrol)Pent,rinit.rol

glyceryl trinitrate and, comparative eardiovas-cular effects in dog, cat and rat by different

routes of administ rati on , 30()nitroglyceri Ii , propranolol and , effect. on small

vessel blood content of canine myocardium,465

Phenmetrazine, effects in hypertensive (logs, 308Phenobarbital

effect on acetaminol)hen-induced hepatic ne-crosis, 185, 195

effect on bromobenzene-induced liver necrosis,218

taurocholate afl(l, effects on biliary excretion ofiopanoate and iophenoxate in rat, 158

Phenoperidine, effects on lamina V cells in catdorsal horn, 239

Phentermine, effects in hypertensive dogs, 308

Phentolamine, inhibition of nerve stimulation-

evoked norepinephrine release in cat spleen,529

Phenylbutazone, effect on distribution, elimina-

tion and anticoagulant action of dictimarol inrats, 176

$-Phenylethylamine, as specific substrate for typeB monoamine oxidase of brain, 365

Phenylephrine

effect in hypertensive dogs, 308

effect on protein synthesis in rat heart, 482-induced increases imi cardiac contractility, cy-

die adenosine monophosphate and phospho-

rylase a, 296inhibition of nerve stimulation-evoked nor-

epinephrine release in cat spleen, 529

Phosphorylase a, in guinea-pig heart, increased by

phenylephrine, 296Pickens, B., see Yokel, II. A., 27

Piperonyl but-oxide, effect on acetaminophen -i n -duced hepatic necrosis, 185, 195

Plasma decay of iopanoate amid iophenoxate in rat,effects of phenobarbital and taurocholate, 158

Platelet aggregat i on , experimental thrombosisand, inhibition by sudoxicam, 653

Poirier, L. J. , see Langelier, P., 15

Potassiumconcentration in dog saliva, increased by oua-

ham, 518conductance, in nerve membrane, effect of

sparteine, 47Potter, W. Z., 1)avis, D. C., Mitchell, J. II., Jol-

low, D. J., (lillette, J. H. and Brodie, B. B.:Acetaminophen-induced hepatic necrosis. III.

Cytochrome P-450-mediated covalent binding

in vitro, 203Potter, W. Z.

see Jollow, 1). J., 195see Mitchell, J. II., 185, 211

Powell, J. H. and Brody, M. J. : Peripheral facilita-

tion of reflex vas(.)constriction � prostaglan-

din F2�,, 495

Practolol, beta adrenergic blocker, effect on in-

tramvocardial dist ribut ion (.)f coronary blood

flow, 451Prat, J. C. , see Kirpekar, S. M. , 529Priola, 1). V., Spurgeon, H. A., Blauw, A. S., II,

Cannon, W. B. , III and l)ong, E. , Jr. : Mecha-nism of the inotropic action of bretyliumtosvlate on the heart, 121

Priola, 1). V., see Alter, W. A., III, 99Procainamide, effects on ouabain-induced increase

in dog saliva potassium concentration, 518

Propylhexedrine , effects in hypertensive dogs,

308Propranolol

be/a adrenergic blocker, effect on intramyocar-dial distribution of coronary blood flow, 451

effects (iii ouabain-induced increase in dogsaliva potassium concentration, 518

pentrinitrol, nitroglycerin and, effect on small

vessel blood content of canine myocardium,465

quaternary derivative (UM-272), antiarrhyth-

mic and electrophysiologic properties incanine heart-, 260

d-Propranolol, clearance, hepatic blood flow and,

in monkey, increased by glucagon, 581dl-Propranolol , reduction of oxyphenbutazone

clearance in dog by, 133

Prostaglandin(s)

A2, renal action in rats, micropuneture study, 632E2 and F�, arachidonic acid and, effects on

longitudinal stomach strip of rat, 501

1973 INl)EX 677

F2a, facilitation of reflex vasoconstriction by,

495

synthesis inhibitors (indomethacin and eicosa-

5,8,11,14-tetraynoic acid), effect on adrener-

gic responses in dog cutaneous vasculature,315

Protein synthesis in rat heart, effect of sympat.h-ornimetic drugs, 482

Pseudoephedrine, effects in hypertensive dogs, 308Purcell, I. 1�I., see Constantine, J. W., 653

Quah, 5.-K., see Meadows, M. (L, 444Q uinidine, effects on ouabain-induced increase in

dog saliva potassium concentration, 518

Rabbit(s)aortic strips, vascular reaction to vasodilators

in, 324

atria, aldosterone antagonism of positiveinotropic effect of cardiotonic steroids in, 112

influence of magnesium on calcium-induced re-

sponses of atrial and vascular muscle of, 86

inhibition of platelet aggregation by sudoxicam

in, 653

metabolism of �6a,iOa dimethyl heptyl tetra-

hydrocannabinol in, 169

specificity of alpha adrenergic receptor labelingby ‘4C-l)ibenamine in , 524

Raines, A., see Osterberg, R. E., 246

Bat(s)

brain, type B monoamine oxidase in, �3-phenyl-

ethylamine as specific stLbstrate for, 365

dog, cat and, comparative cardiovascular effects

of glyceryl trinitrate amid pentrinitrol by dif-ferent routes of administration in, 300

effect of chlorpromazine on insulin release in

vivo and in vitro in, 423effect of naloxone on cyclazocine-stimulated be-

havior in, 380

effect of phenobarbital and taurocholate on bili-ary excretion of iopanoate and iophenoxat-e

in, 158

effect of hycant.hone on spermatogonial cells,deoxyribonucleic acid synthesis in bone mar-row and dominant lethality in, 437

effect of phenylbut.azone on distribution, elimi-nation and anticoagulant action of dicumarol

in, 176functional role of intraneuronal monoamine

oxidase in, 539heart, protein synthesis, effect of sympatho-

mimetic drugs, 482hepatic microsomes , binding of acet aminophen

mediated by cytochrome P-450 in, 203influence of magnesium on calcium-induced

responses of atrial amid vascular muscle of, 86interactions of aspirin, indomethacin amid other

drugs in adjuvant-induced arthritis in, 400

kidneys, isolation of pure metabolically active

glomerular preparation from, 332kidneys, metabolism of pure metabolically ac-

tive glomerular preparation from, 342kidneys, pure isolated glomerular preparation,

effects of ethacrynic acid on oxidative met aim-

lism in, 352

longitudinal stomach strip, effects of arachi-

donic acid amid prostaglandins E2 and F2,, on,

501metabolic fate of methylnitroimidazole moiety

of azathioprine in, 588metabolism of dapsone in, 138

metabolism of �“ ‘#{176}‘ dimet.hyl heptyl tetra-

hydrocannabinol in, 169

mice and , morphine-dependent , elevat ion ofbrain dopamine during naloxone-precipitated

withdrawal in, 558

renal action of prostaglandin A2 in, micropune-ture study, 632

respiratory tract., absorption of cardiac glyco-

sides from, 105

role of detoxifying emizymes in bromohenzene-induced liver necrosis in, 218

role of drug metabolism in acetaminophen-in-duced hepatic necrosis in, 185

salivary glands, effect of deafferentation andduct ligation on acetyleholine turnover ratein, measured by steady-state kinetics, 69

self-administration of optical isomers of am-phetamine amid methylamphetamine by, 27

tolerant and nontolerant, effects of d- and 1-

amphet amine on fixed-interval and fixed -ratiobehavior in, 372

uptake amid accumulation of �H-6 , 7-dihydroxy-tetrahydroisoquinolimie in, 56

uptake of methyl mercury (203Hg) imi tissues re-

lated to neurotoxic effects in, 602uterus, mechanism of action of histamine on, 511

Reilly, M. A., see Schayer, II. W., 34Renal effects, of prostaglandimm A2 in rats, micro-

puncture study, 632Bemial failure, chronic, in man, metabolism of

antipyrine, 612Reserpine pret reat ment , effect on 5-hydr xyt ryp-

tophan facilit at ory act iomts on spinal reflexes,229

Respiratory tract, rat., absorption of cardiac

glycosides from, 105Risley, E. A., see Vami Armami, C. (.�., 400Boberge, A. (1., see Langelier, P., 15

Boffwarg, H., see Fishman, J., 575Rowe, H. , see Lemberger, L., 169Ryan, M. J., see Zimmerman, B. Ce., 315

Saliva, dog, ouabain-imiduced increase imi potas-siumu comicentratiomi of, 518

Salivary glamid (see Glamid, salivary)

678 INI)EX TToi. 187

Sampath, S. S. , see Clarke, I). E. , 539

Sauro, F. M. , see Greemi, S. , 437Schanker, L. S., -see Lanmami, H. C., 105Schayer, II. W. amid Reilly, M. A. : Metabolismn of

‘IC-histamine in braimi, 34

Schuster, 1). P., see Kniffen, F. J. . 260Self-administratiomi behavior

in cocaine-depemident rhesus monkeys, 8

of optical isomers of amphetamine and methyl-amphetamnimte by rats, 27

Semimial vesicle, epithelium and muscle, guineapig, hexose and amino acid assimilation by,430

Serial mat ing, velocity sedimentation cell separa-tion and, used to study effects of cadmium on

spermat.ogenesis, 641

Serot oni n (see also 5-Hydroxyt rypt amimie)as specific substrate for type A monoamimie oxi-

dase of brain, 365brain, levels dun ng naloxone-precipi t ated with-

drawal in morphine-dependemit mice amid rats,558

in rat brain, effects of cyclazocine, 380

Shamid, I). (.L, see Bramich, H. A., 133, 581Sheys, E. M., see Green, H. 1)., 524

Siegel, I. A. : Increases in potassium concemitratiomiof dog submaxillary saliva during intravenousinfusions of ouabaimi, 518

Sinus nodeatrioventricular j unction amid, dog, depemidence

for automaticity on adremiergic neural tomie,

269

Skeletal muscle (see Muscle, skeletal)SKF 525A, effect on bromobenzene-induced liver

necrosis, 218Smith, C. B. , see Villarreal, J. E., 1

Smith, C. G., see Mawhinney, M. G., 430

Smith, C. M., see Greizerstein, H. B., 391Smooth muscle (see Muscle, smooth)Sodium conductance, in nerve membrane, effect of

sparteine, 47

Somjen, G. G., Herman, S. P., Klein, B., Bru-baker, P. E., Brimier, W. 11., Goodrich, J. K.,

Krigman, M. H. amid Haseman, J. K. : The up-

take of methyl mercury (203Hg) in differenttissues related to its neurotoxic effects, 602

Sparber, S. B. , see Tilson, II. A., 372

Sparteine, effect. on nerve membramie potassiumconductance, 47

Spermatogenesis, effects of cadmium omi, studied

by velocity sedimemitatiomi cell separatiomi amidserial mating, 641

Spinal cordcat, dorsal horn lamimia V cells, effect of pheno-

peridine, 239neural mechanisms, chamiges associated with

digitalis, 246Spine, reflexes, facilitatory actions of 5-by-

droxytryptophan omi, blockade by p-chloro-

phenylalanine, 229Splawinski, J. A. , Nies, A. S. , Sweetman, B. and

Oates, J. A. : The effects of arachidonic acid,

prostaglandin L2 and prostaglandin F2a on

the longitudinal stomach strip of the rat, 501Spleemi , cat , inhibition by sympathomimetic

amines of nerve st imulat iou-evoked miorepi-

nephrine release in, 529

Spurgeomi, H. A.see Alter, W. A., III, 99see Priola, I). V. , 121

Squid, giant axons, effect of sparteine on nerve

membrane potassium conductance imi, 47

steady-state kinetics, use to measure effect. of

deafferemitation and duct ligation on acet.yl-choline turnover rate in rat salivary glamids, 68

Steinke, J. , see Ammomi, H. P. T. , 423

Stomachstrips, rabbit, specificity of alpha adrenergic re-

ceptor labelimig by ‘4C-1)ibenamine in, 524strips, rat, effects of arachidonic acid amid pros-

taglandins E2 and Fia (iti, 501Stripp, B., see Zampagliomie, N. , 218Strophanthidin , inotropic effect , ant agomiism by

aldosterone, 112

Strophanthin, imiotropic effect, antagonism by

aldosterone, 112Sudoxicam, inhibition of platelet aggregation and

experimnental thrombosis by, 653Sulfhydryl requirement. for relaxation of vascular

smooth muscle, 324

Sweetman, B., see Splawimiski, J. A., 501

Symchowitz, S., see Liii, C-C., 415

Sympathetic nerve (see Nerve, sympathetic)

Synipathomimetic amines

antihypertensive effects, 3(i8

effect. on protein symithesis in rat heart, 482

inhibition of norepimiephrimie release evoked by

mierve stimulation imi cat spleen, 529

Taber, C. A. amid Amiderson, E. (�. : Paradoxical

blockade by p-chlorophenylalanimie of 5-

liydroxyt rypt ophan facili t atory actions on

spinal reflexes, 229Taurocholate, phenoharbital amid, effects on bili-

ary excretion of iopanoate amid iophenoxate in

rat, 158Tet raliydrocannabinols , hypot hermic act iomi in

mice and squirrel monkeys, 568Tetrahydrozoline, effects in hypertensive dogs, 308Thomas, J. A. , see Mawhinney, M. G., 430Thrombosis , experiment al , platelet aggregat ion

and, imihibition by sudoxicam, 653Tilsomi, H. A. and Sparber, S. B. : The effects of d-

amid l-amphetamimie on fixed-interval amidfixed-ratio behavior in tolerant and nomi-tolerant rats, 372

1973 INI)EX 679

Tolerance to ethanol imi goldfish, 391Tozzi, S. : The mechanism of actiomi of histamine

on the isolated rat uterus, 511

Trabucchi, M., see Hanin, I., 68

Tricyclic antidepressants, effects on attack

elicited by hypothalamic stimulation relatedto brain biogenic amines, 550

Tubocurarine, dissociation constant at mam-

malian neuromuscular j unct ion , effect ofhalothamme, 40

Turlapaty, P. 1). M. \‘. amid Carrier, 0. , Jr. : Itt-

fluence of magmiesi uni omi calcium-induced

respomises of atrial and vascular muscle, 86

Tyramimie, effects on rat uterus, comparisomi with

histamine, 511

Ulreich, J., see Meezami, E., 332UM-272 (dimethyl quaternary propranolol), anti-

arrhyt hmic amid elect rophysiologic propertiesin camiine heart, 260

Uramiyl, maleic acid amid, effects on mercurial

diuresis imi dogs, 620

Urthaler, F., Millar, K., Burgess, M. J., Abilds-kov, J. A. amid James, T. N. : Comparative de-

pendence on adrenergic neural tone by auto-mnaticitv in the sinus miode and in the atrio-

ventricular junctiomi, 269

Uterus, rat, mechanism of actiomi of histamine omi,511

Vami Arman, C. (l., Nuss, (. W. ami(l Hisley, E. A.:Interactiomis of aspirin , i ndoniethacin andother drugs imi adjuvamit-imiduced arthritis imi

the rat, 400Vasoconstrictor responses

amitagonism by exercise in gracilis muscle of dog,

78reflex, facilitatiomi by prostaglamidimi F.�, 495

Vasodilators, possible reaction with sulfhydryl

groups in vascular smnooth muscle, 324

\rasopressin �i nduced respomises i mi dog gracilis

muscle, amitagonisni by exercise, 78Vatmier, S. F., Millard, H. W. and Higgins, C. B.:

Coronary amid myocardial effects of dopamimie

imi the conscious dog: Parasympatholyticaugniemi t at ion of pressor avid imiot ropic actions,280

Vaught, J., see Israili, Z. II., 138

Velocit y sedinient at ion cell separat ion , serial

matimig and, used to study effects of cadmium

on spermatogenesis, 641

Verma, S. C. , see MeNeill, J. , 296Vidrio, H. and Pardo, E. (. : Antihypertemisive

effects of sympathomimetic amines, 308Villarreal, J. E., Guzman, I%L. and Smith, C. B.:

A comparison of the effects of d-amphetamine

amid morphine upon the locomotor activity ofmuice treated with drugs which alter brain

catecliolanune comitemit , 1Vincenzi, F. F., see Appel, W. C., 112von Borstel, H. C., see Meadows, M. (.!., 444

Wakade, A. IL, see Kirpekar, S. M., 529

Wang, C. T., -see Hamiimi, I., 68Wand, B. l. , Cheng, �I. C. and Wand, D. B.:

Comparison of drug-receptor dissociationconstants at the mammalian neuromuscularjunctiomi in the presence and absemice of halo-thane, 40

Wand, 1). IL, see Wand, B. H., 40

Way, E. L., see Iwamoto, E. T., 558

Weiss, (;. K., see Alter, W. A., III, 99Winhury, M. M.

see Commarato, M. A., 300

see Gross, (.l. J., 451see Howe, B. B., 465

Wingard, 14. B., Jr., see J#{228}hnchen, E., 176

Wyon-Maillard, M. C., -see Bessomi, J. M., 239

Yamig, H.-Y. T. and Neff, N. H. : $-Phemiylet.hyl-amine: A specific substrate for type B mono-amine oxidase of braimi, 365

Yeast, mutagenic act-ion of hycamithomie amid IA-4

on, 444\okel, H. A. and Pickemis, B. : Self-administration

of optical isomers of amphetamimie amid

met hylamphetamimie by rats, 27

Zampagliomie, N., Jollow, 1). J., Mitchell, J. B.,Mtripp, B., Hamrick, M. and Gillette, J. B.:

Hole of detoxifying enzymes in bromobenzene-

imiduced liver necrosis, 218Zimniermami, B. (i., Ryan, M. J., Gomer, S. and

Kraft, E. : Effect of the prostaglandin synthe-

sis imihihitors imidoniethacin amid eicosa-5, 8,1 1 , 14-tet rayiioie iteid on adreiiergic responsesin dog eutamieous vasculature, 315

Zinc , imiteract 0)1) with (adtniumii in spermnatogenic

cells,641

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