neuroservice presentation nov 08 [mode de compatibilité]
TRANSCRIPT
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Electrophysiological tests for the CNS
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� Concept� Positioning
• High Quality Service• Central Nervous System• Functional Electrophysiology
Summary
• Functional Electrophysiology• High Skill Expertise
� Studies• Models• Portfolio• Scope
� Commitments� Benefits� Goal
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NEUROSERVICE provides advanced tests and expertise in Functional Electrophysiology for the CNS :
� In vitro physiologyAcute Brain Slices recording : MEA, Patch-Clamp
Concept
� Acute Brain Slices recording : MEA, Patch-Clamp
� Standardized & Customised tests
[NBQX] in µM0.001 0.01 0.1 1 10 100
Nor
mal
ized
fEP
SP
0.0
0.2
0.4
0.6
0.8
1.0
1.2
n = 5 electrodes (one slice)
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Positioning
FunctionalElectrophysiology
High QualityService
Central Nervous System
High SkillExpertise
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High Quality Service
FlexibilityFlexibility
Expert supportExpert support
Short time Short time
processprocess
Reliability Reliability
of testsof tests
Quality InsuranceQuality Insurance
& Confidentiality& Confidentiality
The best quality ofService to satisfy
your needs
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Central Nervous System
Acute Acute brainbrain
slicesslices
CNS disorders CNS disorders
Single neuron Single neuron TargetsTargets
A wide rangeof recordings
to fit your needs
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Functional Electrophysiology
StandardizedStandardized
protocolsprotocols
CustomizedCustomized
protocolsprotocols
Mid troughoutputMid troughoutput MEA&PatchMEA&Patch
recording recording
The bestElectrophysiologyto empower yourscientific analysis
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High Skill Expertise
ElectrophysiologyElectrophysiology Drug DiscoveryDrug Discovery
NeuroNeuro
PharmacologyPharmacology
NeuroNeuro
PhysiologyPhysiology
A High Expertise to fulfill your needs
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� Molecules effects on neurons and neuronal networks� Targets & mechanisms of action� Interaction of a new molecule with an existing drug� Compound profiling
Studies
� Transgenic mice phenotyping� Consulting
[NBQX] in µM0.001 0.01 0.1 1 10 100
Nor
mal
ized
fEP
SP
0.0
0.2
0.4
0.6
0.8
1.0
1.2
n = 5 electrodes (one slice)
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Models
� Hippocampal slices (glutamat- & GABAergic neurons in DG, CA3, CA1)� Cerebellar slices (Purkinje GABAergic large neurons)� Substantia Nigra (Dopaminergic neurons of pars compacta)compacta)� Cortex slices (glutamat- & GABAergic neurons in 5-6 layers)� Raphe nucleus (Serotoninergic neurons)� Thalamus & cortex� Striatum & brainstem� Spinal Cord
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Portfolio Tests 1/3
Test # Reference compound Target Associated pathologiesP-001 Tetrodotoxin Sodium channel Epilepsy
Pain and Neuropathic PainHuntington’s DiseaseMultiple Sclerosis
P-002 NBQX AMPA/KA receptors StrokeEpilepsyAmyotrophic Lateral Sclerosis
P-003 D-AP5 NMDA receptor Alzheimer’s DiseaseP-003 D-AP5 NMDA receptor Alzheimer’s DiseaseParkinson’s DiseaseHuntington’s DiseaseSchizophrenia
P-004 Bicuculline GABA-A receptors EpilepsyAnxietySleep Disorders
P-005 Ganaxolone GABA-A receptors EpilepsyAnxietySleep disorders
P-006 Gabazin GABA-A receptors EpilepsyAnxietySleep Disorders
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Portfolio Tests 2/3
P-007 DHPG mGluR 1/5 receptors StrokeEpilepsyNeurodegenerationAddictionAnxietyPain Management
P-008 Kainate AMPA/kainate receptors StrokeEpilepsyPainPainCognitive Dysfunctions
P-009 Nifedipine L-Type VDCC StrokeCognitive DysfunctionsEpilepsyDepression
P-010 Physostigmine Acetylcholinesterase Alzheimer’s DiseaseDementiaCognitive DysfunctionAttention Deficits Disorders
P-011 Memantine NMDA receptor Alzheimer’s Diseasenicotinic receptors Parkinson’s Disease
Dementia
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Portfolio Tests 3/3
P-012 R-α-methylhistamine H3 histamine receptor Cognitive DisordersAlzheimer’s DiseaseParkinson’s DiseaseHyperactivity and Attention Deficit DisordersSleep DisordersObesityEpilepsy
P-013 Pyrilamine H1 histamine receptorsRanitidine H2 histamine receptorsRanitidine H2 histamine receptors
P-014 DCG-IV mGluR2 receptor Obsessive-Compulsive DisordersAnxiety/Stress DisordersDrug/Alcool Addiction
P-015 SCH23390 D1 dopamine receptor Cognitive DysfunctionD5 dopamine receptor Parkinson's Disease
P-016 Phenytoin K+ channels EpilepsyCarbamazepine
P-017 Carbamazepine NMDA receptor EpilepsyPhenytoin
P-018 Somatostatin GABA-A receptor Epilepsy
P-019 Diazepam GABA-A receptor Epilepsy
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Scope
Addiction P-007, P-014Alzheimer’s Disease P-003, P-010, P-011, P-012Amyotrophic Lateral Sclerosis P-002Anxiety P-004, P-005, P-006, P-007, P-014Cognitive Disorders P-008, P-009, P-010, P-012, P-015Dementia P-010, P-011Depression P-009Depression P-009Epilepsy P-001, P-002, P-004, P-005, P-006, P-007,
P-008, P-009, P-012, P-016, P-017, P-018, P-019Huntington’s Disease P-003Hyperactivity and Attention Deficit Disorders P-010, P-012Multiple Sclerosis P-001Neurodegeneration P-007Neuropathic Pain P-001Obsessive-Compulsive Disorders P-014Pain P-001, P-007, P-008Parkinson’s Disease P-003, P-011, P-012, P-015Schizophrenia P-003Sleep Disorders P-004, P-005, P-006, P-012Stroke P-002, P-007, P-008, P-009
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� Robust and reproduceable data
� High Quality service
� Short time processes
Commitments
� Short time processes
� Mid-throughoutput
� Expert support
� Confidentiality
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Benefits
� Cost & Time saving
� Risk reducing
� Efficiency in scientific analysis
� Tests capacity
� Flexibility
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Our Goal
To provide you with the best quality services in quality services in
Electrophysiological tests for the CNS to empower your
Science.