Neurological (Emergencies) Treatment TrialsWilliam J. Meurer MD, MSAssistant Professor of Emergency Medicine and NeurologyWilliam G. Barsan Research Forum 27 April 2016

Disclosures• Grant Funding• NIH – NINDS• NIH – NIDCD• AHRQ

• Editorial• Methodology statistics reviews for Academic Emergency Medicine

Journal• Expert Witness• Medical liability consulting

• Financial• No companies or patents• Diversified index funds only

• Sports• Ohio State Fan

Outline• Part 1: Neurological Emergencies Treatment Trials• Pre-history• The launch• The current trials• Why I do this

• Part 2: Clinical Trials Methodology Course• Pre-history• The launch• The current model• Why I do this

• Part 3: DIZTINCT

Part 1: Neurological Emergencies Treatment Trials

A long time ago (1990) in a galaxy (Cincinnati) far, far away…

EPISODE IVA New Hope

Stroke physicians have been stymied for decades without any acute treatments to improve outcomes by reducing the damage from stroke. They have looked to their colleagues, the cardiologists for help, but have met many roadblocks.

John Marler, MD – NINDS

Bill Barsan, MD

NETT – The beginning

NETT – Ongoing Trials

Randomized Controlled Trials

•Not easy•Barriers to entry•Site principal investigator “props”•Not enough being done•Best way to get definitive answers

NINDS Clinical Trials Methodology Course

•Not easy•Barriers to entry•Small clinical trials are the hardest• Junior / new investigators under-resourced•Not enough being done

05/01/2023 R25 NS088248 11

April – July

August 7-11 Ann Arbor

August - October

MarchInstruments / Pre-Review

WebinarsSmall Group Meetings

Travel / Logistics

Didactics / Workshops /Small Groups MANDATORY

Small Groups / Mock Study Sections

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Part 3 - DIZTINCT

www.dizztinct.org

Questions• Thank you• Thank you• Thank you