NATURAL ALLERGY THERAPIES

Dr. Eric Potter

Sanctuary Functional Medicine

EPISODE 5THERAPIES AND

APPROACH

INTRODUCTION

▪ Final episode

▪ Focus on specific therapies

▪ Wrap up with functional approach at SFM

OVERVIEW

▪ Nutraceuticals for Atopic Diseases ▪ Prevention

▪ Acute Therapy

▪ Be aware of side effects and interactions

▪ Role of Pharmaceuticals

▪ Genetics

ATOPIC DISEASES

▪ Hay Fever

▪ Asthma

▪ Eczema and Hives

HAY FEVER

▪ Prevention

▪ Acute therapy

▪ Meds

▪ Procedures

PREVENTION

▪ Local Honey

▪ Quercetin 100-500mg once or twice a day

▪ NAC – N Acetyl Cysteine

▪ Stinging Nettles

▪ Bromelain

▪ Probiotics

▪ Clinical experience – Reishi mushrooms

▪ Omega 3’s ▪ Helms S, Miller A. Natural treatment of chronic rhinosinusitis. Altern Med Rev.

2006;11:196-207

ACUTE THERAPIES

▪ Neti Pot

▪ NAC – mucolytic 200-600mg 2 or 3 times per day

▪ Essential Oils

▪ Vitamin C 500-1000mg 2 or 3 times per day

▪ Methyl folate 1000mcg ▪ Helms S, Miller A. Natural treatment of chronic rhinosinusitis. Altern Med Rev.

2006;11:196-207

SIDE EFFECTS AND INTERACTIONS

▪ Always be aware of drug interactions

▪ And Disease interactions

▪ Check safety in pregnancy

▪ And don’t overdose

▪ WebMD, Consumer Labs, other sites

STINGING NETTLES SIDE EFFECTS

▪ Blood sugar

▪ Diuretic

▪ Blood thinners ▪ http://www.umm.edu/health/medical/altmed/herb/stinging-nettle

QUERCETIN

▪ A Favorite

▪ Clinical benefit in patients

▪ Mast cell stabilizer

▪ Ogasawara H, Middleton E Jr. Effect of selected flavonoids on histamine release (HR) and hydrogen peroxide (H2O2) generation by human leukocytes [abstract]. J Allergy Clin Immunol. 1985;75(suppl 1, pt 2):184.

▪ Middleton E Jr, Drzewiecki G. Flavonoid inhibition of human basophil histamine release stimulated by various agents. Biochem Pharmacol. 1984;33:3333-3338.

▪ Pearce FL, Befus AD, Bienenstock J. Mucosal mast cells. III. Effect of quercetin and other flavonoids on antigen-induced histamine secretion from rat intestinal mast cells. J Allergy Clin Immunol. 1984;73:819-823.

▪ Middleton E Jr, Drzewiecki G, Krishnarao D. Quercetin: an inhibitor of antigen-induced human basophil histamine release. J Immunol. 1981;127:546-550.

▪ Yoshimoto T, Furukawa M, Yamamoto S, et al. Flavonoids: potent inhibitors of arachidonate 5-lipoxygenase. Biochem Biophys Res Commun. 1983;116:612-618.

▪ Middleton E Jr. Effect of flavonoids on basophil histamine release and other secretory systems. Prog Clin Biol Res. 1986;213:493-506.

ASTHMA

▪ Similar to hay fever

▪ Magnesium also

▪ Vitamin D possibly

▪ Shaikh, Mohammed Nadeem et al. “Serum Magnesium and Vitamin D Levels as Indicators of Asthma Severity.” Pulmonary Medicine 2016 (2016): 1643717. PMC. Web. 17 Aug. 2017.

▪ Boonpiyathad, Tadech et al. “Serum Vitamin D Levels and Vitamin D Supplement in Adult Patients with Asthma Exacerbation.” Journal of Allergy 2016 (2016): 4070635. PMC. Web. 17 Aug. 2017.

ECZEMA

▪ Adequate Essential Fatty Acids

▪ Omega 3

▪ Prior therapies

PHARMACEUTICAL ROLE

▪ Breakthrough symptoms

▪ As little as possible

VARIOUS OPTIONS

▪ Sedating antihistamines ▪ Benadryl

▪ Not good for long term therapy

▪ Alzheimer's risk

MORE OPTIONS

▪ Non-sedating antihistamines ▪ Loratadine – weakest

▪ Fexofenadine – medium

▪ Cetirizine and metabolites – strongest ▪ And most sedating

▪ Singular – different mechanism

▪ Nasal Antihistamines

EVEN MORE OPTIONS

▪ Steroids

▪ Inhalers

▪ Oral

▪ Topical

▪ Short term is better

IMPORTANT EMERGENCY OPTIONS

▪ Albuterol type inhalers

▪ Epi Pen can be critical

BONUS SECTION GENETICS

GENETICS

▪ SNPS – some are related

▪ Not always related in different people groups

▪ Still learning what they mean

▪ Doesn’t yet direct therapy ▪ Al-Shobaili, Hani A. et al. “Molecular Genetic of Atopic Dermatitis: An Update.”

International Journal of Health Sciences 10.1 (2016): 96–120. Print.

EXAMPLES

▪ Filaggrin on Chromosome 1q21

▪ And its related genes ▪ SPINK5 and LEKTI

▪ MHC or HLA genes – many

▪ Innate Immune genes

▪ Al-Shobaili, Hani A. et al. “Molecular Genetic of Atopic Dermatitis: An Update.” International Journal of Health Sciences 10.1 (2016): 96–120. Print.

EXAMPLES CONTINUED

▪ Adaptive Immune genes

▪ Drug metabolizing Genes ▪ NAT2 and GST group

▪ Pomegranate and quercetin upregulate NAT2

▪ Other random genes

▪ Al-Shobaili, Hani A. et al. “Molecular Genetic of Atopic Dermatitis: An Update.” International Journal of Health Sciences 10.1 (2016): 96–120. Print.

OTHER POSSIBLE GENE CONNECTIONS

▪ Methylation cycle ▪ MTHFR

▪ DHFR

▪ MTR, MTRR

GENETICS SUMMARY

▪ For now, just risk markers

▪ Not being used to direct care

▪ Future?

▪ When to introduce allergens in diet

▪ What meds to give

▪ Vaccines to use or not

CLOSING REVIEW

CLOSING REVIEW

▪ Lower inflammation

▪ Lower Triggers

▪ Treat the Gut

▪ Integrate natural and conventional therapies

IMPLEMENTING

▪ Easy parts

▪ Lifestyle

▪ Gut restoration

▪ Some nutraceuticals

▪ Allergen avoidance/control

LIFESTYLE

▪ Food changes

▪ Healthy gut changes

▪ Air filters

▪ Water filters

▪ Dust Mite Control

▪ HEPA filters on vacuums

WHY YOU MIGHT NEED MEDICAL GUIDANCE?

▪ Food changes

▪ Healthy gut changes

▪ Air filters

▪ Water filters

▪ Dust Mite Control

▪ HEPA filters on vacuums

TRANSITIONING

▪ Don’t just stop pharmaceuticals without oversight

▪ Add, Improve, Taper

▪ This cannot replace medical care

▪ Just augment it

FINAL WORDSHow would I address in the office?

FUNCTIONAL MEDICINE

▪ History

▪ Living Matrix background

▪ Physical

▪ Testing

▪ Treatment

TESTING

▪ Blood for IgG and IgE

▪ Foods

▪ Environmental

▪ Inflammation markers

▪ Nutritional assessment

PERSONALIZED THERAPY

▪ Apply history, physical, and testing results

▪ Consider how to choose therapies with overlapping good effects

▪ Examples

▪ Quercetin for allergies and sugar and blood pressure

▪ Methyl-folate for anxiety and high histamine

▪ NAC for allergies, detox, oxidative stress

▪ Aim integrative therapies at root cause

CONNECT BY LISTENING AND TEACHING

▪ Restore with the best of both medical worlds ▪ Applied to the whole person

▪ Cultivate by changing families and communities

▪ This is Whole Person for the Glory of God at

▪ Sanctuary Functional Medicine 

NOW … GET OUT THERE AND ENJOY GOD’S GIFT OF LIFE

Sanctuary Functional Medicine

120 Holiday Court

Franklin, TN 37064

615 721 2001

Sanctuaryfunctionalmedicine.org