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  • Nanotechnology

  • Outline

  • 3

    What is nano?

  • 4

    Examples of nanomaterials

  • 5

    Nanoparticles in daily life

  • 6

    Nanoparticles

  • 7

    Products

  • 8

    Products

  • 9

    Companies and nanotechnology

  • 10

    Nanomaterials

  • 11

    Nanoparticle exposure

  • 12

    Nanoparticles for medicine

  • 13

    Medical applications

  • 14

    Evolving landscapes

  • Medical applications

    15

  • Clinical grade products

    16

  • Nanoproducts

    17

  • Immunotherapy

    18

  • Benefits: Gene therapy

    19

  • Benefits: Vaccines

    20

  • Benefits: Lymphatic delivery

    21

  • Benefits: Image guided surgery

    22

  • Toxicity

  • Nanoparticles

  • Terminology

  • Immune system

  • Nanoparticles

  • Structure activity relationship

  • Immune system

  • Bidirectional communication

  • Particle size

  • Protein binding

  • Biodistribution

  • MPS uptake

  • Macrophage polarization

  • Hemolysis

  • Hemolysis

  • Coagulation system

  • Undesirable effects

  • Zeta potential

  • Platelets

  • Endothelial cells

  • Complement activation

  • Fibrous carriers

  • IL-1 induction

  • Cationic liposomes

  • Chemokine induction

  • IFN induction

  • IFN induction

  • API immunotoxicity

  • Platform selection

  • Infusion reactions

  • Infusion reactions

  • 2nd generation liposomes

  • Allergenicity

  • Immunogenicity

  • Anti-PEG antibody

  • Anti-inflammatory properties

  • Immunosuppression

  • Take home message

  • Nanotechnology characterization lab

  • Future directions

  • NCL team

  • NCL immunology team


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