nanotechnology in the delivery of chemicals to a specific location
DESCRIPTION
Nanotechnology in the Delivery of Chemicals to a Specific Location. February 19, 2010 S3: James Kancewick , Michael Koetting , Bradford Lamb. http://www.pharmainfo.net/files/u2882/nanoparticles_0.jpg. Presentation Overview. Overview Pharmaceutical Agricultural. Overview. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/1.jpg)
Nanotechnology in the Delivery of Chemicals to a
Specific Location
February 19, 2010
S3: James Kancewick, Michael Koetting, Bradford Lamb
http://www.pharmainfo.net/files/u2882/nanoparticles_0.jpg
![Page 2: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/2.jpg)
Presentation Overview
1. Overview2. Pharmaceutical3. Agricultural
![Page 3: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/3.jpg)
Overview
• What is nanotechnology?
• Vast range of applications
• Debate over special regulation
![Page 4: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/4.jpg)
Overview
• Medical field – Highly selective approach– Nano– Personalized medicine– Implantable delivery
systems– Easy and Cheap
![Page 5: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/5.jpg)
Overview
• Agriculture– Increase nutrient
absorption– Smart delivery systems
![Page 6: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/6.jpg)
“Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells”
By: Ming, Zhong, et al.
http://www.topnews.in/health/files/cancer-cells1.jpg
![Page 7: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/7.jpg)
Traditional Treatment—Chemotherapy• Cancer caused by genetic mutations that
lead to uninhibited growth• Chemotherapy treats this by either:
– Triggering apoptosis (programmed cell death)– Inhibiting cell division
http://cdin.us/01pics/electron-pics/breast-cancer-cells.jpg
![Page 8: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/8.jpg)
Traditional Treatment—Chemotherapy
• Targets most rapidly dividing cells (usually cancer cells)
• Side effect: other rapidly dividing cells are also affected– Hair– Nails– Intestinal lining
http://www.beasurvivor.com/images/ch12im12.jpg
![Page 9: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/9.jpg)
Nanovehicular Intracellular Targeting
• Uses nanotechnology to deliver anti-cancer drugs to cancerous cells only
• Nanovehicles increase drug specificity by directing drugs to specific locations in the cell (e.g. nucleus) before releasing drug molecule Nanovehicles for drug delivery in
2006 study from Netherlands
http://www.medgadget.com/archives/img/765467intel.jpg
![Page 10: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/10.jpg)
• Most nanovehicles that have been studied are polymer nanoparticles that deliver the toxins doxorubicin (DOX) or paclitaxel (PTX)
• Benefits– Enhanced aqueous solubility– Preferential accumulation at tumor
sites– Reduced side effects– Increased circulation time
• Issues– Low stability– Premature release of drug compound– Few of the studied compounds are
biodegradable, and therefore not well-suited to medical use
http://www.eurekalert.org/multimedia/pub/web/4370_web.jpg
Nanovehicular Intracellular Targeting
![Page 11: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/11.jpg)
Dextran Nanoparticles• Ming, Zhong, et al. developed
dextran nanoparticles by crosslinking dextran and lipoic acid derivatives (Dex-LAs) with catalytic dithiothreitol (DTT)– Highly water soluble– Stable in both dilute and high
salt areas– Biocompatible– Diverse (based on specific
structure)– High drug loading efficiency
(84%)http://www3.interscience.wiley.com/journal/
123189887/abstract
![Page 12: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/12.jpg)
Dextran Nanoparticles• Mechanism
– Nanoparticle self-assembles in water from Dex-LAs
– Binds DOX while in non-reductive environment outside of cells
– Particle/DOX enter cell– Reductive properties of
glutathione (GSH) tripeptides release DOX into nucleus
– GSH is more concentrated in cancerous cells
– Nanoparticles remain in cell and are broken down to safe products dextran and lipoic acid http://www3.interscience.wiley.com/journal/
123189887/abstract
![Page 13: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/13.jpg)
Dextran Nanoparticles• Nanoparticle cross-
linking reduces size of nanoparticles by 10-25%– Easier transport into
cells• Cross-linking was
also found to increase selectivity without adversely affecting drug delivery rate http://www3.interscience.wiley.com/journal/
123189887/abstract
![Page 14: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/14.jpg)
Further Research• Current
nanotechnology based therapy research aids traditional methods– Should find ways to use
nanotechnology to enable better treatment mechanisms
– New drugs that are less destructive and more selective
http://www.fhcrc.org/science/pacr/_private/image_files/student_lab2.jpg
![Page 15: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/15.jpg)
Carbon Nanotubes Are Able ToPenetrate Plant Seed Coat andDramatically Affect Seed Germinationand Plant GrowthMariya Khodakovskaya,†,* Enkeleda Dervishi,†,‡ Meena Mahmood,†,‡ Yang Xu,†,‡ Zhongrui Li,†,‡Fumiya Watanabe,‡ and Alexandru S. Biris†,‡,* Obtained from Nature Online
http://pubs.acs.org/doi/full/10.1021/nn900887m
Control Tomato Seed
No carbon Nanotubes
Seed placed in medium
with carbon nanotubes
![Page 16: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/16.jpg)
The results of CNT on Tomato germination
http://pubs.acs.org/doi/full/10.1021/nn900887m
![Page 17: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/17.jpg)
Results For Tomato seeds
• Significant shorting of germination time• Increased Germination percentage
rates
• Seedlings with developed cotyledons and root system were recognized as fully germinated in this experiment
12 days 20 daysRegular 32% 71%
Treated 74-82% 90%
![Page 18: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/18.jpg)
Results for Tomato Seeds
• Fresh weight of total biomass (leaves, stems and roots) increased 2.5 fold for carbon nanotube treated seeds.
http://www.landrethseeds.com/photos/Tomato/Tomato%20Pictures/German%20Giant.jpg
![Page 19: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/19.jpg)
Could this work for other plants?
• Yes, and no further research is needed.
http://www.flowerpictures.net/adenium/
images/clark_seeds_3months.jpg
http://4.bp.blogspot.com/_UzKDjjtny_o/Sqqn0Em_iDI/AAAAAAAAA2s/8LhE2IqcAzM/s200/Carbon+Nanotubes+Could+Make+Efficient+Solar+C
ells.jpg
![Page 20: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/20.jpg)
Other Areas Of Agriculture Nanotechnology Applications
• Precision Farming– Sensors
• Smart delivery systems– pesticides and
herbicideshttp://www.treehugger.com/20100112-corn-field.jpg
![Page 21: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/21.jpg)
Questions?
![Page 22: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/22.jpg)
Sources• Li, Yu-Ling, Li Zhu, Zhaozhong Liu, Ru Cheng, Fenghua Meng, Jing-
Hao Cui, Shun-Jun Ji, and Zhiyuan Zhong. "Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells." Angewandte Chemie International Edition 48.52 (2009): 9914-918. Wiley Interscience. Wiley, 24 Nov. 2009. Web. 12 Feb. 2010. <http://www3.interscience.wiley.com/journal/123189887/abstract>.
• Khodakovskaya, Mariya, Enkeleda Dervishi, Meena Mahmoud, Yang Xu, Zhongrui Li, Fumiya Watanabe, and Alexandru S. Biris. "Carbon Nanotubes Are Able To Penetrate Plant Seed Coat and Dramatically Affect Seed Germination and Plant Growth." ACS Nano 3.10 (2009): 3221-227. ACS Publications. ACS, 22 Nov. 2009. Web. 12 Feb. 2010. <http://pubs.acs.org/doi/abs/10.1021/nn900887m>.
![Page 23: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/23.jpg)
Group S3 Rebuttal
• On the whole, comments were generally very positive.
• Most negative comments centered on the presentation having too much info on some slides. The topics discussed were very information dense and thus mandated a lot of details be presented; however, we agree that some slides could have been split up into two slides for easier viewing.
![Page 24: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/24.jpg)
Group S1Review of Nanotechnology Use in
Delivery of Chemicals
Group S1
![Page 25: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/25.jpg)
Notes on Presentation
Positive Notes• James was very enthusiastic
and interested in topic• Good use of model• The slide on chemotherapy
was very educational• Michael was very
knowledgeable on background chemistry
Opportunities for Improvement
• Need more background information– Introduction was too short
• Too much text on some slides– Information was good– Needs to be spread out
Group S1
![Page 26: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/26.jpg)
Group S2Review of Nanotechnology Use in
Delivery of ChemicalsChris Heflin
Rachael HoukMike Jones
![Page 27: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/27.jpg)
The Good
• Really liked the use of the fruit to demonstrate the principles
• Lots of pictures that helped explain the topic• Presenters appeared enthusiastic and
knowledgeable
![Page 28: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/28.jpg)
The Not-So-Good
• No mention of further research areas• Failed to address toxicity• Could mention that the paper didn’t talk
about the fruit produced, only the plant during gemination
![Page 29: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/29.jpg)
Scott MarwilDanielle MillerJoshua Moreno
Group S4Review of Nanotechnology Use
in Delivery of Chemicals
![Page 30: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/30.jpg)
Things Done Well Very good job with the illustrations and the
animations especially the model about the nanotubes that was presented
The group did a good job of answering the classes questions in a full and in-depth manner
The group members presenting knew the material and did an good job relaying that knowledge onto the rest of the class
![Page 31: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/31.jpg)
Things That Need Improvement The overall presentation was actually very good
and not a lot of improvements are needed One thing I do think needs changing is that the
conclusion wasn’t that good. The introduction was fantastic but the conclusion left the listener hanging. The questions did help wrap things up though and the group presenting did a good job answering questions.
![Page 32: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/32.jpg)
Group S5Review of Nanotechnology Use in
Delivery of Chemicals
Pradip RijalJason SavatskyTrevor SeidelLaura Young
![Page 33: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/33.jpg)
Presentation Review
• The groups power presentation and visuals were very well done.
• The oral presentation was solid and it was very easy to understand them.
• The group clearly learned from other groups mistakes and was able to not make the same mistakes.
• Some of the slides were a little wordy and detracted from the oral presentation.
![Page 34: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/34.jpg)
Critique by Group S6Michael Trevathan, Daniel Arnold, John Baumhardt, and Michael Tran
Presented by S3
Group S6Review of Nanotechnology Use
in Delivery of Chemicals
![Page 35: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/35.jpg)
Summary It was creative to use straws and fruits to demonstrate how
carbon nano-tubes are used in the agricultural industry
It was excellent to discuss more than one application for a single technology: medicinal applications and agricultural applications.
The use of pictures and graphs were very well done and they were a great supplement to the text.
The negative impact on humans resulting from the use of nanoparticles in agriculture should have been discussed.
![Page 36: Nanotechnology in the Delivery of Chemicals to a Specific Location](https://reader036.vdocuments.site/reader036/viewer/2022062323/568164d3550346895dd702bf/html5/thumbnails/36.jpg)
Summary There was too much information on each Dextran slide to
be able to understand all the information.
It was difficult to read the axes on some of the graphs – they could have been placed on their own slide.
Overall, it was a very insightful and educating presentation.