molecular biology

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Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest AND Unfolding Pathogenesis in Parkinson’s: Breakthrough Suggests Damaged Proteins Travel Between Cells Mateo Zuluaga Gómez Medicine Student UPB Medellín-Colombia

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Page 1: Molecular Biology

Airborne Pathogens Can Induce Mad Cow Disease, New Findings

Suggest AND

Unfolding Pathogenesis in Parkinson’s: Breakthrough Suggests Damaged

Proteins Travel Between Cells 

Mateo Zuluaga GómezMedicine StudentUPBMedellín-Colombia

Page 2: Molecular Biology

FOLDING

Page 3: Molecular Biology

FOLDING

Page 4: Molecular Biology

INTRODUCTION

PRION PROTEIN DNA

REPLICATION

Parkinson Disease affects the Central

Neural System

Page 5: Molecular Biology

Airborne Pathogens Can InduceMad Cow Disease, New Findings

SuggestScience Daily January 14,2011

Page 6: Molecular Biology

Airborne Pathogens Can InduceMad Cow Disease, New Findings

SuggestScience Daily January 14,2011

PRION IS AN INFECTIOUS AGENT

THAT COULD AFFECT THE

HUMAN BODY ON DIFFERENT SITES

PRION COULD REPLICATE HIS DNA

INFORMATION

Page 7: Molecular Biology

Airborne Pathogens Can InduceMad Cow Disease, New Findings

SuggestScience Daily January 14,2011

PRION COULD BE TRANSPORTED BY

THE FOOD INGESTINS AND

SURGICAL ELEMENTS

PRION COULD BE TRANSPORTED BY

THE AIR

NEW INVESTIGATION

Page 8: Molecular Biology

Airborne Pathogens Can InduceMad Cow Disease, New Findings

SuggestScience Daily January 14,2011The investigators made tests with

immunosupresed and

immunocompetents mices to

determine if they would be

vulnerable to the air transmission

prions

Prions can induce mad cow disease

Page 9: Molecular Biology

OBSERVATION

Page 10: Molecular Biology

Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged Proteins Travel Between Cells Science Daily January 26,2011

Page 11: Molecular Biology

Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged

Proteins Travel Between Cells

Science Daily January 26,2011Parkinson is a

degenerative disease that affects the neurons of the

Substancia Nigra. It produces

cognitive alteration , emotional

alteration and loss of the autonomous

functionality

Page 12: Molecular Biology

Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged

Proteins Travel Between Cells

Science Daily January 26,2011

The investigation found a misfolding of

the protein alpha-synuclein

(Implicated in Parkinson´s disease)

Alpha-synuclein

Page 13: Molecular Biology

Unfolding Pathogenesis in Parkinson’s: Break through Suggests Damaged

Proteins Travel Between Cells

Science Daily January 26,2011

Protein Alpha-synuclein

could be transfered from one cell to other one, and also it can

aggregate in cell receptors

Cell Receptor

Page 14: Molecular Biology

OBSERVATION

Page 15: Molecular Biology

MEDICAL UTILITY

The investigations about prions must be

principal topics in health care and also it

may has a real value, to find enigmatic solutions

to problems that this pathogenic agent can develop as the BSE

Page 16: Molecular Biology

MEDICAL UTILITY

The parkinson´s disease is a great topic of world interest that must go stopping due to the

advance in the investigations, it could

have gone away distinguishing information

that has not been reported about the

disease and the manner for helping the patients

who suffer it

Page 17: Molecular Biology

MEDICAL UTILITY

When the science knows the mechanism of the

alpha sinucleina protein the world could work in

different topics, for example the

physiopatology of parkinson and the

treatment indicated to diminish the symptoms

of the patient

Page 18: Molecular Biology

MEDICAL UTILITY

The investigation is an important field in the medicine because it

allows to quantify and to qualify variables and

also it allows other actions for reaching

the medicine

Page 19: Molecular Biology

BIBLIOGRAPHY· 

MARTINEZ S, Lina María. Biología molecular. 3. ed. Medellín: UPB. Fac. de Medicina. 

 

 

· Unfolding Pathogenesis in Parkinson’s: Breakthrough Suggests Damaged Proteins Travel Between Cells. Science Daily. January 26, 2011   Airborne Pathogens Can Induce Mad Cow Disease, New Findings Suggest. Science Daily. January 14, 2011  

Page 20: Molecular Biology

THANK YOU