module 9 lab safety training transport of biological material translate

8/8/2019 Module 9 Lab Safety Training Transport of Biological Material Translate

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2009 Family Health International

Module 9Transport of

Hazardous materials


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Introduction

Clinical and research laboratories often receive and shiphazardous material Biological specimens and microorganisms

Chemicals and reagents

Gas cylinders

Radioactive isotopes

Laboratory waste

Expired chemicals and hazardous waste


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"Dangerous Goods"

for carriageCriteria defined under 9 UN hazard classes

Classify and assign UN number and proper shipping

name

Each has entry in Dangerous Goods List which indicates limitations

packaging

labelling

special provisions


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Hazmat classification ofHazardous material

Hazardousmaterials

CLASS I

Explosives

CLASS II

Gases

CLASS III

Flamablel iquids

CLASS IV

Other flammable

Substance

CLASS V

Oxidizing &

Organic peroxidase

CLASS VI

Toxin & infectious

Substance

CLASS VII

Radioactive

materials

CLASS VIII

Corrosives

CLASS IX

Miscellaneous

dangerous Goods

Division 1.1

Division 1.2

Division 1.3

Division 2.1Flammable

Gas

Division 2.2Non-

flammable

Gas

Division 2.3Toxic

Division 3.1

Flameable liquis

Division 3.2Combustable

liquid

Division 4.1

Flamable solid

Division 4.2

Sp. combustable

\solid

Division 4.3Flameable in

water

Division 5.1

Oxidizers

Division 5.2

Organic

peroxidase

Division 6.1

Toxic substances

Division 6.2

Infectious

substance

Division 1.4

Division 1.5

Division 1.6


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Hazardous material classification

transport symbolsHazardousmaterials

CLASS I

Explosives

CLASS II

Gases

CLASS III

Flamablel iquids

CLASS IV

Other flammable

Substance

CLASS V

Oxidizing &

Organic peroxidase

CLASS VI

Toxin & infectious

Substance

CLASS VII

Radioactive

materials

CLASS VIII

Corrosives

CLASS IX

Miscellaneous

dangerous Goods

Division 1.1

Division 1.2

Division 1.3

Division 2.1Flammable

Gas

Division 2.2Non-

flammable

Gas

Division 2.3Toxic

Division 3.1Flameable liquis

Division 3.2Combustable

liquid

Division 4.1Flamable solid

Division 4.2Sp. combustable

\solid

Division 4.3Flameable in

water

Division 5.1

Oxidizers

Division 5.2Organic

peroxidase

Division 6.1

Toxic substances

Division 1.6

Division 1.2

Division 1.2

Division 1.5


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Individual workers responsibilities

That means

YOU!

Transport of

Biological Materials


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Classification

Packaging

Labelling

Documentation


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International agreements for

transport of dangerous goodsUN Recommendations/ Model Regulations formthe basis for international, regional and nationalregulations

Road ADR

Rail RID

Air ICAO (IATA)

Sea IMDG


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Regulations - Road and Air

transportThe Carriage of Dangerous Goods and Use ofTransportable Pressure Equipment Regulations 2004

cross references to ADR (& RID)

The Genetically Modified Organisms (Contained Use)Regulations 2000

Technical Instructions for the Safe Transport ofDangerous Goods by Air - ICAO

Dangerous Goods Regulations - IATA


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Class 6.2 - Infectious substances

Substances known or reasonably expected to containpathogens

Can cause disease in humans or animals

Certain biological materials meet definition stringent requirements for classification, packaging and labelling

Consider any other hazardous properties

Other biological materials

specific requirements to package safely


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UN numbers andproper shipping names

Exempt human/animal specimen

Genetically modified microorganismUN3245

Clinical waste, Unspecified Bio medical Waste,

regulated medical waste

UN 3291

Infectious substance affecting humans

Genetically modified microorganism

UN 2814A

Infectious substance affecting animals only,

Genetically modified microorganism

UN 2900A

Biological SubstanceUN 3373B

Dry ice, Dangerous goodsUN 1845

Biological materialUN NoCat.


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Category A: an infectious substance which iscarried in a form that, when exposure to it occurs,is capable of causing permanent disability, life-

threatening or fatal disease in otherwise healthyhumans or animalsAssign to UN 2814 or UN 2900

Category B: an infectious substance which does

not meet the criteria for inclusion in Category AAssign to UN 3373


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Following not subject to

regulationsMicro-organisms that are not human or animalpathogens

GMMs that can be handled at CL 1 and are not vectors(and plasmids, naked DNA etc)

Samples from non- human and non-animal sources,that are either unlikely to contain pathogens or may doso at natural level

Exempted materials

Blood, tissues or organs collected for bloodtransfusion, preparation of blood products or fortransplant (all in humans)


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Following not subject to

regulationsDried blood spots

Faecal occult blood screening tests

Not controlled if material not derived from humans oranimals and

possibility, but low probability, contains pathogens, and concentration at natural levels

Examples include foodstuffs, water and environmentalsamples

Send as non-dangerous goods - do not confuse withsending as Exempt specimens


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Refrigerated/cooled materials

Typically use either wet or dry ice

Both may affect packaging

Dry ice on Dangerous Goods List

UN 1845 CARBON DIOXIDE, SOLID Minimal requirements for road transport

Various requirements for air transport

Avoid using liquid nitrogen

contact appropriate authority for advice


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Key point

Category A infectious substances must not be

transported by untrained personnel

Transported in appropriate vehicle with driver trained

and certifiedMust not be carried by passengers as/or in checked

baggage, carry-on baggage or on their person

Must always be transported as separate packages inthe hold and must always be declared


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PackagingAll use triple layer system

For some must use UN type-approved packaging

No limits on quantities per package for road transport

Quantity limits on packages for air transportProcedure and type specified in applicable PackingInstruction


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Triple layer system

Leakproof primary receptacle

wrapped in sufficient absorbent material to absorb theentire contents

Leakproof secondary receptacleOuter packaging (rigid)

Enclose paperwork between secondary and outer


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Triple Packaging

Primary receptacle (labeled,primary water tight, leakproof receptacle containingthe specimen)

Secondary receptacle(durable, water tight, leakproof receptacle containingprimary receptacle)

Outer shipping package(rigid, bearing forms,

permits, etc.)


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Triple Packaging


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Packaging Instruction

UN 2814 or UN 2900 (Category A)

Packing Instruction 620/602 (UN type-approved)

UN 3373 (Category B)

Packing Instruction 650/650

UN 3245 (non-infectious GMMs)

Packing Instruction 904/913

UN 1845 (dry ice)

Packing Instruction ---/904


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Refrigerated/cooled

Ensure packaging maintains integrity when ice meltsor dissipates

Must permit release of gas - ALWAYS place dry iceoutside secondary

Use cold packs or similar for wet ice

If Category A must ensure use UN

type-approved packaging properly

Various options

Eg combination packs, overpacks, thermal control units etc


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Labels

Delivery address

Senders details

Emergency contact details

name and telephone number

And as appropriate

UN number and proper shipping name

Hazard warning label


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Category A

Mark with UN number and proper shipping

name

UN 2814 Or UN 2900

And following hazard warning label


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Category B

Mark with propershipping name

BIOLOGICAL SUBSTANCE,CATEGORY B

And following mark

Note no biohazard

sign or Class number


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GMM (non-infectious)

Mark with UN number and

proper shipping nameUN 3245 GENETICALLY MODIFIED

MICRO-ORGANSIMS

And following hazard

warning label


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Exempt specimens

Mark as appropriate with words

EXEMPT HUMAN SPECIMEN

or

EXEMPT ANIMAL SPECIMEN

No UN number or hazard warning label is

required


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Dry ice transport by air

Mark with UN number, proper

shipping name and net

weight (Kg) of dry ice

UN 1845 DRY ICE ##Kg

And following hazard warning

label


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Packages containing liquids

Must display the following Package

Orientation label on two opposite sides


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Paperwork/documentation

- within packageBetween secondary and outer

Must include Senders details

Delivery details Emergency contact details

Description of the goods

UN number and proper shipping name

And for UN 2814 or UN 2900

Add technical name after proper shipping nameItemised list of contents


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Sending dangerous goods bycourier

Must meet classification, packaging andlabelling requirements

Give full description of goods to courier in

advanceSome couriers will not carry dangerousgoods or impose additional requirements

It is illegal to conceal dangerous goods in

any packaging not showing appropriatelabels


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Sending dangerous goods by post

Must meet both legislative and Post Officerequirements

Various prohibitions and restrictions

Category A prohibited in domestic mail Dry ice prohibited

Maximum amount of infectious substances restrictedto 50g or 50ml

Only certain persons can send by post

Can not send dangerous goods in internationalservice (Exempt specimens allowed)


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Security

Must take measures to minimise theft or misuse

Hand packages over only to properly identified persons

or companies

Packages must always be secure not accessible to general public

Additional considerations for packages containing

Category A materials - high consequence dangerous

goods


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Acknowledgement

The University of Edinburgh Health and

Safety Department

(http://www.safety.ed.ac.uk)Asia-Pacific Biosafety Training Network

(http://apbtn.com)

module 9 lab safety training transport of biological material translate

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