PHARMACOLOGICAL MANAGEMENTBLOOD GLUCOSE-LOWERING MEDICINES

Objectives

Aims of treatment

UKPDS: long-term glucose control

Natural history of type 2 diabetes

Mechanism of action

Biguanides

Biguanides

Sulphonylureas & Meglitinides

Sulphonylureas

Thiazolidinediones

Alpha-glucosidase inhibitors

GLP-1 (Incretin Mimetic Agent)

DPP- 4 inhibitors

Action of GLP-1 & DPP-4 inhibitors

Understanding the names

Activity

The principles of combination therapy

Expected effect of glucose-lowering medicines

Adherence rates

Strategies to help people remember

Activity

Blood glucose targets

Suggested starting medicine (1 of 2)

Suggested starting medicine (2 of 2)

Increasing or adding

Older people with diabetes

Older people with diabetes

Activity

Case study

Summary

References