Miki Lee / OEB 192 – 08.11.12

Mobile genetic elements and adaptive mutation

IS familyhttp://www-is.biotoul.fr/

Effects on bacterial evolution

• An important source of genetic variation– Insertion

– Homologous recombination

Effects on bacterial evolution

— M-evolved— S-evolved— M+S-evolved— M/S-evolved

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MutationLuria–Delbrück experiment Cairns–Foster system

Modified Cairns–Foster system

Kugelberg E. et.al. PNAS 2006;103:17319-17324

Monday (11/17): Physiological basis of fitness

Upcoming talks

Tuesday, 12/16Rich LenskiMichigan State University12:30 pm, 341 Warren Alpert (HMS)