microbivores-the future of nanomedicines

21
MICROBIVORES - NISHANT YADAV SHRI RAM MURTI SMARAK COLLEGE OF ENGG. & TECHNOLOGY PRESENTATION ON

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Page 1: Microbivores-The future of Nanomedicines

MICROBIVORES - NISHANT YADAV

SHRI RAM MURTI SMARAK COLLEGE OF ENGG. & TECHNOLOGY

PRESENTATION ON

Page 2: Microbivores-The future of Nanomedicines

OUTLINE Nanorobots Types of Nanorobots Microbivores Applications Advantages Challenges Conclusion

Page 3: Microbivores-The future of Nanomedicines

NANOROBOTS

Integrated and embedded system Consists of nanosensors, processors

Page 4: Microbivores-The future of Nanomedicines

NANOROBOTS

Picowatts of power required

Transmission Antenna of 200nm size

Sonar communication

Page 5: Microbivores-The future of Nanomedicines

TYPES OF NANOROBOTS

Concept proposed by Dr. Robert A Freitas Basic 3 types- Respirocytes Microbivores Clottocytes

Page 6: Microbivores-The future of Nanomedicines

RESPIROCYTES artificial mechanical red blood cells carry oxygen and carbon dioxide molecules constructed of 18 billion atoms deliever 236 times more oxygen to the body

tissues when compared to natural red blood cells

spherical 1 µm diameter sized

Page 7: Microbivores-The future of Nanomedicines

MICROBIVORE artificial white blood cell or nanorobotic

phagocytes spheroid device 3.4 µm in diameter consist of 610 billion precisely arranged  atoms Traps blood pathogens & breaks them 1000 times faster than white blood cells

Page 8: Microbivores-The future of Nanomedicines

CLOTTOCYTES artificial platelets powered by serum-oxyglucose reduces the clotting time & blood loss performs clotting in approximately 1 sec while the natural time is 4-5

mins

Page 9: Microbivores-The future of Nanomedicines

MICROBIVORE

STRUCTURE Programmed spheroid device  3.4 µm diameter along MAJOR axis and 2 µm

diameter along MINOR axis 610 billion arranged carbon atoms in diamond

structure

Page 10: Microbivores-The future of Nanomedicines

MICROBIVORE

COMPONENTS Four basic components - Binding sites Grapples Morcellation chamber Digestion chamber

Page 11: Microbivores-The future of Nanomedicines

MICROBIVORE

Page 12: Microbivores-The future of Nanomedicines

MICROBIVORE WORKING target bacterium binds to the microbivore

surface via binding sites telescopic robotic grapples rise up from the

surface and attach to the trapped bacterium grapple’s handoff motion can transport the

bacterium from binding site to the ingestion port

Page 13: Microbivores-The future of Nanomedicines

MICROBIVORE the bacterium is internalized into the

morcellation chamber  bacterium is minced into nanoscale pieces remains are pistoned into the digestion

chamber which consists of a pre-programmed set of digestive enzymes

These enzymes are injected and extracted 6 times during a single digestion cycle

Page 14: Microbivores-The future of Nanomedicines

MICROBIVORE Morcellate is progressively reduced into amino

acids, free fatty acid and simple sugars by specifically selected sequence of 40 enzymes

These small molecules are then discharged into the blood stream through the exhaust port

After the destruction of pathogens the microbivores exits the body through the kidneys and are then excreted in urine

Page 15: Microbivores-The future of Nanomedicines

MICROBIVORE Consumes 200 pW power during the operation metabolizes local glucose and oxygen for

power or may be externally supplied with acoustic power

Page 16: Microbivores-The future of Nanomedicines

APPLICATIONS

Drug delivery

Body surveillance

Surgery

Cancer detection and treatment

Page 17: Microbivores-The future of Nanomedicines

APPLICATIONS

 Gene therapy

Diabetes treatment

Page 18: Microbivores-The future of Nanomedicines

ADVANTAGES

Most animal cells are 10,000 to 20,000 nm in diameter so microbivores are easy to inject

Glucose or natural body sugars and oxygen might be a source for propulsion

1000 times faster & 80 times more efficient than natural phagocytes

completely destroy one pathogen in just 30 seconds

Page 19: Microbivores-The future of Nanomedicines

DISADVANTAGES

Change in behaviour at nano level,may not be suitable for body

High cost

Page 20: Microbivores-The future of Nanomedicines

CHALLENGES

Larger nanoparticles may accumulate in vital organs

Nanorobots of larger size will block capillary flow

Page 21: Microbivores-The future of Nanomedicines

CONCLUSION

The concept of microbivores is just a theoritical justification till now

But the recent advancement in the field of nanotechnology gives the hope of the effective use of this technology in medical field

Diseases like AIDs,cancer can be treated permanently at any stage using these technologies

It can be a great replacement for the existing medical technology in terms of fast results and efficiency