methotrexate in ttt of rheumatoid arthritis

Methotrexate in TTT of rheumatoid arthritis

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Methotrexate in TTT of rheumatoid arthritis

Methotrexate:• MOA: Is folic acid antagonist + cytotoxic +

immunosuppressant.• multiple IC enzymes → activation of ˉˉ ˉˉ

PMNLs, T-cells, and macrophages.• Is one of the first line drugs.• Used in >90% of RA cases.• One weekly.• Folic acid 5mg 24 hrs after methotrexate

dose to compensate for folic acid deficiency.

Page 3: Methotrexate in ttt of rheumatoid arthritis

MOA of methotrexate (MTX):

Page 4: Methotrexate in ttt of rheumatoid arthritis

S.E:1. Hepatotoxicity : common (monitor

LFTs),2. Myelosuppression (BMD),3. Teratogenicity.

Review Kimia Medisinal - Methotrexate sebagai obat alternatif dalam pengobatan rheumatoid artritis

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Janssen Research & Development * SynopticClinical Study Report … · 2020. 12. 29. · plus methotrexate (MTX) in subjects with rheumatoid arthritis (RA) who initially responded

Mylan Pharmaceuticals Inc. METHOTREXATE- methotrexate tablet

Arthritis - Home - Truth In Advertisingbeing used to help treat rheumatoid arthritis called methotrexate. The methotrexate was a required medication for him to be able to take another

GLOBALZIRKULATION. T TTT TTT T TTT TTT H HHHH

RASUVO (methotrexate)

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Breast Cancer in Patients of Rheumatoid Arthritis with ...mj-med-u-tokai.com/pdf/420208.pdf · Breast Cancer in Patients of Rheumatoid Arthritis with Methotrexate Therapy Mimicking

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Methotrexate Folic