membranproteiner
DESCRIPTION
Membranproteiner. Kapitel 12. Membranproteiner. Perifera membranproteiner. Integrala membranproteiner. Colicin A. Paradox: Membranprotein Som är lösligt både i vatten och instopppat i membran Alternativ Konformation i lösning jämfört med i membran. Bakterierhodopsin. Bakterierhodopsin. - PowerPoint PPT PresentationTRANSCRIPT
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Membranproteiner
Kapitel 12
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Membranproteiner
Integrala membranproteiner
Perifera membranproteiner
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Colicin A
Paradox: MembranproteinSom är lösligt både i vatten och instopppat i membran
Alternativ Konformation i lösning jämfört med i membran
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Bakterierhodopsin
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Bakterierhodopsin
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Retinal, ljusabsorberande pigment
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RetinalBlå= grundtillstånd
Röd=exciterat tillstånd
Rhodopsin
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Proton förflyttning hos rhodopsin
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Proton förflyttning hos rhodopsin
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Proton förflyttning hos rhodopsin
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Porin
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Trimer av porin
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K+-kanalen
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K+-kanalen
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K+-kanalen
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K+-kanalen
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K+-kanalen
”från sidan” ”uppifrån”
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Fotosyntetiska pigment
Klorofyll
Ubikinon
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Diffraktionsfoto på fotosyntetiska reaktionscentrat
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Fotosyntetiska reaktionscentrat
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Fotosyntetiska pigment
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Schematisk bild över reaktionscentrat
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Light harvesting complex, LH2
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Light harvesting complex, LH2
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Light harvesting complex, LH2
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Light harvesting complex, LH1
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LH1, LH2 och reaktionscentrat
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Energiflöde via LH2 och LH1 till reaktionscentrat
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Hydropathy plot
• Beräkna utgående från ett ”fönster” (19 aa) hydrofobiciteten och plottar mot sekvensen
• Kan förutsäga vilka delar av en transmembranhelix som är inbäddad i membranet
• Kan även användas för cytosoliska proteiner, vilken information får man då?
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Hydropathy plot
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Hur beräknas dessa skalor?
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Några exempel från PDB
• K+-kanalen
• Rhodopsin
• Colicin A
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Signaltransduktion kap 13
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Topologi cH-rasp21
Topologisk brytpunkt
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Bindning av GTP till aktiva ytan
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Inbindning av GTP till transducin
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Komformationsändringar hos transducin
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Transducin
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Komformationsändringar hos transducin
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G protein, Transducin, heterotrimer
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G protein, Transducin, heterotrimer
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G protein, Transducin, -subenheten
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Phosducin, regulator av GTPase aktivitet
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Phosducin, blockerar bindningTill -subenheten
Phosducin bindning till transducin dimer
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Human growth hormone
Four-helix bundle
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Human growth hormone receptor
Immunoglobulinfold
Bindningsyta för HGH
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Bindning av HGH till HGH receptor 1:2 komplex
Osymmetrisk bindning av HGH
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Bindning av Prolactin receptor till HGH 1:1 komplex
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Hormon receptor interaktion
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Hormon receptor interaktion
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Tyrosinkinas familjen
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Src Tyrosinkinas
• Signalprotein som kontrollerar celltillväxt• Signalering sker med hjälp av fosforylering
av tyrosiner• Hundratals olika Tyrosinkinaser som är
närbesläktade, ”Knock-out” ofta ingen effekt
• Onkogen, genen alltid aktiv ger ohämmad celltillväxt, utveckling av cancer
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Src Tyrosinkinas, SH2 domänen
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Src Tyrosinkinas, aktiv och inaktiv form
Från: PDB, ”molecule of the month”
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From: Time Magazine 28 May 2001
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Tyrosinkinas med inbunden Gleevec (Cancermedicin)
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Några exempel från PDB
• Transducin
• G protein trimer
• Inbinding av GTP/GDP kolla konformationsändring
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