medical applications at the university of huddersfield · rob edgecock on behalf of the iiaa,...
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Rob Edgecock on behalf of the IIAA,
University of Huddersfield
Medical Applications at the University of Huddersfield
• Who we are
• Accelerator applications network
• Radioisotope production studies
• Therapy
• Conclusions
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IIAA
Physics Department has existed for 3-4 years: - International Institute of Accelerator Applications - Advanced materials group
IIAA: - 4.5 staff - 2 postdocs - 13 PhD students
Work on: - Medical applications - Thorium and waste transmutation - Meta materials, particularly for RF - MEIS - FETS - Target studies for neutrons and neutrinos - Collimators in HI-LUMI - Neutrons for security screening - Cyclotron studies at PSI - etc
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IIAA
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IIAA
Physics Department has existed for 3-4 years: - International Institute of Accelerator Applications - Advanced materials group
IIAA: - 4.5 staff - 2 postdocs - 13 PhD students
Work on: - Medical applications - Thorium and waste transmutation - Meta materials, particularly for RF - MEIS - FETS - Target studies for neutrons and neutrinos - Collimators in HI-LUMI - Neutrons for security screening - Cyclotron studies at PSI - etc
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EuCARD2 Accelerator Applications Network
EuCARD2: 3rd in series of Accelerator R&D FP6/7 projects Coordinate the Accelerator Applications Network Task leaders:
- Rob Edgecock (Huddersfield) - Marco Cavenago (LNL) - Marco Schippers & David Meer (PSI) - Giulia Bellodi (CERN) - Hywel Owen (Manchester)
Website at: http://eucardapplications.hud.ac.uk/
>53 partners 5 workshops so far, another 5 in preparation
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EuCARD2 Accelerator Applications Network
Modern hadron therapy gantry developments – UMAN & PSI - 16th-17th January 2014 - Cockcroft, UK - https://eventbooking.stfc.ac.uk/news-events/modern-hadron-therapy-gantry-developments-187
Accelerator based neutron production (ABNP2014) - INFN - 14th-15th April 2014 - Legnaro - BNCT, radioisotope production, security, etc - https://agenda.infn.it/conferenceDisplay.py?confId=7214
Compact accelerators for radioisotope production - UMAN - 26th-27th March 2015 - Daresbury, UK - https://eventbooking.stfc.ac.uk/news-events/compact-accelerators-for-isotope-production-254
Compact gantries for charged particle therapy - September 2015 - PSI
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EuCARD2 Accelerator Applications Network
Plan to do an EU version: Updated European focus For policy makers Applications where we can
make a difference Organising committee: Roy Aleksan Oliver Boine-Frankenheim Phil Burrows Angeles Faus-Golfe (Chair) Steve Myers Andrea Pisent Kick-off meeting: 18th-19th June RAEng
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Radioisotope Production
• Well-known 99mTc problems due to (old) reactor production
Moly crisis in 2008/9
Potential shortage in ≥2016 due NRU closure & LEU
Various alternative production methods proposed, including
accelerators
BNMS & STFC Report, December 2014
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Therapeutic Radioisotopes
• All reactor produced
• None in the UK, some in the US
• Supply has been a problem
• Some isotopes need α beams, difficult with cyclotrons: 211At, 67Cu, 47Sc
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FFAG for Radioisotopes
FFAG/strong focussing cyclotron
Injection energy: 75 keV
Extraction: 10 MeV – 102cm 14 MeV – 120cm 28 MeV – 170cm
Isochronous to 0.3%
Very flexible: protons, alphas, variable energy
Huge beam acceptance
Unique features: 20mA internal target
Hud: Roger Barlow, David Bruton, RE STFC: Jim Clarke, Rob Clarke Glasgow: Sally Pimlott PAC: Carol Johnstone
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FFAG for Radioisotopes
FFAG/strong focussing cyclotron
Injection energy: 75 keV
Extraction: 10 MeV – 102cm 14 MeV – 120cm 28 MeV – 170cm
Isochronous to 0.3%
Very flexible: protons, alphas, variable energy
Huge beam acceptance
Unique features: 20mA internal target
Hud: Roger Barlow, David Bruton, RE STFC: Jim Clarke, Rob Clarke Glasgow: Sally Pimlott PAC: Carol Johnstone
Basil Gonsalves working at CERN with Thierry Stora on the MEDICIS target
Target cooling studies: radioisotopes & BNCT
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G4 Simulations
Naomi Ratcliffe
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Therapy
Becky Seviour: Working with Alceli Accelerator Technology Designing a proton & carbon linac for
therapy: - 800MHz RF - 100 Hz operation - 1mm to 10mm FWHM - 0.1mm beam accuracy - 8000 voxel scan in ~1 min - 4% dose homogeneity - <2% dose at 2mm outside target
Aim is a significant cost reduction cf CNAO Huddersfield developing solid state RF Also work with Best Medical
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OpenMed
Modify LEIR for biomedical applications
Accelerate protons up to neon
Vertical beam line
Horizontal beam line
Beam transport lines to two end stations: • Vertical beamline for up to 75 MeV/u • Horizontal beamline for up to 430 MeV/u
Two contributions: Neutron production & shielding
calculations - Roxana Rata
Transport line re-design – Tanjilul Amin
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Clatterbridge
Neutron dose from proton beam – Roxana Rata
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CNAO
Cezarina Chirvase: Studied the motion of the pancreas Using 4D MRI Aim to optimise CNAO treatment using
respiratory gating Moving onto pCT studies in Nice
-5
-3
-1
1
3
5
1 2 3 4 5 6
ph3-
phi [
mm
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Pancreas AP - PRONE 2
abdominalcompressor APmask AP
free breathing AP
-5
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1
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1 2 3 4 5 6
ph3-
phi [
mm
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Pancreas CC - PRONE 2
abdominalcompressor CC
mask CC
free breathing CC
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Conclusions
• IIAA has only existed for a few years
• Small number of staff – but many students!
• Main funding source: grants
• Making important contributions to accelerator applications
• Many in the medical area: - Networking - Radioisotope production - Therapy