measuring benefits and costs of antihypertensive therapy

Current Issues in Pharmacoeconomics 2 - _ Measuring benefits and costs of antihypertensive therapy Would the actuarial, or observational, approach to evaluating the benefits and costs of antihypertensive therapy prove' less fallible' and 'far-sighted', compared with the 'short-sighted' approach based on short-term intervention trials? This question has been raised by Professor Alberto Zanchetti from the University of Milan, Italy. He cited the substantial differences that can occur when actuarial, instead of trial, data are used to calculate the cost per life-year gained as a result of antihypertensive therapy. Using actuarial data, this cost is $US2000-$US5200 for men aged 35-55 years and $US3600-$US7900 for women aged 45-55 years - values which are much lower than those calculated using data based on meta-analyses of clinical trials. In addition, calculations based on actuarial data show that treatment is more cost effective in younger than in older patients, whereas calculations based on trial data show the reverse to be the case. Zanchetti A. Antihypertensive therapy: how to evaluate the benefits. American Journal of Cardiology 79: 3-8. 22 May 1997 PharmacoEconomics & Outcomes News 5 Jul 1997 No. 119 1173-5503/97/0119-0002l$01.00 c Adls International Limited 1997. All rights reserved

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Current Issues in Pharmacoeconomics2 - _

Measuring benefits and costsof antihypertensive therapy

Would the actuarial, or observational, approach toevaluating the benefits and costs of antihypertensivetherapy prove'less fallible' and 'far-sighted', comparedwith the 'short-sighted' approach based on short-termintervention trials? This question has been raised byProfessor Alberto Zanchetti from the University ofMilan, Italy.

He cited the substantial differences that can occurwhen actuarial, instead of trial, data are used to calculatethe cost per life-year gained as a result of antihypertensive therapy. Using actuarial data, this cost is$US2000-$US5200 for men aged 35-55 years and$US3600-$US7900 for women aged 45-55 years- values which are much lower than those calculatedusing data based on meta-analyses of clinical trials.In addition, calculations based on actuarial data showthat treatment is more cost effective in younger thanin older patients, whereas calculations based on trialdata show the reverse to be the case.Zanchetti A. Antihypertensive therapy: how to evaluate the benefits.American Journal of Cardiology 79: 3-8. 22 May 1997 ~'""'.J7

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