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  • MAPK Pathway - docs.abcam.com · Stimulus Activators MAPKKK MAPKK MAPK ERK1 ERK2 JNK1 JNK2 JNK3 ERK5 BMK1 p38 MAPK ... Title: MAPK Pathway.indd Created Date: 10/13/2018 7:41:08 AM
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Stimulus Activators MAPKKK MAPKK MAPK ERK1 ERK2 JNK1 JNK2 JNK3 ERK5 BMK1 p38 MAPK Growth factors, Mitogens Stress, Cytokines, Growth factors Stress, Growth factors, Mitogens Raf Mos Tpl2 MEKK2 MEKK3 Tpl2 MLK3 TAK1 TAO1 DLK MEKK3 ASK1 Tpl2 Ras STE20 Rho TRAF2 TRAF3 Rac Rho Src Ras cdc42 TRAF6 MEK1 MEK2 MEK5 MKK3 MKK4 MKK4 MKK7 MKK6 TAO2 MEKK4 ZAK MEKK1 MLK1/2/3/4 TAO2 MEKK2 ASK1 TAK1 MEKK4 TAO1 DLK ZAK Effect Proliferation Differentiation Inflammation Apoptosis Proliferation Differentiation Metabolism Proliferation Differentiation MAPK pathway To find out more, please visit www.abcam.com Copyright © 2018 Abcam. All rights reserved

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Page 1: MAPK Pathway - docs.abcam.com · Stimulus Activators MAPKKK MAPKK MAPK ERK1 ERK2 JNK1 JNK2 JNK3 ERK5 BMK1 p38 MAPK ... Title: MAPK Pathway.indd Created Date: 10/13/2018 7:41:08 AM

Stimulus

Activators

MAPKKK

MAPKK

MAPK

ERK1 ERK2

JNK1 JNK2

JNK3 ERK5 BMK1p38 MAPK

Growth factors, Mitogens

Stress,Cytokines,

Growth factorsStress,

Growth factors,Mitogens

Raf Mos

Tpl2MEKK2 MEKK3

Tpl2

MLK3 TAK1

TAO1

DLK

MEKK3

ASK1

Tpl2

Ras

STE20 Rho TRAF2

TRAF3

Rac Rho

Src Rascdc42TRAF6

MEK1 MEK2 MEK5

MKK3 MKK4MKK4 MKK7

MKK6

TAO2 MEKK4

ZAK

MEKK1 MLK1/2/3/4 TAO2

MEKK2 ASK1 TAK1

MEKK4 TAO1

DLK ZAK

Fatty acid: albumin

EffectProliferationDifferentiation

InflammationApoptosisProliferationDifferentiationMetabolism

ProliferationDifferentiation

MAPK pathway

To find out more, please visit www.abcam.comCopyright © 2018 Abcam. All rights reserved

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